TW316840B - - Google Patents

Description

316840 A7 B7 V. Description of the invention (3 domains of the arts and crafts of Mingfa include all the special medicines, pharmaceuticals and agricultural types. 0 If ·-species 1 Yuguan Shiming is the author of the Mflw R taboo combination system is divided into Sexually active medicines. The preparation of agricultural agents, M, farming, two stable, stable, and only species that can only be used in addition to medicines. The method of killing Guanghe's agent to kill insects is as good as the example. The cloth for the preparation of several medicines is dispersed into medicinal agricultural activities, less medicine and less agricultural M. It can be included in a single, including foreign compound. Divided into parts, sex knows the truth and confirms the medicine, the agricultural use of the combination of the M-mixing agent kills two insects like a worm. Agro-stabilizers are often used in mixed systems until the mixed system reaches the law and the taboo cannot be forbidden, but there is no match for the three sexes. That's right. With I's sub-heading results Rabbi Tenny Know already d E / ί \

Bit-based A-3-chloro (please read the precautions on the back before filling in this page) Pyridine-B Insect Infestation Good You You have t ~ \ Aminodiene Ethylnitros-2-yl A

Btb and other agents fungicides or insecticides and other pesticides can be used in addition to the production of powdered ore and M agents that can be used in the printing and printing of minerals and M agents of the Central Standards Bureau of the Ministry of Economic Affairs. The agent is especially flat, mixed with solid and other kinds of agent. The same amount of agent is used to increase the particle size, particle size and load. Sexual dissolution) ° Dissolved water report water, public, agent No. agricultural D 1 ^ ί 7 powdered water I sex, M for workable, the amount of La Yibi, Tian Li Ni M easy to mention, has been prepared. For the simple medicine Yunong's Benrajanbi, use Tian Shini, dusty and powder-proof anti-opening special / c \ for example, the granules are made of soluble water and the sugar milk is} Prospective bidder Guozhong uses a moderate ruler of paper on one centimeter. 3 Printed 316S40 A7 B7 by the Employees ’Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs. 5. Description of the invention (4). Pesticide formulations of ingredients and other pesticide active ingredients are expected to develop more stable pesticide formulations that can more effectively inhibit the decomposition of these pesticide active ingredients. [Invention to solve the problem] The purpose of the present invention is to combine pesticide active ingredients (I) containing two or more pesticide active ingredients, for example, pesticide active ingredients (I) containing Nitinyl Bira and the like with the pesticide active ingredients (I) The taboo-based pesticide active ingredients (II) are contraindicated to provide a stable new pesticide formulation that can suppress the decomposition of these pesticide active ingredients. [Methods for Solving the Problem] The inventors determined to review the above-mentioned problems and found out that, in a formulation containing two kinds of pesticide active ingredients on K, if one of the pesticide active ingredients is M, cyclodextrin is used. Inclusion of compounds can inhibit the decomposition of these pesticide active ingredients. In particular, in a mixed preparation in which Nitian Bila and other pesticide active ingredients are mixed, Nitin Bila is first wrapped with a cyclodextrin compound, and then mixed with other pesticide active ingredients. Decompose to stabilize Nitta Bira. The present inventors have further found that if other pesticide active ingredients are those that are contraindicated with Nitian Bila, the stabilizing effect is more significant. The inventors based on this viewpoint and conducted a more in-depth review, and as a result, completed this invention. That is, in the present invention, in a pesticide preparation containing two types of pesticide active ingredients on M, all pesticide active ingredients are encapsulated with cyclodextrin, or only one or more of them The active ingredients are encapsulated with cyclodextrin, and the rest of the pesticide active ingredients are not encapsulated. The paper size is applicable to the Chinese National Standard (CNS) Α4 specification (210Χ297 mm) m II.--I --- =- -HI "丨--In _ (please read the precautions on the back before filling in this page) • ^^ 1 ^ — — ^ — ^ 1 ϊ 1 nn ^^^^ 1 · \ νβ”-4 A7 B7 5. Description of the invention (5) Pesticide preparations. (1) A stable agricultural preparation, characterized in that: in a pesticide preparation containing two or more pesticide active ingredients, one of the pesticide active ingredients is K [pesticide active ingredient (I)], which is cyclodextrin Compounds are included. (2) The stable pesticide formulation as described in item (1), characterized in that the two types of pesticide active ingredients on M are related to contraindications. (3) The stable pesticide formulation as described in item (1), which has the following two characteristics: (A) 1 part of the pesticide active ingredient (I) is encapsulated with about 1-20 parts of cyclodextrin compound The resulting pesticide active ingredient (I) inclusions,

