TW476640B - Disposable article, article for detecting the presence of vaginal infections, and absorbent interlabial device - Google Patents

Abstract

A disposable article to be fitted to a wearer and other types of articles having a detection device, such as a diagnostic panel that may, in one set of embodiments, include at least one biosensor, each including at least one bio-recognition element. The biosensor is adapted to detect a target biological analyte in body substances, and on/or through the wearer's skin. The diagnostic panel may be adapted to determine the physical condition or state of well being of a mammal, or the cause of a particular disease state, such as diarrhea, vaginal infections, sexually transmitted diseases (STD's), and other diseases, and to signal the caretaker, the wearer, or an actuator of the occurrence. Examples of physical conditions of the state of well being include, but are not limited to, ovulation and the onset of menstruation.

Description

476640 A7 -_______ B7 V. Description of the Invention (1) Field of the Invention The present invention relates to disposable objects and other types of objects having a detection device. For example, a diagnostic panel in a set of embodiments includes a biosensor 'This biosensor has a biometric element to detect micro-organisms and / or other biomolecules present in the mammal's body, and in particular has a means for detecting micro-organisms that can be present in body substances and / or through the skin and / Or other biological molecules, the present invention also relates to other types of detection devices and methods of using the same. BACKGROUND OF THE INVENTION Nowadays, disposable items such as diapers, adult incontinence pants, tampons and tampons are widely used in daily use and the care of infants and young children, and are used to care for incontinence or menstrual adults as a kind of containment, Device for isolating and disposing of body waste. These items all have replaceable, reusable, washable fabrics, which make them a better device for these applications due to their convenience and reliability. Disposable objects are those that absorb or contain body waste deposited on the object in response to a defecation, urination or discharge event. Some disposable objects also send signal notifications after defecation, urination, or discharge events (such as humidity indicators, temperature change detection). Other disposable absorbent objects known in the art include a method for detecting wearer excreta. Chemically reactive device for various substances. However, it does not specifically detect microbial targets that may cause disease, such as bacteria, viruses, tadpoles and parasites (such as protozoa) and / or related micromolecules, which require a high degree of selectivity compared to pure chemicals ( (Ie specificity) and sensitivity. In addition, the article does not predict when health-related events will occur and informs the wearer or caregiver of the need to take precautions before clinical observable symptoms begin or this paper size applies the Chinese National Standard (CNS) A4 specification (210 X 297 mm) (Please read the phonetic on the back? Matters before filling out this page) · IIII n IH σ], I d ϋ ιϋ n ϋ ϋ n. Printed by the Consumer Property Cooperative of Intellectual Property Bureau of the Ministry of Economic Affairs 476640 No. 89114348 Chinese Patent Application Revised page (May 90) 5. Description of invention (2) Remedial measures. SUMMARY OF THE INVENTION The present invention is directed to disposable objects and other objects including a detection device, such as a diagnostic panel that can include at least one biosensor and at least one biometric element in a set of embodiments. Biosensors are suitable for detecting a target biological analyte (including body fluids, body excretion, other body emissions) in and / or through the skin released from mammalian bodies. Disposable objects can be Includes a diagnostic panel suitable for determining the physiological or health status of a mammal, or the cause of a particular disease such as diarrhea, vaginal infections, sexually transmitted diseases (STD), and other diseases, and notifying the caregiver or wearer or the occurrence of Event actuator. Examples of health or physiological conditions include, but are not limited to: ovulation and onset of menstruation. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a plan view of an embodiment of a diaper of the present invention, in an unfolded state and part of a structure is cut out to more clearly show the structure of the diaper; 1 C is a cross-sectional view of the diagnostic panel shown in Figure 1 B taken along line 1 c -1 c in Figure 丨 b; printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs ----------- (Please Read the precautions on the back before filling this page) Figure 1D is a plan view of an example of a diagnostic panel similar to Figures 1b and 1C, but with a wiping mechanism; Figure 1E is along the line 1D of Figure 1D A cross-sectional view of the diagnostic panel shown in FIG. 1D taken by E; FIG. 2 shows a perspective view of a body excrement isolation device of the present invention in a compressed state before starting; -5-

4 / 〇b4U A7

FIG. 2 is a cross-sectional view taken along line 2a-2a of FIG. 2 in FIG. 2; FIG. JA shows that the discontinuous response system of the present invention has an ideal output function with a single low limit; FIG. 3B shows the discontinuous response system of the present invention An ideal rotation function with multiple low bounds; Figure 4A shows an exemplary output function of the discontinuous response system of the present invention and first, second and third order derivative functions of this output function; ^ 4 B shows The transfer function of a series of first-order time-lag technology systems with equal time constants; Figures 5 A and 5B show an embodiment of the response system of the present invention with an electrically sensitive colloid; Figures 6A, 6B, and 6C show a system including an electrical Another embodiment of the response system of the present invention with sensitive colloid; FIG. 7 is a perspective view of an excrement bag of the present invention; FIG. 8 is a perspective view of an absorbent article including an excrement bag; H 9 is an implementation of the pant pad of the present invention A plan view of the example; Figure 9 A is a cross-sectional view of the pants pad embodiment shown in Figure 9 A taken along line 9 A-9 A of Figure 9, showing the diagnostic panel on the pants in detail; Figure 10 shows that it can be used for detection Microorganisms, biomolecules or other phases Examples of the chromaticity indicator of the amount of substance; Figure 11 illustrates a color comparison chart that can be used to indicate the amount of substance that appears; Hui 12 is a plan view of an embodiment of a sanitary napkin of the present invention; Plan view of the invented interlabial device; Figure 1 ^ shows the interlabial device shown in Figure 13 taken along the line 1 4-1 4 of Figure 13-6-This paper size applies the Chinese national standard < CNS) A4 Specifications (210 X 297 mm) (Please read the notes on the back before filling out this page) Packing ---- Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 476640 No. 89114348 Patent Application A7 Chinese Manual Correction Page (90 May 2015) B7 V. Description of the invention (4) Sectional view; Figure 15 is a side view of the interlabial device shown in Figure 13; Figure 16 is a side view of the interlabial device shown in Figure 13 showing the interlabial device How to hold and insert into the space between the labia of the wearer; FIG. 17 shows how the interlabial device is worn by the wearer's body; and FIG. 18 is a perspective view of a tampon embodiment of the present invention. Description of component symbols 10 Diagnostic panel 37 Cross-region 12 Biosensor 38 Second waist region 14 Biosensor 40 Fastening system 16 Biosensor 45 Absorbent core 28 facing to the clothing surface 17 Mask 50 Diameter of diaper 20 18 Base material 52 End edge of diaper 20 19 Wiping mechanism 60 Biosensor 20 Diaper 62 Absorbent core 28 Waist edge 22 Base 80 Controller 24 Liquid permeable top layer 90 Actuator 26 Liquid impermeable bottom layer 91 Pressure difference device 28 Absorptive core 92 Soluble bag 30 Side panel 94 Compressed elastic material 32 Foot flanging 96 Gap space 34 Elastic waist feature 100 Diaper 20 midline 36 First waist area 102 Diaper 20 Midline Midwest Bureau of Economics Staff Consumption Printed by the cooperative (please read the precautions on the back before filling this page) This paper size applies to the Chinese National Standard (CNS) A4 (210X297 mm) 476640 Patent Application No. 89114348 printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs Revised page of the Chinese manual (May 90) 5. Description of the invention (4a) 110 Excrement disposal device 968 Sensor element 111 Excrement 970 sensor element 112 flange 980 cover 120 diaper 982 capillary strip 121 opening 1090 comparison table 124 top layer 1220 sanitary napkin example 485 pin 1260 diagnostic panel 494 electrosensitive gel 1320 interlabial device embodiment 594 electrosensitivity Gel 1338 Bottom layer 595 Mesh grill type 1342 Top layer 920 Pant pad embodiment 1344 Absorbent core 924 Pant top layer 1352 Handle 960 Diagnostic panel 1360 Diagnostic panel 962 Sensor element 1820 Sanitary tampon 964 Sensor element 1860 Diagnostic panel 966 Detailed description of the invention of the sensor element "Absorbent article" herein refers to a device that absorbs and blocks body emissions, especially a device that is placed against or near the wearer's body to absorb and block various emissions from the body. "Disposable" in this article means an absorbent article that is generally unintentionally washed or retrieved or re-used as an absorbent article (that is, it is disposed of after a single use, preferably recycled, buried or disposed of in other environmentally friendly ways) (this article "configured ”Means that the components of the object are formed (joined and positioned) in a specific part or location-7a-(Please read the precautions on the back before filling in this page) Clothes · The size of the paper applies to the Chinese National Standard (CNS) A4 (210X297 mm) 476640 No. 89114348 Patent Application Chinese Specification Revised Page (May 90) 5. Description of Invention (4b), as a unitary structure for other elements of an object, or as another joint to an object Separate components of an element; "joining" herein includes the construction of directly fixing one element to another element by directly attaching the element to another element, and attaching the element to an intermediate element and then attaching the element A configuration in which an intermediate member is attached to another element so that the element is indirectly fixed to the other element). A "unitary" absorbent article refers to an absorbent article in which separate elements combine to form a cooperating entity without the need for separate manipulation elements such as separate holders and pads. The term "body substance" refers to substances released from the mammal's body. "Body substance" includes bodily fluids and biological fluids such as vaginal discharge, menstruation, sweat and saliva, body excretions such as urine and feces, and any other Body emissions such as tears and semen. (Please read the notes on the back before filling this page) Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs 7b This paper is sized for the Chinese National Standard (CNS) A4 (210X297 mm) 476640 A7 B7 V. Description of the invention (5 ) (Please read the precautions on the back before filling out this page) An embodiment of an absorbent article that can have a biosensor diagnostic panel according to the present invention is a unitary disposable absorbent article, such as the diaper 20 shown in Figure 丨. A diaper herein refers to an absorbent article generally worn around the lower body of infants and incontinent persons. The present invention is also applicable to other absorbent and non-absorbent articles, such as incontinence shorts, incontinence bottoms, absorbent inserts, diaper holders and pads, colostomy bags for natural or artificial anus, feminine hygiene devices (including but not Limited to panty pads, sanitary napkins, interlabial devices and tampons), wipers, disposable towels, tissue paper (including toilet paper), saliva samples, water-absorbing articles, oil-absorbing articles, vomiting bags, dehydration bags, disposable Wipes, bandages, therapeutic coverings, supports, disposable heating pads or the like. Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs. Figure 1 is a plan view of the diaper 20 in the unfolded state. Part of the structure is cut out to show the structure of the diaper 20 more clearly. The portion of the diaper 20 facing the wearer is oriented toward the viewer. As shown in FIG. 1, the diaper 20 preferably includes a liquid-permeable top layer 2 4 and a liquid-impermeable bottom layer 2 6; an absorbent core 28, preferably between at least a part of the top layer 2 4 and the bottom layer 26. Side; 30 side panels; elasticized foot cuffs 32;-an elastic waist feature 34; and a fastening system 40. The diaper 20 has a first waist region 36, a second waist region 38 opposite to the first waist region 36, and a crotch region 37 between the first and second waist regions in FIG. The periphery of the diaper 20 is defined by the outer edge of the diaper 20, wherein the longitudinal edge 50 is generally parallel to the longitudinal centerline 100 of the diaper 20, and the end edge 5 2 running between the longitudinal edges 50 is transverse to the diaper 20 The center line 1 02 is almost parallel. The base 22 of the diaper 20 includes a main body portion of the diaper 20. The base 22 includes at least a part of the absorbent core 28 and preferably an outer cover layer. In addition, the cover portion includes a top layer 24 and a bottom layer 26. If the absorbent article contains a separate holder and the paper size is in accordance with Chinese National Standard (CNS) A4 (210 X 297 mm) 476640 A7 B7 V. Description of the invention (6) A lining, the base 22 contains the holder And the pad (for example, the holder may include one or more layers of material to form the outer cover of the article, and the pad may include an absorbent assembly that includes a top layer, a bottom layer, and an absorbent core. In this case, The holder and / or the pad may include a bulky element to hold the pad in place using a private person). For unitary absorbent articles, the base 22 contains the main structure of a diaper and adds other features to form a composite diaper structure. Although the top layer 2 4, the bottom layer 26, and the absorbent core 26 can be assembled into a variety of conventional structures, the better diaper structure is generally described in the following cases: 丨 January 4, 975 issued to Kenneth B. Be U.S. Patent No. 3,860,003 entitled "Contractible Sides for Disposable Diapers"; U.S. Patent No. 5,151,092 issued to Beale on September 9, 1992; issued on June 22, 1993 U.S. Patent No. 5,221,274 to Beyer; U.S. Patent No. 5,554,145 issued to Luo et al. On September 10, 1996, entitled "Absorbent Articles with Stretchable Waist Features of a Multi-Zone Structural Elastic Film Fabric," ; On October 29, 1996, issued a certificate to U.S. Patent No. 5,569,234 entitled "Disposable Pull-On Pants" issued by Beale et al .; U.S. Patent No. 5,580,411 for a method of manufacturing a zero waste material for side panels for absorbent articles "; U.S. Patent Application No. 08 / 915,471 entitled" Absorbent articles with multidirectionally stretchable side panels ", said by Robert et al. Each case is incorporated herein by reference. The bottom layer 26 is generally the adjacent absorbent core 2 in the diaper 20 The portion of the garment facing surface 45 that is 'used to prevent absorbed and enclosed excrement from arguing objects that may come in contact with the diaper 20', such as sheets and panties. The bottom layer 26 may be joined to the top layer by any attachment means known in the art. 2 4. Absorbent core 2 8 or any other element of diaper 2 0. Appropriate backing film system including Teraherd, Indiana. The actual paper size is applicable to China National Standard (CNS) A4 (210 X 297 mm). (Please read the precautions on the back and fill in this form «nnn ϋ. Ϋ« ϋ ·-Order -------. Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 476640 A7 B7 Employee Consumption of the Intellectual Property Bureau of the Ministry of Economy Printed by the cooperative V. Description of the invention (7 x5310, X10962 & X10964 manufactured and sold by Dig Industries. Other suitable substrate materials may include breathable materials such as wovens, nonwovens, composite materials such as film coating Non-woven fabrics and microporous membranes, such as ESPOIR NO manufactured by Mitsui Tokai Co., Ltd .; EXXAIRE of EXXON Chemical Co., Texas; or monomeric films, such as Cincinnati, Ohio HYTREL Blend P18-3097 manufactured by Crope Company. These breathable composite materials are detailed in EI DuPont's PCT Application No. W095 / 16746 published on June 22, 1995; issued on February 2, 1999 U.S. Patent No. 5,865,823 to Curo; U.S. Patent No. 5,571,096 issued to Doblin et al. On November 5, 1996, each of which is incorporated herein by reference. The bottom layer 26 or a part thereof may be elastically stretched in one or more directions. In one embodiment, the bottom layer 26 may include a structural elastic film (SELF) fabric. The structural elastic film fabric is a stretchable material that can exhibit elasticity in the elongation direction without adding an elastic material. The SELF fabrics suitable for the present invention are described in May 21, 1996, issued to Sharpel et al., Entitled "Fabric material exhibiting elasticity," US Patent No. 5,518,801, incorporated by reference In another embodiment, in another embodiment, the bottom layer 26 may include an elastomer film, foam, wire harness, or a combination thereof, or other suitable materials with a nonwoven or synthetic film. The top layer 24 is preferably compliant and tactile Soft and non-irritating to the wearer's skin.-Appropriate top layer 24 can be made from a variety of materials, such as cell-shaped foam + 帛; mesh foam; open-cell plastic film; or natural fibers (such as wood fibers or cotton fibers), synthetic fibers (Such as polyester or polypropylene fibers) woven or non-woven fabrics, or a combination of natural and synthetic fibers. If the top layer includes fibers, these fibers can be knotted: carded, wet-Uid, meltblown, Water tangles, or other places known to the art-to. (Please read the precautions on the back before filling this page)

• ϋ ϋ ϋ ϋ i I · ϋ nn an I n I— I ^ / b64〇A7 ------- B7 ----- '-----— V. Description of the invention (8) Principle . A suitable top layer 24 of a fabric containing a man-made segment of polypropylene fibers is P-8 manufactured by Ferretk Corporation, an international paper company of Wapel, Mass. A suitable top layer of the shaped film is described in US Patent No. 3,929,135 issued to Thompson on December 30, 1975, entitled "Adsorption Structure with Push-out Capillaries"; on April 13, 1982, issued to Mulan et al. "Disposable absorbent article with an antifouling top layer, US Patent No. 4,324,246; issued on August 3, 1982 to Reddall et al., Entitled" Elastic Plastic Film Showing Fibrous Properties, "the United States Patent No. 4,342,3 No. 14; U.S. Patent No. 4,463,045, issued on July 31, 1984, to Yaer et al., Entitled "Grand-view swelling three-dimensional plastic film fabric with no visual gloss surface and cloth-like touch" ; U.S. Patent No. 5,006,394 entitled "Multilayer Polymer Film" issued to BYD on April 9, 1991. Other suitable top layers 24 are manufactured in accordance with U.S. Patent Nos. 4,609,518 and 4,629,643 and U.S. Patent No. 4,695,422 and U.S. Patent No. 5,520,875 issued to Kuruo et al. On September 2, 1986 and December 16, 1986, respectively. Incorporated herein by reference. These formed films are available from "DRI-WEAVE" of Protest Corporation of Cincinnati, Ohio, and "CLIFF-D" of Trudiger, Indiana, Indiana. The top layer 24 may be made of a water-repellent material or may be Processed to be water repellent to isolate the wearer's skin from the liquid contained in the absorbent core 28. If the top layer 24 is made of a water repellent material, it is preferred to treat at least the upper surface of the top layer 24 to be hydrophilic to allow liquid to pass through the top layer faster The top layer 24 can be made hydrophilic by treating it with a surfactant or using a surfactant in the top layer. Appropriate methods of treating the top layer 24 with a surfactant include spraying with a surfactant -11-This paper size applies China National Standard (CNS) A4 (210 X 297 mm) c Please read the precautions on the back before filling in this page) ▼ 丨 Installation

tmMm team in ^ · MM · whm a ·· w ··· I Printed by the Intellectual Property Bureau of the Ministry of Economic Affairs and Consumer Cooperatives 476640 A7 B7 V. Description of the Invention (9) > Li Top 2 4 and the activity of immersing the material in the interface Agent. For a more detailed description of this treatment and hydrophilicity, please refer to: U.S. Patent No. 4,988,344 entitled "Absorbent Articles with Multilayer Absorptive Layers" issued to Ruixin et al. On January 29, 1991, and issued on January 29, 1991 US Patent No. 4,988,345 issued to Ruixin entitled "Absorbent article with fast-acquiring absorbent core". For a detailed description of some suitable methods of using a surfactant in the top layer, see Aziz et al., July 997 The United States Decree Invention Registration No. H1670 announced 1st, each reference is incorporated herein by reference. Any part of the top layer 24 or other components of the object may be coated with a liquid agent known in the art, a suitable liquid agent Examples include the following: Disposable absorbent articles coated with a topcoat coated with a liquid having a softener and a polyhydrocarbyl compound-containing fixative on March 4, 1997, U.S. Patent No. 5,607,760; U.S. Patent No. 5,609,587 entitled "A Diaper with a Liquid Top Layer Containing a Liquid Polyhydrocarbon-Based Polyester Softener and a Fixative" issued on March 11, 1997; 1997 June 3 Issued a certificate to Luo et al., "A diaper with a liquid-coated top layer containing a polysiloxane softener ,, US Patent No. 5,635,191; issued to Luo et al. On July 1, 1997, entitled" A diaper with a liquid coating top layer, US Patent No. 5,643,588. During the above-mentioned water repellent treatment, the liquid solution can work alone or in combination with another agent. The top layer can also include or be treated with an antibacterial agent. Some examples are disclosed in Teresa Johnson's PCT Publication No. W095 / 24173 titled "Absorbent Articles Containing Antibacterial Agents to Control Odor," September 14, 1995. Also, the top layer 24, the bottom layer 26, or any portion of the top layer or bottom layer may be embossed and / or matte polished to provide a more cloth-like appearance. (Please read the notes on the back before filling out this page) I --- I ---- ^ ----— II-- Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs -12

