TW467736B - Feminine sanitary disposable article having a blood detection means as sensor - Google Patents
Feminine sanitary disposable article having a blood detection means as sensor Download PDFInfo
- Publication number
- TW467736B TW467736B TW089114350A TW89114350A TW467736B TW 467736 B TW467736 B TW 467736B TW 089114350 A TW089114350 A TW 089114350A TW 89114350 A TW89114350 A TW 89114350A TW 467736 B TW467736 B TW 467736B
- Authority
- TW
- Taiwan
- Prior art keywords
- layer
- article
- blood
- absorbent
- patent application
- Prior art date
Links
Landscapes
- Absorbent Articles And Supports Therefor (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
Abstract
Description
467736 A7 B7 經濟部智慧財產局員工消費合作杜印製 五、發明說明( 發明範疇 本發明係關於婦女可棄式衛生吸收物件,且更特別關於 含有血液彳貞測裝置’其藉由含有可偵測血液之存在而顯示 生理期接近之辨識元件且可提供指示生理期接近之视覺訊 號之感應器,以預測生理期之衛生棉或褲墊。 發明背景 當今,可棄式物件,例如:尿布,成人紙尿褲,褲墊, 唇間裝置’及止血栓被廣泛地應用於婦女防護,嬰兒及幼 兒照護及失禁成人之照護中,用以容納,分離並處理人體 之排泄物《由於其方便性及可靠性,此等物件已逐漸取代 可重覆使用,可清洗之衣物,成爲此等應用中之較佳用 具。此可棄式物件藉由將人體排泄物吸收或容纳於該物件 上以處理排泄物。一些可棄式物件含有化學反應裝置以偵 測及辨識使用者排泄物中之不同物質。然而,其中並未有 專用於偵測或摘測生理期相關性排出物即將出現並對穿用 者或受照護者發出生理期發生之訊號者。 本發明之目標乃是達到婦女消費者需要得到關於其生理 期期望時間之更多訊息,而目前尚未達到之需求。更廣泛 地説,頃已確立婦女想要知道更多有關及偵測其身體狀況. 與其生理期周期狀態之相關性並作爲任何型式之相關病變 進展之預警^ 因此’根據本地之專利法本發明可包括兩個隸屬不同專 利申請範園之向度。一個向度係爲本發明於醫療診斷目的 中之研發,而另一向度爲純非醫療利益以提供與生理期接 -4- 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) :-----------i,.!、裝--------訂---^-------v t請先閲讀背面之注意事項存填寫本頁) A7 B7 467736 五、發明說明(2) 近相關之早期訊息使得消費者可採取相關措施,例如:開 始使用衛生棉或止金检。 許多揭示用於與婦女生理期周期及陰道/尿道相關訊東 有關之一般診斷目的上。然而’下列參考資料中,並無對 本發明提供特別示敎者。467736 A7 B7 Consumption Cooperation by Employees of the Intellectual Property Bureau of the Ministry of Economic Affairs. Du V. Description of the Invention (Scope of the Invention The present invention is about women's disposable sanitary absorbent articles, and more specifically about containing blood test devices. A sensor for detecting the presence of blood and displaying a physiological period approaching, and a sensor that can provide a visual signal indicating the physiological period approaching, to predict the physiological period of a tampon or pant. BACKGROUND OF THE INVENTION Today, disposable objects, such as diapers, Adult diapers, pant pads, interlabial devices' and tampons are widely used in women's protection, infant and toddler care, and incontinence adult care to contain, separate and dispose of human excrement "due to its convenience and reliability These items have gradually replaced reusable and washable clothing and have become a better tool in these applications. This disposable object treats fecal matter by absorbing or containing it on the object Some disposable objects contain chemical reaction devices to detect and identify different substances in user excretion. However, none of them There are those who are dedicated to detect or extract the physiological period-related discharge is about to appear and send a signal to the wearer or caretaker that the physiological period occurs. The object of the present invention is to meet the needs of women consumers to obtain their physiological period expectations More information about time, but currently unmet needs. More broadly, it has been established that women want to know more about and detect their physical condition. Correlation with their physiological cycle status as any type of related lesion Early warning of progress ^ Therefore, according to the local patent law, the present invention may include two dimensions belonging to different patent application parks. One dimension is the research and development of the invention for medical diagnostic purposes, and the other dimension is purely non-medical Benefits to provide connection with the physiological period -4- This paper size applies the Chinese National Standard (CNS) A4 specification (210 X 297 mm): ----------- i,.!, Equipment --- ----- Order --- ^ ------- vt, please read the notes on the back and fill in this page) A7 B7 467736 V. Description of the invention (2) The related early information allows consumers to take Relevant measures, such as: the use of sanitary pads or stop money . Many disclosures are used for general diagnostic purposes related to women's physiological cycles and vaginal / urethral-related information. However, 'the following references do not provide a specific indication of the present invention.
Scii0nfeld等人公開於1993年6月8日之US 5,217,444中揭 示吸收墊,例如含有pH指示劑可藉由顏色變化指示液體 之酸性或驗性之止血检〇該指不劑可被整片所吸收之陰道 分泌物潤濕。此即可視pH値作爲婦女陰道健康狀況之指 示。Sciionfeld et al., Disclosed in US 5,217,444, June 8, 1993, disclose absorbent pads, such as a hemostatic test containing a pH indicator that can indicate the acidity of a liquid or a blood test by a change in color. Wet vaginal discharge. This can be regarded as an indicator of vaginal health of women.
Everhart等人公開於1995年1 1月2 1日之US 5,468,236中 揭示一種合併化學反應物質之可棄式吸收產品,其可針對 吸收液如:陰道排出物中之化學成份提供視覺指示。該專 利並不限於其特殊目的但其例示一種可棄式尿布,其中葡 萄糖指示性膠體可使用於表.層或吸收核心。在第二個實例 中,所偵測之化學成份爲硝酸鹽,其作爲尿道受革蘭式陰 性菌感染♦指示劑。特別地,Everhart提供一’種經由催化 順序後終點安定之反應以使得進一步之液體吸收不會改變 指示效果β _Everhart et al., Disclosed in US 5,468,236, November 21, 1995, discloses a disposable absorbent product incorporating chemically reactive substances, which can provide a visual indication of chemical components in an absorbent fluid such as vaginal discharge. The patent is not limited to its special purpose but it exemplifies a disposable diaper in which a glucose-indicating colloid can be used in a surface layer or an absorbent core. In the second example, the chemical component detected was nitrate, which serves as an indicator of urethra infection with Gram-negative bacteria. In particular, Everhart provides a ’end-point stable reaction via a catalytic sequence so that further liquid absorption does not change. Indication effect β _
Morz等人公開於1980年1 1月4日之US 4,231,370中揭示 具有存在於固體附著基質中之p Η敏感性濕性指示劑之可 棄式尿布。Morz et al., Disclosed in US 4,231,370, November 4, 1980, discloses a disposable diaper having a p (R) sensitive moisture indicator present in a solid attachment matrix.
Richards 等人公開於 1998 年 1 0 月 20 ΕΙ 之US 5,823,953 係 關於一種用於酵母或非酵母相關性陰道感染之自我診斷系 -5- 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) i靖先閲讀背面之汷意事項再填寫本頁} ,m 1 I n ϋ n n I n 言 5. 經濟部智慧財產局員工消費合作社印製 467736Richards et al., US 5,823,953, published on October 20, 1998, is a self-diagnosing system for yeast or non-yeast-associated vaginal infections. -5- This paper is in accordance with Chinese National Standard (CNS) A4 (210 X 297 mm) i Jing first read the intention on the back and then fill out this page}, m 1 I n ϋ nn I n remarks 5. Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 467736
五、發明說明(3 ) (請先閱讀背面之注意事項再填寫本頁) -111 I ! I 訂----... — I.丨· _ L. 統其呈生理期墊或褲墊之型式,具有可剝離,可呈色之 Ρ Η指示片於表層上。該ρ Η指示劑可識別吸收液之p H是 否高於或低於4.5之閥值且可不需内科醫師診斷決定有關 酵母或非酵母性陰道感染之治療。V. Description of the invention (3) (Please read the precautions on the back before filling out this page) -111 I! I Order ----... — I. 丨 · _ L. It is a physiological pad or pant pad This type has a peelable and colorable PZ indicator sheet on the surface layer. The ρ Η indicator can identify whether the pH of the absorbent is higher than or lower than the threshold of 4.5 and can be determined without the need for a physician's diagnosis to treat yeast or non-yeast vaginal infections.
Buck等人公開於1997年1 1月27日之W0 97/43955中揭示 一種收集生理期液中之陰道液及剝落之陰道細胞之家庭珍 斷用套組。該液體或細胞被收集於吸收性唇間墊或置於孔 狀外殼中並放置於陰道内部以收集液體之墊片中e之後可 使用該液體於所欲之診斷目的中。Buck et al., Disclosed in WO 97/43955, November 27, 1997, discloses a family treasure set for collecting vaginal fluid and exfoliated vaginal cells in physiological fluids. The liquid or cells are collected in an absorbent interlabial pad or placed in a porous shell and placed in a pad inside the vagina to collect the liquid. The liquid can then be used for the desired diagnostic purpose.
Echeveria公開於1996年4月3日之EP 704 195中揭示一種 生理期偵測器,其包括含有化學成份之衛生棉或褲墊,其 隨液.體之吸收可提供一種冷反應作為生理期開始之指示劑 以使穿用者有足夠的時間以全尺寸及全容量之衛生棉或止 血栓來取代指示性吸收物件。 經濟部智慧財產局員工消費合作社印製 當然’許多諸如此般之指示劑已被知曉且通常無關於所 欲分析之液體來源。例如’ Ismael等人公開於199〇年9月 12日之EP 3 86 562中揭示一種具有顏色指示效果之乾酵素 試驗组合物。Buck等人公開於1990年6月1 4曰之WO 90/06511中揭示一種可測定液體樣品中分析物之存在的安 定化指示劑。同樣地,Bouse等人公開於1989年1 1月3 0日 之WO 89/11643中揭示一種設計用以增廣可分析之分析物 濃度範圍之指示劍組合物。Echeveria published in EP 704 195 of April 3, 1996 discloses a physiological period detector, which includes a chemical-containing sanitary napkin or panty pad which absorbs fluid and provides a cold response as the beginning of the physiological period. The indicator allows the wearer sufficient time to replace the indicator absorbent article with a full-size and full-volume sanitary napkin or tampon. Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economics Of course ‘many such indicators are already known and usually not relevant to the source of the liquid to be analyzed. For example, 'Ismael et al., Disclosed in EP 3 86 562, September 12, 1990, discloses a dry enzyme test composition having a color indicating effect. Buck et al., WO 90/06511, published June 14, 1990, discloses a stabilizing indicator that can determine the presence of an analyte in a liquid sample. Similarly, Bouse et al., Disclosed in WO 89/11643, November 30, 1989, discloses an indicator sword composition designed to broaden the range of analyte concentration that can be analyzed.
Oksman等人公開於1984年1 1月7日之EP 124 215及EP 124 214兩者係關於潛血特別是用於糞中潛血分析之塗抹 -6- 本紙張尺度適用中國國家標準(CNS>A4規格(210 X 297公釐) --—1 ______ j----- 經濟部智慧財產局員工消費合作社印製 467736 A7 B7 五、發明說明(4〉 指示劑。同樣地,Wells公開於1983年1 1月9日之EP 93 5 95係關於一種用於血紅素特別是糞中潛血之單一步騾 測定之乾性診斷器。Oksman et al. Published on January 7, 1984, EP 124 215 and EP 124 214 are both smears for occult blood, especially for analysis of occult blood in feces. -6- This paper standard applies Chinese national standard (CNS > A4 specification) (210 X 297 mm) --- 1 ______ j ----- Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 467736 A7 B7 V. Description of the invention (4> Indicator. Similarly, Wells was published in 1983 1 EP 93 5 95 on January 9 is a dry diagnostic device for single step radon determination of heme, especially occult blood in feces.
Rotite公開於1984年7月25日之EP 113 896係關於一種化 學試驗片,其中之塑膠膜片上有試驗藥劑可作定量分析之 用。本發明例示血液及葡萄糖試驗。Rotite EP 113 896, published on July 25, 1984, is a chemical test piece in which a test agent is placed on a plastic diaphragm for quantitative analysis. The invention exemplifies blood and glucose tests.