I is about 0.1 ~ 95% by weight of the total preparation; (B) contains pesticide active ingredient (I) Pesticide active ingredient UI other than K), the amount is about 0.1 ~ 95% by weight of the total preparation. (4) The stable pesticide formulation as described in item (3), characterized in that: the pesticide active ingredient (I) and the agricultural active ingredient (II) are related to the contraindication. Printed by the Employee Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs (please read the precautions on the back before filling out this page) (5) The stable pesticide formulation as described in items (1) to (4), its pesticide active ingredient (I) One or more pesticide active ingredients are selected from the following pesticide active ingredient combination groups: nitenpyram, carbaryl, carbofuran, carbofuran Furathiocarb, carbosulfan, fenthion, fenitrothion, acephate, and pine (this paper scale is applicable to China National Standard (CNS) A4 specifications ( 210X297mm) 5 316840 A7 B7 V. Description of invention (6) (please read the notes on the back before filling in this page) phenthoate printed by the Employee Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs), marathon, and marathon ( dimethoate), diazinon, pyridaphenthion, isoxathion, permethrin, cyhalothrin, fenvalerate, flucyt hrinate), cartap, buprofezin, etofenprox, fthalide, validamycin A, tricyclazole, tricyclazole Probenazole, bensultap, pyraclophos, ferimzon, imidacloprid, silafluofen, cycloprothrin, Aker (Acrinathrin) -cycloprothrin (cycloprothrin), thiabendazole, iprodione, paclobutrazole, hexaconazole, tefluthrin, trimethoprin ( vamidothion), trichloroform (DEP), diquat, BPMC, methomyl, and bialaphos 0 (6) such as item (1) ~ item ( 4) The stable pesticide formulation described in item 4, whose pesticide active ingredient (I) is selected from one or two types of pesticide active ingredients on M from the following pesticide active ingredient combination group: Nitta Bira, Susu Thai, Haosheng, Fulazon, Fuli Song, Fudede, Vida Emblem A, tricyclazole and trusted by satisfied. (7) The stable pesticide formulations as described in items (1) to (4), which are characterized by 6 paper scales applicable to the Chinese National Standard Falcon (CNS) A4 specification (210X297 mm) Employees of the Central Bureau of Standards of the Ministry of Economic Affairs A7 B7 printed by the consumer cooperative. V. Description of the invention (7): The active ingredient of the pesticide (I) is Nitta Bira. (8) A stable k-pharmaceutical preparation as described in items (1) to (4), characterized in that the pesticide active ingredient (I) is Nitabira, and the pesticide active ingredient (II) is composed of Those who selected more than one kind of pesticide active ingredient from the combination group of Dansuan acid, Susutai, Fulazon, Haosheng, Fusong / Fulaxone mixture group. (9) The stabilized pesticide formulation as described in items (1) to (4), whose pesticide active ingredient (I) is pedan sulfate, sutai-free, Fulazon, Fulisong / Fulaxide A pesticide active ingredient on M is selected from the mixture group, and the pesticide active ingredient (II) is Nitta Bira. (10) The stable pesticide formulation as described in items (1) to (9), wherein the cyclodextrin compound is α-cyclodextrin, / 3-cyclodextrin, 7-cyclodextrin or these rings Compounds or mixtures of these compounds that have been chemically modified by dextrin. (11) The stable pesticide formulation as described in the items (1) to (9), wherein the cyclodextrin compound contains 20% by weight of α-cyclopentin. (12) The stable pesticide formulation as described in items (1) to (11), which also contains a surfactant. (13) Stable pesticide formulations as described in items (1) to (12), also containing extenders. (14) The stable pesticide formulation as described in items (1) to (13), wherein the pesticide formulation is a powdered water solvent, a water additive, a powder DL, a granule, a water-soluble granule or a granulated water and Agent. (15)-A stable pesticide formulation, which is characterized by: the size of the ring paper containing Nitin Bila is applicable to the Chinese National Standard (CNS) A4 specification (210X297 mm) I ------- 1 Pack- ---- TJTI.1 ----- i (Please read the precautions on the back before filling in this page) 7 316840 A7 B7 5. Description of the invention (8) Those with dextrin inclusions. Specifically, the present invention provides one of the following type of pesticide formulations: (16) the stable pesticide formulations described in items (1) to (2), 1 part of the pesticide active ingredient (I), It is the one that contains 1 ~ 20 parts of the compound of ring shed essence. (17) The stable pesticide formulation as described in items (1) to (10), whose cyclodextrin compound is one or a mixture of two selected from the following compound combinations: α-ring Dextrin, / 3-cyclodextrin, 7-cyclodextrin, (1,2, or 3) -methyl-cc-cyclodextrin, (1,2, or 3) -methyl- / 3-cyclodextrin , (1, 2 or 3) -methyl-7-cyclodextrin, hydroxypropyl-cx-cyclodextrin, hydroxypropyl-3 / cyclodextrin, hydroxypropyl-7-cyclodextrin, Portuguese Glycosyl-α-cyclodextrin, glucosyl- / 9-cyclodextrin, glucosyl-7-cyclodextrin, maltosyl-α-cyclodextrin, maltosyl- / 3-cyclodextrin, maltose Base-7-cyclodextrin, poly-α-cyclodextrin, poly- / 9-cyclodextrin, poly-7-cyclodextrin Ο Printed by the Employee Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs (18) as (1) ) Item ~ The stable pesticide formulation according to item (9), wherein the cyclopentin compound is a mixture of ct-cyclodextrin, / 3-cyclodextrin, 7-cyclodextrin or maltosyl-α-cyclodextrin Those who are fine alone. (19) The stable pesticide formulation as described in items (1) to (9), whose cyclodextrin compound is dodolin-P (Toyodelin Ρ (trade name) (manufactured by Asahi Food Co., Ltd.), or Isoori-P (Is〇eleate Ρ (trade name) (manufactured by Dayang Fishery Co., Ltd.). 