4 / 004U A7 B7 Printed clothing for employees' cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 5. Description of the invention (10 Absorbent core 28 may include general compressibility, compliance, non-irritating wear, absorption and indwelling such as urine and other specific Body excretion, etc. Any absorbent material. The absorbent core 28 can be made in a variety of sizes and shapes (such as long, hourglass, τ, asymmetric, etc.) and can include disposable diapers and, etc. Various liquid-absorptive wood pulps (abbreviated as air fleece) for absorbent articles. Examples of other suitable absorbent materials include: grooved continuous fibrous fillers; meltblown polymers including coforms; chemically hardened, modified, or crosslinked fibers Plain fiber; paper, including tissue wrapping materials and tissue stacks; absorbent foam; absorbent sea ladder; superabsorbent polymer; absorbent glue material; or any other conventional absorbent material or combination of materials. Type of absorbent core 28 And structure can also be changed (for example, the absorbent core or other absorbent structures can have varying card diameter regions, hydrophilic gradients, superabsorbent gradients, or lower average density and lower average basis weight acquisition (Or may include one or more layers). ° An exemplary absorbent structure described as an absorber assembly was issued to Weissman et al. On September 9, 1986, entitled "High Density Absorbent Structure," US Patent 4,610,678. No .; US Patent No. 4,673,402 issued to Weismen et al. On June 16, 1987, entitled "Absorbent Article with Double Core"; issued to Alor Manny, et al. On May 30, 1989, named US Patent No. 4,834,735, "High-Density Absorptive Member with Lower Density and Lower Basis Weight Acquisition Area"; issued on December 19, 1989 to Angustel, "Absorbing core with a wiping layer, U.S. Patent No. 4,888,231; issued to Harlan et al. On August 11, 1992 entitled "Absorbing Structure Containing Individualized Polycarboxylic Acid Crosslinked Wood Pulp Cellulose Fibers," U.S. Patent No. 5,137,537; 1992 September 15 issued a certificate to Yang Ge and others named `` -13- $ paper size timely _ home standard (CNS) A4 size (210 X 297 mm) ·-installed ------ 丨 order- ------- (Please read the notes on the back before filling out this page) Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs 47 6640 -------- 1 --------- B7__ V. Description of the invention (11) Loss of efficiency for absorbing objects with sufficient plantar, US Patent No. 5,147,345; August 1994 On the 30th, the company issued a certificate entitled "U.S. Patent No. 5,342,338 for disposable absorbent articles for low-viscosity excretory substances; on January 9, 1993, it issued a certificate to Dimari et al. For" absorbent bubbles for aqueous body fluids " U.S. Patent No. 5,26,345, cotton material and absorbent articles containing the material; issued to Dell et al. On February 7, 1995, entitled "Absorbent Foam Material Maintaining a Thin Type Before Wetting for Aqueous Body Fluids and Its Manufacturing method, U.S. Patent No. 5,387,207; July 22, 1997 issued a certificate to Dimarry et al. Entitled "Absorption for aqueous fluids made with high internal phase emulsions with extremely high water-oil ratios" Foam material, US Patent No. 5,625,222; each case is incorporated herein by reference. The diaper 20 may also include at least one elastic waist feature 34, which helps provide improved fit and containment. The elastic waist feature 34 preferably extends at least longitudinally outwardly from at least one waist edge 62 of the absorbent core 28 and generally forms at least a portion of the diaper 2 0 sleeve 5 2. Disposable diapers are often constructed with two elastic waist features. One is located in the first waist region 36 and the other is located in the second waist region 38. Also, the elastic waist feature 34 or any of its constituent elements may contain one or more separate elements attached to the diaper 20, and the elastic waist feature 34 may constitute other elements of the diaper 20 (such as the bottom layer 26, the top layer 24, or An extension of the bottom layer 26 and the bottom layer 24). The elastic waist feature 34 can be composed of several different structures including: US Patent No. 4,515,595 issued to Kiewit et al. On May 7, 1985; US Patent No. VII issued to Laxi on December 1, 1985? ... "; U.S. Patent No. 5,151,092 issued to Beale on September 9, 1992; U.S. Patent No. 5,221,274 issued to Beale on June 22, 1993. Other suitable waist structures may include the Chinese standard (CNS) A4 specifications (2_1Q χ tear public Chu>) for this paper size (please read the precautions on the back before filling this page) -install -------- order- -------- 0 476640 Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 5. Description of the invention (12) A7

Waist cover features, such as described in US Patent No. 5,026,364 issued to Robertson on June 25, 1991 and US Patent No. 4,816,025 issued to Formman on March 28, 1989; the above cases are mentioned by reference Incorporated herein. The diaper 20 may also include a fastening system 40. The fastening system 40 preferably includes a tape and / or hook and loop fastening assembly, but any other conventional fastening device is generally acceptable. The Shaofen Demonstration Fastening System was issued on January 19, 974, i.e., issued a certificate to Bel named "belt fastening system for disposable diapers," US Patent No. 3,848,594; May 5, 1987 Issued to Guangjin et al. US Patent No. 4,662,875 entitled "Absorbing Articles"; July 11, 1989 Issued to Sequip, entitled "Disposable Diapers with Improved Fastening Device," US Patent No. 4,846,815 ; Issued on January 16, 1990 to Nestegor, US Pat. No. 4,894,060, entitled "Disposable diapers with improved hook-and-loop fasteners," issued on August 7, 1990 Baltic's U.S. Patent No. 4,946,527 entitled "Pressure Sensitive Fasteners and Manufacturing Method"; and U.S. Patent No. 5,151,092 issued to Bel on September 9, 1992; and 1993 US Patent No. 5,221,274 issued to Beale on June 22. The fastening system can also provide a device for holding objects in a disposable configuration, such as US Patent No. 4,963,140 issued to Robertson et al. On October 16, 1990, each of which is incorporated herein by reference. in. In another embodiment, the opposite sides of the garment may be stitched or welded to form pants, which may allow the article to be used as a pull-on diaper, such as school pants. The diaper 20 may also include a side panel 30, and the side panel 30 may be elastic or stretchable, because the elasticized side panel 30 may expand and contract the side of the diaper 20 to fit the diaper 20 comfortably at first To the wearer and maintain this cooperation throughout the diaper 20 with laxative discharge, and to provide a more comfortable and contoured fit. -15- This paper size applies to China National Standard (CNS) A4 (210 x 297 mm) ) (Please read the note on the back? Matters before filling out this page). Equipment ^ / 6640 V. Description of the invention (13 Printed and printed by the Employees' Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs. Although diapers 20 are better equipped with second cloth 20 can be accompanied with side panels of 30 in the 38, urinary pi 』Wu Wu with and in the _ waist area 36 in the middle, the side 30 in the area 38 plus" one brother-waist area 36 and the first Two waistband I side panels 0. The side panels 30 can constitute any chemical copper Η &gt; 苽 t γ η plus &lt; Tian Gou k, a target example of a diaper with elasticized side panels I was disclosed in: 1989 What &amp; " 1Gu Yu issued a certificate to Wood et al. On the 15th to have a disposable urine with pine nuts and ears ^ · iqqq ^ ^ π &lt; Wu Guo Lee 4,857,067, issued a certificate to Sharaphat on May 3, 1983; issued on July 3, 1989, and was granted a patent of <4,381,781 indole of Gongbo Temple & U.S. Patent 4,938,753; above 1992 US patent issued to Beale on September 9 ^; US patent 5,22i issued to Beale on June 22, and issued to Lavong et al. US Patent No. 5,669,897 for "Matching Absorbent Articles"; US Patent Application No. 08 / 915,471 entitled "Absorbent Articles with Multi-Directional Extensible Side Panels" by Robo et al. August 20, 1997; Incorporated herein by reference. The diaper 20 preferably further includes a foot cuff 32 to improve containment of liquids and other body fluids. The foot cuff can also be referred to as a foot strap, side panel, barrier cuff, or Elastic Flanging. U.S. Patent No. 3,860,003 describes a disposable diaper having a retractable foot opening with a side panel and one or more elastic members to provide an elasticized foot flanging (gasket flanging) .Issued to Yaziz on February 28, 1989 and March 20, 1990 U.S. Patent Nos. 4,808,178 and 4,909,803, et al. Describe disposable diapers with "standing" elasticized wings (barrier cuffs) to improve the containment of the foot area. Issued on September 22, 1987, respectively Lawson and U.S. Patent Nos. 4,695,278 and 4,795,454 issued to J.C. on January 3, 1989, have the following descriptions: including gasket flanging and barriers. 16- This paper standard is applicable to China National Standard (CNS) A4 (210 X 297 mm) (Please read the precautions on the back before filling out this page) Τ Pack ---- 476 640 A7 B7 V. Description of the Invention (14) Disposable diapers with double flanging and other flanging. In some embodiments, all or a part of the foot flanging may be treated with one liquid as described above. The diaper 20 may also include: a pouch for receiving and enclosing excreta; a fixing member for providing a space for the excreta; an obstacle for restricting the movement of the excreta in the object; a compartment or a gap for the Receiving and containing fecal matter i, and the like deposited in the diaper; or any combination. An example of a bladder and a foot fastener used in an absorbent article is described in a U.S. Patent No. 5,514,121 entitled `` diaper with repellent fasteners, '' issued to Luo et al. On May 7, 1996, and issued in December 1992. Issued a license on 15th to U.S. Patent No. 5,171,236 entitled "Disposable Absorbent Article with Core Fixings"; issued a certificate on 14th March 1995 to "Absorbent Article with Capsule Flanging" US Patent No. 5,397,318 issued on July 30, 1996; US Patent No. 5,540,671 entitled "Absorbent article with a apex and a clamshell clamshell" issued to Juer on July 30, 1996; published on December 3, 1993 For "fixtures used in sanitary absorbent articles and disposable absorbent articles with such fixations, PCT Application No. W093 / 25172; Certificate issued to Freeland on April 26, 1994 entitled" For Disposable Flexible fixings for absorbent articles, US Patent No. 5,306,266. Examples of compartments or voids are disclosed on January 6, 1990, and are issued to the Customs with the name "disposable excrement compartment diapers," US Patent No. 4,968,312; issued to Freeland on February 5, 1991, entitled U.S. Patent No. 4,990.00,147 for an elastic lining absorbent article for excretory substance isolation; U.S. Patent No. 5,62,840 issued to Hert et al. On November 5, 1991, entitled "Disposable diapers," ; Issued on December 14, 1993 to Freeland US Patent No. 5,269,755 entitled "Three-Segment Top Layers for Disposable Absorptive Articles and Disposable Absorptive Articles With Such Three-Segment Top Layers". Appropriate Horizontal Barriers Example Description-17- This paper size applies to China National Standard (CNS) A4 (210 X 297 feet) (Please read the precautions on the back before filling this page)

I &lt; I 1 tnnn I ^ OJ · IIII 1 III Φ Printed by the Consumers' Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs 476640 A7 B7 V. Description of the invention (15 described on September 10, 1996 US Patent No. 5,554,142 of "Multiple Effective Height Horizontal Compartment Absorptive Articles"; July 7, 1994, issued a certificate to Mouri et al., Entitled "Absorbent Articles with Upright Horizontal Compartments," PCT Patent W094 No. 14395; issued on August 5, 1997 to Luo et al., Entitled "absorptive article with oblique straight three horizontal compartments," US Patent No. 5,653,703. The method is incorporated herein. The embodiment of the present invention may also include an excrement disposal device, as shown in FIG. 7 'The excrement disposal device 110 may include an excrement bag 11 () to collect feces, urine, or two The excrement bag 11 丨 may have an opening 12 丨 and a flange U2 surrounding the opening to better adhere to the area around the anus of the wearer. Also, the excrement treatment device 11 is known to be fitted with clothing or a diaper (Preferably disposable diapers) is particularly effective when used Beneficial. An example of an absorbent article (such as a diaper 12) including a fecal bag 111 is shown in Figure 8. If attached to a diaper 120 or other clothing, the fecal bag 1 can be placed on any surface of the article In one embodiment, the excrement bag u 丨 is joined to the top layer 124 of the diaper 120. The excrement bag 111 is preferably a flexible container for containing defecation or urine. Therefore, the excrement bag 1 1 1 is preferably liquid impermeable or breathable. Therefore, the excrement bag 丨 丨 丨 is designed to have sufficient strength to withstand general wear and tear conditions (such as when sitting down). The excrement bag 111 may contain one or Multi-layer, in one embodiment, the excrement bag 111 may include three layers, preferably one film and two nonwoven layers. The bag material layer may include any material, preferably making the bag liquid-impermeable. One of the invention In a preferred embodiment, a non-woven layer and a film can be used to form a stack. -18- This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) (Please read the precautions on the back first (Fill in this page again) -------- «— ^ wi. Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs

476640 V. Description of the invention (16) A suitable film material for any film layer preferably includes a thermoplastic material. The thermoplastic material may be vapor permeable or impervious, and may be selected from various types of hot-melt adhesives, polymer Hydrocarbons, especially polyethylene, polypropylene, amorphous polyolefins, and the like; materials containing fusible components, and fusible components containing fibers or polymerizable binders, including natural fibers such as cellulose Pulp, cotton, jute fiber, hemp fiber; synthetic fibers, such as glass fiber, rayon, polyester, polyalkylene, acrylic resin, polyamide, polytetrafluoroethylene, polyimide; binders such as Two-component high-melting / low-melting polymers, copolymer polyesters, polyvinyl chloride, polyacetic acid / gas ethylene copolymers, copolymers polyamines' materials containing a mixture of partially infusible constituent materials; air and Vapor permeable materials, including microporous membranes, such as the above substrates and monomeric breathable materials, such as HYTRELtm from DuPont and elf from France

Atochem's Pebax ™ fecal bag 111 can have any shape and size. Preferred shapes include flat round bags, conical bags, truncated conical bags, pyramidal or truncated pyramidal bags, and flat T-shaped bags. Also, the excrement bag lu may be made of a single piece of material or several pieces of the same or different separating material sealed at each periphery. The excrement bag 111 may also contain an absorbent material. The absorbent material may include any absorbent material capable of absorbing and retaining liquids. The absorbent material may include various liquid absorbent materials commonly used in disposable diapers and other absorbent articles. Copy example. The excrement bag 111 has an opening 121, so that excreta or urine is received from the body before being stored in the bag cavity. The opening 121 is preferably surrounded by a flange 2 and can have any shape or size, such as circular, oval, ---------- I equipment -------- order-- ------- (Please read the precautions on the back before filling out this page) Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs

Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs 4/6640 A7 ---------- B7__ χ _____________ Α, Description of the invention (17) Heart-shaped and can be symmetrical or asymmetrical, the opening is better Oval configuration in longitudinal or transverse direction. The flange may contain protrusions designed to fit the wearer's perineal, reproductive and / or coccyx regions. The flange 112 should be made of a soft, flexible and plastic material to easily place the flange 112 around the anus or urogenital area. Typical materials include non-woven materials, woven fabrics, open-cell thermoplastic foams, closed-cell thermoplastic foams, composites of open-cell foams and stretch nonwovens, and films. The fecal bag 111 preferably further includes an attachment device to secure the device = wearer. The device may include a strap, and / or a body-compatible pressure sensitive adhesive applied to the excrement pouch towards the wearer's part or flange. The device can be attached to the wearer's anus or urogenital area using any skin-friendly, water-resistant pressure-sensitive adhesive, such as hydrocolloid and hydrogel adhesives. A crosslinked polymer having a plasticizer to form a three-dimensional matrix is used to construct a particularly effective provision of the required adhesive properties to secure the flange to the wearer's skin in the sensitive anal area and can be applied and moved less painfully. In addition to the adhesive. The present invention may also be implemented in and / or on other absorbent or non-absorbent articles. Such articles are, for example, incontinence pants, incontinence underwear, absorbent inserts, diaper holders and pads, natural or artificial anal colon production Pockets, feminine hygiene devices (including but not limited to pants, sanitary napkins, interlabial devices and tampons), wipes, disposable towels, tissue (tissue and toilet paper), items that can take saliva samples such as toothbrushes, Lipstick or lipstick, absorbent article, oil absorbent article, vomit bag, dehydration bag, disposable rag, end band, therapeutic covering support #, tangible heating pad or the like. The position of the diagnosis panel can also be -20-This paper size is applicable to China National Standard (CNS) A4 specification (210