Roy 公開於 1984 年 3 月 7 Θ 之 EP 101 980 及 EP 101 979 係 關於用於快速臨床分析及診斷之法氫酶測定 '後者中提到 載體可為含有纖維素纖維之止血栓。 此外’許多醫學性論文係關於婦女陰道及泌尿器官之病 理狀況,包括其偵測及治癒之方法均已公開。 .發_明之概要說明 本發明係關於婦女使用之衛生吸收物件,其可針對滞留 .於該物件上含有人類肉眼無法以正常目視檢查法分辨之血 量之陰道排出物提供可目測之血液偵測。該物件通常為層 狀構造’每一層具有朝穿用者表面及朝衣物表面。一般而 言’孩物件於朝穿用者表面上含有一液體可滲透性頂層, 於朝衣物表面上含有—液體阻隔底層,於頂層及底層間夹 入一層吸收核心。根據本發明,該物件較佳為衛生棉或.褲 塾’特別是厚度小於3毫米之薄褲整且更佳為適合穿用者 於狹窄底褲.内且一般為三角形之褲墊(亦可為狹長型或窄 整狀)。 根據本發明,該物件含有一種血液偵測裝置,.其含有至 少含選自於過氧化物或過酸或其結合物之第一種成份,及 本紙張尺度適財國國家標準(CNS)乂4規格(21〇 x 297公楚) (請先¾.讀背面之注意事項再填寫本頁) -—/. 裝-------"·訂-------I T . 467736 A7 B7 五、發明說明(5 ) 經濟部智慧財產局員工消費合作社印製 選自於癒創膠或四甲基聯苯胺或其組合之第二種成份之化 學組合物。該組合物較佳爲進一步含有表面活性之物質例 如:界面活性劑或較佳爲聚乙二醇。 於一根據本發明之較佳具體實例中,第一種成份爲epta-缺酿亞胺基-過氧己酸且第二種成份爲療創膠。第一及第 一種成份較佳爲分開於該吸收物件中更佳者,一種成份存 在於一層中之朝衣物表面上且另一種成份存在於第二層之 朝衣物表面上或一種成份存在一層之朝穿用者表面上,較 佳者’核心及另一成份存在於同一層之朝衣物表面上。 當將组合物塗佈於物件上時,其較佳乃呈液體型式 佳者爲溶於組合物塗佈後可蒸發之有機載體中之溶液 利用包覆或更佳爲喷霧進行塗佈。 本發明之範圍亦包括於血液偵測器中增添額外之生理期 相關性偵測器,例如,適於偵測所吸收之陰道排出物内可 作爲生理期接近之指示的生理變化之額外生物化學或電子 化學或化學偵測裝置且較佳爲可對此物件之使用者提供另 一種,更強化或經修飾之視覺訊號者》較佳者,此等額外 之债測裝置含有pH指示劑或黃體素或動情素指示劑或其 結合物者。 本發明之詳細説明 定義 本文中所使用之,'吸收物件,,一辭係指吸收並容納人體 出物之裝置,且更特別者,係指放置於緊臨或靠近穿 之身體以吸收或容納由人體排出之各種排出物者 可。本文 更 可 排 者 中 (請先閱讀背面之注意事項再填窝本頁)Roy's EP 101 980 and EP 101 979, published on March 7th, 1984, are about hydrogenase assays for rapid clinical analysis and diagnosis. The latter mentions that the carrier may be a thrombus containing cellulose fibers. In addition, many medical papers have been published on the pathological conditions of women's vagina and urinary organs, including methods for their detection and cure. Fa_ming Brief Description The present invention is a hygienic absorbent article for women, which can be targeted for retention. Vaginal discharge containing human blood that cannot be distinguished by normal visual inspection on the article provides visual blood detection. . The article is usually a layered structure 'with each layer having a wearer-facing surface and a garment-facing surface. Generally speaking, a child article contains a liquid-permeable top layer on the wearer-facing surface, a liquid-blocking bottom layer on the garment-facing surface, and an absorbent core sandwiched between the top layer and the bottom layer. According to the invention, the article is preferably a sanitary napkin or a pant, especially thin pants with a thickness of less than 3 millimeters, and more preferably suitable for wearers in narrow bottoms. Generally, it is a triangular panty (also It is narrow or narrow). According to the present invention, the article contains a blood detection device, which contains at least a first component selected from the group consisting of peroxides or peracids, or a combination thereof, and the national standard (CNS) of this paper for fiscal standards. 4 specifications (21〇x 297). (Please read the precautions on the back before filling out this page) ----- /. Installation ------- " · Order ------- IT. 467736 A7 B7 V. Description of the Invention (5) The consumer cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs printed a chemical composition of the second component selected from guaiac or tetramethylbenzidine or a combination thereof. The composition preferably contains a surface-active substance such as a surfactant or preferably polyethylene glycol. In a preferred embodiment according to the present invention, the first component is epta-deficient imino-peroxyhexanoic acid and the second component is a therapeutic wound gel. The first and first ingredients are preferably separated from the absorbent article, one ingredient is present on the garment facing surface in one layer and the other ingredient is present on the garment facing surface in the second layer or one layer is present on one component On the wearer-facing surface, the preferred'core and another component are present on the garment-facing surface of the same layer. When the composition is applied to an object, it is preferably in the form of a liquid. The solution is preferably a solution dissolved in an organic vehicle that can be evaporated after the composition is applied, and coated by coating or more preferably by spraying. The scope of the present invention also includes the addition of an additional physiological phase correlation detector to the blood detector, for example, additional biochemistry suitable for detecting physiological changes in the absorbed vaginal discharge that can be used as an indicator of physiological phase proximity. Or an electronic chemical or chemical detection device and preferably a user who can provide another, more enhanced or modified visual signal for this object ", preferably, these additional debt measuring devices contain a pH indicator or corpus luteum Or estrogen indicator or a combination thereof. The detailed description of the present invention defines the term "absorbent article" as used herein to mean a device that absorbs and contains the body's output, and more particularly, it refers to a body placed close to or close to the body for absorption or containment. Various discharges from the human body are acceptable. This article can be ranked among the more (please read the precautions on the back before filling in this page)
---I ! — 訂--- I 摩 6 -8 - 467 736 A7 五、發明說明(6) 所使用之可棄式—辭係說明—般而言,作為吸收物件 時不欲再清洗或再貯存或再使用之吸收物件(即:其經 使用一次後便丟棄)。本文中所使用之"接合的"一辭包含 藉由將元件且接站在另一元件上而使一元件直接固定於 另一兀件上之結構,及將一元件贴在中間體(一種或多種) 上再貼於另—元件上而使一元件間接固定於另一元件上 之結構》"單一 ’’吸收物件係指由個別組件組合成一集合 體^吸收物件,以使其不需個別之操作性組件,例如個 別疋支持體及墊片β本發明之吸收物件之較佳具體實例係 為單可棄式衛生棉或褲塾或唇間吸收物件,然而可棄式 失禁褲,失禁内褲’吸收插入物,及止血栓等若使用於生 理期則之時期内亦可由本發明得到利益。 根據本發明之吸收物件一般係由三種主要元件所構成: 頂層,於使用該物件時朝向使用者且為液體可透性以使得 液體可滲入物件;底層,具有液體阻隔性以使得所吸收之 液體無法漏出物件外,此底層一般位於物件之朝衣物表 面’及吸收核心,其夹於頂層及底層之間且提供物件之吸 收容量以吸取並保留透過頂層流入物件中之液體。 許多吸收物件及構造體為此技藝中已知廣者且在過去已 被充分詳盡說明。所有此等材料均可用於本發明中,倘若 其不受所選擇之生理期預測感應器之干擾。下文中僅述及 彼等實例’其使用於根據本發明之較佳吸收物件中特別有 利者。彼等熟習此技藝者可隨時找出亦可使用且特別是可 適用於根據本發明之關於生理期預測吸收物件中之取代性 (請先閱讀背面之注意事項再填寫本頁)--- I! — Order --- I Mo 6 -8-467 736 A7 V. Description of the invention (6) Disposable type used-Word description-Generally speaking, as an absorbent article, do not want to clean or Absorbent articles that are stored or reused (ie, they are discarded after one use). The term " joined " as used herein includes a structure in which one element is directly fixed to another element by attaching the element to another element, and attaching the element to an intermediate (a kind of Or more) and then affixed to another—a structure in which one component is indirectly fixed to another component "" Single " absorptive article refers to the assembly of individual components into a collection ^ absorptive article so that it does not need Individual operational components, such as individual diarrhea supports and pads. The preferred specific examples of absorbent articles of the present invention are single-disposable sanitary napkins or pants or interlabial absorbent articles, but disposable incontinence pants, incontinence Underwear 'absorbent inserts, and tampons, etc. can also benefit from the present invention if they are used in the physiological period. An absorbent article according to the present invention is generally composed of three main elements: a top layer, which is liquid-permeable to the user when the article is in use, so that liquid can penetrate the article; a bottom layer, which has liquid-barrier properties so that the absorbed liquid Can not leak out of the object, this bottom layer is generally located on the garment-facing surface of the object and the absorption core, which is sandwiched between the top layer and the bottom layer and provides the absorption capacity of the object to absorb and retain the liquid flowing into the object through the top layer. Many absorbent articles and structures are well known in the art and have been fully explained in the past. All of these materials can be used in the present invention provided that they are not disturbed by the selected physiological period prediction sensor. In the following, only those examples are mentioned which are particularly advantageous for use in the preferred absorbent article according to the present invention. Those skilled in this art can find substitutions at any time that can also be used, and especially applicable to the physiological period prediction absorbent article according to the present invention (please read the precautions on the back before filling this page)
\/ -J,/ 裝----— 11^,-------I I 經濟部智慧財產局員Η消費合作社印製 -9 - 67736 A7\ / -J, / 装 ----— 11 ^, ------- I I Printed by a member of the Intellectual Property Bureau of the Ministry of Economic Affairs and printed by a consumer cooperative -9-67736 A7
五、發明說明(7) 材料。 經濟部智慧財產局員工消費合作社印製 項層 -般而言,頂層爲柔軟,可變形的,觸感柔順且對穿用 者又皮膚無刺激性者。頂層較佳亦具有彈性以使其可承受 單或雙向之拉力。本文中所使用之,, 、 广人Τ /7Γ仗斤』< 可變形的"一辭係指 柔軟JL隨時可順應人體之一般形狀及輪廓之材料。 頂層可由非編織性或編織性材質或已藉由穿孔處理而成 爲液體可穿透性之薄膜製造而得。頂層亦可爲複合材質或 由-層以上所構成’例如,其可具有第.二頂層.或導流層。 此等薄膜及非編織品或織品可由例如聚合物如聚乙烯或 聚丙歸组合物製造而得。通常此等聚合物已被充滿染色物 質例如:二氧化鈦以提供其潔白不透明度。此等頂層亦可 不含染色物質以提供透明膜或具有高透光性之非織品,若 不含顏色填充劑,例如二氧化鈦時,並不會造成任何實質 上之材料變化。此等頂層對内含於物件中,藉由顏色變化 之發生與否提供目視檢查之生理期預測劑特別有益處。由 於製造頂層之聚合性材質中缺乏不透明顏色填充劑(或降 至1 5 %以下,即約正常用量之一半),其可額外提供良好 之檢查特性(此外亦可降低成本及環境之負擔)。頃亦可使 用非不透明’淡色之顏色填充劑以使其具有顏色但仍透明 或部份透明此等淡色可用以隱藏根據本發明之有色指示 劍之起始或終點顏色,且其較佳爲淺黃或藍色。 頂層可爲透明或僅呈部份透明。然而,對根據本發明之 大部分具體實例而倘若頂層爲可目視檢查出顏色變化 -10 - 本紙張尺度適用中國圉家標準(CNS)A4規格(210 X 297公釐) (請先閲婧背面之注意事項再填寫本頁) βτ ο 467736 A7 ______B7 五、發明說明(8 ) 之半透明狀即已足夠。 底層 (請先閲讀背面之注意事項再填寫本頁) 一般而言,底層爲柔軟,可變形的且.觸感柔順者。底層 可避免吸收並保留於吸收核心中之滲出物將與吸.收物件接 觸之衣物’例如底褲弄濕》較佳者.,底層爲液體(例如:生 理期,汗液及/或尿液)無法透過者。其可由薄塑殿膜製造 而得,雖然其他可變形之液體不透性材質亦可使用。本文 中所使用之"可變形的"一辭係指柔敕且隨時可順應人體 之一般形狀及輪廓之材料β底層較佳亦可具有.彈性以,使其· 可承受單或雙向之拉力。 底層可包含編織性或非編織性材料,聚合膜,例如.聚 乙、烯或聚丙烯之熱塑膜,或複合材料,例如··膜披覆之非 編織性材料或纖維披覆膜。常用之吸收物件含有厚度約 0.012¾米至約0.051.¾米之聚.乙綿·乙綿膜底層,其可利用 内邵填充劑及隨後之機械性伸張而成爲無滲透性或微孔 狀。 經濟部智慧財產局員工消費合作社印製 底層較佳爲具透氣性,即:可使水蒸氣穿透.,或更佳爲 空氣可穿透,但卻不犧牲其可防止吸收液滲漏之主要目 的。底層亦可包含不止一層透氣層,其可以至少2或3層 不同或相同材質取代單一透氣層a特別是兩層透氣層爲較 佳之透氣性底層構造,其中例如:其中朝穿用者表面的一 層爲具有二度空間結構之格狀多孔狀膜且例如:另一層朝 衣物層係由熔吹及旋轉結合纖維複合而成之非織品。與頂 層叙,底層可由可容許簡易地檢查物件内部之债測器之 -11 -V. Description of the invention (7) Materials. Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs-In general, the top layer is soft, deformable, soft to the touch, and non-irritating to the skin of the wearer. The top layer is also preferably flexible so that it can withstand unidirectional or bidirectional tension. As used in this article, the term "Guangren T / 7Γ" refers to a material that is flexible and can conform to the general shape and contours of the human body at any time. The top layer can be made of a non-woven or woven material or a film that has been perforated to become liquid permeable. The top layer may also be a composite material or be composed of-or more layers', for example, it may have a second top layer or a diversion layer. These films and nonwovens or fabrics can be made from, for example, polymers such as polyethylene or polypropylene. Usually these polymers have been filled with dyed substances such as titanium dioxide to provide their white opacity. These top layers may also be free of dyeing materials to provide transparent films or non-woven fabrics with high light transmission properties. Without color fillers, such as titanium dioxide, no substantial material changes are caused. These top layer pairs are included in the object and are particularly useful as physiological period predictors that provide visual inspection by the presence or absence of color changes. Due to the lack of opaque color filler in the polymerizable material used to manufacture the top layer (or reduced to 15% or less, which is about one-half the normal amount), it can additionally provide good inspection characteristics (in addition, it can reduce the cost and environmental burden). It is also possible to use non-opaque 'light-colored color fillers to give it a color but still transparent or partially transparent. These light colors can be used to hide the start or end color of the colored indicator sword according to the present invention, and it is preferably light Yellow or blue. The top layer can be transparent or only partially transparent. However, according to most specific examples of the present invention, if the top layer is visually detectable, the color change is -10-This paper size applies the Chinese Standard (CNS) A4 (210 X 297 mm) (please read the back of Jing first) Please note this page before filling in this page) βτ ο 467736 A7 ______B7 V. The semi-transparent shape of the invention description (8) is sufficient. Bottom layer (Please read the notes on the back before filling out this page) Generally speaking, the bottom layer is soft, deformable and soft to the touch. The bottom layer can avoid absorption and the exudate retained in the absorbent core will be in contact with the absorbent. The clothing in contact with the receiving object 'such as wet bottoms' is preferred. The bottom layer is liquid (eg, physiological period, sweat and / or urine) Impossible. It can be made from thin plastic film, although other deformable liquid-impermeable materials can also be used. The term " deformable " as used herein refers to materials that are flexible and ready to conform to the general shape and contour of the human body at any time. Β The bottom layer is preferably also able to have elasticity so that it can withstand unidirectional or bidirectional pull. The bottom layer may comprise a woven or non-woven material, a polymeric film, such as a thermoplastic film of polyethylene, olefin, or polypropylene, or a composite material, such as a film-coated non-woven material or a fiber-coated film. Commonly used absorbent articles contain a polymer with a thickness of about 0.012 ¾ m to about 0.051. ¾ m. Ethyl cotton · Ethyl cotton film bottom layer, which can be made non-permeable or microporous with the use of internal fillers and subsequent mechanical stretching. The printed layer of the employee's consumer cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs is preferably breathable, that is, it can penetrate water vapor, or better, it can be penetrated by air, but it does not sacrifice its main reason to prevent leakage of absorbent fluid. purpose. The bottom layer may also include more than one breathable layer, which may replace at least 2 or 3 layers of different or the same material for a single breathable layer a, especially two breathable layers are a better breathable bottom structure, for example: one layer facing the wearer's surface It is a grid-like porous film with a two-dimensional spatial structure and, for example, another layer facing the clothing layer is a non-woven fabric composed of melt-blown and rotating bonded fibers. Unlike the top layer, the bottom layer can be used by a debt detector that allows easy inspection of the inside of the object.
