TW480157B - Smokable product - Google Patents

Abstract

The present invention relates to smokable products, such as filter cigarettes, filter cigarillos or filtered cigars, which comprise a filter which is active in the gas phase and/or cigarette paper which is active in the gas phase and/or one or more other components accessible to the main smoke stream with an addition of substances which are active in the gas phase, and which are provided with an addition of substances having an antioxidative action.

Description

5. Description of the invention ("Symmology refers to a smokeable product, such as filter cigarette, filter J, plus or filter cigar, which contains a filter which is active in the gas phase and / or cigarette paper which is in the gas The phase is active and / or one or more other components can be close to the main smoke stream to be added to the gas phase with active substances, and it is added with anti-oxidant substances. The system can be used to reduce smoking tobacco products The best known method is the so-called "light" or "ultra-light" cigarettes. The use of highly-retaining mouths combined with correspondingly matched filters and mouth ventilation can reduce the particle phase and so-called main smoke flow. The gas phase thus reduces the risk as a whole. The filter preparation system incorporates active substances such as activated carbon in the gas phase. It is further known that the gas phase of Xiaoxuesu or Xuesu is particularly reduced. These filter cigarettes are described in DE-PS 41 05 500 C1 or EP-PS 0 558 166 B1. DE-PS 44 16 101 C2 further reveals smokeable tobacco products, which contain natural antioxidants to reduce the possibility of mutations in tobacco leaf tobacco. Eight but so far the aforementioned solution It has not shown the undesired effect of reducing and selectively even replenishing the herbicide on the microcirculation damage of blood circulation. Blood is distributed in tiny blood vessels, that is, microcirculation is the most important functional part of blood circulation. Oxygen and nutrients between blood and tissue cells And the diffusion of metabolites is here to work. There is a wide difference between the microcirculation and macroscopic circulation of arteries and veins. · Small blood vessels (microvessels, arterioles, and venules) are separated from blood plasma more or less. Only after passing through the microcirculation network can they recombine in the vein. Microcirculation is adapted to the needs of specific tissues through a variety of regulators, and its function is determined by the nature and condition of blood flow. The distribution of blood cells in small blood vessels is adjacent to Tissue Cell Nutrition (Red Blood Cells) (Please read the note on the back? Matters before filling out this page) -------- ^ --------- ^ Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs 4 A7

480157 V. Description of the invention (2) and the immune response (white blood cells) are very important. During smoking, the microcirculation of the oral cavity (a representative organ region) and other organs or other organ regions changes temporarily. The oral mucosa first comes in contact with tobacco leaf tobacco and also other substances taken up through the respiratory or digestive tract. The oral cavity represents a particularly effective organ area that accepts and defends against environmental influences. During smoking and the next few minutes, the blood distribution of the small blood vessels here is slightly 5: restricting the blood flow intensity of the small blood vessels to decrease, increasing the number of white blood cells appearing in the corporate tube, and temporarily adhering to the blood vessel wall (causing an immune response). In healthy people, because the blood distribution and short-term restriction of blood flow caused by smoking can be compensated by the endogenous regulator, it is not particularly unacceptable. In the “normal” mother's day life, the microcirculation is occasionally affected by significant changes. The effects of smoking in smokers include a slight increase in blood pressure due to vasoconstriction. The performance of white blood cells in the smoking process (that is, the concentration of white blood cells and adherence to blood vessel walls) is a normal response of the endogenous defense system. The endogenous defense system perceives cigarette smoke as an interference factor. This immune response protects the organism against the effects of the external environment. Acute changes in white blood cells observed during smoking can be tolerated by the normal immune system. However, when assessing the possible consequences of smoking, the extent and possible secondary reactions (inflammatory reactions) must be considered. Of course, it is better to hope that the local microcirculation and defense of cigarette damage are as low as possible. The object of the present invention is therefore to provide a smokeable product whose main smoke stream (MSS) and secondary smoke stream (SSS) damage or reduce the microcirculation of special oral mucosa significantly compared with the use of comparable nicotine and concentrate values The paper size of this paper applies the Chinese National Standard (CNS) A4 specification (210 X 297 mm) -------- ^ --------- (Please read the precautions on the back before filling in this Page) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs. 5. Description of the invention (3) 4 The mouth is significantly lower. At the same time, the acceptable taste is guaranteed, and the taste of the product has no adverse effect. This object according to the present invention can be achieved by a smokeable product, such as snoring cigarettes, pouting small snow plus or filtering, mouth Xuesu, a) a filter with a filter active in the gas phase and / or cigarette paper It has active ingredients in the gas phase and / or a variety of other components accessible to the main smoke stream, including active substances added to the gas phase, and b) where in leaves and / or other smokeable materials and / or other accessible Anti-oxidant substances are added to the twist of the main smoke stream. In the current month, the components of the main smoke stream can be accessed "means that smokeable products such as cigarettes, Xiaoxuesu or Xuewen will form these ingredients that can fully or partially enter the main smoke stream when smoked, or other components in the smoking process The components that can be dissolved into the main smoke stream. It was unexpectedly discovered that the present invention can achieve quite a lot of positive effects through the basic idea of the present invention. The combination of the two with opposite mechanisms will not interfere with each other, that is, they will not interfere with each other. The smoke-related part, that is, the gas phase with significant airspace and undesired substances, and the other part of the smoke, that is, the particle-phase-concentrated substance, can be combined and obtained. -Reduction of cytotoxicity by activated carbon filter (basic and applied toxicology% 1 ^ 17 (1997))-Reduction of mutagenicity (DE-PS 4 16 101 C2)-Reduction of microcirculation acceptor smoke flow and secondary smoke In addition to flow damage_Improve the taste of the main smoke flow V. Description of the invention (4)-Improve the smell of the secondary smoke flow to an unexpectedly high level. Based on the basic idea of the present invention, the air phase and the particle phase are concentrated at the same time. In principle, all experts know or are familiar with the parameters (that is, using different types of filters, using multiple tobacco leaves or tobacco leaf mixtures, using different tobacco leaf twist wraps, and selecting The ingredients that are fed with anti-oxidant substances, etc.) can be used to design cigarettes and cigars that are modified according to the machine of the invention, such as for full-flavor, medium-flavor, light smoke and ultra-light smoke. The invention thus relates to a smokeable product comprising a pout that is active in the gas phase and / or cigarette paper that is active in the gas phase and its tobacco twist and / or other smokeable materials and / or other accessible masters Smoke components are added with anti-oxidant substances. The product is wrapped in leaf paper twisted with cigarette paper or wrapped in leaf paper with non-woven paper and cigarette paper. The permeability of cigarette paper to air is 10 to 单位 Coresta units (CU), preferably Running cu, the permeability of non-woven paper to the air is 4, _ to 60, _ cu. In addition, the product contains the end leaf trap line to natural and / or reconstitute the leaf wrapper. At least: layers of reconstituted ingredients "packaging, each layer of permeability magic ㈣" air-impermeable ") or 5 yuan 〇cu (" Breathable; preferably 40 to 80 CU. In this description, 'it is necessary to understand that "a filter active in the gas phase" means a type which contains 5 to 65% by weight, preferably 2 () to 5 () weight % And especially good 30% by weight porous material with large (internal) surface area is active in the gas phase. It is preferred that the mouthpiece has a filter and a mouth ventilation section at its periphery and the mouth side bucket δυο / Α7 Intellectual property of the Ministry of Economic Affairs Printed by the Consumer Cooperatives of the Bureau of the People's Republic of China. 5. Description of Invention (Mouth ventilation is 5 to 95%, and preferably 25 to 75%. _ Mouth also contains puppets that experts know can introduce ventilated air to another point or any point needed. For example The mouthpiece wrapper and the filter can be partially or completely perforated or self-iron porous.… According to specific examples, a filter that is active in the gas phase is a double nozzle, but it can also be a single filter or a nozzle, for example. Or multiple filters, nozzles, multiple filters can be selected from the group consisting of chamber filters, nozzles, dispersers Any one of the desired combination of a single filter and / or a towel filter. Taking a dual filter as an example, the side of the trap line, such as a single filter, for example, is preferably composed of fiber paper as a whole. It contains 5 to 65% by weight, preferably 20 to 50% by weight, and particularly preferably 30% by weight. Such a material has a large surface area and is active in the gas phase. According to specific examples, a smokeable product is a filter cigarette. Tobacco twist, this is surrounded by cigarette paper, or filter, mouthpiece cigar (excluding cigarette paper) or filter cigar, the leaf twist line is surrounded by natural or reconstituted tobacco leaves or covers or envelopes. 较佳 Better The filter and more preferably the dual filter has a filter ventilation section surrounding the peripheral direction of the oral cavity, and the fiber paper on the twist side of the filter is a great valley paper. According to this specific example, the cigarette paper on the air Permeability is between 10 and 100 Curistar units (CU), preferably between 20 and 60 CU, and filter ventilation is between 5 and 95% and preferably between 25 and 75%. (In the case of a dual filter, the fiber paper on the filter side of the pick-up side) contains 30% by weight of a large area of material The filter part on the twisting side is especially the center filter, which has a material jacket that is approximately impermeable to the main smoke stream around the center of the fiber paper. Standard (CNS) A4 size ⑽ x 297 public love) (Please read first Note on the back, please fill out this page again)-Install ---- nn Order ------! Line I — I --- Α7 Β7 V. Invention Description According to the present invention, the material contained in the mouthpiece that is active in the gas phase has a large surface area and is active in the gas phase. It has a large (internal) surface area and a porous material. It is selected from the group consisting of activated carbon, oxides, hydroxides, and clays. Cellulose, celestial earth, ion exchanger, light metal salt, sepiolite, molecular sieve 'stone evening gel' alumina and buddha or combination thereof; activated carbon, sepiolite and stone evening gel in gas phase A particularly good substance with activity. Commercially available chamber pouts (3-chamber taps) in which the central chamber is filled with the aforementioned large-area material, which is active in the gas phase, and whose size can be changed with the number of gas phases to be absorbed 'can be used to form a pout. In principle, the amount of the aforementioned large-area material is 25 mg to 250 g, and the actual amount thereof varies within the aforementioned weight range depending on the particle size, the preferred ventilation density, and the degree of ventilation. The highest possible filling level of the chamber is quite critical here. It was unexpectedly found that even with relatively large amounts of substances that are active in the gas phase, such as the conventional ⑽mg live ㈣, the bad taste effects ("off-flavors", "off-smells") known to experts can be used to detect antioxidant additives such as Acetic acid vinegar of reproductive age compensates or overcompensates, and at the same time produces a particularly good odor. . The filter is made of a material known to be active in a disordered phase, such that the filter and the nozzle are dispersed (for example, a double nozzle is used as an example, and the reduced nozzle section at the inspection line side is preferably provided with embedded person # for example in the gas phase) Active granular material contains 10 to 150 mg), single-stage pouting (preferably carbon with active material in the gas phase is used for positioning such as a polyene cylindrical cylinder), multiple ^ contains at least two and is selective Different forms of the gas phase have active materials (which can also be different from each other) and pouting sections that hold a particle phase; the central sleeve or the center sleeve is made of the active material due to the gas phase, and I. ------- It · —-------. (Please read the precautions on the back before filling out this page) The paper size i§ at the time of this article (CNS) A4 size (210x297 7 9 A7 B7 Five Λ invention description

