4408 79 A7 -----B7 五、發明說明（/ ) 1·發明之領域 本發明是一種適用於迴旋加速器液體照射靶系統之 液體傳送裝置。利用本裝置將液體傳送至靶腔中，以迴 旋加速器產生之高速粒子撞擊輸入之液體，待核子反應 完成後，再將產生之放射性同位素與液體，傳至鉛室中 進行化學分離。 2 ·發明之背景 迴旋加速器的主要功能之一在生產放射性同位素。 為達到此一目的，必須要有各式各樣的靶體配合，如固 體乾' 氣體乾、液體靶等，才能有效順利地生產各種不 同的放射性同位素。液體靶為生產如F_18同位素放射性 所必需的一種方法’由於近年來核醫藥物應用極為普遍 ，紐半衰期的F-18同位素需求曰益增加。以迴旋加速器 生產放射性同位素的原理為：利用被電場及磁場加速後 的高速粒子撞擊適當的靶物質，經核反應後產生放射性 同位素，再經化學分離純化處理，即可產生所需之放射 性同位素。液體或氣體靶物質，因受制於其物理特性， 無法完整的受粒子撞擊照射，故必須裝置在容器中。一 般裝填液體的方式皆由工作人員手持注射針筒，在液體 儲存瓶中抽取定量的液體後，進入照射靶室，開啟靶腔 液體注入閥及排氣閥，將液體注入乾腔内，再關閉注入 閥及排氣閥’隨後打開加壓閥將靶腔加壓至所需之壓力 母-入照射Θ皆需重覆做此相同之工作，除所注入的液 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閲讀背面之注意事項再填寫本頁) 裝 ----訂i I I I I ---線 經濟部智慧財產局員工消費合作社印製 經濟部智慧財產局員工消f合作社印製 44 08 7 9 A7 _____________B7______ 五、發明說明（2 ) 體量不易控制’亦可能造成人為的疏失而前功盡棄外， 且此項工作需要在輻射極高的靶室内進行，操作人員常 會受到較高的輻射劑量，為維護工作人員安全，宜儘量 減少進入靶室之次數與時間β基於上述理由，為準確且 可靠的將固定量的液體注入靶腔中，且減少工作人員的 輻射曝露劑量’保證照射產品的可靠和一致性，維護工 作人員之安全’將原本由人工操作的方式改為利用電腦 控制的全自動方法，將液體自動注入靶腔内，經射束照 射後’亦能自動的將靶腔内的液體及所產生之放射性同 位素自靶腔傳送至鉛室中，進行後續化學處理，遂有本 發明之液體靶傳送裝置之開發。 3 -發明之目的 本發明之目的在提出一種迴旋加速器液體靶傳送裝 置，使用上安全可靠及操作簡單。 本發明之另一目的，在提供一種液體的傳送裝置， 可定量地連續地傳送液體至所需之處。 本發明之再一目的，在提供一種液體的傳送裝置， 人員在耙室外操作即可將固定量液體傳送至靶室内的靶 腔中，不致造成工作人員之輻射傷害。 本發明之又一目的，再提供一種液體之傳送裝置， 構造簡單且造價低廉，可完全由本國製造。 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公爱） (請先閱讀背面之沒意事項再填寫本頁) 裝---- 訂i I-----*線 ！ 經濟部智慧財產局貝工消费合作社印製 4 4 08 79 A7 ____B7__ 五、發明說明（3 ) 圖式之簡單說明 圖1.為氧-18水注入系統方塊圖 圖2,為氧-18液體靶傳送系統之流程圖。 圖號名稱說明 He 氦氣 1 壓力調節器 11 高壓調節器 12 低壓調節器 2 玻璃瓶 VI-V6電動閥4408 79 A7 ----- B7 V. Description of the invention (/) 1. Field of the invention The present invention is a liquid transfer device suitable for a cyclotron liquid irradiation target system. The device is used to transfer the liquid to the target cavity. The high-speed particles generated by the cyclotron impact the input liquid. After the nuclear reaction is completed, the generated radioisotopes and liquid are transferred to the lead chamber for chemical separation. 2. Background of the invention One of the main functions of cyclotrons is the production of radioisotopes. In order to achieve this goal, it is necessary to have a variety of target bodies, such as solid dry, gas dry, and liquid targets, in order to effectively and smoothly produce a variety of different radioisotopes. A liquid target is a method necessary for the production of radioactive isotopes such as F_18. Due to the widespread use of nuclear medicines in recent years, the demand for F-18 isotopes in the new half-life has increased. The principle of using a cyclotron to produce radioisotopes is to use high-speed particles accelerated by an electric and magnetic field to strike an appropriate target substance, generate a radioisotope after a nuclear reaction, and then chemically separate and purify it to produce the required radioisotope. Liquid or gas target materials cannot be completely exposed to the impact of particles due to their physical characteristics, so they must be installed in a container. Generally, the way of filling the liquid is by the staff holding an injection syringe. After extracting a fixed amount of liquid from the liquid storage bottle, it enters the irradiation target chamber, opens the target cavity liquid injection valve and exhaust valve, injects the liquid into the dry cavity, and then closes. The