TW546149B - Antibacterial compositions - Google Patents

Abstract

Antibacterial compositions having excel-lent antibacterial effectiveness are disclosed. The antibacterial compositions contain a polyhydric solvent, a hydrotrope, a surfactant, an optional antibacterial agent, and water.

Description

546149 A7 V. Description of the invention (The related application is related to the application. On June 23, 1999, the application filed by Shen She from the US patent application case of “M hitting the barrier fish” is called O9 / 338,654. -Japanese invention, related-an antibacterial composition, just like a personal care composition-= has better resistance to this force. More specifically, this hairpin is related to antibacterial, and a substance which includes a polyhydroxy solvent. A solvent, a surfactant, and an optional antibacterial agent, which can provide substantial, such as greater than 99%, the number of Gram-positive and Gram-negative bacteria within one minute. BACKGROUND OF THE INVENTION Antibacterial individuals Maintenance compositions are known in the art. Particularly useful are antibacterial cleansing compositions, which are typically used to clean the skin to kill bacteria and other microorganisms on the surface of the skin, especially the user's hands, arms and face. Another type of antibacterial personal care composition is hand disinfection gel. This type of composition is mainly used by medical personnel to disinfect hands and fingers. Hand hygiene gel is used to apply and rub on hands and fingers, and then apply The composition of the invention evaporates from the skin. Antibacterial compositions are generally used in, for example, the health care industry, the food service industry, the meat processing industry, and the private sector of individual consumers. The widespread use of antibacterial compositions illustrates the consumer's need for skin control The importance of the surface bacterial flora and other microflora. However, the important point is that the antibacterial composition can quickly and substantially decay the microflora without accompanying the problems of toxicity and skin irritation. -4 This paper is applicable to China National Standard (CNS) A4 Specification (210 X 297 mm) -------- ^ --------- (Please read the notes on the back before filling this page) Intellectual Property Bureau of the Ministry of Economic Affairs Printed by the Employee Consumer Cooperative-ϋ ϋ ϋ I ϋ 546149 A7 B7 V. Description of the invention (2) The cleaning composition typically contains an active anti-surfactant in an aqueous carrier, and various other ingredients, such as dyes, Perfume, pH adjuster, thickener, skin conditioner, etc. Several different types of antibacterial agents have been used in antibacterial cleansers. Traditional antibacterial agents include biguanides (for example, ehlorhe xidine digluconate), biphenyl compounds, benzyl alcohol, trihalocarbanilides, quaternary ammonium compounds, ethoxylated phenols, and phenol compounds, such as sulfanilin-substituted compounds such as Test) and tricloxasan (that is, 2,4,4, trichloro-2, _hydroxy-diphenyl ether). Antibacterial compositions based on these antibacterial agents are now exhibiting a wide range of antibacterial activity, from Low to high, depends on the microorganisms to be controlled and the special antibacterial composition. However, most commercial antibacterial compositions generally provide only low to moderate antibacterial activity. Antibacterial activity is achieved by combating microbes from Guangfanyuan including Gram Positive and Gram-negative microorganisms were evaluated. The logarithmic decay, or percentage attenuation, of the flora provided by the antibacterial composition is associated with antibacterial activity. For a particular contact time, generally from 15 seconds to 5 minutes, the logarithmic attenuation 3 of 3-5 is the best, the logarithmic attenuation of __3 is the better, and the logarithmic attenuation of less than 1 is Worse. Therefore, the highly preferred antibacterial composition exhibits a logarithmic reduction of 3-5 against the antimicrobials of Guangfanyuan within a short contact time. It must be noted that the logarithmic attenuation of the height 値 is obtained at pH 値 4 and 9, but at least part of them can be obtained because of these rather extreme p Η 値. Compositions with such ρ η 値 can irritate the skin and other surfaces and are therefore typically avoided. Use about 5 to about 8, special -5- This paper size applies Chinese National Standard (CNS) A4 specification (21 × X 297 mm) (Please read the precautions on the back before filling this page) Staff of the Intellectual Property Bureau of the Ministry of Economic Affairs Printed by Consumer Cooperatives

Order 丨 III I ---— — — — — — — — — ^ ------ I 546149 Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs A7 B7 V. Description of the invention (3 types It is difficult to achieve a very low logarithmic decay of the antibacterial composition at a neutral pH of about 6 to about 8. For example, the composition disclosed by WO_mo includes __, a surfactant, a solvent, and a chelating agent. , Thickener, buffer, and water. W98 / 0111〇 is related to reducing skin irritation by reducing the amount of surfactant.

Fendler et al. U.S. Patent No. 5,635,462 discloses compositions containing pcMx and selected surfactants. The composition disclosed therein does not contain anionic surfactants and non-ionic surfactants. The compositions disclosed in WO 97/46218 and WO 96/06152 are organic acids or salts of tdclosan's, solubilizers, and borrow solvents. EP 0 505 935 discloses a composition containing pC] V [X in combination with a nonionic and anionic surfactant, especially a nonionic block copolymer surfactant. WO 95/32705 discloses a mild surfactant composition which can be combined with antibacterial compounds such as triclosan. WO 95/09605 discloses an antibacterial composition comprising an anionic surfactant and an alkyl polysaccharide surfactant. WO 98/55096 discloses an antimicrobial wipe having a porous sheet impregnated with an antibacterial composition containing an active antimicrobial agent, an anionic surfactant, an acid, and water, wherein the composition has about 3.0 to about PH pH 6.0 NA Allawala et al. J. Amer. Pharm. Assoc. — Sci. Ed. Vol · XLII · No. 5 · ρρ · 267-275, (1953) discusses active antibacterial agents and interfacial activity -6- This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) (Please read the precautions on the back before filling this page)

546149 Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs A7 -----— B7 —_____ V. Description of the Invention (4) Antibacterial activity after combination of sex agents. A.G. Mitchell, J. Pharm. Pharmacol. Vol. 16, pp. 533-537, (1964) discloses a composition containing PCMX and a nonionic surfactant exhibiting antibacterial activity. The composition disclosed in Mitchell's article must exhibit antibacterial activity after a contact time of at least 47 minutes, and therefore, the composition of the present invention is not highly potent. Previous disclosures have relied on the presence of traditionally active antibacterial agents (eg, compounds) in the composition but have not addressed the question of which composition component of the antibacterial composition is providing a bacterial controller. Previous compositions also failed to provide an effective, fast, broad-acting type at a neutral pH of about 5 to about 8, especially at a pH of about 6 to about 8, and especially in the absence of an active antibacterial agent. Effect of bacterial control. Due to the nature of the antibacterial agent and the effect of the surfactant on the antibacterial agent, it is difficult to obtain an effective antibacterial composition. For example, there are several conventional active antibacterial agents, such as Miscellaneous, which have very low solubility in water. For example, tricolsan has a degree of dissolution in water of about 5 to 10 ppm (parts per million parts). Adding a surfactant to the composition can increase the solubility of the antibacterial agent. However, the increase in the degree of degradation of the antibacterial agent 'and conversely, the amount of the antibacterial agent in the composition also increases correspondingly, which does not necessarily increase the antibacterial efficacy. Without being bound by any particular theory, it is inferred that the addition of a surfactant will increase the solubility of the antibacterial agent but also typically reduces the utilization of the antibacterial agent because the surfactant in water will be above the threshold of the surfactant Colloidal particles are formed at the concentration of colloidal particles. The critical gel particle concentration varies from one surfactant to another. The formation of colloidal particles is important. The paper size applies the Chinese National Standard (CNS) A4 specification (21 × 297 mm) (Please read the precautions on the back before filling this page)

546149 Printed by A7 B7, Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs. 5. Description of the Invention (5), because the lipophilic area of the colloidal particles can attract and solubilize the antibacterial agent, so that the antibacterial agent cannot contact the bacteria immediately, and The reason is that bacteria cannot be controlled in a short time (that is, one minute or less). The antibacterial agent dissolved in the surfactant gel particles can also be used, but the bacteria must be controlled for a relatively long time. The antibacterial agent, if it exists freely in the aqueous solution and is not bound by the surfactant gel particles (that is, activated ones), will be attracted by the lipophilic membrane of the bacteria and quickly complete its function. If the antibacterial agent is bound by the surfactant gel particles (that is, not activated), the antibacterial agent can only slowly perform its function and cannot perform its function in a short time practical for cleaning the skin. In addition, the antibacterial agent dissolved in the gel particles can be easily washed off the skin during the rinsing process, and cannot be deposited on the skin surface to provide residual antibacterial benefits. Instead, the antibacterial agent is washed away and wasted. In summary, there is a need for an antibacterial composition that can highly effectively combat broad-spectrum Gram-positive bacteria and Gram-negative bacteria in a short time, and wherein the antibacterial activity is basically, or exclusively, This is due to the presence of composition ingredients that are different from traditional active antibacterial agents. The present invention relates to their antibacterial compositions. SUMMARY OF THE INVENTION The present invention relates to antibacterial compositions which are capable of substantially attenuating Gram-positive and Gram-negative bacteria in less than about one minute. More specifically, the present invention relates to an antibacterial composition containing a polyhydroxy solvent, a solubilizer, a surfactant, water, and an optional active antibacterial agent. In the preferred embodiment, the present invention relates to a solvent containing a polyhydroxyl, a solubilizer, and a boundary -8-(Please read the note on the back? Matters before filling out this page)

546149

Antimicrobial composition of 1,7k, i,, W, and an active antibacterial agent, wherein the antibacterial agent exhibits a content of at least 2% saturation when measured at room temperature. Accordingly, an aspect of the present invention is to provide an antibacterial composition comprising: (), ′ 1% by weight to about 50% by weight. /. (B) about 1% by weight to about 50% by weight. /. (C) a surfactant from about 1% to about 25% by weight; (d) from about 0% to about 5% by weight of an antimicrobial agent; and (e) water. Another aspect of the present invention is to provide an effective antibacterial composition which does not contain traditional active antibacterial agents, such as phenol, but contains a polyhydroxy solvent, solubilizer and surfactant as ingredients of the composition, which can effectively and quickly reduce the flora . Another aspect of the present invention is to provide an effective antibacterial composition containing a polyhydric alcohol, a solubilizer, and an anionic surfactant, but it does not contain a conventional active antibacterial agent. Another aspect of the present invention is to provide an antibacterial composition comprising a polyhydroxyl agent, a solubilizing agent, and a surfactant, wherein the weight ratio of the solubilizing agent to the light-based solvent is about 1: 1 to about 6: 1. . The preferred is about 2: 1 to about 4: 1, and the surfactant is selected from the group consisting of anionic surfactants, cationic surfactants, nonionic surfactants, amphoteric surfactants, and other surfactants. And so on. Another aspect of the present invention is to provide an antibacterial composition containing a polyhydroxy solvent, a solubilizer, a surfactant, and an active antimicrobial agent, wherein the content of the active antibacterial agent measured at room temperature is at least 2% and preferably Those are at least 25% saturated. This paper size is in accordance with Chinese National Standard (CNS) A4 (210 X 297 mm) (Please read the notes on the back before filling out this page}.: Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs 546149 A7 B7

Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs. Another aspect of the present invention is to provide an antibacterial touch that exhibits at least 2 /. A (S · aureus)) log decay 値. The color grape, another aspect of the invention, is to provide a logarithmic decay of 至少 (Eϋ) at least 30 seconds after exposure. (Τ Ρ aniseed present invention further - provide a monovalent Zhi aspect based on the gram-positive Μ i port # milk Twenty exhibit substantial ^ Bian, granary and Gram-negative bacteria and Zhi logarithmic decrement of about 5 to give ΡΙί 値 of about 8. ^ ^ ugly = on the other hand is to provide consumer products which are based on the antibacterial of the present invention: oral macchi and which are, for example, skin cleansers, body lotions? Mouth care agents, hand disinfection Bactericidal gel, disinfection of two and two water, dragon substance shampoo, hard surface disinfectant and bactericide, etc. =: Wannian provides a method to reduce Gram-positive and / or Gram-negative bacteria in animal tissues, including human tissues A method of swarming, which involves contacting a tissue, such as a peel, with the composition of the present invention for a sufficient period of time, and spooning for 15 to 5 minutes to reduce the amount of bacteria to a desirable level. The composition of the present invention It may be wiped or rinsed from the skin, or it may be left on the skin to evaporate the volatile components in the composition. The above and other new aspects and advantages of the present invention will be described in the non-limiting description of the preferred examples below Clarification. Examples of detailed personal care products, Do not be those who contain traditional active antibacterial agents, those who have been known for many years. Since the introduction of antibacterial personal care products, there have been many ^ -10- This paper is a fine Chinese national standard (CNS) A4 specification (210 X 297) )

546149 Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs

-------- 1 --------- (Please read the notes on the back before filling this page) H Λί < I I I I

A7 B7 V. Invention Description (8) All of them believe that their products can provide antibacterial properties. However, for an antibacterial composition to be the most effective, it must provide high logarithmic decay to the Guangfanyuan organism in the shortest possible contact time. As currently formulated, commercially available liquid antimicrobial package compositions can only be used to provide poor performance to marginal time killing efficiency, that is, sterilization rate. Table 丨 summarizes the killing efficiency of commercially available products I, each of which contains about 0.02 wt% to 0.33 wt% of 0.018 cents (i.e., a traditional antibacterial agent). Gram-positive bacteria to staphylococcus 1.39 2.20 1.85: Other related E. coli. Therefore, the present invention is related to the antibacterial group human makeup # U 异 ^ 机 囷, and compound which has :! a broad-spectrum antibacterial effect, which can be measured by the bacteria's fast i # ^ (that is, instant killing), magic … W _ 夬 Bao Yuren is not adept at killing continuously. / 、 Comparison of the first Λ general matter, this hair * 眭 轳 轳 ^ Poverty-stricken moon anti-composition composition provides excellent time only effect theory · The present inventor P1, human only, the effectiveness of population is amazing ,because,

The antibacterial efficacy and polyhydroxy group of the active antibacterial agent 囷 H I, which contains no active antibacterial agent or the horse's optional ingredients.

