TW506839B - Germproof deodorizing deodorant spray composition - Google Patents

Abstract

This invention discloses a germproof deodorizing deodorant spray composition, which contains primarily a natural chitin or its derivatives as an effective ingredient, can rapidly adsorb and neutralize source of odor, provides a germproof deodorant protection layer, and can effectively counteract growth of bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa leading to decaying odor with a 99.95% effectiveness. Therefore, it can be applied extensively to various occasions requiring deodorizing/deodorant, germproof and aromatic function, such as a place with smoke smell, a carpet in vehicle, a trunk, a bathroom, a toilet, a pet house, a sink in kitchen, a place with accumulated garbage and a space filled with oily smoke.

Description

506839 A7 _____. B7 V. Description of the invention (1) Background of the invention ------: ---------- equipment-(Please read the note on the back? Matters before filling out this page) • Line In view of the rapid industrial development in Taiwan in recent years, the improvement of material living standards has also increased the amount of industrial and livelihood waste disposal. However, most of the livelihood waste is currently disposed of in landfills, and the volatile emissions from landfill sites The odors of ammonia and hydrogen sulfide, and the smell of odorous water leaking from the decomposition of garbage, often cause air and water pollution, and cause resistance from nearby residents. Existing in the environment of daily life, smoke, kitchen and toilet odors, pet odors and other problems also cause people's physical and psychological discomfort. Odor is a chemical substance that is highly volatile (molecular weight less than 350) and is hydrophilic or lipophilic. The sources of odor are ammonia, sulfides, and volatile organic compounds. Although malodorous substances have not caused special causes to the human body, they can cause respiratory disorders, loss of appetite, vomiting, insomnia and general nervousness. In addition to the bacteria and mold that are generated in the pollution source, in addition to continuing to decompose the material to generate ammonia and odor sources, it also causes disease to the human body. Therefore, how to find effective deodorant / deodorant and antibacterial composition is a long-awaited goal for human life and industry. Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs Deodorization and deodorization are somewhat different in meaning. Deodorization refers to eliminating the odor that has occurred. Deodorization is to prevent bacteria from having a chance to reproduce and cause odor. Therefore, deodorization does not necessarily deodorize, and deodorization does not necessarily deodorize. Sensory deodorization methods that use odors and fragrances to remove odors only dilute and suppress odors, and do not completely absorb or decompose odor sources, so they can only cause short-term deodorization effects. Deodorization by chemical reaction methods, such as redox reaction, acid-base / electric neutralization reaction, addition / concentration reaction, etc., requires the use of a large number of chemical agents to participate in the reaction, which is another type of pollution to the environment and organisms. Use activated carbon, silicon rubber, 4 paper sizes applicable to Chinese National Standard (CNS) A4 specifications (210 X 297 mm) 506839 A7 B7 Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 5. Description of the invention (2) Aluminum glue, active The physical adsorption of clay, zeolite, and other adsorbents with high specific surface area on porous materials mainly uses the van der Waals force between the deodorant and the odor molecules to bind the odor components so that they cannot spread to Air to reduce odor. However, this is a kind of equilibrium reaction. When the adsorption reaches saturation or temperature changes, the odor components will be released, and the general use type is easily restricted by the solid adsorbent, which is not conducive to large-scale treatment. The use of specific bacteria to transform and decompose odor molecules, although the effect is the best, is limited by the culture and purification of bacteria, and the cost of fungus preservation is high. Detailed description of the invention Chitin and chitosan are natural non-toxic polymers with biodegradability. Its structure is similar to that of cellulose. It consists of 1000-3000 N-acetylglucosamines. (N-ACETYL—2 AMIN0-2 DEOXY-dD-GLUCOSE or n-ACETYL-d-GLUC〇SAMINE) Linear polymer saccharides composed of / 3 -1,4 bonds (the structural formulas are respectively As follows). In nature, chitin is the most abundant glycosaminoglycan-type polysaccharide on earth, second only to cellulose. It is mainly found in the shells of invertebrates such as insects and aquatic crustaceans, and the cell walls of fungi. Its role in the organism is mainly used as the body skeleton and protection. Chitosan is a product of chitin deacetylation. Generally, the degree of chitin deacetylation is more than 70%, and it can be turned into an acid-soluble chitosan product. 5 This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) (Please read the note on the back 3 before filling this page)

