TWI342220B - - Google Patents

Description

1342220 发明Invention Description: [Technical Field] The present invention relates to an oil-in-water emulsified composition containing an amphiphilic lipid, even at a low concentration of interfacial activity, and a method for producing the same The amphiphilic lipid has good emulsion stability and excellent use feeling. [Prior Art] In order to impart moisturization and softness to skin, mucous membranes, hair, and the like, moisture in the stratum corneum is important, which is a well-known fact. On the other hand, this stratum corneum acts as a barrier layer of a living body and exerts a function of water retention and water evaporation inhibition of the skin (stroke layer), which is also known. In recent years, the fact that intercellular lipids present in the stratum corneum of the skin have a significant correlation with the maintenance of keratinous water and barrier function has gradually been revealed. Therefore, in order to enhance the moisturizing effect, a cosmetic material in which an amphiphilic lipid such as a neuronamine (c e r a m i d e ) having a main component of an intercellular lipid present in the broad-spectrum layer and a similar substance is added has been proposed. However, since these amphiphilic lipids have low solubility in water, they remain solid when they are not at a high temperature, and therefore, especially when they are desirably formulated into an oily emulsified composition in water, Use a large amount of surfactant. Conversely, in general, the amount of surfactant (e.g., nonionic surfactant) used in the cosmetic material is desirably reduced as much as possible. On the other hand, the normal skin of a person is covered with a weakly acidic sebum film, and the contact of an alkaline substance from the outside is naturally controlled to naturally control the skin. For example, washing the skin epidermis with fatty acid soap will become weak 5 312 / invention instructions (supplement) / 92-12/92126607 1342220 alkaline, but in normal skin, natural neutralization via free fatty acids from sebum . That is, it is suitable for use as an external preparation for skin or a cosmetic material, and as far as possible, it is a weak acidity which is close to the normal skin of a person, and has a good influence on the skin, especially for those who are sensitive to the skin. Therefore, in a weakly acidic cosmetic material, a technique for stably adjusting an intercellular lipid component with a small amount of a surfactant is under review. A method for dissolving two amphiphilic lipids such as neural guanamines in a liquid having a melting point of less than 30 ° C is disclosed in Japanese Patent Laid-Open Publication No. Hei 2 0 0 2 - 1 1 4 6 3 1 . The oil and the aqueous medium formed in the oil are emulsified with a polyglycerin fatty acid ester to obtain a stable emulsified composition. However, in this method, if a stable emulsion is to be produced, a large amount of polyglycerin fatty acid ester is required to be equal to the amount of the amphiphilic lipid, and in order to obtain a weakly acidic emulsion, organic must be added. Acids such as acids are used to adjust the pH. Further, in Japanese Laid-Open Patent Publication No. Hei No. Hei-4- No. Hei No. Hei No. Hei. However, the amount of the surfactant used in this combination is also large, and in the acidic range of pH 6 or less, the anionic surfactant tends to be less likely to function as an emulsifier. Therefore, an object of the present invention is to provide an oil-phase emulsified which is excellent in the use of an oil phase which can stably emulsify an oleophilic lipid such as neuropterin which is usually difficult to prepare in an aqueous medium, and which can be stably emulsified at a low concentration of a surfactant. a composition, and a method of manufacturing the same. SUMMARY OF THE INVENTION The present inventors have discovered that a low concentration of interfacial activity can be achieved by using a combination of a specific cationic surfactant and a 6312/invention specification (supplement)/92-12/92126607 1342220 divalent or trivalent alcohol. The agent emulsifies the amphiphilic lipid in a stable manner, and an oil-in-water emulsion composition excellent in the feeling of use can be obtained. That is, the present invention provides an oil-in-water emulsion composition comprising: (A) at least one of a 4-stage ammonium salt type cationic surfactant represented by the following formula (、), and (B) two The at least one of the (C) divalent and trivalent alcohols and (D) water; and the content of the cationic surfactant (A) is 0.1 to 1% by mass. Furthermore, the present invention provides a method for producing an oil-in-water emulsion composition, characterized in that (A) at least one of a fourth-order ammonium salt type cationic surfactant represented by the following general formula (1), After mixing with at least one of (C) a divalent or trivalent alcohol, (B) an oil phase containing the amphiphilic lipid is added, and then an aqueous medium is added.

