TW542731B - Mouth member for mixed filling processing and infusion container using the mouth member - Google Patents
Mouth member for mixed filling processing and infusion container using the mouth member Download PDFInfo
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- TW542731B TW542731B TW91113614A TW91113614A TW542731B TW 542731 B TW542731 B TW 542731B TW 91113614 A TW91113614 A TW 91113614A TW 91113614 A TW91113614 A TW 91113614A TW 542731 B TW542731 B TW 542731B
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- valve body
- infusion
- container
- infusion container
- opening
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1443—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters
- A61J1/145—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters using air filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1443—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters
- A61J1/1456—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters using liquid filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/202—Separating means
- A61J1/2024—Separating means having peelable seals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2093—Containers having several compartments for products to be mixed
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- Health & Medical Sciences (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
Description
542731542731
542731 五、發明說明(2) 輸液容器的密封性者。 發明之揭示 本發明者等,為了解決上述課題而進行刻意的研究之結 果,發現到下述之嶄新的事實,而得以完成本發明。其 為·作為用以形成輸液容的混注開口之構件,係以具備 有用以保持、繫止或螺合用於混注處理之注射器等之注入 構件的大致圓筒狀的插入口 ,再者,具備有用以防止在其 内部自藥液容器流出藥液之回流阻止閥,與用以防止自藥 液容器的外部之雜物的混入的過濾器;於使用此構件時, 於往輸液容器内進行藥液等的混注處理之時,不會有彈性 體的碎屑或薄膜的碎片之混入的顧慮,而且於混注處理之 後亦可確保輸液容器的密封性。 亦即,用以解決上述課題的本發明之混注處理用開口構 件,係裝設於藥液容器上之用以區隔混注處理用開口部之 開口構件;其特徵在於,係具備有: (i )向著藥液容器的外部側配置之大致圓筒狀的插入 v , (i i )配置於輸液容器的較該插入口更内部側之用以關閉 藥液的流通,且若自上述插入口側承受流體壓,則可讓藥 液流通之回流阻止閥,與 (i i i )過濾器。 依據上述本發明之混注處理用開口構件,不須經過將彈 性體穿刺或將薄膜刺破之操作而可施行混注處理。因而, 於混注處理時,不會發生彈性體的碎屑或薄膜的碎片,因542731 V. Description of the invention (2) Sealability of infusion container. Disclosure of the Invention As a result of deliberate research to solve the above-mentioned problems, the present inventors have discovered the following novel facts and completed the present invention. As a member for forming an infusion opening for an infusion volume, it is a substantially cylindrical insertion port provided with an injection member for holding, locking, or screwing a syringe for infusion processing, and the like. A backflow prevention valve to prevent the medicine liquid from flowing out of the medicine liquid container in the inside, and a filter to prevent the inclusion of foreign substances from the outside of the medicine liquid container; when using this component, the medicine liquid is carried into the infusion container In the case of mixed injection processing, there is no concern about the inclusion of elastomer chips or film fragments, and the sealing performance of the infusion container can be ensured after the mixed injection processing. That is, the opening member for co-injection processing of the present invention for solving the above-mentioned problems is an opening member installed on a medicinal solution container to separate the opening portion for co-injection processing, and is characterized in that: (i ) A substantially cylindrical insertion v disposed toward the outer side of the medicinal solution container, (ii) An infusion container disposed on the inner side of the infusion container to close the circulation of the medicinal solution, and if received from the above-mentioned insertion port side, Fluid pressure, the backflow prevention valve that allows the liquid to flow, and (iii) the filter. The above-mentioned opening member for coinjection processing according to the present invention can be subjected to coinjection processing without the need to pierce the elastomer or pierce the film. Therefore, chipping of the elastomer or chipping of the film does not occur during the infusion process.
91113614.ptd 第5頁 542731 五、發明說明(3) 此,不會有 兼具有回流 之混入。 再者,本 之回流阻止 等之輸液容 亦可期以防 由上述的 適用於用以 本發明之 閥係具備: 所構成的閥 上述閥體 流通,自上 與上述閥座 經由自上述 液容器往内 上述閥座 該藥液流 之流體壓之 述流體壓之 上述閥體 方向與於上 為佳。 發生此等碎屑等之誤混入的顧慮。而且,由於 阻止閥與過濾器,可防止自外部之雜物或細菌 發明之混注處理用開口 閥,不只在混注處理之 器之製造時,或於保管 止藥液等之漏出。 理由,本發明之混注處 區隔輸液容器的混注開 混注處理用開口構件中 連通於上述(i)的插入1: 體、自上述插入口側連 ,為配置於上述圓筒體 述插入口側承受流體壓 之間形成藥液流入用的 輸液容器的内部側連接 部側之移動者; 具備有藥液流通孔; 通孔,於上述閥體不承 時,經由該閥體可關閉 時則打開,與上述空隙 與上述閥座,以使上述 述空隙部中之藥液流動 構件,由於具備有上述 後,而且在滅菌處理時 、搬運輸液容器之時, 理用開口構件,為極為 口之構件者。 ,上述(i i )的回流阻止 7之圓筒體、由彈性體 接到該閥體之閥座; 的内部用以關閉藥液的 ,則容易壓縮變形而在 空隙部者,且於該閥體 之固定部可限制往該藥 受到來自上述插入口側 ,且上述閥體於承受上 部相連通; 流體壓對該閥體之施壓 方向相交叉的方式配置91113614.ptd Page 5 542731 V. Description of the invention (3) Therefore, there will be no mixing with reflow. In addition, the infusion capacity of the backflow prevention and the like can also be expected to prevent the above-mentioned valve system applicable to the present invention from being provided with a valve constituted by the above-mentioned valve body, flowing from above with the above-mentioned valve seat through the above-mentioned liquid container. It is preferable that the direction of the above-mentioned valve body of the fluid pressure of the fluid pressure in the valve seat above the valve seat is the same as above. There is a concern that such debris may be erroneously mixed. In addition, the stop valve and filter can prevent the opening of the valve for mixing processing from foreign debris or bacteria, not only during the manufacturing of the mixing processing device, but also for preventing leakage of the chemical solution. The reason is that the opening member for mixing opening and mixing processing of the infusion container for injecting the infusion container according to the present invention communicates with the insert 1 of the above (i): body, which is connected from the insertion port side, and is arranged on the insertion port side of the cylinder A person who moves on the inner side of the infusion container of the infusion container for injecting the medicinal fluid between the fluid pressures; is provided with a medicinal fluid circulation hole; a through hole is opened when the valve body can not be closed by the valve body With the gap and the valve seat, the chemical liquid flowing member in the gap portion is provided with the above-mentioned, and during the sterilization process, and when the liquid container is transported, the physical opening member is an extremely mouthful member. By. (Ii) The backflow prevention cylinder of (ii) above is connected to the valve seat of the valve body by an elastomer; the inside of the valve body is used to close the medicinal solution, and it is easy to compress and deform into the gap, and the valve body The fixed part can restrict the medicine from coming from the above-mentioned insertion port side, and the valve body is communicated with the upper part; the pressure direction of the valve body is arranged to intersect with each other.