This paper is suitable for scale ® x 297 mm) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 546149 A7 ---------- B7 V. Description of the invention (9) of the agents, solubilizers and surfactants There is an association. In a preferred embodiment, the weight ratio of the solubilizer to the polyhydroxy solvent is from about 1: 1 to about 6: 1. In the case where the active antimicrobial agent is selected, the content of the agent when measured at room temperature is at least 2%, and preferably at least 25% saturation. With regard to the "% saturation" of the active biocide selected, it has been found that the antimicrobial efficacy of an active agent can be related to the speed at which the agent approaches the active site contained in the microorganism. The driving force that determines the speed at which the agent is delivered to the site of action is the difference in chemical potential between the site of action and the external aqueous phase. In other words, the microbicidal activity of an active agent is directly proportional to its thermodynamic activity in the external phase. Therefore, both thermodynamic activity and concentration are important variables regarding antimicrobial activity. As will be discussed more fully later, it is convenient to associate whitening and thermodynamic activity with the percent saturation of the active antibacterial agent in the continuous aqueous phase of the composition. The percent saturation of an active antibacterial agent in any composition, including a surfactant-containing composition, can theoretically be expressed as:% saturation = [C / Cs] x 100% where C refers to the antibacterial agent in The concentration in the composition and Cs refers to the saturated concentration of the antibacterial agent in the composition at room temperature. Once the percent saturation, or relative thermodynamic activity or relative chemical potential, of the antibacterial active agent dissolved in the surfactant-containing composition is the same, it is the same everywhere in the composition. Therefore, the terms "saturation" in the composition " in the composition ", " in the continuous aqueous phase of the composition " and " in the colloidal particle pseudophase of the composition " are interchangeable, and are disclosed throughout the article It is used in the same way. The difference in thermodynamic activity of the active antibacterial agent between the composition and the target tissue (please read the note on the back? Matters before filling this page)

I 1 n nMff I -12-

Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 546149 V. Description of the invention (10) The greatest difference (that is, when the composition is more saturated by the active ingredient), the maximum antibacterial effect is achieved. The second factor affecting the antibacterial activity is the total amount of active agents available in the composition, which can be considered as the 'critical dose'. Therefore, the two key factors of the antibacterial efficacy of the active agent in the composition are: (i = utilization rate, which is determined by its thermodynamic activity, that is,-in the fine compound = percentage in the water phase Saturation, and (2) the total amount of active agents available in the solution. ~ An important ingredient in the antibacterial cleaning composition is the surfactant, which can be used as a solubilizer, detergent and foaming agent. The surfactant affects the solution The percent saturation of the antibacterial agent in the medium, or more importantly, affects the percent saturation of the active agent in the continuous aqueous phase of the composition. This effect can be a water-insoluble antibacterial agent in which the active agent is distributed in the aqueous phase ( (Ie the continuous phase) and the pseudophase of the colloidal particles in the aqueous solution of the surfactant. The antibacterial agent with very low solubility in water, such as tricloxasan, has a stronger distribution than the colloidal particles (ie, A large amount of ㈣.san molecules will be present in the boundary particles, such as the opposite of the water phase.) The ratio of surfactant to antibacterial agent directly determines the content of the active agent in the surfactant gel particles, which in turn affects the active agent in continuous water One hundred in the phase Saturation. It has been found that when the ratio of the surfactant is increased, the number of colloidal particles relative to the living molecule also increases. As the ratio increases, the degree of saturation of the colloidal particles by the active agent decreases proportionally. In the continuous phase, the = agent and the active agent system in the colloidal particle pseudophase are in phase equilibrium, so when the saturation of the antibacterial agent in the colloidal particle phase is reduced, the antibacterial agent in the continuous phase will also be reduced. The reverse is also true. The activity after dissolving in the colloidal particles pseudo--13- (Please read the note on the back? Matters before filling out this page)

) 46149 A7 B7 V. Description of the invention (11 agents cannot be used to immediately saturate the active agent with the microorganisms: ：: At this time, the antibacterial activity of the composition is determined by the saturation of the white blade in the continuous aqueous phase. However, The active agent in the interfacial colloidal particles can be used as a storage place for the active agent and supplemented when the active agent in the continuous aqueous phase is depleted. ^ An antibacterial composition phaser who previously relied on a traditional active antibacterial agent to produce efficacy 'The invention The composition and the antibacterial agent that do not depend on them are equal to the hair and medium as an optional ingredient. The composition of the present invention relies on a combination of polyamines, and it is preferable that the solubilizing agent and polyhydric solvent The ratio is about 1: 1 to about 6: 1. If it is contained, the selected antibacterial agent is measured at room temperature to obtain a content of at least 2% saturation. According to the present invention, the heart substance has improved resistance to Gram-negative bacteria and An antibacterial composition having gram-positive bacteria efficacy and exhibiting rapid bacterial killing. As illustrated in the following specific examples, the antibacterial composition of the present invention includes: more than about 1% to about 50% by weight Recording solvent; ⑻ ^ weight To about 50% by weight of solubilizer; (0 to about 0 to about 25% by weight of a surfactant; (d) 0% to about 5% by weight of an antibacterial agent; and (the line water. The interfacial activity The preferred agent is an anionic surfactant. However, the nature of the surfactant is not limiting, especially when the weight ratio of the agent to the polyhydroxy solvent is from about 1: 1 to about 6: 1, and The best is about 5q to about 5: 1. If the composition contains an active antibacterial agent, the composition of the present invention has at least about 2% of the measured value at room temperature, and preferably at least about Jona ’s antibacterial agent. Percent saturation in the continuous aqueous phase. The composition of the present invention exhibits a logarithmic decay of Gram-positive bacteria of about 2 after 30 seconds of contact. The present invention is -14- This paper is scaled to the Chinese National Standard (CNS ) A4 size (210 X 297 Public Love 546149 Printed by A7 B7____ of the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs V. Description of the invention (12) The compound exhibited a logarithmic decay of Gram-negative bacteria of about 2.5 after 30 seconds of contact The content of the polyhydroxy solvent and the multi-based solvent in the antibacterial composition is About 1% to about 50% by weight of the composition, preferably about 5% to about 25%. To achieve the full advantages of the present invention, the content of the polyhydroxy solvent is about 5% to about 15% by weight of the composition. As used herein, the term "polyhydric solvent" is a water-soluble organic compound containing 2 to 6, typically 2 or 3 radicals. The term "water-soluble" refers to the multi-based solvent at 25. : Has a water solubility of at least 0.1 g of a polyhydric solvent per 100 g of water. There is no upper limit for the water solubility of a polyhydric solvent, that is, 'Evening-based solvents can dissolve in water in any proportion. Therefore, "· Polyhydroxy solvents, including water-soluble diols, triols, and polyols. Specific examples of each base include, but are not limited to, ethylene glycol, propylene glycol, glycerol, diethylene glycol, dipropylene glycol, tripropylene glycol, and hexane. Diol, Ig, 3 · butanediol '14-butanediol, 1,2,6 · hexanetriol, sorbitol, peG-4' PEG-6, and similar polyols. Solubilizer In addition to the polyhydroxy solvent, the antibacterial composition of the present invention contains a solubilizer. The content of the solubilizer is as high as the solubility of the solubilizer in 2 μC of water, which typically ranges from about 1% to about 50% by weight of the composition, preferably from about 5% to about 30%. To achieve the full advantages of the present invention, the solubilizer is present at a level of from about 10% to about 30% by weight of the composition. Swelling agents are compounds that increase the water solubility of other compounds. Solubilization -15- This paper size applies to China National Standard (CNS) A4 specifications (21Q x 297 male shame), -------------------- Order ---- ----- Line— ▲ (Please read the precautions on the back before filling out this page) 546149 A7, Description of Invention (13) It lacks the characteristics of surfactant and is typically a short-chain alkyl aryl sulfonic acid :. Specific examples of enhancers include, but are not limited to, * sodium propene benzene sulfonate, ^, propionate, ammonium xylate, ammonium toluene acid, sodium toluene acid, toluene acid, toluene sulfonic acid, and Xylene sulfonic acid. Other usable solubilizers include polysuccinic acid steel, polyphenylene succinic acid, methyl succinic acid steel and disodium succinate. • In a preferred embodiment of the present invention, the weight ratio of the solubilizer to the polyhydroxy solvent is: 1 to, 々6,1 ', preferably about 1.5: 1 to about 5: 1. To achieve the advantages of the present invention, the ratio of solubilizer to polyhydric solvent is from about 2: 1 to about 4: 1. When the weight ratio of the mixture to the solvent per base is more than 2, the nature of the surfactant is not affected by PM,]. When the weight ratio of the solubilizer to the multi-base solvent is different, the preferred surfactant is an anionic surfactant. Interfacial activity i As mentioned above, in addition to the polyhydroxy solvent and the solubilizing agent, the anti-microbiological composition of the present invention also contains a surfactant. The content of the surfactant is from 1% by weight to about 25% by weight, preferably from about 2% by weight to about 20% by weight. Horses achieve the full advantage of the present invention, and the antibacterial composition contains from about 2% to about 5% by weight of a surfactant. Ready-to-use compositions typically contain the composition from about i% by weight to about i0 weight% / 〇, preferably about 1.5 weight% / ❶ to about 5 weight%, and most preferably about j 5 weight% /. Surfactant to 3, 0, 0 scoop. Concentrated compositions suitable for dilution typically contain greater than about 5% by weight of a surfactant. In a preferred embodiment, the amount of surfactant is determined such that, if contained, the percent saturation of the antibacterial agent selected in the continuous aqueous phase of the composition (please read the precautions on the back before filling this page) ) · Line · Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs-16- 546149 Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs A7 B7 V. Description of the invention (14) is at least about 2%, preferably at least about 25% And the best is at least about 50%. The nature of the surfactant is not limited. In particular, when the weight ratio of the solubilizer to the polyhydroxyl cereal is about 1: i to about 6: 1, the surfactant may be an anionic surfactant, a cationic surfactant, a nonionic surfactant or an interface. A compatible mixture of active agents. Within their weight ratios, the surfactant can also be an ampholytic surfactant that is cationic in an acidic solution and anionic in an alkaline solution, or has opposite ends. The charge is an amphoteric surfactant that exhibits acidic or basic properties according to pΗ 値 of the composition. In addition to this ratio, preferred surfactants are anionic surfactants. Therefore, the antibacterial composition preferably contains an anionic surfactant with a hydrophobic moiety, such as a carbon containing about 8 to about 30 carbon atoms, and in particular a carbon containing about 12 to about 20 carbon atoms. Chain, and more with a hydrophilic moiety, such as sulfate, sulfonate, carbonate, phosphate, or carboxylate. The hydrophobic carbon chain is often etherified, such as with ethylene oxide or propylene oxide, to impart special physical properties, such as increasing water solubility or reducing the surface tension of the anionic surfactant. Accordingly, suitable anionic surfactants include, but are not limited to, the following known classes of compounds: such as alkyl sulfates, alkyl ether sulfates, alkyl ether sulfonates, alkylphenoxy polyoxyethylene ethanol sulfates , From-olefin sulfonate, lu-alkoxyalkane sulfonate, alkylaryl sulfonate, alkyl glycerol monosulfate, alkyl glycerol monosulfonate, alkyl carbonate, alkyl ether carboxylate Acid salt, fatty acid, sulfosuccinate, sarcosinate, octyl alcohol or non-17- This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) ----- --- Order --------- line- ▲ (Please read the notes on the back before filling out this page) 546149 Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs A7 ------- B7 5 2. Description of the invention (15) Oxyalcohol phosphate, taurate, fatty taurate, fatty acid amidopolyoxyethylene sulfate, triacetylacetate, or mixtures thereof. Other anionic surfactants are listed in McCutcheon, s Emulsifiers and Detergents, 1993 Annuals, (hereinafter referred to as McCutcheon, s), McCutcheon Division, MC Publishing Co.? Glen Rock, NJ? Pp. 263-266 ' It is incorporated herein by reference. Many other anionic surfactants, and classes of anionic surfactants, are also disclosed in Laughlin & U.S. Patent No. 3,929,678, which is incorporated herein by reference. Particularly preferred anionic surfactants contain no more than 2 moles of ethoxy and can be selected from the following surfactant categories: ^ / alkyl sulfate, 6 < 18 fatty acid salt, i or 2 ethyl Oxy. / With alkyl ether sulfate, CVCu ammonium oxide, CfCi8 burned sarcosinate, C8_Cu acetic acid acetate 'Cs-Cu continuous acid succinate, Cs-Cu fluorinated diphenyl ether Izaki So @ -salt, Cs-Cu fluorinated carbonic acid g, 晞 alkane dicarboxylic acid, sulfonium salt, sulfonic acid methyl ester salt, and mixtures thereof. C8_Ci8 alkyl includes 8 to 16 carbon atoms and can be straight chain (eg, lauryl) or branched chain (eg, 2-ethylhexyl). The cation of the anionic surfactant can be an alkali metal (preferably sodium or potassium), ammonium, Cl-C4 alkylammonium (mono, bis-, tri_), or C1-C3 alkanolammonium (mono_, bis_ ,three_). Lithium and alkaline earth cations (= eg, magnesium) are available, but the antibacterial effect is reduced. Particularly preferred anionic surfactants include, but are not limited to, lauryl sulfate, octyl sulfate, octaethylhexyl sulfate, laurylamine oxide, decyl sulfate, and tridecyl sulfate. Purpose salt, coconut salt, lauryl sarcosinate, lauryl sulfosuccinate salt, linear C one (Please read the note on the back? Matters before filling out this page)