本紙張尺纟 t國國家標準(CNS)A4規格(210 X 4 6 7 73 6 A7 _B7__五、發明說明(9) 透明或半透明材質製造而得。同樣地,其亦可使用淡色填 充劑,較佳爲淡黃或藍色。 吸收核心 •常用之吸收核心可爲單一體或包含數層。其可包括下列 組成(a):視需要之第一流體分散層;(b)視需要之第二流 體分散層;(c )流體貯存層;(d )視需要位於貯存層下方 之纖維層;及(e)其他視需要之组成。 a. 第一流體分散層 根據本發明於吸收核心中之一種视需要存在乏組成爲第 一流體分散層。此第一流體分散層通常位於頂層下方(若 存在)且流體随後流入其中。第一流體分散層將所得之體 液分散至貯存層中。透過第一流體分散層之流體傳送主要 爲厚度方向,但亦可延者長形褲墊之縱向或橫向分散。 b. 視需要之第二流體分散層. 根據本發明亦視需要存在者爲第二流體分散層。此第二 流體分散層通常位於第一流體分散層下方且流體隨後流入 其中。第二流體分散層之目的係随時吸收來自·於第一流體 分散層之體液並在其轉移至下方貯存層之前,將之延著長 形褲墊之縱向或横向分散。此有助於下方貯存層之流體容. 量之完全利用。 c. 流醴貯存'層 位於流體可滲入.,且通常於第一或第二分散層之下方者係 爲流體貯存層。其較佳包含,但不必需姜超吸收膠體材質,, 通常稱爲:"水凝膠"(hydrogels ),”超吸收體”"水膠體" * 12 - 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) (請先閲讀背面之注意事項再填寫本頁) n n tn n Ha 訂-------I. 467736 Α7 Β7 五、發明說明(10) * (hydrocoUoid)材質。吸收膠體材質爲彼等接觸液態流 體,特別是體液時,可吸收此等流體並形成水凝膠之材 質。此等吸收膠體材質通常可吸收大量之體液,且進—步 可於中等壓力下保留此等被吸收之流體。於先前技藝中, 此吸收膠體材質通常呈分散,非纖維顆粒之顆粒型式。然 而,根據本發明,此等超吸收膠體材質亦可呈非顆粒型 式,較佳爲呈纖維狀。倘若不提供吸收膠體材質,則貯存 層通常需具有下文所揭示作爲載體材質之材質。 於流體貯存層中,此等吸收膠體材質可均一或非均一性 分散於適當之纖維狀基質,亦稱爲载體中。適當之載體包 括:纖維素纖維,呈絨毛或薄紙狀,例如通常利用於吸收 核u中者。亦可俾用修飾性纖維素 '纖維,例如:硬化纖 維素纖維或黏膠纖維。合成纖維亦可使用且包括彼等由醋 酸纖維素,聚氟化乙晞,聚氣化亞乙烯,丙晞塑膠(例如: 歐龍(Orion)),聚乙烯乙酯,不溶性聚乙晞醇,聚乙浠, 聚丙烯,聚醯胺(例如:尼龍),聚酯類,雙成份纖維,三 成份纖維,其混合物及類似者所製成者。較佳之合成及人 造纖維爲細度约每絲3丹尼至每絲約2 5丹尼者,更佳者爲 每絲为5丹尼至每絲約丨6丹尼者。載體纖維可爲刷毛,旋 轉、..m,熔吹,濕式抽絲,空氣抽絲之基質或此等製造方 法之結合或此等基質之結合。 亦較佳者,孩纖維表面爲親水性或經處理成親水性。貯 .存層亦可包括填充材料,例如:珍珠岩,矽藻土,蛀石 等其可減少復濕問通。貯存層進一步可含有結合劑,包 -13-The paper size is the national standard (CNS) A4 specification (210 X 4 6 7 73 6 A7 _B7__ V. Description of the invention (9) Manufactured from transparent or translucent materials. Similarly, it can also use light-colored fillers , Preferably light yellow or blue. Absorptive cores • Commonly used absorbent cores can be monolithic or contain several layers. It can include the following components (a): a first fluid dispersion layer as needed; (b) as required A second fluid dispersion layer; (c) a fluid storage layer; (d) a fiber layer underneath the storage layer as needed; and (e) other composition as needed. A. The first fluid dispersion layer in the absorbent core according to the present invention One is a first fluid dispersion layer, if necessary. This first fluid dispersion layer is usually located below the top layer (if present) and the fluid subsequently flows into it. The first fluid dispersion layer disperses the resulting body fluid into the storage layer. The fluid transmission through the first fluid dispersion layer is mainly in the thickness direction, but it can also be longitudinally or laterally dispersed in a long panty liner. B. A second fluid dispersion layer as required. Two fluid dispersion layer This second fluid dispersion layer is usually located below the first fluid dispersion layer and the fluid subsequently flows into it. The purpose of the second fluid dispersion layer is to absorb body fluids from the first fluid dispersion layer at any time and before it is transferred to the lower storage layer And spread it longitudinally or laterally along the long panty pad. This helps to fully utilize the fluid capacity of the storage layer below. C. The fluid storage layer is located where the fluid can penetrate. The lower part of the second dispersion layer is a fluid storage layer. It preferably contains, but does not require ginger superabsorbent colloid material, and is usually called: "hydrogels", "superabsorbers". Hydrocolloid " * 12-This paper size applies to Chinese National Standard (CNS) A4 (210 X 297 mm) (Please read the precautions on the back before filling this page) nn tn n Ha Order ------ -I. 467736 Α7 Β7 V. Description of the invention (10) * (hydrocoUoid) material. Absorbing colloid materials are materials that can absorb these fluids and form hydrogels when they come into contact with liquid fluids, especially body fluids. These absorptions Colloidal material usually absorbs large Body fluids, and can further retain such absorbed fluids under moderate pressure. In the prior art, this absorbent colloidal material was usually in the form of dispersed, non-fibrous particles. However, according to the present invention, these superabsorbents The colloid material can also be non-granular, preferably fibrous. If no absorbent colloid material is provided, the storage layer usually needs to have the material disclosed below as the carrier material. In the fluid storage layer, these absorbent colloid materials can be Homogeneous or heterogeneous dispersion in a suitable fibrous matrix, also known as a carrier. Suitable carriers include: cellulose fibers, in the form of fluff or tissue, such as those commonly used in absorbent nuclei. Modified cellulose 'fibers' can also be used, such as hardened cellulose fibers or viscose fibers. Synthetic fibers can also be used and include cellulose acetate, polyvinyl fluoride, polygasified vinylidene, acrylic plastic (for example: Orion), polyethylene ethyl ester, insoluble polyethylene glycol, Polyethylene, polypropylene, polyamide (for example: nylon), polyester, bicomponent fiber, tricomponent fiber, mixtures thereof and the like. The preferred synthetic and artificial fibers are those having a fineness of about 3 denier per silk to about 25 denier per silk, and more preferably 5 denier per silk to about 6 denier per silk. The carrier fiber may be a substrate of bristles, spin, ..m, melt-blowing, wet spinning, air spinning, or a combination of these manufacturing methods or a combination of such substrates. It is also preferable that the surface of the fiber is hydrophilic or treated to be hydrophilic. The storage layer can also include filling materials, such as perlite, diatomaceous earth, vermiculite, etc., which can reduce rehumidity. The storage layer may further contain a binding agent, including -13-
本紙張尺度適財國@家標準(CNS)A4規格咖χ 297 ) (請先閲讀背面之注$項再填寫本頁) 裝------- -訂 if —----- 經濟部智慧財產局員工消費合作社印製 167736 A7 經濟部智慧財產局員工消费合作社印製 五、發明說明(11) 括但不限於·‘乳膠、結合劑,其可以水溶液型式於貯存層 乾燥處理前喷至其上。 方吸收膠體材質不均—地分散於纖維狀基質中,則貯存 層可爲局部均質的,即:於貯存層之空間中具有一或數方 向之分散梯度。因此不均—性分散包括,例如:園繞吸收 膠體材質I纖維載體積層或吸收膠體材質之濃度與其他區 域不同之區域。 若有吸收膠體材質,則貯存層較佳爲含有5%至95%之 吸收膠體材質,較佳爲含5 %至5 〇 %,更佳爲8%至3 5 % 之吸收膠體材質。貯存層可進一步含有5%至95%之載體 纖維,較佳爲含9 5 %至5 〇 %,更佳爲含9 2 %至.6 5 %载體 纖維。 此處所使用之適當吸收膠體材質最常含有實質上水不溶 性,輕度交叉鏈結,郅份中和之聚合膠體材質。該材質接 觸水時會形成水凝膠。此等聚合物材質可由可聚合,不飽 和性含酸單體製備而得β適合用以製備本發明使用之吸收 膠體材質 < 不飽和性酸性單體包括彼等條列於美國專利第 4,654,039號(Brandt等人)於1987年3月31曰公佈且於1988 年4月19日再公佈於RE 32f 649中者。較佳之單體包括丙.烯. 酸’甲基两烯酸,及2 -丙烯醯胺-2 -甲基丙磺酸。丙締酸 本身爲特別Μ佳於製備超吸收材質者,其亦具有,,天然" 透明度,若所要求之透明度不太高時,其雖非爲最適者, 但亦可接受。 不論可形成水凝膠之聚合吸收膠體材質之基本聚合物成 -14- 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) (請先閲讀背面之注意事項再填寫本頁) V裝 βτ. ο· 4 6773 6 A7 B7 五、發明說明(12) 份性質如何,此等材質一般均具輕度之交叉鏈結。交叉鏈 結可使水凝膠形成性聚合物膠體材質成為實質上水不溶性 者,且交又鏈結因此部份決定膠體體積且可得知由此等聚 合膠體材質所形成之水凝膠的聚合物特性^適合的交鏈劑 為此等技藝中所熟知且包括,例如:彼等更詳細說明於美 國專利第4,〇76,663 (Masuda等人)中,公布於1978年2月28 曰者。較佳之交鏈劑為不飽和單或多羧酸與聚醇類形成之 二或聚酯類,二丙烯醯胺類及二或三烯丙基胺類,其他較 ,交鏈劑為甲烯·二丙烯醯胺,三羥甲醇丙烷三两婦 酸酯,及三烯丙基胺類。交鏈劑之含量一般為所形成之水 凝膠形成性聚合物材質之約〇〇〇1莫耳百分比至5莫耳百分 比。更佳者,交鏈劑之含量為所形成之水凝膠形成性聚合 物材質之約0.01莫耳百分比至3莫耳百分比。 泫fe度父叉鏈結,水凝膠形成性聚合膠體材質通常以其 邛岛中和之型式使用。為達本發明之目的,若用以形成聚 合物之至少25莫耳百分比,且較佳為至少5〇莫耳百分/ 之單體為經過鹽形成性陽離子中和之含酸基因之單體,和 視此等材質為經部份中和者。適當的鹽形成性陽離子包括 鹼金屬,銨,經取代之铵及胺類。所使用之經中和含酸.基 因之單體之總百分比於本文中稱為π中和度,,。 雖然於先前技藝中揭示之此等吸收勝體材質典型者係 顆粒型式,但於本發明中之吸收膠體材質可呈非顆粒戈 式,例如呈大型結構,例如:纖維,片狀或條狀或呈適入 於披覆(例如:於硬化之前)之型式或為黏著物質之一部 比 則 呈 型 (請先閱讀背面之注意事項再填寫本頁) .'裝This paper is suitable for the country of wealth @ 家 standard (CNS) A4 size coffee χ 297) (Please read the note on the back before filling in this page) Packing ----- -Order if ------- Economy Printed by the Consumer Cooperative of the Ministry of Intellectual Property Bureau 167736 A7 Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs V. Description of the invention (11) Including but not limited to · latex, binding agent, which can be sprayed in the form of an aqueous solution before the storage layer is dried Over it. The square absorption colloid material is unevenly dispersed in the fibrous matrix, so the storage layer may be locally homogeneous, that is, there is a dispersion gradient in one or several directions in the space of the storage layer. Therefore, non-uniform dispersion includes, for example, circularly wound absorbent colloid material I, a fiber-containing volume layer, or an area where the concentration of the absorbent colloid material is different from other regions. If there is an absorbent colloid material, the storage layer preferably contains an absorbent colloid material of 5% to 95%, preferably an absorbent colloid material of 5% to 50%, more preferably 8% to 35%. The storage layer may further contain 5% to 95% of carrier fibers, preferably 95% to 50%, and more preferably 92% to .65% of carrier fibers. The appropriate absorbent colloid material used here most often contains a polymer colloid material that is substantially water-insoluble, mildly cross-linked, and neutralized by weight. This material forms a hydrogel when exposed to water. These polymer materials can be prepared from polymerizable, unsaturated acid-containing monomers. Β is suitable for the preparation of absorbent colloidal materials used in the present invention < unsaturated acidic monomers including them are listed in U.S. Patent No. 4,654,039 (Brandt et al.) Published on March 31, 1987 and republished in RE 32f 649 on April 19, 1988. Preferred monomers include propylene. Acid 'methyldienoic acid, and 2-acrylamido-2-methylpropanesulfonic acid. Acrylic acid itself is particularly good at preparing superabsorbent materials, and it also has, natural " transparency. If the required transparency is not too high, it is not the most suitable, but it is also acceptable. Regardless of the basic polymer composition of the polymer-absorbent colloid material that can form a hydrogel -14- This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) (Please read the precautions on the back before filling this page ) V device βτ. Ο · 4 6773 6 A7 B7 V. Description of the invention (12) What is the nature of these materials, these materials generally have mild cross-links. Cross-linking can make the hydrogel-forming polymer colloidal material substantially water-insoluble, and the cross-linking also partially determines the colloid volume and can know the polymerization of the hydrogel formed by such polymer colloidal materials Physical properties: Suitable crosslinkers are well known in these arts and include, for example, they are described in more detail in US Patent No. 4,076,663 (Masuda et al.), Published February 28, 1978. Preferred cross-linking agents are di- or polyesters of unsaturated mono- or polycarboxylic acids and polyalcohols, diacrylamidines and di- or triallyl amines. Others, the cross-linking agent is methylene. Dipropenamide, trimethylolpropane trisuccinic acid esters, and triallylamines. The content of the cross-linking agent is generally from about 0.001 mole percent to 5 mole percent of the hydrogel-forming polymer material formed. More preferably, the content of the cross-linking agent is from about 0.01 mole percent to 3 mole percent of the hydrogel-forming polymer material formed.