91113614.ptd 第6頁 54273191113614.ptd Page 6 542731
五、發明說明(4) 依據上述之較佳 t 注開口之具備有回且二即,本發明之輸液容器用混 造簡單,製造亦容mt;儘!回流阻止間本身的構 器的密封性更佳優異万θ施行混注處理後之輸液容 器的製造時等之優異的密2到施行混注處理後及輸液容 、f ΐ ΐ混注處理用開口構件的較佳樣能中 述閥體的彈性體,铨樣恶中,以用以形成上 2鳥、遂縮永久以=以=°, 經由以上述熱塑性彈性…、塑性彈性體為佳。 壓縮變形性與回復性作成良好成閥-,可使回流阻止閥的 於本發明之混注處理用開口構件中 :入…於其外周面上具有突起物或二;大致圓筒狀的 1内螺紋之外筒部與具備有嵌插用的内ϋ為與具備 尘(lure l〇ck)注入具為可螺合者為佳。。之吸引-鎖緊 外周面設置突起物或螺紋,㈣於混错由在插入口的 注入構件具備有所謂的吸引_鎖緊型繫外理之注射器等之 該注入構件與上述插入口螺合,可作。^的情況,可使 者。 馬各易保持與繫止 再者,於本發明之混注處理用開口構件 的孔徑宜為0.1〜10"m,係以在使得藥中」上述過濾器 順利地達A,並確實地防止自外部的雜?的混注處理 量下,為較佳t。上述過渡器的孔徑,〜11的硯點考 0· 15〜0. 25 更佳。此情況下,不只可防述靶圍中尤以 之類的雜物之混入,且可確實地防止自 掉性體的碎屑 1 °卩的細菌之混 542731 五、發明說明(5) 入° 本發明之 口構件之任 依據此輸 部達成。而 混注處理用 或將薄膜刺 理時不會產 發生此等碎 阻止閥及過 藥液容器中 又,本發 閥,故不只 容器之製造 防止内容液 由上述的 及處理後之 為可實現安 上述輸液 數室,可將 其等混合而 於本發明 者。由於脂 物混入内部 輸液容 一者與 液容器 且,混 開口構 破之操 生彈性 屑等之 渡器, 〇 明之輸 在混注 時,或 等之漏 理由, 内容物 全的投 容器, 複數的 供給。 之輸液 肪乳劑 的情況 器,係具 内容物之 ,混注處 注處理用 件來區隔 作而可施 體的碎屑 誤混入的 故可防止 液容器, 處理之後 於保管、 出。 本發明之 的漏出, 藥之輸液 經由具備 輸液隔離 容器中, 是不透明 ,要以眼 備上述本發明之混注處理用開 排出用開口部所構成。 理與排出處理可在不同的開口 的開口部由於係經由本發明的 者,故不須經過將彈性體穿刺 行混注處理。因而,於混注處 或薄膜的破片,因此,不會有 顧慮。再者,由於具備有回流 自外部之雜物或細菌之混入到 由於具備有上述的回流阻止 ,而且在滅菌處理時等之輸液 搬運輸液容器之時,亦可期以 輸液容器,可防止混注處理時 且不會有混入雜物的顧慮,作 容器是極為適合者。 有可打通之間隔壁來隔開之複 保存,於需要時打通間隔壁使 可舉出例如容納著脂肪乳劑 者,於彈性體的碎屑之類的雜 睛來確認是極為困難的。而, ilillV. Description of the invention (4) According to the above-mentioned preferred t, the opening of the injection opening is provided with the second and second, that is, the infusion container of the present invention is simple to mix and can be manufactured with mt; do! The structure of the backflow prevention chamber itself has better sealing performance. Excellent in the production of the infusion container after the infusion treatment is performed. 2 The infusion container is filled with the infusion volume and f ΐ ΐ. The good body can describe the elastic body of the valve body, which is used to form the upper two birds, and then shrink permanently to = to = °, preferably through the above-mentioned thermoplastic elasticity ..., plastic elastic body. Compression deformability and recovery make a good valve-it can make the backflow prevention valve in the opening member for mixing processing of the present invention: into the outer peripheral surface with a protrusion or two; approximately cylindrical 1 internal thread It is preferable that the outer tube part and the inner part provided with the inserting part are screwable with the lure 10 injector. . The suction-locking outer peripheral surface is provided with a protrusion or a screw thread. The injection member at the insertion port is provided with a so-called suction-locking type syringe and the injection member is screwed with the insertion port. Available. ^ 'S situation can be made. In addition, Ma Geyi maintains and stops the pore diameter of the opening member for the mixed injection processing of the present invention should be 0.1 ~ 10 " m, so that the above-mentioned filter can reach A smoothly, and can be prevented from the outside. Miscellaneous? Under the mixed injection throughput, it is better t. The aperture of the above-mentioned transitional device is 1111 ~ 0 ~ 25. In this case, not only the inclusion of debris in the target range can be prevented, but also the debris of the self-falling body can be reliably prevented. 1 ° 卩 Bacteria mixture 542731 V. Description of the invention (5) Entry ° The task of the mouth component of the present invention is achieved according to this section. However, such crushing prevention valves and medicine liquid containers do not occur when mixing injection processing or piercing the film, so this valve is not only used to manufacture the container to prevent the contents of the liquid from the above and after the treatment to achieve security. The above-mentioned infusion chamber can be mixed by the present inventors. Because the fat is mixed into one of the internal infusion volume and the liquid container, and the elastic opening and the like are broken by the mixed opening, the ming is lost during mixing, or the reason for the leakage, the contents are all put into the container, multiple supply. The condition of the infusion fat emulsion is the contents, and the mixing place is filled with processing parts to separate the workable debris, which can be