X- Formula (1) (wherein R 1 and R 2 are each a saturated or unsaturated hydrocarbon group having a straight or branched chain having a carbon number of 16 2 - 2 2 independently, and R 3 and R 4 are independently carbon numbers 1 The alkyl group of ~3, X_ is an anion forming a salt.) [Embodiment] The contents of the documents cited in the present specification are incorporated by reference as a part of the specification. The oil-in-water emulsion composition of the present invention is characterized in that (B) an oil phase containing an amphiphilic lipid and (C) an alcohol containing an alcohol selected from divalent and trivalent (hereinafter, referred to as an alcohol (C) )) an aqueous continuous phase obtained by (A) a 4-stage ammonium salt type cationic surfactant represented by the above formula (1), Table 7 312 / invention specification (supplement) / 92-12/92126607 1342220 ( Hereinafter, the emulsified composition obtained by emulsification is referred to as a cationic surfactant (A). The cationic surfactant (A) and the amphiphilic lipid (B) in the emulsified composition of the present invention are combined in an aqueous medium containing an alcohol (C) to form a liquid crystal (or an α-colloid structure). To form a thickened structure. The resulting thickened structure exhibits viscous behavior and can be stabilized for the combination of oil droplets and creaming. By such a combination, even if the cationic surfactant (A) has a low concentration, a liquid crystal structure having high stability can be formed. Therefore, the amount of the surfactant used can be reduced. Here, since the adhesion-promoting structure has optical anisotropy, it can be confirmed by a polarizing microscope or the like. Further, the emulsified composition of the present invention exhibits thixotropy. The above-mentioned thickened structure retains a stable liquid crystal structure in a standing state, but is liable to break the liquid crystal structure at the time of coating, and is thin and It is uniformly spread on the coating section, so it has a refreshing and fresh feeling of use. Further, the emulsified composition of the present invention is weakly acidic, and it is preferable from the viewpoint of the irritancy and feeling of use of the skin. Specifically, it is preferred that the pH is 4 or more and less than 7. In the present invention, by making a combination of the above components (A), (B), (C) and (D), a weakly acidic emulsification can be obtained even if the pH is adjusted to be acidic without addition of a pH adjuster. Composition. The cationic surfactant (A) used in the present invention is a cationic surfactant which may have a substituent of a 4-stage ammonium salt having a hydrocarbon group having two long chains in one molecule. As the cationic surfactant (A), particularly from the viewpoint of affinity for skin, the following general formula (1) 8 312 / invention specification (supplement) / 92-12/92 丨 2 < 3607 can be used. 1342220 indicated. X- Formula (1) R1\ r ί Λ (wherein R 1 and R 2 are each a saturated or unsaturated hydrocarbon group having a straight or branched chain having a carbon number of 16 to 2 2 independently, and R 3 and R 4 are respectively The alkyl group having a carbon number of 1 to 3 independently, and X is an anion forming a salt.) Examples of the hydrocarbon group R1 and R2 in the formula (1) include an alkyl group or an alkenyl group. Examples of the anion forming the salt include a halogen ion, a phosphoric acid ion, an acetic acid ion, a lactate ion, and a monoalkyl sulfate ion. Specific examples of the cationic surfactant include gasified dicetyldimethylammonium chloride, distearyldimethylammonium chloride, vaporized diaralkyldimethylammonium, and gasification two. Dibehenyl dimethyl ammonium and the like. Among them, vaporized dicetyldimethylammonium chloride and distearyldimethylammonium chloride are commercially available, and may be mentioned as Varisoft TA-432CG or Varisoft TA-100 (manufactured by Goldschmidt Co., Ltd.) 'Quartamin D-86P (manufactured by Kao Corporation). Among these surfactants, it is preferred to have vaporized cetyl dimethylammonium, vaporized distearyl dimethylammonium or the like in consideration of affinity to the skin. The content of the cationic surfactant (A) is considered from the viewpoint of forming a preferred liquid crystal structure together with the two affinic lipids (B) and the alcohol (C) described later, and the oily emulsified composition in water The total composition is preferably 〇. 1 to 1% by mass, and more preferably 0.5 to 1% by mass. The amphiphilic lipid (B) in the present invention refers to a substance having a hydrophilic portion and a hydrophobic portion in the molecule and being solid at 25 ° C. Examples of the parental lipid (B) include cholesterol, cholesteryl ester, cholesterol, and the like; stearic acid, palm sulphate, and the like. Higher alcohols such as acid, such as cetyl alcohol, stearyl alcohol, behenyl alcohol, squalyl alcohol (baty I a 1 ch ο I ), alcohol (chimy 1 a 1 coho 1 ), and related compounds; Esters and the like. Further, as the amphiphilic lipid which is excellent in barrier action and moisturizing action especially for the skin and which has an excellent effect of improving skin roughness, the indoleamine compound represented by the following general formulae (2) to (4):