'n n n «κι ϋ« I 1 One: ^ · _1 n ϋ 1 «ϋ I I A · 506839 A7 B7 V. Description of the invention (3) αι > 〇Η

Η OH

OH

(M'jm i too. N OH

OH

ahOH CihOH

(Please read the notes on the back before filling this page) Chitin and chitosan printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs are good because they have hydroxyl groups, acetamido groups, and amine groups in the structure. Hydrophilic and lipophilic properties, coupled with the pores of the three-dimensional structure, so it has active sites for chemical and physical adsorption. It has been confirmed that chitosan / chitin is for heavy metals, dyes, proteins, enzymes, organic / Inorganic acids [Ivo Georgiev Lalov, Illia Illiev Guerginov, Milka Asenova Krysteva, and Kiril Fartsov. "Treatment of waste water from distilleries with chitosan", Wat. Res ·, Vol. 34, No. 5, pl503-1506, 2000 ·] , Ammonia gas [United States Patent Re. 35151], hydrogen sulfide [United States Patent Re · 35151], organic volatile substances (VOC, s) [Hyun-Mee Park, Young-Man Kim, Dai-Woon Lee, and Kang -Bong Lee. ^ Evaluation of natural crab shell as; installation ----------- order ---------- This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) ) 506839 A7 B7 V. Description of the invention (4) an adsorbe nt for preconcentrating airbone volitate organic compounds collected in a canister ", Journal of chromatography A, 829, p2 15-221, 1998.], sulfide [United States Patent 5932495], indole [United States Patent 5932495 ], Skatole [United States Patent 5932495], isovaleric acid [United States Patent 5932495], triethylamine [United States Patent 5932495], heavy oil [Leonardo Setti, Stefania Mazzieri, and Pier Giorgio Pifferi. ^ Enhanced degradation of heavy oil in an aqueous system by a Pseudomonas sp · in the presence of natural and synthetic sorbents' Bioresource Technology, Vol. 67, p 191 -199, 1 999.], methyl mercaptan ( methyl mercaptan) [United States Patent 45 12968], polychlorinated biphenyls ["Advances in chitin and chitosan", p639-647, 1-991, Jean-Pierre Thome, Jean-Louis Hugla, and Marek Weltrowski, "Affinity of chitosan and related / or], etc., has a good adsorption effect. In addition, its structure has multivalent cationic properties, so chitosan is more soluble than chitin, and therefore has higher antibacterial activity [Chee-Shan Chen, Wan-Yu Liau, and Guo-Jane Tsai. "Antibacterial Effects of N. Sulfonated and Nsulfobenzoyl Chitosan and Application to Oyster Preservation ", Journal of Food Protection, 61 (9), pll24-1 128, 1998.]. Factors affecting the antibacterial activity of chitosan, including deacetylation degree, age, temperature, molecular weight (low molecular weight chitosan is better than high molecular weight chitosan against pathogenic bacteria) and 7 This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) (Please read the precautions on the back before filling this page)

nn 0Mmm§ β · — nt one one 0, > mMmmm mmi ί ϋ ni ···· n I Printed by A7 B7, Consumer Cooperative of Intellectual Property Bureau of the Ministry of Economic Affairs 5. Description of Invention (5) • ----_- ------ 11 --- (Please read the precautions on the back of this page, and then go to this page.) PH 印 printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs (but acid-base 値 is not antibacterial when it is 7.0, The reason is that the amine group of chitosan does not have a positive charge in a neutral environment and has poor solubility). The bacteriostatic mechanism is based on two possible reasons in the literature: (1) The positive charge of chitosan combined with the negatively charged substance on the surface of the bacteria causes the pores to penetrate the body, and the contents such as glucose and protein flow out and die. (2) Because of the positive charge of chitosan, the bacteria with negatively charged molecules on the surface attract each other by electrostatic interaction and attach. According to literature research, high concentration of chitosan (1 ~ 1.5%) was added to the culture medium, and the pH was adjusted to 5.5 or 6.5 with 2% acetic acid. Two days after inoculation, it was able to treat Staphylococcus aureus. Produces a complete antibacterial effect [Wang, GH, “Inhibition and inactivation of five species of foodborne pathogens by chitosan”, J. Food Prot. Vol. 55, p916-919, 1992.]. For E. coli, the minimum inhibitory concentration of chitosan for bacteriostatic effect is 0.0075%, [Simpson, B. K ·, Gagne, N ·, Ashie, INA, and Noroozi, E ·, "Utilization of chitosan for preservation of ra w shrimp (Pandalus borealis) 'Food biotechnol., 11 (1) p25-44, 1997.]. Therefore, chitosan can be used as a deodorant and antibacterial fiber in clothes, bedding, home furnishings, and medical equipment. For example, KURABYON of Japan's Omikesi Company, CHITOPOLY of Fuji Spinning 'Kidomoto KIDO · KORA, BESCHITIN of Unitika, etc. It is used in oral health foods for antibacterial and deodorization, such as gelatin toothpaste and liquid from Lion Company Toothpaste, tooth powder, mouthwash, chewing gum, liquid oral cooling agent, solid oral cooling agent, etc. Taiwan's aquaculture industry is developed, but in addition to food, some of the aquatic resources are processed into feed for reuse, and the rest are discarded. Discard the material if it can be used. 8 This paper size applies the Chinese National Standard (CNS) A4 (210 X 297 mm) 506839

Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs. 5. Description of the invention (6) Use this waste to develop this material into consumer products for antibacterial and deodorant composition, or use it in industry, such as waste water, garbage and sewage odor treatment. Waiting, not only solve the problem of garbage, but also create another business opportunity. The invention first discloses an antibacterial, deodorizing and deodorizing spray composition comprising a chitin or a chitin derivative as an active ingredient of antibacterial, deodorizing and deodorizing; an acid, wherein the acid The weight ratio is between 50: 1 to 1:50; and water, so it is suitable to use a sprayer to spray directly on the odor / bacteria source, which can conveniently, efficiently and environmentally friendly achieve antibacterial, sterilizing and deodorizing functions. The polymer long chain of the composition of the present invention combined with a chitin derivative has a hydrophilic, lipophilic and porous physical adsorption capacity and a chemical neutralization characteristic with a cationic functional group in the structure, plus the positive and negative attraction neutralization capabilities of the organic acid. To achieve the deodorizing effect; and to use the unique positively charged properties of chitin and its derivatives to achieve antibacterial and deodorizing effects, and to provide an antibacterial protective layer; add fragrance to generate aromatic odors and reduce the discomfort caused by the initial odor , Really achieve the functions of Fangxiang, Fjiu, deodorizing / deodorizing β. Preferably, the composition of the present invention further comprises a fragrance, wherein the weight ratio of the fragrance to the active ingredient is between 10: 1 and 1:50. When the perfume is in an oily phase, the composition of the present invention preferably further comprises an emulsifier having an HLB 値 between 1 and 20 to form an emulsion with the composition. More preferably, the composition of the present invention contains 0.01% to 1.0% of perfume and 0.01% to 1.0% of emulsifier, based on the weight of the composition. Preferably, the emulsifier is non-ionic and has HLB (R) of 15-18. :: Better-of, the chitin and chitin derivatives in the composition of the present invention 9 The paper size is applicable to China National Standard (CNS) A4 (210 X 297 mm) (Please read the note on the back first (Fill in this page again)

-1 ^ 1 1 n ϋ · ^^ V n ϋ 0Mmm ϋ I 1 I A7

V. Description of the invention (7) (Amended in January 2002) 506839 /, has a molecular weight of ~ 1 between 10,000 and 500,000. More preferably, the chitin derivative is chitosan. Preferably, the active ingredient in the composition of the present invention is deacetylated chitosan with a content of 70-100%. Preferably, the composition of the present invention contains 0.001% to 5.0%, more preferably 0.05% to 1.0%, and the deacetylated polybutylene polymer having a concentration between 70 and 100%. sugar. The acid in the composition of the present invention is preferably selected from the group consisting of formic acid, acetic acid, lactic acid, citric acid, tartaric acid, and succini, c acid), malic acid, oxalic acid, glycolic acid, dichloroacetic acid, trifluoroacetic acid, tannic acid Ethnic group. Acetic acid is more preferred. Experimental content (in this experiment, unless otherwise stated, all% are based on the weight of the composition) Deodorization test method (1) This test method refers to US Reapproved Patent No. 35151 (United States

