TWI362937B - Medical compositions for inhibiting brain tumor - Google Patents
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1562937 第96丨24丨67號丨〇〇年3月修正頁1562937 No. 96丨24丨67 Amendment March
—種適用於抑制 九、發明說明： 【發明所屬之技術領域】 本發明係關於一種醫藥組成物，尤指 及治療腦腫瘤醫藥組成物。FIELD OF THE INVENTION The present invention relates to a pharmaceutical composition, and more particularly to a pharmaceutical composition for treating brain tumors.
【先前技術】 腦部腫瘤為一種神經腫瘤，雖然其發生的原因有原發 性及繼發性之不同，但對於病人生活造成之不便或生活品 質之下降則相同。#目前醫藥界可以對於腦腫瘤之治療藥 物並不多，且其對腦腫瘤病人治療之效果並不顯著◊這是 因為腦部組織t有一血腦障壁（BBB，即B1〇〇d以如 10[Prior Art] A brain tumor is a type of neurological tumor. Although the cause of the disease is primary and secondary, the inconvenience to the patient's life or the decline in quality of life is the same. # The current medical community can treat a large number of brain tumors, and its effect on the treatment of brain tumor patients is not significant. This is because brain tissue t has a blood brain barrier (BBB, ie B1〇〇d to 10
Barrier)，其會限制大部分單一化學結構式藥物分子經由」 液直接進入腦内部組織。雖然血腦障壁（B1〇〇d 15 之存在，可以有效地保護腦部組織受到血液中廢物分子土 成之損害，但是同時血腦障壁⑺―也因^ 阻部了可以治療腦部損傷之藥物分子，是以大部分之藥南 分子難以進入腦内部發揮治療之作用。 由於以上所述血腦障壁（B1〇〇d Barder)之藥削 制因素，目前腦腫狀治療係以外科手術之治療為主。奥 而外科手術之成本高，風險性較大，手術後並需要複肺 〜之照護人力’且需要視病人之病情及時間來配合。另一 方面’對於病人而言’其成本高，準備時間常長，且由盾 險而來之心理壓力也相對較高。是以外科手術之治療力 法’雖為目前之腦腫瘤治療之主流，但是對腦腫瘤之治痛 20 r?629J7 ---------------- 而言’並非為最佳之選擇。 由於前述腦腫瘤之治療具有許多明顯之缺點或不便之 處，是以亟需要有一種可以改善，克服或減少以上缺點之 醫藥組成物，以方便醫師或病人進行腦腫瘤之治療。醫界 5冒有提議以中醫藥組成物治療腦腫瘤，以尋求外科手術外 . 之治療方法。然中醫藥組成物以往對於治療腦腫瘤並無記 載，相關之文獻也未提出有有效治療根據之醫藥組成物， _目前以中醫藥組成物治療腦腫瘤多僅止於臆測或嘗試並 無明確可靠之中醫藥組成物可供運用。 10 【發明内容】 15 本發明提供一種抑制或治療腦腫瘤之醫藥組成物，俾 ^透過血腩障壁（Bl〇〇d Brain Barrier)，減緩或抑制腦腫瘤 ’且織之增長，但對正常腦腫瘤細胞之損害微小，甚至使腦 腫瘤縮小或消失，如此而可降低治療成本及風險。 本發明用於抑制或治療腦腫瘤之醫藥組成物，分別為 九組藥材或#材混合物：其—含有膽南星，黃連，黃答， 僵麓，制半夏’防風，沈香，天花，琥抬，冰片，牛黃及 麝香等藥材組合而成之混合物；其二含有曼陀羅花，淮山 :及蜂：等藥材組合而成之混合物;其三含有蒼朮，麻黃， 活丄荊芥，細辛，防風，川烏，草烏，川芎，石斛，全 :二歸：甘草’天麻’何首烏，及雄黃等藥材組合而成 j δ物，其四含有制半夏，天麻，白朮，茯苓，蒼朮， 澤填’陳皮，神曲，麥芽，乾薑，黃柏，天雄，當歸，及 20 Γ362937 畤立月f日修(更)正替換頁 ---- 頁耆；其五含有龍膽草’黃芩，梔子，澤瀉，木通，車前 子’柴胡’當歸，甘草及生地；其六含有人參及附子；其 七含有防風’桂枝，麻黃，.杏仁，芎窮，白芍，人參，甘 草’黃芩’防杞，及附子；其八含有柴胡，黃芩，制半夏， 芍藥，枳實，大黃，生薑，及大棗。Barrier), which limits most of the single chemical structural drug molecules directly into the brain's internal tissues via the fluid. Although the blood-brain barrier (B1〇〇d 15 exists, it can effectively protect the brain tissue from the damage of the waste molecules in the blood, but at the same time, the blood-brain barrier (7) is also a drug that can treat brain damage. Molecules are the most difficult drugs to enter the brain to play a role in the treatment of the drug. Due to the above-mentioned blood brain barrier (B1〇〇d Barder) drug cutting factors, the current brain tumor treatment system is treated with surgery Mainly. The cost of surgery is high and the risk is high. After the operation, it needs the rehabilitation of the lungs~ and