8 (Please read the precautions on the back before filling out this page) This paper standard is applicable to China National Standard (CNS) Α4 specifications ( 210X297mm) A7 B7 V. Description of the invention (9) (20) The stable pesticide formulation as described in items (1) to (4), the active ingredient of the pesticide (I) is the Pedandan acid, pesticide The active ingredient (II) is Niten Bila, Fulazon, Fuli Pine, Victory or Nanoder. (21) The shuttlecock-type pesticide formulation as described in items (1) and (4), which Pesticide active ingredients (I) are superior, and pesticide active ingredients (II) are those of Nitian Bila, Pedan 塩 酸 塩, Fulazon or Fuli Song. (22) Such as items (1) ~ (4) In the stable pesticide formulation, the active ingredient (I) of the pesticide is fulofone, and the active ingredient (II) of the pesticide is nitenbila, pedan, fulazone, or winner. (23) The stabilized pesticide formulation as described in items (1) to (4), wherein the pesticide active ingredient (I) is Fulazon, and the pesticide active ingredient (II) is Nitabira, Pedanuric acid Pang, Fulison, Victory or Tricyclazole. (24) The stable pesticide formulation as described in items (1) to (4), the pesticide active ingredient (I) is Sutai free, pesticide activity Ingredient (II) is Nitta Bira, Fulison, Fulazon or the winner. Central Government Bureau of Economic Affairs Employee Consumer Cooperatives (Please read the precautions on the back before filling out this page) (25) as the first (1 ) ~ Barley stereotype pesticide formulation as described in item (25), the pesticide active ingredient (I) is the pesticide activity after 1 part of the pesticide active ingredient (I) K 2 ~ 10 parts of cyclodextrin compound is encapsulated Ingredients (I). (26) Ear-setting pesticide formulations as described in items (1) to (25), which further contain surfactants. (27) As described in items (1) to (26) ) The stable pesticide formulation described in the item, the surfactant is a nonionic or anionic surfactant with a hydrophilic-lipophilic balance (HLB) value of 4 to 12. (28) Item (1) ~ Item (26) of the cymbals stereotype pesticide formulations, the standard paper size applicable to the Chinese National Standard (CNS) Α4 specifications (210X 297 mm) 9 A7 316840 B7 V. Description of the invention (1 ( )) Surfactants are New-caigen 9131 (bamboo fat), New-card EP-70P (bamboo fat), New-Baka BX-CC bamboo-based fat), New card world HU-410 (bamboo-based fat) ), New Card World EX-70 (Bamboo Oil), New Card World PS-P (Bamboo Oil), New Card World NX405H (Bamboo Oil), New Card World NX-250 (Bamboo Oil), New Card World NX-360 (Bamboo oils and fats), New-Pole PE-64 (Sanyo Chemicals) or Songpol (Solpol) 5 1 1 5 (Toho Chemical). (29) The stable pesticide formulations as described in items (1) to (26), the surfactants are New Card World NX-360 (Takemoto Oil), Matsuba 5115 (Toho Chemical), New Card World BX-C (bamboo fat) or New Card World EP-70 P (bamboo fat). (30) The stable pesticide formulation as described in items (1) to (29), further containing extenders. (31) The stable pesticide formulation as described in item (30), where the extender is clay, calcium carbonate, lactose, sodium bicarbonate, talc, bentonite, or radiofanite. (32) The stable pesticide formulation as described in (31), where the extender is lactose, sodium bicarbonate, calcium carbonate, or clay for DL. (3 3) The stable pesticide formulation as described in item (2 6), characterized in that: the weight of the surfactant contained in it is 0.05% to 20% by weight of the total pesticide formulation. (34) The stable agricultural formulation according to item (33), characterized in that the weight of the extender contained is 1 to 99.9% by weight of the total amount of the pesticide formulation. 10 I Pack ---; --- 7 Order ------- ^ (Please read the precautions on the back before filling in this page) The paper standard printed by the Employee Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs is applicable to Chinese national standards (CNS) A4 specification (210X297mm) The paper standard printed by the Employee Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs is applicable to the Chinese National Standard (CNS) A4 specification (210X297 public acid) A 7 B7 V. Description of invention (1 1) (35) The stable pesticide formulation as described in items (1) to (34), the dosage form of which is a powdered water solvent, water additive, powder DL, granule, water-soluble granule or granule water additive By. (36) The stable pesticide formulation as described in item (35), which is in the form of powdered water solvent, water admixture or powder DL. (37) The shuttle-type pesticide formulation as described in item (1), which is a powdered water solvent containing Nidantyl Bira, cyclodextrin compound encapsulated, Pedandan acid and lactose. (38) The stabilized pesticide formulation as described in item (1), which contains Nitta Bira, Susutai, Xinkajie NX-360 (bamboo oil) and bicarbonate encapsulated with a cyclodextrin compound The water and the agent are satisfied. (39) The stable pesticide formulation as described in item (1), which contains Nitta Bira encapsulated with a cyclodextrin compound, Fuli Song / Fu Shade, Matsuba 5115 (Toho Chemical), Xinka BX-C and sodium bicarbonate water additives 0 (40) The stable pesticide formulation as described in item (1), which contains Nitta Bira, Fuli Song / Fushade, Xinkajie EP-70 P (bamboo fat), white carbon, Desanong L (t ο X a η ο n L), IP solvent and sodium bicarbonate powder DL.