In I, the nozzle and the center are made of active materials but different from each other because of the gas phase; and other filter structures known in the industry. In this regard, the ten'pout can be ventilated by the channel, and / or the pout section can be accessed near the mouth side, or the mouth can be tapped at the center of the mouth side. All of the palatable structures are contained in the gas phase with active materials, which themselves are contained in the gas phase with active materials and phase-retaining materials. 'Substances with antioxidant properties according to the present invention, in addition to other approved additives such as Fragrances, fragrances, conventional hardeners and other additives approved for cigarettes and Xiaoxueyou. Needless to say, the filter structure included in the gas-phase active material can also provide conventional filter material with particle phase or additional filter segment with particle phase, especially using cellulose 'cellulose acetate and can retain Particle phase filter material, described in DE-PS 197 53 193 ^ DE-PS 197 53 195 ^ DE-〇S 42 05 658 It is proved in the present invention that a large area material is preferably used, and its particle size is 2 mm or less 'Preferably 15 micrometers to 2 millimeters, or less than 15 micrometers according to a specific embodiment' has an internal specific surface area in the range of 50 m 2 / g to 2 m 2 / g. This also applies to filter cigarettes and / or filter cigars or filter cigars according to the invention. In the present invention, "cigarette paper active in the gas phase" means a cigarette paper containing at least one of the aforementioned large-area pupae active in the gas phase. Thus, for example, cigarette paper can be provided with extremely fine-grained silica gel, zeolite, alumina, and the like. In addition, cigarette paper that is active in the gas phase is, for example, a double-layer leaf-leaf line wrapping paper, which is provided in a known manner with extremely fine-grained activated carbon (carbon-filled paper lining for cigarettes and cigars, · Ecusta Paper Branch 0LIN; Research Development department report = The paper size of the edition is applicable to the Chinese National Standard (CNS) A4 specification (210 X 297) 1 Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 480157 Α7 -_ Β7 V. Description of the invention (8); August 1973 27). Therefore, a preferred embodiment of the present invention is a filter cigarette, which is wrapped with two layers of cigarette paper in a leaf twist, and the inner layer contains a low-permeability cigarette paper which can reduce secondary smoke flow, and the outer layer contains The aromatized cigarette paper has a breathability of 20 to 100 CU, and preferably 40 to 80 CU. Addition to tobacco leaves and / or other smokeable materials and having an antioxidant effect, Chevrolet is selected from the group including ascorbic acid, β_carotene , Vitamin A acid, tocopherol (especially α-tocopherol), its derivatives (especially tocopherol acetate) and hydrazone, eugenol, jasmin, cinnamon, cinnamon extract, (crude) force non ( Coarse Extracts, methyl caffeic acid vinegar, ethyl caffeic acid vinegar, methyl ferulic acid, ethyl ferulic acid, umbelliferin and curcumin, which can be added to tobacco leaves individually or in combination with each other. A particularly preferred embodiment is to add α-tocopherol, tocopherol acetate (ToAc) and / or tocopheryl succinate. According to the present invention, tobacco leaf twist is added in an amount of more than 0.1% to 5% by weight (based on Tobacco leaf content), preferably 0.5 to 4% by weight, and particularly preferably 1 to 25% by weight i / 0 has an antioxidant effect. If more than one substance with an antioxidant effect is added, according to the specificity of the present invention In specific examples, the addition amount is at least 0.25% to 25% by weight / 0. According to the basic idea of the present invention, the gas phase is evacuated while the particles are concentrated, and not only a substance having a few #oxidation, but also added to The gas phase has a large spoon of large surface area, which is added to the main smoke muscle of a smokeable product. The substance added to the gas phase can be selectively combined with a gas phase active filter and / or gas. Active cigarette paper This paper scale or alternative standard applicable in ^ (CNS) A4 ^ ^ public grid ⑵g χ 297 ------ (Please read the Notes on the back to fill out this page)

| Install -------- Order --------- Line I Description of the invention (9) Filters that are active in the gas phase and / or cigarette papers that are active in the gas phase. The nature of the product is determined. The filter cigarette of the present invention has a tobacco leaf twist line surrounded by cigarette paper. Instead of leaf ', other smokeable materials, including other material mixtures containing tobacco leaves, can be used in the product according to the invention. For example, Kretek cigarettes can add up to 50% by weight of smokeable species, or pure plant tobacco without tobacco leaves also falls within the scope of the present invention. In the following, only "tobacco leaf" is described exclusively, but this term is intended to cover the other smokeable materials often. The tobacco leaves or tobacco mixtures used consist entirely or mainly of swelled or unexpanded layered tobacco leaves, but also so-called industrial tobacco leaves such as ribbed tobacco leaves or tobacco leaves (FT). In a preferred embodiment, the anti-oxidant vegetate according to the present invention is directly blended with tobacco leaf foil in a manner known in the art.于 mixed with tobacco leaf = 0.1% to 10% by weight, preferably 1% to 7%, and particularly preferably 20/4 to 4% by weight, depending on the physical properties of the substance f having an antioxidant effect according to the present invention As well as the nature of the technology and the intended use. Yu Ye is particularly suitable for small cigars and cigars, for example as covering leaves and / or enveloping leaves, but is also used directly (smokeable) on leaves or added to cigars, cigars or cigarettes in rough or fine cut form Use tobacco leaf mixture. Preferred tobacco leaf mixtures for cigarettes are ...-Pure Virginia Blend ("ash")-Ash Blend Containing Oriental Species-So-called American Blend (AB) Blend-Dark Blend (Air-Matured), etc. The mixture also contains industry leaf (rib to leaf, ft), with A7