mixed in accidentally, so it can prevent the liquid container from being stored and discharged after processing. The leakage of the drug of the present invention is opaque through the infusion container provided with the infusion isolation container, and is formed by preparing the opening for discharge of the mixed injection treatment of the present invention. The treatment and discharge processes can be performed at different openings. Since the present invention is passed through the present invention, it is not necessary to pierce the elastomer to perform the injection process. Therefore, there is no concern at the mixing place or the broken film. In addition, it is possible to use an infusion container to prevent confusion when it is equipped with a foreign substance or bacteria mixed from the outside to the above-mentioned backflow prevention and when the infusion container is transported during the sterilization process. From time to time, there is no concern about contamination, making it a very suitable container. It is difficult to confirm that there is a partition wall which can be opened, and the partition wall is opened when necessary. For example, a person who contains a fat emulsion and a piece of debris such as an elastomer are extremely difficult to confirm. Whereas, ilill
mm
\\326\2d-\91-09\91113614.ptd 第8頁 542731 五、發明說明(6) 於本發明之輸液容器中,由於在混注處理用開口構件中具 備有過濾器,故不會有於混注處理時及處理後之自該混注 開口的雜物之混入的顧慮。因此之故,本發明之輸液容器 適合於容納脂肪乳劑之用途。 作為上述以可打通之間隔壁來隔開之輸液容器,可舉出 具有以該間隔壁隔開的2室,於一室中容納有含有糖及脂 肪乳劑之輸液,於另一方的室中容納有含有胺基酸及電解 質之輸液。 用以實施發明之最佳形態 接著,就本發明之混注處理用開口構件及使用其之輸液 容器,參照圖式加以詳細地說明。 本發明之使用混注處理用開口構件之輸液容器1 0,例如 如圖1所示般,係具備有内溶液之排出處理用開口部1 1、 與具備有本發明之混注處理用開口構件2 0之混注處理用開 口部1 2的2個開口部者。此輸液容器1 0,亦可為容納室只 有1個之所謂的單室的輸液容器,亦可為具備2個以上的容 納室之所謂的複室的輸液容器。於圖1所示之情況中,容 納室1 4係由以可打通的間隔壁1 3來分離之2室(上部容納室 14a、下部容納室14b)所構成。 作為該間隔壁的形態,並無特別限定,可採用各種公知 的設置。尤其,藉由壓合之可剝離的熱炼合者,於市售的 2室輸液中已被採用著,是較佳者。 於上述的2室容器中,例如在一室中容納含有糖及脂肪 乳劑之輸液,另一方的室中,容納含有胺基酸及電解質之\\ 326 \ 2d- \ 91-09 \ 91113614.ptd Page 8 of 542731 V. Description of the invention (6) In the infusion container of the present invention, since a filter is provided in the opening member for mixing processing, there will be no Concerns about the inclusion of debris from the mixing injection opening during and after the mixing injection treatment. For this reason, the infusion container of the present invention is suitable for the purpose of containing a fat emulsion. Examples of the infusion container separated by the partition wall that can be opened include two compartments separated by the partition wall. One compartment contains an infusion solution containing sugar and a fat emulsion, and the other compartment is housed in the other compartment. There are infusions containing amino acids and electrolytes. Best Mode for Carrying Out the Invention Next, the opening member for co-injection processing of the present invention and an infusion container using the same will be described in detail with reference to the drawings. The infusion container 10 using the opening member for infusion processing according to the present invention is, for example, as shown in FIG. 1, provided with an opening portion 11 for discharging treatment with an internal solution, and the opening member 2 with infusion processing according to the present invention. One of the two openings of the injection processing openings 12. The infusion container 10 may be a so-called single-chambered infusion container having only one accommodating chamber, or a so-called multiple-chambered infusion container having two or more accommodating chambers. In the case shown in Fig. 1, the accommodating chamber 14 is composed of two chambers (the upper accommodating chamber 14a and the lower accommodating chamber 14b) separated by a partition wall 13 which can be opened. The form of the partition wall is not particularly limited, and various known arrangements can be adopted. In particular, a peelable hot-melt blender by compression bonding has been used in a commercially available 2-chamber infusion solution, and is preferred. In the above-mentioned two-chamber container, for example, one chamber contains an infusion solution containing a sugar and fat emulsion, and the other chamber contains an amino acid and an electrolyte.