injection valve and exhaust valve 'are then opened to pressurize the target cavity to pressurize the target cavity to the required pressure-the irradiation Θ needs to be repeated to do the same work, except that the paper size of the injected liquid applies Chinese national standards ( CNS) A4 specification (210 X 297 mm) (Please read the precautions on the back before filling this page) Binding-order i IIII --- Intellectual Property Bureau of the Ministry of Economic Affairs Employee Consumption Co-operative Printing Intellectual Property of the Ministry of Economic Affairs Printed by the staff of the Bureau, printed by the cooperative 44 08 7 9 A7 _____________B7______ V. Description of the invention (2) The mass is not easy to control, it may also cause human error and the previous work is completely abandoned, and this work needs to be carried out in a target room with high radiation. Personnel often receive high radiation doses. To maintain the safety of workers, it is advisable to minimize the number and time of entering the target chamber. Based on the above reasons, a fixed amount of The body is injected into the target cavity, and the radiation exposure dose of the workers is reduced. 'The reliability and consistency of the irradiated products are maintained, and the safety of the workers is maintained.' The original manual operation was changed to a computer-controlled full-automatic method to automatically change the liquid automatically. After being injected into the target cavity, after being irradiated with the beam, the liquid in the target cavity and the radioactive isotope generated can be automatically transferred from the target cavity to the lead chamber for subsequent chemical processing, and then the liquid target delivery device of the present invention is provided. Development. 3-Object of the invention The object of the present invention is to propose a cyclotron liquid target transfer device, which is safe and reliable in use and simple in operation. Another object of the present invention is to provide a liquid transfer device capable of continuously and quantitatively transferring liquid to a desired place. Yet another object of the present invention is to provide a liquid transfer device, which allows a person to transfer a fixed amount of liquid into a target cavity in a target chamber by operating outside the rake, without causing radiation damage to workers. Yet another object of the present invention is to provide a liquid transfer device, which has a simple structure and low cost, and can be completely manufactured in the country. This paper size applies to Chinese National Standard (CNS) A4 specifications (210 X 297 public love) (Please read the unintentional matter on the back before filling this page). ---- Order i I ----- * line! Printed by the Shelley Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs 4 4 08 79 A7 ____B7__ V. Description of the invention (3) Simple illustration of the diagram Figure 1. Block diagram of the oxygen-18 water injection system Figure 2. The oxygen-18 liquid target Flow chart of the delivery system. Description of drawing number name He Helium 1 Pressure regulator 11 High pressure regulator 12 Low pressure regulator 2 Glass bottle VI-V6 electric valve