it depends on the patient's condition and time. On the other hand, it is costly for the patient. The preparation time is long, and the psychological pressure from the shield insurance is relatively high. It is the treatment of the surgical method' although it is the mainstream of the current brain tumor treatment, but the treatment of brain tumors 20 r? 629J7 ---------------- In terms of 'not the best choice. Because the treatment of brain tumors mentioned above has many obvious shortcomings or inconveniences, it is necessary to have an improvement. Overcome or reduce above The medical composition of the point is to facilitate the treatment of brain tumors by doctors or patients. The medical community 5 has proposed to treat brain tumors with traditional Chinese medicine composition in order to seek treatments other than surgery. However, the composition of traditional Chinese medicine has been treated for the past. There are no records of brain tumors, and the relevant literature does not propose a pharmaceutical composition with effective treatment. _ At present, the treatment of brain tumors with traditional Chinese medicine composition is only limited to speculation or attempt. There is no clear and reliable composition of traditional Chinese medicine. [Explanation] 15 The present invention provides a pharmaceutical composition for inhibiting or treating brain tumors, which can reduce or inhibit brain tumors through the blood-stained barrier (Bl〇〇d Brain Barrier), but grows normally. The damage of brain tumor cells is small, and even the brain tumors are reduced or disappeared, thereby reducing the cost and risk of treatment. The pharmaceutical composition for inhibiting or treating brain tumors of the present invention is respectively a group of nine herbs or a mixture of materials: Contains gallbladder, berberine, yellow, stagnation, system of Pinellia 'wind, agarwood, smallpox, aloe, borneol, bezoar and musk a mixture of mandarins, yam: and bees: a mixture of medicinal herbs; three of which contain Atractylodes, Ephedra, Viburnum, Asarum, Wind, Chuanwu, Caowu, Chuanxiong, Shijie, All: two return: licorice 'Tianma' Polygonum multiflorum, and realgar and other medicinal materials combined to form j δ, the four contain system of Pinellia, Tianma, Atractylodes, Poria, Atractylodes, Ze fill 'Chenpi, Divine Comedy, Malt, Dried Ginger, Cork, Tianxiong, Angelica, and 20 Γ 362937 畤立月f日修(more) is replacing page---- Page 耆; its five contains gentian 'Yellow 芩, 栀子, 泽泻, 木通, 车前子'Chaihu' Angelica, licorice and habitat; its six contains ginseng and aconite; its seven contains wind-proof 'guizhi, ephedra, almond, glutinous, white peony, ginseng, licorice 'Huang Wei' scorpion, and aconite; Eight contains Bupleurum, Astragalus, Pinellia, peony, medlar, rhubarb, ginger, and jujube.