泫 fe is a parent fork chain, and the hydrogel-forming polymer colloid material is usually used in its island-neutral form. For the purpose of the present invention, if the monomer used to form the polymer is at least 25 mole percent, and preferably at least 50 mole percent / monomer is an acid gene-containing monomer neutralized by a salt-forming cation , And regard these materials as those that are partially neutralized. Suitable salt-forming cations include alkali metals, ammonium, substituted ammonium, and amines. The total percentage of neutralized acid. Gene-containing monomers used is referred to herein as the degree of neutralization,. Although these absorbent materials disclosed in the prior art are typically granular, the absorbent colloidal materials in the present invention may be non-granular, such as large structures such as fibers, flakes or strips, or It is suitable for coating (for example: before hardening) or part of the adhesive substance (please read the precautions on the back before filling this page).
• t— H I A. 本紐尺Μ財關家鮮(CNS〉A4規格(i -15- 經濟部智慧財產局員工消費合作社印製 6 7736 A7 --—--- B7______ 五、發明說明(13) 份。大型結構之製備可藉由將顆粒狀之吸收膠體材質變成 聚集體’以適當之交鏈劑處理該聚集材質,将經處理之聚 集體壓縮使之密實並形成連續之塊狀,並再將壓縮之聚集 體加以硬化以使交鏈劑與顆粒狀吸收硬體材質反應以生成 複合’多孔狀之吸收性大型結構。此等,多孔狀,具吸收 '性之大型結構揭示於,例如,美國專利第5,1〇2,597號 (R〇e等人)中,其公布於1992年4月7曰。 d.視需要之鑪雒屉 根據本發明視需要包覆於吸收核心中之成价乃是鄰近 於’且典型地位於野存層下方之纖維層。此下方之纖維層 典型地提供與第二流體分散層相同之功能。 e·其他視需要之成价 根據本發明之吸收核心可包括其他視需要之成份其通常 存在於吸收網中。例如:強化疏紡棉布可置於吸收核心之 個別層中,或個別層間。此等強化疏紡棉布應爲不會造成 流禮傳送界面阻礙的構造,特別是若其置於吸收核心之個 別層間時。由於熱鍵結通常可提供結構上之完.整性,故根 據本發明’該強化疏紡棉布並非吸收體結構所必需者。 另一種根據本發明可包括於吸收核心且較佳爲靠近或爲 第一或第二流體分散層之一部份之成份爲氣味控制劑。典 型之活性碳披覆於特別適合之沸石,矽膠或黏土材質上或 其他氣味控制劑可視需要併入吸收核心中。 这收核心之物理特性 吸收核心一般無延長性及彈性,然可,其可變成有延長 -16- i紙張尺度適用中园國家標準(CNS)A4規格(21〇 χ 297公爱〉 ----- <請先閲讀背面之注意事項再填寫本頁> 、裝 I \τι// ·1 ϋ tmw J t n n .^1 n 1 J f 言 产—v 經濟部智慧財產局貝工消費合作社印製 467736 A7 B7 五、發明說明(14) 性且視所選擇之製造材質亦可具有彈性°本文之後所使用 之"有延長性"一辭係指一種結構,其於外力作用下,例 如彼等發生於使用期間延力之方向延長或延分力之方向只 有單方向之延長。 本文之彼所使用之"有彈性H —辭係指有延長性之結構其 經過使其延長之力作用後,至少可回復至部份初始狀態。 吸收核心可經由一或數方向之皺化或打摺。以提供相當之 延長性,而選用彈性纖維於結構中可提供其彈性。 吸收核心較佳爲薄層a所欲之厚度小於5毫米,較佳爲 小於3毫米且更較佳爲0.8至1.8毫米,以使所得之物件亦 具有低厚度。由於使用透明或淡黃材質之頂層或底層,該 核心可特別易於進行偵測器狀態之檢查。 可提供偵測裝置之褲墊及衛生棉之非限制性實例包括彼 等由 The Procter & Gamble Company of Cincinnati,Ohio 製 造之:根據美國專利第4,324,246 : 4,463,045及6,004,893號 製造之具DriWeave® ALWAYS® ALLDAYS®褲墊;及根據 .美國專利第 4,342,314 ,4,463,045 ,4,556,146 ,B1 4,589,876,4,687,478,4,950,264,5,009,653,5,267,992, 及Re. 32,649號製造之具蝶翼之ALWAYS®超薄長迷嬉. (Maxi) : ALWAYS®標準迷嬉;具蝶翼之ALWAYS®超迷 嬉;具蝶翼之ALWAYS®迷嬉;具蝶翼之ALWAYS®超長 迷嬉;具蝶翼之ALWAYS®長超迷嬉;及具蝶翼之 ALWAYS®夜安迷嬉。 非限制性之具偵測裝置之唇間裝置實例説明於美國專利 -17- 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) (請先閱讀背面之注意事項再填寫本頁) 裝 467736 A7 B7 經濟部智慧財產局員工消費合作社印製 五、發明說明(1S) 5,762,644 ; 5,885,265 ; 5,891,126 ; 5,895,381 ; 5,916,205 ; 5,951,537 ; 5,964,689 ; 5,968,026 ; Des. 404,814 ;及 Des. 413,669 中。 非限制性之具偵測裝置及其塗佈器之止血栓實例説明於 美國專利第 4,726,805 ; 4,846,802 ; 4,960,417 ; 5,087,239 ; 5,279,541 ; 5,346,468 ; 5,348,534 ; 5,531,674 ; Ά. 5,566,435 號中。此外,該偵測裝置亦可置於手指插入性止血栓中。 血液偵測器 根據本發明之物件亦可包括至少一種用以4貞測血液之感 應器。本文中所使用之感應器”一辭定義爲一種紕件, 其含有一種或多種有反應的裝置,可適用於偵測一種或多 種目標物質(亦稱爲分析物)例如:微生物或相關之(生物) 分子(例如:酵素感應器,胞器感應器,組織感應器,微生 物感應器,免疫感應器,及化學或電化學感應器),此外 具有可提供該偵測之訊號給穿用者,看護者,或促動器之 能力。本文中提及血液時,典型之血液組成,例如:血紅 素或鐵亦當然可作爲分析物。"有反應的"一辭係指具有 與此等目標物質選擇性反應之能力。 有兩種感應器其具有不同之感度··生物感應器及化學/電. 化學感應器。一般生物感應器之作用係藉由提供一種專一 性結合之裝置,並再偵測具生物活性之目標分析物.。此方 法中,生物感應器具有高度選擇性,其至當分析物存在於 多種化學及生物性物體之混合物例如:陰道排出物中時。 另一方面,依賴化學反應裝置之電化學及化學感應器一般 -18- 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐〉 (請先閲讀背面之迮意事項再填寫本頁) V裝• t— HI A. Ben Niu M Cai Guan Jia Xian (CNS> A4 specification (i -15- printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 6 7736 A7 ------ B7______) 5. Description of the invention (13 ). For the preparation of large structures, the aggregated colloidal material can be transformed into aggregates by treating the aggregated material with a suitable cross-linking agent, and compressing the treated aggregate to make it dense and form a continuous block, and The compressed aggregates are then hardened to cause the cross-linking agent to react with the particulate absorbent hard material to form a composite 'porous, absorbent, large-scale structure. These, porous, absorbent, large-scale structures are disclosed in, for example, In US Patent No. 5,102,597 (Roe et al.), It was published on April 7, 1992. d. Furnace drawer as needed According to the present invention, the composition of the absorbent core is coated as needed. Valence is a fibrous layer that is adjacent to and typically below the wild layer. The fibrous layer below this typically provides the same function as the second fluid-dispersing layer. E. Other valences as needed The absorbent core according to the invention May include other ingredients as needed Exist in the absorbent web. For example, reinforced scrims can be placed in individual layers of the absorption core, or between individual layers. Such reinforced scrims should be structures that do not hinder the flow transmission interface, especially if they are placed Between individual layers of the absorbent core. Since thermal bonding usually provides structural integrity and integrity, according to the present invention 'the reinforced scrim is not required for the absorbent structure. Another type may be included in the absorbent according to the present invention. The core and preferably a component near or part of the first or second fluid dispersion layer is an odor control agent. Typical activated carbon is coated on a particularly suitable zeolite, silicone or clay material or other odor control agents are visible It needs to be incorporated into the absorption core. The physical characteristics of this absorption core generally have no elongation and elasticity, but it can be extended to -16-i paper size applicable to the China National Standard (CNS) A4 specification (21〇χ 297 Public Love> ----- < Please read the precautions on the back before filling in this page >, install I \ τι // · 1 ϋ tmw J tnn. ^ 1 n 1 J f Language—v Ministry of Economy Bureau of Intellectual Property Printed by Fei Cooperative 467736 A7 B7 V. Description of the invention (14) It can also be flexible depending on the manufacturing material chosen. The term "extensibility" used after this article refers to a structure that acts on external forces. For example, the extension of the direction of the extension force or the extension of the component force during use only occurs in one direction. The "flexible H" used in this article means "extensible structure, which has been passed through to make it After the prolonged force is applied, it can return to at least part of the initial state. The absorbent core can be wrinkled or discounted in one or several directions to provide considerable elongation, and the use of elastic fibers in the structure can provide its elasticity. The absorption core preferably has a desired thickness of the thin layer a of less than 5 mm, preferably less than 3 mm, and more preferably 0.8 to 1.8 mm, so that the obtained article also has a low thickness. Due to the use of a transparent or light yellow top or bottom layer, the core is particularly easy to check the status of the detector. Non-limiting examples of pant pads and sanitary napkins that can provide detection devices include those manufactured by The Procter & Gamble Company of Cincinnati, Ohio: DriWeave® ALWAYS® manufactured according to U.S. Patent Nos. 4,324,246: 4,463,045 and 6,004,893 ALLDAYS® pant; and according to U.S. Patent Nos. 4,342,314, 4,463,045, 4,556,146, B1 4,589,876, 4,687,478, 4,950,264, 5,009,653, 5,267,992, and Re. 32,649. : ALWAYS® standard fans; ALWAYS® with butterfly wings; ALWAYS® with butterfly wings; ALWAYS® with butterfly wings; ALWAYS® with butterfly wings; ALWAYS® with butterfly wings; and Butterfly wings ALWAYS® Good Night. A non-limiting example of a lip device with a detection device is described in US Patent-17- This paper size applies to Chinese National Standard (CNS) A4 (210 X 297 mm) (Please read the precautions on the back before filling in this Page) 467736 A7 B7 Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs. 5. Description of Invention (1S) 5,762,644; 5,885,265; 5,891,126; 5,895,381; 5,916,205; 5,951,537; 5,964,689; 5,968,026; Des. 404,814; and Des. 413,669. Non-limiting examples of thrombi with detection devices and applicators are described in U.S. Patent Nos. 4,726,805; 4,846,802; 4,960,417; 5,087,239; 5,279,541; 5,346,468; 5,348,534; 5,531,674; Ά. 5,566,435. In addition, the detection device can also be placed in a finger insertion tampon. Blood detector The article according to the invention may also include at least one sensor for measuring blood. The term "sensor" as used herein is defined as a piece of software that contains one or more reactive devices that can be used to detect one or more target substances (also known as analytes) such as microorganisms or related ( Biological) molecules (such as: enzyme sensors, organelle sensors, tissue sensors, microbiological sensors, immune sensors, and chemical or electrochemical sensors), in addition to providing a signal to the wearer, Caregiver, or actuator capabilities. When referring to blood in this article, typical blood components, such as heme or iron, can of course be used as analytes. "Reactive" means having the same Ability to selectively react with target substances. There are two types of sensors with different sensitivity. Biosensors and chemical / electrical. Chemical sensors. The function of general biosensors is to provide a specific combination of devices, and Detect biologically active target analytes. In this method, the biosensor is highly selective, and it can be used when the analyte is present in many chemical and biological objects. Compounds such as: in vaginal discharge. On the other hand, electrochemical and chemical sensors that rely on chemical reaction devices are generally -18- This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) (Please (Please read the notice on the back before filling this page)