(41) The stabilized pesticide formulation as described in item (1), which contains Nitta Bira encapsulated with a cyclodextrin compound, Fuli Song / Fu Shao De, Pedandan Acid, New Card World EP- 7 0 P (bamboo oils and fats), white carbon, Desanon L, IP solvent and DL clay powder DL. A stable pesticide preparation of the present invention, the pesticide active ingredient (I) used for inclusion is 11 III ------ ^ 1¾ clothing-- (please read the precautions on the back before filling this page), νβ 316840 A7 B7 V. Description of invention (12) All the active ingredients of pesticides described below: (Please read the precautions on the back before filling out this page) Insecticides [Pyrethrum Insecticide Insecticide, Organic Phosphate Insecticide Insecticides, carbamate insecticides, natural insecticides, etc.], fungicides [such as: copper-based fungicides, organochlorine-based fungicides, organic sulfur-based fungicides, phenol-based fungicides, etc.], weeding Agents, acaricides, nematicides, phytohormones, plant growth regulators, adjuvants, attractants, repellents, pigments, fertilizers and all other pesticide active ingredients. The active ingredients of the pesticides listed above are specifically listed as follows: Nitta Bira, Kapoli, Kabofula, Fula interest plus, Kabaoshafan, Fenzapine, Fulazon, Victory, Fansong, Marathon , Dameon, dalinong, bifensone, albizone, permethrin, sihanin, fenhuali, fusipendan, fenfei, pufeili, yifenpu, fusode, vidahui A, tricyclazole, propazole, susutai, pirafu, fulofone, imicli, sirafufen, cycloprine, aknin-cycloprine, rot, iproton, ba Copazole, hexaconazole, defenin, triamcinolone, trichloroform, dauran, butyl metronidazole, nanode and bilafosone. Among the pesticide active ingredients listed above printed by the Staff Consumer Cooperative of the Ministry of Economic Affairs of the Central Bureau of Standards, ΜPedandan acid, Nitian Bila, Susutai, Haosheng, Fulazon, Fusong, Fusong, Wei Dahuisu A, tricyclazole, nanolide etc. are more ideal. Among them, it is more ideal for Pei Dandan sour, Nitian Bila, Fang Sutai, Fulazon, Haosheng, Fuli Song, Fusong etc. Nitin Bila is the most suitable. In Japanese Patent Laid-Open No. 2-171, it is stated that a-unsaturated amines can be used, specifically, the compounds synthesized in Examples 1 to 1 1 2 can be used to replace the Niben paper scale and the Chinese National Standard (CNS) Α4 specification is applicable. (210Χ297mm) 12 ^ 16840 a7 __B7_ V. Description of the invention (13) Tian Bila. Nitin Bila is the compound number 60 ° produced in Example 41. It is used in two or one kinds of use, so that Μ〇 可} The Shang Shang M agent is divided into a medicinal agricultural active medicine, Ding Nong. The Ming Ming is based on the description of the second seed or the f 1 species. It is characterized by its compound and mixed sperm ring Μ 接 包 想 行 Η 理 隹^ Most in) ί is (I is subcontracted into a line-by-line action, and it ’s a different kind of medicine. It is said that the two points are the two sexes. If the person is stable, then from the package, the time agent., The refined medicine paste agricultural ring type-Dingwen The original version of α is the substance r. The use of fine-glued ring to make fine-glued ring makes it fused with this or fine-glued ring. For the mixed paste, please use this or (please read the precautions on the back before filling in this page) α It is better to use 3, the most suitable and suitable for the most suitable sex ratio% package 8- fine 20 paste with ring Containing-or α-substance alone refined ring

For those who mix the materials, the fine paste ring II α α is used to make the amount of il S fine paste ring to be the fine paste ring. I 7 Isometric media machine printed by the employee consumer cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs There is water, gluing cyclization to the fine substance • The fine gluing ring has a high product α. For sale, it ’s the market, generally decorated with a repair θ ·, the fine gluing ring has become a fine gluing ring-7 It can be used to make the original commodities and compounds can be combined with refined dextrins and ring shadows. The decoration is not repaired and the chemistry is over-dissolved. The special characteristics of the Reitz limit are not similar-Ϊ * -Kind of. Decorate the Chinese medicine to make the chemical medicines based on the formation of metamorphic hydroxy groups based on the sugar: the three kinds of refined triglycerides in the next ring ① or the paper size is applicable to China National Standards (CNS) Α4 specifications (210Χ297mm) The paper standard printed by the Employees ’Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs, the General Chinese National Standard (CNS) Α4 specification (210X 297 mm) A7 __B7_ V. Description of the invention (! 4) Methyl- (α-, Or 7-) cyclodextrin and hydroxypropylated hydroxypropyl- (CC-, / S- or 7-) cyclodextrin etc. ② Glucosyl- (α-, / 3- or 7_) cyclodextrin and maltyl, / 3- or 7-) cyclodextrin made by introducing water-soluble substances such as glucose and maltose into the side chain of cyclodextrin And other branched-chain cyclodextrins. ③ Poly-(«_, or 7-) cyclodextrin etc. cross-linked and polymerized with epichlorohydrin etc. for cyclodextrin. Among them, glucosyl _ («-, or 7-) cyclodextrin and maltyl_ (α-, / 3- or 7-) branched cyclodextrins such as cyclodextrin are preferred, among which maltyl-(«-, / 3- or 7_) cyclodextrin ν is the best. In the stabilized pesticide formulation of the present invention, the cyclodextrin compound described above may be used alone or as a mixture of two kinds of M. For example, when a single type of maltyl-α-cyclodextrin is