---- ^ --------- (Please read the precautions on the back before filling out this page) Installed by the Intellectual Property Bureau of the Ministry of Economic Affairs and printed by the Consumer Cooperatives 476640 A7 B7 V. Description of the invention (18) One or Multiple types of the above-mentioned objects are separated, and one or more of the above-mentioned objects can be used as a collection device for collecting related body fluids, and the body fluids collected in this way can then contact a diagnostic panel. In addition, some other embodiments may use cotton swabs, tablets, liquid containers, and the like to collect relevant body fluids. Non-limiting examples of pant pads and sanitary napkins that may have a diagnostic device include the following made by Breguet, Inc. of Cincinnati, Ohio: ALWAYS® ALLDAYS® pant with DriWeave® manufactured according to U.S. Patents 4,324,246, 4,463,045, and 6,004,893 ; ALWAYS® Ultra-Thin Slim Enlargement with Wing Type manufactured according to U.S. Patents 4,342,3 14, 4,463,045, 4,556,146, B1 4,589,876, 4,687,478, 4,950,264, 5,009,653, 5,267,992, Re. 32,649; ALWAYS® Extra Large with Wings Type; ALWAYS® — as large as possible; ALWAYS® oversized with wing type; ALWAYS® oversized with wing type; ALWAYS® oversized with wing type; ALWAYS® oversized with wing type; ALWAYS® overnight Increased with wing type. Examples of panties with a diagnostic device are shown in FIGS. 9 and 9A, and examples of sanitary napkins with a diagnostic device are shown in FIG. Non-limiting examples of interlabial devices that may have a diagnostic device are described in: U.S. Patents 5,762,644, 5,885,265, 5,891,126, 5,895,381, 5,916,205, 5,951,537, 5,964,689, 5,968,026, Des. 404,814, and 413,669, with one Examples of interlabial devices for diagnostic devices are shown in Figs. Non-limiting examples of tampons and their applicators that can have a diagnostic device are described in U.S. Patents 4,726,805, 4,846,802, 4,960,417, 5,087,239, 5,279,541, 5,346,468, 5,348,534, 5,531,674, -21-This paper is sized to Chinese national standards (CNS) A4 specification (210 X 297 mm) (Please read the precautions on the back before filling this page) Install tr --------- 476640 A7 B7 V. Description of the invention (19) 5,566,435. In addition, the diagnostic device can also be placed on a digitally inserted tampon. An example of a tampon with a diagnostic device is shown in FIG. The object 20 preferably also includes at least one indicator or detection device such as a biosensor 60. A "biosensor" includes a biosensor that contains a biosensor suitable for the detection of one or more target microorganisms or related biomolecules (such as enzyme sensors, sensors, tissue sensors, microbial sensors, immunoassays, or electrochemistry). The component of one or more components of the sensor) may or may not cause microbes. The biosensor component preferably provides the detection signal to the wearer, caregiver or actuator. Specific In an embodiment, the element may be bioreactive, chemically reactive, tethered, or may be operated by physical slander. The term "bioreactive" is defined herein as being capable of being selectively selective to the target microorganism and / or related biomolecules. Interaction and preferably restrain it. This article "bioreactivity, including but not limited to elements that detect the presence of enzymes. In general, biosensors function by providing a device that specifically binds and thus detects a target biologically active analyte. Therefore, biological Sensors are highly selective, even in the presence of a mixture of many chemical and biological entities such as feces, menses, sweat, and saliva. Chemical sensors, on the other hand, rely on chemically reactive devices and generally do not Highly selective and without the magnifying properties of biosensors, it is not suitable for detecting bioreactive analytes, especially in the presence of low concentrations and / or in a complex medium such as body fluids, body waste, and other bodies Emissions). The target biological analyte is often a secondary component of a complex mixture of multiple biological and other components. Therefore, in many biosensor applications, it is necessary to detect ten target analytes. One billionth, one trillionth, or lower 为此 For this reason, biosensors in Fu-22- This paper standard applies to China Standard (CNS) A4 Specification (21〇x297mm) (Please read the precautions on the back before filling in this page) in an i δ, (i mt I n ϋ ϋ —i I-employee of Intellectual Property Bureau, Ministry of Economic Affairs Printed by the Consumer Cooperative 476640 A7-—----—_ —__ B7__________ V. Description of the invention (20) Miscellaneous This compound may need to identify the target biological analyte to a discrimination ratio of approximately or greater. 本The biosensor preferably includes a biometric recognition element or molecular recognition element to provide a very specific binding detection selectivity for a specific analyte. The biometric recognition element or system can be a biological derivative; such as an enzyme or enzyme Sequence;-antibody; a membrane receptor protein; DNA; '·' cell organelle, a natural or synthetic cell membrane; a complete or partial viable or non-viable bacterial, plant or animal cell; or a piece of plant or mammal 'And, the age and its general function is to specifically interact with a target biological analyte. The biometric identification element is responsible for selectively identifying the analyte and the physical and chemical signal that can be used as the basis for the output signal. The detector may include a biocatalytic biosensor and a bioaffinity biosensor. In the embodiment of the biocatalytic biosensor, the biometric element is “biocatalytic, and may include an enzyme, an organelle, Plant or mammalian tissue blocks, or whole cells. Selective restraint sites are “turned around,” (also very likely to be used again during the detection process) to significantly magnify the input signal. These biocatalytic sensors are generally effective For real-time continuous sensing. Bioaffinity sensors are generally applicable to bacteria, viruses and toxins and include chemosensor-based biosensors and / or immunological sensors (ie, immunosensors). Chemical sensing A body is a complex collection of biomolecular molecules, part of which is responsible for making a viable organism capable of sensing chemicals in the environment in a highly selective manner. Chemosensor-based biosensors include one or more natural or synthetic chemosensors that are associated with a device to provide a signal of the presence of a target biological analyte or one of its concentrations (visual- 23- This paper size applies to Chinese National Standard (CNS) A4 (210 X 297 mm) (Please read the precautions on the back before filling this page)

II · n -n Ha ϋι I In —ϋ 一 0,, · n · ϋ ϋ n · ϋ it in I Printed by A7 in the Consumer Property Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs ^ --------- B7___ Five 、 Explanation of the invention (-mouth (please read the notes on the back before filling this page), bluff,% signal, etc.). In a specific embodiment, the chemoreceptor may be connected to an electrode (ie, a telecommunication transducer) to provide a detectable electrical signal to the sensory body which may include a whole or a part of a nerve bundle (such as from the antennae). Or /, other senses ", doped g) and / or whole or part of natural or synthetic cell membranes. On the other hand, the biorecognition elements of immunosensors are generally antibodies, and the antibodies are very specific and can target bacteria, Viruses, microbial fragments (such as bacterial cell walls, worms, or parts thereof), and large biomolecules. Suitable antibodies can be single gram Ik or sense clones. In any case, bioaffinity biosensors It is irreversible, because the receptor part of the biosensor will become saturated when exposed to the target biological analyte. In a special embodiment, biocatalytic and bioaffinity biosensors can be combined, such as RNA / DNA detection Pin or other high-affinity binding system, which is a biological amplification of the signal after the initial biometric event. For example, a small amount of organisms (preferably small Biosensors with genetic material (such as DNA) at or equal to about 500) and pcR (ie, polymerase chain reaction) amplification to detect a specific bacterium. Biocatalytic and bioaffinity biosensor system details Journal of Chromatographic Analysis, 510 (1990) 347-354 '&amp; Encyclopedia of Odmar Chemical Technology Encyclopedia, 4th Edition Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs (1992), John Wailey, New York Bookstore, where the disclosure is incorporated herein by reference. The biosensor of the present invention preferably detects biologically active analytes that are imminent (i.e., symptoms may occur in the future) or are related to the current state of the body's disease, including but not Limited to pathogenic bacteria, parasites (such as any stage of the life cycle, including eggs or parts of eggs, cysts, or mature organisms), viruses, tadpoles such as -24- This paper applies Chinese National Standard (CNS) A4 Specifications (21〇X 297 public love) 476640 A7 B7__ 5. Description of the invention (22) Such as Candlda alblcans, antibodies to pathogens, and / or toxins produced by microorganisms. In addition, biosensors Targets bioactive analytes related to upcoming or current local health issues, such as stress proteins (such as cytokines) and IL-1 alpha (interleukin 1-alpha) that can appear before clinical skin irritation or inflammation In a preferred embodiment, the biosensor operates in a pre-sensing mode to detect and inform the wearer or caregiver of a condition that is imminent before a clinical syndrome appears, and there is time to prevent or remediate the wearer. Preventing or significantly reducing the severity and time of the syndrome. Furthermore, the biosensor 60 can detect and biosensor by detecting the target biological analytes present in the wearer's body emissions (such as feces). Contaminants on surfaces that are in contact with the device (such as skin) and provide appropriate signals. The physicochemical signals generated by the one or more biometric elements can be visually communicated to the wearer or caregiver (ie, for example, in a chroma sensor, discoloration visible through the human eye). Other embodiments may generate optical signals, and other instruments may be required to enhance the signals, including fluorescence, bioluminescence, total internal reflection resonance, surface plasma resonance, Raman method, and other laser-based methods. Exemplary surface plasmon resonance biosensors that can contain bioconjugated surfaces as biometric identification elements are IBIS and IBIS II from the XanTec analysis system in Munster, Germany. In addition, the signal can be processed by a related signal electrical measurement converter. For example, the signal electrical measurement converter can generate an electrical signal (such as current, potential, inductance or impedance) and display it (such as can be read on an LED or LCD display). ) Or trigger an audible or tactile (such as vibration) signal or trigger an actuator, as described herein. The signal can be qualitative (such as indicating the presence of the target biological analyte) or quantitative (that is, measuring the amount or concentration of the target biological analyte). These implementations-25- (Please read the precautions on the back before filling this page) ， 装 一 -1 &gt;, · 111111. Printed by the Intellectual Property Bureau Staff Consumer Cooperatives of the Ministry of Economics This paper is printed in accordance with China National Standard (CNS) A4 (210 x 297 mm). A7 __B7____ 5. Description of the Invention (23) In the example, the signal electrical measuring converter can selectively generate an optical, thermal, or acoustic signal. In any case, the signal can also be continuous (i.e. usually stable and readable at least as long as the lifetime of the object) or transient (i.e., recording an instant measurement 値). In addition, the signal can be transmitted to a remote indicator (for example, via a wire, a transmitter such as an infrared or radio frequency transmitter), including a remote device or object or other locations on the object. Furthermore, the biosensor 600 or any component may be adapted to detect and / or notify only that the concentration of the target biological analyte exceeds a predetermined low limit (for example, when the target biological analyte normally appears in a body substance or when analyzed Concentrations lower than those known to be "dangerous". As described above, the target analyte suitable for detection by the biosensor of the present invention may be a pathogenic microorganism, such as a pathogenic microorganism related to human gastrointestinal diseases, especially those who cause diarrhea. Due to the number of children who are seriously ill or die each year due to diarrheal diseases, this type of pathogen is particularly important in monitoring. It is known that severe chronic diarrhea can cause weight loss and permanent physical and mental development disorders. The non-restricted list of pathogenic bacteria detected by Biosensor 60 includes any of the following pathogenic strains of E. coli (commonly known as E. Coli): including enteropathogenic E. coli (EPEC), enterotoxicity E. coli (ETEC), enterohemorrhagic E.coli (EHEC), enteroinvasive E.coli (EIEC), and enteroadhesive E.coli (EAEC) strains; Salmonella strains, including Salmonella typhimurium, Salmonella paratyphoid, S. enterididitis , S.typhimurium and S.heidelberg; Shigella strains such as Shigella sonnei, Shigella flexneri, Shigella boydii and Shigella dysenteriae; Vibrio cholerae; Mycobacterium tuberculosis; Yersinia enterocolitica; Aeromonas hydrophila; Plesiomonas -26- China National Standard (CNS) A4 Specification (210 x 297 Public Love) (Please read the precautions on the back before filling this page)

nnnn-OJ · nn · an nn «ϋ §§§ I 476640 A7 _____B7 ___ V. Description of the invention (24) (Please read the notes on the back before filling this page) shigelloides; Campylobacter strains, such as c.jejuni and C. coli; Bacteroides fragilis; and Clostridium strains, including C. septicum, C. perfringens, C. botulinum, and C. difficile. Non-limiting examples of commercially available biosensors suitable for the detection of coliform bacteria are Test Group # 4001 from Underkell Corporation of Dern, North Carolina and ImmunoCard from Meridian Diagnostics, Cincinnati, Ohio. ®STAT! Coliform Plus 057Plus Assay. Another non-limiting example of a commercially available biosensor suitable for detecting rotavirus is available from the ImmunoCard® S TAT! Rotavirus Assay of Meridian Diagnostics, Inc. of Cincinnati, Ohio. Another non-limiting example of commercially available biosensors suitable for detecting Cryptosporidium and Lambert's flagellates is available from the Merifluor Crypto / Giardia assay at Meridian Diagnostics, Inc. of Cincinnati, Ohio. Another non-limiting example of a commercially available biosensor suitable for detecting C. vulgaris is available from Meridian Diagnostics' Advanced C.difficile toxin A assay in Cincinnati, Ohio. ABTECH Scientific, Yardley, PA, offers "Analytical Bio-Signal Signal Transducers" with the name Au_1105.5-FD-X 'which can be co-opted by Zidflo, enzymes, antibodies or DNA fragments. The valence is fixed to the surface and is biologically specific (for the microorganism or other target biological analyte described herein). For other suitable microbiological sensors, please refer to US Patent Nos. 5,948,694, 6,0001,556; 5,106,965 (Adenoids) Virus); 5,869,272 (gram-negative organisms); 5,795,717 (Shigella); 5,830,341; 5,795,453; 5,354,661; 5,783,399; 5,840,488;; 5,723,330; 5,496,700, each of which is incorporated by reference into the biosensor of the present invention is suitable for detection The target analyte to be measured can also be a virus. -27- This paper size is applicable to the standard (CNS) A4 (end of 210 ^) 476640 A7 B7

V. The description of the invention (25) may include viruses that cause diarrhea, such as rotavirus, adenovirus (_ dsDNA virus), astrovirus (_ RNA virus), dance disease ------- ---- Equipment— (Please read the precautions on the reverse side before filling out this page) calcivirus (—an RNA virus), and Walker factor virus (Panthora vulgaris), or rhinovirus and human immunodeficiency Viruses (HIV) and other viruses. Exemplary biosensors suitable for detecting HIV are described in the aforementioned U.S. Patents 5,830,341 and 5,795,453, each of which is incorporated herein by reference. In other embodiments, the target analyte suitable for detection by the biosensor of the present invention can also detect parasites, especially at a certain point in the life cycle (such as eggs or parts of eggs, oocysts, vegetative bodies, adults) Parasites that live in the gastrointestinal tract. Such parasites can include protozoa, worms and other gastrointestinal parasites. Other examples of detectable parasites include Entamoeba histolytica (causing amoeba dysentery), Cryptosporidium, Lambert flagellates, Dientomeba fragilis, Trypana cruzi (causing Charles disease), Plasmodium falciparum 〇 In other embodiments The target analyte suitable for detection by the biosensor of the present invention may be a fungus, such as Candida albicans. In addition to pathogenic bacteria, specific colonic bacteria can be detected and / or measured as health indicators, such as Bifidobacteria and Lactobacillus strains. The consumer cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs printed the target analyte suitable for detection of the biosensor of the present invention may be a protein or antigen related to skin discomfort, preferably before clinically observable skin irritation occurs. These analytes are preferably detected on or above the skin surface and may include stress proteins such as cytokines, histamines, and other immune response factors, including interleukins (such as IL-1 from, IL-2, IL -3, IL-4 and IL-8) and interferons (including interferons a and g). Furthermore, it is better to start before clinically observable rash, irritation, or dermatitis occurs. -28- This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) 4 / 004U Α7

Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs ==. Detect. In addition, the biosensor of the present invention is suitable for detecting enzymes or other biological factors related to stress (such as diaper dermatitis), including trypsin, elk trypsin, and lipase. According to a specific preferred embodiment of the present invention, the object may include a diagnostic panel, and the "diagnostic panel" includes two or more biosensors suitable for detecting whether a group of specific substances up to two substances is present. Combination of organs, or other types of indicators ^ These substances can be the physical condition or health status of mammals, or specific causes of sadness (such as diarrhea, vaginal infections, sexually transmitted diseases (STD) and other diseases) t indicator . For example, biosensors are suitable for detecting the presence of at least two of a specific set of pathogens to determine the type of pathogen or a particular pathogen that causes a specific disease condition, and make a rough diagnosis and initiate a remedial course. For example, the object may include a diagnostic panel suitable for determining one or more causes of diarrhea or vaginal infection. The diagnostic panel is suitable for detecting physical conditions or health symptoms. Examples include, but are not limited to, ovulation and menstrual period. Examples of substances suitable for detection to determine the onset of menstruation include, but are not limited to, progesterone, peptone, and red blood cells (heme). In the embodiment of the diagnostic panel in which the object of the present invention is particularly suitable, the diagnostic panel can indicate to the user a common cause of diarrhea virus. This article provides instructions to warn users, caregivers, or medical personnel that the cause of diarrhea is viral. The diagnostic panel may include a biosensor suitable for detecting at least two of the following viruses: rotavirus, adenovirus, astrovirus, dance virus, and Walker factor virus. However, the diagnostic panel is better able to detect as many of the above causes of viral diarrhea as possible. In any case, the diagnostic panel provides a signal from the user, caregiver, or medical staff to indicate the specific viral diarrhea.-29 This paper size applies to China National Standard (CNS) A4 (210 X 297 public love) (Please read first (Notes on the back then fill out this page)

mn in n I ln Bn 11 * 1 tn I See 476640 No. 89114348 Patent Application Chinese Specification Revision Page (May 90) ^ V. Description of Invention (27) Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs, or Only the cause is indicated as viral. Alternatively, the object may include a diagnostic panel suitable for detecting any underlying bacterial cause of diarrhea or vaginal infection. In a particularly preferred embodiment, the diagnostic panel may include a biosensor adapted to detect at least two of the following: enteropathogenic coliform (EPEC), enterotoxic coliform (ETEC), intestinal bleeding E. coli (EHEC), intestinal invasive coliform (EIEC), and entero-adhesive E. coli (EAEC), Campylobacter (Campylobabacterjejuni), Vibrio cholerae and Shigella-like bacteria S. sonnei and S. flexned. However, the diagnostic panel is better able to detect as many of the above-mentioned causes of bacterial abdominal / bird or vaginal infections as possible. The diagnostic panel preferably indicates whether any of the aforementioned bacterial causes of diarrhea or vaginal infection have occurred. In any case, the signal provided by the diagnostic panel to the user, caregiver, or medical staff is preferably to indicate the specific cause of diarrhea or vaginal infection ( (I.e., bacterial pathogens), and can be used for specific early treatment of health conditions. In addition, the object may include a diagnostic panel suitable for detecting any potential viral and bacterial causes of diarrhea (or) vaginal infections. In certain preferred embodiments, the '#break panel may include one or more suitable for detecting at least A virus biosensor and one or more biosensors adapted to detect at least one bacterium. However, the diagnostic panel is better able to detect as many of the above bacterial and viral causes as possible (or vaginal infections). In any case, the signal provided by the diagnostic panel to the messenger, caregiver, or medical staff is preferably indicative of a specific cause of diarrhea (or vaginal sensation) (ie, a viral or bacterial pathogen), so special treatment for health conditions can be made early. Alternatively, the object may include a diagnostic panel that is suitable for detecting specific protozoan causes of diarrhea. In this embodiment, the diagnostic panel may include a biosensor suitable for debt measurement of one or more of the following: Crypt〇sp〇ddium organic dye test ----------- (please first Read the notes on the back and fill in this page again.) ·· 30 This paper size applies the Chinese National Standard (CNS) M specification (210X297 mm) 476640 A7 B7 V. Description of the invention (28), Lambert flagellate, Dientomeba fragilis And Entamoeba histolytica. Moreover, the diagnostic panel is preferably able to detect the occurrence of as many of the above-mentioned protozoan diarrhea causes as possible. In this case, the signal to the user, caregiver, or medical staff is better to point out the specific protozoan cause of diarrhea, and specific treatment for the health condition can be made early. Of course, the diagnostic panel may be adapted to detect any combination of the causes of diarrhea. For example, the diagnostic panel may include a biosensor suitable for detecting the toxicity, bacterial and protozoan causes of two or more of the aforementioned diarrhea. The object may include a diagnostic panel suitable for detecting and notifying specific protozoa or causative agents of a vaginal infection in a manner similar to that described in the previous two paragraphs of diarrhea. A non-limiting example of an exemplary diagnostic panel 10 for a disposable diaper is shown in Figs. 1B-1E. The diagnostic panel 10 includes two biosensors I]: a biosensor 14 is suitable for detecting E. coli H0157 and a biosensor 16 is suitable for detecting rotavirus. Available from Meridian Diagnostics

