TWI254710B - Thienyl substituted acylguanidines as inhibitors of bone resorption and vitronectin receptor antagonists - Google Patents
Thienyl substituted acylguanidines as inhibitors of bone resorption and vitronectin receptor antagonists Download PDFInfo
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- TWI254710B TWI254710B TW090121555A TW90121555A TWI254710B TW I254710 B TWI254710 B TW I254710B TW 090121555 A TW090121555 A TW 090121555A TW 90121555 A TW90121555 A TW 90121555A TW I254710 B TWI254710 B TW I254710B
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98109077A EP0960882A1 (en) | 1998-05-19 | 1998-05-19 | Thienyl substituted acylguanidines as inhibitors of bone resorption and vitronectin receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TWI254710B true TWI254710B (en) | 2006-05-11 |
Family
ID=8231959
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW090121555A TWI254710B (en) | 1998-05-19 | 1999-08-18 | Thienyl substituted acylguanidines as inhibitors of bone resorption and vitronectin receptor antagonists |
| TW088108141A TW546294B (en) | 1998-05-19 | 1999-08-18 | Thienyl substituted acylguanidines as inhibitors of bone resorption and vitronectin receptor antagonists |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW088108141A TW546294B (en) | 1998-05-19 | 1999-08-18 | Thienyl substituted acylguanidines as inhibitors of bone resorption and vitronectin receptor antagonists |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6566366B1 (OSRAM) |
| EP (2) | EP0960882A1 (OSRAM) |
| JP (1) | JP4503176B2 (OSRAM) |
| AR (1) | AR018358A1 (OSRAM) |
| AT (1) | ATE322490T1 (OSRAM) |
| AU (1) | AU4138599A (OSRAM) |
| DE (1) | DE69930740T2 (OSRAM) |
| TW (2) | TWI254710B (OSRAM) |
| WO (1) | WO1999059992A1 (OSRAM) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6965165B2 (en) | 1998-12-21 | 2005-11-15 | Mou-Shiung Lin | Top layers of metal for high performance IC's |
| US7381642B2 (en) | 2004-09-23 | 2008-06-03 | Megica Corporation | Top layers of metal for integrated circuits |
| US7405149B1 (en) | 1998-12-21 | 2008-07-29 | Megica Corporation | Post passivation method for semiconductor chip or wafer |
| EP1187825A1 (en) * | 1999-06-07 | 2002-03-20 | Shire Biochem Inc. | Thiophene integrin inhibitors |
| EP1108721A1 (en) * | 1999-12-15 | 2001-06-20 | Aventis Pharma Deutschland GmbH | Thienylalanine derivatives as inhibitors of cell adhesion |
| FR2806082B1 (fr) * | 2000-03-07 | 2002-05-17 | Adir | Nouveaux composes bicycliques antagonistes des recepteurs de la vitronectine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| DE10041428A1 (de) * | 2000-08-23 | 2002-03-07 | Merck Patent Gmbh | Biphenylderivate |
| DE10061876A1 (de) * | 2000-12-12 | 2002-06-20 | Aventis Pharma Gmbh | Arylierte Furan- und Thiophencarbonsäureamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| AU2002344854B2 (en) * | 2001-06-11 | 2008-11-06 | Vertex Pharmaceuticals (Canada) Incorporated | Thiophene derivatives as antiviral agents for flavivirus infection |
| US8329924B2 (en) * | 2001-06-11 | 2012-12-11 | Vertex Pharmaceuticals (Canada) Incorporated | Compounds and methods for the treatment or prevention of Flavivirus infections |
| CN100413861C (zh) * | 2002-12-10 | 2008-08-27 | 维勒凯姆制药股份有限公司 | 用于治疗或预防黄病毒感染的化合物 |
| TW200418825A (en) * | 2002-12-16 | 2004-10-01 | Hoffmann La Roche | Novel (R)-and (S) enantiomers of thiophene hydroxamic acid derivatives |
| US20050107350A1 (en) * | 2003-08-22 | 2005-05-19 | Pharmacia Corporation | Method for the treatment or prevention of bone disorders with a cyclooxygenase-2 inhibitor alone and in combination with a bone disorder treatment agent and compositions therewith |
| GB0412553D0 (en) | 2004-06-04 | 2004-07-07 | Univ Aberdeen | Therapeutic agents for the treatment of bone conditions |