used, commercially available products such as Isopril-P (trade name, manufactured by Dayang Fishery Co., Ltd.) and the like can be used. When using a compound containing two or more cyclodextrins in an appropriate ratio, a compound such as ex-cyclodextrin, / 3-cyclodextrin, cyclodextrin, or maltyl-α-cyclodextrin, maltyl can be used Cyclodextrin, mixture of maltyl-7-cyclodextrin, etc. A mixture of α-cyclodextrin, / 3-cyclodextrin and 7_ cyclodextrin can be obtained from commercially available products such as Dodolin_P (trade name manufactured by Asahi Food Co., Ltd.). The cyclodextrin compound used in the stable pesticide formulation of the present invention is 14 I ί " Μ Ί ^ --- (please read the precautions on the back before filling in this page) A7 B7 5. Description of the invention (15), in Among the compounds listed above, maltyl-α-cyclodextrin alone, α-cyclodextrin, 々-cyclodextrin, 7: a mixture of cyclodextrins or maltyl-ex-cyclodextrin, The mixture of maltyl- / 3-cyclodextrin and maltyl-7-cyclodextrin is ideal. Specifically, maltyl-ex-cyclodextrin alone is the best commercially available product such as Isodol-P (trade name, manufactured by Dayang Fishery Co., Ltd.). 〇 (-Cyclodextrin, / 3-cyclopentin, γ-cyclodextrin is the best mixture of commercially available products such as Dodolin-Ρ (trade name Asahi Food Co., Ltd.), etc. Cyclodextrin compound When manufacturing the pesticide active ingredient (I) to be encapsulated, 1 part of the pesticide active ingredient (I) is generally about 1 to 20 parts of M, preferably about 2 to 20 parts, and most preferably about 5 to 10 parts of the ring The dextrin compound is mixed by a method known per se. For example, the pesticide active ingredient (I) encapsulated with the cyclodextrin compound can be mixed by a well-known method such as kneading method or mist drying method. Ministry of Economic Affairs When the mixing method is printed by the Central Bureau of Standards ’Staff Consumer Cooperative, for example: a mixture of pesticide active ingredient (I) and cyclodextrin compound, M 100 parts by weight, and about 3 to 20 parts by weight of water is added for mixing. About 5 0 ~ 7 0 It is dried and crushed with M to obtain M pesticide active ingredient (I) inclusions encapsulated with cyclodextrin compound. When spray drying method is used, for example: Pesticide active ingredient (I) ) And cyclodextrin compound, add about 50 ~ 1000 parts by weight of water to 100 parts by weight The ratio is dissolved, the aqueous solution is spray dried, and the powder is granulated to obtain the pesticide active ingredient (I) inclusions encapsulated with the cyclodextrin compound. This paper wave scale is applicable to China National Standard (CNS) Α4 specifications (210Χ: 297mm) (Please read the precautions on the back before filling in this page) 15 A 7 B7 5. Description of the invention (16) The stable pesticide formulation of the present invention uses the pesticide active ingredient (II), except Any pesticide active ingredient other than the ingredient used as the pesticide active ingredient (I) can be used as M. Therefore, among the pesticide active ingredients (I) listed above, other than the pesticide active ingredient (I) Pesticide active ingredients can be appropriately selected as the pesticide active ingredient (II). Generally, the pesticide active ingredient (I) and the pesticide active ingredient with a contraindication are not easily mixed directly, or the desired effect cannot be obtained. The present invention One of the characteristics of the stable pesticide preparation is: the pesticide active ingredient (I) is encapsulated with a cyclodextrin compound, even if it is related to the pesticide activity that has a contraindication. It can also be mixed easily by mixing. Therefore, when selecting the pesticide active ingredient (Π), choose one or two kinds of PK with the pesticide active ingredient (I) encapsulated with the cyclodextrin compound. Taboo-related pesticide active ingredients (II) are the most ideal. The Ministry of Economic Affairs Central Standards Bureau employee consumer cooperative prints the so-called compound taboo relationship in the present invention: two types of pesticide active ingredients on M will affect each other and make their pesticide active ingredients For example, at 40C, after three months, the content of at least one kind of pesticide active ingredient is reduced by more than about%, compared with more than 30%, and more severely. When more than 50%, it is said to have a taboo relationship. Therefore, the more the two or more pesticide active ingredients are combined, and the greater the degree of reduction in the content of the pesticide active ingredients, the more effective the cymbals stereotyped pesticide preparation of the present invention. The following is a list of some pesticide active ingredients that are compatible with the taboo relationship. This paper scale is applicable to the Chinese National Standard (CNS) Α4 current format (210X 297 mm) (please read the precautions on the back before filling this page) 16 316840 A 7 B7 5 , Invention description (1 7) combination. But it is not limited to these combinations. (Please read the precautions on the back before filling in this page) ① Pesticide active ingredient (I) is Niten Bira, Pesticide active ingredient (Π) is Pedandan acid, Sutai-free, Fulazon, Victory or welfare Song / Fu killer. ② Pesticide active ingredient (I) is Pedan citrate acid salt, and Pesticide active ingredient (I I) is Nitta Bira, Fulazon, Fuli pine, Victory or Nanoder. ③ Pesticide active ingredient (I) is superior, and pesticide active ingredient (II) is Nitin Bila, Pedandan