Vt 注入器 4 靶腔 5 溢流瓶 6 微孔過濾臈 7 閥門控制器 8 計時器 兹依照圊1 ' 2就本發明一種迴旋加速器液體照射 靶系統之液體傳送裝置敘述如下。 本傳送裝置係由鐵氟龍細管、電動閥VI —V6、注入 器Vt、氦氣He與氦氣瓶、壓力調節器1 、玻璃瓶（氧― 18水儲存瓶）2、靶腔4、溢流瓶5 、微孔過濾膜6、 閥門控制器7和計時器8等組成，詳細規格與操作說明 如下： 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先Μ讀背面之注意事項再填寫本頁) 裝-------訂·--------線 經濟部智慧財產局員工消费合作社印製 4 4 08 7 9 A7 ____B7 五、發明說明（4* ) (1) 鐵氟龍細管：外徑為1/16吋，内徑為〇 8隱。儲 存瓶2至靶腔4 ，至溢流瓶5，靶腔4至鉛室間的管路 皆以鐵氟龍細管裝配。 (2) 氦氣與氦氣瓶：氦氣He的純度為99 99%，儲存 於氦氣瓶中，是傳送液體至靶腔4及將照射後的液體傳 送至鉛室的動力。 (3) 壓力調節器i :為調節氦氣輸出壓力，壓力範圍 為 0〜300psi。 (4) 玻璃瓶2 :體積1〇〜50ml的無菌瓶，上有鋁蓋 與橡皮隔膜，玻璃瓶2用於儲存液體靶及接收溢流液。 液體加入玻璃瓶2中係以無菌針筒裝上無菌針頭，由橡 皮隔膜穿入，將液體打入玻璃瓶2中，以避免污染。 (5) 電動閥VI — V6:可受控制的電動閥，必須可以忍 欠20Opsi以上的電動閥，才能有效的控制。電動閥主要 功能在控制液體的傳送與流向。 (6) 壓縮空氣：針對使用裝置為氣動式電動閥，即需 要使用壓縮空氣。 (7)閥門控制器7 :電動閥VI —V6之開關由閥門控 制器7來控制。本控制器由變壓器與開關組成，將丨i 〇 伏特之電壓轉變成24伏特電壓，以此來控制電動閥，本 控制器可以用手動操作也可以用電腦作全自動操作。 (8)計時器8 :計時器8與閥門控制器7的配合，可 以控制閥門開關的時間長短，本計時器8必須可以控制 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ----mi----- ^---II---^-1------- {锖先閱讀背面之沒意事項再填寫本頁) 4408 79 A7 --B7 五、發明說明（孓） 至十分之一秒以下。 (9)微孔過濾膜6 :孔徑為〇, 22mm的過濾膜，主要 目的為通氣，除能液體順利流入乾腔4中，亦可避免細 菌塵埃等進入液體中。 本裝置由以上物件組合而成的液體傳送裝置，其概 念設計如附圖1 ，組合配置如附圖2 ，能達到液體順利 傳送的目的。 本發明裝置之組合構造詳如上述及附圖1、2，茲就 使用方法說明如下： (1) 首先以無菌針筒抽取1〇 一 5〇ml液體，針頭穿過 液體玻璃瓶2的橡膠隔膜，將液體注入玻璃瓶 2中，玻璃瓶2上插有兩條細管，氦氣供應的 細管必須保持在液面上，另一條細管管口必須 面貼玻璃瓶底，才能使儲存的液體做多次使用 。液體由玻璃瓶2傳送至靶腔4時必須先依照 如下操作： (2) 打開氦氣瓶，檢查氦氣的壓力為大於10大氣壓 。（如果小於10 atm必須更換之） (3) 調整高壓壓力調節器11，使氦氣經過高壓調節 器11的壓力為60psi或適當壓力。 (4) 調整低壓壓力調節器12，使氦氣進入玻璃瓶2 中的壓力只有7psi或適當壓力。 (5) 溢流瓶5上插有來自乾腔4來的細管，另以針 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先A3讀背面之注意事項再填寫本I) 裝 訂--------- 經濟部智慧財產局員工消費合作社印製 經濟部智慧財產局員工消費合作社印製 4 4 08 79 a? _____ _ ____ B7 五、發明說明（6 ) 頭連接微孔過瀘、膜6插在瓶蓋上，以不接觸到 液體為原則，做為通氣用。 (6)注入器Vt是控制液體注入量最重要的一個閥門 受閥門控制器7和計時器8的控制。此間一 打開，液體即由玻璃瓶2中受7psi的氦氣壓力 ，流至靶腔4中。液體注入量的受制於注入器 Vt開關時間的長短與氦氣的壓力。如果氦氣壓 力為7psi ’則三秒鐘可以傳送12 液體至乾 腔4中。為避免傳送的液體量不足，通常以乾 腔4充滿後有點溢出為原則，溢出的液體流至 溢流瓶5 ，可以再回收使用。 液體傳送至靶腔4的操作流程說明如下： (1) 打開氦氣瓶’氦氣He經高壓力調節器11的壓力 調整為60psi，經V3及低壓調節器12，至液體 玻璃瓶2的壓力有7psi。 (2) 打開VI使氦氣流向至V2，開V4，開V5使流向至 別’開V6至溢滿瓶5 。 (3) 打開Vt’液體開始流至靶腔4 ，充滿靶腔4 ， 且有一點點滴進入溢流瓶5 ，關Vt。在7psi 的氦氣壓力條件下，Vt打開的時間約3秒鐘， 即可達到充滿耙腔4之液體為1. 2mL，調整Vt 打開時間可改變水量〇. ImL至10mL所需的範圍 内’以0. 5mL至5 mL最佳。 本紙張尺度適用中國國家標準（CNS)A4規格（210 * 297公釐） 丨丨！ if丨f丨丨— _ 裝-----1訂·---！！·竣 (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局具工消費合作社印製 440879 A7 _______B7_______ 五、發明說明（7 ) (4)關 V2，V4，V6， 完成以上步驟時，靶腔4確已充滿液體，可以開始 照射。照射結束後再將產生之放射性同位素與液體傳送 至錯室。傳送流程如下： 1_開vi至鉛室的方向 2. 開V3至V5的方向 3. 開V5至乾腔的方向 4. 開 V4 ， V2 氦氣以60psi的壓力，將照射過的液體傳送至鉛室 中。耙腔至鉛室之距離約40公尺，1分鐘内可以傳送完 成。 以上的裝置可以只用閥門控制器7 ，用手動方式來 操作’也可以用電腦控制閥門’以全自動方式來操作。 本發明液體靶傳送裝置，以適用於迴旋加速器液體靶照 射系統之液體傳送為主要應用’但不排除其他液體乾傳 送之應用，在此附帶聲明。 茲就本發明裝置之實驗說明如下： 實施例1:液體傳送準確度之試驗 利用前述操作步驟將20ml的蒸餾水注入儲 存瓶2中’以下述之條件進行測試： 氛氣的南壓没疋為6 Ops i，（2)氦氣的低塵 設定為7psi ; (3)Vt打開後再關閉的時間 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閲讀背面之注意事項再填寫本頁) 裝------- 訂-------— •埃 A7 B7 ^4 08-7 9 五、發明說明（？） 為三秒鐘。蒸餾水輸送情形，其結果如 表一，顯示液體自靶腔傳送自鉛室儲存瓶 的時間為45± 2秒，液體收集重量平均誤 差 < 1 %。 表一、液體傳送試驗 次數 溢流量 傳送至鉛室的時間 至鉛室液體收集的 重量+ 1 0. 05木 48秒 1. 15g 2 0. 10g 45秒 1. 16g 3 〇. l〇g 44秒 1. 15g 4 〇. llg 43秒 1. 17g 5 0. l〇g 45秒 1. 16g 6 0. llg 50秒 1. 14g 7 0. lOg 43秒 1. 17g 8 0. 12g 45秒 1. 14g 9 0. llg 47秒 1, 13g 10 0. lOg 48秒 1. 15g 11 0. log 44秒 1. 16g 12 0. 12g 45秒 1. 14g 13 0. llg 42秒 1. 15g 14 o. log 44秒 1. 14g 15 0. llg 49秒 1. 16g 平均 平均 平均 0. 11+ 0. 