I I I I J\l/ 467736 A7 B7 經濟部智慧財產局員工消費合作社印製 五、發明說明(1β) 不具有生物感應器之高選擇性或訊號擴大特性,但其具有 南信賴度’不昴貴,即:可使用於日用產品,且通常經過 良好之確立’即:證明其使用於人類皮膚上安全無虞。通 常目標分析物是在含有複雜生物性及其他成份之複雜混合 物中之次要成份。因此,於許多應用之生物感應器中,必 兩可彳貞測目標,分析物至十億分之幾,兆分之幾或其至更低 濃度〇 根據本發明之衛生吸收物件含有呈特別選擇之化學組合 物型式之血液偵測裝置。該化學组合物含有選自於癒創勝 或四Τ基聯苯胺或其混合物。其被氧化而反應之顏色指示 成份及選自於過氧化物或過酸或其混合物之氧化性成份。 該氧化性成份在此等物件之一般貯存環境下(例如:於浴 室中之溫暖高濕環境)必需爲安定且不敏感者。若該氧化 .性成份爲過氧化物,則可採用物理化學安定化例如:利用 環狀糊精或金屬鉗合劑。若爲過酸,特別是較佳爲epta_ 献酿亞胺基-過氧己酸,則已發現較不需此等安定化。氧 化性成份亦必需不被衛生物中之一般成份及穿用時產生之 濕氣(例如:汗液)或所吸收之不含血液成份之陰道排出物 所活化。同樣之條件亦當然適用於顏色指示劑。 除了各成份之安定化之外,亦需避免兩種成份之過早或 突然反應。此可藉由將其物理性地分開,使一種成份位於 根據本發明之衛生物件中某一層之表面且另一種成份位於 孩層;另一面。或者,可將一種成份置於某一層之朝穿用 者表面且另一種成份置於另一層之朝穿用者表面或置於同 -19- 本紙張尺度週用f國國家標準(CNS)A4規格⑽x 297公爱〉 (請先閱讀背面之注意事項再填寫本頁) 、丨裝 ----訂i丨丨丨 Ο 4 67736 A7 B7 五、發明說明(17) 經濟部智慧財產局員工消費合作社印製 層之朝衣物表面。最後,—種成份可被置於某一層内 部、’例如:中央吸收核心之内部而另一種成份至少置於該 層之#刀表面上。將兩種成份置於同一層者亦可應用其他 型式2例如:長條,點狀或其他形狀。該等成份之一或二 者可王粉末,液體或具黏性可良好披覆之混合物型式。 .分開二成份亦可藉由將其中至少一種例如:氧化性成份 芫全分離至物件外(並因此而遠離另一成份),例如以噴霧 或液體或粉末之型式,於物件使用後再塗佈於其上以進行 所欲心偵測。此等偵測系統特別適用於緊貼肌膚且可隨馬 捅沖走之物件(例如:止血栓或唇間物件)β此等系統必需 考量分_成份之安定性及與婦女之再生性器官接觸之材質 的調節性。 顏色指示劑及氧化性物質二者均僅於水溶液中有反應 性。因此其僅在溶於陰道排出物及被所存在乏血液致活時 才可開始反應。爲了加速並推動其溶解,其較佳爲含有表 面活性的物質,例如:界面活性劑,較佳爲非離子性界面 活性劑,或聚乙二醇或其混合物。該表面活性物質需置於 液體到達該二成份前即可被潤濕之處。 極佳之組合物質含有epta_酞醯亞胺-過氧己酸及癒創. 膠。癒創膠係發現於癒創木或南美癒創木木材之樹脂(主 要生產於墨西哥或西印度)。癒創膠傳統上係作爲食物之 調味劑(並因此具有人類安全使用之長久歷史)且已知具有 指示血液或血紅素存在特別是在糞中之能力。根據本發 明,癒創膠樹脂爲較佳者,维然一種或所有活性成份(無 -20- 本紙承尺度適用令國國家標準(CNS)A4規格(210 X 297公釐〉 (諝先閲讀背面之注意事項再填窝本頁) •裝IIIIJ \ l / 467736 A7 B7 Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs V. Invention Description (1β) Does not have the high selectivity or signal expansion characteristics of biosensors, but it has the reliability of South Korea. : Can be used in daily products and is usually well established 'that is, it proves safe for use on human skin. Usually the target analyte is a secondary component in a complex mixture containing complex biological and other components. Therefore, in many applications of biosensors, the target must be measured, the analyte to parts per billion, parts per trillion or lower. The sanitary absorbent article according to the present invention contains a special selection. Chemical composition type blood detection device. The chemical composition contains a member selected from the group consisting of guaiacene or tetra-T-benzidine or a mixture thereof. The color-indicating component which is oxidized and reacts, and the oxidizing component selected from peroxide or peracid or a mixture thereof. The oxidizing ingredient must be stable and insensitive under the general storage environment of such objects (for example, warm and humid environment in a bathroom). If the oxidizing component is a peroxide, physicochemical stabilization can be used, for example, using a cyclodextrin or a metal clamp. If it is a peracid, particularly preferably epta-donor imino-peroxyhexanoic acid, it has been found that such stabilization is less needed. The oxidizing ingredients must also not be activated by general ingredients in hygiene and by moisture (such as sweat) generated during wearing or absorbed vaginal discharge containing no blood. The same conditions apply, of course, to color indicators. In addition to the stabilization of the ingredients, it is also necessary to avoid premature or sudden reactions of the two ingredients. This can be achieved by physically separating one component on the surface of one layer and another component on the child's layer in the sanitary article according to the present invention; the other side. Alternatively, one component may be placed on the wearer-facing surface of another layer and the other component may be placed on the wearer-facing surface of another layer or on the same paper as the national standard (CNS) A4 Specifications ⑽ x 297 Public Love> (Please read the precautions on the back before filling out this page), 丨 installation ---- order i 丨 丨 丨 〇 4 67736 A7 B7 V. Description of invention (17) Consumption by employees of the Intellectual Property Bureau of the Ministry of Economic Affairs Co-operative printed layer facing garment surface. Finally, one component can be placed inside a layer, e.g., inside the central absorbent core and another component at least on the #knife surface of the layer. If two components are placed on the same layer, other types 2 can be applied, for example: strip, dot or other shapes. One or both of these ingredients can be powdered, liquid or viscous and can be coated well. Separating the two components can also be achieved by separating at least one of them, for example: the oxidizing component, from the object (and therefore away from the other component), such as in the form of a spray or liquid or powder, and then coating the object On it for the desired detection. These detection systems are particularly suitable for objects that are close to the skin and can be washed away with the stables (such as tampons or lip objects) β These systems must consider the stability of the ingredients and the contact with women's reproductive organs Adjustability of material. Both color indicators and oxidizing substances are reactive only in aqueous solutions. Therefore it can only start to react when it is dissolved in vaginal discharge and activated by the presence of deficient blood. In order to accelerate and promote its dissolution, it is preferably a surface-active substance, such as a surfactant, preferably a nonionic surfactant, or polyethylene glycol or a mixture thereof. The surface-active substance needs to be placed where the liquid can be wetted before it reaches the two components. Excellent combination of substances containing epta_phthalimide-peroxyhexanoic acid and guaiac. Gum. Guaicene is a resin found in guaiac wood or South American guaiac wood (mainly produced in Mexico or West India). Guaia gum has traditionally been used as a flavoring agent for food (and therefore has a long history of safe human use) and is known to have the ability to indicate the presence of blood or heme, especially in feces. According to the present invention, guaiac resin is better, one or all of the active ingredients (no -20- this paper bears the national standard (CNS) A4 specification (210 X 297 mm) (谞 read the back first) Note for refilling this page) • Packing
n n H 一 =OJ· I n I ο 467736 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明(18) 論其為天然或人工衍生者)均可用以取代該樹脂*最佳之 已知活性成份為癒創木酚(0HC6H40CH3,CAS 90-05]), 黃色癒創木酸及(11夫喃)-瘡創木素。 該成份可先溶於溶液中’再以披覆或噴霧法進行塗佈。 此處之溶劑可為水或有機溶劑。若需要去除溶劑,則可以 低於1 0 0 ec之溫度將此等溶劑,特別是含水者予以蒸發。 額外之偵測器 於本發明之一特別較佳具體實例中,該物件除了血液债 測器外,尚含有另一個別活化且功能獨立之感應器以偵測 生理期之接近。 特別用以預測生理期之血液偵測器明顯地無法達到百分 之百準確度。首先,指示劑本身必需僅對血液偵測具有高 準確度,即其應對其他存在之物質不敏感。另一方面,需 要高感度以债測出低量之血液’即:在其可被肉眼察覺之 前。此二者必需取得平衡- · 再者’血液(潛血)之存在已被熟知為生理期接近之訊 號。然而受傷或病理狀態亦可引起陰道排出物中有少量 血液存在。因此’衛生物件中需要額外之指示劑以提供生 理期接近之第二訊號。此等訊號可藉由,例如:生理期前 數天中陰道排出物之pH值變化來提供。此外,亦可使用 荷爾蒙’例如:黃體激素或動情素作為生理期預測之另一 種指示劑。 此處最佳者係為Ρ η感應器,其亦可為顏色變化指示 劑。ρ Η感應器已被熟知且可購得’例如:購自丁匕Merck -21 - 本紙張尺度適用中國國家標準(CNS)A4規格(210 x 297公釐) <請先閱讀背面之注意事項再填寫本頁) -丨裝! |_訂·1! 467736 A7 B7 經 濟 部 智 慧 財 產 局 消 費 合 作 社 印 製 五、發明說明(19)nn H 一 = OJ · I n I ο 467736 Printed by the Consumers ’Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs A7 B7 V. Description of the invention (18) It is a natural or artificial derivative) can be used to replace the resin * the best already It is known that the active ingredients are guaiacol (0HC6H40CH3, CAS 90-05]), yellow guaiac acid and (11furan) -acne lignin. This component can be dissolved in solution 'and then applied by coating or spraying. The solvent here may be water or an organic solvent. If solvents need to be removed, these solvents, especially those containing water, can be evaporated below a temperature of 100 ec. Additional Detector In a particularly preferred embodiment of the present invention, in addition to the blood debt detector, the object contains another sensor that is activated and functions independently to detect the approach of the physiological period. Blood detectors, especially for predicting the physiological period, obviously cannot achieve 100% accuracy. First, the indicator itself must be only highly accurate for blood detection, that is, it should not be sensitive to other substances present. On the other hand, a high sensitivity is needed to detect a low amount of blood ', that is, before it can be detected by the naked eye. The two must be balanced-and the presence of 'blood (occult blood) has been known as a signal that the physiological period is approaching. However, injuries or pathological conditions can also cause a small amount of blood in the vaginal discharge. Therefore, an additional indicator is needed in the 'sanitary article' to provide a second signal that the physiological period is approaching. These signals can be provided, for example, by changes in the pH of vaginal discharge during the first few days of the physiological period. In addition, hormones such as progesterone or estrin can be used as another indicator for predicting the physiological period. The best here is a P η sensor, which can also be a color change indicator. ρ Η sensors are well-known and commercially available '. For example: purchased from Ding Merck -21-This paper size applies to China National Standard (CNS) A4 (210 x 297 mm) < Please read the notes on the back first Fill out this page again)-丨 Install! | _Order · 1! 467736 A7 B7 Printed by Consumer Affairs Bureau, Intellectual Property Agency, Ministry of Economic Affairs V. Description of Invention (19)
Company, Darmstadt, Germany。此處具有充分確立之安全Company, Darmstadt, Germany. Well-established security here
