TW327194B - Novel amyloid precursor proteins and methods of using same - Google Patents
Novel amyloid precursor proteins and methods of using sameInfo
- Publication number
- TW327194B TW327194B TW081107696A TW81107696A TW327194B TW 327194 B TW327194 B TW 327194B TW 081107696 A TW081107696 A TW 081107696A TW 81107696 A TW81107696 A TW 81107696A TW 327194 B TW327194 B TW 327194B
- Authority
- TW
- Taiwan
- Prior art keywords
- amyloid precursor
- nucleic acid
- methods
- same
- precursor proteins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/839—Nerves; brain
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Neurosurgery (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87767592A | 1992-05-01 | 1992-05-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
TW327194B true TW327194B (en) | 1998-02-21 |
Family
ID=25370482
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW081107696A TW327194B (en) | 1992-05-01 | 1992-09-29 | Novel amyloid precursor proteins and methods of using same |
Country Status (14)
Country | Link |
---|---|
US (4) | US5656477A (zh) |
EP (1) | EP0584452B1 (zh) |
JP (1) | JP3937459B2 (zh) |
KR (1) | KR100330830B1 (zh) |
AT (1) | ATE221573T1 (zh) |
AU (1) | AU667895B2 (zh) |
CA (1) | CA2095421C (zh) |
DE (1) | DE69332163T2 (zh) |
DK (1) | DK0584452T3 (zh) |
ES (1) | ES2182823T3 (zh) |
NZ (1) | NZ247499A (zh) |
PT (1) | PT584452E (zh) |
TW (1) | TW327194B (zh) |
ZA (1) | ZA933084B (zh) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3277211B2 (ja) * | 1991-11-12 | 2002-04-22 | プラナ・バイオテクノロジー・リミテッド | アルツハイマー病の試験方法と治療方法 |
US6867179B1 (en) | 1994-08-31 | 2005-03-15 | Trustees Of Boston University | Methods of inducing hair growth and coloration |
US7196055B2 (en) | 1994-08-31 | 2007-03-27 | Trustees Of Boston University | Inhibition of apoptosis in keratinocytes by a ligand of p75 nerve growth factor receptor |
US6103689A (en) * | 1994-08-31 | 2000-08-15 | Trustees Of Boston University | Methods of inducing hair growth and coloration |
US5804560A (en) * | 1995-01-06 | 1998-09-08 | Sibia Neurosciences, Inc. | Peptide and peptide analog protease inhibitors |
US5872101A (en) * | 1995-01-06 | 1999-02-16 | Sibia Neurosciences, Inc. | Methods of treating neurodegenerative disorders using protease inhibitors |
US5948763A (en) * | 1995-06-07 | 1999-09-07 | New York University | Peptides and pharmaceutical compositions thereof for treatment of disorders or diseases associated with abnormal protein folding into amyloid or amyloid-like deposits |
EP0866805A1 (en) | 1995-12-12 | 1998-09-30 | Karolinska Innovations AB | PEPTIDE BINDING THE KLVFF-SEQUENCE OF AMYLOID $g(b) |
ATE405664T1 (de) * | 1996-03-28 | 2008-09-15 | Univ Boston | Methoden zur modulation der melaninsynthese |
AU719038B2 (en) | 1996-03-29 | 2000-05-04 | Trustees Of Boston University | Methods for diagnosing and treating Alzheimer's disease |
DE19641180A1 (de) * | 1996-09-24 | 1998-03-26 | Schering Ag | Verfahren zur Darstellung von APP-Sekretase Modulation und deren Verwendung als Mittel zur Behandlung der Alzheimer'schen Erkrankung |
US7005295B1 (en) | 1997-04-16 | 2006-02-28 | Wyeth | β-amyloid peptide-binding proteins and polynucleotides encoding the same |
US6787319B2 (en) * | 1997-04-16 | 2004-09-07 | American Home Products Corp. | β-amyloid peptide-binding proteins and polynucleotides encoding the same |