01 45± 2 秒 1.15+ 0.Olg 本紙張尺度適用中國國家標準（CNS)A4規格（210 χ 297公釐） (請先M讀背面之注意事項再填寫本頁) ^4 — 11丨—訂---------錄 經濟部智慧財產局員Η消費合作杜印製 4408 7 9 A7 —---sz_. 五、發明說明（7) *(1)液體第一次傳送時，傳送細管是乾的，溢流 量較少’故不將這次的值0,05g計入平均值。 (2)靶腔的容量決定液體傳送至鉛室收集的重量。 實施例2:利用本液體傳送裝置傳送氧_16水研製氮-13放射性同位素 以本液體傳送裝置將蒸溜水注入乾腔 中’在迴旋加速器質子束17Mev ， 10uA，照射10分鐘，傳送照射液至鉛室 中，取樣分析。經放射性同位素核種分 析儀（Multichannel Analyzer，MCA)連接 高純度鍺偵檢器測量，顯示加馬能譜為 單一的511Kev能峰，並測得半衰期為 10分鐘，確定為氮-13放射性同位素， 顯示該同位素係自16〇(ρ’ α)核反應產 生’再以活度量測儀（Capintech)測量氮-13之總活度為15mCi。 經濟部智慧財產局具工消费合作社印製 (請先Μ讀背面之注意事項再填寫本頁) 實施例3:利用本裝置傳送氧-18水研製氟-18放射性同位素 將豐度>95%的氧-18水，以本液體傳送 裝置注入腔靶中，在迴旋加速器質子束 17Mev，20uA，照射60分鐘，傳送照射 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 經濟部智慧財產局員工消費合作社印製 440879 A7---_ 五、發明說明（丨〇 ) 液至錯室中，取樣分析。經放射性同位 素核種分析儀連接高純度鍺偵檢器測 量’顯示加馬能譜為單一的5111(^波 峰，並測得半衰期為110分鐘，確定為 氟-18放射性同位素，顯示該同位素係自 0 (P，η)核反應產生，其成品規格符合 美國藥典要求（半衰期在105〜115分鐘之 間）’再以活度量測儀測量其氟_18之總活 度為 824mCi»Vt injector 4 target chamber 5 overflow bottle 6 microporous filter 7 valve controller 8 timer The liquid transfer device of a cyclotron liquid irradiation target system according to the present invention is described below in accordance with 1'2. The transmission device consists of Teflon thin tube, electric valve VI-V6, injector Vt, helium He and helium cylinder, pressure regulator 1, glass bottle (oxygen-18 water storage bottle) 2, target cavity 4, overflow Flow bottle 5, microporous membrane 6, valve controller 7, timer 8 and other components, detailed specifications and operating instructions are as follows: This paper size applies to China National Standard (CNS) A4 specifications (210 X 297 mm) (please first (Please read the precautions on the back and fill in this page again.) Packing ------- Ordering · -------- Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs 4 4 08 7 9 A7 ____B7 V. Invention Explanation (4 *) (1) Teflon thin tube: outer diameter is 1/16 inch, inner diameter is 0. The pipes from storage bottle 2 to target cavity 4 to overflow bottle 5 are all assembled with Teflon thin tubes. (2) Helium and helium cylinders: The purity of helium He is 99 99%, which is stored in helium cylinders, which is the power to transfer liquid to the target cavity 4 and the irradiated liquid to the lead chamber. (3) Pressure regulator i: To adjust the output pressure of helium, the pressure range is 0 ~ 300psi. (4) Glass bottle 2: a sterile bottle with a volume of 10-50ml, with an aluminum cap and a rubber septum. Glass bottle 2 is used to store the liquid target and receive the overflow liquid. The liquid is added to the glass bottle 2 with a sterile needle mounted on a sterile needle, penetrated by a rubber septum, and the liquid is poured into the glass bottle 2 to avoid contamination. (5) Electric valve VI — V6: The controllable electric valve must be able to endure more than 20Opsi electric valve for effective control. The main function of the electric valve is to control the transfer and flow of liquid. (6) Compressed air: For the device used is a pneumatic electric valve, compressed air is required. (7) Valve controller 7: The switches of electric valve VI-V6 are controlled by valve controller 7. The controller consists of a transformer and a switch, which converts the voltage of 丨 〇 volts to 24 volts to control the electric valve. The controller can be