\\326\2cl-\91-09\91113614.ptd 第9頁 542731 五、發明說明(7) 輸液。藉此,可迴避經由糖與胺基酸的梅勒反應 (M a i 1 1 a r d r e a c t i ο η )及因於電解質之脂肪乳劑的凝集。 (回流阻止閥) 本發明之混注處理用開口構件20之回流阻止閥21,如上 述般’係配置於輸液容器1 0之插入口 3 〇的更内部側。此回 流阻止閥2 1 ’係用以關閉混注處理用開口構件2 〇之藥液的 流通者,於自插入口 3 0側承受到流體壓ρ時可讓藥液流通 者。 本發明之混注處理用開口構件2 〇的剖視構造如圖2所 示。圖2為對於回流阻止閥2 1的閥體23未施加來自插入口 3 0側之流體壓ρ的狀態,顯示該回流阻止閥2丨為使混注處 理用開口構件2 〇之藥液的流通關閉之狀態。對回流阻止閥 21施加來自插入口 30側之流體壓ρ,使混注處理用開口構 件2 0之藥液為可流通之狀態(亦即為使用狀態)的剖視構 造,係如圖3 (a )、( b)所示般。又,圖2及圖3為後述之圖 4(a)、(b)的a-A線剖視圖。 圖^及圖3所示之回流阻止閥21,具備有與插入口 30連通 之圓筒體22及由彈性體所構成之閥體23。 ^體Μ ’將配置於圓筒體22的内部以關閉藥液的流通, 於受到來自插入口 30側的流體壓ρ時,容易發生壓縮變 形’在與閥座2 4之間形成藥液流入用的空隙部2 6。此閥體 23 ’經由自輪液容器丨〇的内部側連。接到該閥體23之繫止部 2 7 ’可限制藥液之往該内部側的移動。 間座24 ’係自插入口 30側連接到閥體23者。閥座24具備\\ 326 \ 2cl- \ 91-09 \ 91113614.ptd Page 9 542731 V. Description of the invention (7) Infusion. Thereby, it is possible to avoid the Mailer reaction (M a 1 1 a r d r e a c t i ο η) via sugar and amino acid and the aggregation of the fat emulsion due to the electrolyte. (Backflow prevention valve) As described above, the backflow prevention valve 21 of the opening member 20 for infusion processing of the present invention is disposed on the inner side of the insertion port 3o of the infusion container 10. This backflow prevention valve 2 1 ′ is a circulator for closing the chemical liquid of the opening processing member 20 for mixing processing, and allows the liquid to circulate when the fluid pressure ρ is received from the insertion port 30 side. The cross-sectional structure of the opening member 20 for mixed injection processing of the present invention is shown in FIG. 2. FIG. 2 shows a state in which the fluid pressure ρ from the insertion port 30 side is not applied to the valve body 23 of the backflow prevention valve 21, and the backflow prevention valve 2 is shown to close the flow of the chemical solution of the opening member 2 for mixing processing. Of the state. A cross-sectional structure of a state in which the liquid pressure ρ from the insertion port 30 side is applied to the backflow prevention valve 21 so that the medicinal liquid of the mixing processing opening member 20 can be circulated (that is, used) is shown in FIG. 3 (a ), (B). 2 and 3 are cross-sectional views taken along line a-A of FIGS. 4 (a) and (b) described later. The backflow prevention valve 21 shown in Figs. 2 and 3 includes a cylindrical body 22 communicating with the insertion port 30 and a valve body 23 made of an elastic body.体 体 M 'It will be placed inside the cylindrical body 22 to close the flow of the medicinal solution. When the fluid pressure ρ from the insertion port 30 side is received, compression deformation is likely to occur.' The medicinal solution flows into the valve seat 24 Used gap section 2 6. This valve body 23 'is connected via the inner side of the wheel fluid container. A stopper 2 7 'connected to the valve body 23 can restrict the movement of the medicinal solution toward the inner side. The spacer 24 'is connected to the valve body 23 from the insertion port 30 side. Valve seat 24
第10頁 542731Page 542731
有藥液流通孔25,此藥液流通孔25,其閥體23於未 自插入口 30側之流體壓p之時,係經由閥體23而關閉,文來 一方面,若承受到來自插入口 3〇側之流體壓p則 ^ 狀態而與上述的空隙部2 6相連通。 …汗 閥體23與閥座24,係以使對該閥體23施加流體壓p之方 向與空隙部2 6之藥液之流動方向(圖3 (b)中箭頭所示之方 向)交叉的方式而配置。There is a medicinal fluid flow hole 25, and the medicinal fluid flow hole 25 has a valve body 23 that is closed by the valve body 23 when the fluid pressure p from the side of the insertion port 30 is not. The fluid pressure p on the port 30 side is in a state of ^ and communicates with the above-mentioned void portion 26. … The sweat valve body 23 and the valve seat 24 are such that the direction in which the fluid pressure p is applied to the valve body 23 intersects the flow direction of the medicinal liquid in the gap portion 26 (the direction indicated by the arrow in FIG. 3 (b)). Way to configure.