US7799535B1 (en) * | 1997-12-09 | 2010-09-21 | Arch Development Corporation | Methods for identifying factors that control the folding of amyloid proteins of diverse origin |
KR100768381B1 (ko) * | 1998-09-24 | 2007-10-18 | 파마시아 앤드 업존 캄파니 엘엘씨 | 알츠하이머병 세크레타제 |
DE19856261C1 (de) * | 1998-12-07 | 2000-03-30 | Hoechst Marion Roussel De Gmbh | Aß-Peptid Screening Assay |
US6518011B1 (en) * | 1999-01-13 | 2003-02-11 | Bristol-Myers Squibb Company | Method for screening compounds to identify beta-amyloid production modulators |
US6593512B1 (en) | 1999-03-03 | 2003-07-15 | Cognosci, Inc. | Transgenic mouse expressing human tau gene |
US7060670B1 (en) | 1999-05-05 | 2006-06-13 | Neurochem (International) Limited | Stereoselective antifibrillogenic peptides and peptidomimetics thereof |
FR2796952B1 (fr) | 1999-07-30 | 2003-08-15 | Centre Nat Rech Scient | Nouvelles applications de peptides issus du domaine cytoplasmique du precurseur de la proteine amyloide |
CA2395926A1 (en) * | 1999-12-28 | 2001-07-05 | Curagen Corporation | Nucleic acids containing single nucleotide polymorphisms and methods of use thereof |
CN1315353A (zh) * | 2000-03-24 | 2001-10-03 | 上海博德基因开发有限公司 | 一种新的多肽——人淀粉样糖蛋白9和编码这种多肽的多核苷酸 |
US6713276B2 (en) * | 2000-06-28 | 2004-03-30 | Scios, Inc. | Modulation of Aβ levels by β-secretase BACE2 |
ATE382704T1 (de) * | 2001-02-15 | 2008-01-15 | Univ Chicago | Verfahren zum nachweis in hefe für mittels die proteinfaltung beeinflussen |
EP1793001B1 (en) * | 2001-02-15 | 2011-11-09 | The University of Chicago | Yeast screens for agents affecting protein folding |
US6815175B2 (en) * | 2001-03-16 | 2004-11-09 | Cornell Research Foundation, Inc. | Anti-amyloid peptide antibody based diagnosis and treatment of a neurological disease or disorder |
EP1572937B1 (en) * | 2002-04-09 | 2012-02-08 | The Scripps Research Institute | Motif-grafted hybrid polypeptides and uses thereof |
WO2004013172A2 (en) * | 2002-07-24 | 2004-02-12 | Innogenetics N.V. | Fragments of beta-amyloid as targets for vaccination against alzheimer disease |
EP1633786A4 (en) * | 2002-10-09 | 2007-07-25 | Rinat Neuroscience Corp | METHOD FOR TREATING ALZHEIMER DISEASE WITH ANTIBODIES TO AMYLOID BETA PEPTIDE AND COMPOSITIONS THEREOF |
JP2007521792A (ja) * | 2003-04-16 | 2007-08-09 | ホワイトヘッド・インスティテュート・フォー・バイオメディカル・リサーチ | 異常に切断されたタンパク質を異所性発現する酵母、およびこの用途 |
US20050009110A1 (en) * | 2003-07-08 | 2005-01-13 | Xiao-Jia Chang | Methods of producing antibodies for diagnostics and therapeutics |
US20060035242A1 (en) * | 2004-08-13 | 2006-02-16 | Michelitsch Melissa D | Prion-specific peptide reagents |
US20050112696A1 (en) * | 2003-11-25 | 2005-05-26 | The University Of Texas Southwestern Medical Center | Compositions, methods and assays related to secretase cleavage specificity |
US7807165B2 (en) | 2004-07-30 | 2010-10-05 | Rinat Neuroscience Corp. | Antibodies directed against amyloid-beta peptide and methods using same |
WO2006076683A2 (en) * | 2005-01-13 | 2006-07-20 | Novartis Vaccines And Diagnostics Inc. | Isolation and detection of pathogenic prions |
UY29504A1 (es) | 2005-04-29 | 2006-10-31 | Rinat Neuroscience Corp | Anticuerpos dirigidos contra el péptido amiloide beta y métodos que utilizan los mismos. |
WO2008127251A1 (en) * | 2006-05-05 | 2008-10-23 | Caritas St. Elizabeth's Medical Center Of Boston, Inc. | Reversible inhibition of pyramidal gap junction activity |