性’極佳之pH感應器為胭脂蟲酸’其作為食品染劑,但 在pH 4至pH 7之範園内可變色。胭脂酸係分子式c22H2c)〇i3 之三環化合物D 無論使用何種額外感應器,倘若其作為顏色變化指示 劑,其較佳為分開放置,例如:置於物件中.之不同區域(當 然需置與可與陰道排出物接觸之處)。或者,其可與血液 偵測之顏色指示劑放在一起《於此方法中,所使用之顏色 指示劑可提供多色彩之指示。 例如:就癒創膠而言,其可使顏色變藍且一 1)11感應器可 使顏色變成例如:紅色,則混合之顏色感應器(藍色及紅色) 會變成紫色以使提供對生理期接近預測之高準確性及時間 趨近性。不同之顏色變化(例如只有藍色或只有紅色)則個 別和.示距生理期仍有一段時間或有潛在之健康問題(單獨 P Η改變可能,但不必然為感染之訊號,而單獨之血液指 示可说’但不必然為創傷之訊號)。針對此等變化,衛生 物件之包裝應包括對使用者之指示,告知其應求醫以評估 是否有任何嚴重之健康問題(病理狀態)存在。當然,若無 顏色變化則表示距下次生理期仍有一段時問。 除了電化學感應器可作為血液偵測器之輔助外,生理期 周期(即:2 8天全周期)之周期性荷爾蒙使其特別可用以了 解個人正處在周期中之何時期。此長期被用於受孕之評 估,但根據本發明之應用可超出目前之荷爾蒙應用範圍, 將之用於預測排卵及懷孕。例如:黃體激素於生理期來臨 (請先閱讀背面之注意事項再填窝本頁) -22-The excellent pH sensor is carminic acid, which is a food dye, but it can change color in a range of pH 4 to pH 7. Nopalic acid tricyclic compound D of molecular formula c22H2c) 〇i3 No matter what kind of additional sensor is used, if it is used as an indicator of color change, it is better to place it separately, for example: in different areas of the object Contact with vaginal discharge). Alternatively, it can be put together with a color indicator for blood detection. In this method, the color indicator used can provide a multi-color indication. For example, for guaiac, it can make the color blue and a 1) 11 sensor can change the color to, for example: red, the mixed color sensor (blue and red) will turn purple to provide physiological The period is close to the high accuracy and time proximity of the forecast. Different color changes (for example, only blue or only red) are individual and. There is still a period of time from the physiological period or there are potential health problems (individual P Η change may be, but not necessarily a signal of infection, but blood alone Instructions can say 'but not necessarily a sign of trauma). In response to these changes, the packaging of hygienic articles should include instructions to the user informing them to seek medical attention to assess whether there are any serious health problems (pathological conditions). Of course, if there is no color change, it means that there is still some time before the next physiological period. In addition to electrochemical sensors that can be used as a supplement to blood detectors, the cyclic hormones in the physiological cycle (ie, a full 28-day cycle) make it particularly useful for understanding when an individual is in the cycle. This has long been used in the assessment of conception, but the application according to the invention can go beyond the current hormonal application and use it to predict ovulation and pregnancy. For example: Progesterone comes during the physiological period (please read the precautions on the back before filling this page) -22-
467736 經濟部智慧財產局負工消費合作社印製 Α7 Β7 五、發明說明(20) 前達高峰並隨即驟降。動情素於生理期來臨前亦下降。因 此’與其他預測劑,例如:血液偵測或P Η指示併用,分析 此兩種荷爾蒙之任一種可對生理期之開始及存在提供可信 之預測。此%何爾蒙達到高峰之時間,配合其隨後之下 降,可高度準確地標示出生理期前之時間。 此等荷爾蒙感應器之唯一潛在缺點係其伴隨之成本及複 雜性。由於無法簡易地目視,故其於大量物件之量產上並 非極具吸引力。因此,使用荷爾蒙偵測於生理期之預測上 較隹爲結合金液偵測及/或ρ Η偵測以改善其個.別分開使用 時之預測準確度。 荷爾蒙之利用亦可用於周期中之其他目標點。濾泡刺激 素(FSH)於排卵約一週前達到高峰,其可較於排卵期達到 陡峭高峰之黃體激素分析爲懷孕計劃提供更早期之時機。 若只依賴黃體激素之分析可能會錯失2至3天之受孕期。 因此’此處爲要診斷排卵,較佳乃測定遽泡刺激素及黃體 激素二者及動情素。 濾泡刺激素升高至趨近衡量時即爲更年期接近之訊號。 此可用於更年期之健康進路規劃,例如:荷爾蒙替代療 法,營養更換,及骨質疏鬆之檢查》 根據本發明之衛生物件可含有數種額外之感應器及债測 器系統’其可例如··指示或預測個體之健康相關問題。此 等額外之感應器系統主要係用於使用於看護狀態之衛生物 件中β 一般而言,此等額外之系統或生物感應器含有一種 辨識元件,或分子辨識元件’其可用以偵測特殊之分析 -23 - 本紙張尺度適用中國國家標準(CNS)A4規格(210 * 297公釐) (請先閲讀背面之注意事項再填寫本買) -I 111[111 . _ Ilf— — — — .Ύ . 46773b A7 B7 經濟部智慧財產局員工消費合作社印製 五、發明說明(21: 勿。孩辨識7C件可爲生物衍生性物質,.例如:酵素或一系 列酵素;抗體;膜接受器蛋白質;DNA ;胞器;天然或 人工細胞膜;完整或部份存活或不.存活之細菌,植物或動 物細胞;或一片植物或哺乳動物之组織,且其通常具有可 與特定目標分析物作用之功能。該辨識元件係用以選擇性 地辨識分析物並產生物理化學訊號以作爲輸出訊號之基 礎。 生物感應器可包括生物催化性生物感應器,及生物親和 性生物感應器。於生物催化性生物感應器之具.體實例中, 生物辨識元件具有’’生物催化性"且可包括酵素,胞器, 植物或哺乳動物組織片,或全細胞,選擇性結合位置”可 再生"(即:,可於偵測過程中再度使用),以對輸入之訊號產 生顯著放大之效果。例如此等之生物催化感應器一般可用 以即時,連續之感應。 生物親和性生物感應器一般適用於細菌,病毒,及毒素 且包括化學接受器基底之生物感應器及/或免疫學之生物 感應器(即:免疫感應器)^化學接受器係爲複.雜之生物分 子巨型组合體其部份藉用生物體對其環境中之化學物質之 高度選擇性感應能力。化學接受器基底之生物感應器包含. 一種或多種天然或人工之化學接受器伴隨一種可提供生物 性目標分析物之存在或濃度訊號(視覺的,電予的,等)之 裝置。化學接受器可包括全部或部份神經束(例如來自於 觸角或其他感應器官)及/或全部或部份之天然或人工細胞 膜。另一方面,免疫感應器之生物辨識元件一般爲抗體。 -24- 本紙張尺度適用中國國家標準(CNS)A4視格(210 X 297公爱) — — — — —---- I一,/ · 11 ~* — — 一 I ---- - I I I (請先閱讀背面之注意事項再填寫本頁) G7 73〇 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明(E) 抗體具有高度專一性且可針對細菌,病毒,微生物斷片 (例如:細菌細胞壁,寄生蟲卵或其—部份等),及大型生 物分子而製造。於任何實例中,生物親和性感應器一般爲 不可逆的,因爲生物感應器之接受器位置暴露於生物性目 標分析物中將被飽和。於相當之具體實例中,生物催化性 及生物親和性生物感應器可互相結合。生物催化性及生物 親和性生物感應器系統更詳細説明於JourT1al nf Chromatography, 510 (1990) 347-354 及 Kirk-OtWr467736 Printed by the Consumers' Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs Α7 Β7 V. Description of Invention (20) The peak came before and then dropped sharply. Estrogen also decreases before the onset of the physiological period. Therefore, 'combined with other predictors, such as blood tests or P Η instructions, analysis of either of these two hormones can provide credible predictions of the onset and existence of the physiological period. The time when this% hormone reaches its peak, coupled with its subsequent decline, can mark the time before the physiological period with high accuracy. The only potential disadvantage of these hormone sensors is their attendant cost and complexity. Because it is not easy to see visually, it is not very attractive for mass production of a large number of objects. Therefore, the use of hormonal detection in the prediction of the physiological period is better than combining the detection of gold liquid and / or ρ Η to improve the accuracy of the prediction when it is used separately. The use of hormones can also be used for other target points in the cycle. Follicle stimulating hormone (FSH) peaks about a week before ovulation, which can provide an earlier opportunity for pregnancy planning than luteinizing hormone analysis, which reaches a steep peak during ovulation. Analysis that relies solely on progestin may miss the gestation period of 2 to 3 days. Therefore, 'to diagnose ovulation, it is preferable to measure both vesicular stimulating hormone, luteinizing hormone, and estrogens. When the follicle stimulating hormone is approaching the measurement, it is a signal of menopause. This can be used for menopausal health pathway planning, such as: hormonal replacement therapy, nutrition replacement, and osteoporosis inspection. The sanitary article according to the present invention may contain several additional sensors and debt detector systems. Or predicting an individual's health-related issues. These additional sensor systems are mainly used in sanitary articles in the care state. Generally speaking, these additional systems or biosensors contain an identification element, or molecular identification element, which can be used to detect special Analysis-23-This paper size is in accordance with Chinese National Standard (CNS) A4 (210 * 297 mm) (Please read the precautions on the back before filling out this purchase) -I 111 [111. _ Ilf— — — —. — 46773b A7 B7 Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs. 5. Description of the invention (21: No. The child recognizes that the 7C pieces can be biologically derived substances, such as: enzymes or a series of enzymes; antibodies; membrane receptor proteins; DNA; organelles; natural or artificial cell membranes; whole or partial survival or not. Surviving bacteria, plant or animal cells; or a piece of plant or mammalian tissue, which usually has the function of interacting with a specific target analyte The identification element is used for selectively identifying the analyte and generating a physicochemical signal as a basis for the output signal. The biosensor may include a biocatalytic biosensor And bio-affinity biosensors. In the case of biocatalytic biosensors, the biometric element is `` biocatalytic '' and may include enzymes, organelles, plant or mammalian tissue pieces, or Whole cell, selective binding position "renewable" (that is, it can be used again in the detection process) to produce a significant amplification effect on the input signal. For example, these biocatalytic sensors are generally used for real-time, Continuous sensing. Bioaffinity biosensors are generally applicable to bacteria, viruses, and toxins and include biosensors based on chemical receptor substrates and / or immunological biosensors (ie: immunosensors) ^ Chemical receptor systems The complex of complex biomolecules is partially borrowed from the organism's highly selective sensing ability for chemicals in its environment. Biosensors on the base of chemical receptors include one or more natural or artificial chemical acceptances The device is accompanied by a device that provides a signal (visual, electrical, etc.) of the presence or concentration of a biological target analyte. The organ may include all or part of a nerve bundle (such as from antennae or other sensing organs) and / or all or part of a natural or artificial cell membrane. On the other hand, the biometric element of an immunosensor is generally an antibody. -24- This paper size is applicable to the Chinese National Standard (CNS) A4 viewing grid (210 X 297 public love) — — — — —---- I I, / · 11 ~ * — — I I -----III (please first Read the notes on the back and fill in this page) G7 73〇 Printed by the Consumers ’Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs A7 B7 V. Description of the invention (E) Antibodies are highly specific and can be directed against bacteria, viruses, and microbial fragments (for example: bacteria Cell walls, parasite eggs or parts thereof), and large biomolecules. In any instance, the bioaffinity sensor is generally irreversible because the receptor location of the biosensor will be saturated when exposed to the biological target analyte. In quite specific examples, biocatalytic and bioaffinity biosensors can be combined with each other. Biocatalytic and bioaffinity biosensor systems are described in more detail in JourT1al nf Chromatography, 510 (1990) 347-354 and Kirk-OtWr