acid, Fuchu pine or Fuli pine. ④ Pesticide active ingredient (I) is Fusong, Pesticide active ingredient (II) is Nitian Bila, Pedandan acid, Fulazon or winner. ⑤ Pesticide cleansing ingredient (I) is Fulazon, Pesticide active ingredient (II) is Nitenbila, Pedan 塩 酸 塩, Fulicon, Victory or tricyclazole 0 ⑥ Pesticide active ingredient (I) is exempt Sutai, the active ingredient of pesticide (II) is Nitta Bira, Fuli Song, Fulazon or the winner. The Nitta Bira listed above is printed by the Staff Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs. Have to wait for mixing. However, according to the present invention, the inclusion of Nidantyl Bira with a cyclodextrin compound can further improve the stability of Nidan Bira. As mentioned above, although the general preparations can also be mixed, the present invention provides that using the technology of the present invention, the stability of the pesticide active ingredient (I) and the pesticide active ingredient (II) can be improved. Active ingredients (I) and other pesticide active ingredients (I) and pesticide active ingredients This paper scale is applicable to the Chinese National Standard (CNS) A4 specification (21〇297 mm) 17 Printed by the Ministry of Economic Affairs Central Standards Bureau Employee Consumer Cooperative A7 B7 Fifth, the description of the invention (18) (II) must be a person who has a taboo relationship. Furthermore, the stable pesticide formulation of the present invention may contain one or more pesticide active ingredients (II), which may be encapsulated with a cyclodextrin compound like the agricultural chain active ingredient (I) described above. . In the stabilized pesticide preparation of the present invention, the content of the pesticide active ingredient (I) to be encapsulated by the K cyclodextrin compound, based on the inclusions, generally accounts for about 0.05 to 95% by weight of the total amount of the pesticide preparation, and about 0.1 to 80 The weight% is better, preferably about 0.2 ~ 50 weight? ί. Therefore, in the stable pesticide formulation of the present invention, the content of the pesticide active ingredient (I) generally accounts for about 0.001 ~ 50% by weight of the total amount of the pesticide formulation, preferably about 0.005 ~ 40% by weight, most preferably about 0.01 ~ 25 weight? ί. The content of the pesticide active ingredient (II) of the cymbals stereotyped pesticide preparation of the present invention generally accounts for about 0.01 to 95% by weight of the total pesticide preparation, and the K is about 0.05 to δ0% by weight, preferably about 0.1 ~ 50% by weight 0 The stable pesticide formulation of the present invention preferably contains surfactants, extenders, pigments, binders, ultraviolet absorbers and other commonly used pesticide supplements. As for the surfactant, although it is not particularly limited, for example, nonionic or anionic surfactants with a hydrophilic-lipophilic balance (HLB) value of 4 to 12 are generally used. Specifically, such as: New Card World 9131 (trade name, bamboo oil and fat), New Card World EP-70P (trade name, bamboo oil and fat), New Card World BX-C (trade name, bamboo oil and fat), New Card World 0-410 (trade name, bamboo oil and fat), New Card World EX- This paper scale is applicable to the Chinese National Standard (CNS) Λ4 specification (210X25 »7mm) 18 (Please read the precautions on the back before filling this page) . · Order

U The standard paper printed by the Xiaoxian Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs is applicable to the Chinese National Standard (CNS) Α4 specification (210X297 mm) A 7 __B7_ V. Description of invention (19) 70 (trade name, bamboo fat), new card World PS-P (trade name, bamboo oil), New Card World NX405H (trade name, bamboo oil), New Card World NX-250 (trade name, bamboo oil), New Card World NX-360 (trade name, bamboo oil) ), Sinbo PE-(3 4 (trade name, Sanyo Chemicals) or Matsushita 5115 (trade name, Toho Chemical), etc. Among them, M Xinkajie NX-360 (Takemoto Oil), Matsushita 5 1 1 5 (Toho Chemical ), New Card World BX-C (Bamboo Fats and Oils), New Card World EP-70P, etc. As an extender, although it is not particularly limited, usually, for example, solid support, etc. As for solid support , Generally used as follows: ① Plant powder: for example: soybean powder, tobacco powder, wheat flour, wood powder, etc. (. ② mineral powder: (i) clay: such as: clay, bentonite, acid clay, radiofan rock, etc. (Ii) Talc: such as: talc powder, wax stone powder. (Iii) Oxygen Silicones: such as: diatomaceous earth, mica powder, etc. ③ lactose, sodium bicarbonate, calcium carbonate, alumina, sulfur powder, activated carbon, etc. The above extenders can be selected from one or two types of K, as appropriate Mixing ratio of these. Among these extenders, Μ clay, calcium carbonate, lactose, sodium bicarbonate, talc, bentonite, and radiofanite are preferred, among which, lactose, sodium bicarbonate, calcium carbonate, or DL clay Wait for the most ideal ° 19 (please read the precautions on the back before filling this page)