Printed on a specific fully or partially inflated layered (# 叶) content by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs. In all cases, the mixture according to the invention and the smoking product to be produced contain substances with antioxidant properties as claimed in the present case. The ffiAB mixture is often made, for example, the car master of the present invention is based on the following mixture formulation range: a) 20 to 40% air-cured tobacco b) 20 to 70% Virginia tobacco c) 5 to 20 /. Oriental tobacco d) 0 to 25% tobacco leaf e) 5 to 15% ribbed f) 0.1 to 50%. Natural antioxidants, and other conventional additives such as "flavoring agents" and "flavoring agents". Although American admixtures (AB) mixtures are preferred, in special cases, in terms of the taste of the product, deviations from "gray" or "dark" or other tobacco leaf mixtures can be used. It is used for small cigars and cigars. It is a “dark” tobacco leaf mixture based on air-cured tobacco leaves, which naturally has antioxidant properties, and other tobacco leaves and conventional additives well known in the industry. In particular, Xiaoxuejia, a cigarette-shaped filter, is used as an example. Some and all of the natural antioxidants are better added to the leaf of tobacco leaf foil. In principle, 'antioxidant substances are not only added to the tobacco leaf, but are also blended or used in a known manner to process tobacco leaf products that are accessible to the main smoke stream', such as filters, wrapping paper, wrapped tobacco leaves, carrier substances, Sew glue and so on. If anti-oxidant substances are mixed in cigarette paper or cigarette seam glue, the preferred amount is more than 0.1% by weight to 20% by weight / 0, and the amount by weight is 1 to 7.5% by weight.

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480157 A7 5. The invention description (11) is particularly good. In addition to the aforementioned substances with anti-oxidant effects, tobacco leaves can be added with other auxiliary agents, fillers and aromatic substances (additives) in a known manner. To add a relatively large amount of anti-oxidant substances to the tobacco mixture, especially for fertility. Phenolic acetate has proven to provide cigarette twists with a double-layer cigarette twist wrap (non-woven paper), the inner layer containing a highly porous wrapping paper with breathability of 4,000 to 60,000 CU, and the outer layer containing conventional cigarette paper. Any migration of liquid additives from the tobacco leaf mixture to external cigarette paper, such as the formation of undesired spots, is preferably avoided or at least minimized. In addition, according to the present invention, a small amount of anti-oxidant substance can be added to the inner highly porous wrapping paper in the form of encapsulation, according to DE_PS 42 44 467. It is also possible to use the multi-layered wrap on the leaf to wrap the composition. For example, the most versatile special-purpose cigarette papers known to those in the industry can be combined or used with highly porous wrapping paper inside, such as aromatized paper (e.g., according to EP 0294 972), reducing secondary smoke flow paper (e.g., according to ep 0). 251 254 or EP 033 8 156) or self-extinguishing cigarette paper (for example according to ep 0375 844). These cigarette papers can of course also be used alone, for example in a single layer, especially if a relatively small amount of an antioxidant is used in a smoking product according to the invention. This probability also exists in tobacco leaf wrapping, especially for small cigars. A better tobacco leaf twist wrap combination according to the present invention is shown in Table 1. This paper size is in accordance with Chinese National Standard (CNS) A4 (210 X 297 public love) 480157 A7 B7 V. Description of the invention (12) Multi-layer tobacco leaf twist wrap composition Inner and outer tobacco leaf foil (encapsulation) FT " "Airtight" (covered leaf) Conventional cigarette paper (sheath) Highly porous paper-natural (tobacco leaf) cover leaf south degree porous to leaf fl-natural (tobacco leaf) cover leaf synthetic envelope leaf (paper) tobacco leaf foil (covered leaf ) Known cigarette paper (sheath) Highly porous paper — Known cigarette paper SSS- Reduced cigarette paper — Aromatic cigarette paper Highly porous paper — Aromatic cigarette paper Highly porous paper — — Automatic annihilation of cigarette paper porous tobacco foil — Any Required Cigarette Paper Highly Perforated Paper SSS- Reduced Cigarette Paper Aromatic Cigarette Paper Any Required Paper Highly Porous Paper Any Required Cigarette Paper Contains Activated Carbon Paper — Any Cigarette Paper Required (Please read the notes on the back before filling out this page) The first (top) box in Table 1 relates to a filter cigar and cigar according to the present invention, and the second (bottom) box relates to a filter cigarette according to the present invention. The parcels listed in principle can be exchanged or combined by themselves (in the same column) and each other (in different columns) in an appropriate manner. Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs. In addition, according to the present invention, a filter cigar, such as a cigarette-shaped filter cigar, is also provided with a tobacco leaf foil encapsulating leaf, and the encapsulating leaf is breathable or impermeable, A natural tobacco leaf covers the leaf and has a cavity filter. The center cavity of the filter is filled with activated carbon. According to a particularly preferred embodiment of the present invention, the filter used is a filter according to PCT / EP97 / 06390, which is active in the gas phase and contains activated carbon. The filter cigarette produced using this filter is 15 papers Standards apply to China National Standard (CNS) A4 specifications (210 X 297 mm) 480157 Printed by the Consumers ’Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs A7 B7 V. Description of the invention (l3) a) Contains tobacco leaf twists with air permeability of 20 to 1 〇〇CU is surrounded by cigarette paper, or tobacco twist is made of cigarette paper with air permeability of 20 to 100 CU, non-woven, wrapped, and b) contains dual filters, filter ventilation is 5 to 95%, the filter is The side of the thread line contains a large volume of fiber paper and contains 5 to 65% by weight, preferably 20 to 50% by weight of finely milled activated carbon; a filter ventilation section is provided at the mouth side portion and travels in the peripheral direction. Preferably, the shellfish is added to the grass line individually or in combination according to the present invention. However, these substances can also be added to other leaf product components according to the present invention, which are close to the main smoke stream and are preferably part of the filter side of the mouth. According to a specific example, the fiber paper used in the twist side filter element has a weight per unit area of about 40 to 60 g / m 2, an activated carbon content of 5 to 65%, and a thickness of 150 to 200 μm. A preferred variation has a weight per unit area of g / m 2 and an activated carbon content of 30% by weight at a thickness of 180 microns. In a specific specific example, the filter portion of the H-concerned mouth on the side of the mind line is a center filter and nozzle according to DE 42 05 658 C2, where the center is made of activated carbon fiber paper, as in the first specific example, The center is surrounded by a flame sleeve that is substantially impervious to the main smoke stream. This material is generally impermeable to smoke and contains highly dense cellulose acetate fibers. The filter-tipped cigarettes with comparable strength are relatively well-known. The advantage of the filter-tipped cigarettes according to the present invention is that the microcirculation, particularly the oral microcirculation, is significantly less damaged, so as to prevent the insufficient supply of tissue blood flow, as long as it is used in the gas phase. Active filter and additional anti-oxidant substance to tobacco twist (please read the precautions on the back before filling this page)