10 15 本發明醫藥組合物中藥材之重量份無限制，較佳為： 其一含有膽南星3至5重量份、黃連3至5重量份、僵蠶3至5 重量份、黃芩3至5重量份、制半夏3至5重量份、防風3至5 重置份、沈香3至5重量份、天花3至5重量份 '琥珀3至5重 董份、冰片0‘5至3重量份、牛黃3至5重量份以及麝香3至5 重里伤’其二含有淮山3至5重量份以及蜂蜜2至4重量份； '、一3有蒼朮3至5重量份、麻黃3至5重量份，羌活3至5重 =份，荊芥3至5重量份，細辛3至5重量份，防風3至5重量 份，川烏3至5重量份，草烏3至5重量份，川琴3至5重量份， 石斛3至5重量份，全蠍3至5重量份，當歸3至5重量份，甘 草3至5重I份，天麻3至5重量份，何首烏3至5重量份，及 雄黃3至5重量份；其四含有制半夏為3至5重量份，天麻為〕 至8重量份，白朮為3至5重量份，茯苓為3至5重量份，蒼朮 二至5重量伤，澤馮為3至5重量份，陳皮為3至5重量份， =曲為3至5重量份’麥芽為3至5重量份，乾墓為3至$重量 份i黃柏為3至5重量份，天雄為3至8重量份，當歸為5至15 重2：伤，及黃耆為3至5重量份；其五含有龍膽草3至5重量 份，黃签3至5重量份，梔子3至5重量份，澤萬3至5重量份， 木通3至5重量份，車前子3至5重量份，柴胡3至5重量份， 20 Γ362937 - -- — 丨。啐湖V日修(.更)正替換頁10 15 The weight of the medicinal material in the pharmaceutical composition of the present invention is not limited, and preferably: one contains 3 to 5 parts by weight of cucumin, 3 to 5 parts by weight of berberine, 3 to 5 parts by weight of silkworm, and 3 to 5 parts by weight of jaundice. Parts, 3 to 5 parts by weight of Pinellia, 3 to 5 parts by wind, 3 to 5 parts by weight of agarwood, 3 to 5 parts by weight of 'Amber 3 to 5 parts by weight, 0'5 to 3 parts by weight of borneol, 3 to 5 parts by weight of bezoar and 3 to 5 parts of musk. '2 contains 5 to 5 parts by weight of Huaishan and 2 to 4 parts by weight of honey; ', 3 has 3 to 5 parts by weight of atractylodes, and 3 to 5 parts by weight of ephedra. 3, 5 parts by weight, 3 parts by weight of schizonepeta, 3 to 5 parts by weight of asarum, 3 to 5 parts by weight of wind, 3 to 5 parts by weight of Chuanwu, 3 to 5 parts by weight of turf, Chuanqin 3 To 5 parts by weight, 3 to 5 parts by weight of sarcophagus, 3 to 5 parts by weight, 3 to 5 parts by weight of Angelica sinensis, 3 to 5 parts by weight of licorice, 3 to 5 parts by weight of Gastrodia elata, 3 to 5 parts by weight of Polygonum multiflorum, and 3 to 5 parts by weight of realgar; 4 to 5 parts by weight of Pinellia, 3 to 5 parts by weight of Tianma, 3 to 5 parts by weight of Atractylodes, 3 to 5 parts by weight of cockroach, and 2 to 5 weights of Atractylodes , Zevon is 3 to 5 parts by weight 3 to 5 parts by weight, = 3 to 5 parts by weight of 'male, 3 to 5 parts by weight, 3 to 5 parts by weight of dry tomb, 3 to 5 parts by weight of cork, and 3 to 8 parts by weight of Tianxiong , Angelica is 5 to 15 weight 2: wound, and jaundice is 3 to 5 parts by weight; five of them contain 3 to 5 parts by weight of gentian, 3 to 5 parts by weight of yellow stalk, and 3 to 5 parts by weight of scorpion, Zewan 3 to 5 parts by weight, Mutong 3 to 5 parts by weight, psyllium 3 to 5 parts by weight, Bupleurum 3 to 5 parts by weight, 20 Γ 362937 - -- 丨.啐湖 V 日修 (.More) is replacing page