Order --------- line—I -18-

546149

V. Description of the invention (16) (Please read the notes on the back before filling this page)

Disulfonic acid vinegar salt, lauryl sulfosuccinate salt, lauryl ether sulfate (1 and 2 mole ethylene oxide), myristyl sulfate, oleate 'stearate' Taurate, ricinoleate, cetyl sulfate, and similar surfactants. Other examples of surfactants are found in CTFA

Cosmetic Ingredient Handbook " J.M. Nikitakis, ed. The

Cosmetic, Toiletry and Fragrance Association, Inc., Washington, DC (1988) (hereinafter CTFA Handbok), pages 1 (M3, 42-46, and 87.94), which are incorporated herein by reference. The antibacterial composition is also Non-ionic surfactants may be included. Typically, non-ionic surfactants contain a hydrophobic group, such as a long-chain alkyl or alkylated aromatic group, and a hydrophilic chain containing a sufficient number (ie, 1 to About 30%) of ethoxy and / or propoxy moieties. Examples of classes of non-ionic surfactants include ethoxylated phenols, ethoxylated and propoxylated fatty alcohols, polyethylene glycol ethers of methyl glucose ' Polyethylene glycol ethers of sorbitol, ethoxylated esters of fatty (C8_cls) acids of ethylene oxide · propylene oxide segment copolymers, condensation products of ethylene oxide with long-chain amines or fluorene amines, and mixtures thereof Examples of non-ionic surfactants printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs include, but are not limited to, methyl gluceth-10, PEG-20 methyl glucose distearate, pEG 20 methyl glucose. Semistearate, (311_15 卩 & Generation 1: 11_20, 〇616 化 -8, 〇616111-12, dodoxyn〇l-12, laureth_15, PEG-20 million sesame oil, p_ly_ sorbate 20, steareth-20, polyethylene oxide_ 1 cetyl ether, polyoxidation Ethylene-10 stearyl ether, polyoxyethylene-2 cetearyl ether, polyoxyethylene-10 oleyl ether, polyoxyethylene-2 oleyl ether, ethoxylated nonylphenol, or ethoxylated octylphenol , Ethoxylated dodecyl phenol, or ethoxylated fat (c6_c ^) -19- This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs 546149 A7 B7 V. Description of the invention (17) Alcohol, including 3 to 20 ethylene oxide moieties, polyoxyethylene-20 isohexadecyl ether, polyoxyethylene-2 3 glyceryl laurate, polyoxyethylene- 2 0 glyceryl stearate, PPG-10 methyl glucosyl ether, PPG-20 methyl glucosyl ether, polyoxyethylene-2 0 sorbitol monoester, polyoxyethylene-8 0 castor oil, polyethylene oxide- 1 5 tridecyl ether, polyethylene oxide-6 tridecanthyl ether, laureth-2, laureth-3, laureth-4, PEG-3 castor oil, PEG 600 dioleic acid , PEG 400 dioleate, and mixtures thereof. Many other nonionic surfactants are contained in McCutcheon, Detergents and Emulsifiers, 1993 Annuals, published by McCutcheon Division, MC Publishing Co., Glen Rock, NJ, pp. 1- 246 and 266-272; in the CTFA International Cosmetic Ingredient Dictionary, Fourth Ed.? Cosmetic, Toiletry and Fragrance Association, Washington, DC (1991) (hereinafter CTFA Dictionary) pages 1-651; and CTFA Handbook, pages 86-94 It is incorporated herein by reference. In addition to anionic and nonionic surfactants, cationic, amphiphilic and amphoteric surfactants can be used in antimicrobial compositions. Cationic surfactants include amine oxides and amidoamine oxides, such as cocoamine oxide, decylamine oxide, and myristylamine oxide. Amphiphilic surfactants can be broadly described as derivatives of second and third amines containing linear or branched aliphatic groups, and one of the aromatic substituents contains about 8 to 18 carbon atoms and At least one aliphatic substituent includes an anionic water-soluble group, such as a carboxyl group, a sulfonate group, or a sulfate group. It is stated here that -20- This paper size applies to the Chinese National Standard (CNS) A4 (210 X 297 mm)-I! — — — — — — — — — II-I · 1111-— II I ---- ---- i ---_ i ----- — I —-- (Please read the notes on the back before filling out this page) 546149 A7 ----- ____B7_______ V. Examples of compounds in the description of the invention (18) 3 · (dodecylamino) sodium propionate, 3- (dodecylamino) propanone-1-acetate sodium, 2- (dodecylamino) ethyl sulfate, 2 · (di Methylamino) sodium octadecanoate, 3- (N-carboxymethyl-dodecylamino) propane disodium sulfonate, disodium octadecylimodiacetate, i_lean methyl _2_Undecylammonium sodium, and team: ^ _bis (2-hydroxyethyl) · fluorene sulfate-3_dodecyloxypropylamine. More specifically, there is a class of amphiphilic surfactants including sarcosinates and taurates with the general structure shown below. Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economy on

Me-1 R

-2 IN- R

CH Y-η wherein R1 is a Cn to C21 alkyl group, R2 is hydrogen or CVC2 alkyl group, Y is CO2M or S03M, M is an alkali metal, and η is a number from 1 to 3. Another class of ionic surfactants are amidosulfonic acid succinates with the structural formula shown below. 〇s〇3Wα II I R1-NHCCH2-CH-C02'Na4 · The following types of ionic surfactants can also be used. : CH2C02'Na ^

CH2CH2〇H alkoamphoglycinates -21-This paper size applies to China National Standard (CNS) A4 (210 X 297 mm), -------- Order --------- Line 丨 Win (Please Read the notes on the back before filling this page) 546149 A7 B7 V. Description of the invention (19) 〇CH2C〇2-Na + R ^ CNH CH2CH2jiCH2C〇2H ch2ch2oh alkoamphocarboxyglycinates 0Jl I r1cnhch2ch2n CH2CH2C02'Na ^ (Please read the notes on the back first (Please fill out this page again). ¾

CH2CH2OH-alkoamphopropionates 〇 CH2CH2C02 * Na ^

R1CNHCH2CH2NCH2C〇2H ch2ch2〇h alkoamphocarboxypropionates Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs

OH 〇 CH2CHCH2S03-Na ^

I r1cnhch2ch2n ch2ch2〇h alkoamphopropylsulfonates -22- This paper size applies to Chinese National Standard (CNS) A4 (210 X 297 mm) 546149 A7 _B7_ V. Description of the invention (20) o ch3Jl I R1CNH (CH2) 3N " -CH2C02 -ch3 alkamidopropyl betaines Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs

H N o = c 1 R 3 H c,

CH • N—c 3 o s 2 H c Η H 〇——c 2 H c

3 H alkamidopropyl hydroxysultaine 〇 R1NHCH2CH2C-0'Na > alkylaminopropionates CH2CH2C〇2 * I RNH I ch2ch2c〇2h alkyliminopropionates. -23- (Please read the notes on the back before filling this page)

This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) 546149 A7 B7 V. Description of the invention (21) Other types of ionic surfactants include phosphobetaines and phosphinees 〇 (Please read the note on the back first Please fill in this page again.) Special non-limiting examples of ionic surfactants that can be used in the present invention printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs are coconut N-methyl sodium taurine and oil-based N-formaldehyde. Sodium taurate, sodium N-methyltaurate peroleate, sodium palmitate N-methyltaurine, coconut dimethylcarboxymethylhydantoin, lauryldimethylcarboxymethyl Betaine salts, Lauryl dimethyl carboxyethyl betaine, cetyl dimethyl carboxymethyl betaine, lauryl-bis- (2-hydroxyethyl) carboxymethyl betaine Salt, oleyldimethyl-r-carboxypropylhydantoin, lauryl-bis- (2-hydroxyethyl) carboxyethylhydantoin Salt 'stearin amine dimethyl propyl continued salt, laurel amine-bis- (2-triylethyl) propyl hormonal salt, oleylamine PEG-2 sulfonate Disodium succinate, TEA salt of oleylamine PEG-2 sulfosuccinic acid, disodium oleamide MIPA sulfosuccinic acid succinate, sesameamine ME A disodium sulfosuccinate, eleven Disenamine ME A disodium succinate, wheat germamine ME A disodium succinate, wheat germamine PEG-2 disodium succinate, isostearylamine MEA disodium succinate, sesameamine MEA disodium succinate, cocoamphoglycinate, cocoamphocarboxyglycinate, laurel bisexual Glycine, Laurel Amphoteric Carboxyglycinate, Decayer Amphoteric Carboxylglymate, Coconut Amphoteric Amphoterate, Coconut Amphoteric Amphoterate Carboxylate, Laurel Amphoterium Amphoteric Carboxypropionate, Decanter Amphoteric Carboxyl Propionate, dihydroxyethyl tallow glycinate, cocoamine disodium 3-hydroxypropyl betaine, disodium, lauronium myristate amino 3-hydroxypropyl betaine, lauryl Pyridyl myristate Pyridamine-24- This paper size applies to Chinese National Standard (CNS) A4 (210 X 297 mm) 546149 Ministry of Economic Affairs A7 printed by the Bureau ’s Consumer Cooperative. V. Description of the invention (22) glyceryl glyceryl phosphate, ammonium myristyl ammonium carboxyl disodium 3-hydroxypropyl phosphate, ammonium propyl Monosodium phosphite salt, laurylamine myristylaminopropyl sodium monosodium phosphite, and their mixtures. Carrier The carrier of the antibacterial composition of the present invention includes water. Optional ingredients. The antibacterial composition of the present invention may also include optional ingredients well known to those skilled in the art. For example, the composition of the invention may comprise an active antibacterial agent or an alcohol. These particular optional ingredients and their content in the composition will be discussed later. The composition of the present invention may also contain other optional ingredients such as dyes and fragrances, which contain I enough to highlight its intended function without adversely affecting the antibacterial efficacy of the composition of the present invention. The individual content of their selected ingredients is typically from 0% by weight to about 5% by weight of the compound. / ❶, and the total is from 0% to about 20% by weight of the composition.