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480157 A7 B7 5. The invention description (14) is enough. Especially if α-tocopherol or tocopherol acetate is added, the positive effect can be significantly enhanced. The present invention was unexpectedly found that if a filter is used which contains, for example, activated carbon in the gas phase and has a particulate phase, at the same time, a significant amount of a substance having an antioxidant effect is added into the particulate phase, and the amount will not be affected. The gas phase and particle phase active filters are reduced or only insignificantly reduced, then the filters or filter pores that are active in the gas phase will not be "clogged" by tobacco leaf additives and will not be blocked. Unexpectedly, the filter according to the present invention has a combination of active substances in the gas phase and feeding of anti-oxidant substances can obtain the additive effect of the individual effect combination or exceed the additive effect, that is, at least additionally reduce the microcirculation. s damage. It is also found in the case of the present invention that the active substance in the gas phase can be used to reduce the content of harmful substances in the gas phase without impairing the taste, that is, to adversely affect the taste of the main smoke stream. The second smoke stream also showed no adverse changes in odor, that is, unpleasant odor. Surprisingly, it was further discovered that the feeding of conventional tobacco leaf mixtures with the aforementioned substances having antioxidant effects, even at relatively high levels, can contribute to the sensory improvement of the specific mixtures and smokeable products according to the present invention. According to a specific example of the present invention, the smokeable product is a filter cigarette. The filter is printed by the consumer cooperative of employees of the Ministry of Intellectual Property Bureau of Jibei. It is included in the leaf inspection line and is made of non-woven cigarette paper with a permeability of 40 to 60. Wrapped, non-woven paper is highly porous non-woven paper with breathable CU. Its filter is a double filter. The filter contains a large volume of fiber paper on the twisting side. It contains 30% by weight of finely milled activated carbon. The ventilating section of the mouth is in its peripheral direction. The filter contains acetic acid on the mouth side, and about 2% biophenol acetate is added to the leaf twist. Double mouthpiece has this paper standard applicable to Chinese National Standard (CNS) A4 specification (21〇X 297 public love) 480157 A7 _____B7 _ V. Description of the invention (15) Filter ventilation is about 20 to about 25%, about 50% Or about 60 to 75%, depending on whether it is full-flavor, light or ultra-light. The properties of preferred cigarette products are shown in Table 2 below. Plate 2

AB (including expanded tobacco leaves) 2 layers of twisted wire filter: approximately 12 mg inside: non-woven paper approximately 20-25% mixed with 32,000 CU air concentrate outside: conventional cigarette approximately 6 mg paper with 40-60 CU (About 50% mixed air is applicable to all three types of gas concentrate products) about 2 mg about 60% mixed air concentrate about 1 亳 g about 70-75% mixed ----air concentrate filter double filtration

Ultra-light AB (Cotton * bulging tobacco) fiber paper contains activated carbon containing about 20-30 mg of finely ground activated carbon (equivalent to 30% carbon), and cellulose acetate (CA) filters on the mouth side (suitable for the three types of products) ) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economics for the industry, it is indisputable that according to the principles of the present invention, that is, the exhaust air phase, such as filters used in the gas phase and / or used in the gas phase Cigarette paper and at the same time concentrate the particle phase by feeding anti-oxidant substances, which can also be achieved through the use of tobacco leaf cartridges (so-called push-in cigarettes). In other words, non-woven wrap is provided on the leaf picking line and the sheath is attached With active filters in the gas phase, consumers only need to push in the finished product (such as a cigarette). Such anti-oxidant substances can be added to the tobacco leaf itself and / or to cigarette paper, for example. The present invention also relates to non-woven wrapping pick-up threads and filter sheaths using tobacco leaves and / or other smokeable materials, which contain active filters in the gas phase to produce smokeable products, tobacco leaves and / or Twist of other smokeable materials and / or other paper sizes that can be connected to this paper Gu Gu Mu Jia Xian (CNS) ^ # (210 X 297 mm) 18 480157 A7 ______B7 V. Description of the invention (16) (Please read the first (Note? Please fill in this page again.) Substances near the main smoke stream are added with anti-oxidant substances. By the same token, the present invention is also similar to the use of a so-called (pull-in) r push-in cigar "combination filter sheath, and a filter active in the gas phase to produce a smokeable product according to the present invention . Therefore, the present invention also relates to the use of tobacco leaves and / or other smokeable materials twisted with natural and / or reconstituted tobacco leaves, and filters and scabbards which are contained in the gas phase and have active filters and mouths to make smokeable cigarettes. Products, tobacco leaves or other smokeable material twists and / or tobacco leaves and other packages close to the main smoke components are added with anti-oxidant substances. According to this specific example, the twist of tobacco leaves and / or other smokeable materials may wrap at least two layers of reconditioned tobacco leaves or tobacco foil. In these cases, the package can be air tight (Si CU) and air permeable (breathability is 5 to 100 CU and preferably 40 to 80 CU), or a combination of air tight wrapped tobacco leaves and air permeable wrapped tobacco leaves . The invention will be illustrated in further detail by means of the following examples. Example 1 Production of Test Cigarettes For the studies of Examples 2 and 3 below, a machine for producing whole mouth based on a desired cigarette format was used to make test cigarettes. A total of four different cigarettes were produced (Table 3). The feed of tocopherol acetate (ToAc) printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs is fed to cut tobacco in the form of a 20% ethanol solution. The procedure followed here is that each 10 kg tobacco leaf is sprayed with TOAc solution in a rotary processing drum in a manner known to those skilled in the art. The target is to obtain a tocopherol acetate content of 15% TOAc. Subsequently, the solvent was removed by evaporation at 22 C and 63% relative humidity, while conditioning cigarettes (cigarette versions 1C and 1D). An untreated tobacco leaf mixture (cigarette version 1A & 1B) was used as a comparison of the examples. 19 This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) A7

5. Description of the invention (Π) Two different nozzles are attached to cigarettes. The ferrule that is active in the gas phase is a double filter, which contains activated carbon-containing fiber paper (containing 30% by weight of finely milled activated carbon) on the twist side and cellulose acetate fibers on the mouth side. These filters are referred to as activated carbon filters (AF) in the description and cigarette versions (and). A conventional cigarette filter (cigarette versions 1A and 1D) made of cellulose acetate fiber (CA) was used for comparison. Table 3 Abbreviations used in the test product overview ToAc content (% in tobacco leaf) Category used; Total filter length (mm) Description of nozzle length Carbon paper (mm) Ventilation (%) 1A — CA 21 20 1B-— AF 21 13 17 1C 1.6 AF 21 13 17 1D 1.6 Γ CA — Round 21 — 20 (Please read the note on the back? Matters before filling out this page)-Install the printed example of the employee consumer cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs 2 During the smoking period Tocopherol Acetate Regulation Study Test The performance of tocopheryl acetate (TOAc) in smoking cigarettes with full-flavor cigarettes with activated carbon filters and activated carbon filters. The cigarette smoking method is to obtain the main smoke stream (MSS) concentrate electrostatically according to DIN 10240. The so-called secondary smoke particle phase (sss) is also separated. A total of 10 test cigarettes were smoked in an 18 cubic meter chamber lined with V2A steel, and only SSS could be dispersed in the chamber. Subsequently, 180 liters were separated into particles by flowing through a Teflon filter membrane at a flow rate of 3 liters / minute. Cigarette ends (residues of non-smoked tobacco leaves) and smoked cigarette filters are also smoked. The paper size applies to China National Standard (CNS) A4 (210 X 297 mm).