10 當歸3至5重量份，甘草3至5重量份及生地3至5重量份；其 六含有人參3至5重量份，及附子3至5重量份；其七含有連 翹3至8重莖份，大黃1至5重量份，芒硝〖至5重量份，甘草ι 至5重量份，梔子1至5重量份，黃芩丨至5重量份，及薄荷1 至5重量份；其八含有防風3至5重量份，桂枝丨至5重量份， 麻黃1至5重量份，杏仁丨至5重量份，芎窮1至5重量份，白 苟1至5重量份，人參！至5重量份’甘草1至5重量份，黃芩） 至5重量份，防杞1至5重量份，及附子i至5重量份；其九含 有柴胡3至9重量份，黃芩3至5重量份，制半夏3至9重量份， 与藥1至5重量份，枳實丨至5重量份，大黃丨至5重量份，生 薑1至5重量份，且大棗}至5重量份。 【實施方式】 本發明醫藥組合物對腦腫瘤之抑制與治療效果之實驗 15 過程步驟如下·· ' (1 )實驗動物 I 採用450公克經植入惡性腦腫瘤細胞株（U87MG ce⑴之 • 裸鼠（nudemiCe)作為實驗動物（Sprague_Dawiy mice)。 (2 )灌食動物 2〇 將藥材製備成水溶液後，依動物體重比例每天早午晚各 灌食動物一次，每次2cc。動物死亡或經預設時間進行斷頭 取出大腦。所有實驗用藥材分九組，製備詳述如下： 實施例一 取藥材膽南星（々/ycre/na/apcm/cM/n B丨ume，3g)，黃 8 連（Cc>/7m ieeia Wallich，3g)，黃答（10 Angelica 3 to 5 parts by weight, licorice 3 to 5 parts by weight and 3 to 5 parts by weight of the raw land; 6 containing ginseng 3 to 5 parts by weight, and 3 to 5 parts by weight of the aconite; 7 containing forsythia 3 to 8 heavy stems 1 to 5 parts by weight of rhubarb, 〖to 5 parts by weight of Glauber's salt, 1 to 5 parts by weight of licorice, 1 to 5 parts by weight of medlar, 1 part by weight of scutellaria, and 1 to 5 parts by weight of menthol; 3 to 5 parts by weight, cassia twig to 5 parts by weight, 1 to 5 parts by weight of ephedra, almond to 5 parts by weight, 1 to 5 parts by weight, 1 to 5 parts by weight of white peony, ginseng! To 5 parts by weight of 'grass 1 to 5 parts by weight, xanthine) to 5 parts by weight, 1 to 5 parts by weight of anti-mite, and i to 5 parts by weight of aconite; 9 to 5 parts by weight of Bupleurum, 3 to 5 parts of Astragalus Parts by weight, 3 to 9 parts by weight of Pinellia, 1 to 5 parts by weight, 枳 to 5 parts by weight, rhubarb to 5 parts by weight, 1 to 5 parts by weight of ginger, and jujube to 5 Parts by weight. [Embodiment] The experiment of the therapeutic effect of the pharmaceutical composition of the present invention on brain tumors is as follows: · (1) Experimental animal I is implanted with a malignant brain tumor cell line of 450 g (U87MG ce(1)• nude mouse (nudemiCe) as a laboratory animal (Sprague_Dawiy mice). (2) After feeding the animal 2, the medicinal material is prepared into an aqueous solution, and the animal is fed once every morning and evening according to the animal body weight ratio, 2 cc each time. The animal is dead or preset. Time to decapitate the brain. All experimental herbs were divided into nine groups, the preparation is detailed as follows: Example 1 Take the medicine bilirubin (々/ycre/na/apcm/cM/n B丨ume, 3g), yellow 8 ( Cc>/7m ieeia Wallich, 3g), yellow answer (