Imimmo Card® STAT! E. coli 0157P1US and ImmunoCard® ST at! Rotavirus group obtained biosensor 12 to manufacture diagnostic panel 10. The biosensors take out their respective "cards" and are attached to an exposed surface of a substrate by any attachment or bonding device (such as an adhesive) known in the art. The substrate 8 may preferably include, for example, paper , Cardboard, polyolefin film, etc., any suitable material. In one embodiment, the substrate i 8 is a relatively hard cardboard material. As shown in FIG. 1C, one having an opening corresponding to the biosensor 2 The mask 7 is applied to the surface of the substrate 18 to ensure that the excrement only contacts the biosensor 12 itself and not the rest of the surface of the substrate 18. The substrate 18 or the mask 17 can be made of, for example, plastic, hard Made of any material such as cardboard or paper, and can include labels, instructions for use, or -31-This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) (Please read the precautions on the back before filling in this Page) Outfitting ---- Order --------- Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 476640 .. A7

V. Description of the invention (29) Employees of the Intellectual Property Bureau of the Ministry of Economic Affairs print clothing and other indicators to help test or interpret the results. For example, the substrate 18 may include-discoloring "keys" to help the user interpret the results correctly. The diagnostic panel 10 is attached to the anal condyle location of the wearer via any attachment or bonding device (such as an adhesive) known in the art. Corresponding to the wearing surface of the top layer of the diaper in the diaper area. In addition, you can add the Rotavirus biosensor directly to the anus of the wearer. The diaper top surface in the diaper area corresponds to the wear-facing surface of the diaper pouch corresponding to the position to manufacture a diagnostic panel. In any of the above embodiments, the diaper top layer may include at least one opening, and the diagnostic panel 10 may be attached corresponding to the top opening The absorption core below = domain. Regardless of the chosen structure, the world object will contact the "sample," area of the two biosensors 12 when it is discharged. When the diaper is removed from the wearer or the fecal sample is applied to the biosensor, the fecal sample can be selectively diluted with a diluent such as the diluent in the ImmunoCard® STAT! Group. This is especially useful when the sample is solid. In any case, the results can be read from the biosensor 12 approximately 10 minutes after defecation, or 10 minutes after the sample is diluted with the addition of a diluent. In particular other embodiments, the biosensor 12 can be attached to any area of the diaper, such as a top layer, a bottom layer, a flange, and a fastener. In these embodiments, when the diaper is opened or removed from the wearer, the fecal sample must be applied by the wearer or caregiver to the test area of the two biosensors 2 after selective dilution. In any of the above embodiments, the combination of the two biosensors 12 provides a diagnosis based on common viral (rotavirus) and bacterial (coliform) causes of diarrhea. As shown in FIGS. 1D and 1E, the diagnostic panel 10 may also include an integrated wiping mechanism 19 to remove excess excrement from the biosensor 2 and facilitate the use of -32- This paper size applies Chinese national standards ( CNS) A4 specification (210 X 297 mm) (Please read the notes on the back before filling out this page) Order printed by the Intellectual Property Bureau Employee Consumer Cooperatives of the Ministry of Economic Affairs 476640 A7-~---B7_______ V. Description of the invention (3〇 ) = Explain the result. In addition, the wiping mechanism 19 may include a sliding guard. The sliding buckle includes two flexible wiping wings that have no gap with the top surface of the biosensor 2 or have a small gap, and the diagnostic panel 1 can be manually slid down. Face to scrape excess feces from the surface of the biosensor i 2. In addition, the chromogenic biosensor described in U.S. Patent No. 6,001,556 and applied to detect rotavirus and coliform bacteria and selective other diarrhea pathogens described herein may be used in place of the plums of the diaper embodiments described above. ImmunoCard® STAT! Biosensor from Radiant Diagnostics. These films have the advantage of being thinner and smaller in area than other biosensor systems, and should be additional • Any other biosensor described in this article can be replaced or added to the examples above, including color and electrochemical properties Biosensor. The biosensor of the present invention may also include a biometric recognition system, including an enzyme or a tethered protein, such as an antibody immobilized on the surface of a physico-chemical signal transducer. For example, a biosalinity detector of antibodies raised against a strain can be used to detect that particular bacterial strain. In addition, it can be used to identify extracellular products of target bacteria (such as the strain (such as coliform)) product recognition elements (including antibodies and synthetic or natural molecules subject to ^ = ^ target bacteria. Can be used to detect (such as urine or excretion) Exemplary enzyme electrodes of phenol include tyrosinase-based electrodes or polyphenol oxidase electrodes. Please see the certificate issued to King Joseph et al. "U.S. Patent No. 5,676,820 and February 25, 1992 issued to Anthony PF Turner et al." Enzyme Electrodes for Organic Solvents, "U.S. Patent No. 5,091,299, both of which are proposed And methods are incorporated in this article. In any of the above examples, specific microorganisms can be detected directly, or by means of restraint -33- This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) ^ ---- ---- tl --------- (Please read the notes on the back before filling out this page) Printed by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 476640 No. 89114348 Patent Application Chinese Manual Correction Page (90 May 2015) ^ V. Description of the invention (3) An exemplary toxin, enzyme or other protein produced by an organism or an antibody (such as a monoclonal antibody directed against the organism). An exemplary biosensor is suitable for detecting the proteolytic enzymes described in US Patent No. 5,607,567 and the US Patent Toxins Nos. 5,496,452, 5,521,101, 5,567,301. In a non-limiting example of an exemplary diagnostic panel for vaginal infections, biosensors can be adapted to detect a variety of specialties that may cause bacterial vaginosis Type bacteria include Gardnerella vaginalis, Prevotella bivia, Bacteroides, Mycoplasma hominis, Mobiluncus. Biosensors can be used to detect non-specific types of cells that can cause vaginosis. Biosensors can also be used to detect fungi, such as Candida species, which can cause yeast vaginitis (Or yeast infection). Biosensors are also suitable for detecting protozoa such as Trichomonas vaginalis, which can cause difficult-to-open sexually transmitted diseases such as trichomoniasis, or other sexually transmitted diseases. Non-limiting examples of commercially available biosensors by Yu Zhenzheng G. vaginalis are FEM EXAM®G vaginalis PIP activity test cards, FEM EXAM®G vaginalis test The card is described in U.S. Patent No. 5,571,684. A non-limiting example of a commercially available biosensor suitable for the detection of bacterial vaginosis for an unspecified reason is the FEM EXAM® p (R) and Amine Test Card from Rittermas Concepts FEM EXAM® pH and amine test cards are described in US Patent No. 5,660,790. Other related Ritmas Concept patents and patent announcements include: 5,268,146; 5,416,003; 5,585,273; 5,897,834; and PCT Publication WO94 / 24306. Non-limiting examples of biosensors suitable for detecting Candida and Chlamydia are described in U.S. Patent Nos. 5,741,662 and 5,773,234 issued to Quiddell, San Diego, California, respectively. -34- This paper size applies to Chinese National Standard (CNS) A4 specification (210X297 mm) ---------- I (Please read the precautions on the back before filling this page),? Τ 476640 A7 B7_ 5. Description of the Invention (32) In other preferred embodiments, the diagnostic panel may include a biosensor suitable for detecting at least two of the following bacteria: various bacteria that can cause bacterial vaginosis, including Gardnerella vaginalis, Prevotella bivia, and similar Species, Mycoplasma hominis, Mobiluncus species. FIG. 9 shows an embodiment 920 of a non-restrictive pant, including an exemplary diagnostic panel 960 to detect various causes of vaginitis. The diagnostic panel 960 shown in FIG. 9 includes five sensor elements 962, 964, 966, 968, and 970. The above-mentioned sensors may be suitable for being used alone to detect one or more causes of vaginitis, or to be combined with one or more Multiple other sensor elements are merged. Sensor element 962 is suitable for detecting p Η, sensor element 964 is suitable for detecting the presence of amine, sensor element 966 is suitable for detecting G. vaginalis, and sensor element 968 is suitable for detecting Candida In particular, the sensor element 970 is adapted to detect Trichomonas vaginalis. The sensor elements may be of any suitable shape and any suitable configuration and are not limited to the square sensor arrangement shown. The combination of sensor elements 962 and 964 can be used to measure non-specific causes of bacterial vaginosis. An early study of bacterial vaginosis (BV) included the pH value of vaginal fluid in women with BV and unaffected patients. For comparison, see Am. J. Obstet. Gynecol. Gardner HL et al. 69 · 962 (1955). All women with positive BV in the study were judged to have a vaginal fluid pH 値 greater than 4.5, and 91% of them had a vaginal fluid pH 大于 greater than 5.0. The current study adjusted the p Η lower limit 为 to 4.7. In addition to pH, Amesel, R., et al. Developed three other BV indicators in Am. J. Med. 74: 14-22 (1983): vaginal fluid homogeneity, olfactory test (treated with strong base, then olfactory The test detects amine odor), and the appearance of clue cells. If there are two indications (pH and amine), the test is highly in line with -35- This paper size is applicable to China National Standard (CNS) A4 (210 X 297 mm) (Please read the precautions on the back before filling this page) Binding i Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 476640 V. Invention Description (33) Results obtained from all four instructions of BV. Better pH indicator A: bromine test blue, molybdenum test blue, brook cresol green, brook (please read the precautions on the back before filling out this page) cresol purple, murray blue, bright yellow, and Is yellow. A particularly good pH indicator is nitrate. When the quaternary ammonium roots are combined, when the pH is raised, it changes directly from yellow-green to blue in a narrow pH range of about 0.1 pH units, and the transformation is concentrated at η 4.7. "', P. The ammonium radical can be any positive root capable of exerting ionic attraction with the negative root in the indicator. The preferred quaternary ammonium radical is a lower alkyl ammonium radical, wherein the alkyl radical is C 1 -C 4 Basic root, particularly preferably trimethylammonium.

An olfactory test by Amsel's criteria was derived from a study by Feffer et al., The New England Journal of Medicine, 298; 1429-1434 (1978), where 10% KOH will be special when added to vaginal fluid samples from women with BV. Fishy amine odor, caused by amine salt test volatiles present in vaginal fluids of women with BV. Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs, using the amine test to identify amines that are volatilized by strong alkalis and amines that are not volatilized by strong alkalis. Among them, solid strong alkalis that can be used for samples and liquid samples can be used in the same device An indicator that can only be used for the vapor emitted by the sample. Therefore, the sample is first exposed to a strong solid base and then applied to two indicators, one of which changes color regardless of the presence of volatile amines, and the other indicator changes color only when volatile amines are present. The choice of a solid strong base that releases gas flakes is not important and can be changed. Generally, strong bases and alkaline earth metal aluminates, carbonates, and hydroxides can be used. The most commonly used is sodium aluminate, sodium carbonate, or magnesium hydroxide. For best results, sodium aluminate is particularly preferred. 36 ^ Paper size Gu Jin Lai Jiaqun (CNS) A4 specification (2i0 X 297 mm) 476640 Printed by A7 B7, Consumer Cooperative of Intellectual Property Bureau of the Ministry of Economic Affairs 5. Description of the invention (34) Can be used and exposed to amines (preferably the original It is an amine in an acidic fluid sample.) Any indicator that changes color. Bromocresol green is an example and can be used here and p Η test. Other examples are bromophenol blue, bromocresol purple, bromochlorine test. Blue, Shi Xiaohuang and various other indicators. The sensor elements 962 and 964 may include the above-mentioned Ritamasen ’s EXAM® pH and amine test card sensors to detect non-specific causes of bacterial vagin〇sis, which uses US patent 5,91〇, Technique No. 447. The sensor element 966 is suitable for detecting G. vaginalis. In 1988, a report by Thomson et al. (ObStet. Gynec.l., 7l (4): 606 (1988)) showed that: Bacterial enzyme activity, especially proline proteases, may be an appropriate indicator of BV. Proline protease provides the action of a hydrolase, "a hydrolase, as used herein, refers to a catalyst capable of splitting a compound into fragments by adding water. 舲 A sample is contacted with a solid phase conjugate for measurement. This solid phase The conjugate is susceptible to cleavage by the hydrolase during or after the indicator is in contact with the sample. A cleavage group in the conjugate that is partially or completely released from the conjugate by the action of the hydrolase A detectable change is effected when it is in effect. A conjugate refers herein to an information group that is coupled to a matrix residue but can be cleaved or dislodged when exposed to a catalytically active hydrolase that has been detected. The "information group" or the generic "labeling group" refers to the part that can be hydrolyzed and released from the matrix residue by a hydrolase and can react with an indicator to generate a detectable change in the free form. These information groups include, but are not limited to, the following: test, tea test, aromatic amines, amino acids, their derivatives, and the like. A particularly preferred embodiment is the use of naphthylamine and its derivatives or analogues as a beam ιφΤ a (please read the precautions on the back before filling this page). -------- Order ----- ---- This paper is standardized by Guan Tsuan-Xuan (CNS) A4 (21_〇_ 297 mm) -37- / 0040 A7 B7 V. Description of the invention (35) If the relevant hydrolase is outside the release information group Any other point makes the hydrolase itself unable to actively release the information group when the conjugate is hydrolyzed. One or more co-hydrolyzing enzymes that only interact with the relevant hydrolase can be used to measure enough to release the #interest group. Therefore, the auxiliary hydrolase must be a hydrolase that can directly release the information group from the 70 good conjugate and only release the information group from the cleavage product produced by the related hydrolase. The following is an example of the reaction sequence used. First, the relevant hydrolase that cannot directly release the information group is specifically hydrolyzed by one or more bonds located in the conjugate, thus releasing a fragment of the molecule containing the inactive information group. Then, one or more auxiliary hydrolase releases the information group by hydrolyzing the bond between the substrate residue fragment and the amino group in one or more steps. The net effect of the above reaction sequence is that information groups will only be released when the fmeguanase is present in the sample. To demonstrate the practice of the present invention for detecting the activity of a proline blowing enzyme, a sample is placed in a device comprising a first and a second solid support, the first solid support being a Mylar® polyethylene laminate, An L-propyl-/?-Naphthylamine and l-propyl · methoxypyrrolidine can be deposited on the vial-L-propyl-fluorenyl gallamine co-synthesis; the second solid support is A Mylar® polyethylene laminate with a Fast Garnet GBC color change indicator that can detect changes when /?-Amidamine is deposited. The sample is placed in the device in such a way that the sample contacts the first and second solid support portions, and any /?-Amidine released by the proline amylase activity in the sample can diffuse through the sample to the second solid support portion. . Fast Garnet GBC then observed to indicate that there are g per specification in the sample -38- This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) (Please read the precautions on the back before filling this page) -Installation -------- Order -------- Φ Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 476640 A7 B7 V. Detectable change of invention description (36). The conjugate can be used in a matrix of a water-soluble polymer such as hydroxypropyl cellulose. Fast Garnet GBC indicator can be used in water-insoluble matrix of ethyl cellulose containing penetrants such as magnesium chloride :. The sensor element 966 may include the fem EXAM®G vaginalis PIP activity test card of the above-mentioned Ritmas Concept Company, which uses US Patent No. 571,684. The sensor element 968 is suitable for detecting Candida species, and it has been found that an enzyme-active Candida albicans protease is present in vaginal fluid with vulvar candidiasis. Further understanding: the presence of aspartic protease with enzyme activity in the sample or sample can be used as a marker for detecting and diagnosing candidiasis. Therefore, a method has been developed for detecting candidiasis by determining whether an aspartic protease having an enzyme activity is present in a sample. In this method, the sample (such as vaginal fluid) is in contact with a solid support, and the solid support that the sample is in contact with is fixed with an information enzyme (that is, a signal generating enzyme), and the information enzyme is fixed on the solid support. Therefore, it can be released from the solid support when the aspartic protease with enzymatic activity (if the aspartic protease with enzymatic activity actually appears in the sample) acts. The sample in contact with the solid support is combined with a fingerless agent. This indicator is any chemical species that is susceptible to visible or detectable changes (such as color changes) when the information enzyme functions. If the indicator undergoes a detectable change after contact with the sample, an aspartic protease with enzymatic activity appears in the sample and can be judged to have candidiasis. The term "information enzyme" or "labeling enzyme" as used herein refers to a signal-generating enzyme, that is, an enzyme whose activity will cause a detectable change. This information enzyme contains but not • 39- This paper size applies to China National Standard (CNS) A4 (210 x 297 mm) (Please read the precautions on the back before filling this page) Binding -------- -Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs, printed 476640 Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs, A7 ______ B7_— Jade, Invention Description (37) Limited to the following: peroxidase, linase, oxidoreductase, Degassing enzymes, transferases, isomerases, kinases, reductases, deaminase, catalase, urease, glucosidase. A preferred information enzyme is catalase, such as horseradish catalase. The information enzyme is immobilized on a solid support, which is an insoluble polymeric substance, an inorganic or organic matrix, a colloid, an aggregate, a precipitate, or a resin ', so that it can be released when the presence of a hydrolytic enzyme is detected. Out of information enzymes. Preferred solid supports include, but are not limited to, the following: cellulose, leptose, dextran, polypropionate, polypropionate, or derivatives thereof, chitin, agarose, and oxygen Acrylic beads and polymerizable starch, starch, collagen, keratin, elastin, cowhide powder, bacterial cell wall polysaccharides or fragments thereof, nylon, polyethylene terephthalate, polycarbonate, and controlled glass . The zymase is immobilized on a solid support using a conventional method and procedure known to those skilled in the art. As used herein, "indicator" refers to any chemical species that undergoes a detectable change due to a reaction when an enzymatically active hydrolase is present in a sample or sample, or due to an increased reaction. The detectable change generated indicates the presence of an enzymatically active hydrolase in the sample or specimen. The preferred indicator is a visual indicator, especially a color indicator (you can also see the wheat color). 'Including when the test is done. 1. Do not connect to the active hydrolase. When the solid support part releases and captures and acts, it forms a color in the original colorless material. In addition, the letter from G + · Xinxiu catalyzes the formation of sulphur but sulfone when it is released from the solid support by the action of hydrolytic enzymes. It is firstly aluminous, phosphorescent, bioluminescent, chemiluminescent, or thunder. p is Λ% to bluff. In addition, the information enzyme may be generated (please read the precautions on the back before filling this page). Install tr --------- ·