The types of ingredients used include, but are not limited to, dyes, fragrances, pH withers, thickeners, viscosity modifiers, buffers, foam stabilizers, antioxidants, skin conditioners and protectants, foam enhancers, Chelating agents, gelling agents, cloth clearing agents, vitamins, and similar optional ingredients are well known to those skilled in the art. Specific categories of ingredients selected include alkanolamines as foam enhancers and stabilizers, gums and polymers as thickeners; vitamins A 'E and C as vitamins; inorganic phosphates, sulfates and Carbonic acid-25- This paper is in accordance with China National Standard (CNS) A4 specification (21q χ 297 public love) __ (Please read the note on the back? Matters before filling this page)

546149

V. Description of the invention (23) Salts, polyamine acids and salts as chelating agents, such as EDTA and phosphate; and acids and bases as regulators of pp. Examples of preferred alkaline pH regulators are ammonia; mono-, bis-, and tri-alkylamines, mono-, bis-, and di-alkanolamines; hydroxides of metal and earth metals; and Its mixture. However, the nature of this basic pH regulator is not limited 'and any basic pH regulator known in the art can be used. Specific non-limiting examples of basic pH adjusters are ammonia; hydroxides of sodium, potassium, and lithium; monoethanolamine, triethylamine; isopropanolamine; diethanolamine; and triethanolamine. Examples of preferred categories of acidic pH regulators are mineral acids and polycarboxylic acids. Non-limiting examples of mineral acids are hydrochloric acid, nitric acid, osmic acid, and sulfuric acid. Non-limiting examples of polycarboxylic acids are citric acid, glycolic acid, and lactic acid. The nature of the acidic pH adjuster is not limited and any acidic pH adjuster 'known in the art can be used alone or in combination. The alkanolamide that provides composition viscosity, foam enhancement, and foam stability may be, but is not limited to, cocoamine MEa, cocoamine DEA, soyamine DEA, lauramine DEA, oleamide MIPA, hard Lipidamine MEA, myristylamine MEA, laurylamine MEA, decylamine DEA, melamine DEA, myristylamine DEA, stearylamine DEA, oleylamine DEA, tallowamine DEA, Laurylamine MIP A, tallowamine ME A, isostearylamine d EA, isostearylamine ME A, and mixtures thereof. Selected antibacterial agent The content of the selected active antibacterial agent in the composition of the present invention is 0-26 of the composition. This paper size is applicable to the Chinese National Standard (CNS) A4 specification (210 X 297 mm) (please read the note on the back first) Please fill in this page for further information) -Line · Printed by the Employees 'Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs Printed by the Employees' Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 546149 A7

5. Description of the invention (24) The weight / 0 to 5 weight%, and preferably about 0.001% to about 3% by weight. To achieve the full advantages of the present invention, this antibacterial agent is present in an amount of from about 0.01% to about 1% by weight of the composition. The antibacterial composition may be a ready-to-use composition, which typically contains 0 to about 2 weight ❶ / ❶, preferably 0.001 to about 5 weight =, and most preferably About 0.05% by weight of the antibacterial agent. This antibacterial composition can also be formulated as a concentrate, which can be diluted with about ^ to 100 parts of water before use to make an end-use composition. This concentrated composition typically contains 0 weight. / ❶ to about 0% by weight of the antibacterial agent. This application also envisions that the end-use composition contains more than 2% by weight of an antibacterial agent. The content of the antibacterial agent in the composition of the present invention, when it is contained in the right final%, may be at least about 2 wt.%, And preferably at least about 25 wt.%, Of the saturated concentration of the antibacterial agent in water when measured at room temperature. . To achieve the full advantage of the present invention, the 'continuous aqueous phase system is saturated with about 50Q /. To 100Q / ❶ antibacterial agent. The content of antibacterial agent in the continuous aqueous phase can be defined as the total amount of antibacterial agent in the composition minus any amount of antibacterial agent in the surfactant gel particles. The method for determining the percent saturation of the antibacterial agent in the composition is disclosed below. Antibacterial agents that can be used in the present invention are phenolic compounds such as the following classes of compounds; (a) 2-hydroxydiphenyl compounds

-27- This paper size is applicable to China National Standard (CNS) A4 (21G X 297 public love) (Please read the note on the back first? Matters before filling out this page)

546149 A7 B7 V. Description of the invention (25) where Y is chlorine or bromine, Z is SO2H'NO2 'or (^ -04), r is 0 to 3, 0 is 0 to 3, and ρ is 0 or 1, m Is 0 or 1, and η is 0 or 1. In a preferred embodiment, rhenium is chlorine or bromine, m is 0, η is 0 or 1, 0 is 1 or 2, r is 1 or 2, and ρ is 0. In a particularly preferred embodiment, Y is chlorine, m is 0, η is 0, 0 is 1, r is 2, and ρ is 0. A particularly useful 2-hydroxydiphenyl compound has the structure shown below: C1 OH Cl has a well-known name, triclosan, which is marketed under the trade name IRGASAN DP100 and is provided by Ciba Specialty Chemicals Corp. Greensboro, NC. Another useful 2- phenyl diphenyl compound is 2,2 ' -Dihydroxy-5,5 · -dibromo-diphenyl ether. (B) Analytical derivatives (Please read the precautions on the back before filling this page) -------- Order · --I- --I 1 ^ Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs

0H

Wherein Ri is hydrogen, via radical, Ci-CU radical, gas radical, nitrate radical, phenyl radical, or hexyl radical; R2 is hydrogen, # is radical, Ci-C6 radical, or halogen radical; Hydrogen 'Ci_C6 alkyl, hydroxy, gas-based, nitro or -28 in the form of alkali metal salt or ammonium salt-This paper size is applicable to Chinese National Standard (CNS) A4 specification (210 X 297 mm) 546149 V. Invention Note (26) Sulfur; R4 is hydrogen or methyl and R @ 々K5 horse wind or nitro. Halo is bromo or, preferably, gas. Specific examples of fluorene derivatives & k. Fu Jiongyu includes, but is not limited to, chlorophenols (o-, m-, p-), 2,4-dichlorophenol, p-nitrophenol, picric acid, Dimethylphenol, p-chloro-m-dimethylphenol, cresol (o-, m-, p-), p-chloro-m-methyl ', pyrocatechol, resorcinol, heart N-hexyl resorcinol, pyrogallic acid, m-trisorcinol, carvacrol, vanillin, p-chlorovanillin, o-phenylphenol, o-uryl, p-chloro_o- · Benzyl dihydroxanthol, tetrabenzyl, 4-ethylpananyl, and 4-benzene dibasic acid. Other phenol derivatives are listed in WO 98/55096, which is incorporated herein by reference. (c) Diphenyl compounds (Please read the note on the back? Matters before filling out this page)

R3 _ Line · Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs where X is sulfur or methylene, R1 and hydroxy, and R2, r, 2, R3, m '' r'4, r5 and r'5, These are independently hydrogen or halo. Particularly non-limiting examples of diphenyl compounds are hexachlorophene, tetrachlorophene, dichlorophene, 2,3_dihydroxy-3,3,5,5, -tetrachloro Phenyl sulfide, 2,2, -dihydroxy-3,5 ·, 5,5 ', 6,6, -hexachlorophenylsulfide and 3,3f-dibromo-5,5, · digas-2, 2, -dihydroxydiphenylamine. Other diphenyl compounds are listed in WO 98/55096, which is incorporated herein by reference. 29-This paper size is in accordance with Chinese National Standard (CNS) A4 (210 X 297 mm) 546149 A7 Five invention instructions (27 Selection of alcohol (please read the note on the back? Matters before filling this page) Antibacterial composition of the present invention Optionally, it may also contain 0% to about 20% by weight of alcohol. Preferred examples include 0% to about 15% by weight of alcohol, and best examples contain 0% to about 10% by weight of disinfectant alcohol. As defined herein, the term " alcohol " is defined as a water-soluble alcohol containing from 1 to 6 carbon atoms. Suitable alcohols include, but are not limited to, methanol, ethanol, propanol, and isopropanol. Alcohol Can be used as a carrier with water. Alcohol can also make the antibacterial composition have disinfection properties. The gelling agent selected-thread-This antibacterial composition can also contain 0% to about 5%, preferably 0% to About 3% by weight of gelling agent. To achieve the full advantages of the present invention, this antibacterial composition contains about 0% to about 25% by weight of gelling agent. The antibacterial composition typically contains a sufficient amount of selected gelling agent to make the combination Things become sticky liquids, gels or Solid for easy application and rubbing on the skin. Those skilled in the art know the type and amount of gelling agent used in the composition to make the composition have the desired composition viscosity or silk density. The term "gelling agent" printed by the Property Cooperative Consumer Cooperative, as used herein and below, refers to a compound that can increase the viscosity of an aqueous composition or convert an aqueous composition into a gel or semi-solid. Therefore, The gelling agent may be of organic nature, such as natural gums or synthetic polymers, or of inorganic nature. Preferred gelling agents are natural or synthetic polymers or derivatives of natural polymers (eg, polyacrylic acid Grease, cellulose resin), such as carbomers, polyqUaterniums, and carboxymethyl cellulose (e.g., METHOCEL (R) products, available from Dow Chemical -30- This paper size applies to Chinese National Standard (CNS) A4 specifications (21G X 297 (Mm) 546149 A7 B7 V. Description of the invention (28)

Co., Midland, MI) 〇 skin conditioner and protector (please read the note on the back? Matters before filling out this page) printed by the Consumers ’Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs, the antibacterial composition of the present invention may also contain optional Skin conditioner and / or protective agent. Examples of skin conditioners include emollients, such as cetyl myristate, glyceryl dioleate, isopropyl myristate, cotton tallow, methyl laurate, PPG- September Laurate, Soy Stearate, Octyl Palmitate, and PPG-5 Lanolinate. The skin conditioner may also be a humectant, such as glucosamine and pyridoxine. Absorptive skin conditioners such as aluminum lanate, corn oil, methylone, coconut oil, stearyl stearate, trimethylol, triglyceride Trimyristin, olive oil and synthetic waxes can also be used. In addition to the complex skin conditioning agents known to those skilled in the art, a combination of multiple types of skin conditioning agents can be used alone or in combination. Non-limiting examples of heterodermal skin conditioners include aloe vera, cholesterol, cystine, keratin, lecithin, egg yolk, glycine, PPG-12, vitamin A, salicylic acid, orotic acid, vegetable oil, and soluble animal collagen. Skin conditioners can be used alone or in combination with skin protection agents such as petroleum, cocoa beans, calamine, and kaolin. Skin protectants can also be used alone. Other examples of skin conditioners and protective agents can be found in " CTFA Cosmetic Ingredient Handbook'1 JM Nikitakis, ed., The Cosmetic, Toiletry and Fragrance Association, Inc.? Washington, DC, (1988) (hereinafter CTFA Handbook), pages 79-85, which are incorporated herein by reference. The antibacterial composition of the present invention does not rely on low or high p Η 値 to make the flora fast -31-This paper size applies Chinese National Standard (CNS) A4 specification (21 × X 297 mm) 546149 A7 B7 V. Description of the invention (29) (Please read the Zhuyin on the back? Matters before filling out this page) The antibacterial composition of the present invention may have a p Η 値 of about 4 to about 9, but at both ends of this ρ Η range, the composition of the present invention may cause irritation to the skin or damage other surfaces in contact with the composition of the present invention. Accordingly, the antibacterial composition of the present invention preferably has a ρ 値 约 of about 5 to about 8, and more preferably about 6 to 8. To achieve the full advantage of the present invention, the antibacterial composition has a pH of about 6.5 to about 7.5. In order to prove the new and unexpected results provided by the antibacterial composition of the present invention, the following examples and comparative examples were prepared and the ability of the composition of the present invention to control Gram-positive bacteria and Gram-negative bacteria was measured. The weight percentages listed in the following examples are the actual or active weights of the various ingredients contained in the composition. The composition of the present invention is prepared by blending various ingredients, as known to those skilled in the art and described below. The following substances were used as the components of the examples. The sources of various ingredients and their abbreviations are summarized as follows: a) Carbopolyglucosamine (APG), Henkel Corp., Hoboken, NJ, PLANTAREN 2000N UP (ϋ = 55.53%) ^ b) ammonium lauryl sulfate (ALS), Henkel Corp., ST AND APOL A (activity level = 2 8.3%), printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs c) ammonium xylene sulfonate (AXS), Stepan Corp ·, STEP ANATE AXS (activity = 40% ), D) Cocamidopropyl betaine (C APB), McIntyre Group, Ltd., Chicago, IL, MACKAM 35-HP (estimated 30% active betaine salt), e) dipropylene glycol ( DPG), Dow Chemical Co., Midland, Ml, -32- This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) 546149 A7 B7 V. Description of the invention (30) f) Isopropanol ( IP A), g) monoethanolamine lauryl sulfate (MEALS), Albright & Wilson, Cumbria, England, EMPICOL LQ 33 / F (activity = 33%), h) octylphenol ethoxylate, 9-10 Mo Ear EO (TX100), Union Carbide, TRITON-X 100, i) Potassium cocoate (KCO), McIntyre Group, Ltd., MACKADET 40- K (activity = 38.4%), j) potassium laurate (KL), prepared from lauric acid (Sigma, # L-4250, activity = 99.8%) and potassium hydroxide, k) oleic acid bell (KO) , Norman, Fox & Co, Vernon, CA, NORFOX KO (activity = about 80%), l) propylene glycol (PG), DOW Chemical Co., USP Grade (activity = 99.96%), m) coconut amphoteric acetic acid Sodium (SC A), McIntyre Group, Ltd., MACKAM IC-90 (activity = approximately 32%), n) Sodium cumene (SCS), Stepan Chemical Co ·, STEPANATE SCS (activity = 44.6% ), O) sodium lauryl ether sulfate, 1 mole EO (SLES-1), Henkel, STAND APOLES-1 (activity = 25.40%), p) sodium lauryl ether sulfate, 2 mole EO (SLES- 2), Henkel, STANDAPOLES-2 (activity = 25.71%), q) sodium lauryl ether sulfate / dodecyl sulfate (SLS / SDS), BDH Biochemical, BDH Ltd., Poole, England, (activity Degree = -33- i Paper size applies to Chinese National Standard (CNS) A4 (210 x 297 mm) (Please read the phonetic on the back? Please fill in this page for the matter) Order --------- Line · Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 546149 A7 B7 V. Invention Description (31) 99.0%) 9 (Please read the Note 2 on the back first Please fill in this page for further information) r) Sodium octyl sulfate (SOS), Henkel, STANDAPOL LF (activity = 32.90%), s) Sodium xylene xanthate (SXS), Stepan Chemical Co ”STEP ANATE SXS (activity = 40-42%), t) Triclosan (TCS), IRGASAN DP-300, Ciba Specialty Chemicals Corp., Greensboro, NC (GC verification of the batch used = 99.8-99.9% active TCS; mp = 56.0-58.0 C ), U) Triethanolamine lauryl sulfate (TEALS), Henkel, ST AND APOL T (activity = 40.1%), v) p-Chloro-m-xylenol (PCMX), NIPACIDE PX-R, Nipa INC · , Wilmington, Delaware (approximately 100% activity), and w) Water-distilled water or deionized water. The following methods were used in the preparation and testing of the examples: Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economy a) Determination of the rapid bactericidal (timed sterilization) activity of antibacterial products. The activity of the antibacterial composition is measured by the timed sterilization method Therefore, the survival rate of the challenged organisms exposed to the antibacterial test composition with respect to time is determined. In this test, a diluted liquid composition is contacted with a known number of test bacteria at a specific temperature for a specified period of time. After the end of this period, neutralize the test composition, which blocks the antibacterial activity of the composition. Calculate the percentage decay 値 or log decay 値 from the original flora. Generally speaking, the time sterilization method is used for Those skilled in the art know. The composition of the present invention can be tested at any concentration between 0 and 100%. The choice of concentration is based on the judgment of the researcher, and the appropriate concentration can be determined by the skilled person. National Standard (CNS) A4 specification (210 X 297 mm) '' Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 5. Description of the invention (32) 2 ^. For example, viscous samples are often diluted with 鄕 to thicken blood samples. Detergent, top ... From Yang Xiaoguan WO ml A strain is placed in a liter equipped with a magnetic stir bar ", and in a Christmas cup, if necessary, adjust the volume of # u to 100% with sterile deionized water. True Λ, 〇F factory 78 Book sample w 00 gross liters. All tests were performed in triplicate, and their results were combined and reported as the average log attenuation 値. The choice of exposure time also lies in the judgement of the researcher. Any contact time can be selected. Typical contact time is from 15 seconds to 5 minutes, and 3 = minutes = typical contact time. The contact temperature can also be any temperature, typically room temperature, or about 25 degrees Celsius. Bacterium suspensions, or test strains are prepared by culturing bacteria on any suitable solid selection medium (such as agar). The colonies were then washed from the above with sterile water I and the colonies of the bacterial suspension were adjusted to approximately 108 colony forming units per milliliter (cfu / ml). The following table lists the test bacteria used in the following tests and includes the names of the bacteria, the identification number of ATCC (American Type Culture collection), and the abbreviations of the organisms used later. Microbial name ATCC # write_ Staphylococcus aureus 6538 S. aureus Escherichia coli 11229 E. coli Klebsiella pneumoniae 10031 K. pneum. Salmonella choleraesuis) 10708 --------- S. choler. Staphylococcus aureus-Gram-positive bacteria, while E. coli, pneumoniae-35- This paper size applies to Chinese National Standard (CNS) A4 Specifications (210 X 297 mm) 546149 A7 V. Description of the invention (33) R. brevis and Salmonella choleraes are Gram-negative bacteria. Burnouts containing the test composition are placed in a water bath or at a magnetic stirrer (if the temperature in the surrounding laboratory is appropriate). This sample was then inoculated with 10 ml of a test bacterial suspension. The strain and the test composition are mixed and stirred for a predetermined contact time. When the contact time has expired, 1.0 ml of the test composition / bacterial mixture is transferred to a 9.0 penl Tryptone-Histidine-Tween neutralizer solution (THT). Ten-fold dilutions were then applied to the countable range. This dilution rate can vary from organism to organism. Triplicate on TSA + plate (TSA + for lecithin and