Georgi ’ 3g )，僵蠶（5ow6>；x morz· L·，3g )，制半夏（尸/加///“ ternata Breitenbach > 3g ) ， P方風(Ledebouriella seseloides Wolff，3g)，沈香（y4《Mf/aWaag<3//oc/7aRoxb.，3g)，天 花(Trichosanthes kirilowii Maxim ' 3g )，琥 ίό ( Pinus succinifera Conv. ， 3g)，冰片(Dryobalartops aromatica Gaertner» 3g) » Bos Taurus L. var. domesticus Gmelin » 3g)及靡香（Moic/zwsmc^c/H/erwsLinne，3g)分別進行切 片後，置於水中，以水萃取加熱，並於加熱後過濾藥材之 10 藥渣，取濾液而製得。 實施例二 取藥材曼陀羅weie/ L.)花磨成粉後，加入淮山 粉（/)/〇15£：0/^<3 6(3:0^<35'〇6。&15116，5.4吕），蜂蜜（4.5宮），混合後 按照習知之方法進行藥丸之萃取製備，其中每單一藥丸所 15 含之曼陀羅花生藥含量約為0.04g。 實施例三 取藥材蒼求（/imcea De Candolle，3g )， 麻黃(Ephedra sinica Stapf，3g)，晃活(Notopterygium incisium Ting. J 3g) * Λί ^- ( Schizonepeta tenuifolia Briq. > 20 3g)，系田辛(Asiasarum heterotropoides F. Maekawa var. mandshuricum F. Maekawa ， 3g )，防風（Ledebouriella •sese/o/i/ej· Wolff，3g)，川烏carmic/zae//Debx. Sieb.，3g)，草烏Rich.，3g)，川 Λ4( Ligusticum chuanxiong Hortorum, 3g)» ^ Dendrobium 9Georgi ' 3g ), silkworm (5ow6 >; x morz· L·, 3g ), Pinellia (corpse / plus / / / " ternata Breitenbach > 3g ), P (Fleet of the genus Ledebouriella seseloides Wolff, 3g), agarwood (y4"Mf/aWaag<3//oc/7aRoxb., 3g), smallpox (Trichosanthes kirilowii Maxim ' 3g ), succulent ( Pinus succinifera Conv. , 3g), borneol (Dryobalartops aromatica Gaertner » 3g) » Bos Taurus L Var. domesticus Gmelin » 3g) and musk (Moic/zwsmc^c/H/erwsLinne, 3g) were sliced separately, placed in water, extracted with water and heated, and filtered to remove 10 dregs of the medicinal material. The second embodiment of the medicinal material mandala weei / L.) flower grinding into powder, add yam powder (/) / 〇 15 £: 0 / ^ < 3 6 (3:0 ^ < 35 '〇 6. & 15116, 5.4 Lu), honey (4.5 palaces), after mixing, the pills are extracted according to a conventional method, wherein the content of the mandala peanut medicine contained in each single pill 15 is about 0.04 g. Im求(/imcea De Candolle, 3g ), Ephedra sinica Stapf (3g), swaying (Notopterygium incisium Ting. J 3g) * Λί ^- (Schizonepeta tenuifolia Briq. > 20 3g), Asiasarum heterotropoides F. Maekawa var. mandshuricum F. Maekawa (3g), windproof (Ledebouriella • sese/o/i/ej· Wolff, 3g), Chuanwu carmic/zae//Debx. Sieb., 3g), Caowu Rich., 3g), Ligusticum chuanxiong Hortorum (3g)» ^ Dendrobium 9
-1362937 woM/e Lindley ’ 3g) ’ 全缴（Karsch，3g)， 當歸（Diels，3g )，甘草（G(yc少rr/nza wna/e”·^ Fischer et DC，3g)，天麻(Gtmro山<3 e/ααία Blume，3g) ’ 何首烏（户mw/i(/7orwm Thunberg， -5 3g)，及雄黃（Realgar，3g )分別進行切片後，置於水中， - 以水萃取加熱，並於加熱後過濾藥材之藥渣，取濾液而製 得。-1362937 woM/e Lindley ' 3g) 'Full payment (Karsch, 3g), Angelica (Diels, 3g), licorice (G (yc less rr/nza wna/e"·^ Fischer et DC, 3g), Gastrodia (Gtmro Mountain <3 e/ααία Blume, 3g) 'Heshouwu (mw/i (/7orwm Thunberg, -5 3g), and realgar (Realgar, 3g) are sliced separately, placed in water, - heated by water extraction, And after heating, the drug residue of the medicinal material is filtered, and the filtrate is obtained.