AU2009243060A1 (en) * | 2008-04-30 | 2009-11-05 | Novartis Ag. | Assay for pathogenic conformers |
KR101825041B1 (ko) * | 2016-04-07 | 2018-02-02 | 주식회사 바이오솔루션 | 물질 p를 포함하는 상처치유용 약학 조성물 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0779702B2 (ja) * | 1986-11-17 | 1995-08-30 | サイオス ノバ インコーポレイテッド | 組換えアルツハイマーアミロイドタンパク |
US5223482A (en) * | 1986-11-17 | 1993-06-29 | Scios Nova Inc. | Recombinant Alzheimer's protease inhibitory amyloid protein and method of use |
US4864859A (en) * | 1988-07-25 | 1989-09-12 | Allied-Signal Inc. | Method for dynamically balancing a mechanism having a high speed rotating component |
WO1990001540A1 (en) * | 1988-08-11 | 1990-02-22 | California Biotechnology Inc. | Method for stabilizing heterologous protein expression and vectors for use therein |
EP0447836A3 (en) * | 1990-03-12 | 1991-10-02 | American Cyanamid Company | Amyloid peptide precursor rna |
EP0451700A1 (en) * | 1990-04-10 | 1991-10-16 | Miles Inc. | Recombinant APP minigenes for expression in transgenic mice as models for Alzheimers's disease |
US5242932A (en) * | 1991-12-17 | 1993-09-07 | The Rockefeller University | Treatment of amyloidosis associated with alzheimer disease |
CA2086165A1 (en) * | 1992-04-09 | 1993-10-10 | Paul P. Tamburini | Diagnostic assay for alzheimer's disease based on the proteolysis of alzheimer's precursor protein |
-
1992
- 1992-09-29 TW TW081107696A patent/TW327194B/zh active
-
1993
- 1993-04-07 DE DE69332163T patent/DE69332163T2/de not_active Expired - Fee Related
- 1993-04-07 ES ES93105718T patent/ES2182823T3/es not_active Expired - Lifetime
- 1993-04-07 DK DK93105718T patent/DK0584452T3/da active
- 1993-04-07 PT PT93105718T patent/PT584452E/pt unknown
- 1993-04-07 AT AT93105718T patent/ATE221573T1/de not_active IP Right Cessation
- 1993-04-07 EP EP93105718A patent/EP0584452B1/en not_active Expired - Lifetime
- 1993-04-27 NZ NZ247499A patent/NZ247499A/en unknown
- 1993-04-30 ZA ZA933084A patent/ZA933084B/xx unknown
- 1993-04-30 JP JP12793493A patent/JP3937459B2/ja not_active Expired - Fee Related
- 1993-04-30 KR KR1019930007583A patent/KR100330830B1/ko not_active IP Right Cessation
- 1993-05-03 CA CA002095421A patent/CA2095421C/en not_active Expired - Fee Related
- 1993-05-03 AU AU38358/93A patent/AU667895B2/en not_active Ceased
- 1993-09-20 US US08/123,659 patent/US5656477A/en not_active Expired - Lifetime
-
1995
- 1995-06-05 US US08/464,248 patent/US5703209A/en not_active Expired - Lifetime
- 1995-06-05 US US08/462,859 patent/US5652092A/en not_active Expired - Lifetime
- 1995-06-05 US US08/464,247 patent/US5693478A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP3937459B2 (ja) | 2007-06-27 |
ES2182823T3 (es) | 2003-03-16 |
ZA933084B (en) | 1993-11-24 |
JPH07132094A (ja) | 1995-05-23 |
US5703209A (en) | 1997-12-30 |
CA2095421A1 (en) | 1993-11-02 |
NZ247499A (en) | 1996-04-26 |
ATE221573T1 (de) | 2002-08-15 |
US5693478A (en) | 1997-12-02 |
KR100330830B1 (ko) | 2002-11-23 |
EP0584452B1 (en) | 2002-07-31 |
CA2095421C (en) | 2008-11-18 |
PT584452E (pt) | 2002-12-31 |
KR930023460A (ko) | 1993-12-18 |
US5656477A (en) | 1997-08-12 |
DE69332163T2 (de) | 2003-02-27 |
DK0584452T3 (da) | 2002-11-18 |
US5652092A (en) | 1997-07-29 |
AU3835893A (en) | 1993-11-04 |
EP0584452A1 (en) | 1994-03-02 |
AU667895B2 (en) | 1996-04-18 |
DE69332163D1 (de) | 2002-09-05 |
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