Polysorbate 80 Trypticase Soy Agar). The plates were then immersed in temperature for 25 ± 2 hours, and the number of remaining colonies was calculated and the percent attenuation 値 or logarithmic decay 値 was calculated. The control count (numerical control) was determined by substituting the test composition with TZO for the procedure described above. Digital control and sample plate counts of samples were converted to cfu / ml using standard microbiology methods. Calculate the logarithmic decay using the following formula: logarithmic decay: = 10 glQ (numerical control) _ 10 ◦ ◦ (test sample residual 値) The following table associates the percentage attenuation 菌 of the flora with 〇〇g attenuation: (Please (Read the precautions on the back before filling this page) -Line · Printed by the Intellectual Property Bureau of the Ministry of Economic Affairs, the employee's cooperative prints the% attenuation 値 Log clothing reduction 値 90 1 99 2 99.9 3 99.99 4 99.999 5 b) Preparation of TCS saturated aqueous solution: A 4-liter flask was filled with a 3-inch magnetic stir bar and about 7.5 grams of TCS and 3 liters of water. Then place this flask in -36- This paper size is in accordance with Chinese National Standard (CNS) A4 (210 X 297 mm) 546149 A7 ___B7 V. Description of the invention (34) Stir in a water bath and heat (40-45 ° C ) At least 8 hours. Remove the flask containing the obtained TCS / water suspension from the water bath, and filter the warm suspension (please read the precautions on the back before filling this page) through a Whatman # 40 (5 · 5 cm) filter paper C〇〇rs # 32-Η Porcelain

Buchner funnel. This filter combination was then emptied into a 2 liter empty filter flask and filtered in batches. The filtrate was then transferred to another 4-liter flask and cooled. Typically, T C S fine needle crystals form after the filtrate is stored at room temperature for several days. In some timed sterilization studies, the Tcs ί grain solution was filtered under A hnt before being used in the study. In other timed sterilization studies, a small amount of crystalline T C S was kept in the test container to ensure saturation when the temperature changed. It is assumed that the T c s crystals in the time sterilization test container do not affect the test results' because the crystalline T C S does not affect bacteria (that is, is not dissolved). To determine the concentration of T CS in an aqueous solution, the filtered sample was analyzed by HPLC (triplicate). The device used to filter this solution was whatman AUTOVIAL㊣, using a 0.45 micron PTFE membrane and a glass microfiber pre-filter cat · No · AV125UORG. The T CS concentration was calculated using a linear regression line (Micrrosft EXCEL® software) that was matched to one of the TCS / IPA standards included on the same HPLC HPLC. Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs c) Preparation of T C S / surfactant composition aqueous solution: A French square bottle was fed with a solution containing different concentrations of the surfactant and 0.3% by weight of T C S. This mixture is shaken off and heated (35-400) for several hours until T C S is dissolved. The heating was controlled by a variable transformer controlled heating lamp and the temperature of this solution was monitored with a digital thermometer. Stir and then stop. -37- This paper size applies the Chinese National Standard (CNS) A4 (210 X 297 mm) 546149 Printed by A7 ____ Β7 of the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 5. Description of the invention (35) TCS seed (About 1 mg) was added to the solution, and the mixture was left to stand at about 20 ° C. After several days, crystals were observed at the bottom of the solution container, and the maximum solubility of TCS was exceeded in the solution. The approximate surfactant concentration required to almost completely dissolve 0.3% TCS was determined using an experimental design in which the surfactant concentration was reduced by a factor of two for a series of samples until T c S was observed at the surfactant Up to the approximate saturation point. Then the concentration difference 値 (saturated 値 relative to freshly dissolved 分) is halved until a near end of T c s saturation can be measured. The saturation point of the T C S / surfactant composition can be effectively estimated with a small scale (J 5 to 100 ml) sample, but approximately 6004 ⑼g of sample is required to obtain a reliable final result. Therefore, the starting range was established using a small-scale sample, and the final concentration was determined using a larger-scale sample. d) Preparation of a composition comprising T C S, a light-based solvent and a solubilizing agent: First, T C S is dissolved in a solvent used in the composition. Water was then added to the τ c s / -solvent composition, and then about 1 mg of T c S seed crystals were added, and the resulting mixture was allowed to crystallize at about 20 ° c. In a composition containing a solvent, a solubilizing agent and a surfactant, tcS is dissolved in a solvent as described above 'and then the solubilizing agent and the surfactant are added to the TcS / solvent solution. The resulting mixture was then diluted with water to the total batch. If necessary, also adjust the pH. The mixture was stirred at room temperature for about one hour, TcS seeds were added, and the mixture was allowed to crystallize as described above. In addition, the aforementioned method is also used to determine the τ C S saturation point (that is, to halve the surfactant concentration). Similar methods to those described above to determine the maximum additive concentration have been used in the literature. For example, ‘p H. Elworthy et al.,“ Solubilization by -38- This paper size is applicable to the Chinese National Standard (CNS) A4 specification (21G x 297 cm)-(Please read the precautions on the back before filling in this page)

546149 A7 B7 V. Description of the invention (36) surface-active agents and its application in chemistry and biological sciences / 5 Chapman and Hall, Ltd., London, pp. 62-65 (1968), describing the observation by observing the turbidity of the mixture Determine the concentration near saturation. A similar technique involves observing the sample at right angles by using a high-intensity light from a small flash lamp equipped with a beam focusing attachment (i.e., MINI MAGLITE® AA, MAG Instruments, California, US A). This method is also used in very near saturated solutions to enhance the observation of small crystals formed on the bottom of the container. Table 2 summarizes the results of the timed sterilization test performed on the T C S / water composition. The two series of results, I and 11, demonstrate the effect of% saturation in the T C S / water composition, i.e., in a given test series, a decrease in% saturation results in a concomitant decrease in the timed bactericidal efficacy. Surprisingly, as demonstrated in the following examples, the composition of the present invention provides effective timed killing of Gram-positive and Gram-negative bacteria, even if the composition does not contain an active antibacterial compound. (Please read the precautions on the back before filling out this page) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs-39- This paper size applies to China National Standard (CNS) A4 (21〇X 297 male f) 546149 A7B7 V. Description of the invention (37) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs O HH ijj 〇 〇 命 参 S% > 1 Mai H— ^ o Li o I Mai 0 1 Ον $ 1 U) • w 11 ^ 〇U ) U) Ο s two ο • s U \ • o U \ isv rf p > M r 〇Q ο • s — ¥ U \ 今 H 槔 〇is) σ \ h- ^ po ON U \ filial • ο I— k OJ Lh chanto • Private h- ^ Ln filial h- ^ i5V «-fo • g 1- ^ Lh V 1 Jin ο U) Lh K) bo Lh o U \ 孝 〇to s Lh o * U) to 1 — ^ KM i§v rf > 3pp K > V o U \ Jin * K) 00 • K) KJ \ i ^ v rK Lin 4-JS Lh Today 40 paper standards are applicable to Chinese National Standard (CNS) A4 Specifications (210 X 297 mm) (Please read the notes on the back before filling in this page) Order --------- Line. 546149 A7 __ B7 V. Description of the invention (38) Comparison Table 2 and Table 3 Data show at very low TCS concentrations (ie, 5 to 10 ppm) Samples containing higher levels compared with τ C S which time kill efficacy is reduced. For example, the logarithmic decay of a sample containing 0.93 ppm TCS in Table 2 after 15 seconds of contact with E. coli is 0.44, and Table 3—the sample of 484 ppm TCS exposed to the same microorganism in 5 seconds値 is 4.13. This effect is more pronounced during shorter exposures. Another example 'illustrates a more complex composition in the sample in Table 3, namely, 50 ppm TCS (estimated 値) / 10% PG / 5% SXS vs. 448 ppm TCS (estimated 値) / 20% PG / 10 % SXS. Samples with higher T C S concentrations showed a bacterial decay after 1 minute, with at least a logarithmic increase. The data in Table 3 also show that when different solvents / solubilizers are used at approximately the same TCS concentration, their effectiveness is also different. Table 3 further shows that when the amount of the solubilizer in the composition is less than the amount of the polyhydric solvent in the composition, and the composition does not contain an antibacterial agent, the composition has poor timing sterilization performance. Table 3 also shows that if the composition contains only a poly-based solvent or only a solubilizing agent and does not contain an antibacterial agent, the composition will have poor timing sterilization performance. (Please read the precautions on the back before filling this page) The paper size printed by the Employees' Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs applies to Chinese National Standard (CNS) A4 (210 x 297 mm) 546149 A7 B7 V. Description of the invention ( 39) Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs ο ο 1385 895 603 723 510 484 342 110 (est) o 112 (est) TCS (ppm) Table 3-TCS in Solvent and / or Solubilizer System 5% SXS 5% SXS 75.00% PG 50.00% PG 50.00% PG 47.52% PG 45.05% PG 44.20% PG 42.53% PG 41.86% PG 40.01% PG 23.85% PG 17% IPA 17% IPA Solvent / Solubilizer 1.20 / 15 0.15 / 15 > 4.49 / 15 > 5.17 / 30 > 4.69 / 15 > 3.46 / 15 > 5.17 / 30 > 3.46 / 15 4.971} / 302) Staphylococcus aureus 0.33 > 4.43 2.35 0.13 > 4.49 > 5.17 > 4.69 > 3.46 > 5.17 > 3.46 > 5.17 > 4.39 0.42 > 4.42 today-1 0.35 / 15 0.25 / 15 4.45 / 15 4.42 / 30 4.21 / 15 > 4.38 / 15 4.47 / 30 4.13 / 15 4.29 / 30 coliform-0.15 0.96 1.73 0.26 > 4.65 > 4.67 > 4.65 > 4.38 > 4.67 > 4.38 > 4.67 2.37 -0.24 > 3.56 1- ^ 今 42- (Please read first (Notes on the back then fill out this page)