10 1510 15
20 實施例四 取藥材制半夏ierrtaio Breitenbach，3g)， 天麻（e/ααία Blume，5g )，白求（jiraciy/oi/e·? σναία De Canndolle，3g )，获茶（Pori'a cocos (SCHW.) WOLF.， 3g)，蒼求（diracO^/odes/awceaDeCandolle，3g)，澤潔 (Alisma plantago - aquatica L. var. orientale SAM. * 3g)， 陳皮（CVirws reiz'cw/αία Blanco，3g )，神曲（Massa Medicata Fermentata，3g) ’參芽（_ Hordeum vuZgare L.，3g)，乾 M： ( Zingiber officinale Roscoe 5 3g)，董构 Q Phellodendron amurense RUPR. > 3g)，天雄(dcowz’iww carmic/zae//Debx. Sieb. ’ 5g ) ’ 當歸（h⑽Diels，3g )，及黃耆 Bun.ge，lOg)分另'J 進行切片後’ 置於水中，以水萃取加熱，並於加熱後過濾藥材之藥渣， 取濾液而製得。 實施例五 取藥材龍膽草（1.5g)，黃答（20 Example 4: Take the medicinal material Pinellia ierrtaio Breitenbach, 3g), Gastrodia elata (e/ααία Blume, 5g), Baiqiu (jiraciy/oi/e·? σναία De Canndolle, 3g), get tea (Pori'a cocos ( SCHW.) WOLF., 3g), sacred (diracO^/odes/awceaDeCandolle, 3g), Alseria plantago - aquatica L. var. orientale SAM. * 3g, CVirws reiz'cw/αία Blanco, 3g), Divine Comedy (Massa Medicata Fermentata, 3g) 'Parade (_ Hordeum vuZgare L., 3g), Dry M: (Zingiber officinale Roscoe 5 3g), Dong Q (Q Phellodendron amurense RUPR. > 3g), Tianxiong ( Dcowz'iww carmic/zae//Debx. Sieb. ' 5g ) ' Angelica (h(10)Diels, 3g), and Astragalus Bun.ge, lOg) are separated into 'J after slicing' and placed in water, extracted with water and heated, and After heating, the drug residue of the medicinal material is filtered, and the filtrate is obtained. Example 5 Take the medicinal material gentian (1.5g), yellow answer (
Georgi ’ 3g)，檢子（Ellis ’ 1.5g)， 10 Μ册37 οGeorgi ’ 3g), proton (Ellis ’ 1.5g), 10 37 37 ο
澤漠(Alisma plantago - aquatica L. var. orientale SAM. * 3g )，木通(/ioc分mot/u/iMr/ewjh (Kom.) Nakai ’ 5g ) ’ 車前子（户/训化和 Linne ’ 3g)，楽胡（Bupleurum /a/c<3iww Linne，3g)，當歸（Diels，5g)， 甘草（G/_ycyrrA/_za wra/ew·?/·? Fischer et DC，1.5g)及生地 (Rehmannia glutinosa Libosch. f. hueichingensis (Chao et Schih)Hsiao，5g)分別進行切片後’置於水中，以水萃取 加熱，並於加熱後過濾藥材之藥渣，取濾液而製得。 實施例六 取藥材人參（尸⑽似C· A. MEYER ’ 3g ) ’附 子（Jcom’iw/w Debx. Sieb. ’ 3g)分別進行切片 後，置於水中，以水萃取加熱，並於加熱後過濾藥材之藥 渣，取濾液而製得。 實施例七 取藥材連魅(尸⑼m (Thunb.) Vahl ’ 4g ) ’ 大黃（及/^wm pa/waiww Linne，2g )，芒硝（Na2S〇4 ’ 2g ) ’ 甘草（Fischer et DC ’ 2g)，檐子 (Gardem’a Ellis，lg) ’ 黃答（ baicaiensis Georgi，l g)，薄荷 C Meriiha haP!〇c’yx BR1Q. ’ 1 g )分別進行切片後，置於水中，以水萃取加熱’並於加 熱後過濾藥材之藥渣，取濾液而製得。 實施例八 取藥材防風（Lede6owrz.e"i2 Wolff，3g)， 桂枝(Presl. ’ 2g ) ’ 麻貫（五 20 1362937Alisma plantago - aquatica L. var. orientale SAM. * 3g ), Mutong (/ioc points mot/u/iMr/ewjh (Kom.) Nakai ' 5g ) 'Plantago (household/training and Linne) '3g), Bupleurum /a/c<3iww Linne, 3g), Angelica (Diels, 5g), licorice (G/_ycyrrA/_za wra/ew·?