—Order -------- line I 20 480157 A7 B7 Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs. 5. Description of the invention (18) Separate after smoking and collect them individually. The MSS, SSS, cigarette butts, and smoking filters were used to prepare ethanol solutions or extracts for analysis of ToAc. ToAc was quantified using HPLC with DAD (High Performance Liquid Chromatography with Diode Array Detector). A Purospher RP 1 8 column, 5 microns, model 548163 was used. Methanol was used as the mobile phase at a flow rate of 1.0 ml / min and a temperature of 35 ° C. Detection was performed at 285 nm. Table 4 Tocopherol acetate (ToAc) enters main smoke stream (MSS) Cigarette category MSS concentrate (mg / cigarette) MSS concentrate ToAc (mg / cigarette) MSS concentrate To Ac content (%) 1C 11.3 1.42 12.6 1D 13.3 1.47 11.1 The amount of MSS concentrate (mg / cigarette) and the detected ToAc (mg / cigarette) are listed in Table 4 for various ToAc-containing cigarettes. The relative content (%) of ToAc in MSS is also shown in Table 4. The results show that the content (%) of ToAc in the MSS concentrate is comparable to that of cigarettes and cellulose acetate filters and carbon filters, with an average of about 12%. Table 5 Recovery rate of tocopherol acetate after the test smoke is shortened Cigarette category Tocopherol acetate (mg / cigarette) After being shortened by a short shovel, it is recovered from the MSS SSS filter butt Σ% Recovered 1C 11.15 1.42 3.83 0.66 2.04 7.95 71.3 1D 11.58 1.47 3.54 0.84 2.11 7.96 68.7 This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) 21 (Please read the precautions on the back before filling this page) 480157 A7 B7 Intellectual Property of the Ministry of Economic Affairs Printed by the Bureau ’s Consumer Cooperatives 5. Description of the invention (19 Table 5 shows the distribution of tAc in smoking and the difference after smoking. The second column of Table 5 shows the amount of TOAc at the beginning of smoking (mg / cigarette) In each case, the amount of tobacco leaf relative to the leaf and the ToAc amount added to the leaf leaf were calculated mathematically. Table 5 also shows the ToAc recovery amount in MSS, SSS, filter and cigarette butt (Pick / Cigarettes), and the total amount obtained, and the recovery amount (%) in each case based on the amount before the pumping. Example 3 Validation of the shadow twin material for aeration rings ^ ΐ · Test subjects: The following four test subjects were studied .All try Individuals use the form of blind test reduction, that is, neither the experimenter nor the research instructor can determine which cigarette to smoke. According to the example, the full-flavor cigarettes are marked as follows: iA, IB, 1C, and 1D 2. Individuals: Uniform random samples Eight individuals (N = 8): Caucasian male, moderate addict, no dental and other medical conditions (except mild chronic bronchitis), famous teeth, and dagger 3 "The criteria for quasi and exclusion are based on good clinical practice ( Gcp) standard (Guidelines for appropriate clinical trials of drugs) Age: 38 to 43 years (mean 40.5 years) Weight: 73 to 78 kg (mean 75.3 kg) Height · 172 to 176 cm (mean Π 4 "cm) 3 · Suitable as The definition of the standard of the study individual: (Please read the precautions on the back before filling this page) Packing ------- l · Order L ------- line

480157

The Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs printed a male Caucasian male, 38 to 43 years old, able to act; no medication; balanced social status; harmonious marriage; no clinical illness was found; no influenza infection for 4 weeks; no physical or Mental disability with at least 10th grade education (ending with vocational training). Reliable and self-disciplined (strict adherence to investigation and research instructions). Personality balance (no paranoid or biased personality structure). Moderate addicts (smoke 10 to 15 cigarettes per cigarette; each cigarette contains about 0.99 grams of nicotine and about milligrams of concentrate); no alcohol or drug abuse. 4. Definition of exclusion criteria (not applicable as a study individual): Does not meet the aforementioned inclusion criteria, see above. 5 ·-General exclusion criteria: Participation in research in the last 90 days (regardless of type); participation in other research at the same time. Alcohol, medicine or drug dependent, neurosis. Mentally ill. epilepsy. People at risk of suicide. The blood loss of the donor or the last six months is greater than 500 liters. Weight is not within the range of + / _ 10% of its relative figure, gender, and height, such as the table or Broca Index published by the MetLife Insurance Company in 1983 is greater than 150% or overweight (higher than normal) 20% of body weight). Those who believe that the consumption of coffee, leaves, or leaves is abnormal; those who think that their diet or nutrition is not balanced; those who live irregularly (non-social); may be inconsistent with Jirui's research (from a medical point of view). Volunteers who have not stated their participation in the research. 6. Exclusion criteria for medical history: allergic constitution; inherently intolerance or high sensitivity; diabetes; homouricemia; hyperthyroidism or other endocrine diseases ·, chronic or intermediate disease (cancer, tuberculosis); hypertension; Cardiac insufficiency, Coronal paper size suitable for national standard (CNS) A4 specification (210 X 297 public love) ---------— r ^ .-- 1 --- (Please read t # 'Zhuyin on the back? Please fill out this page for more details) 23 A7

V. Description of the invention (21) Printed arterial insufficiency by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs; coronary heart disease; heart valve defects; myocardial infarction; cerebral infarction; cerebral circulation disorder τΙΑ (temporary ischemic attack, cerebral circulation disorder na 4), COLD-resistant lung disease COLD; bowel surgery; any other chronic disease, f-fluid dialysis; only one fully functional kidney; prostate hypertrophy; coagulopathy. Make it clear that you want to quit smoking. 7. Exclusion criteria for detection of inclusion: Chronic liver complaints (transaminases increased to twice the normal value); kidney disease or renal dysfunction [serum creatine is greater than ^ 亳 g ^^^ mg is called or inosine Acid clearance rate is 50-80 liters / minute (less than 50 liters / minute)]; the number of white blood cells is less than 3,500 / microliter; the number of platelets is less than 100,000 / microliter. Suspected dysfunction, suspected lung or bronchial disease (except mild chronic bronchitis). Oral hygiene is required; more than 2 missing teeth; periodontal disease, gingivitis. 8. Unacceptable combined treatment: taking drugs and other substances within 90 days before the start of the study; non-drug treatment; psychosis treatment. 9. Secondary Exclusion Criteria Failure criteria included after initial inspection; exclusion criteria detected only after inclusion in the study (excluded from this study). 10. Framework requirements for the study: a) Individual: No alcohol, no coffee, tea or Coca-Cola 12 hours before the study. Sleep at least 6 hours a day; have fully adapted and rested before measurement. Blood pressure RR (measured with Riva-R0cc) is normal, heart rate is normal, and breathing rate is normal. b) Measurements: · Room temperature is about 22 ° C and relative air humidity is about 75%. The sitting paper size is in accordance with Chinese National Standard (CNS) A4 (210 X 297 mm) • -IIIIII l · ^-f--III (Please read _ read the precautions on the back before filling this page) Line_ 24 480157 A7 V. Description of the invention (22) Amount (the head is placed on the rack during the study, which is expressed according to the wishes of the test subject). The time is the same daily (hours); the weather conditions are the same. Research characteristics Binocular research nine (the progress of the study is determined by the random generator). During the observation period, the measured starting value was measured, and the exposure started at 0 minutes; during and after the exposure 2 minutes to 4 minutes 6 minutes 8 minutes 10 minutes; 12 minutes. Research 9 ¥ number (Temperature adjustment, macro-view cycle, adaptation time of about 2 hours. Exposure conditions. The Intellectual Property Bureau of the Ministry of Economic Affairs, the employee consumer cooperative prints the orientation framework conditions of breathing rate and breathing volume; individuals keep their Normal smoking habits. Individuals are exposed to various trials in the research series (the interval between exposures is greater than 24 hours). The results of individual studies and the results of each test object's exposure to individuals are determined by random producers. (Method description, Features, A continuous and complete microvascular network recorded in a 1-mm-mm volume target tissue, with a total of 60 Kirchhoff nodes (branch of microvessels, paper ruler & Zhongguan specifications (210 X 297) Centimeters) 25 480157