R11-C - NH

II IO HC-CH2-〇H Formula (2) r12-ch-oh (wherein R 11 is a saturated or unsaturated group of 8 to 50 chains or branched chains which may be substituted by one or more hydroxyl groups. a hydrocarbon group, or a group represented by R13-C00-R, R13 is a linear or branched chain saturated or branched hydrocarbon group having 8 to 30 carbon atoms, and R14 is a linear chain having a carbon number which may be substituted by one or more hydroxyl groups. Or a saturated or unsaturated divalent hydrocarbon group of a branched chain. R12 is a saturated or unsaturated hydrocarbon group having a linear or branched chain of 8 to 50 carbon atoms which is substituted by one or more hydroxyl groups.) Gualoic acid: 鲛Hepatic glycerol, and the straight 4_ not full 8~40 can be and or 17 R R15-C-N-CH2

HU Formula (3) R16—CH2 (wherein a saturated or unsaturated hydrocarbon group which may be substituted with one or more hydroxyl groups and has 7 to 2 5 chains or branched chains is a carbon number which may be substituted by one hydroxyl group. 8 to 2 6 linear or branched chain saturated or not directly saturated 312 / invention specification (supplement) / 92-12/92126607 10 1342220 hydrocarbon or alkoxy. R17 is a hydrogen atom, 2-hydroxyl Ethyl or 2,3-dihydroxypropyl. Y is a hydrogen atom or a hydroxyl group.) Η Ο 〇Η Formula (4) r18-〇-R19-n-C-R20-C-N-R19-〇-R18

(wherein R 18 is a straight or branched hydrocarbon group having 1 to 2 carbon atoms which may be independently substituted by a hydroxyl group and/or an alkoxy group, and R 19 is independently a carbon number of 1 to 12; a divalent hydrocarbon group of a straight or branched chain, R 2 ° is a linear or branched chain divalent hydrocarbon group having a carbon number of 1 to 4 2 .

In the formula (2), R 11 is preferably a saturated or unsaturated hydrocarbon group of a linear or branched chain having 8 to 30 carbon atoms which may be substituted by one or more hydroxyl groups, or R 13 - C 0 0 - R 14 - the indicated group. Here, R 13 is preferably a linear or branched chain saturated or unsaturated hydrocarbon group having 8 to 30 carbon atoms, and R 14 is a linear chain having 8 to 30 carbon atoms which may be substituted by one or more hydroxyl groups. Or a saturated or unsaturated divalent hydrocarbon group of the branched chain is preferred. R12 is preferably a saturated or unsaturated hydrocarbon group having a linear or branched chain having 8 to 30 carbon atoms which may be substituted by one or more hydroxyl groups. In particular, it is preferred that RM and R13 are linear alkyl groups having 8 to 30 carbon atoms, and R14 is a linear alkyl group having 8 to 30 carbon atoms. The indoleamine compound represented by the formula (2) is preferably Robson KJet a 1 , J. Lipid Res., 35, 2060 (1994), and Wertz PW et al., J. Lipid. The neurosteroids of the types 1 to 7 described in Res., 24, 759 (1983) and the like. These can be automated plant extraction and modified via reaction, or by complete synthesis. Further, as a commercial product of the guanamine compound represented by the formula (2), there are mentioned: ceramide III, neural crest 11 312/invention specification (supplement)/92-12/921266〇7 1342220 amine I 1 IB, neuropterin IIIA, neuropterin IV, fit intercellular lipid I (above, manufactured by DEGUSSA), neuropterin II (manufactured by S ederma), and ceramide TIC - 0 0 1 (manufactured by Takasago Co., Ltd.) Wait. In the formula (3), R 15 is a saturated or unsaturated hydrocarbon group of a straight or branched chain having a carbon number of 14 to 2 2 which may be substituted by one or more hydroxyl groups, particularly a linear alkyl group. Better. Among them, a fluorenyl group and a trihydroxy quinone group are more preferred. R16 is preferably a linear alkyl group or alkoxy group having 8 to 24 carbon atoms. Among them, a fluorenyl group and a hexamethoxy group are particularly preferred. With respect to the combination of R16 and R17, when R17 is a hydrogen atom or a 2-hydroxyethyl group, R16 is preferably a linear alkoxy group, and when R11 is a 2,3-dihydroxypropyl group, R11 is linear. Alkyl is preferred. Further, in the combination of Y and R17, when R11 is a hydrogen atom or a 2-hydroxyethyl group, Y is preferably a hydroxyl group, and when R17 is a 2,3-dihydroxypropyl group, Y is preferably an argon atom. Specific examples of the guanamine compound represented by the formula (3) include compounds represented by the following formulas (5), (6) and (7).