/·? Fischer et DC, 1.5g) and habitat (Rehmannia glutinosa Libosch. f. hueichingensis (Chao et Schih) Hsiao, 5g) was separately sliced and placed in water, extracted with water and heated, and filtered to remove the dregs of the medicinal material after heating, and the filtrate was obtained. Example 6 Take the medicinal material ginseng (corpse (10) like C·A. MEYER ' 3g ) 'Aconite (Jcom'iw/w Debx. Sieb. ' 3g) was sliced separately, placed in water, heated by water extraction, and heated After the drug residue of the medicinal material is filtered, the filtrate is obtained. Example 7 Take the medicinal material Lianmei (Thunb. Vahl '4g ) 'Rhubarium (and /^wm pa/waiww Linne, 2g), Glauber's salt (Na2S〇4 ' 2g ) ' Licorice (Fischer et DC ' 2g ), dem子 (Gardem'a Ellis, lg) 'Huang (baicaiensis Georgi, lg), mint C Meriiha haP! 〇c'yx BR1Q. ' 1 g ) separately sliced, placed in water, extracted with water 'And after heating, the drug residue of the medicinal material is filtered, and the filtrate is obtained. Example 8 Take the medicinal material against wind (Lede6owrz.e"i2 Wolff, 3g), cassia twig (Presl. '2g ) ‘ 麻贯(五 20 1362937
10 1510 15
20 =^月(/：日修(更)正替20 = ^ month (/: day repair (more) positive
Stapf ’ 2g )，杏仁（arwem·加“ L. var. ansu Maxim.， 2g ) ’芎窮(Ligusticum chuanxiong Η〇η〇ι:\ιτη ’ 2g) ’白芍 (Paeonia lactiflora Pall.2g) ’ Λ #- ( Panax ginseng C. A. MEYER 5 2g) » # ^ ( Glycyrrhiza uralensis Fischer et DC > 2g ) ’黃答(Scutellaria baicalensis Georgi ， 2g )，防； (Stephania tetrandra S. Moore，2g)，附子(Aconitum carw/c/zae" Debx. Sieb.，1 g )分別進行切片後，置於水中， 以水萃取加熱，並於加熱後過;慮藥材之藥渣，取遽液而製 實施例九 取藥材柴胡（5w/?/ewrwm/a/c<3iww Linne，6g)，黃答 (Scutellaria baicalensis Georgi ’ 3g)，制半夏（尸/似///^ ierwaia Breitenbach，4g)，芍藥（尸aeowz’a Pall.， 3g)，好、f ( Citrus aurantium h.，2g)，KK Rheum palmatum Linne，1.5g)，生薑 i Zingiber officinale Koscoe，2g) » 大棗（Mill.，3g )分別進行切片後，置於水 中，以水萃取加熱，並於加熱後過濾藥材之藥渣，取濾液 而製得。 (3 )動物分組 於實驗中使用動物10組，每組3隻，其中一組為對照組， 灌食食鹽水；另外9組為實驗組，分別灌食上述九種醫藥組 合物。 於實驗中，對照組之裸鼠於第四週全部死亡，存活率 為0。而於其他實驗組於不同時間存活率之結果詳列於下： 12 Γ362937 I。年翎 < 日m更)正替換頁Stapf ' 2g ), almond (arwem·plus "L. var. ansu Maxim., 2g ) 'Ligusticum chuanxiong Η〇η〇ι:\ιτη ' 2g) '白芍(Paeonia lactiflora Pall.2g) ' Λ #- ( Panax ginseng CA MEYER 5 2g) » # ^ ( Glycyrrhiza uralensis Fischer et DC > 2g ) 'Scutellaria baicalensis Georgi (2g), Prevention; (Stephania tetrandra S. Moore, 2g), Aconite (Aconitum carw /c/zae" Debx. Sieb., 1 g) separately sliced, placed in water, extracted with water and heated, and heated after heating; taking the medicinal material dregs, taking sputum to make the ninth medicinal material Hu (5w/?