| UA87854C2 (en) | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
| CN101218224B (zh) * | 2005-05-13 | 2013-05-08 | Viro化学制药公司 | 治疗或预防黄病毒感染的组合物和方法 |
| PT2104674E (pt) | 2006-11-15 | 2013-07-26 | Virochem Pharma Inc | Análogos de tiofeno para o tratamento ou prevenção de infeções por flavivírus |
| GB0705400D0 (en) | 2007-03-21 | 2007-05-02 | Univ Aberdeen | Therapeutic compounds andm their use |
| GB0817207D0 (en) | 2008-09-19 | 2008-10-29 | Pimco 2664 Ltd | therapeutic apsac compounds and their use |
| GB0817208D0 (en) | 2008-09-19 | 2008-10-29 | Pimco 2664 Ltd | Therapeutic apsap compounds and their use |
| GB201311361D0 (en) | 2013-06-26 | 2013-08-14 | Pimco 2664 Ltd | Compounds and their therapeutic use |
| JPWO2015137408A1 (ja) * | 2014-03-11 | 2017-04-06 | Ｅａファーマ株式会社 | ヘテロアリールカルボン酸エステル誘導体の製造方法及びその製造中間体 |
| ES2864079T3 (es) | 2014-05-30 | 2021-10-13 | Pfizer | Derivados de carbonitrilo como moduladores selectivos del receptor de andrógenos |
| LT3262028T (lt) | 2014-12-17 | 2022-01-10 | Pimco 2664 Limited | N-(4-hidroksi-4-metil-cikloheksil)-4-fenil-benzensulfonamido ir n-(-4-hidroksi-4-metil-cikloheksil)-4-(2-piridil)-benzensulfonamido junginiai ir jų terapinis panaudojimas |
| WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
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| US5125050A (en) * | 1991-05-03 | 1992-06-23 | Bell Communications Research, Inc. | Vertical metallically loaded polarization splitter and polarization-diversified optical receiver |
| US5204350A (en) * | 1991-08-09 | 1993-04-20 | Merck & Co., Inc. | Method of inhibiting osteoclast-mediated bone resorption by administration of n-heterocyclicalkyl-substituted phenyl derivatives |
| JP3322878B2 (ja) * | 1992-10-14 | 2002-09-09 | メルク エンド カンパニー インコーポレーテッド | フィブリノーゲンレセプターアンタゴニスト |
| CA2190870A1 (en) * | 1994-05-27 | 1995-12-07 | George D. Hartman | Compounds for inhibiting osteoclast-mediated bone resorption |
| FR2742752B1 (fr) * | 1995-12-21 | 1998-01-30 | Adir | Nouveaux composes du thiophene, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| DE19629816A1 (de) * | 1996-07-24 | 1998-01-29 | Hoechst Ag | Neue Cycloalkyl-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten |
-
1998
- 1998-05-19 EP EP98109077A patent/EP0960882A1/en not_active Withdrawn
-
1999
- 1999-05-05 JP JP2000549611A patent/JP4503176B2/ja not_active Expired - Lifetime
- 1999-05-05 AU AU41385/99A patent/AU4138599A/en not_active Abandoned
- 1999-05-05 DE DE69930740T patent/DE69930740T2/de not_active Expired - Lifetime
- 1999-05-05 WO PCT/EP1999/003064 patent/WO1999059992A1/en not_active Ceased
- 1999-05-05 US US09/700,655 patent/US6566366B1/en not_active Expired - Lifetime
- 1999-05-05 EP EP99924879A patent/EP1086098B1/en not_active Expired - Lifetime
- 1999-05-05 AT AT99924879T patent/ATE322490T1/de not_active IP Right Cessation
- 1999-05-17 AR ARP990102334A patent/AR018358A1/es unknown
- 1999-08-18 TW TW090121555A patent/TWI254710B/zh not_active IP Right Cessation
- 1999-08-18 TW TW088108141A patent/TW546294B/zh not_active IP Right Cessation
-
2002
- 2002-11-14 US US10/368,771 patent/US6660728B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1086098B1 (en) | 2006-04-05 |
| AU4138599A (en) | 1999-12-06 |
| EP0960882A1 (en) | 1999-12-01 |
| DE69930740D1 (en) | 2006-05-18 |
| WO1999059992A1 (en) | 1999-11-25 |
| JP2002515500A (ja) | 2002-05-28 |
| AR018358A1 (es) | 2001-11-14 |
| US6566366B1 (en) | 2003-05-20 |
| JP4503176B2 (ja) | 2010-07-14 |
| TW546294B (en) | 2003-08-11 |
| EP1086098A1 (en) | 2001-03-28 |
| DE69930740T2 (de) | 2007-04-12 |
| US6660728B2 (en) | 2003-12-09 |
| US20030153557A1 (en) | 2003-08-14 |
| ATE322490T1 (de) | 2006-04-15 |
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| MM4A | Annulment or lapse of patent due to non-payment of fees |