Formula (5)

312/Invention Manual (Supplement)/92-12/92] 26607 12 1342220 Further, the indoleamine compound of the formula (3) can be described in Japanese Patent Laid-Open Publication No. SHO-6-2-2880 or the like. The method is produced; for example, a method in which a reaction product obtained from glycidyl ether and ethanolamine is deuterated, and then an ester group is selectively hydrolyzed. Among them, a guanamine compound represented by the formula (5) is preferred, which is sold under the trade name of Sofcare ceramide SL-E (N-3-hexamethylene-2-hydroxypropyl)-N-2-hydroxyl Ethyl hexamethyleneamine, Kao (share)) is sold on the market. R 18 which is a guanamine compound represented by the formula (4), which has a carbon number of 1 to 2 2 which may be substituted by 1 to 3 groups selected from a hydroxyl group and an alkoxy group having 1 to 6 carbon atoms Or an alkyl group of a branched chain is preferred, and a hydroxyl group and an alkoxy group may be simultaneously substituted. Preferred are, for example, an alkyl group having 1 to 18 carbon atoms, a mono or dihydroxyalkyl group having 1 to 8 carbon atoms, and an alkyl group having a carbon number of 1 to 18 substituted with an alkoxy group having 1 to 6 carbon atoms. And an alkyl group having 1 to 18 carbon atoms which is substituted with a hydroxyl group and an alkoxy group having 1 to 6 carbon atoms. More preferably, it is an alkyl group having 1 to 18 carbon atoms, a mono or dihydroxyalkyl group having 2 to 12 carbon atoms, and an alkyl group having 2 to 12 carbon atoms substituted by an alkoxy group having 1 to 6 carbon atoms. And a C 2 to 12 alkyl group substituted with a hydroxyl group and an alkoxy group having 1 to 6 carbon atoms. Among them, as R18, a 2-hydroxyethyl group, a decyl group, a lauryl group or a 2-methoxyethyl group is more preferable. R 19 is preferably a "linear or branched chain of carbon number 1 to 12 2", and a linear or branched alkyl group having 2 to 6 carbon atoms is more preferable. Among them, especially ethylidene and trimethylene are preferred. R2 ° is preferably a linear or branched chain divalent hydrocarbon group having 2 to 3 carbon atoms, and a linear or branched chain alkyl group having 2' 3 4 carbon atoms or having 1 to 4 double bonds. It is more preferred to extend the alkenyl group, especially the alkyl or branched chain alkyl group having a carbon number of 2 to 2 4 or 13 312 / invention specification (supplement) / 92-12/92126607 1342220 The extended alkenyl group of the bond is particularly preferred. Among them, preferred are: 7,] 2 -diindolyl octadecyl, 7,12-dimethyl-7, fluorene-exodecyl diallyl. 'Extension of the 18th base, Shen Xinji' stretches the base, stretches the eleven carbon base, and extends the thirteen carbon base. As the guanamine compound represented by the formula (4), a compound in which R 18 , R 1 s, and RM are each in a preferred range described above is a preferred compound of the formula (4). For example, the compound can be reacted with an amine by reacting a corresponding dicarboxylic acid or a reactive derivative thereof (ester, acid halide, acid anhydride, etc.) with an amine, for example, as described in International Publication No. 6/2006. Condensation is carried out to produce it efficiently. The amphiphilic lipid used in the oil-in-water emulsion composition of the present invention, in particular, a compound represented by the following formula (8) to formula (14) which is a guanamine compound represented by the formula (4) It is especially good.