476640 A7 B7 V. Description of the invention (38) Other visual or detectable signals, such as a blocked, stuck, deposited or cleared area. (Please read the precautions on the back before filling out this page.) Many hair color indicators (ie hair color substances) and other types with similar effects can be used with horseradish peroxidase as the information enzyme to become visual indicators. A preferred chromogenic indicator according to the present invention comprises a hydrogen peroxide and a chromophor, including but not limited to the following: tonka, 2_2, -plow-and-bis (3-ethyl-benzene well Oxazoline-6-sulfonic acid), tetramethylbenzidine, phenol, 4-aminoantipyrine, and 4,5-dihydroxyfluorene-2,7-disulfonic acid. A particularly good color indicator is a mixture of hydrogen peroxide, tonka, and a hair color, which is colorless in the reduced state and dark blue in the oxidized state. The sensor element 968 may use the technology described in US Patent No. 5,416,003. Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economics The sensor element 970 is suitable for detecting trichomonas vaginalis. A method for detecting trichomonas vaginalis by measuring the presence of an enzyme-active thiol protease in the sample is provided. The method includes: (a) contacting the sample with a solid support, and the solid support is immobilized with an information enzyme, so that When the thiol protease with enzymatic activity functions, the information enzyme will be released; (b) after an indicator has contacted the solid support, it will be merged with the sample, and when the information enzyme is active, the indicator is prone to have &quot; ί Measure the wheat and (C) observe the sacrifice whether the 7JC agent has detectable changes. This detectable change indicates the presence of thiol protease with enzymatic activity in the sample, thus the occurrence of Trichomonas vaginalis. As needed, one or more sensors 962, 964, 966, 968, 970 can be replaced by a pregnancy test sensor. This sensor can be a chromatographic strip. For example, 丨 introduced in 988 a The patented new type of over-the-counter pregnancy test (Clearblue Easy), which uses sandwich-type dyed microspheres -41-This paper is sized for China National Standard (CNS) A4 (210 X 297 mm) 476640 A7 B7 V. Description of Invention (39) to provide a single step test. To prepare for the test, small dark blue stained microspheres (0) are first coated with antibodies to HCG (human chorionic gonadotropin) (AbD; microspheres (O-Ab!) Are dried on a portion of nitrocellulose strips A secondary antibody (Ab2) to HCG is fixed on the strip of the other segment. When this strip is used, the urine is moistened at one end and the urine is moved by capillary action, and the monitoring microspheres (0-Ab 1) will be obtained and Taken downstream; any HCG in the urine reacts with Ah on the microspheres (O-Abi-HCG). When the flow reaches the fixed Aby 1, the microsphere system has been stained with HCG (0 · AVHCG) An HCG sandwich (0-Ab! _ HCG- Ab2-1) obtained from Ab2-1 results in a blue line, which represents a positive pregnancy test. Another fixed protein (Ab: r 1) line is located at Further downstream, the immobilized protein (from 3- 1) takes uncoordinated O-Abi as (O-Abi-AbylM has nothing to do with HCG) to form another blue line, and the other blue line serves as a positive program control group If the second line is not formed, the test result is invalid. It also has the household test of L Η (luteinizing hormone) and the phase of streptococcus a and chlamydia Clinical tests, yet other sources include: human chorionic gonadotropin (HCG), common infectious diseases and DAU (urine drug abuse), in which the principles of this system using a laboratory chromatography analysis of single analyte testing.

Carter-Wallace Home Pregnancy Test First Response® uses a single microsphere (~ 1 micron) coated with hCG antibody and an extremely small (&lt; 50 nm) red gold sol coated with another hCG epitope particle. When mixed with a urine sample ', if the sample contains hCG, the particles coagulate and a red block is generated. The mixture is poured through a pink filter which scoops the red block. For negative urine, uncondensed red particles pass through the filter without discoloration. -42- This paper size is in accordance with China National Standard (CNS) A4 (210 X 297 mm) (Please read the notes on the back before filling out this page)-Binding · Printed by the Intellectual Property Bureau of the Ministry of Economic Affairs and Consumer Cooperative 476640 A7

V. Description of the invention (40) Another immunoassay method printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economics includes applying an aqueous solution containing an analyte antigen to one end of a multi-zone test strip device, so that the solution acts with capillary action along the The strips are moved and the zones are arranged such that solution (a) first contacts and reconstitutes a dry, diffusible labeled component that contains colloidal gold conjugated to an antibody against the analyte antigen and then b) contacting and reconstituting a dry, diffusible biotinylated secondary antibody against the analyte antigen, thus forming a diffusible sandwich reaction product. The reaction product diffuses along the strip along the solution and enters a zone containing a scavenging component, which contains a latex and an avidin complex. Avidin collects the reaction product by reacting with its vitamin H portion. Therefore, gold Particles are collected and concentrated in the detection area for visual determination. Techniques that can be used for composite analyte analysis can therefore be used in the present invention, including but not limited to: microbeads labeled with antibodies, Silas (TR) surface analysis, or thin film-based biosensors. In practice, an array of sensors can be placed on a surface that will contact an appropriate sample, including, but not limited to, urine, saliva, sweat, and vaginal discharge. Each sensor responds to each analyte and generates a detectable signal, which may be only a color or refractive index change, or may include an electrical signal change due to a current flowing through a biosensor film. For example, antibodies to appropriate hormones can be immobilized on the surface of Silas optical wafers by methods known in the art. These wafers can then be separated by conventional patterns and arranged on a detection object (such as a pant). Similarly, these antibodies can be immobilized on microbeads and arranged in a lateral flow measurement device suitable for one of the urine or saliva matrices. And, multiple reagents can be used in an array at the same time -43- This paper size is applicable to Chinese National Standard (CNS) A4 (210 X 297 mm) (Please read the precautions on the back before filling this page) -Pack ---- Order --------- · Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 476640 A7 ----- B7____ V. Invention Description (41) Provide readings for all analytes. Similarly, it can be used in conjunction with hormones to detect other analytes, including biomarkers for other target conditions (such as infection, osteoporosis, etc.). The SILAS ™ or SILICON analytical surface technology from Biostar in Bod, Colorado is a known method for detecting specific target molecules. Biostar's patents for this technology include: U.S. Patents 5,955,377, 5,869,272, 5,639,671, 5,629,214, 5,541,057, 5,482,830, 5,468,606, 5,418,136. This thin film-based technology has been successfully used in the development of diagnostic tests To detect bacterial and viral antigens from group A streptococcus, group B streptococcus, chlamydia, and influenza A and B (optical immunoassay (0Ia®)). The wafer contains a silicon support with an optical coating and an attachment layer. This wafer surface technology can directly visually detect the physical change in the optical thickness of the molecular film. This thickness change is due to a specific analysis on the surface. Caused by things. When the substrate is added, the binding event is enlarged and the surface thickness of the molecular film is increased again. This thickness change changes the reflected light path and visually recognizes a color change. A slight change in optical thickness will produce a noticeable visual discoloration, and a positive result will appear as a purple dot on a roughly golden background. When no target appears in the sample, there is no restraint, so the optical thickness remains the same, and the surface remains the original golden color, showing a negative result. Therefore, in the first type, SILASTM technology is used in a device for detecting the occurrence of an analyte being targeted. The device includes a substrate having an optically active surface, and the optically active surface responds to impacts on the substrate. The first light is a first color. This first color is defined as the spectral distribution of the emitted light. The substrate also shows a second color that is different from the first color. Standard (CNS) A4 specification (210 X 297 mm) (Please read the notes on the back before filling out this page) -------- «— — — — — — I— -44-

/ UO4U V. Description of the Invention (42) A combination of light wavelengths different from the combination of the first color, or a different spectral distribution, or one or more wavelengths of sufficient intensity different from that of the first color) 'When When an analyte appears on the surface, it appears in a second color in response to the same light. The optical moving surface is a surface that participates in generating optical effects, so that a portion of the light impinging on the surface is changed. This optical active surface is suitable for responding to polychromatic light (such as white light) and monochromatic light (such as laser light that can be inherently polarized). The device of the present invention preferably generates a color signal that causes the background interference color of the unreacted test surface to be strongly contrasted with a reacted surface. In detail, the present invention is characterized in that the substrate has a similar device with an attachment layer consisting of a chemical selected from the following: a tree polymer, a star polymer, a molecular self-aggregating polymer, a polymer Siloxane, and film forming latex; the substrate itself is composed of a material selected from the following: monocrystalline silicon, amorphous silicon on glass, amorphous silicon on plastic, ceramic, polycrystalline silicon, and more And the substrate may have an optical film made of a material selected from the group consisting of: nitrided hard, broken / silicon dioxide composite, titanate, diamond, #oxide, and silicon carbide. The substrate is selected from glass and plastic and contains a layer of amorphous debris on the surface, thus creating an optically active surface; the optical master record includes single crystal silicon or metal; the substrate in the metal further has a layer of amorphous silicon; a The receptor layer that can sense an analyte is provided with a specific binding body for the analyte; the receptor layer is composed of a material selected from the group consisting of an antigen, an antibody, an oligonucleotide, a chelating agent, * , Bacteria, bacterial hair, bacterial flagellum material: acid, polysaccharide, lipid, protein, water compound, metal, virus, thorium-45- This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) ) (Please read the notes on the back before filling out this page) -------- Order --------- Φ. Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs

4 / (3b4U A7 B7 V. Explanation of the invention (43) and its receptors; and when viewed visually, the first color has a golden appearance, and the second color has a purple or blue appearance. In addition-related types This technology is related to a method for detecting a related analyte in a sample, including the following steps: providing a thin-film optical immunoassay device having a substrate having an upper surface and a lower surface, and on the upper surface An unlabeled antibody layer bound to the substrate is supported on the substrate, and at least-the layer contains the analyte from the sample. The analyte-containing layer supports at least the -enzyme layer having co-depleted complexes with the analyte; contact Enzyme conjugated with a sinking agent; culture for a period of time sufficient to precipitate the product by shaking the precipitant with the enzyme phase; and optically measure the mass change of the enzyme co-light layer 卩 unlabeled antibody layer to indicate the test The amount of analyte in the sample. Preferably, the enzyme conjugate has an immobilized peroxidase or an antibacterial antibody _ horseradish perfase complex; or the enzyme conjugate is alkaline phosphatase and contains a bacterium Corpus callosum alkaline phosphatase complex And the precipitating agent is a substrate containing 5 bromo-4 gas-3 4 podoylarsinate. The pant 920 in FIG. 9 includes a composite top layer as described in Van Dibor's US Patent No. 6,04,893, An apertured film containing a strip of nonwoven material joined to the apertured film along the sides of the pantilin. The components of the top layer can be joined in any suitable manner, such as shown in Figure 9 (most circles arranged in a sinusoidal pattern) · Shape-welding). The sensing element 962, 964, 966, 968, 970 can be attached to the 924 heart-wearing surface of the top of the panty pad. The sensor can be attached to the region of the panty pad corresponding to the wearer's vaginal position The sensor can be attached by any attachment or bonding device (such as adhesive) known in the art. In addition, the top layer 924 can contain at least one (please read the precautions on the back before filling this page) n I nnnn It》 一 «» 4 «ai · tl an · 1 nn I-Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs -46-476640 V. Description of the invention (44) Holes and sensors can be attached ,,, /, ', and the layer openings are corresponding to the area below the absorption core. All parts can be-positive or negative marking nature, as shown in Figures 9 and 9A refer to the presence or absence of a test analyte in a quantity exceeding a specific low limit. Another 5F can be passed through the diagnostic panel shown in Figure 10 The display provides a color production indicator for the amount of test analyte, and the color darkness on the sensor element can be compared with the comparison table ι09〇 'as shown in Figure 11 to indicate the presence of test analytes. There are several types The Shida I type comparison table includes, but is not limited to, a card that is packaged with the sensor # object &amp; or located on the outside of the package. The sensing device may be covered with a covering portion 980, where the test reagent appears : Prevent the test reagent in the sensor from touching the wearer's body. Preferably, the wind-covered 4 980 * color and flexible 'will not interfere with the wearing of the article if the article is of the type worn near the wearer's body. The cover 98 may be made of any suitable material, such as plastic, SARAN (R) packaging, MYLAR @, or the like. The cover 980 may have an opening to allow the body fluid to contact the sensor, or may be non-opening. If a covering portion 980 is used, it may be necessary to provide a fluid transport element, such as a woolen, 'field bar' 982, which is placed under and / or on the side of the sensor to allow the relevant body fluids to contact the sensor. Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs Figure 12 shows an example 1220 of an unrestricted sanitary napkin including an exemplary diagnostic panel 1260. The sanitary napkin 1220 shown in Fig. 12 also has a plurality of circular welds arranged in a quilt-like pattern on the body surface. The sanitary napkin 1220 also has corrugated wings or wings. It should be understood, however, that the present invention can be used with tampons having many other suitable configurations. -47- This paper size is in accordance with Chinese National Standard (CNS) A4 (210 X 297 mm) 4 / 〇ϋ4ϋ 5. Description of the invention (―45) Figure 1 3-1 5 shows an exemplary diagnostic panel 136〇 Non-limiting interlabial device embodiment Π20. The interlabial device 1320 includes a top layer 1342, a bottom layer 1338 which is a top soil layer, and an absorbent core 13 44 located between the top layer 13 42 and the bottom layer 1338. This embodiment of the interlabial device also includes a handle 1352 'for the user to hold the device for insertion and removal as needed. Illustration In the case of other objects, the device may be of various suitable constructions. Fig. 16 shows how the user holds the interlabial device 1320 and inserts it into the space between the wearers 'labia.' Fig. 17 shows the relative position of the interlabial device and the wearer's body. The body part w of the wearer shown in FIG. 17 is described as follows: bladder b, clitoris c, urethra U, labia minora N, labia majora J, vagina v, vaginal opening VI, anus A, hymen ring, and large intestine I. The interlabial device 1320 is inserted and worn between the wearer's labia minora N and the labia majora J and blocks the wearer's vaginal opening νι without entering the vagina beyond the hymen ring. That is, when the device is worn, the interlabial device 1320 is located at least partially in the anterior cavity surrounding the labia minora. Ideally, the interlabial device 1320 is kept as close as possible to the internal surface area of the wearer's labia minora ν and the labia majora J, which will ensure that the interlabial device 1320 intercepts the wearer's body emissions as much as possible. In the specific embodiment shown, the interlabial device 1320 is preferably at least in place in a folded configuration, causing the interlabial device to exert a slight lateral pressure on the inner surfaces of the wearer's labia majora, labia majora, or both . In addition, the attractiveness of the naturally wet labial surface to the top layer 1342 holds the product. As needed, the top layer 1342 may have a biocompatible adhesive to help the top layer 1342 adhere to the medial surface of the wearer's labia. In addition, in other embodiments, it does not have a single detector or as shown in Figure 1 3 _ -48- This paper size is applicable to China National Standard (CNS) A4 (210 X 297 mm) (Please read the note on the back first? Please fill in this page for further information.) Install tr --------- Printed by the Consumers' Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs 476640 Printed by the Consumers ’Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs A7 B7 V. Description of Invention (46) 1 6 The tf includes a plurality of diagnostic panels 136 ′ located at the center of the 1342 central detector. Instead, the interlabial device 1320 may have detectors in various configurations. In one non-limiting example, the interlabial device 132 may have separate detectors or diagnostic panels. For example, an interlabial device can have two detectors, one detector can be directed toward the front of the interlabial device (for example, to detect the cause of adult incontinence or a urinary tract infection), and one can be directed behind the device (for example, to detect the vagina). Infection) ° Other types of absorbent articles described herein are also suitable for the possibility of placing multiple detectors in a variety of different locations. However, in the case of interlabial devices, this configuration is believed to be particularly advantageous, as the interlabial device is used in close proximity to the wearer's urethra and vaginal opening '. This proximity action makes the relevant body substances more likely to come into contact with appropriate detectors. In other embodiments, labial devices with more than one detection device type or location may be sold in groups to detect more than one condition. In other embodiments, 'more than one type of article described herein can be sold in groups to detect more than one condition. Figure 18 shows a non-limiting tampon 1820 embodiment including an exemplary diagnostic panel 1860. The biosensor 60 used in the present invention may include one or more "proactive sensors", which is particularly effective in the embodiment of detecting a target bioreactive analyte before clinically observable health symptoms begin. "Proactive sensor" in this article refers to a sensor that can detect changes or signals on the wearer's body (i.e., the skin) or in body material (i.e., inputs). These signals are related to the upcoming or potential The health or skin-related events are directly related or at least related, and a proactive sensor may respond to one or more specific inputs as described above. (You can understand all the relevant descriptions of "Biosensor 6 0" can also be applied to the objects shown in the figure -49- This paper size applies to China National Standard (CNS) A4 specifications <210 X 297 mm) ---- ------ Install -------- Order --------- (Please read the precautions on the back before filling this page) 476640

Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 5. Other sensors of the invention description (47), such as diagnostic panels 96, 12, 60, 1360, and 1860). The proactive sensor 60 may detect an upcoming event, or detect a parameter that is directly related or at least related to the upcoming event, especially a systemic or skin health event or condition (that is, a Indications or symptoms of clinical observation). Imminent events that can be detected or predicted by the proactive sensor 60 of the present invention may include: diarrheal disease, skin irritation or rash (including candidiasis), and / or other types of illness or medical condition of the wearer , Such as a parasite infection. Detected biological analytes can be one or more steps to remove clinical symptoms that actually occur. For example, a biosensor can detect potential precursors to the conditions described above (such as excretion of the skin before causing stress proteins). (Contaminant 'stress proteins appear before skin irritation can be observed clinically). A parameter related to an event is any measurable input, such as one or more of the above signals (ie, a signal caused by fecal matter or the wearer) related to the occurrence of an event in the whole body reference frame. Proactive sensors in objects can measure one or more different inputs to predict events. For example, a proactive sensor 60 can monitor Candida albicans in feces and residual coliform bacteria on the skin (that is, detect residual pollution), both of which are signals that can appear before skin irritation. In the embodiment of the biosensor that does not generate an easy visual signal (such as discoloration), the biosensor 60 may include a signal electrical measurement converter that is in communication with the biometrics component, and will come from the biometrics component. Physical signals are converted into signals that can be used by the wearer, caregiver, or object component (such as an actuator). Exemplary signal electrical measurement converters may include electrical signal electrical measurement converters known in the art (including potential, current, and conductivity signals -50-This paper size applies to China National Standard (CNS) A4 specifications (210 X 297 mm) ------------------- Order-I--I --- (Please read the notes on the back before filling out this page) 476640 Patent No. 89114348 Amendment page of the Chinese manual of the application (May 90) A7 _ _____ B7 V. Description of the invention (48) Measuring converter), optical signal electrical measuring converter (including fluorescence, bioluminescence, total internal reflection resonance, and surface electricity Plasma resonance), thermal signal electrical measurement converter, and acoustic signal electrical measurement converter. A power source (such as a miniature 3 volt meter battery or a printed thin film lithium battery) can be connected to the biosensor 60 to provide any required power. The response factor test in the following test method can be used to measure the effectiveness of the biosensor of the present invention. The response factor describes the response of the biosensor when exposed to a fecal test substance and the response of the biosensor to a physiological saline solution. Ratio and can be used to evaluate the sensitivity of the biosensor to bioactive analytes that are scheduled to be preferentially found in excreta rather than urine. The biosensor fork of the present invention preferably has at least 2, 3 or 5, when it is exposed to fecal test material or urine in an aqueous solution having a concentration of 1 g of a physiological saline solution and 1 g of fecal test material. A better response factor of at least 丨 0 and more preferably at least 20 (using physiological saline to represent most background input signals such as those found in natural soils such as aqueous body fluids). The biosensor is able to clearly discern the emergence of excreta and the presence of physiological saline solution for a target bioactive analyte system for excreta. Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs (please read the precautions on the back before filling this page). One way to detect fecal matter is to detect fecal odor, which is a common substance in feces. The concentration of skatole in the urine is about 18 micrograms per gram of excretion, and the skatole value in urine is significantly lower. Scopolamine is usually a product of microbial decomposition from tryptophan metabolism in the intestine. In a preferred embodiment of the skatole detection biosensor, the biosensor contains genetically engineered microorganisms to absorb skatole and other substances. For example, the measurement of skatole specific substances can be measured by oxygen consumption during the absorption process. Microorganisms that are absorbed and suitable for detecting skatole include Acinetobacter baumannii -51- This paper standard is applicable to China National Standards (CNS) A4 specification (21 × 29 &lt; / mm) Staff of Intellectual Property Bureau, Ministry of Economic Affairs Consumption cooperative printed clothing 476640 A7 ___ B7_____ 5. Description of the invention (49) TOI36 (FERM P-12891, Japanese Patent Publication JP05304947) and Bacillus sp TOI41 (FERM P-12914, disclosed in Japanese Patent Publication JP05304948). Appropriate biosensors that include this microorganism, such as Mikrobielle Sensoren from Institut fur Chemound Biosensorik, Munster, Germany. If a microorganism is used in a biosensor, it can be captured, adsorbed, crosslinked, encapsulated, covalently Attachments, any combination of the above, or the like are fixed in the biosensor by techniques known in the art. Also, fixation can be performed on, for example, many different substrates known in the art. In a particularly preferred embodiment, the immobilization matrix may be selected from the group consisting of a polymer-based substance, a hydrogel, tissue paper, a nonwoven material, a woven material, and a silicon semiconductor. In a specific embodiment, a biosensor including any biosensor embodiment may include, be configured in, or be operatively connected to a microchip (such as a silicon chip), a MEMs (ie, a micro-electrochemical system) device, or Integrated circuit. Microchip-based biosensors are conventionally known as "biochips." Regardless of the sensor, the microchip may be included in any of a variety of quantities or combinations suitable for detecting the analyte (s). Most sensor components in the array have similar or different sensitivities, kinematics, and / or target analytes (ie, labeling). And each biosensor in this array can provide different types of signals, including those described herein. These types can be connected to different actuators and / or controllers. Moreover, each biosensor in an array can be operated independently or connected to any number of other sensors in the array (such as parallel, Combined or typed). Biosensor 60 can be configured and / or operatively connected to disposable objects (such as diaper 20 in Figure 1) exposed to any input of biosensor scheduled detection -52 -This paper size_Chinese National Standard (CNS) A4 specification (21G X 297) (Please read the precautions on the back before filling in this page) 476640 V. What is the description of the invention (so)? 20 is mainly used to represent this description object. All descriptions about the biosensor are also applicable to other illustrated objects. In the present invention, "operability 1% connection" means that when the biosensor 60 detects an input, Then pass: a communication device of a certain part of the object 20. The biosensor can be connected to another part of the biosensor 60, another biosensor 60, a controller or a component of the object 20 Some other parts are isolated and operatively connected. "Operatively connected" may include, for example, communication devices such as via wires or components, via an electrical connection that sends signals such as radio frequency, infrared, or another transmission frequency communication. In addition, The biosensor 60 can be operatively connected through a mechanical connection such as a pneumatic or hydraulic connection. In the diaper shown in FIG. 1, the biosensor 60 can be located at the front waist region 36 and the rear waist region of the object 20. 38 or sacral region 37, and can be integrated, adjacently arranged, joined, or include a portion of the base 22, top layer 24, bottom layer 26, and absorbent core 28, side panels 30, foot cuffs 32, a waist feature 34, One fastening system 40, longitudinal edge 50 or end 52, etc. In a specific preferred embodiment in which the target biological analyte is related to body excreta, the biosensor 60 can be disposed in the object 20 胯 area to maximize the contact of the body excreta with the biosensor 6 〇 Probability. In other preferred embodiments where the biosensor is suitable for detecting or measuring a target analyte agent on the wearer's skin, the biosensor 60 can be configured on the top layer, flanging, a waist feature, An excrement receiving capsule, fixture, or any other part of the object that comes into contact with the wearer's skin during the procedure. In certain embodiments, the biosensor can also be combined with liquids or other skin care in the object The biosensor 60 can be integrated with the object 20, or it can be worn by a caregiver or wearer (please read the precautions on the back before filling out this page)-equipment ---- 1 --------- Printed by the Employees' Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs-53- Printed by the Consumers' Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs A7 ':-* ------ B7____ 5. Description of Invention (51), female. The biosensor during the wearing of the object can also be at least two away from the object, be detached, and adhere to the skin of the wearer. The biosensor can be attached permanently or detachably (for example, via a mechanical fastening system, such as Velcro ™ or water-soluble adhesive: a supporting structure, including adhesive tape, cellulose or synthetic fabric, non-woven fabric: Bumps, films, fabrics, foams, and the like. Also, the biosensors 60 can be fully housed in objects such as object 20, or they can have a storage portion in the object to access the required input. And has another part such as the sending department located in or outside the object. The biosensor 60 can be located outside the object 20 but still operatively connected to a part of the object 20, making the biosensor 4 60 can detect an input external to the object 20 and provide a signal to a controller and / or actuator. In some embodiments, the biosensor can be isolated from the object, such as via an adhesive or Other devices known to the art are separated and added to a part of the wearer, and / or may have one or more components separated from the object. In some embodiments, a wiping device or element may be provided to enable wear. Or protector self biosensor 60 Clean enough feces to visually evaluate or read the signal (especially for the biosensor embodiment that provides this signal). The wiper element may include a fabric (cellulose or synthetic), non-woven disposed in the object High bulk, film, foam, rigid or semi-rigid rubber roller-like elements, and the like, and make the element useful for cleaning the biosensor display. The wiping element can be at least partially attached to any conventional device of the art The object is near a component of the biosensor 60 (such as the top layer, the bottom layer, and the absorbent core). The wiping device may contain water or any conventional cleaning aid as needed to facilitate cleaning of the wearer or the biosensor display. 54 · The scale applies to China National Standard (CNS) A4 (210 X 297 mm) ^ -------- ^ --------- (Please read the precautions on the back before filling this page ) Α7

Printed by the Consumers' Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs η / υυ ^ -υ 5. Instruction (52) In a specific preferred embodiment, the object 20 may also include an actuator. The "actuator" in this article is Refers to a device containing "potential," and a device for converting potential into: or. The "dynamic response function" of the device ° the potential of the actuator can include storage or t flb or storage material. The actuator can therefore be carried out or activated by converting potential energy into kinetic energy, or by releasing or transporting-material- Response function. The "response function" in this article is defined in the present invention as a component of fecal matter, wearer, object or its component, or the signal of wearer or caregiver. Examples include moisture, electrolytes, enzymes, volatile toxins, field bacteria, and blood. The components of the wearer may include skin, external genitalia, and vulva, anus, anal sphincter, and the like. The components of the article may include feet, side hem or other fecal obstruction and / or containment components, side ear I5 base,-absorbent core, an acquisition component, a fastening system, longitudinal or end edges, etc. Potential energy can be stored as mechanical, electrical, chemical or thermal energy. "Kinematic energy" herein refers to the work or response function as described above (such as' inflated by the compression device, the rotation of the twisted device, the gelatin that moves during the phase change, the application or treatment of the skin, the inhibition of enzymes, and the adjustment of pH Etc.) of energy. / When triggering to generate a 1-body structure to capture body matter, for example, it includes: for objects, and finally responds to body matter. Retrieving body material, wiping the wearer's skin, or treating the skin with skin care compositions, anti-microbiotics, or enzyme inhibitors are all response functions for body objects or tooth wearers. Adjusting the object's geometry-two-dimensional, two-dimensional, or three-dimensional) or physical properties (such as bending modulus: shape, etc.) are examples of functions that can be performed on objects. Announcement // or the wearer has happened or is about to happen_ the event is purely for the present invention ------------ ^ 1 ^ · 装 --------- order · ---- ---- f Please read the Zhuyin on the back? Please fill in this page again for matters) -55- 476640 Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs A7 ---------- BZ ____—— V. Description of the invention (53) Function. The signal can be visual, auditory, tactile, electrical, chemical or biological. For example, actuators for disposable objects can release or deliver a deodorant, bismuth inhibitor, antimicrobial, antifungal, skin care composition, or P & H control agent; grab, wipe, cover, capture , Fix, seal, lose or store body waste; or trigger the release or generation of a structure or element designed to perform more than one function or to perform any other responsive function on body substances, wearers, objects, or their components. The actuator of the present invention can release potential energy to perform or activate a response function to a body substance, a wearer, an object, or a component thereof. Potential energy release can convert mechanical, electrical, chemical or thermal potential energy into mechanical, electrical, or chemical kinetic energy in response. The actuator can be triggered by an input low limit to release a bit to perform a response function, or it can continuously respond to an input as described below. For example, compressed foam has stored compressive mechanical potential and can provide mechanical kinetic energy when released. Twisted foam has stored torsional mechanical potential that provides mechanical kinetic energy (ie, rotation) when released. In addition, the stored chemical, electrical, or thermal energy can be used to release electrical, mechanical, chemical, or thermal kinetic energy. Disposable actuators may include, for example, one or more of the following: storage solutions, antifungal or antimicrobial agents, excrement modifiers, enzyme inhibitors, pH buffers, dyes, pressurized gases, compressed foam , A twisted foam, a pump, a closed system liquid transport member, an electrical sensitive, a gelatin, a pH sensitive gel, a salt concentration gel, etc. Any sufficient • Potential energy can be stored in a way that is maintained or limited as required, and suitable devices to maintain and / or limit this energy include: batteries and / or capacitors, elastic, twisted, compressive tensile materials, or The structure of the reaction reagent form and the ability to enter -56- This paper size is applicable to the Chinese National Standard (CNS) A4 specification (210 X 297 male f) ^ -------- ^ --------- (Please read the notes on the back before filling this page) 4/0 (340 Α7

仃 Materials with physical or chemical functions (such as absorbents, softeners, buffers, mother inhibitors, excrement modifiers; pressurized gases, etc.). In addition, the actuator of the present invention may include an amount of stored material having energy to perform or activate a response function to a body substance, a wearer, an object, or any component thereof. In one embodiment, for example, the actuator can be released or transported to store material for one of the response functions. In this embodiment, the actuator can be triggered by an input Z limit value to release discontinuously at a known time. Either the storage material is delivered, or the material can be continuously released or delivered. For example, the actuator may include a storage solution, a skin care composition, an antifungal or antimicrobial agent, a diarrhea modifier, an enzyme inhibitor, a pH buffer, a dye, and the like. In a particularly preferred embodiment, materials such as an inflated elastic material, a released high-pressure gas, etc. can be delivered by an actuator. Figures 2 and 2A show an actuator 90 comprising a compression elastic material 94 (e.g., foam) sealed under a vacuum at least in a portion of the pressure difference device 91. A pressure difference device used herein is any device or structure that can maintain an elastic material under a pressure state (for example, energy can be stored by providing a limited pressure on the compressed elastic material 94). A "compressed state" is defined as a condition that maintains a material with a smaller volume &lt; than when the material is unrestricted and under zero pressure. For elastic materials, compression can generally be achieved by applying pressure to the surface of the material or by any other means known in the art. For example, the pressure differential device may include a vacuum-sealed bag or a stretched material, such as an elastic or non-elastic band or band, strip, film, nonwoven, fabric, or foam to limit the elastic material. Preferably, the trigger mechanism can at least partially reduce the compression of the elastic material maintained by the pressure difference device 9 i (that is, the compressed elastic material 9 4 can be at least partially (please read the note on the back? Matters before filling out this page). -------- Order --------- Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs-57- This paper size applies to China National Standard (CNS) A4 Specification ⑽χ 297 Public Love)