operated manually or with a computer for full automatic operation. (8) Timer 8: The cooperation of timer 8 and valve controller 7 can control the length of time for valve opening and closing. The timer 8 must be able to control the paper size. Applicable to China National Standard (CNS) A4 (210 X 297 mm) (Li) ---- mi ----- ^ --- II --- ^-1 --------- (锖 Read the unintentional matters on the back before filling in this page) 4408 79 A7 --B7 5. Description of the invention (i) to less than one tenth of a second. (9) Microporous filter membrane 6: A filter membrane with a pore size of 0,22 mm. The main purpose is to ventilate, the energy-eliminating liquid can flow into the dry cavity 4 smoothly, and bacteria and dust can also be prevented from entering the liquid. This device is a liquid transfer device composed of the above objects. Its conceptual design is shown in Figure 1 and its combined configuration is shown in Figure 2 to achieve the purpose of smooth liquid transfer. The combined structure of the device of the present invention is as detailed above and attached to Figures 1 and 2, and the method of use is described as follows: (1) First, a 150 ml liquid is drawn through a sterile syringe, and the needle passes through the rubber septum of the liquid glass bottle 2. Inject the liquid into the glass bottle 2. Two thin tubes are inserted into the glass bottle 2. The thin tube for helium supply must be kept on the liquid surface, and the mouth of the other thin tube must face the bottom of the glass bottle to make the stored liquid long. Times of use. When the liquid is transferred from the glass bottle 2 to the target cavity 4, the following operations must be performed first: (2) Open the helium cylinder and check that the pressure of the helium gas is greater than 10 atmospheres. (If it is less than 10 atm, it must be replaced.) (3) Adjust the high pressure regulator 11 so that the pressure of helium gas passing through the high pressure regulator 11 is 60 psi or an appropriate pressure. (4) Adjust the low-pressure pressure regulator 12 so that the pressure of helium gas entering the glass bottle 2 is only 7 psi or an appropriate pressure. (5) The overflow bottle 5 is inserted with a thin tube from the dry cavity 4, and the paper size of the needle applies the Chinese National Standard (CNS) A4 specification (210 X 297 mm) (Please read the precautions on the back of A3 before Complete this I) Binding --------- Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs Printed by the Consumer Cooperatives of the Ministry of Economic Affairs Intellectual Property Bureau Printed by 4 4 08 79 a? _____ _ ____ B7 V. Invention Description ) The head is connected to the micro hole and the membrane 6 is inserted into the bottle cap. The principle is not to contact the liquid for ventilation. (6) The injector Vt is the most important valve for controlling the amount of liquid injected. It is controlled by the valve controller 7 and the timer 8. As soon as this is opened, the liquid flows from the glass bottle 2 to the target cavity 4 under a pressure of 7 psi of helium. The amount of liquid injected is limited by the length of the Vt switch time of the injector and the pressure of helium. If the helium pressure is 7 psi, 12 