Encyclopedia of Chemical Technology 4^(1 (1992) » John Wiley & Sons,NY 中。 本發明之生物感應器較佳亦可偵測與迫近(即,即將出 現徵兆)或現有之人類系統性疾病狀態有關之生物活性分 析物,包括致病性細菌,寄生蟲,病毒,眞菌例 如:Candida albicans,病原體之抗體,及/或微生物產生之 毒素。此外,生物感應器亦可追踪與迫近或現有之局部健 康問題有關之生物活性分析物,例如:壓力蛋白質(如:胞 漿素)及IL-1 α(間白素1 -阿法)其可爲臨床之皮膚刺激或 發炎出現之前導訊息。於較佳之具體實例中,生物感應器 具有預警感應器之功能,其可於臨床徵兆出現之前,對穿. 用者或看護者之即發狀況加以偵測並產生訊號。此可提供 時間對穿用者施用預防性藥物或進行補救性治療,其若無 法避免,亦可顯著降低該病症之嚴重性及發作期。更甚 者,生物感應器可藉由偵測穿用者之身體廢棄物中生物性 目標分析物之存在,而可偵測出表面,例如皮膚與生物感 -25- 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) I u i n n -· n VI It i I 訂--------- (請先閱讀背面之注意事項再填寫本頁) ^7 736 A7 B7 五、發明說明(23) 應器接觸之殘留污染物,並提供適當之訊號。 (請先閲讀背面之注意事項再填寫本頁) 由辨識元件(一個或多個)所產生之訊號係以視覺化方式 傳遞給穿用者或看護者,例如:經由人眼可見之顏色變 化。該訊號可為定性(例如:指示生物性目標分析物之存在) 或定量(即:測定出生物性目標分析物之含量或濃度)。於 任何.實例中,訊號最佳為持久的,即在長時間中穩定且可 判讀(典型地需至少等於該物件之使用時間)。更甚者,該 感應器可適用於生物性目標分析物之濃度僅高於或低於預 設之閥值時(例如:於生物性目標分析物於身體廢棄物中正 常存在之狀沉下)偵測及/或發出訊號。 經濟部智慧財產局員工消費合作社印製 如同上述,本發明之生物感應器適合偵測之目標分析物 為致病性微生物例如與人類腸胃疾病有關之致病性微生 物,特別是彼等導致下痢者。頃已發現嚴重之慢性下痢可 造成體重減輕及永久之生理及心理障礙。生物感應器6 0 可偵測之致病細菌之非限制性名單包括下列任何一種 Escherichia coli ( —般所知為E. Coli)之致病性菌株;沙門 氏菌株(Salmonella),包括 S. typhi,S. paratyphi,S. enteriditis,S. typhimurium,及 S. heidelberg ;忘贺氏 (Shigella)菌株,例如:Shigella sonnei,Shigella flexneri, Shigella boydii,及 Shigella dysenteriae ; Vibrio cholerae ; Mycobacterium tuberculosis : Yersinia enterocolitica ; Aeroraonas hydrophila ; Plesiomonas Shigelloides ; Campylobacter 菌株,例如:C. jejuni 及 C. coli ; Bacteroides fragilis ;及 Clostridia 菌.株,包括 C. septicum.,C, -26- 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) :7 3 咚 A7 __B7 _ 五、發明說明(24) perfringens,C,botuUnutii,及 C‘ difficile。適合 Ί貞測 E. coli 之商業化可得生物感應器之非限制性實例係購自AndCare, Inc, of Durham, NC 之試驗套組 #4001。ABTECH,Scientific, Inc., of Yardley,PA提供商品编號爲 BB Au-1050.5-FD-X之 "生物分析性生物轉換器”其可藉由共價性固定於其表面 上之多肽類,酵素,抗體或DNA片斷而提供生物專一 性。其他適合之微生物生物感應器説明於美國專利第 5,869,272(革蘭氏陰性菌);5,795,717 (Shigella); 5,830,341 ; 5,795,453 ; 5,354,661 ; 5,783,399 ; 5,840,488 ; 5,827,651 ; 5,723,330 ;及 5,496,700 號中。 本發明之生物感應器適合偵測之目標分析物亦可爲病 毒。此可包括引發下瘌之病毒,例如:旋轉病毒,或其他 病毒,例如:鼻病毒及人類免疫不全病毒(HIV)。一種適 於偵測HIV之生物感應器示例説明於上述提及之美國專利 第 5,830,341 及 5,795,453 中。 經濟部智慧財產局員工消費合作社印黎 (請先閲讀背面之注意事項再填寫本頁) 在另一具體實例中,本發明之生物感應器適合偵測之目 標分析物亦可爲寄生蟲,特別是彼等於其生活史中之某些 時期棲息於腸胃道中者。此等寄生蟲可包括原蟲類,蠕蟲 類,及其他腸胃寄生蟲。可偵測之其他寄生蟲實例包括痢· 疾阿米巴(其引起阿米巴痢疾),克魯士氏錐蟲(trypana cruzi)(其引起卻格司病),及鐮狀癌蟲(piasmodium falciparum)。 再其他之具體實例中,本發明之生物感應器適合偵測之 目標分析物爲眞菌,例如:Candida albicans。除此之外, -27- 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐)Encyclopedia of Chemical Technology 4 ^ (1 (1992) »John Wiley & Sons, NY. The biosensor of the present invention preferably can also detect and approach (ie, imminent signs) or existing human systemic disease states. Relevant biologically active analytes include pathogenic bacteria, parasites, viruses, and fungi such as Candida albicans, pathogen antibodies, and / or toxins produced by microorganisms. In addition, biosensors can also track and approach or existing Bioactive analytes related to local health issues, such as: stress proteins (such as cytosin) and IL-1 alpha (interleukin 1-alpha) which can be used as a guide for clinical skin irritation or inflammation. In a better specific example, the biosensor has the function of an early warning sensor, which can detect the immediate status of the wearer or caregiver and generate a signal before clinical signs appear. This can provide time to wear People who use preventive drugs or remedial treatment, if they cannot be avoided, they can also significantly reduce the severity and onset of the disease. Moreover, biosensors By detecting the presence of biological target analytes in the body waste of the wearer, the surface can be detected, such as skin and biosensors. 25- This paper size applies to Chinese National Standard (CNS) A4 (210 X 297 mm) I uinn-· n VI It i I order --------- (Please read the precautions on the back before filling out this page) ^ 7 736 A7 B7 V. Description of the invention (23) Reactor Residual pollutants exposed, and provide appropriate signals. (Please read the precautions on the back before filling out this page.) The signal generated by the identification element (s) is transmitted to the wearer or caretaker visually. For example: a color change visible through the human eye. The signal can be qualitative (for example: indicating the presence of a biological target analyte) or quantitative (that is, determining the content or concentration of a biological target analyte). In any. In the example, the signal is preferably durable, that is, stable and readable over a long period of time (typically at least equal to the use time of the object). Furthermore, the sensor can be applied to the concentration of biological target analytes only Above or below preset (Eg: sinking in the presence of biological target analytes in body waste) and / or sending a signal. Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs as described above, the biosensor of the present invention Target analytes suitable for detection are pathogenic microorganisms such as those associated with human gastrointestinal diseases, especially those who cause diarrhea. It has been found that severe chronic diarrhea can cause weight loss and permanent physical and psychological disorders A non-limiting list of pathogenic bacteria that Biosensor 60 can detect includes any of the following pathogenic strains of Escherichia coli (commonly known as E. Coli); Salmonella strains, including S. typhi , S. paratyphi, S. enteriditis, S. typhimurium, and S. heidelberg; Shigella strains, such as: Shigella sonnei, Shigella flexneri, Shigella boydii, and Shigella dysenteriae; Vibrio cholerae; Mycobacterium tuberculosis: Yersinia enterocolitica Aeroraonas hydrophila; Plesiomonas Shigelloides; Campylobacter strain, eg Such as: C. jejuni and C. coli; Bacteroides fragilis; and Clostridia bacteria. Strains, including C. septicum., C, -26- This paper size applies to China National Standard (CNS) A4 (210 X 297 mm): 7 3 咚 A7 __B7 _ V. Description of the invention (24) perfringens, C, botuUnutii, and C 'difficile. A non-limiting example of a commercially available biosensor suitable for the test of E. coli is a test kit # 4001 from AndCare, Inc, of Durham, NC. ABTECH, Scientific, Inc., of Yardley, PA provides "Bioanalytical Biotransformer" with the product number BB Au-1050.5-FD-X "which can be covalently immobilized on its surface, Enzymes, antibodies, or DNA fragments provide biospecificity. Other suitable microbial biosensors are described in US Patent No. 5,869,272 (gram-negative bacteria); 5,795,717 (Shigella); 5,830,341; 5,795,453; 5,354,661; 5,783,399; 5,783,399; 5,827,651; Nos. 5,723,330; and 5,496,700. The target analyte suitable for detection by the biosensor of the present invention may also be a virus. This may include viruses that cause chancretion, such as: rotavirus, or other viruses, such as rhinovirus and human immunity Incomplete virus (HIV). An example of a biosensor suitable for detecting HIV is illustrated in the aforementioned U.S. Patent Nos. 5,830,341 and 5,795,453. Employees' Cooperatives, Intellectual Property Office, Intellectual Property Office, Ministry of Economy (Fill in this page) In another specific example, the target analyte suitable for detection by the biosensor of the present invention may also be Worms, especially those who inhabit the gastrointestinal tract at certain times in their life history. These parasites can include protozoa, worms, and other gastrointestinal parasites. Examples of other parasites that can be detected include Sickness: Amoeba (which causes amoebic dysentery), trypana cruzi (which causes Dengue's disease), and peasmodium falciparum. In other specific examples The target analyte suitable for detection by the biosensor of the present invention is Pseudomonas, such as Candida albicans. In addition, -27- this paper size is applicable to China National Standard (CNS) A4 (210 X 297 mm)
46773B46773B
五、發明說明(25) 經濟部智慧財產局員工消費合作社印製 致病性細菌,#當之有益定殖菌,例如:比菲 (Bmd—ia)及雷特氏菌(Laet〇ba灿叫菌株亦可债測 及/或測定以作爲健康之指標。 本發明(生物感應器適合偵測之目標分析物亦可爲 膚受迫害相Μ之蛋自質或抗體。較佳者,此等分析物爲可 於皮膚表面’較佳爲在臨床可觀察到之皮膚刺激出現前摘 測到者。此可包括壓力蛋白I,例如:胞漿素,组織胺,、 及其他免疫反應因子包括間白素(例如:IL_la,iL_2,iL_ 3,IL-4,及IL-8)及干擾素(包括干擾素a&g)。並且,其 較佳爲於臨床可觀察到之紅腫,刺激,或皮膚炎出現之前 即可被生物感應器60偵測到者。此外,本發明之生物感 應器可適用於偵測與皮膚刺激(例如:尿布疹)有關之^ 素,與其他生物因子,包括胰蛋白酶,胰麋蛋白酶,及脂 解酶。 本發明之生物感應器亦可包含生物辨識系統,包括酵素 或結合性蛋白’例如將抗體固定至物理化學轉化器之表 面。例如特定之細菌菌株可經由含有抗該細.菌菌株之抗 體的生物感應器加以貞測。或者.,目標細菌之偵測可藉由 生物辨識元件(包括抗體及人工或天然分子接受器)專一性. 偵測該目標細菌之胞外產物,例如:菌株(例如:E. c〇li )所 生產之毒素。可用以偵測酚類(例如:尿及糞中)之酵素電 極實例包括:路胺酶基底電極或多酚氧化酶基底電極,其. 説明於美國專利第5,676,820號’,標題爲"Remote Electrochemical Sensor",爲 Jose+ph Wang 等人於 1997 年 1 0 -28 本紙張尺度適用中國國家標準(CNS)A4規格(210 X 297公釐) (請先閲讀背面之注意事項再填寫本頁) i I —--訂---^--- C> 467736 A7 _ B7 五、發明說明(頌) 月14EI公告者及美國專利第5,091,299號,標題為"An Enzyme Electrode For Use In Organic Solvents",為 Anthony P. F· Turner等人於1992年2月2 5曰公告者。 於先前之任一實例中,特定微生物可藉由直接僧測或可 藉由對微生物生產之毒素,酵素或其他蛋白質,或對該微 生物具有專一性之抗體,例如:單株,抗體之結合而偵測 之。適用於偵測蛋白分解性酵素之生物感應器例示於美國 專利第5,607,567號中且適於偵測毒素者例示於美國專利第 5,496,452;5,52U〇l ;及 5;567,301 號中。 本發明之生物感應器可包含一種或多種1’預警感應器,I β 此特別可應用於在臨床可觀察到之健康徵兆出現前,即可 偵測到生物反應性目標分析物之具體實例中·•於此應用中 所使.用之"預警感應器"一辭係指一種感應器,其可侦測 出穿用者之身體上(即:皮膚)或排泄物(即:輸入物)中,與 健康或皮膚相關之即將或潛在發生之事件,直接相關或至 少有相關性之變化或訊號。預警感應器可與一種或多種上 述之輸入物發生反應。 預警感應器可偵測即將出現之事件或偵測出與即將出現 之事件’特別是系統性或皮膚健康狀況或事件(即:臨床可 觀察之指標或徵兆出現)直接相關或至少有相關性之參 數。可藉由本發明之預警感應器加以偵測或預測之即將出 現之病症可包括下痢,皮膚刺激或起疹(包括:念珠菌 病)’及/或其他型式之疾病或穿用者之醫療狀況,例如: 寄生.蟲侵害。所偵測之生物分析物可能距實際臨床徵兆之 -29- 本紙張尺度適用中國國家標準(CNS)A4規格(210 x 297公釐〉 (請先閱讀背面之注意事項再填寫本頁) 裝 訂---------f 經濟部智慧財產局員工消費合作社印製 7 736 A7 B7 五、發明說明(27) 出現尚有一至數個步驟。例如:該生物感應器可偵測上述 情況(例如··皮膚受到糞便污染)中之潛在前驅物,其出現 可在臨床可觀察之皮膚刺激出現前所謗導出之壓力蛋白質 出現之先。與症狀有關係之參數係爲任何可測量之輸入物 或訊號,例如一種或多種上列之潛在輸入物,其與在參考 系統之框架内所發生之事件(即:由排泄物或穿用者產生之 訊號)有關係者。物件中之預警感應器可測量—種或多種 輸入物以便預測事件之發生。例如:預警感應畢可偵測陰 道排出物中之Candida albicans及皮膚上殘留之慢性細菌 (即:價測殘留之污染物),此二者均是可在皮膚刺激之先 出現之訊號。 於生物感應器之具體實例中之生物辨識元件若不產生易 見之訊號(例如:顏色變化),則該生物感應器可包括一種 轉換器與生物辨識元件聯結以.將來自於生物辨識元件之物 理化學訊號轉換成穿用者,看護者,或物件之組件(例如. 及促動器)可利用之訊號。轉換器之示例可包括電化學轉 換器(包括.電位差測定’安培測定,_及電導測定轉換 器)’光學轉換器(包括:螢光’生物發光,總内部反射共 振’及表面胞漿共振),熱轉換器及聲波轉換器,如同此 技藝中所熟知者。電源例如:小型之3伏特錶電池或印刷薄 膜叙電池可連接於生物感應器上以提供任何所需之動能。 實例 一個實例係爲具有血液偵測器且可對不同之婦女提供生 理期接近之指示的褲墊》該褲骜係爲傳統褲墊,其具有一 -30- 本紙張尺度過用中國國家標準(CNS)A4現格(210 X 297公爱) (請先閲讀背面之注意事項再填寫本頁) —裝 mmmmm H ί 1· ^ I n n i I ϋ —Jv J t广'/ 經濟部智慧財產局員工消費合作社印製 4 6 7 73^ A7 _B7_五、發明說明(28) 頂層,一第二頂層介於頂層及核心之間,一核心層及聚乙 二烯膜底層。 血液指示劑含有二種成份,第一種成份爲以0.2克乙二 醇·作爲載體且以0.04克之epta- g太醯亞胺-過氧己酸爲作用 於表面張力之成份的組合物。第二種成份爲以0.2克乙二 醇作爲載體且以0.02克之癒創膠爲作用於表面張力之成份 的組合物。第一種成份以寬20毫米及長130毫米之長條形 塗佈於第二頂層之朝衣物表面上。第二種成份以寬20毫 米及長130毫米之長條形塗佈於吸收核心之朝衣物表面 上。 或者,將商業化可得之長條狀血液偵測器如同上述範例 插入褲墊之頂層及底層間亦具有可接受之結果。此等長條 可購自於例如:Menarini Company,Florence Italy,之 Chroma 6™ KDK Corporation of Kyoto,Japan 之 Arkray Aution Sticks™。