V. Description of the invention (55) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs. A triggering mechanism responds to an input to equalize the pressure in the pressure difference device 91 and can at least partially swell the compressed elastic material 9 4 to any element or device, such as a sensor, an actuator , Or a combination thereof. When the compressed material is released, such as when a target bioactive analyte is detected, the compressed elastic material can swell and transport the stored material. In some embodiments, the actuation fast 90 may advantageously include a void space 96. The elastic material 94 may include any elastic material, including but not limited to: an EVA foam, such as SIF / 210PPI or Aquazone 80A from Vermillion, Inc. of Addison, PA; or from Hynes, Mass. Sendnell Products ’MC1900 EVA 2 lbs / cu. Ft .; or a HIpE foam, described on November 9, 1993 and issued to Dimarry et al. Entitled" Absorbent foam material for aqueous body fluids and containing Absorbent article of this material, US Patent No. 5,260,345; February 7, 1995 issued a certificate to Dimarry et al. "Preserving a thin absorbent foam material for wet body fluids before wetting and its manufacturing method," Patent No. 5,387,207; U.S. Patent No. 5,625,222, issued to Dimari et al. On July 22, 1997, entitled "Absorbent Foam Material for Aqueous Fluids Made from High Internal Phase Emulsions with Very High Water-Oil Ratio" ( The above-mentioned cases are incorporated herein by reference.) In some embodiments of the present invention, the pressure difference device 91 may include a bag (such as a soluble bag 92). The soluble bag 92 may have one or more different inputs ( Such as water, urine, fecal enzymes, pH, etc. ) Melts, and may have physical and / or chemical characteristics (such as thickness) designed to set the lower limit required for the bag to melt. For example, a soluble bag may contain a plastic film that is soluble in water, such as from Yili PVA film m〇n〇s〇l M7〇31 -58 of Chris Industrial Co., Ltd. in South Holland, North Holland-This paper size applies to China National Standard (CNS) A4 (210 X 297) ------ Order --------- (Please read the precautions on the back before filling out this page) Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs 476640 A7 ___ B7 V. Description of Invention (56) , M7030, M8630, M85344E6030 membranes, or HB Fuller Corporation HL 1636 * hl 1669-X in St. Paul, Minnesota. For example, the thickness of the membrane can also be modified to provide the required activation, and the membrane used, for example, can also have about 0.0000. 5 to about 0.0015 inches thick. For example, a HL 1636 film with a thickness of about 001 will be activated by a moisture content of about 0.049 grams per square inch. The actuator may additionally include an electro-sensitive gel, which is Polymeric colloidal networks, when at least partially swollen by water, Change the volume and / or geometry under the electric field. For example, when a certain part of the ionized polyacrylamide is immersed in acetone and water, about 50% of the anisotropy will be performed under a weak electric field (such as 0.5 V / cm). In addition, electrosensitive colloids can be electrically induced bending in the presence of water and a surfactant, or they can perform oscillating wave action when subjected to an oscillating electric field. It is believed that it may be in a part of the colloid (such as colloid One side of the element) initiates local shrinkage by accumulating a positive dielectric surfactant on a negatively charged colloidal polymer in an electric field. Changing the strength and / or polarity of the electric field will cause the gel to move when the length of one side is reduced (for example, the gel formed in the strip may buckle). The electro-sensitive adhesive may contain a variety of geometric shapes, such as rectangles, circles, mesh grids, etc., to provide a valve to release a material when the volume and / or geometry is changed, so that Passing, preventing a body substance from flowing through, enclosing a body substance, etc. For example, an electrically sensitive gel formed in a strip can be bent to provide usable void space when electrical activity in the external anal sphincter that occurs prior to defecation or urination is detected. In Figures 5 A and 5 B, for example, a piece of electrically sensitive gel 494 is a circuit in the figure, in which the humidity of excrement can bridge the pin 485 and make the current flow to the electrically sensitive -59- This paper standard is applicable. China National Standard (CNS) A4 Specification (210 X 297 Public Love) I— n ϋ —ϋ ϋ nn * in ϋ · ϋ n ϋ n ϋ a 1 MmmKm nnn 1 I Φ (Please read the notes on the back before filling this (Page) 476640 A7 B7 V. Description of the invention (57) The adhesive glue bends or straightens the strip. In addition, as shown in Figs. 6A, 6B, and 6C, an electrosensitive gel 59 4 forming a mesh grid type can detect that imminent urination will form a contact and / or prevent urine from flowing to the object 2 0 When a part of the valve is inflated or contracted electrically. FIG. 6A shows, for example, a circuit including a grid-like type of electrosensitive gel. Figures 6B and 6C further show micrographs of the grid of the contracted and expanded structure, respectively. One exemplary material is a weakly crosslinked PAMPs colloid (poly (aminoacrylic acid-2-methylpropionamidine) acid). This type of gel can perform various functions, such as applying or delivering a chemical excrement treating agent. Other exemplary electro-sensitive colloids are described in U.S. Patent Nos. 5,100,933 and WO9202005 issued to Tanaka on March 31, 1990, both of which are incorporated herein by reference. In addition, as the actuator of the present invention, p (R) sensitive gels or salt concentration-sensitive gels whose volume and / or geometry are changed at specific pH or salt concentration, respectively, can be used. The actuator may be configured and / or operatively connected to any part of the disposable object that enables the actuator to perform a response function to a body substance, a wearer, an object, or a component thereof. In the object 20, for example, the actuator may be located in the waist region 36, the back waist region 38, or the hip region 37 of the object 20, and may be connected to the base 22, the top layer 2 4, the bottom layer 2 6, the absorption core 2 8, The side panels 30, the foot cuffs 32, a waist feature 34, a fastening system 40, a longitudinal edge 50 or an end edge 52, etc. are integrated, adjacently arranged, or joined. The actuator may also be completely contained in an object such as the object 20, may have a portion in the object and a portion outside the object 20, or may be completely outside the object 20. Actuators or parts of actuators are operatively connected to one or more biosensors 60, one or more controllers 80, another part of an actuator or another part of an object 2〇. In addition, the actuator can be installed with (Please read the precautions on the back before filling out this page) -------- Order ------- Participate in the Consumer Property Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs to print appropriate sheets Printed paper 97 2 X 10 2 Ι-Ϊ Regulation A4 S) AN (C quasi-standard home country-60- 476640 A7 B7 printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs V. Description of the invention (58) Object 20 integrated Or may be installed by a caregiver or wearer. The object 20 may also include a controller. The "controller" herein is defined as a device that accepts an input from a biosensor state and decides whether to take one or more actions. The controller A signal may be received from the biosensor 60 and instruct the actuator to perform a response function to a body substance, a wearer, an object, or a component thereof. In addition, the actuator may directly receive the signal from the biosensor 60 and perform a response to the The wearer, body substance, object, or component thereof performs a response function. The controller may include a material that undergoes chemical or physical changes, a chemical, mechanical, or electrical device that may process information from a biosensor. Controller can be packaged Includes a signal electrical transducer that includes a multilayer Langmui_Bomgett film, where one or more layers include a biometric element. The Lanmüller-Blaget film is in contact with water It is known to instantly reorganize, resulting in areas with more layers than the original membrane and other areas with fewer layers. This reorganization allows the biometric recognition element to appear in the presence of water (for example, in a biological substance that may contain the target biological analyte) ) Is preferentially exposed to the environment. Therefore, the number of false positives can be reduced and the shelf life of the biosensor can be extended. In addition, an electric controller that receives signals such as potential from an electrochemical sensor can accept and monitor multiple The electrical signal can repeatedly trigger the actuator. The controller can be integrated with the biosensor component, integrated with the actuator component, or a separate component of the system. The controller can be configured and / or operable Connecting to any part of a disposable object enables the controller to receive a signal from the biosensor 60 and provide a signal to the actuator. In the object 20, for example, the controller can be located on the object 2 0 in the front waist area, back waist area 38 or hip area 37, and can be installed with the base and top μ -------- order --------- (Please read the note on the back first Please fill in this page again for matters) -61-476640 Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs A7 B7_______ V. Invention Description (59), Bottom 2 6, Absorbing Core 2 8, Side Panel 3 0, Foot Flanging 3 2, One waist feature 3 4, one fastening system 40, longitudinal edge 50 or end edge 52 are integrated, adjacently arranged or joined. The controller can also be completely accommodated in objects such as object 20, and can have one The share is located in the object and a part is outside the object, or it may be completely outside the object 20. The actuator or part of the actuator is operatively connected to one or more biosensors 60, one or more actuators 90, another part of the actuator or another part of the Object 2 0. For example, the controller may receive a signal from the biosensor 60 and provide a signal to the actuator, such as by a radio frequency (rf) transmission. Although different structural elements can perform the functions of the biosensor 60, the actuator and the controller, it is not necessary to use different structural elements to perform the biosensor 60, the actuator and / or the present invention. Controller functions. For example, biosensor 60 and controller functions can be performed by the same structural elements. This article "response system" is defined as an actuation that includes a biosensor 6 0 and acts on a body substance, wearer, object or component thereof when the biosensor 6 0 detects an appropriate trigger input. Actuator system. When a known input parameter is sensed, the actuator releases the stored energy or releases or transports the stored material to perform a response function. For example, when it includes a proactive sensor of a signal electrical transducer When the detector 60 detects an upcoming event, the signal electrical measuring converter provides a signal to the actuator for releasing stored energy. By detecting an input signal before the upcoming event, the signal can be triggered in the object. &lt; A response system to prepare for an event in advance, or to inform a caregiver or wearer that an event is imminent. This may constitute a preliminary "hidden" or unobstructed physical material management or processing technique but only when needed or a short time before ( (Please read the precautions on the back before filling out this page) -------- Order --------- -62- 476640 A7 B7 Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs Say (60) Objects, and / or objects that can provide a caregiver or wearer with the opportunity to prepare for the event in advance (such as applying preventive treatment to the wearer when disease-causing microorganisms or residual waste contamination is detected). Regardless of the specific input Why, the biosensor 60 in these embodiments can trigger an actuator to act on an object, a wearer, or a childbirth 'to prepare for an event or to provide a signal to the caregiver about an upcoming event. The sensor 60 includes a sensing system that can be triggered by different biosensors and / or signals-actuators, or different actuators can be triggered by different biosensors and / or signals. In addition, a Biosensors and / or signals can trigger multiple actuators. A response system can respond “continuously,” or “discontinuously,” in this article. The response system of sexually dependent output (that is, the continuously increasing input volume is required to continuously increase the output volume), or the output of the response system includes the output of passively releasing the storage material. A superabsorbent polymer placed in the absorbent core of the article, for example, provides a continuous response, where the output is quantitatively dependent on the input (i.e., when the increased liquid body mass contacts the superabsorbent polymer, the The amount of compound is to hold the liquid until the polymer capacity is used up). A chemical one = quantity reaction system is another example of a system with a continuous response to increasing output. For example, in the A + excess B + c reaction, the excess B quantity converted to c is an ideal ratio, so "Continuity is related to the amount of A available in the system. However, the" discontinuous response system "of the present invention refers to a response system having an output function that is substantially unrelated to an input amount exceeding a low threshold. For example, when one or more low thresholds of known inputs are reached, the response system can release all or a predetermined portion of the stored energy, or transport (ie, actively transport) all -63- CNS) A4 specifications_ (21〇X 297 public love) ----------- install -------- order --------- ^^ 1 (Please read first Note on the back, please fill out this page again) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 476640 V. Inventory (61) or the storage materials of the predetermined part for a specific response function. In an ideal embodiment of the present invention, the output function f (x) includes a one-step function as shown in FIG. 3A. In this embodiment, when the input amount exceeds or falls below the low limit, for an increased input The output change rate of （(d (output) / d (input)), that is, the first derivative function f of the output Θ number f (X), the slope of (X) is preferably almost zero. However, at the lower limit, the ratio d (output) / d (input) is preferably close to infinity. Therefore, in an ideal discontinuous response, the limit of the function f (xs) at time is not equal to the limit of the function £ (χ + ε) at ε +0, that is: lim f (x- ε) * lim f (x + ε) ε ε-&gt; 〇 However, the present invention understands that in a real environment, the ideal instantaneous class change at the low limit is not necessary, and in many cases it is not even possible. — In the preferred practical example, it is only necessary to make the output function have little change at the input, or almost class-like change near the input low limit. Therefore, the present invention foresees a discontinuous response system having an output function that responds in a sufficiently discontinuous manner in the transition region, so that the roll-out function has at least one minimum relative steepness in the transition region. Although not intentionally limited by the description: a specific method of a quasi-discontinuous system, in a preferred method for determining whether to perform a known output function in a sufficiently discontinuous manner as is sufficient in the present invention, the output curve at a curve The slope is compared with the relative slope of the straight line at the bottom of the transition zone: and =. For example, Fig. 4A_ shows a sample rotation function f (x), and the first order of the sample output function ^, -C »» / \ (X) Diyi &quot; order U), third order f, " (X) Contrast graph of the derivative function. The rotation function describes the result of the input (X or I) or response (R (I)) to the output. The present invention = This paper size applies the Chinese National Standard (CNS) A4 specification (210 X 297 mm pack -------- Order --------- (Please read the notes on the back before filling this page) -64 476640 V. Description of the invention (62) Transition area Defined as the area between the second derivative 値 R (Ii) and the minimum 値 R (I2) of the output function f (x). The phase ^^ is relatively the third derivative The function f, &quot; \ ,, L rule (11), (X) is equal to zero Wi. The inflection point 10 bound is the second order derivative function in the transition zone. £ ^ double 1 U) is at the point of zero, also which is:

d2R Ο dl 1 = 1 丨 The following can be used to describe the slope of the output function at the point of the money curve and the straight line between the first and last points of the crossing area:

dR (△ RT) (Please read the precautions on the back before filling out this page) l · Install k dl (△ It) Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs In this formula, the dR / dl of the inflection point is The first derivative of the output function at this point; △ τ refers to the input change of the response system between the first point L and the last point l2 of the transition zone, that is, △ &amp; 7 is the first sum of the transition zone The response change of the output function between the last points, that is, R (l2) -R (Ii); the coefficient k is used to describe the slope of the output function at the inflection point I 〇 compared to the first and last points of the transition zone The proportionality constant of the relative steepness of the slope of the line. In order for the response system to have a discontinuous output function, the proportionality constant k must be at least about -65. This paper size is applicable to the Chinese National Standard (CNS) A4 specification (210 X 297 public love). Order --------- 476640 Α7 B7 V. Invention description (63) is 2.0, preferably at least about 3.0, more preferably at least about 50, more preferably at least about 100, and most preferably at least about 100.0. In a specific embodiment, the relative steepness in the transition zone of a discontinuous response system can also be simulated by a transfer function of a control system having a series of integers n (a first-order hysteresis with an equal time constant). In the invention, the transfer function of the response system is defined as the ratio of the Laplace transform of the output (response variable) to the input (disturbance variable). For example, see Robert B. Perry and Tang Gelin's sixth edition. (McGrow Hill Corporation 1984). As shown in Figure 4B, the relative steepness of an output function can be approximated by the formula: KG (s) = K / (Ts + l) n, where KG (s) is the transfer function and κ is a ratio 値. T is the time constant of the system, and n is an integer of the first-order time lag. In this model, as the number η increases, the steepness of the output function in the transition zone increases, and the model begins to approach a discontinuous response system. Preferably, when 11 is greater than or equal to about 25, the specific discontinuous response system of the present invention can be simulated by the above formula, more preferably η is greater than or equal to about 50, and optimal η is greater than or equal to about 100. Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs as shown in FIG. 3A, a response system of the present invention may include a single low limit, where the response system may release all stored energy to perform a specific response function; or It may include a plurality of low-limit thresholds, at which each of these low-limit thresholds may release the stored energy of a predetermined material to perform one or more determined response functions. For example, in an embodiment with a single-low threshold, when the low-limit threshold is reached, the response system can release all stored energy to perform the overall response function. In this single-low-limit embodiment, in this example, The discontinuous anaesthesia system includes a system with two states such as on or off. Response system -66-? 7 printed by the Consumers ’Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs when there is a low limit of the input biological substance, such as the target biological substance, in the absorbent; Invention Note (64) A single response function can be performed on the body substance, the wearer, its objects or components, such as isolating the body substance from the user's skin, or providing an easily detectable visual signal to the wearer or caregiver. Therefore, the discontinuous response system can perform a "switching state" from one state to another when a low limit of an input occurs. In addition, as shown in Figure 3B, the response system may have Multiple low limit thresholds. When each low limit threshold is reached, the system can release a known amount of energy or deliver a known amount of material to perform a specific response function. In this embodiment, when the respective low limit values are reached, a part of the overall response function and / or ^ may be performed in response to different low limit values reached and different independent response functions may be performed. For example, a response system can monitor an excreta enzyme and deliver equal or unequal enzyme inhibitors or fluid doses when each lower limit enzyme is reached, or deliver a pH buffer at the first lower limit and perform another A response function, such as the amount of enzyme inhibitor delivered at the second lower limit. In each transition zone, the response system has substantially the same response mode as the transition zone in the single low-limit embodiment described above. In addition, a response system can monitor multiple inputs, such as one or more pathogenic bacteria and / or one or more fecal enzymes, and perform one or more response functions when the low limit of different inputs is reached, or A response function is performed only when two or more low limits of different inputs are reached. Therefore, a controller can monitor multiple different inputs and perform a different response function when the low limits of different inputs are reached. In addition, the controller can perform a logic 0 R-gate type function, so it can perform a response function when one or more low thresholds of multiple inputs are reached. The controller can also perform a logical AND-gate function, so it can perform a response function when each low limit of two or more inputs is reached. -67- This paper size _ t _ 豕 Standard (CNS) A4 specification (2ΙΓχ_297 male I ---------- installed -------- ordered -------- -(Please read the notes on the back before filling out this page) 476640 ^ ____I_ Printed by the Consumers ’Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs A7 B7 Invention Description (65) The response system may also include a“ closed loop ”or an“ open loop, The system, also known as the "closed loop" of "feedback control loop", the system includes different biosensors 60 and actuator components and performs a response function to the input. In some preferred embodiments The system can also use a parameter of a component's detection or measurement or rotation condition as at least one trigger of the response function to the input. The output condition can be a response function to the input condition when the actuator already has an opportunity1 After the input condition is reached, the response function can be performed when the output condition reaches the low limit, or only when the output condition and one or more other conditions are reached. Those who act on the input can include: act on the sensing element , Such as sensing a microorganism and Acting, or may include acting on a composition whose sensing element is an integrated component, such as sensing a fecal bacterium and acting on fecal mass or residual feces on the wearer's skin. As described above, feedback The control loop system includes at least two different components: a biosensor 60 and an actuator. The biosensor 60 detects an event: or a parameter related to the event. * The device accepts a signal And a response function is performed on the input conditions detected by the biosensor 60. The feedback control loop may further include a controller. In this case, the biosensor 60 may provide a signal to the controller, the controller The actuator can be instructed to perform a response function to the input conditions. The controller can be a separate component of the response system or can be controlled by the biosensor 60 and / or the actuator. The feedback control loop can be "non-adjustable" Change, or "modulation," "non-modulation," feedback control loop response system, the response system is used as a primary switch, where the actuator reaches the lower limit of the output conditions, the actuator Perform a response function on the input. For example, the biosensor 60 can detect the presence of a specific pathogenic microorganism or 68 paper sizes that comply with China National Standard (CNS) A4 (210 X 297 mm) ----- ----- ^ -------- ^ --------- (Please read the notes on the back before filling this page) _ ο 64 6 7 Employees of the Intellectual Property Bureau of the Ministry of Economic Affairs Cooperative prints A7 ____ ^ __ Description of the invention (66) The concentration is measured, and the actuator can notify the caregiver that there is a potential initial infection. In this example, the actuator responds to the input detected by the biosensor 600. Function. But the "" modulation "feedback control loop system includes a biosensor 600, an actuator and a controller. In the modulation feedback control loop, the output conditions are continuously or repeatedly monitored, and the controller instructs the actuator to perform a response function to the input to maintain the output conditions within the required setpoint or range, or continuously measure the target Biological analytes or concentrations. However, the "open loop" system is a system that performs a response function in response to the input without feedback, that is, the output has no effect on the sensed input into the system. The open loop system can include a response system, which has a biological function. A single device with sensor 60 and actuator functions, or may have different biosensors 60 and actuator components, where the actuators work for items other than input. Because polymers only include biological A single device that functions as a sensor 60 and an actuator is placed in a superabsorbent polymer in the absorbent core of a disposable absorbent article, for example, to provide an open-loop response. In addition, the open-loop response system may include a detector Biosensor 6 0 ′ for measuring a body substance or a component of the body substance and an actuator for performing a response function on items other than the input detected by the biosensor 60 in a continuous or discontinuous manner The invention includes a response system that provides a discontinuous or continuous response (whether open-loop or closed-loop). Other response systems were described in June 1998. 2 9th US Patent Application No. 09 / 106,424 (? &Amp; 0 Case No. 7197) entitled "Disposable Object with Discontinuous Response System"; June 29, 1998 entitled "Response System with Feedback Control Loop Included Disposable items, US patent application -69- This paper size is applicable to China National Standard (CNS) A4 (210 x 297 mm) (Please read the precautions on the back before filling this page) ▼ 丨- ------- Order --------- 476640 Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs A7 —____ B7___ V. Description of Invention (67) Please No. 09 / 107,563 (P &amp; G case number 7198); US Patent Application No. 09 / 106,225 (P &amp; G Case No. 7199), entitled "Disposable Articles Including Response System of Mechanical Actuators, June 29, 1998; Ways are incorporated herein. The diaper 20 example of the present invention may include a response system including a biosensor as shown in FIG. 1 and an actuator as shown in FIG. In this embodiment, the 'biosensor 60' may include an electrical signal transducer, and the electrical signal transducer is operatively linked to a biometric element suitable for detecting E. coli in fecal matter. When the bio-recognition element specifically detects the low limit of coliform bacteria, the signal electrical measuring converter notifies the actuator with a current. The object shown in FIG. I may include an actuator including a compressive elastic material 94, which is compressively compressed under a water-soluble film 91 (such as a pvA film), as shown in FIG. 2. Upon receiving an appropriate signal from the biosensor 60, the actuator can be turned off-on. For example, a small amount of stored water can be placed to contact and dissolve the water-soluble film 91, so the compression bubble @ 中 的 Storage mechanical energy is released. Elastic material 94 Swells and forms a fixture to provide a void volume for initial excreta. In addition, the closing of the switch can release another antimicrobial agent to control the two coliform bacteria, and / or-visually detect the dye to notify the wearer or caregiver of the presence of E. coli. In another embodiment, the response system may include an actuator, such as an abdominal wave infection or a skin irritation (such as candidiasis), which is about to occur: Event 0 Test Method Response Factor Test: The following response factor tests The response of a quantitative sensor as a response to exposure to a particular substance or composition can be measured. Wood paper scale is applicable to China National Standard (CNS) A4 specifications (plus χ 297 public love