Description of the invention (point (23)) and the average blood vessel diameter is less than 40 microns. Before recording microbiological measurements of each in vivo test, obtain a complete network orientation overview of the target volume of the tissue, including its further inflow and outflow, branch geometry, and branch hierarchy. If necessary, vascular function identification for this study. In order to show a complete microvascular network of the target area, an in vivo biopsy examination using a combination of incident light and transmitted light using a selected light emitter and a selected filter is performed. The processing and processing of the obtained preliminary images are computer-assisted (using the CONTRON computer system for secondary image processing and processing). ○ Microscopic findings in vivo are recorded under predetermined lighting and filtering conditions. Related: incident Spectral distribution of light and transmitted light components, beam characteristics, angle of incidence of incident light components, specific filtering of reflected light components penetrating the tissue, and emission and absorption spectra of various structures of the target tissue. The instant photomicrograph of the second shadow silly swallowing is taken as a small image, film roll or flat plate (NIKON 'LINHOF with ARRI adapter; to ι / 8, 000 seconds); the bottom material conforms to ISO 3200 / 36 degrees. Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs (please read the precautions on the back before filling in this page) ), Agvat negatives; automatic Agva negatives imaging system. Video recording (U-matic, Super-VHS; JVC, International, BLAUPUNKT, Siemens). The various geometric and dynamic characteristics of the microcirculation are measured using computer-assisted image-by-image analysis; in some cases, false color transitions and computer-identified photocopy paper sizes are applicable to the Chinese National Takaoka Standard (CNS) A4 specification (21 × 297 mm) -—6-~ --- 480157 Printed A7 by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs V. Invention Description (24) Image (as seen by computer-assisted histology). ) For in vivo microscopy measurements, the macroscopic circulation architecture conditions must be strictly maintained but determined and monitored simultaneously. Figure 1 shows the structure of an in-vivo microscopy unit by a block circuit diagram. The fiber optic cable is placed on the far end of a sterilized OP cotton swab, and the optical device is fixed on a commercially available sterile cotton swab. Frequency side, while the individual is pressurized in a receptive manner. This procedural simulation mimics the situation of the individual prior to commencing the study and is acceptable to all subjects. Figure 2 shows the distal optics placed in the mouth of an individual. During the exposure period of the test subject, it was placed on the eye frame (mandibular bracket, anterior jaw bracket) according to the requirements of the individual, and matched with the individual's sitting position. Subjects did not specify exposure conditions when they were tested; they can be performed in their customary manner (aspiration, aspiration frequency, number of aspirations per test object, time). Micro Cycle £ b: In the special network unit, the number of nodes of blood cell perfusion nNp (expressed in absolute value or as a percentage change from the starting value). This feature describes the state of perfusion as "perfusion with blood cells" or "not perfusion with blood cells" according to the following criteria: time is greater than 20 seconds; restricted examples are evaluated with +0.5 or -0.5; red blood cells limit the flow rate to about 80 microns /second. Number of white blood cells adhering to the inner wall of a specific small vein nWBC / Α (stated as an absolute value or expressed as a percentage change from the comparison start value). This paper size applies to China National Standard (CNS) A4 specification (21 × 297 mm) --------- ------- line (please read and read the notes on the back before filling in this (Page) 27 480157

V. Description of Invention (25) Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs This feature describes the number of white blood cells n that adhere to the surface of a specific small vein for a period of time longer than 5 seconds. The reference area is the area of the inner wall of small blood vessels ㈣, _ square microns; the average diameter of small veins is ㈣ microns, and the length of the small vein axis is ι = ι 40 microns. * Arterial and venous blood flow Qart and Qven (expressed as absolute value or percentage change from the initial value). This feature explains the flow of red blood cells (flow intensity), that is, particle flow. Recording of measured values is computer-aided secondary image processing (Kang Chong system). The geometric dimensions of the microvessels (diameter d, radius r) are measured from the inner surface of the endothelium 1 to the inner surface of the endothelium (tangent line) perpendicular to the longitudinal axis of the blood vessel. It is shown graphically in Figure 3. Statistical information on measured values It is clear that a test method without parameters is readily apparent. Willocoxon ranks and tests on small samples but biometrically large random samples under the prerequisites of constant variables. Since the efficiency is about 95/0, it is the most accurate parameterless method. one. The test was performed at a significance level of a = 5%. The T critical value of the Wilcoson test is taken from: G.A. FergUSon, statistical analysis of spirituality and teaching month. McRosier Books New York 19 $ 9 years 3 18 pages. For each test, the measured value was compared with the starting value at the measurement time of 2 minutes to 12 minutes. Further tests are performed to see if there are significant changes in characteristics after exposure to various test articles (comparison of measured values after exposure to various test articles during measurement). D · Research j. Before the study begins, the individual first adapts and makes his blood circulation in a sitting position. The paper size applies the Chinese National Standard (CNS) A4 specification (210 X 297 mm). 28 ------- pack- ------- ^ Order L ------- line βΓ (Please read and read the notes on the back before filling in this page) Paste 157

Description of the Invention (26) Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs (monitoring body temperature with thermal measurement, measuring the systolic blood pressure and diastolic blood pressure of the system, preliminary general physical examination); and then make preliminary details of the current situation of the individual. About 20 minutes). The preliminary medical discussion is about whether to extend the adaptation period, whether to further calm the individual, and to accumulate specific doctor-individual trust relationships (following the architectural conditions and instructions to the individual before the study begins). Exposure to a particular test article was then performed in a sitting position in a laboratory in a double-blind study and recording of what was seen. Individuals were invited to follow up the medical discussion after recording the observations. Follow-up discussions are used to further strengthen the relationship of mutual trust and prepare individuals for the next study. During follow-up discussions, individuals were also asked about the test items they were exposed to, for example, to determine whether the individual was averse to that particular test item. There are quite a number of psychological or nutritional / physical factors that can produce erroneous measurements. No errors were shown in this study. E. Results The measurement devices of 8 individuals are shown graphically in Figures 4 and 5. Figure 4 shows the number of blood cell perfusion nodes (nNP) of a cigarette version, eight to 1D, as a function of time according to Example i. Figure 5 shows the number of white blood cell adherent cells nWBC / A from eight to 1D according to the cigarette version of Example i as a function of time. It can be seen from Fig. 4 that the microperfusion (significant circulation) measured by the number of blood cell perfusion nodes is damaged to a great extent by the conventional filter-tipped cigarette (18) compared with the gas-phase active pout (1B). As further shown in Figure 4, feeding conventional fermented acetate (1D) compared to conventional filter cigarettes can also reduce damage to the microcirculation to the extent of corsage dryness. The use of the filter cigarette according to the present invention is applicable to the Chinese National Standard (CNS) A4 specification (210 X 297 mm) because the gas phase has the paper size. — — — — — — — — — — — — — 111 111 l · ^ — — — — — — — _ (Please read the precautions on the back before filling out this page) 29 480157 A7 ___ B7__ V. Description of the invention (27) Active filter, nozzle and anti-oxidant feed on leaf twist The combination (here: Shengyuepan acetate 1C) showed that the effect of microcirculation was further reduced during smoking. A few minutes after the end of the exposure, the number of blood cell perfusion nodes again increased to the starting value before exposure. Figure 5 shows that the number of adhered white blood cells (nWBC / A) is used as the measurement of the immune response. When the conventional filter cigarette (1A) is drawn, the conventional filter cigarette is smoked but the tocopherol acetate is fed (1D). ) Increased significantly. In the case of a filter cigarette according to the present invention, which contains an active filter in the gas phase and the addition of an anti-oxidant substance (here, tocopherol, lc), the immune response is observed to be the lowest, expressed as the number of adhered white blood cells. This series of tests showed that the damage to the microcirculation of filter cigarettes according to the present invention is significantly reduced compared to conventional filter cigarettes, and thus represents a major improvement in the acute impact on microcirculation from a biomedical point of view. Example 4: Curcumin or ethyl ferulate was used. Example 1 A full-flavored cigarette called version 1A was used for comparison. As described in Example $, the active substances curcumin and ethyl ferulate were evaluated. Effects of entry into Mss and physiological effects. Printed by the Consumer Affairs Cooperative of the Intellectual Property Office of the Ministry of Economic Affairs. The procedure followed here is that in each case, one hundred grams of cut tobacco, such as that contained in cigarette A, is fed with a curcumin or ethyl ferulate solution. After the alcohol was removed by evaporation, it was a comparative example in terms of the tobacco leaf production format. A used handmade cigarettes. For example, there are three versions of cigarettes smoked by two households. Curcumin or ethyl ferulate analysis was performed on treated tobacco leaves and MSS concentrates. The analysis was performed as described in Example 2 using 1_11 > 1 ^ (:. However, 30 480157 was printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs to print A7 B7. 5. Description of the invention (28) The mixture of water, tetrahydrofuran, acetonitrile and acetic acid was used as the motive. Phase, especially for curcumin ratio of 55/25/20/1 and for ferulic acid ethyl ester of 77/13/9/1. Using Bluff C18 column, the detector is set to turmeric The element is 420 nanometers and the ethyl ferulate is 325 nanometers. The following Table 6 shows the active compound concentration (%) and the% recovery of the MSS concentrate in the treated tobacco leaves. Table 6 Test No. Test No. of Example 5 Active compounds in leaves (% dry matter) Enter (%) B 142 Ethyl ferulate 0.44 ------ / 34.81 B 143 Curcumin 0.87 0.63 1A — -a ------- _ Example 5 In a double-blind test, the effect of a filter cigarette manufactured according to Example 4 on the microcirculation of the oral mucosa of 8 individuals was described in detail in Example 3 (Sections A2 to D [Methods]). Test items: IA, B 142 and B 143 Results: Figure 6 shows an example of a full flavor cigarette ( According to Example 4) the number of white blood cell adhesion nWBC / A with and without curcumin and ethyl ferulate (versions IA, B 143 and B 142) is a function of time. As can be seen from Figure 6, the number of white blood cells adhered (nWBC / A) Measured immune response to exposure to conventional filter cigarettes (1A) Comparative feed has anti-oxidant effect This paper size applies Chinese National Standard (CNS) A4 (210 X 297 mm) 31 I in amamm I n 1_ · i_i .1 ϋ 1 n 1 —Hi ϋ 1_1 ϋ ·-ϋ · ϋ aaMB · Please ¾ .. Read the notes on the back before filling out this page) 480157 A7 _____ BT ^ ________ 5. Description of the invention (29) Conventional filter cigarettes with curcumin (B 143) or ethyl ferulate (B 142) have significantly increased immune responses. Example 6 American compound mixture was fed with 2% by weight of tocopheryl acetate (based on the amount of tobacco leaves) and similar examples. 丨 Production of corresponding test cigarettes and comparison cigarettes. The sensory test results of the special group showed that it contained 2% by weight. To Ac's test cigarettes compared the so-called interference factors of cigarettes such as reactivity, thickness, and spiciness. Other mixture systems were also studied (i.e., 2% by weight ToAc was fed using other tobacco leaf mixtures). In the straight Virginia mixture (cigarette), the spiciness was also significantly reduced, and the coarseness and reactivity of the mixture (cured cigar) using pure air were also significantly reduced. The typical "cigar" smell of a single smoke stream is less noticeable and less pleasant than the SSR smell of a small cigar. Brief description of the drawing Figure 1. Block diagram of the in-vivo microscopy examination unit; printed by the Consumer Affairs Agency of the Intellectual Property Bureau of the Ministry of Economic Affairs. Figure 2, a diagram of the placement of an optical device at the distal end of an individual oral cavity. The glass fiber cable is embedded in a sterile OP cotton swab and it is acceptable to ensure that it is fixed between the right mandibular tooth layer and the inside of the buccal cavity. Figure 3, the inside view of the microvessel illustrates the measurement of geometric dimensions;