丨~OH

〇 ch3 η (9) H CH3 Ο

, ~〇Η (1 0 )

0 CH3 η H CH3 Ο 14 312/invention manual (supplement)/92-12/92] 26607 1342220 C! 2^25. ~Μ

Equation (13) ch3o ~

The content of the amphiphilic lipid of the formula (14 (B) is preferably 0.1% by mass or more, based on the total composition of the oil-type emulsified composition in the water, in order to exert a barrier effect on the skin and a moisturizing effect. If the balance between the stability and the preservation stability is taken into consideration, it is more preferably 0.1% to 20% by mass in the total composition, particularly preferably 0.1 to 1% by mass. Further, the cationic type The mass ratio (A: B) of the surfactant (A) to the amphiphilic lipid (B) is considered to be the effect on the skin and the formation of a preferred liquid crystal structure, from 1 0 : 1 to 1 : 20 is preferable, and 1 0 : Bu 1 ·· 1 0 is more preferable. In the present invention, the alcohol (C) selected from the group consisting of divalent and trivalent alcohols may be formulated into an emulsified cosmetic material. The cationic surfactant is dissolved and dispersed. The cationic surfactant (A) is mixed with the alcohol (C) and then mixed with the oil component containing the amphiphilic lipid (B), even if the cationic interface is active. A preferred liquid crystal structure can be formed at a low concentration. Examples of such an alcohol (C) include ethylene glycol and polycondensation. Ethylene glycol (average molecular weight 200-400), propylene glycol, dipropylene glycol, 1,3-butanediol, glycerin, polyglycerol (degree of polymerization 2 ~ 5), etc. Among them, glycerin and ethylene glycol are more preferred. The content of the compound (C) is considered to have a good feeling of use, a liquid crystal structure can be formed, and a stable emulsion can be obtained, and is determined to be 5 in the total composition of the oily emulsified composition in water. ～40% by mass is preferred, especially 15 312/invention specification (supplement)/92-12/92126607 1342220 is more preferably 5 to 20% by mass. In the oil-in-water emulsified composition of the present invention, In addition to the amphiphilic lipids, it may also contain liquid or semi-solid solid synthetic oils and oily components of natural origin used in general cosmetic materials, such as hydrocarbon oils, esters, oils, and polysulfonates. Examples of the liquid oil include vegetable oils such as load-bearing oils; animal oils such as lanolin; hydrocarbon oils such as liquid paraffin and squalane; and bis-stearate and lactic acid. Dodecyl ester, isodecyl isocyanurate isooctyl citrate, octyl dodecyl myristate, Ester oils such as neodecanoic acid esters; glycerin derivatives, amino acid derivatives, dimethyloxane, dimethylcyclopolyoxyalkylene, decyl-based polyoxyalkylene, mercapto-polyene polyoxyalkylene a polyfluorinated fluorinated polycondensate such as a higher alcohol modified organic polyoxyalkylene, a fluorine oil such as a perfluoro fluorinated domain, and a pulverized oil such as a crushed oxygen. Examples of the oily component of a solid or semi-solid may be, for example, a charge. Plant waxes such as glyceryl monostearyl ether, glycerol monocetyl ether, etc.: petrolatum, lanolin, pure ceresin, microcrystalline wax, carnauba wax, candel tree 蝎Candelilla wax) and other classes. The content of these oily components is usually 0% by mass in the total composition, and preferably 1 to 20% by mass. Further, in the emulsified group for the purpose of preventing ultraviolet rays (U V ) cosmetic materials, a U V agent called a U V absorbent or a U V dispersing agent can be appropriately contained. As the UV absorber, p-methoxy cinnamic acid type, diphenyl type, 4-imidazole acrylic type, p-amino benzoic acid type, salicylic acid type, 312/invention specification (supplement)/92-12/ can be used. 92126607 (B) body or oil, liquid fruit acid ester, pentane dimerization hydrogenated oil; wax wax alkane black brown wax 30 adult protective ketone phenyl hydrazine 16 1342220 methane system, three. As a dispersing agent, a compound such as a phthalic acid or an o-aminobenzoic acid can be used as a powder of titanium dioxide, zinc oxide or iron oxide. The content of such a U V protective agent is usually from 1 to 40% by weight in the total composition, and preferably from 1 to 20% by mass. This anti-UV cosmetic material is made of an oil-based emulsified composition in water to make it resistant to water and is not easily detached by sweat or water, and has a good UV-preventing effect. The content of the water (D) in the aqueous phase in which the oil-based emulsified composition is formed in the present invention is usually from 10 to 90% by mass in the total composition, and preferably from 40 to 90% by mass. The water phase component other than water may be blended with a water-soluble component usable in a