States Patent Re. 35151) simple deodorization experiment method and make some modifications, the steps are as follows: take 0.5 ml 29.2% ammonium hydroxide dropwise into 1000 ml water to configure 148 ppm ammonia solution. Take 5 ml of the above solution and drop it into a petri dish placed in a drying box. One group is not sprayed with any substance (No. origin). After measuring the time, measure the ammonia concentration in the drying box as the initial ammonia concentration before deodorization. The experimental group sprayed / covered 1 ml with deodorant (as shown in Table 1), each at 30 1 10 This paper size is applicable to China National Standard (CNS) A4 (210 X 297 mm) (Please read the notes on the back first (Fill in this page again) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs

506839 A7 B7 (Amended in January 2002) 5. Description of the invention (8) Minutes in the dry box with ACCURO 2000 gas detector, number 8 丨 01941 ammonia gas detection tube (detection range 5-100 ppm) The results of ammonia concentration are shown in Table 2 (please read the precautions on the back before filling this page). _ Table 1. Ingredients of Fort Odor ________ No. Chitosan * Content i Acid content A 1.00% 0.2500% B 0.50% 0.1250% C 0.10% 0.0250% D 0.20% 0.0500% Fragrance and emulsifier E 0.10% 0.0250% Fragrance and Emulsifier F 0.05% 0.0125% Fragrance and Emulsifier G 100% — Chitin in powder form 0.1 g Η 100% — Chitin in sheet form 0.5 g I 100% — Chitin in granular form 2 g : Chitosan source is Kaidesheng Technology, its molecular weight is about 300,000, deacetylation is 93%, fragrance is orchid essential oil ^, content is 0.05%: emulsifier is HLB16.7, Trade name Tween-20, content of 0.05%. Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs. Table 2. Deodorization results of deodorization test (1) _ # Ammonia concentration (ppm) reduction * (%) Unused 80 00.00 A 5 93.75 B 15 81.25 11 This paper size applies to Chinese National Standard (CNS) A4 (210 X 297 mm) 506839 A7 B7 Five (Amended in January 2002) C 20 75.00 D 5 93.75 E 5 93.75 F 5 93.75 G 5 93.75 Η 5 93.75 I 5 93.75 Decrease (%) = <(Ammonia gas concentration after 30 minutes Concentration) / Initial concentration of ammonia> x100% Deodorization test method (II) Use Whatman No. 1 filter paper with a diameter of 9 cm to absorb cigarette smoke. Both sides of the sheet are sprayed with the fragrance-free deodorant C 0.5 of the present invention. ml, the second one was sprayed with the perfumed deodorant E 0.5 ml on both the front and the back, the third one was not sprayed as a control group, and two were immediately given to the 10 test subjects for sensory sensation with the nose, and three evaluation standards were customized As shown in Table 3, and the experimental results shown in Table 4, there is a downward trend. (Please read the notes on the back before filling out this page) Printed by the Employees' Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs. 3. Smoke score 1 vote. Quasi-sensory evaluation * Score feels strong smoke 5 Feels slight smoke 3 Feels smokeless 1 * Compared with the control group, 12 paper sizes are applicable to Chinese National Standard (CNS) A4 (210 X 297 mm) 506839 Α7 Β7 V. Description of the invention (10 (2002 1

Yuexiu A Table IV. Deodorization results (deodorization results test subject A, B, C, D, P, E, H, G, and G. Xin) Rating (1): Rating (2):