.W Printed by the Beigong Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs A7 B7 V. Description of invention) As for the coloring matter, specifically, Aningreen-G (trade name manufactured by Sumitomo Chemical Industry Co., Ltd.) is generally used. As for the binding agent, specifically, hydroxymethyl cellulose sodium, alpha starch, sodium lignosulfonate, dextrin, polyvinyl alcohol, gum arabic, sodium alginate, polyvinylpyrrolidine, lactose, Sucrose, mannitol, sorbitol, etc. The content of the surfactant is generally about 0.05 to 20% by weight of the total amount of the pesticide preparation, and M is preferably about 0.1 to 10% by weight. The content of the bulking agent generally accounts for about 1 to 99.9% by weight of the total amount of the pesticide formulation, preferably about 20 to 80% by weight. The content of the pigment generally accounts for about 0.01 to 0.5% by weight of the total amount of the pesticide preparation, and M accounts for about 0.01 to 0.1% by weight. The content of the binding agent generally accounts for about 0.1 to 10.0% by weight of the total amount of the pesticide formulation, and M is preferably about 0.5 to 7.0% by weight. The stabilized pesticide preparation of the present invention can be made into a powdered water solvent, water additive, powder DL, granule, water-soluble granule or granular water additive according to a general pesticide preparation manufacturing method. Its M powdered water solvent, water additive, powder DL, etc. are ideal. For example: According to "Pesticide Powdered Granular Formulation" (Anda Hiroshi, Japan Pesticide Society Journal 7, 2U-218U982)), "Pesticide Formulation and Production Technology" (Kamada Yu%, January 26, 1958, RIKEN topic Academic proceedings) etc., or these methods as standard, can be formed. The specific formulations of the Ka-type pesticide formulations of the present invention, and their specific examples (please read the precautions on the back before filling in this page). Binding \ Order Μ This paper size is applicable to China National Standard (CNS) Α4 specification (2ΙΟΧ297mm) 20 Fifth, the invention description (21) A7 B7 The Ministry of Economic Affairs Central Standards Bureau staff consumer cooperatives printed the Thai. Pine carbon pine sand pine I) No tea in the extraction period Jim ο Dansu agent and benefit ML can be farmer, cultivating, mellow-C-fu, Fuben ^ 1D planting-can be used in fields,, Water, BX., Carbon, | * powder harm, with the pull of the water pull La La La La (tM, no agent,., Bibinapicabi, Bio ± agents also control the amount of insects • Tiantian Hydrogen Field Xintian I) The medicinal harm after the preparation of Tian-7 was selected as one of Nininic acid and Niñoni ΕP. The carbon} ㈣ LO boundary Lffl agricultural application type is suitable for connection. Connected and connected to the W card SD type or fixed spoon, suitable for the package of the package 丨 包包 包 ί package of new time-stabilized-Θ agent to do the state purpose> hope the medium to go up the line ΛΙ line line, Stable seed production, the original influent into the M (3 into -7 into the P · 'Ming Shiming hanging medicine, etc. of the same thing ^ 15 things Epf acid acid I issued in the Et agricultural method can be combined Mohe {合 5 合 界 自 合 塩 L 本 ， 本} type prescription, powdered and powdered 60 geese. Huaka H Hua Dannong's things, (1 fixed, refined when used-3 refined agent The new intensive fine sand is dispatched and divided into stable DL pastes, sugar pastes, NX pastes, and pastes, pastes, made-to-make species, agent-dissolved ring emulsion ring, ring ring, water ring, P ring, and control. The use of powder and the use of cards to kill the 'I' and the carbon to kill this pair of live hair are divided into: There are new and blessing calcium and blessing L 'and blessing Bairu, so that the medicine is used Acid content, content / acid content / agricultural content /, pesticides that are harmful to all agricultural properties such as ① ② ③ ④ ⑤ Yao'an Gaohuo: ① (please read the precautions on the back before filling out this page) _ gardens, vegetable fields, fruit trees Huan et al., M pesticide formulation, every 10g, the size of the paper Printed in China National Standard (CNS) Α4 specification (21〇297297 mm) 2 1 B7 B7 Printed by the employee consumer cooperative of the Central Bureau of Standards of the Ministry of Economy V. Invention description (22) Generally use about 1 ~ 5 kg, preferably 3 ~ 4 kg. For every 10 acres of active pesticide ingredients, generally use about 2.5 to 2 500 g, if it is about 7.5 to 200 g, it is more ideal. ② When the dosage form is granules, you can Use as is. Generally, paddy fields, tea gardens, vegetable fields, orchards, etc., based on pesticide preparations, generally use about 0.5 to 5 kg per 10 acres, and more preferably 1 to 4 kg. Μ Pesticide Active Ingredients For every 10 acres, about 2.5 to 500 grams are generally used, and if about 5 to 100 grams are used, it is more ideal. ③ When the dosage form is water solvent, water and agent, it can be dissolved in water when it is used. Use after dilution. Although the dilution is not particularly limited, it is usually about 500 ~ 2000 times diluted, if it is about 1000 ~ 2000 times diluted (about 1g / 1000ml ~ 1g / 2000ml) is more ideal. The dispersion of this dilution The amount depends on the type of pesticide active ingredient, the target pest, and the time of application The period, application site, application method, etc. vary. Fields such as paddy fields, tea gardens, or vegetable fields and orchards, etc., generally spread 500-15000 liters per 1 hectare, if they are scattered about 1000-1000 liters Ideal. It is more ideal if about 200 to 7000 liters are scattered.. The inclusion body of Nitta Bira with cyclodextrin compound is also stipulated. The pesticide containing this inclusion body itself The preparation can also be manufactured according to the method described above to make a stable pesticide preparation. In addition, the present invention is intended to provide novel water-soluble pesticide granules which can inhibit the decomposition of active ingredients of water-soluble pesticides such as Nitta Bira. In particular, Μ will not compromise the water solubility of water-soluble