liquids can be transferred to the dry chamber 4 in three seconds. In order to avoid the insufficient amount of liquid to be transferred, the principle is that the dry cavity 4 is full after it is full. The overflowed liquid flows to the overflow bottle 5 and can be recycled. The operation flow of the liquid to the target cavity 4 is described as follows: (1) Open the helium cylinder 'helium He is adjusted to 60psi by the high pressure regulator 11 and the pressure to the liquid glass bottle 2 via the V3 and the low pressure regulator 12 There is 7psi. (2) Open VI to make the helium gas flow to V2, open V4, and open V5 to flow to other's, open V6 to overflow bottle 5. (3) Open the Vt 'liquid and begin to flow to the target cavity 4, fill the target cavity 4, and a little bit into the overflow bottle 5, and close Vt. Under the condition of 7psi helium pressure, the time of Vt opening is about 3 seconds, and the liquid filled with rake chamber 4 can reach 1.2 mL. Adjusting the Vt opening time can change the amount of water within the required range of 0.1mL to 10mL ' The best is 0.5mL to 5mL. This paper size applies to China National Standard (CNS) A4 (210 * 297 mm) 丨 丨! if 丨 f 丨 丨 — _ equipment ----- 1 order ----! !! · Complete (please read the notes on the back before filling this page) Printed by the Industrial Property Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs 440879 A7 _______B7_______ V. Description of the invention (7) (4) Off V2, V4, V6, when completing the above steps The target cavity 4 is indeed filled with liquid and can be irradiated. After the irradiation is completed, the radioisotope and liquid generated are transferred to the wrong chamber. The transfer process is as follows: 1_Open vi to the lead chamber 2. Open V3 to V5 3. Open V5 to the dry chamber 4. Open V4 and V2 Helium at 60 psi to deliver the irradiated liquid to Lead room. The distance from the harrow cavity to the lead chamber is about 40 meters, which can be transferred within 1 minute. The above device can be operated by using only the valve controller 7 manually, or by using a computer to control the valve, in a fully automatic manner. The liquid target transfer device of the present invention uses liquid transfer suitable for a cyclotron liquid target irradiation system as a main application 'but does not exclude other applications for dry transfer of liquids, and hereby attaches a statement. The experiment of the device of the present invention is described as follows: Example 1: Test of the accuracy of liquid transfer Using the above-mentioned operation steps, 20 ml of distilled water is poured into the storage bottle 2 'for testing under the following conditions: The south pressure of the atmosphere is 6 Ops i, (2) The low dust setting of helium is 7psi; (3) The time after Vt is turned on and then off This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) (Please read the back Please fill in this page again for attention) Installation ------- Order --------- • A7 B7 ^ 4 08-7 9 V. The description of the invention (?) Is three seconds. Distilled water is transported. The results are shown in Table 1. It shows that the time for the liquid to be transferred from the target cavity to the lead storage bottle is 45 ± 2 seconds, and the average error of the collected liquid weight is <1%. Table 1. Number of liquid transfer tests. The time from the overflow flow to the lead chamber to the weight of liquid collected in the lead chamber + 1.05 wood 48 seconds 1.15g 2 0. 