* Spray with deodorant No. E in Table 1〃 Spray deodorant with No. C in Table 1 (3) Take wood chips (containing strong offensive odor in excrement) spread in golden rat and guinea pig cages ) 2 g in a petri dish, put / spray 1 ml of A, D, G, Η, I deodorant in Table 1, respectively, cover the petri dish cover (control group contains odor wood chips only), in 1 Hours after opening the petri dish lid for sensory sensation 'Compared with the control group deodorant number ADG Η I Evaluation * ― — ― — —— ------------- Read the attention on the back first Please fill in this page again for details) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs * Compared with the control group, those with significantly lower odors will be marked with "-". Deodorizing experiment method (4) Put / spray A, D, G, Η, I deodorant 1 ml in the trash bin with odor, and spray the liquid deodorant to the nose after 10 minutes The sensory sensation was performed, and the person who placed the solid deodorant performed sensory sensation with the nose after 1 hour, and as a result, the odor was reduced. Experiencing interest-experience (five _) _ Put / spray A, D, G, Η, 13 of seafood containing fishy odor separately. This paper size is applicable to China National Standard (CNS) A4 (210 X 297). 506839 (Amended in January 2002) 11 A7 B7 i. Description of the invention (I deodorant 1 ml, spraying liquid deodorant after 10 minutes with sensory sensation in the nose, and those who put solid deodorant at 1 Sensory sensation with the nose after an hour 'result reduced the odor. Antibacterial experiment experimental strains Pseudomonas areuginosa CCRC12450 and Staphylococcus aureus subsp. Aureus CCRC12657). Flask &quot; Proceed. First, culture the bacteria in 100ml nutrient medium (mitrientbmth, temperature 37 ° C, shaking at 120 rpm for 19 hours to activate the bacteria. Put 1ml of the activated bacteria into a 100ml serving?) (6.25 &lt; &lt; 1〇-4111〇 ^ / 10) in an Erlenmeyer flask at a temperature of 37 ° C and shaking at 120 ° C for 1 hour. Take 1 ml of this solution and drop it into 100 ml containing 0.6% acetic acid 10m KH2P. 4 In a solution of 90 ml and 0.1 g of the test substance. The solution was diluted 106 ~ 10i2 times, and Oi ml of each diluted solution was applied to a petri dish containing nutrient medium, put in an incubator (37 ° C), and cultured for 19 hours. The colonies were selected to be 25 ~ 250 The Petri dish was counted by a colony counter, and its bacterial count was expressed in CFU / ml. The results are shown in Table 5. Table V. Antibacterial test results (please read the precautions on the back before filling in this page)

Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs to print the test bacteria (CFU / ml) after treatment (CFU / ml) Bacteriostatic rate (%) Pseudomonas areuginosa 8 · 15χ 1011 2.5 χΙΟ7 99.99 Staphylococcus aureus subsp. aureus 2.62 &gt; αο6 1.2 Χίο3 99.95 14 This paper is in accordance with China National Standard (CNS) A4 (210 X 297 mm)

Claims (1)

506839 A8 B8 C8 D8 Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 6. Application for patent scope 1. An antibacterial, deodorant and deodorant spray composition containing a chitin or chitin as an effective antibacterial, deodorant and deodorant active ingredient Butyrin derivative; an acid, wherein the weight ratio of the acid to the active ingredient is between 50: 1 to 1:50; and water. 2. The composition according to item 1 of the patent application scope, further comprising a fragrance, wherein the weight ratio of the fragrance to the active ingredient is between 10: 1 and 1:50. 3. The composition according to item 2 of the scope of patent application, wherein when the perfume is in an oil phase, it further comprises an emulsifier having an HLB 値 between 1 and 20 to form an emulsion with the composition. 4. The composition of item 3 of the scope of patent application, which contains 0.01% to 1.0% of fragrance and 0.01% to 1.0% of emulsifier, based on the weight of the composition. 5. The composition as claimed in claim 1, wherein the chitin and the chitin derivative have a molecular weight between 10,000 and 500,000. 6. The composition according to item 1 of the patent application scope, wherein the chitin derivative is chitosan. 7. The composition according to item 1 of the patent application scope, wherein the active ingredient is chitosan with a deacetylation of 70-100%. 15 This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) (Please read the precautions on the back before filling this page)-------- Order i 506839 ABCD Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 6. Application for Patent Scope 8. If the composition of the scope of patent application item 7 contains 0.01% to 5.0% of the deacetylation of 70-100% Polybutan. 9. The composition according to item 8 of the patent application scope, which comprises 0.05% to 1.0% of the polybutan deacetylated between 70 and 100%. 10. The composition according to item 3 of the scope of patent application, wherein the emulsifier is non-ionic and has HLB (R) of 15-18. 11. The composition according to item 1 of the patent application scope, wherein the acid is selected from the group consisting of formic acid, aceticacid, lactic acid, citric acid, tartaric acid, and humic acid. Succinic acid, malic acid, oxalic acid, glycolic acid, dichloroacetic acid, trifluoroacetic acid, tannic acid Formed by the ethnic group. 12. If the composition in the scope of application for patent No. 11, where the acid is acetic acid 0 16 This paper size is applicable to China National Standard (CNS) A4 specifications (210 X 297 mm) &lt; Please read the precautions on the back before filling (This page) · i-line-螬