此閥體23,因於壓縮變形會成為如圖3(a)、(b)所示之 狀態。亦即,經由伴隨著來自插入口 3〇側的流體壓p的負 荷所致之閥體23的壓縮變形,於閥體23與閥座24之間形成 空隙部2 6,通過藥液流通孔2 5與空隙部2 6,使得混注液等 的流入成為可能。若終止對於閥體2 3的流體壓p的負荷, 則閥體23會回復到原來的狀態(亦即圖2所示之狀態),於 空隙部2 6、/肖失之同時,藥液流通孔2 5經由閥體2 3而關閉。 於閥體2 3之流體壓p的方向,係與閥體2 3於壓縮變形時 的動作的方向一致,且與閥體23之回復時的動作方向在同 軸(軸方向X )上。相對於此,藥液流入經由壓縮變形所產 生之空隙部26的方向y,並非與流體壓P施加於閥體23之方The valve body 23 is in a state shown in Figs. 3 (a) and 3 (b) due to compression deformation. That is, through the compression deformation of the valve body 23 due to the load due to the fluid pressure p from the side of the insertion port 30, a gap portion 26 is formed between the valve body 23 and the valve seat 24, and passes through the medicinal fluid flow hole 2 5 and the void portion 2 6 enable the inflow of the mixed liquid and the like. When the load on the fluid pressure p of the valve body 23 is terminated, the valve body 23 will return to the original state (that is, the state shown in FIG. 2), and at the same time when the gap portion 26 and / or are lost, the liquid medicine will circulate. The hole 25 is closed via the valve body 23. The direction of the fluid pressure p in the valve body 23 is the same as the movement direction of the valve body 23 during compression deformation, and is on the same axis (axis direction X) as the movement direction of the valve body 23 when it returns. On the other hand, the direction y in which the medicinal solution flows into the void portion 26 generated by the compression deformation is not the direction in which the fluid pressure P is applied to the valve body 23.
向在同軸上,而互相交叉著(以垂直相交為佳)(參照圖 3b)。 ’ 因此之故’可以解決隨著閥體之回復到原來的形狀(位 置)之復原動作所產生之藥液等之流體逆流之習用回流阻 止閥中之顯著的問題。又,只要沒有來自混注處理用開口 部1 2的流體壓之負荷,該開口部丨2之藥液的流通會被關Orientation is on the same axis and cross each other (preferably perpendicular intersection) (refer to Figure 3b). ‘So the reason’ can solve the significant problem in the conventional backflow prevention valve for the backflow of fluids such as medicinal liquid and the like generated when the valve body returns to its original shape (position). In addition, as long as there is no load of the fluid pressure from the opening portion 12 for mixing processing, the circulation of the chemical liquid in the opening portion 2 is closed.
91113614.ptd 第11頁 542731 五、發明說明(9) 閉,因此,於混注處理時及混注處理後之藥液的漏出可得 以防止。 (閥體) 作為用以形成回流阻止閥2 1的閥體2 3之彈性體,要求須 為:於經由例如注射器的活塞之擠壓等所產生之混注液的 流體壓P而可容易變形程度般地柔軟,且,於未負荷流體 壓P的狀態下須可維持其形狀者(例如顯示出作為膠體的性 狀者)。 作為此彈性體,具體而言,可列舉例如:天然橡膠、矽 橡膠、異戊丙烯橡膠等之橡膠;聚乙烯、聚丙烯等之塑 膠;各種熱塑性彈性體;之類的彈性體構件中之硬度充分 地低,充分地顯示有作為膠體的性狀者。其中尤以熱塑性 彈性體為較佳者。 作為上述熱塑性彈性體,更詳細而言,可列舉例如:苯 乙烯-乙稀/ 丁烯-苯乙烯叙段共聚物(SEBS)、苯乙稀-丁二 烯-苯乙烯嵌段共聚物(SBS)、苯乙烯-異戊丙烯-苯乙烯嵌 段共聚物(S I S )、順式丁烯二酸改質等之改質SEBS、苯乙 烯-乙烯/丙烯-苯乙烯嵌段共聚物(SEPS)、苯乙烯-乙烯/ 丁烯嵌段共聚物(SEB)、苯乙烯-乙烯/丙烯嵌段共聚物 (SEP)等之苯乙烯矽彈性體;乙烯-丙烯嵌段共聚物等之烯 烴系彈性體;聚氨基甲酸乙酯系彈性體等;及此等的混合 物。 閥體23的大小並無特別限定,以依於圓筒體22的内徑等 適宜地設定。又,閥體2 3若太大,則壓縮時的鼓起會太大91113614.ptd Page 11 542731 V. Description of the invention (9) Closed, therefore, leakage of the medicinal solution during and after the infusion treatment can be prevented. (Valve Body) As an elastic body for forming the valve body 23 of the backflow prevention valve 21, it is required that the elastic body can be easily deformed at the fluid pressure P of the mixed liquid generated by, for example, pressing of a piston of a syringe. It is generally soft, and it must be able to maintain its shape (for example, a person showing a colloidal property) in a state where the fluid pressure P is not loaded. Specific examples of this elastomer include rubbers such as natural rubber, silicone rubber, and isoprene rubber; plastics such as polyethylene and polypropylene; various thermoplastic elastomers; and hardness in elastomer members such as Those who are sufficiently low and sufficiently show the properties as colloids. Among them, a thermoplastic elastomer is particularly preferable. Specific examples of the thermoplastic elastomer include styrene-ethylene / butene-styrene segmented copolymer (SEBS) and styrene-butadiene-styrene block copolymer (SBS). ), Styrene-isoprene-styrene block copolymer (SIS), modified SEBS such as cis-butenedioic acid, styrene-ethylene / propylene-styrene block copolymer (SEPS), Styrene-silicon elastomers such as styrene-ethylene / butene block copolymers (SEB), styrene-ethylene / propylene block copolymers (SEP); olefin-based elastomers such as ethylene-propylene block copolymers; Polyurethane-based elastomers and the like; and mixtures of these. The size of the valve body 23 is not particularly limited, and is appropriately set depending on the inner diameter of the cylindrical body 22 and the like. Also, if the valve body 2 3 is too large, the bulging during compression will be too large.