general cosmetic material other than the above-mentioned alcohol, such as ethanol or water-soluble, within a range that does not impair the purpose and effect of the present invention. Sexual medicinal agents, anti-drying agents, preservatives, bactericides, salts, base acids, sugars, chelating agents, tackifiers, pigments, perfumes, etc. The oil-in-water emulsion composition of the present invention is preferably obtained by adding at least one of at least one of the cationic surfactant (A) to at least one of the alcohols (C). a second step of adding an oily dispersed phase having two amphiphilic lipids (B) to the mixture obtained in the first step; and adding an aqueous medium to the mixture obtained in the second step The third step. The mixture obtained by adding an alcohol such as glycerin to a cationic surfactant is mixed with an oil containing an amphiphilic lipid, and then added to an aqueous phase containing an aqueous component other than the emulsified component, thereby emulsification. The oil phase containing the amphiphilic lipid is separated into a stable emulsified state. 312 / invention specification (supplement) / 92-12/92126607 UV quality and other protective phase and the formation of the mixed alcohol with each ammonia has 17 1342220, that is, by preparing the emulsified composition in the above order, cationic surface activity The agent and the amphiphilic lipid form a thickened structure obtained by forming a liquid crystal structure in a polyol, and the oil droplets can be combined and defrosted. Here, when the amphiphilic lipid (B) is mixed with a component such as an oil component, in order to improve the solubility or dispersibility, it may be heated as needed. The oil-in-water emulsion composition of the present invention exhibits an emulsion-like or creamy appearance, and preferably has a viscosity at 25 ° C of 1,000 to 100,000 mPa·s. Also, the viscosity can be measured by a B-type viscometer. The oil-in-water emulsion composition of the present invention is useful as an external preparation or a chemical, and is particularly useful as a cosmetic material, and can be used as an emulsion, a gel, a cream, an ultraviolet protection cosmetic, an air jet, etc. Any dosage form. (Examples) The present invention will be further illustrated by the following examples, and the embodiments of the invention will be described. However, the illustrated embodiments are for illustrative purposes only and are not to be construed as limiting the invention. Also, the notes in the table are as follows: Wood 1: Kao (share), Sofcare ceramide SL-E Timber 2: Goldschmidt, Varisoft TA-100 *3: Goldschmidt, Varisoft BT-85 *4: Kao (share), EXCEPARL Ai Jixibal DG-MI *5: Shin-Etsu Chemical (share), SILICONE KF-96A (10cs) (evaluation project) 312 / invention manual (supplement) / 92-12/92 丨 26607 type boundary, and stability other In the process of making a cosmetic product of milk, the solution of the present formula is 18 1342220 (1) The formation of a thickened structure. A small amount of the emulsified composition is placed on a glass slide, and after covering the cover glass, The optical anisotropy was confirmed by a polarizing microscope (Nikon Corporation, ECLIPSE E600 P0L). (2) Appearance When the state in which the emulsified composition was prepared was a uniform emulsified state, it was judged as "good", and when it was found that there was separation, it was judged as "separation". Then, about 40 g of the emulsified composition was placed in a 500 ml wide glass jar, and after 1 month of storage in a thermostat at 50 ° C and 5 ° C, the emulsified state was as follows. The baseline is visually observed. <Evaluation Criteria> 〇: Separation △ can not be seen: It can be seen that there are some separations X: obvious separation can be seen (degree of problem in the characteristics of the finished product) (3) Viscosity measurement will emulsify the composition about 40 g A 50 ml wide glass jar was placed, kept in a water bath at 25 ° C, and all the parts except the cap were immersed, and kept in this state for 2 hours. Immediately after the lapse of 2 hours, the glass bottle was taken out from the water bath, and the viscosity was measured with a B-type viscometer (type B8R, manufactured by Tokyo Keiki Co., Ltd.) to determine the viscosity at 25 °C. (4) p Η measurement The emulsified composition was placed in a covered glass bottle, and immersed in a water bath maintained at 25 ° C for 2 hours, and the glass bottle was taken out from the water bath, and then used as a pH meter (Η 0 RIBA company, ρ Η Μ ETERF - 2 2 ) Determination. 19 312 / invention specification (supplement) / 92-12/92126607 1342220 Slim adhesion structure. This production method can obtain a weakly acidic emulsified composition without particularly adjusting the pH, and is therefore advantageous in terms of productivity.