Kapillare mit Erythrozyt = Microvessels with red blood cells. Figure 4, exposed to conventional filter cigarettes and tear-tipped cigarettes according to the present invention. The number of knots measured as a function of time after initiation of blood cell perfusion. Explanation (30) FIG. 5 is a graph showing the measurement of the number of white blood cells adhered after the start of exposure to a conventional filter cigarette and a filter cigarette according to the present invention as a function of time. In Figure 6, the measurement of the number of adherent white blood cells after exposure to full-flavor cigarettes with or without additives is a function of time. (Please read the precautions on the back before filling out this page) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 33 This paper size applies to China National Standard (CNS) A4 (210 X 297 mm)

Claims (1)

Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs A8 B8 -_ g8S Application for special-L A smokeable product, characterized by its ^ ^ package $ 1 filter which is active in the gas phase and / or cigarette paper which is active in the phase and / or-or a variety of other Components accessible to the main smoke stream include active substances added to the gas phase, and b) twists in leaves and / or other smokeable materials and / or other components accessible to the main smoke machine are provided to add antioxidant properties Of matter. For example, the smokeable product of claim 1 is characterized in that it is a filter cigarette, a filter cigar or a filter cigar. 3. The smokeable product according to item 1 or 2 of the patent application scope, characterized in that the filter and the nozzle contain 5 to 65% by weight of a large surface area material. 4. The smokeable product according to item 3 of the patent application, characterized in that the filter contains 20 to 50% by weight of a large surface area material. 5. The smokeable product according to item 4 of the patent application, characterized in that the filter comprises 30% by weight of a large surface area material. 6. The smoking product according to item 1 or 2 of the scope of patent application, characterized in that the filter comprises a device for introducing ventilation air. 7. The smokeable product according to item 1 or 2 of the patent application scope, characterized in that the filter has at least one filter ventilation section running along the peripheral direction of the mouth side portion. 8. The smoking product according to item 1 or 2 of the patent application scope, characterized in that the filter has a ventilation of 5 to 95%. 9. The smokeable product according to item 8 of the scope of patent application, characterized in that the filter and mouth ventilation are 25 to 75%. 10 · If the smokeable products in the scope of patent application No. 1 or 2, it is characterized in that the paper size applies to China National Standard (CNS) A4 specification (210X297 ^ FI (Please read the precautions on the back before filling out this page), · •------min — -8--1 US III ft -pack · 34 Printed by the Intellectual Property Bureau Employee Consumer Cooperative of the Ministry of Economic Affairs 480157 A8 B8 C8 _ D8 6. Scope of patent application This product includes a tobacco leaf twist, a cigarette paper wrap or a tobacco leaf twist wrapped with non-woven paper and cigarette paper reed, among which the permeability of the cigarette paper is 10 to 100 CU and its Central African fabric The air permeability of paper is from 4,000 to 60,000CU. 11 · The smokeable product according to the scope of patent application No. 10, characterized in that the cigarette paper has an air permeability of 20 to 60 CU. 12. The smokeable product according to item 1 or 2 of the scope of patent application, characterized in that the filter is a chamber filter, a gap filter, a single filter, a double-tipped nozzle, a center filter or a multiple filter, and multiple The filter is a combination of any filter selected from a chamber filter, a gap filter, a monoblock filter and / or a center filter. The filter is ventilated with a channel and / or has a recessed filter segment on the mouth side and / or a central filter on the mouth side. 14. The smokeable product according to item 2 of the scope of patent application, characterized in that it is a filter cigarette with tobacco leaves twisted and wrapped by cigarette paper, wherein the mouthpiece is a double filter or a multiple filter, which is on the twist side Part contains fibrous paper containing 5 to 65 significant surface area materials. 15 · The smokeable product according to item 2 of the scope of patent application, characterized in that it is a mouthpiece cigarette attached to a leaf picking line and surrounded by cigarette paper, wherein the thickener is a single filter containing fiber paper containing 5 to 65 Weight% large surface area material. 16. The smokeable product according to item 13 of the patent application, characterized in that the fiber paper contains 20 to 50% by weight of a large surface area material. ----— (Please read the notes on the back before filling this page) 35 480157 A8 B8 C8 D8 Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs. Patent Application Scope 17. The smokeable product under the patent application No. 16 is characterized in that the fiber paper contains 30% by weight of a large surface area material. 18. Please refer to the professional cigarette product in Item 13. The filter is characterized in that the filter has a filter ventilation section running in the peripheral direction on the mouth side, and the fiber paper on the twist side of the filter is For paper with very large volume, the permeability of cigarette paper is 10 to 100CU and the ventilation of the filter is 5 to 95%. 19. The smoking product according to item 18 of the scope of patent application, characterized in that the cigarette paper has an air permeability of 20 to 60 CU. 20. The smokeable product according to item 18 of the scope of patent application, characterized in that the filter has a ventilation of 20 to 75%. 21_ If the smokeable product of item 13 of the patent application scope is characterized in that the filter is a center filter on the side of the twisting line, and has a fiber paper center as in item 14 of the patent application scope and surrounds a substantially impermeable main Smoke flow material is lost. 22. If a smokeable product according to item 丨 or 2 of the scope of patent application, it is characterized in that the filter active in the gas phase and / or cigarette paper active in the gas phase and / or the components accessible to the main smoke stream are Each case is composed of a large surface material, selected from the group consisting of activated carbon, alumina, aluminum hydroxide, soil, cellulose, diatomaceous earth, ion exchangers, light metal salts, sepiolite, molecular sieves, silicones, Bauxite, zeolite and combinations thereof. 23. The smokeable product according to item 22 of the application, characterized in that the material with a large surface area is activated carbon, sepiolite or silicone. 24. If the smokeable product under the scope of application for patent No. 22 is characterized in that the surface area material has a particle size of 2 mm or less and an internal soap-prone surface larger than the table surface (please read the precautions on the back before filling in this Page), the paper size used Chinese National Standards (CNS) A4 specifications (2 × 297 mm) 36 Α8 Β8 C8 __________________ D8 VI. Scope of patent application ^^ One-the volume is from 50 square meters / gram to 2,000 square meters Range of meters / gram. 25. The smokeable product according to item 24 of the patent application No. 4, characterized in that the particle size is 15 micrometers to 2 millimeters or less. 26. The smokeable product according to claim 1 or claim 2, which is characterized in that it is a filter cigarette with a hook and a hook, each of which is surrounded by a cigarette paper with air permeability of 20 to 100 (υ). , Or tobacco leaf twisted by non-woven cigarette paper with breathability of 20 to 100cu, and b) contains dual filters with filter ventilation of 5 to 95%, and contains volume on the side of the inspection line The extremely large fiber paper contains 5 to 65% by weight of finely ground activated carbon, and a filter ventilation section is arranged on the mouth side to travel in the peripheral direction. 