\\326\2cl-\91-09\91113614.ptcl 第12頁 542731\\ 326 \ 2cl- \ 91-09 \ 91113614.ptcl Page 12 542731
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矽-聚氨基甲 j (Chem i tech 作為此種材料的具體例,可舉出對市售的 酸乙S旨系的膠體之商品名為rChemitch^el 公司製)適宜地添加常用的添加劑者。 (開口構件) 本發明之混注處理用開口構件2〇,可由下述之各種塑膠 來製作。其為例如:聚乙烯、聚丙烯、聚4 —曱基戊烯[例 如二三井=學(股)的商品名「TPX」]等之聚烯烴;乙烯一 四環十二烯共聚物[三井化學(股)的商品名「A P L·」]等之 聚環狀烯烴;丙烯〈腈> —丁二烯-苯乙烯共聚物(ABS);聚Silicon-polyurethane j (Chem i tech is a specific example of such a material, and a commercially available acetic acid-based colloid with a trade name of rChemitch ^ el) may be appropriately added. (Opening member) The opening member 20 for co-injection processing of the present invention can be made of various plastics described below. It is, for example, polyolefins such as polyethylene, polypropylene, poly 4-fluorenyl pentene [eg, Mitsui = academic (stock) trade name "TPX"], etc .; ethylene-tetracyclododecene copolymer [Mitsui Polycyclic olefins such as chemical (stock) under the trade name "APL ·"]; propylene <nitrile> —butadiene-styrene copolymer (ABS); poly
乙撐〈萘〉SI(PEN)(poly ethylene naphthalate)、聚對苯 二曱酸乙二醇酯(PET)、聚烯丙酯等之聚酯;聚二苯硫醚 (PPS)等之苯系聚合物等。 混注處理用開口構件2 〇,可經由下述的方法製造。其為 例如,將用以載置過滤器4 1之基座部分4 〇以射出成形、擠 壓成形等方法成形,將此基座部分4 〇,與預先以射出成 形、擠壓成形等的方法形成之含有圓筒體2 2及插入口 3 0的 構件加以組合,將雙方以熱炫接、超音波炫接、欲合、組 裝等的方法,加以固定黏合。Polyesters such as ethylene (naphthalene) SI (PEN) (poly ethylene naphthalate), polyethylene terephthalate (PET), polyallyl ester, etc .; benzene series such as polydiphenylsulfide (PPS) Polymer, etc. The opening member 20 for coinjection processing can be manufactured by the following method. For example, the base portion 40 for placing the filter 41 is formed by injection molding or extrusion molding, and the base portion 40 is formed by injection molding or extrusion molding in advance. The formed components including the cylindrical body 22 and the insertion opening 30 are combined, and the two sides are fixed and bonded by a method such as thermal connection, ultrasonic connection, aspiration, assembly, and the like.
閥體23,於配置到預先成形之基座部分40之後,再將含 有圓筒體2 2與插入口 3 0之構件加以組合即可。 (插入口) 呈大致圓筒狀的插入口 3 0,係為用以將混注用的藥液等 注入之注入具等插入、固定之部位。 於插入口 3 0的外周面,並無特別限定之物以設置突起物After the valve body 23 is disposed on the pre-formed base portion 40, a member including the cylindrical body 22 and the insertion port 30 may be combined. (Insertion port) The insertion port 30 having a substantially cylindrical shape is a part to be inserted and fixed by an injection device or the like for injecting a liquid medicine for mixing. There are no special restrictions on the outer peripheral surface of the insertion port 30 to provide protrusions.