/ewrwm/a/c<3iww Linne, 6g), yellow answer (Scutellaria baicalensis Georgi '3g), Pinellia (corpse/like///^ ierwaia Breitenbach, 4g), peony (corporate aeowz' a Pall., 3g), good, f ( Citrus aurantium h., 2g), KK Rheum palmatum Linne, 1.5g), ginger i Zingiber officinale Koscoe, 2g) » Jujube (Mill., 3g) , placed in water, extracted with water, and heated to filter the dregs of the medicinal material, and the filtrate is obtained. (3) Animals were grouped into 10 groups of animals in the experiment, 3 in each group, one group was the control group, and the saline was fed; the other 9 groups were the experimental group, and the above nine pharmaceutical compositions were respectively administered. The nude mice in the control group all died in the fourth week, and the survival rate was 0. The results of the survival rates in other experimental groups at different times are listed below: 12 Γ362937 I. Year 翎<日 m更) replacement page
第6週 第7週 第8週 第9週 第10週 第11週 第12週 實施例 100% 100% 100% 100% 100% 100% 100% 實施例 100% 100% 100% 100% 100% 66.7% 66.7% 實施例 100% 100% 100% 100% 66.7% 66.7% 33.3% 實施例 四 100% 100% 100% 66.7% 66.7% 66.7% 33.3% 實施例 五 100% 100% 66.7% 66.7% 66.7% 66.7% 33.3% 實施例 六 100% 100% 66.7% 33.3% 33.3% 33.3% 33.3% 實施例 七 66.7% 66.7% 33.3% 33.3% 33.3% 33.3% 33.3% 實施例 八 100% 100% 33.3% 33.3% 0% 0% 0% 實施例 九 100% 100% 100% 100% 100% 100% 100% 在實驗中，以九種醫藥組合物灌食裸鼠。實驗結果發 現實施例一至九等九種醫藥組合物對於所測試之腦腫瘤損 傷有保護作用（即腦腫瘤範圍有縮小），且裸鼠之四週後 存活率也提升，亦即對於腦腫瘤抑制預防或治療效果。 - 上述九種醫藥組合物，除實施例皆為複方。本發明之 . 醫藥組成物對治療抑制腦腫瘤都為有效的醫藥組合物。 上述實施例僅係為了方便說明而舉例而已，本發明所 主張之權利範圍自應以申請專利範圍所述為準，而非僅限 10 於上述實施例。 【圖式簡單說明】 13 1362937 無 【主要元件符號說明】 益 «»»»Week 6 Week 8 Week 8 Week 9 Week 10 Week 11 Week 12 Example 100% 100% 100% 100% 100% 100% 100% Example 100% 100% 100% 100% 100% 66.7 % 66.7% Example 100% 100% 100% 100% 66.7% 66.7% 33.3% Example 4 100% 100% 100% 66.7% 66.7% 66.7% 33.3% Example 5 100% 100% 66.7% 66.7% 66.7% 66.7 % 33.3% Example 6 100% 100% 66.7% 33.3% 33.3% 33.3% 33.3% Example 7 66.7% 66.7% 33.3% 33.3% 33.3% 33.3% 33.3% Example 8 100% 100% 33.3% 33.3% 0% 0% 0% Example 9 100% 100% 100% 100% 100% 100% 100% In the experiment, nude mice were fed with nine pharmaceutical compositions. The experimental results showed that the nine pharmaceutical compositions of Examples 1 to 9 have protective effects on the brain tumor damage tested (ie, the range of brain tumors is reduced), and the survival rate of the nude mice is also improved after four weeks, that is, prevention of brain tumor suppression. Or therapeutic effect. - The above nine pharmaceutical compositions are all compound except for the examples. The pharmaceutical composition of the present invention is a pharmaceutical composition effective for treating brain tumor suppression. The above-described embodiments are merely examples for convenience of description, and the scope of the claims is intended to be limited to the above embodiments. [Simple diagram description] 13 1362937 None [Main component symbol description] Benefit «»»»
1414
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