10g 45 seconds 1. 16g 3 0.14 g 44 seconds 1.15g 4 llg 43 seconds 1.17g 5 0. l0g 45 seconds 1.16g 6 0.llg 50 seconds 1.14g 7 0.10g 43 seconds 1.17g 8 0. 12g 45 seconds 1.14g 9 0. llg 47 seconds 1, 13g 10 0. lOg 48 seconds 1. 15g 11 0. log 44 seconds 1. 16g 12 0. 12g 45 seconds 1. 14g 13 0. llg 42 seconds 1. 15g 14 o. Log 44 Seconds 1.14g 15 0.llg 49 seconds 1.16g average average average 0.11+ 0. 01 45 ± 2 seconds 1.15+ 0.Olg This paper size applies the Chinese National Standard (CNS) A4 specification (210 χ 297 mm) ) (Please read the notes on the back before filling in this page) ^ 4 — 11 丨 —Order --------- Recorded by the Intellectual Property Bureau of the Ministry of Economic Affairs and Consumer Cooperation Du printed 4408 7 9 A7 —-- -sz_. V. Description of the invention (7) * (1) The first time the liquid is transferred, the transfer tube is dry and the overflow is low. Therefore, the value of 0,05g is not included in the average value. (2) The volume of the target cavity determines the weight of the liquid transferred to the lead chamber to collect. Example 2: Use this liquid transfer device to transfer oxygen_16 water to develop nitrogen-13 radioisotopes. Use this liquid transfer device to inject distilled water into the dry cavity. 'In a cyclotron proton beam 17 MeV, 10 uA, irradiate for 10 minutes, and transfer the irradiation liquid to Sampling and analysis in lead room. Measured by a multichannel analyzer (MCA) connected to a high-purity germanium detector, the Gama energy spectrum is a single 511Kev energy peak, and the measured half-life is 10 minutes. It is determined to be a nitrogen-13 radioisotope. This isotope was generated from a nuclear reaction of 160 (ρ'α), and the total activity of nitrogen-13 measured by a vimeometer (Capintech) was 15 mCi. Printed by the Intellectual Property Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs (please read the precautions on the back before filling this page). Example 3: Use this device to transfer oxygen-18 water to develop fluorine-18 radioisotopes. The abundance will be> 95%. The oxygen-18 water was injected into the cavity target with the liquid delivery device, and the cyclotron proton beam was 17Mev, 20uA, and irradiated for 60 minutes. The transmission and irradiation of this paper were in accordance with Chinese National Standard (CNS) A4 (210 X 297 mm). Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 440879 A7 ---_ V. Description of the invention (丨 〇) The liquid was sampled and analyzed in the wrong room. Measured by a radioisotope nuclear species analyzer connected to a high-purity germanium detector, the Gama energy spectrum was a single 5111 (^ peak, and the measured half-life was 110 minutes. It was determined to be a fluorine-18 radioisotope, showing that the isotope is from 0 (P, η) nuclear reaction, the specifications of the finished product meet the requirements of the United States Pharmacopeia (half life between 105 ~ 115 minutes) 'and then the total activity of fluorine_18 measured by a vital meter is 824mCi »