542731 五、發明說明(12) γ或螺紋為佳。此情況下,可將例如具備有内螺紋之外筒 部與具備有嵌插用的内筒部之所謂的吸引—鎖緊型注入具 (未圖示)固定於插入口 30,可作成混注作業的操作性良好 者。 (過濾器) 本發明之混注處理用開口構件2〇之過濾器41,可採用與 方;3知的輸液管路之過濾器(亦即,組裝於輸液套組者 相同者。作為此過濾器之具體例,可列舉例如使用聚乙 烯、、聚丙烯、聚酯、聚醯胺(尼龍)等之樹脂所構的 _ 過濾器,及使用上述樹脂的纖維之不織布所膜' 過濾器等。 丹取的十膜型 過濾器的孔徑,就達成阻止雜物及細菌等 τ心通過’且蚀 匕注液可順利地流入的觀點考量,宜設定為〇 1 而以設定為0· 1〜0.3 /zm為佳。該孔徑,^叶二10 , 〇.旧.25,為佳,而以〇.2心程度為更佳^圍中尤以 過滤器’只要是在混注處理用開口構件内 並無特別限定。因而,可配置於輸液容器内之=:二位置 閥更内部側,亦可配置於較外部侧。 I回Μ阻止 (基座部分) 於圖2及圖3所示之混注處理用開口構 為用以载置過濾器41的基座及作為中,使用著作 座部分40(參照圖4 (b))。又,Η、“ 勺固定部27之基 仰視圖。 圖4(b)為該開口構件20的 此基座部分40,於載置著過濾器41 且具備有用以使通542731 V. Description of the invention (12) γ or thread is preferred. In this case, a so-called suction-locking type injection tool (not shown) provided with an external cylindrical portion having an internal thread and an internal cylindrical portion for inserting can be fixed to the insertion port 30, for example. Those with good operability. (Filter) As the filter 41 of the opening member 20 for mixed injection processing of the present invention, a filter of the infusion line (that is, the same as the one assembled in the infusion set) can be used. As this filter Specific examples include a filter made of a resin such as polyethylene, polypropylene, polyester, polyamide (nylon), and a filter made of a non-woven fabric made of fibers of the resin. The pore diameter of the ten-membrane filter is taken to achieve the viewpoint of preventing debris and bacteria from passing through, and the erosion solution can flow in smoothly. It should be set to 〇1 and set to 0 · 1 ~ 0.3 / zm is better. The pore diameter, 二 2, 10, 旧 .25, is better, and 0.2 degree is more preferable. ^ In particular, the filter is used as long as it is in the opening member for mixing processing. Specially limited. Therefore, the two-position valve that can be placed in the infusion container can be placed on the inner side or on the outer side. I-M block (base part) is used for the infusion processing shown in Figure 2 and Figure 3. The opening is configured as a base on which the filter 41 is placed, and a writing base is used as the base. 40 (refer to FIG. 4 (b)). In addition, a bottom view of the base of the scoop fixing portion 27. FIG. 4 (b) is the base portion 40 of the opening member 20. Useful for communication
91113614.ptd 第15頁 542731 五、發明說明(13) 過該過濾器4 1之藥液流入輸液容器丨〇内之流通路42 (參照 圖4 (b)及圖5 )。又’圖5為顯示圖2所示之混注處理用開口 構件2 0之中的只有基座部分4 〇的俯視圖。 通過閥體23與閥座24之間(空隙部份26)的混注液,流經 過渡器41與圓筒體22之間的流通路28,藉由通過過濾器41 後再通過設置於基座部分40之流通路42,流入輸液容器1〇 的容納室1 4 (於圖1所示輸液容器丨〇之情況為下部容納室 1 4b )中。 、於基座部分40的表面,以經由例如設置多數的凸部43與 ,槽部44來形成凹凸為佳(參照圖2、圖3及圖5)。藉此,〃 U可較容易通過過濾器41内’而可提高藥液的混; 的操作性。 (蓋子) 於插入口30的前端部分,於迄至使用輸液容器"之前 以昆注處理之前),必須要防止雜物及細菌的混入, 认置可卸下之密封機構來密封,例如裝 可剝離式密封膜來保護為佳。 I子35或以 圖1 、圖2及圖4(a)中所干夕f子,由於技^ 螺纹38去从叮诉人所 I 由於係於内部具有内 31、而螺合於設置於插人U3G的外周面之突起物 的俯ί圖又,圖4U)為圖之混注處理用開口構件 (輪液谷為本體及排出處理用開口部) ::發明之輸液容器]"’作成為輸液容器的本體之容 ,及排出處理用開口部丨丨,並無特別限定,可採用91113614.ptd Page 15 542731 V. Description of the invention (13) The medicinal solution passing through the filter 41 flows into the inflow container 42 in the infusion container (see FIG. 4 (b) and FIG. 5). FIG. 5 is a plan view showing only the base portion 40 among the opening members 20 for mixed injection processing shown in FIG. 2. The mixed liquid between the valve body 23 and the valve seat 24 (the gap portion 26) flows through the flow path 28 between the transition device 41 and the cylindrical body 22, passes through the filter 41, and then passes through the installation base. The flow path 42 of the portion 40 flows into the storage chamber 14 of the infusion container 10 (in the case of the infusion container 10 shown in FIG. 1, the lower storage chamber 14b). On the surface of the base portion 40, for example, it is preferable to form a plurality of convex portions 43 and groove portions 44 to form irregularities (see FIGS. 2, 3, and 5). With this, 〃U can pass through the filter 41 more easily, and the operability of the medicinal solution can be improved. (Cover) At the front end of the insertion port 30, and before the infusion container is used (previously treated with Kun injection), it is necessary to prevent the contamination of debris and bacteria. A removable sealing mechanism is required to seal it. Peelable sealing film is better for protection. I sub-35 or the sub-sequence as shown in Figures 1, 2 and 4 (a), because the technology 38 thread to go from the whistleblower I because it is tied to the inside with 31, and screwed to the plug The top view of the protrusion on the outer surface of the human U3G, and FIG. 4U) is the opening member for injection processing (the liquid valley is the main body and the opening for discharge processing) :: Infusion container of the invention] " '作成The content of the body of the infusion container and the opening for discharge processing are not particularly limited, and may be used