27. The smoking product according to item 26 of the patent application, characterized in that the fiber paper contains 20 to 50% by weight of a large surface area material. 28. The smokeable product according to item 1 or 2 of the scope of patent application, characterized in that the tobacco leaf line is added with more than 0.1% by weight of a substance having an antioxidant effect. 29. The smokeable product according to item 28 of the scope of patent application, characterized in that the tobacco leaf twist is added with a substance having an antioxidant effect of greater than 0.1% to 5% by weight. 30. The smokeable product according to item 29 of the scope of patent application, characterized in that a substance having an antioxidative effect is added to the leaf trap line in an amount of greater than 0.5% to 4% by weight. 31. The smokeable product according to item 30 of the scope of patent application, characterized in that the tobacco leaf twist is added with an antioxidant effect of 1% to 2.5% by weight. This paper applies the National Standard (CNS) A4 specification (21GX297). (Mm) (Please read the notes on the back before filling out this page) Order-Printed by the Consumers 'Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs 37 1 Printed by the Consumers' Cooperative of the Intellectual Property Bureau of the Ministry of Economics C8 —., Patent Application Scope ^ ~- --- The substance. 32. The smokeable products according to the scope of patent application No. 1 ~ ^ 2 are characterized by a wide range: substances with anti-oxidant properties are selected from the group consisting of ascorbic acid, carotene, vitamin A acid, fertility, derivatives and Precursor, Dingzi's 'Mo_Cinnamon' cinnamon extract, (crude) coffee, (crude) coffee extract, methyl caffeate, ethyl caffeate, methyl ferulate, ethyl ferulate, Umbelliferin and curcumin, these materials λ can be added in combination with each other in products such as the application for special and enclosing items = products, which are characterized by anti-oxidant substances as fertility hope and fertility Acetate and / or tocopheryl succinate. 34. For example, please refer to the smokeable product in the scope of the patent, which is characterized in that the tobacco leaf twist is additionally added with auxiliary agents, fillers and aromatic substances. 35. If the smokeable product in the scope of the patent application is No. 丨 or 2, It is characterized in that it is a filter cigarette containing tobacco twists made of non-woven paper wrapped with cigarette paper having a permeability of 40 to 60 cu. The non-woven paper is a highly porous non-woven paper with a permeability of 32,000 CU, and its filter is The dual filter has a filter ventilation of about 20 to about 25%, a fiber paper containing Guzhengda at the side of the twisting line, and 30% by weight of finely ground activated carbon, which is provided with a filter ventilation section in the peripheral direction. Traveling and containing cellulose acetate on the mouth side, tobacco leaf twists are added with about 2% tocopheryl acetate. 36. Smoking products such as those in the scope of patent application No. 丨 or] are characterized in that this paper scale applies to China National Standard (CNS) Α4 specifications (210x297 ^ 51 ~ one by one--38-(Please read the precautions on the back before filling out this page) | equipment., Language, ί g---τιι — # -—ί 1— ji ϋβ gi— -Ministry of Economy and Trade Printed by the Consumer Affairs Cooperative of the Property Bureau, A8, B8, C8, D8. The scope of the patent application is that the filter cigarette is contained in the pen private. # I θ ^ & leaf twist line is wrapped by a cigarette paper with air permeability of 40 to 60 CU. The paper is a two-degree porous non-woven paper with air permeability of 32, _⑶, and the money mouth is a dual filter with a mouthpiece ventilation of about 50%, and a fiber paper with a large volume at the inspection line side contains 30% by weight Finely milled activated carbon is set up with a ventilator ventilation section running in the peripheral direction and contains cellulose acetate on the mouth side, and about 2% tocopheryl acetate is added to the leaf twist line. 37. As for the scope of patent application_ The smokeable product of the item is characterized in that it is a dub cigarette contained in the leaf line and is wrapped with a non-woven cigarette paper having a breathability of 40 to 60 cu, and the non-woven paper is a breathable 32,000,000. Highly porous non-woven paper, and its dual nozzle is a dual filter with a filter ventilation of about 6G to about 75%, a fiber paper containing a large volume on the twist side side, and 30% by weight of finely ground activated carbon. Sighed The wind section travels in the peripheral direction and contains cellulose acetate on the mouth side. Tobacco twist is added with about 2% tocopheryl acetate. 8. As a smokeable product in the scope of patent application No. 1 or 2, it is characterized by its For filter cigarettes, the tobacco leaf twist is wrapped in two layers of cigarette paper, the inner layer contains low permeability cigarette paper which can reduce secondary smoke flow, and the outer layer contains aromatized cigarette paper with a permeability of 20 to 100 CU. 39 · 如The smokeable product under the scope of patent application No. 38 is characterized in that the aromatized cigarette paper has a breathability of 40 to 80 CU. 40. The smokeable product under the scope of patent applications No. 1 or 2 is characterized in that it is The filter cigar has a tobacco leaf foil encapsulation leaf, which is breathable or non W-scale. Applicable medium ~~-~-(Please read the precautions on the back before filling this page) 39 480157 6. Scope of patent application Ventilation and a natural tobacco leaf covering the cavity and the filter of the chamber, the central chamber of the filter is filled with activated carbon. 41 · The use of a non-woven wrapping twist of tobacco leaves and / or smokeable materials and a filter sheath, the sheath contains a filter which is active in the gas phase and can be used for production, such as the scope of patent application No. 丨 or 2 The smokeable product is characterized in that the tobacco leaf and / or other smokeable materials and / or other twists that are close to the main smoke component are added to have an antioxidant effect. 42. The use of tobacco leaves and / or other smokeable materials twisted to natural and / or reconstitute tobacco leaf wraps and filter sheaths. The filter sheaths include a filter that is active in the gas phase and can be used for production. The smokeable products of the scope of patent No. ι or 2 are characterized in that the tobacco leaf and / or other smokeable material twists and / or tobacco wraps and / or other components close to the main smoke stream are added with anti-oxidant substances . Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs 43_ —The use of tobacco leaves and / or other smokeable materials twisted with at least two layers of re-dried tobacco leaves or tobacco leaf foil and a filter sheath, the filter sheath contains A filter that is active in the gas phase and can be used to produce smokeable products such as those in the scope of claims 1 or 2 of the patent application, characterized in that the tobacco leaf and / or other smokeable material twists and / or at least one tobacco leaf wrap and / Or other substances close to the main smoke stream are added to have an antioxidant effect. 44. The application according to item 42 of the scope of patent application, characterized in that the wrapper is air-tight or air-permeable or contains a combination of air-tight tobacco leaves and air-pervious leaves. 210X297 mm) 40