於另一替代品中,可以與長條狀血液偵 測器相同之方式使用長條狀pH指示劑,其亦具有可接受 之結果。此等長條狀p Η指示劑可購自上述之Merck公司, 其產品名爲 Spezial Indikator,code 109542。 (請先閲讀背面之沒意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 -31 - 本紙張尺度適用令國國家標準(CNS)A4規格(210 χ 297公釐)V. Description of the invention (25) The pathogenic bacteria printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs, # are beneficial colonizing bacteria, such as: Bmd-ia and Laetoba Strains can also be tested and / or tested as indicators of health. The target analytes suitable for detection by the biosensor of the present invention can also be the egg quality or antibodies of the persecuted phase M. Preferably, such analysis The substance is available on the skin's surface, preferably it is taken before the clinically observable skin irritation occurs. This may include stress proteins I, such as cytosin, histamine, and other immune response factors including interstitial Interleukins (eg, IL_la, iL_2, iL_3, IL-4, and IL-8) and interferons (including interferon a & g). Moreover, it is preferably redness, swelling, irritation, or Dermatitis can be detected by the biosensor 60 before the appearance of dermatitis. In addition, the biosensor of the present invention can be applied to detect hormones related to skin irritation (such as diaper rash), and other biological factors, including pancreas Proteases, trypsin, and lipolytic enzymes. The sensor may also include a biometric system, including enzymes or binding proteins, such as immobilizing antibodies to the surface of a physico-chemical converter. For example, a specific bacterial strain may be chased through a biosensor containing antibodies against the strain. Or, the detection of target bacteria can be specific through the use of biorecognition elements (including antibodies and artificial or natural molecular receptors) to detect the extracellular products of the target bacteria, such as strains (eg E. c. li) toxin produced. Examples of enzyme electrodes that can be used to detect phenols (eg, urine and feces) include: Luminase substrate electrodes or polyphenol oxidase substrate electrodes, which are described in US Patent No. 5,676,820 ' , Titled " Remote Electrochemical Sensor ", by Jose + ph Wang et al., 1 0 -28, 1997 This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) (Please read the note on the back first Please fill in this page for more information) i I --- Order --- ^ --- C > 467736 A7 _ B7 V. Description of the Invention (Song) 14EI Announcer and US Patent No. 5,091,299, titled " A n Enzyme Electrode For Use In Organic Solvents " was announced by Anthony P. F. Turner et al. on February 25, 1992. In any of the previous examples, specific microorganisms can be tested directly or by Detects toxins, enzymes or other proteins produced by microorganisms, or antibodies specific to the microorganism, such as individual strains and the detection of antibody binding. Biosensors suitable for detecting proteolytic enzymes are exemplified in U.S. Patent No. 5,607,567 and those suitable for detecting toxins are exemplified in U.S. Patent Nos. 5,496,452; 5,52U0l; and 5; 567,301. The biosensor of the present invention may include one or more types of 1 'early warning sensors. I β is particularly applicable to specific examples in which bioreactive target analytes can be detected before clinically observable health signs appear. · • Used in this application. The term "warning sensor" refers to a sensor that can detect the wearer's body (ie, skin) or excrement (ie, input). ), An upcoming or potential event related to health or skin that is directly related or at least related to a change or signal. The warning sensor can react with one or more of the inputs mentioned above. The early warning sensor can detect an upcoming event or detect a direct or at least related to an upcoming event ', especially a systemic or skin health condition or event (ie, a clinically observable indicator or sign appears). parameter. Imminent conditions that can be detected or predicted by the early warning sensor of the present invention may include chancre, skin irritation or rash (including: candidiasis) 'and / or other types of diseases or the medical condition of the wearer, For example: Parasite. Insect infestation. The detected biological analytes may be -29 away from the actual clinical signs. This paper size is applicable to the Chinese National Standard (CNS) A4 specification (210 x 297 mm) (Please read the precautions on the back before filling this page) Binding- -------- f Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 7 736 A7 B7 V. Description of the invention (27) There are still one or more steps. For example: the biosensor can detect the above situation ( For example, the potential precursors in skin contaminated by feces) can appear before the appearance of stress proteins derived from clinically observable skin irritation. The parameters related to symptoms are any measurable inputs Or signals, such as one or more of the potential inputs listed above, that are related to events that occur within the framework of the reference system (ie, signals generated by feces or the wearer). Early warning sensors in objects Measurable-one or more inputs to predict the occurrence of an event. For example, early detection can detect Candida albicans in vaginal discharge and chronic bacteria remaining on the skin Pollutants), both of which are signals that can appear before skin irritation. If a biometric element in a specific example of a biosensor does not produce a visible signal (eg, a color change), the biosensor It may include a converter connected to the biometric element to convert the physicochemical signal from the biometric element into a signal that can be used by a wearer, caregiver, or a component of an object (such as an actuator). Examples can include electrochemical converters (including potentiometric measurements, amperometric, and conductance converters), optical converters (including: fluorescent 'bioluminescence, total internal reflection resonance', and surface plasmon resonance), thermal Converters and sonic converters are well known in the art. Power sources such as small 3 volt battery or printed film batteries can be connected to the biosensor to provide any required kinetic energy. Examples An example is to have Blood pant and pant pad that can provide different women with indications of physiological period approach "The pant is a traditional pant pad with a -30- Paper size used Chinese National Standard (CNS) A4 now (210 X 297 public love) (Please read the precautions on the back before filling this page) — mmmmm H ί 1 · ^ I nni I ϋ — Jv J t 广'/ Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs 4 6 7 73 ^ A7 _B7_ V. Description of the invention (28) The top layer, a second top layer is between the top layer and the core, a core layer and a polyethylene film Bottom layer. The blood indicator contains two components. The first component is a composition that uses 0.2 g of ethylene glycol as a carrier and 0.04 g of epta-g-toluidine-peroxyhexanoic acid as a component acting on surface tension. The second component is a composition containing 0.2 g of ethylene glycol as a carrier and 0.02 g of guaiac as a component acting on surface tension. The first component is applied in a strip shape with a width of 20 mm and a length of 130 mm on the garment facing surface of the second top layer. The second component is applied to the garment-facing surface of the absorbent core in a strip shape having a width of 20 mm and a length of 130 mm. Alternatively, inserting a commercially available strip-shaped blood detector as in the example above and inserting it between the top and bottom layers of the panty pad will have acceptable results. These strips are available from, for example, Menarini Company, Florence Italy, Chroma 6 ™ KDK Corporation of Kyoto, Japan Arkray Aution Sticks ™. In another alternative, a strip-shaped pH indicator can be used in the same way as a strip-shaped blood detector, which also has acceptable results. These long strip p (R) indicators are available from the aforementioned Merck company under the product name Spezial Indikator, code 109542. (Please read the unintentional matter on the back before filling out this page) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs -31-This paper size applies the national standard (CNS) A4 specification (210 χ 297 mm)
Claims (1)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2000/011204 WO2000065083A2 (en) | 1999-04-26 | 2000-04-26 | Feminine sanitary disposable article having a blood detection means as sensor |
Publications (1)
Publication Number | Publication Date |
---|---|
TW467736B true TW467736B (en) | 2001-12-11 |
Family
ID=21741317
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW089114350A TW467736B (en) | 2000-04-26 | 2000-07-18 | Feminine sanitary disposable article having a blood detection means as sensor |
Country Status (1)
Country | Link |
---|---|
TW (1) | TW467736B (en) |
-
2000
- 2000-07-18 TW TW089114350A patent/TW467736B/en active
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1173618A1 (en) | Panty liner with sensor for predicting the start of menstruation | |
US6479727B1 (en) | Diagnostic panel | |
US6436055B1 (en) | Device having diarrhea diagnostic panel | |
US7982088B2 (en) | Disposable article having a biosensor | |
US20130296739A1 (en) | Diaper with Pocket for an Absorbent Pad Containing a Test Strip | |
CZ20004751A3 (en) | Disposable article having bodily waste component sensor | |
AU2008337169A1 (en) | Urine volume hydration test devices | |
WO2000000822A1 (en) | Device having fecal component sensor | |
TW467736B (en) | Feminine sanitary disposable article having a blood detection means as sensor | |
EP1092151B2 (en) | Device having fecal component sensor | |
KR20020000877A (en) | Feminine sanitary disposable article having a blood detection means as sensor | |
TW476640B (en) | Disposable article, article for detecting the presence of vaginal infections, and absorbent interlabial device | |
EP1091773B1 (en) | Disposable article having bodily waste component sensor | |
GB2578901A (en) | Bioscreen |