This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) 546149 A7 B7 V. Description of Invention (4G) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 502 (est) ο 50 (est) o 50 (est) o 448 (est) o (ppm) TCS Table 3-TCS 14.5% DPG / 10% SXS 14.5% DPG / 10% SXS 10% PG / 5% SCS 10% in solvents and / or solubilizing systems PG / 5% SCS 10% PG / 5% SXS 10% PG / 5% SXS 20% PG / 10% SXS 20% PG / 10% SXS 5% SCS 5% SCS Solvent / Solubilizer 0.03 / 30 > 3.63 / 30 0.05 / 30 > 4.14 / 30 Staphylococcus aureus 0.04 > 3.63 -0.03 0.59 0.05 3.42 0.05 > 4.14 0.05 3.64 Η- ^ present 0.26 / 30 > 4.44 / 30 1.16 / 30 > 5.25 / 30 E. coli 0.17 > 4.44 0.96 4.96 0.35 3.18 1.35 > 5.25 -0.11 0.80 Jin-43- (Please read the precautions on the back before filling this page) -------- Order --------- This paper size applies the Chinese National Standard (CNS) A4 specification (210 X 297 mm) 546149 A7 B7 V. Description of the invention (41) Printed clothing by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 0ο ο 1385 895 603 723 510 484 342 110 (est) o 112 (est) (ppm) TCS 5% SXS 5% SXS 75.00% PG 50.00% PG 50.00% PG 47.52% PG 45.05% PG 44.20% PG 42.53% PG 41.86% PG 40.01% PG 23.85% PG 17% IPA 17% IPA Solvent / Solubilizer 1.98 / 15 0.54 / 15 3.26 / 15 5.26 / 30 2.60 / 15 > 3.44 / 15 4.61 / 30 2.96 / 15 4.33 / 30 Klebsiella pneumoniae > 3.44 0.63 > 5.04 > 5.64 4.79 > 3.44 > 5.64 > 3.44 5.29 0.89 > 4.11 present 1.34 / 15 0.17 / 15 2.69 / 15 2.92 / 30 1.79 / 15 1.29 / 15 1.56 / 30 1.14 / 15 2.52 / 30 Salmonella cholerae 3.56 0.24 > 4.59 4.33 > 4.50 2.59 2.27 2.31 3.51 1.23 > 3.79 si s S ^ ^ ^ s Ho ^ -44-(Please read the precautions on the back before filling out this page) -Line · This paper size is applicable to China National Standard (CNS) A4 (210 X 297 mm) 546149 Γ Α7 Β7 V. Description of the invention (42) 0 502 (est) 0 50 (est) 0 ulo (est) 0 448 (est) 0 57 TCScppm)

14.5% DPG / 10% SXS

14.5% DPG / 10% SXS

10% PG / 5% SCS

10% PG / 5% SCS

10% PG / 5% SXS

10% PG / 5% SXS

20% PG / 10% SXS

20% PG / 10% SXS

5% SCS

5% SCS (Please read the notes on the back before filling this page) P34 / 30 V4.14 / 30 P22 / 30 V4.32 / 30 P39 V4.14 P37 V4.32 Order --------- Line · Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs P36 / 30 V4.14 / 30 0.25 / 30 3.17 / 30 0.47 V4.14 1.29 V3.68 -45- This paper size applies to China National Standard (CNS) A4 specifications ( 210 x 297 mm) Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs 546149 A7 B7 V. Description of the Invention (43) The following examples show the unexpected benefits achieved by the composition of the present invention. Example 1 This example further demonstrates that neither the polyhydric solvent or the solubilizer itself, or the combination of the polyhydric solvent and the solubilizer, can provide a broad-spectrum, fast-acting, high-performance antibacterial activity. -46- This paper size applies to Chinese National Standard (CNS) A4 (210 X 297 mm) (Please read the precautions on the back before filling this page)

546149 A7 B7 V. Description of the invention (44) Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs ^% 时 # 1 1— ^ U) Η-Α 1 to 1 h— ^ 1 1 1— ^ Ο 1— ^ 1 h -^ 00 Η- ^ h— ^ & 1- ^ U) 1 Life parameters? 〇ο ο Ο ο ο 1— ^ Ln 〇Q o Q o Q 1 hj ooo L / i LO hd Q 荈 ο X ιη Η -* Ϋ〇X Κ) X ιη hk Ο XC / 5 < 1 Ln in X in 1 o GO X 〇〇X 00 Lh X 00 h- ^ o 00 X 00 LA 0〇oo 00 X 00 o 〇 * U ) 00 ο • U) 00 ο U) ΟΝ ο Ο • Κ) ο · oooo • so • soo • U) U) • o Η-Λ U) V 邝 邝 烊 K) ι— ^ is) — ρ Ο ο * U) • oo * ^ o On ol〇V / l U) o 〇o k > σ \ 鳐! 1!!!! O u > Ό 1 1 1 1 o U) < ϊ! 1 1 o On U) 1!! 1!! P! | Is)! 1 p < 1 -47- (Please read the precautions on the back before filling out this page) ·, line · This paper size applies Chinese National Standards (CNS) A4 specification (210 X 297 mm) 546149 A7 B7 V. Description of the invention (45) Example 1 clearly shows that the polyhydric solvent alone is not effective even at a high concentration of 50% Broad-spectrum antimicrobial agent. Similarly, neither the solubilizer alone nor the combination of several solvents and solubilizers can provide an effective antibacterial composition. Example 2 This example demonstrates that a single surfactant, such as a polyhydric solvent alone, a solubilizer, or a blend of a polyhydric solvent and a solubilizing agent, generally cannot provide an effective broad-spectrum antibacterial composition. (Please read the precautions on the back before filling out this page) Clothing printed by the Employees ’Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs-48- This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) 546149 A7 B7 5 Description of the invention (46) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economy K) to 00 to K) Μ U) K) to Composition No. 4% ALS 3% KL 2.5% KO 5% SOS 1.35% ALS 1.6 % SLS 0.48% SLS 0.125% SLS 0.048% SLS Surfactant 3 > > 3.61 0.18 ο 1.76 > 3.97 > 3.94 V 0.56 o Logarithmic decay of Staphylococcus aureus for 1 minute 値 (time sterilization) 0.24 1.74 ο > 4.47 ο 0.67 0.12 o E. coli 0.15 1 1 1 1 II 1 1 II 1 1 1 1 1 1 Klebsiella pneumoniae 0.04 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Salmonella cholerae-49 -(Please read the precautions on the back before filling this page) Order --------- line · This paper size applies to China National Standard (CNS) A4 (210 X 297 mm)

546149 V. Description of the invention (47) In this example, sodium lauryl sulfate (SLS), ammonium acetate sulfate (ALS), and sodium octyl sulfate (sos) are all anionic surfactants. And potassium oleate (KO) and potassium laurate (KL) are anion unloading. Example 3 This example demonstrates that anionic, nonionic, and amphoteric surfactants are not long: a broad-spectrum antibacterial composition for rapid action, even when the surfactant and antibacterial test agent (that is, triclosan or TCS) The same is true when combined. (Please read the notes on the back before filling out this page) Order printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs < -50- This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) 546149 A7B7 V. Description of the invention (48) Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs U) 1 κ > U) I Η- ^ One U) 1 〇 U) U) 00 U) U) ΟΝ U) LO U) U) U > U) 1 h- ^ Life 蓥 ο Ο dd ϋΟ Ο > Η X Ο 00 G 00 C / 5 S γ giant ο Ο Ο Hidden CO _ 00 @ 1 Κ) Κ) Lh k) • Private • ο Ο to U) • ο • ο π: c; c: U) lacquer U) ο ίο S ο ίο S ο ίο ο U) ο LO ο U) ο U) ο * U) o * U) o * U) Η 〇00 U), / Ο Ο ο ο hA σ \ V Κ) Lh VU) Ό • Home ο U \ V to K) to $ 一 p > Today ο ο Ο to ο ο Ο Ο • Private 〇 00 Κ) ο Ο U) Lh c: o U \ 00 * U) Ό Scale -------------------- Order --------- Line (Please read first Note on the back, please fill in this page again) This paper size is applicable to China National Standard (CNS) A4 (210 X 297 mm) 546149 A7 _ B7 V. Description of the invention (49) In this embodiment, sc A and CAPB Amphoteric surfactant. TX100 and AP G are non-ionic surfactants. meaLS, TEALS, KCO, SLES-1 and SLES-2 are all anionic surfactants. Example 3 clearly shows that a wide range of surfactants cannot provide a fast-acting, broad-spectrum antibacterial composition when formulated with an active antibacterial agent. Example 4 This example demonstrates that a composition containing a surfactant, a solubilizer, and a polyhydroxy solvent can provide a surprisingly fast-acting, broad-acting antibacterial activity. The following table is the composition 4-1 to 4-3 compared to the car parent composition No. 0-1-4 and 2 _ 9 comparison 0 ------------% (Please read the back Please fill in this page before ordering) Order --------- line · Printed by the Consumer Cooperatives of Intellectual Property Bureau of the Ministry of Economic Affairs-52- This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) ) 546149 A7 B7 V. Description of the invention (50) Printed clothing-53- U of the Consumer Cooperative of Intellectual Property Bureau of the Ministry of Economic Affairs 4) Composition No. 0.75% ALS 0.75% ALS 〇4% ALS 0.5% ALS surfactant 3 > 5% DPG 5% DPG 20% PG ο 20% PG U) 〇15% AXS 10% SXS ο 10% SXS solubilizer3) > 2.59 4.24 0.05 > 3.61 3.84 Staphylococcus aureus H- ^ Jinhan : Su 遨 〇Ln > 4.5 1.35 0.24 > 4.41 E. coli 0.59 2.57 0.37 0.15 1.49 Klebsiella pneumonia ΙΓ 烊 jit 0.33 4.68 L29 0.04 2.93 Salmonella cholerae ------------- ------- Order --------- Line (Please read the notes on the back before filling this page)

This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) 546149

V. Description of the Invention (51) Examples 1 to 4 prove that the combination of p G and S X S cannot provide an effective antibacterial composition. In summary, Example 1 proves that the polyhydric solvent and the solubilizer alone cannot effectively provide the antibacterial composition. Examples 2 to 9 further prove that the antibacterial composition cannot be provided effectively alone even to the concentration of ALS. However, Example 4-1 illustrates the unexpected characteristics of the combination of multiple light-based solvents, solubilizers and surfactants in providing a broad-spectrum, fast-acting antibacterial activity. The observations on the additive antibacterial properties of Example 4_1 which are not exhaustive 2_9 and b 4 reveal the antibacterial synergistic function of the ingredients of the composition of the present invention, which is surprising and unexpected. Outside. Examples 4-2 and 4-3 further illustrate the synergistic properties demonstrated by the composition of the present invention (ie, Example 4-2) and confirm that the combination of surfactant and solvent (ie, Example 4-3) is still insufficient The antibacterial activity of the composition of the present invention is explained. As illustrated in Example 5 below, the antibacterial composition of the present invention includes a polyhydric solvent such as a diol such as dipropylene glycol, a solubilizing agent such as sodium xylene sulfonate, and a surfactant such as ammonium lauryl sulfate. The composition of the present invention may further contain an active antibacterial agent, such as tricolsan, in order to provide further bactericidal efficacy. As shown below, preferred surfactants include anionic surfactants, such as sulfate, sulfonate, and the like. However, any of the surfactants may be used in the composition of the present invention in the combination of selected solvents and builders. As shown below, it was surprisingly found that a combination of a polyhydroxy solvent, a solubilizer and a surfactant can provide a highly effective antibacterial composition which has been proven to have synergistic activity. Example 5 The following example illustrates the composition of the present invention. This implementation example is practical _ _54_ This paper size is applicable to China National Standard (CNS) A4 (21G X 297 public love) ------ (Please read the precautions on the back before filling this page) Order ---- ----- Line_ Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 546149