Awl Μ -------- Order --------- (Please read the notes on the back before filling out this page) 70. 476640 Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs ---- ------ Equipment -------- Order --------- (Please read the notes on the back before filling this page) A7 B7 V. Description of the invention (68) This test is suitable The specific substance or composition includes: fecal test material in an aqueous solution having a concentration of 1 gram of fecal test material per 1 gram of physiological saline solution; test urine having i gram of fecal material per 1 gram of test urine solution Liquid; fecal material in each liquid; test urine solution; skatole solution in physiological saline with a concentration of 180 micrograms of skatole per gram of physiological saline; physiological saline solution. All measurements were performed at body temperature (37 ° C). The method included the following steps in the following order: 1) After 24 hours of exposure to physiological saline, the sensor's quantitative response was recorded. The background response was the maximum recorded response. 2) Expose the sensor to the specified substance or composition. J) The sensor is exposed to the specified substance or composition for 24 hours, and the quantitative response of the sensor is recorded. The material response is the maximum recorded response. The response factor is obtained by normalizing the material response and the background response. If the response factor is less than 1, the reciprocal of the response factor is recorded as the response factor (that is, the response can be inversely related to the input). The disclosure of all patent cases and any corresponding published foreign patent cases and the publications mentioned in the full text of this patent application are incorporated herein by reference, however, any document incorporated by reference herein does not necessarily indicate Or disclose the present invention. Although particular embodiments and / or features of the invention have been illustrated and described, those skilled in the art will recognize that various other changes and modifications may be made without departing from the spirit and scope of the invention. For example, although the form of the present invention is illustrated and described as a disposable diaper, the present invention is not limited to this embodiment. The present invention is also applicable to -71-This paper size is applicable to the Chinese National Standard (CNS) A4 specification (210 X 297 public love) ------ 476640 ------ ---____ (69) Apply directly to the wearer before applying or replacing disposable diapers, pull-through diapers, diaper inserts, tampons, tampons, etc. (eg near the anus or perineal area of the wearer) In addition, it is obvious that all combinations of these embodiments and features should be possible and can better implement the present invention. The present invention may also include the use of other independent features in the object and the other features. For example, the present invention may also include sensors and detectors, methods for preparing the sensors and detectors, and methods for using the sensors and detectors. The sensors and detection The device, whether on a specific type of object or used alone or as a diagnostic panel for other sensors, is used for a specific purpose and is not known. Therefore, the scope of the patent application is intended to cover all such changes within the scope of the present invention. And modification. ------------ install -------- --------- (Please read the back of the precautions to fill out this page) Ministry of Economic Affairs Intellectual Property Office employees consumer cooperatives printed 72-

Claims (1)

No. 89114348 Patent Application AS J Chinese Patent Application Amendment (May 90) Day 9 Application for Patent Scope 1. Disposable objects, including: a biosensor, Baigu @ ^. Τ Enclose to 〆 A biometric identification element, which is suitable for detecting a substance in the body, or on or over the skin of a wearer, without a target biological analyte, wherein the object is selected from the following: a diaper, a study pants, One = bag,-feminine hygiene device,-disposable wipes and a disposable towel. 2. 6. Printed by the Consumer Cooperative of the Central Procurement Bureau of the Ministry of Economic Affairs as a “disposable item” The analyte is rotavirus. For example, the disposable object device of the scope of patent application is a proactive sensor. For example, the disposable object device of the patent application scope is a chroma sensor. A power source for disposable objects, such as the scope of patent application item 1. A disposable object that is worn by a wearer and includes a diagnostic panel to detect body substances or on or through the skin of a user Biological analytes, the The fault panel includes: at least one first biosensor and a second biosensor, the first biosensor is adapted to detect at least one first target biological analyte, and the second biosensor Suitable for detecting at least one second target biological analyte that is different from the first target biological analyte, wherein the target is private, the biological sense tears, and the biological sense further includes a. Disposable objects, in which the biosensor paper size is applicable to Chinese National Standard (CNS) A4 specifications (210X297 mm) (Please read the precautions on the back before filling this page) 476640 ABCD Employees, Central Bureau of Standards, Ministry of Economic Affairs Printed by Consumer Cooperatives 6. The scope of the patent application includes a bio-recognition element containing a biological reactant. 8 • For the disposable item of scope 6 of the patent application, at least one of the biosensors is selected from the following : A biocatalytic biosensor and a bioaffinity biosensor. 9 · Disposable objects such as item 8 of the patent application scope, where Affinity biosensor is selected from the group consisting of: a chemosensor-based biosensor and / or an immune sensor. I 0 · At least one biometric, such as a disposable object in the scope of patent application 6 The element is selected from the following: an enzyme or sequence of enzymes; an antibody; DNA;-organelles; a membrane receptor protein; a natural or synthetic membrane 'viable or non-viable bacterial, plant, animal cells; at least A part of a nerve bundle; at least a part of a sensing organ. II. A disposable object such as the scope of application for patent No. 10, wherein the biometric recognition element is selected from Acinetobacter baumannii TOI 36 (Acinetobacter baumannii TOI36) and Bacillus sp. 1 2 · The disposable article as claimed in item 10, wherein the biometric identification device is arranged on a substrate selected from the group consisting of a polymer-based material, a hydrogel, a thin paper, a non- Weaving materials, weaving materials, and silicon semiconductors. 13. The disposable object according to item 6 of the application, wherein the biosensor is used to detect a target biological analyte selected from the following: pathogenic bacteria, colon bacteria, viruses, parasites, bacteria Sexual toxins, fungi, slugs. 1 4 · If the disposable item in the scope of patent application No. 6 is used, the paper size of the diagnostic panel is applicable to the Chinese national standard (CNS> A4 specification (210 X 297 mm) -------- Qin I — (Please read the notes on the back before filling this page) Order 476640 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs A8 B8 C8 D8 6. The scope of patent application is suitable for detecting the cause of diarrhea. 1 5 · If applying for a patent Disposable items of scope 6 wherein the first and second biosensors are each adapted to detect one or more viral causes of diarrhea to indicate to a user, caregiver or medical staff that One or more viral reasons have occurred. 1 6 · Disposable objects such as the scope of patent application No. 15 wherein the first and second biosensors are each adapted to detect at least one of the following: Viruses, Astroviruses, Calcium Viruses, Adenoviruses and Norwalk Factor Viruses. 1 7 • Disposable items such as the scope of patent application No. 6, wherein the first and second biosensors are each suitable for detection One or more bacterial causes of diarrhea The user, caregiver, or medical staff indicates that one or more bacterial causes have occurred. 1 8 • If the disposable item in the scope of patent application No. 17 is used, where the first and second biosensors are applicable. Detects at least one of the following: enteropathogenic coliform (EPEC), enterotoxic coliform (ETEC), enterohemorrhagic coliform (EHEC), enteroinvasive coliform (EIEC), and intestines Coliform bacteria (EAEC), Campylobabacter jejuni, Vibrio cholerae and Shigella-like strains include S. sonnei and Shigella · Flexneri). 1 9 · The disposable item according to item 6 of the patent application, wherein each of the first and second biosensors is adapted to detect one or more causes of diarrhea, and Instructors, caregivers, or medical personnel have indicated that _ or more reasons have occurred. 2 0 · If the disposable item in the scope of patent application No. 19, where the paper size of the _then original paper is applicable to China National Standard (CNS) A4 specifications (210X297mm) (Please read the notes on the back before filling this page) Order f 476640 A8 B8 C8 D8 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 6. Patent application scope The object identification element is suitable for detecting at least one viral cause of diarrhea, and the second biometric element is suitable for detecting at least one viral cause of diarrhea. A bacterial cause. 2 1 · The disposable item as claimed in item 6 of the patent application, wherein the first and second biosensors are each adapted to detect the cause of diarrhea—or multiple primary causes—for The user, caregiver, or medical staff indicates that one or more protozoan causes have occurred. 2 2 · Disposable items as claimed in item 6 of the scope of patent application, wherein the items are selected from the following: diapers, study pants, fecal bags, feminine hygiene ladders, pants pads, tampons, disposable wipes , And disposable towels. 23-The disposable object according to item 6 of the patent application, wherein at least one of the first or first biosensors detects a target biological analyte that exceeds only a predetermined low 1 value. 24. The disposable article according to item 6 of the patent application scope, wherein at least one of the first or first biosensors additionally includes an electrical signal transducer. 25. The disposable object according to item 24 of the patent application, wherein the signal electrical transducer is selected from the group consisting of electrochemical, optical, thermal, and acoustic signal electrical transducers. 26. If the disposable object of the patent application park No. 24 is used, only when the target biological analyte exceeds a predetermined low limit, these signal electrical converters will send a signal. 2 7 · If the disposable item in the scope of patent application No. 6 is applied, at least one of the first or second biosensors provides a signal to at least one of the following: Standard (CNS) A4 · dTx297 & ^) _ (Please read the notes on the back before filling out this page) Order f 0 — ^ I 476640 A8 B8 C8 D8 Application for Patent Scope Printed by the Central Consumers Bureau Employees Cooperatives of the Ministry of Economic Affairs : Wearer, caregiver 'actuator. A. A visual indication, such as disposable item 27 in the scope of patent application. 29. The qualitative properties of the disposables as claimed in item 27 of the patent application. 3 0. Quantitative properties of disposable objects as claimed in item 27. 31. Disposable objects such as those in the scope of patent application No. 27 shall continue for at least the entire life of the object. 3 2 · If the patentable item j in item 6 of the scope of the patent application, the item amount includes at least one of the first or second biological salt, the object, and the object sensing state. One cleaning element used. 3 3 · As for the case of the patentable item No. 6, the first and second biosensors are attached to a supporting element. 3 4 · If you can claim the item No. 33 in the scope of the patent, you can fight it. ^ It is an indisputable object, in which the support is adhered to the skin of the wearer. 35. The disposable article according to item 33 of the patent application, wherein the support member is an adhesive tape. 3 6 · Disposable objects such as the scope of patent application No. 6 The second biosensor can be detached from the object. 3 7 · Disposable article as described in item 6 of the patent application The first biosensor is adhered to the wearer's skin. 3 8 · If the disposable items in the scope of application for patent No. 6 are excreta, urine, menstruation, vaginal discharge, where the signal is where the signal is where the signal is where the signal may be ------- -, #! (Please read the notes on the back before filling out this page) Wai or Yuan Yuan Which of the first or which of the first or of the body sweat, saliva or semen quality, 1Τ f 5- π- / UUHW patent application scope A8 B8 C8 D8 Printed by the Consumers' Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs 3 9 · Rushen: Disposable article in the scope of j patent scope, where the body substance is a residue on the skin of the wearer Feces are cold-stained. 40. If the medium = disposable object in the 6th item of the patent scope, further includes an actuator to at least one of the first or second biosensors when the target biological analyte is 41 , Carry-response function. •: Disposable object in item 40 of the patent, where the response function is to provide a signal for the caregiver or wearer. 4 2. If the scope of the patent application is No. 4, the member &lt; disposable object, in which the actuator is converted to a position, which can be used to handle power, the position can be selected from one or the following items: Mechanical, electrical and chemical energy. 4; 3. The item of claim 6 further includes a receiver. % 7 b. 44. If the scope of application for patent M, &lt; discarded objects, wherein the receiving and child objects are integrated. 4 5 · If the patent application Fanyuan Item 4 3 transmitters. The shell-type object further includes a 46. For example, the μ-appearance and k * case-type object of item 6 of the patent application range, wherein the biosensory state road has at least the main factor as the response factor in the excrement. 4 7 · If you can cry crying different coffee in item 6 of the scope of application for patent * Disposable objects, in which the biosensor is violently lost the current trip f, spit T i8 per gram of physiological saline The faecal H at a concentration of OM gram skatole has a response factor of at least 5 at night. 4 8 · If you can find 4 π &amp; 丨 夂 榀 · et disposable items in the scope of the patent application, the items include the following items: diapers, learning clan, 4 excrement bags, feminine sanitary trousers , Tampons. The text smelled of raw cotton odor (please read the precautions on the back before filling in this page), 1T -6- This paper size applies Chinese National Standard (CNS) Α4 ^^ | 7ΐ〇χ297 ^^ · 476640 Ministry of Economic Affairs A8 B8 C8 D8 printed by the Central Bureau of Consumers' Cooperatives, patent application scope 49. Disposable items such as item 6 of the patent scope, where the item is an item worn by the wearer, including: A top layer; a bottom layer coupled to the top layer; and an absorbent core disposed between the top layer and the bottom layer. 5 0 · — A disposable object, including a diagnostic panel suitable for detecting common causes of diarrhea, the diagnostic panel includes: at least a first biosensor and a second biosensor, the first biological sensor The sensor is adapted to detect at least one first target biological analyte, and the second biosensor is adapted to detect at least one second target biological analyte that is different from the first target biological analyte. 51. The disposable article as claimed in claim 50, wherein the article is selected from a disposable wiper and a disposable towel. 5 2 · The disposable article as claimed in claim 50, wherein the bio-identifying element contains a biological reactant. 53. The disposable object as claimed in claim 50, wherein at least one biometric element is selected from the following: an enzyme or an enzyme sequence; an antibody 'deoxyribonucleic acid (DNA);-organelle A membrane receptor protein, a natural or synthetic membrane; viable or non-viable bacterial, plant, animal cells; at least a part of a nerve bundle; at least a part of a sensing organ. 5 4. If the disposable object of the scope of application for the item 50 of the patent, wherein the biometric identification element is selected from Baumannii Acinetobacter ΤΟΠ6 (Acinet〇bacter This paper size applies Chinese National Standard (CNS) A4 specification (210X297 public ) --------- d ------ IT ------ 0— (Please read the notes on the back before filling this page) 476640 A8 B8 C8 D8 Central Bureau of Standards, Ministry of Economic Affairs Printed by the Consumer Consumption Cooperative 6. The scope of patent applications (baumanniiT0136) and Bacillus sp. Το⑷. 55. If the disposable object in the scope of application for the item 50, the biometric identification element is arranged on a substrate selected from the following: polymer-based material, hydrogel, tissue, nonwoven Materials, and weaving materials. 56. The disposable object according to claim 50, wherein the diagnostic panel is suitable for detecting the cause of diarrhea. 57. For example, the disposable object of the patent application No. 50, wherein the first and second biosensors are each suitable for detecting one or more viral causes of diarrhea, for the user, care The person or medical staff indicates that one or more viral causes have occurred. 58. The disposable object according to item 57 of the patent application scope, wherein the first and second biosensors are each suitable for detecting at least one of the following: rotavirus, astrovirus, calcium virus, adenovirus And Norwalk factor virus. 59. The disposable object according to item 50 of the scope of patent application, wherein the first and second biosensors are each suitable for detecting one or more bacterial causes of diarrhea, so as to provide users, care The person or medical staff indicates that one or more bacterial causes have occurred. 60. If the disposable object in the scope of patent application No. 59, wherein the first and second biosensors are each suitable for detecting at least one of the following: · enteropathogenic coliform (EPEC), intestine Toxic Escherichia coli (ETEC), Enterohemorrhagic coliform (EHEC), Enteroinvasive E.coli (EIEc), and Enterococcus coliform (EAEC), Campylobacter jejuni, Cholera Vibrio and Shigella strains include Shigella Sox. The paper size is applicable to the Chinese National Standard (CNS) A4 specification (210X 297 mm) -------- if— (Please read the precautions on the back first Refill this page) Order f 476640 A8 B8 C8 D8 printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 6. Application for patents (S · sonnei) and Shigella flexneri (S · flexneri). 6 1 · If the disposable object in the scope of patent application No. 50, wherein the first and second biosensors are each suitable for detecting one or more causes of diarrhea, for the user, care The person or medical staff indicates that one or more reasons have occurred. 6 2 · The disposable article according to item 61 of the patent application scope, wherein the first biosensor is suitable for detecting at least one viral cause of diarrhea, and the second biosensor is suitable for detecting diarrhea At least one bacterial cause of the disease. 063. The disposable object as described in claim 50, wherein each of the first and second biosensors is adapted to detect one or more protozoa of diarrhea. The reason to indicate to the user, caregiver, or medical staff that one or more protozoan causes have occurred. 6 4 · —An object for detecting the occurrence of a vaginal infection, comprising: a biosensor including at least one biometric element, the biosensor is adapted to detect a target biological analyte in a substance of the body ' The biological analyte may indicate that a vaginal infection has occurred. The object is selected from the following: feminine hygiene devices, patches, disposable wipes, disposable towels, toilet paper, and liquid collection devices. 65. The item according to item 64 of the patent application scope, wherein the biological analyte indicates that bacterial vaginosis has occurred. 6 6 · If the object of the patent application No. 65 item, these biosensors detect a variety of specific types that can be said to cause bacterial vaginosis (vagin〇sis) 1, Tian Tian 'including vagina plus Denorella (Gardnerella vaginalis), Pu-9-Zhang Chilin Caiguanjia County (CNS) T ^ 721QX297 public epidemic)------------ (Please read the precautions on the back before filling (This page) Order-^ / 0040 ^ / 0040 Printed by the Consumer Affairs Cooperative of the Central Government Bureau of the Ministry of Economic Affairs Α8 Β8 C8 D8 VI. Patent Application Scope Prevotella bivia, Mycoplasma, Humanoid Mycoplasma hominis, Mobiluncus species. 67 · —An object for detecting a vaginal infection, including: a diagnostic panel suitable for detecting non-specific types of bacteria that may cause vaginosis, wherein the object is selected from the following: feminine hygiene Device, patch, disposable wiper, disposable towel, toilet paper, and liquid collection device 68. Such as the object of the patent application No. 67, wherein the diagnostic panel detects p Of amine. 69. The article according to item 64 of the patent application scope, wherein the biological analyte indicates an yeast infection. 70. The article under the scope of patent application 64, wherein the biological analyte indicates the occurrence of a sexually transmitted disease. 7 1 · The article of scope 70 in the patent application, wherein the biological analyte indicates the presence of trichomoniasis. 72. The item according to item 64 of the application, wherein the biosensor is placed on the body-facing side of a feminine hygiene device. 73. If the object of the scope of patent application No. 72, the biosensor includes at least one sensor element covered with a covering element. 74. In the case of the item No. 73 of the scope of patent application, the covering element is flexible. M. If the item in the scope of patent application No. 73, further steps include a capillary element which is adjacent to at least one sensor, so that the body material can contact the -10- House Standard (CNS). ------- ----------- (Please read the notes on the back before filling out this page) Order 476640 A8 B8 C8 D8 VI. Patent application scope This at least one sensor element. 7 6. An absorptive interlabial device, which has a body-contacting surface and includes an absorption core, and at least two detection devices are arranged on the body-contacting surface of the interlabial device, one of which detects The device can detect one substance in the urine, and at least one of these detection devices can detect one substance in the menstrual period. (Please read the notes on the back before filling out this page) Printed by the Employees' Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs -11-This paper size applies to China National Standard (CNS) A4 (210 X 297 mm)