542731 五、發明說明(14) 習知者。 以上,係就本發明之混注處理用開口部及使用其之輸液 _ 容器做了詳述,惟,本發明並非限定於上述者(特別是記 載於圖1〜圖5中者),在不變更本發明之精神的範圍内加以 _ 適當的設計變更而實施係為可能,皆屬本發明之範疇。 產業上之可利用性 本發明之混注處理用開口構件2 0及使用其之輸液容器, 於進行往輸液容器内之藥液等之混注處理時,不會有雜物 及細菌等混入的顧慮,且於混注處理之後,由於可確保輸 ’ 液容器的密封性,故於醫療用方面之實用上可有利地加以 丨·-使用。 元件編號說明 10 羊刖 液 容 器 11 排 出 處 理 用 開 Ό 部 12 混 注 處 理 用 開 V 部 13 間 隔 壁 14 容 納 室 14a 上 部 容 納 室 14b 下 部 容 納 室 20 混 注 處 理 用 開 Ό 構件 21 回 流 阻 止 閥 22 圓 筒 體 23 閥 體 24 閥 座542731 V. Description of the invention (14) Learners. In the above, the opening portion for co-injection processing and the infusion container using the same according to the present invention have been described in detail, but the present invention is not limited to the above (especially those described in FIGS. 1 to 5), and will not be changed. Appropriate design changes and implementation within the scope of the spirit of the present invention are possible, and all belong to the scope of the present invention. INDUSTRIAL APPLICABILITY The opening member 20 for infusion processing of the present invention and the infusion container using the same are free from contamination of foreign matter and bacteria during the infusion treatment of a medicinal solution into the infusion container. And after the co-injection treatment, since the tightness of the infusion container can be ensured, it can be advantageously used in medical applications. Description of Part Numbers 10 Sheep liquid container 11 Opening section for discharge processing 12 Opening section for mixing processing 13 Partition wall 14 Storage chamber 14a Upper storage chamber 14b Lower storage chamber 20 Opening chamber for mixing processing Member 21 Backflow prevention valve 22 Cylinder Body 23 valve body 24 valve seat
91113614.ptd 第17頁 542731 五、發明說明(15) 25 藥液流通孔 26 空隙部 27 繫止部 28 流通路 30 插入口 31 突起物 35 蓋子 38 内螺紋 40 基座部分 41 過濾器 42 流通路 43 凸部 44 溝槽部 P 流體壓91113614.ptd Page 17 542731 V. Description of the invention (15) 25 Chemical solution flow hole 26 Gap portion 27 Fastening portion 28 Flow path 30 Insertion port 31 Protrusion 35 Cover 38 Internal thread 40 Base part 41 Filter 42 Flow path 43 convex portion 44 groove portion P fluid pressure
91113614.ptd 第18頁 542731 圖式簡單說明 圖1為顯示本發明之輸液容器的一個實施形態之前視 圖2為顯示本發明之混注處理用開口構件的一個實施形 態之剖視圖。 圖3 ( a )為顯示圖2中所示之混注處理用開口構件2 0的使 用狀態之剖視圖;(b)為(a)的部分放大圖。 圖4(a)為圖2所之混注處理用開口構件20的前視圖’ (b )為仰視圖。 圖5為圖2所示之混注處理用開口構件2 0中之基座部分4 0 的俯視圖。91113614.ptd Page 18 542731 Brief description of the drawings Fig. 1 is a front view showing an embodiment of the infusion container of the present invention. Fig. 2 is a cross-sectional view showing an embodiment of the opening member for mixed injection processing of the present invention. Fig. 3 (a) is a sectional view showing a use state of the opening member 20 for coinjection processing shown in Fig. 2; (b) is a partially enlarged view of (a). Fig. 4 (a) is a front view '(b) of the mixed injection processing opening member 20 shown in Fig. 2 is a bottom view. FIG. 5 is a plan view of the base portion 40 of the opening member 20 for the mixed injection processing shown in FIG. 2.
91113614.ptd 第19頁91113614.ptd Page 19
Claims (1)
Applications Claiming Priority (1)
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JP2001189743 | 2001-06-22 |
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TW542731B true TW542731B (en) | 2003-07-21 |
Family
ID=19028620
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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TW91113614A TW542731B (en) | 2001-06-22 | 2002-06-21 | Mouth member for mixed filling processing and infusion container using the mouth member |
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JP (1) | JPWO2003000170A1 (en) |
TW (1) | TW542731B (en) |
WO (1) | WO2003000170A1 (en) |
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EP1943762B1 (en) | 2005-11-04 | 2014-07-23 | TELEFONAKTIEBOLAGET LM ERICSSON (publ) | Method and transmission unit for adaptive coding, modulation and transmittion of data words in a wireless communication system |
WO2008036101A2 (en) * | 2005-11-07 | 2008-03-27 | Industrie Borla S.P.A. | Vented safe handling vial adapter |
JP5426550B2 (en) * | 2008-07-09 | 2014-02-26 | テルモ株式会社 | Drug storage container |
DE102016110569B3 (en) | 2016-06-08 | 2017-10-26 | Sfm Medical Devices Gmbh | adapter |
US11224555B2 (en) | 2018-04-23 | 2022-01-18 | Hospira, Inc. | Access and vapor containment system for a drug vial and method of making and using same |
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JPH0510819Y2 (en) * | 1987-11-30 | 1993-03-17 | ||
JP3153687B2 (en) * | 1993-10-07 | 2001-04-09 | 旭化成株式会社 | Medical infusion plug with excellent heat resistance and recovery properties |
JP2002143270A (en) * | 2000-11-07 | 2002-05-21 | Asahi Kasei Corp | Plug body for infusion liquid container |
JP3820889B2 (en) * | 2001-02-05 | 2006-09-13 | ニプロ株式会社 | Infusion container |
-
2002
- 2002-06-19 JP JP2003506616A patent/JPWO2003000170A1/en not_active Withdrawn
- 2002-06-19 WO PCT/JP2002/006092 patent/WO2003000170A1/en active Application Filing
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JPWO2003000170A1 (en) | 2004-10-07 |
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