25 312/Invention Manual (supplement)/92-12/92126607

Claims (1)

1342220 y The oil-in-water emulsion composition is characterized in that it is at least one of a quaternary ammonium salt type cationic type represented by the following general formula (1); (B) from stearyl alcohol, hawthorn Alcohol, shark liver alcohol, isostearyl tetradecyl glycerol and the following formula (5) constitute at least one diol, polyethylene glycol of the selected amphiphilic lipid in the group (average At least one of a divalent or trivalent alcohol selected from the group consisting of a molecular weight of 200 to 400), propylene glycol alcohol, 1,3-butanediol, glycerin, and polyglycerol (degree of polymerization: 2 to 5); and (D) water; The content of the sub-type surfactant (A) is 0.1 to 1% by mass, the content of the pro-lipid (B) is 0.1 to 20% by mass, and the content of the above-mentioned divalent and (C) is 5 to 40%. %%; ® 〇5 lion replacement will have: (A) surfactant alcohol (baty 1 amide combination; (C) from the above-mentioned cations of the amphiphilic trivalent alcohol in the group B and dipropyl R\ /R3 八R2 R4 X Formula (1) (wherein R 1 and R 2 are each independently a linear or saturated or unsaturated hydrocarbon group having a carbon number of 16 to 2 2 , and R 3 and R 4 are each independently a carbon number group. , X is the formation of salty Yin Hexamethyleneimino) branched chain of 1 to 3 2. The structure of the water-oil type emulsified composition of the first application of the patent scope is pH 4 or more and less than 7. 26 3 26\总档\92\92126607X92126607 (replacement)-2 1342220 3. A method for producing an oily type emulsified composition, characterized in that it comprises the following steps: (A) is represented by the following formula (1) At least one of the four-stage ammonium salt type cationic surfactants represented by (C), ethylene glycol, polyethylene glycol (average molecular weight: 200 to 400), propylene glycol, dipropylene glycol, and 1,3-butanediol , glycerin, polyglycerol (degree of polymerization 2 - 5 ) constituting at least one of the selected divalent and trivalent alcohols in the group, and then added to contain (B) from stearyl alcohol, behenyl alcohol, shark liver A batyl alcohol, an isostearyl tetradecyl glycerin, and an guanamine compound represented by the following formula (5) constitute an oil phase of at least one selected from the group consisting of an amphiphilic lipid, and then an aqueous medium is added. And using the above-mentioned respective components (A), (B), and (C) in the following ratio based on the total amount of the final composition; the content of the cationic surfactant (A) is 0.1 to 1% by mass; The content of the amphiphilic lipid (B) is 0.1 to 20% by mass; and the content of the above-mentioned divalent and trivalent alcohol (C) 5 to 40% by mass; 'R\ /R3 [/ V (wherein R1 and R2 are each independently a saturated or unsaturated hydrocarbon group of a straight or branched chain having a carbon number of 16 to 22, and R3 and R4 are each independently a carbon number of 1 to 3; Alkyl, X - is an anion forming a salt) 27 326Y total file \92\92126607\92126607 (replace)-2