實施例4‘_利用實驗例3所獲得氟-18放射性同位素研 製核醫藥物（F-i8)FDG 將如實驗例3，利用本發明裝置傳送 氧-18水至靶腔，經照射分離後，所獲得 的氟-18放射性同位素送入鉛室中的FDG 合成盒裏’再經FDG合成盒的合成操作 程序與添加的藥品反應，最後製成（F-18)FDG核醫藥物，送往台大醫院進行人 體臨床實驗，此實驗從87年10月至88 年3月共實施60次，顯示一切合格正 常。證明本發明裝置照射靶液體傳送操 作運用方便，產品安全可靠。 11 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公茇） ------------ 裝--------訂---------嫂，. (請先閱讀背面之注意事項再填寫本頁} <ίΓ4 08 7 9 Α7 _ Β7 五、發明說明（//) 以上說明僅為了描述本發明的實施例，並非對本 發明的限制，本領域研究人員可在不背難本發明精神 的情況下，對本發明做出各種修改和替代，本發明範 圍由附加的申請專利範圍要求來限定。 由以上說明可知本發明乃提供一種使用上安全可 靠且操作方便之迴旋加速器生產放射性同位素之液體 乾傳送裝置’將對我國核子技術發展有所貢獻。 以上係僅就本發明具體實施例加以說明，並非對 本發明加以限制’精於本技術領域之人士在無背離本 發明之精神與原理下，尚可對本發明做各種之修飾及 變更成替代，凡此修改當視為涵蓋在下列本發明專利 範圍内。 (請先Μ讀背面之注意事項再填寫本頁) — II 訂·！ |丨|!始. 經濟部智慧財產局貝工消费合作社印製 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐）Example 4'_Development of nuclear medicine (F-i8) FDG using the fluorine-18 radioisotope obtained in Experimental Example 3 As in Experimental Example 3, the device of the present invention will be used to deliver oxygen-18 water to the target cavity, and after separation by irradiation, The obtained fluorine-18 radioisotope is sent to the FDG synthesis box in the lead chamber, and then the synthetic operation procedures of the FDG synthesis box are reacted with the added drugs, and finally (F-18) FDG nuclear medicine is produced and sent to the National Taiwan University. The hospital conducted human clinical trials. This experiment was performed 60 times from October 87 to March 88, showing that everything is normal. It is proved that the device of the present invention is convenient to operate and transport the target liquid, and the product is safe and reliable. 11 This paper size applies to China National Standard (CNS) A4 specification (210 X 297 cm) ------------ Loading -------- Order -------- -嫂 ，. (Please read the notes on the back before filling this page} < ίΓ4 08 7 9 Α7 _ Β7 V. Description of the invention (//) The above description is only for describing the embodiment of the present invention, and is not a limitation on the present invention Researchers in the field can make various modifications and substitutions to the present invention without embarrassing the spirit of the present invention, and the scope of the present invention is defined by the scope of additional patent application requirements. From the above description, it can be known that the present invention provides an application A safe, reliable and easy-to-operate cyclotron-produced liquid dry transfer device for producing radioisotopes will contribute to the development of nuclear technology in China. The above is only a description of specific embodiments of the present invention, and is not a limitation on the present invention. Those who have not deviated from the spirit and principle of the present invention can still make various modifications and changes to the present invention and substitute them. All such modifications shall be deemed to be covered by the following patents of the present invention. (Please read the notes on the back first (Fill in this page again) — Order II! | 丨 |! Start. Printed by Shelley Consumer Cooperatives, Bureau of Intellectual Property, Ministry of Economic Affairs This paper size applies to China National Standard (CNS) A4 (210 X 297 mm)