V. Description of the invention (52) A combination of multiple secret solvents, solubilizers, and alkaline agents # When inventing the composition, the selected antibacterial agent, such as tdciosan, can be formed with a low percent saturation Or zero, while the composition of the present invention still exhibits high levels of antibacterial activity. The multi-listening agent used in this example is propylene: alcohol, and the surfactant is sodium lauryl sulfate (S? In Table 4 below or ammonium lauryl sulfate (A in Table 4) The solubilizer is sodium xylene sulfonate. Table 4 below outlines the composition of the composition and Table 5 outlines the resistance of their compositions measured by the time sterilization method. -------- ------------- Order --------- line. (Please read the notes on the back before filling out this page) Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs -55 -This paper size is in accordance with Chinese National Standard (CNS) A4 (210 X 297 mm) 546149 A7 B7 V. Description of invention (53 printed by MH h 〇 ^ Tj wdo bd > composition of the Intellectual Property Bureau of the Ministry of Economic Affairs Employee Consumption Cooperative) 0.30 〇 · 〇〇〇0.30 0.30 0.30 0.30 0.30 0.30 0.30 0.30 0.30 0.30 0.30% TCS3) 1 〇〇1 K) 00 U) < 25 100% TCS saturation 0.50 (A) 0.75 (A) 0.25 (A ) 0.25 (A) 1.0 (A) 0.75 (A) 12.0 (A) 9.0 (A) 6.0 (A) 3.0 (A) 1.5 (A) 0.75 (A) 10⑸ 1.5 (S)% Surfactant 3 > 14.4 14.4 14.4 < 1 Lh Ui Lh LA Lh oo% Base Solvent 3 > Η- ^ oo% Solubilizer 3), 4 56- (Please read the precautions on the back before filling this page) --- I --- Order · -------- · This paper size applies the Chinese National Standard (CNS) A4 specification (210 X 297 mm) 546149 Printed clothing A7 of the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs V. Description of the invention (54) HH ffi 〇 ^ Tj W d 〇a > Composition 4.39 / > 4.77 0.79 / 0.9 1.7 / 2.19 > 4.59 / > 4.57 > 3.79 / > 3.79 > 3.79 / > 3.79 > 4.51 ^ 4.51 > 4.51 / > 4.51-/ 4.7 Staphylococcus aureus > 4.71 / > 4.71 > 4.34 / > 4.34 3.97 / > 4.70 > 4.70 / > 4.70 > 3.93 / > 3.93 > 3.93 / > 3.93 > 4.63 / > 4.63 > 4.63 / > 4.63 /0.85-/ 0.95 E. coli 3.00 > 4.55 0.41 / 1.53 0.50 / 1.43 4.06 / > 4.41 .0.17 / 0.92 3.49 / > 3.69 3.74 / > 4.04 > 4. 〇4 > 4.04 2.71 / > 4.36 2.87 > 4.36 3.01 / > 4.38 4.38 / > 4.38 / 0.75 δ Klebsiella pneumonia > 4.20 / > 4.20 > 4.0.4 / > 4.04 3.04 />4.04 > 4.〇4 / > 4.04 > 4.25 / > 4.25 > 4.25 / > 4.25 2.95 ^ > 3.88 3.33 / > 3. 88-/ 0.92 Salmonella cholerae ^ 5-^ φ ^ ϋ ^ > ι30 # / 1 Jin ^ Mo Zhuan ^^^ -57- (Please read the notes on the back before filling this page) Order ---- ----- Line. This paper size applies the Chinese National Standard (CNS) A4 specification (210 X 297 mm) 546149 Printed by the Consumers ’Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs A7 B7 V. Description of the invention (55) Example 5 The composition confirms the surprising and unexpected synergistic antibacterial activity achieved by the combination of solvents, solubilizers and surfactants. Good antibacterial activity can be changed by including an optional active antibacterial agent. A surprising pair of the composition of the present invention is that the antibacterial agent in the composition is less than 25% saturated (i.e., composition E-Η), and even the composition of 0 exhibits antibacterial activity. In particular, the composition Η contains only 2% T C S of saturation. Compositions A and B demonstrate that although compositions lacking solvents and solubilizers exhibit some antibacterial activity, the effectiveness of these compositions is limited, even if fully saturated with T C S. Composition C-Η confirmed that when a synergistic solvent / solubilizing agent / surfactant combination is used, even if the percent saturation of the phenol antibacterial agent (i.e. triclosan) in the composition is very low, that is, less than 25%, it can still form High potency formulation. Compositions I and J illustrate the effect of the weight ratio of solubilizer / polyester based solvent. The ratio of solubilizer / solvent of composition I is 3/1 and can effectively combat Klebsiella pneumoniae, while the increase of composition J The solvent / solvent ratio is 4/3 and it is less effective against the same bacteria. Compositions K, L and M are further examples of the invention. Furthermore, Examples L and M show that the compositions of the present invention can be formulated without active antibacterial agents and still have the efficacy against various bacteria. Composition N illustrates an effective composition of the invention outside the ratio of preferred solubilizer to polyhydric solvent. Example 6 The following examples illustrate other compositions of the invention. This example compares a series of synergistic compositions comprising a polyhydric solvent, a surfactant, and a solubilizer. Certain compositions contain triclsan (Tcs), and some -58- this paper size applies Chinese National Standard (CNS) A4 (210 X 297 mm) ------------- -------- Order --------- Line · (Please read the note on the back? Matters before filling out this page) 546149 A7 B7 V. Description of the invention (56) The composition does not contain activity Antibacterial agents. The results show the overall antibacterial effect of the composition of the present invention. Composition% TCS 3)% DPG 3)% SXS 3)% ALS 3) A 0.30 5 15 0.75 B 0.0 5 15 0.75 C 0.30 5 15 1.5 D 0.0 5 15 1.5 E 0.30 5 15 3.0 F 0.0 5 15 3.0 The results of the timed sterilization of the composition of Example 6 against Staphylococcus aureus and E. coli are summarized. (Please read the precautions on the back before filling out this page) -------- Order --------- Line · Printed by the Consumer Consumption Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs-59- This paper size applies China National Standard (CNS) A4 Specification (210 X 297 mm) 546149 A7 B7 V. Invention Description (57) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 60

woo ω > Life parameter U) 00 V s U) V s U) to Lh V sm Μ 今 摩摩 η L) V Private VIU) bo 00 V 1 VVVVVVVVVVV € VVV (Please read the notes on the back before filling (This page)

This paper size applies the Chinese National Standard (CNS) A4 specification (210 X 297 mm) 546149 A7 ~ ----------- B7 V. Description of the invention (58) The data summarized above proves that although all of the examples A_F are It exhibits a good broad-spectrum antibacterial activity, and the TCS-containing composition (ie, A, c, and F) shows slightly better antibacterial efficacy and is therefore the better. Because of & the composition II of the present invention exhibits good secondary antibacterial efficacy when it does not contain an active antibacterial agent (ie, the% saturation is 0), and the active antibacterial agent, such as Tcs, can further improve the performance of the composition of the present invention . Example 7 This example shows that the composition of the present invention can be used as a hand cleanser. The composition of this embodiment includes a specific example of containing an antibacterial agent in a combination containing a surfactant, a polyhydroxy solvent, and a solubilizer (i.e., Examples 7_A and 7_b). In addition, 'Example 7-C is free of conventional antibacterial agents. The following table summarizes the composition of Example 7. The only other component in the composition is deionized. ----------- 1% C. Please read the precautions on the back before filling this page.) Combination % TCS% DPG _% sxs O / v AT c 7-A 0.30 5 / 〇 / \ JLr b 7 R 0.30 1.5 5 3.0 7 Γ 0.0 5 15 3.0 Composition antibacterial activity result: order ------ --- Line. Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs ~ 1¾¾ ___: r2〇mmmmmm Golden Yellow Check ^^

Examples 7-A to 7-C all showed good homogeneity and stability. In the evaluation by volunteers, Example 7.B and 7_c have excellent encapsulation -61-This paper size applies Chinese National Standard (CNS) A4 specifications (210 X 297 public love 546149 A7 B7 V. Description of the invention (59) Yes, as shown in the data above, even Example 7-C, which does not contain active antibacterial agent tridosan, exhibited a high-efficiency and broad-spectrum antibacterial effect. In addition, the examples with TCS percent saturation were significantly less than 25% 7_B also shows a good broad-spectrum antibacterial activity. This example illustrates that when it is necessary to emphasize other advantages of the composition of the present invention containing a high surfactant concentration and a small amount to no antibacterial agent, a TCS with a low% saturation can be prepared. Effective antibacterial composition. Example 8 This example illustrates the effect of TCS% saturation in a composition containing multiple base solvents, solubilizers, and surfactants. The antibacterial efficacy can be demonstrated from the data summarized in the table below The gain (measured by the time sterilization test) is related to the increase in the% saturation of the antimicrobial agent in the given composition. The following table shows the changes in the TCS concentration when the concentration of all other ingredients remains the same. (Please read the notes on the back before filling out this page) — — — — — — — — — — — — — — — — — — Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs -62- This paper size applies to China Standard (CNS) A4 specification (210 X 297 mm) 546149 A7 B7 V. Description of the invention (60) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs · 〇 σ \ Os oo io 00 o lo oo lo u > o 〇Lo? 〇o LO Η 3. g- C / 3 § U) \ lii # Η £ 〇 ^ 芩 推-^ λ 13¾ S & ^ WU \ ο Lh X Ο, ϋ〇Lh s U \ 00 X ϋ〇〇 U \ hd ϋ P 00 X 00 o, 00 «s capacity GO X 00 o, 00 hd OP 〇〇X 00 o 00 OP HA capacity 00 X j / 5 o, dp h- ^ Lfi X ϋ〇 〇, ϋ〇op name lil X ϋ〇o, 00 this U) 兰 sg daddy 1— ^ o * ^ ο U) hA MD 〇 \ • s U) • s • s V LA U \ V Private Lh VV Private / l VU \ Lh V Ln V Private Ln Lh V Private l / i Lh w Select K 烊 β Refer to * U) o VU) bo K) 2 bo H- ^ K) VU) bo U) • g VU) bo H- ^ u > 2 bo U) bo VU) bo bo 1— ^ VU) bo w ^ -63- (Please read the precautions on the back before filling (Write this page) order --------- line. This paper size is applicable to China National Standard (CNS) A4 (210 X 297 mm) 546149 A7 V. Description of invention (61) Employees of Intellectual Property Bureau, Ministry of Economic Affairs Consumer cooperatives have printed the antibacterial composition of the present invention with several practical end uses, including: ΓΓ cleanser, surgical cleanser, body detergent, and hand care products. Other types of compositions include fortune: t mousse (mou⑽), etc., and organic and inorganic 2 :: compositions such as lotions, lotions, creams, creams, etc. The present invention: ΐ 理 :: is an antibacterial cleaner for hard surfaces, such as hospitals, canteens, and meat sinks and pans. The antibacterial composition of the present invention can be made into a thinner ready-to-use composition, or a thick wall using a material release. The object can also be mixed with a piece of cloth to make an antibacterial wipe. This anti-toxin / eye cleanser disinfects skin or inanimate surfaces.柷 # 月 柷 菌, and the compound provides the advantage of extensively killing Gram and Gram-negative bacteria in a short contact time. From the typical 15 to 60 seconds used to clean and disinfect the skin and 4〒 surface, the short contact time which can cause substantial logarithmic decay of the bacteria is important. Because the composition of the present invention does not rely on traditional active antibacterial agents to reduce the number of micro-groups, the composition of the present invention can be effective in a short contact time. Since the bactericide does not exist in the surfactant gel particles, this' this The inventive composition is able to immediately begin to degrade the flora. Moreover, the composition of the present invention may contain no antibacterial agent, but still exhibit good antibacterial properties. The following examples illustrate various compositions of the invention. Example 9 Hand Sanitizer Combination ^ A composition suitable for use with a hand sanitizer according to the present invention was prepared. The composition of the present invention includes the following compositions containing the indicated weight percentages:

-64- 546149 A7 V. Description of the Invention (62) Ingredients

Triclosan ammonium lauryl sulfate ___ Tris propylene glycol xylene sulfonate steel deionized water weight percentage 0.30 0.50 14.4 10.0 The amount of composition printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs is prepared by dipropylene glycol and τ CS Mix until even sentences (,,, spoon 5 knife clocks). After triclosan is completely dissolved, as confirmed by the absence of undissolved solid material, sodium xylene sulfonate is added to the solution. The resulting mixture was then stirred until the sodium xylene sulfonate was completely dissolved. Finally, ammonium lauryl sulfate and water were added to the resulting solution, and the composition was stirred until homogeneous (about 5 minutes). The composition has a solubilizer to solvent weight ratio of about 1: 144 and contains about 50 = saturation of tricloxasan. The composition was evaluated for its antibacterial efficacy by a timed bactericidal test against Staphylococcus aureus, E. coli, Klebsiella pneumoniae and Salmonella cholerae through a contact time of 30 seconds. The compositions exhibited antibacterial logarithmic decay 4.3 of 4.39, > 4.71, 3.00, and > 4 2 0, respectively. Therefore, the composition of the present invention shows excellent broad-spectrum antibacterial activity. In this practice, when the weight ratio of various ingredients is out of the preferred range, an effective embodiment of the present invention can still be obtained. However, as shown elsewhere in this article, the better example offers other advantages. Example 10 0 Body decontamination composition A composition suitable for use as a body decontamination agent according to the present invention is prepared with the following ingredients: the following weight percentages:-65- x 297 mm) ----- ---------------- Order --------- Line · (Please read the notes on the back before filling this page) 546149 V. Description of the invention (63

Weight percent

Triclosan alkyl polysaccharide 荅 0.10

The composition of the present invention is obtained by combining trielosan, propylene glycol, flavor, and ethanol, and mixing the ingredients until all triclosan is dissolved, as seen by the absence of undissolved substances. Then, sodium xylene sulfate was added, and the resulting mixture was stirred until the sodium xylenebenzene sulfate was completely dissolved. Finally, the alkyl polysaccharide hydrazone and water were added, and the mixture was stirred until homogeneous. The resulting composition forms a refreshing body detergent that provides the desired level of bacterial degradation on the skin of the user. Example 1 1 Wet wipe composition According to the present invention, a composition suitable for being impregnated into a non-woven cloth to make a wet wipe can be prepared with the following ingredients at the weight percentages shown below: -------- ^ ---- ----- Line—9. (Please read the notes on the back before filling this page) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs. Triclosan 0.20 ammonium lauryl sulfate 5 dipropylene glycol 10 xylene sulfonic acid Sodium 20 Deionized water in an appropriate amount The composition is prepared by mixing dipropylene glycol and τ cs (approximately -66- this paper size applies the Chinese National Standard (CNS) A4 specification (210 > < ^ 97mm) A7

546149 V. Description of Invention (64) Five minutes). After triclosan is completely dissolved, as seen from the absence of undissolved material, sodium xyloxalate is added to the solution. The resulting composition was then stirred until the sodium xylene sulfonate was completely dissolved. Finally, lauryl sulfate and water were added to the resulting solution, and the composition was stirred until homogeneous (about five minutes). A piece of non-woven fibrous cloth (that is, a commercially available paper towel) is then dipped into the composition to form a wet wipe, which is suitable for wiping and cleaning surfaces, such as hands or non-biological surfaces such as counters. This article forms a good wet wipe having good cleaning characteristics and providing a broad-spectrum antibacterial activity. Example 1 2 Hand Sanitizer Composition A composition suitable for use as a hand sanitizer according to the present invention is prepared. The composition contains the following ingredients in weight percent shown: (Please read the precautions on the back before filling out this page) Ingredient weight percent Triclosan 0.30 ammonium lauryl sulfate 6 dipropylene glycol 5 sodium xylene sulfonate 15 deionized water qs this The composition is prepared by mixing dipropylene glycol and T cs until homogeneous (contracted --------- line · Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs

" I was plated). After the complete solution of rnciosan ^, it is possible to sigh about the insoluble matter and water Γ. Seen by adding sodium xylene sulfonate to the solution. The resulting mixture was then stirred until the sodium xylene sulfonate was completely dissolved. Finally, ammonium lauryl sulfate was added to the solution, and the composition was stirred until homogeneous (about 5 minutes). The solubilizer-to-solvent weight ratio of the composition was 3: 1 and the saturation of Mclosan was about 8%. The composition is based on golden yellow-67- 546149 A7 for one minute contact time. V. Description of the invention (65 Staphylococcus, E. coli, Klein pneumonia I. Foot-time bactericidal test to evaluate its antibacterial logarithmic effect. > 3 79, > 3 93 The composition shows excellent broad-effect resistance to solubilizer-to-solvent weight ratio and the advantage of including a good specific example. Furthermore, it is formulated by a more concentrated surfactant The composition of the invention has excellent foaming stability in the hand-washing test of volunteers. Obviously, the foregoing can be modified and mutated without departing from the purpose of the present invention and the scope of patent application. The Bordetella and The composition of Salmonella choleraesuis. The composition exhibits individual > 4.36 and > 4.25. Therefore, the bacterial activity. This example demonstrates that an active antibacterial agent of the present invention can achieve other advantages over the exemplified effective composition. For example, the present invention with improved good bubble characteristics and clarity enumerates many repair scopes 'and therefore' only appended (please read the note on the back? Matters before filling in this ) Ministry of Economic Affairs Intellectual Property Office employees consumer cooperatives printed paper _ 68 wide scale applicable to Chinese National Standard (CNS) A4 size (210 X 297 mm)

Claims (1)

546149 Patent Application No. 089112408 Chinese Patent Application Replacement (May 1992) An antibacterial composition comprising (a) 1% to 50% by weight of a polyhydroxy solvent; (b) 1% to 50% by weight of a solubilizer; (c) 1%! % To 25% by weight of a surfactant; (d) 0% to 5% by weight of a 2,4, trichloro-2, -quinyl-diphenyl ether (tric 1 0sa η) antimicrobial agent; and (e) water, wherein the weight ratio of the solubilizer to the polyhydroxy solvent is 1: 丨 to 6: 1; and wherein the composition is measured at a contact time of 30 seconds as measured by S. aureus It can provide 2 to 5 logarithmic attenuation of Gram-positive bacteria, and according to E. coli's measurement, the composition can provide 2.5 to 5 anti-gram-negative ^ logarithmic decay after 30 seconds contact time. value. ^ 2. The composition according to item 1 of the patent application range, wherein the weight ratio of the solubilizer to the poly-green solvent is 1.5: 1 to 5: 1. 3. The composition according to item 1 of the patent application range, wherein the weight ratio of the solubilizer to the multi-solvent solvent is 2: 1 to 4: 1. 4. The composition according to item 1 of the application, wherein the content of the polyhydroxy group is 5% to 25% by weight. 5. The composition according to item 1 of the patent application range, wherein the content of the polyhydroxy group is 5% to 15% by weight. 6. The composition according to item 1 of the scope of patent application, wherein the polyhydric solvent includes glycols, triols, polyols and combinations thereof. 7. The composition according to item 1 of the scope of patent application, wherein the paper scale of the polyhydroxyl engraved envelope is applicable to the Chinese National Standard (CNS) A4 specification (210 X 297 mm) 546149 A BCD Drunk, propylene glycol, glycerol, diethylene glycol, dipropylene glycol, tripropylene glycol, hexanediol, L3-butanediol, butylene glycol, 152,6-hexanetriol, sorbitol, PEG-4, PEG -6, or a mixture thereof. 8. The composition according to item 1 of the patent application range, wherein the content of the solubilizer is from 5 to 30% by weight. 9. The composition according to item 1 of the patent application range, wherein the content of the solubilizer is 10% to 30% by weight. 10. The composition according to item 1 of the patent application, wherein the solubilizing agent is selected from the group consisting of sodium cumenesulfonate, ammonium cumenesulfonate, ammonium xylenesulfonate, and toluenesulfonic acid Potassium, sodium toluenesulfonate, sodium xylenesulfonate, toluenesulfonic acid, xylenesulfonic acid, sodium polyfluorenesulfonate, polystyrene% Hanshin Steel's methyl tea horizontal acid steel, disuccinate, and Mixture 0 11. The composition according to item 1 of the patent application, wherein the content of the surfactant is 2% to 20% by weight. 12. The composition according to item 1 of the patent application range, wherein the content of the surfactant is 2% to 15% by weight. 13. The composition according to item 1 of the patent application range, wherein the surfactant is selected from the following combinations: anionic surfactant, cationic surfactant, nonionic surfactant, amphiphilic interface Positioning agents, and mixtures thereof. 14. As the scope of patent application! The composition of item, wherein the surfactant comprises an anionic surfactant. 15. If the composition of the scope of patent application item 1, wherein the anionic interface activity -2-this paper size applies Chinese National Standard (CNS) A4 specifications (210 X 297 mm) 546149 AB c D π, scope of patent application The agent is selected from the group consisting of: C8-Ci8 alkyl sulfate vinegar salt, Cs-Cu fatty acid salt 'c8-c18 alkyl ether sulfate salt having 1 or 2 mole ethoxy groups, c8-c18 Alkylamine oxides, c8_Cl8 sulfosuccinates, C8-C18 alkyl diphenyl ether disulfonates, c8-C18 alkyl carbonates, CVCu α-fluorene hydrocarbons, methyl esters, And its mixture. i6. The composition according to item 1 of the scope of patent application, wherein the content of the 2,4,4'-trichloro-2 1 -yl-diphenyl ether (tric 1 〇sa η) antimicrobial agent is 0.01% to 3 %. 17. The composition according to item 1 of the patent application range, wherein the content of the phenolic antimicrobial agent is 0.01% to 1%. 18. The composition according to item 17 in the scope of patent application, wherein the content of the 2,4,4, -trichloro-2f-acrylic acid · dibenzoic acid (tric 1 〇sa η) is at room temperature 2% to 100% saturation in down measurement. 19. The composition according to item 16 of the scope of patent application, wherein the content of the 2,4,4, -trichloro-2 '-^-diphenyl ether (triclosan) antimicrobial agent is measured at room temperature as: 25% to 100% saturation. 20. The composition according to item 16 of the scope of patent application, wherein the content of the 2,4,4, trichloro-2'-kilyl-dibenzoic acid (tric 1 0sa η) antimicrobial agent is at room temperature The measurement is 50% to 100% saturation. 21. The composition according to item 1 of the patent application scope, further comprising: 0% to 20% by weight of water-soluble Sf * containing 1 to 6 carbon atoms; and 0% to 5% by weight of gelling Agent, wherein the amounts of the water-soluble alcohol and the gelling agent are not 0 weight at the same time. / 〇. -3-This paper size is in accordance with Chinese National Standard (CNS) A4 (210 X 297 mm) 546149 AB c D 6. Application scope of patent 22 · If the composition of the scope of patent application No. 21, the alcohol is selected from Among the following combinations: methanol, ethanol, isopropanol, n-butanol, n-propanol, and mixtures thereof. 23. A composition as claimed in claim 21, wherein the gelling agent includes natural polymers, synthetic polymers, derivatives of natural polymers, and mixtures thereof. 24. The composition according to item 1 of the patent application scope, which has a ρ Η value of 5 to 8. 25. The composition according to item 1 of the patent application scope, comprising: (a) 5 to 15% by weight of a polyhydroxy solvent; (b) 2% by weight. To 20% by weight of solubilizer; and (c) 5% to 20% by weight of anionic surfactant. 26. The composition according to item 25 of the patent application scope, which further comprises 0.05 to 1% by weight of 2,4,4, -trichloro-2, -hydroxy-diphenyl ether (tric 1 〇sa η) antimicrobials. 27. The composition according to item 26 of the patent application range, wherein the content of the 2,4,4, -trichloro-2 ′-# to di-diphenyl ether (tric 1 〇sa η) antimicrobial agent is in the room At least 25% saturation when measured at temperature. 28. The composition as claimed in claim 25, wherein the polyhydroxy solvent includes propylene glycol, dipropylene glycol, or a mixture thereof; the solubilizer includes xylene dibasic acid salt; and the surfactant includes c8 < i8 alkyl sulfuric acid Ester salt. A method of reducing the surface radon group ', which includes contacting the surface with the composition as described in the first scope of the patent application for 30 seconds to achieve golden yellow grapes. -4- The paper size applies the Chinese National Standard (CNS) A4 specification ( 210X297 mm) '^ 546149 : The logarithmic decay value of the bacteria and 2.5 to 5 for the large intestinal bacteria. It further includes cleaning the composition from the surface, wherein the surface is lactating, wherein the surface is hard, wherein the composition is the same as the method of item 29 in the scope of patent application No. 29. 31. The skin of the method as claimed in item 29 of the patent. 32. The method of applying for the scope of the patent No. 29 can express the life surface. 33. If the scope of the patent application is 2y cents, the composition is in contact with the surface for 60 seconds to reach the current position. The second female J nail Jin Yin and the chromococcus are 3 Logarithmic impairment to 5. If you apply for patent No. 29 in the scope of patent application, the number of old solid coins is 0, and the composition is in contact with the surface for 30 seconds to achieve a sample size of 3.75. Logarithmic attenuation value to 5 0 -5- This paper size applies to China National Standard (CNS) A4 specification (210X297 mm) --------