granules. The paper size is applicable to the Chinese National Standard (CNS) Λ4 specification (210X297mm) I ----------(please first Read the precautions on the back and fill in this page) :: ^ 1- 22 316840 A7 B7 Fifth, the characteristics of the invention (2 3), and the purpose of mentioning the qualitative granules for the preservation of the active ingredients of water-soluble pesticides. The inventors of the present invention combined Nitinbila with cyclodextrin compounds and found that when wet granulation was carried out, stable Nitianbila water-soluble pesticide particles could be obtained. The present inventors further found that, in addition to Nitian Bila M, other water-soluble agricultural active ingredients can also be obtained with a similar water-soluble pesticide granule, and completed the following invention. That is, the present invention It is further provided as follows: (42) A water-soluble granule characterized by containing water-soluble pesticide active ingredients and cyclodextrin compounds. (43) The water-soluble granules as described in item (42) further contain water-soluble weakly alkaline substances. (44) The water-soluble granules as described in item (42) or (43), the water-soluble pesticide active ingredient is a water-soluble pesticide active at 20 g and a solubility in water of 0.01 g / ml M Ingredients. (45) The water-soluble granules as described in item (42) or (43), the active ingredient of the water-soluble pesticide is Nitabira. (46) Provide the water-soluble granules as described in the item (42), characterized in that for the total amount of water-soluble granules, the water-soluble pesticide active ingredient accounts for about 5 to 95% by weight, and cyclodextrin accounts for about 1 to 94% by weight %By. (4 7) The water-soluble granules as described in item (4 2) or (4 3), the water-soluble pesticide active ingredients are from Pedandan acid, Nitian Bila, allethrin , Hao Sheng, ESP (oxydeprofos) 2 3 ^, loaded ----: ---: order-'! --- ^ ^ •, * (please read the notes on the back before filling in This page) The paper standard printed by the Staff Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs conforms to the Chinese National Standard (CNS) A4 specifications (210X297 Gongcheng) A7 B7 V. Description of invention (24), rice pine, trichloroform, Vitaloxin A. One or two kinds of water-soluble pesticide active ingredients selected from M in the combined group of Daji and Birafosone. (48) The water-soluble granules described in items (42) to (47), wherein the tridextrin compound is α-cyclodextrin, / 3-cyclodextrin, 7-cyclodextrin or these rings Compounds or mixtures of these compounds that have been chemically modified by dextrin. (49) The water-soluble granules as described in items (42) to (47), whose cyclodextrin compounds are selected from the following compound combinations of one or two mixtures on M: Ministry of Economic Affairs Central Standards Bureau staff consumer cooperatives print α-cyclodextrin, / 3-cyclodextrin, 7-cyclodextrin, (1,2 or 3) -methyl-α-cyclodextrin, (1,2 or 3)- Methyl- / 3-cyclodextrin, (1, 2 or 3) -methyl-7-cyclopentin, hydroxypropyl-O (-cyclodextrin, hydroxypropyl- / 3-cyclodextrin, hydroxy Propyl-7-cyclodextrin, glucosyl-α-cyclodextrin, glucosyl- / 3-cyclopentin, glucosyl-7-cyclodextrin, maltosyl-α-cyclopentin, maltose Base- / 3-cyclodextrin, maltosyl-7-cyclodextrin, poly-α-cyclodextrin, poly-cyclodextrin, poly-7-cyclodextrin., (50) as item (42) ~ The water-soluble granule according to item (47), wherein the cyclodextrin compound is a mixture of α-cyclodextrin, / 3-cyclodextrin, 7-cyclodextrin or maltosyl-α-cyclodextrin Individuals. (5 1) The water-soluble granules described in items (4 2) to (4 7), whose cyclodextrin compound is dodolin-Ρ (trade name Asahi) -Μ trade name Ocean Fisheries Co., Ltd.) by Corporation), or the beneficial interest. This paper scale is applicable to the Chinese National Standard (CNS) Α4 specification (210X297mm) (please read the precautions on the back before filling in this page) 24 A7 __B7_ V. Description of the invention (25) (5 2) as in (4 3) The water-soluble granule described in the item has a water-soluble weakly alkaline substance at 20 ° C and a solubility in water of about 0.05 g / ml, and at 25 scoops, the p Η value of the aqueous solution is about 7. 0 ~ 9. 0 water-soluble weak substances. (53) The water-soluble granules as described in item (52), the water-soluble weakly alkaline substance is in 2010, the solubility in water is about 0.05 g / ml, and at 25¾, the pH of the aqueous solution is about 7.0 ~ 9.0 water-soluble weakly alkaline substance, and it is one or more of M selected from the group consisting of sodium thiosulfate, dihydrogen phosphate, sodium acetate, sodium carbonate and sodium bicarbonate. (54) The water-soluble granules described in items (42) to (53) further contain a surfactant. (5 5) The water-soluble granule according to item (5 4), wherein the surfactant is a nonionic surfactant having an HLB value of about 9 to 12. (5 6) The water-soluble granules described in item (5 5), wherein the nonionic surfactant with an HL B value of about 9 to 12 is polyoxyethylene nonylphenyl ether or vaporized ethylene and oxidation Block copolymer of propylene. Printed by the Employee Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs (please read the precautions on the back before filling in this page) (57) The water-soluble granules described in item (43) are characterized by: , Containing a water-soluble weakly alkaline substance "approximately 5 to 90% by weight. (5 8) The water-soluble granules described in item (5 4) are characterized in that they contain interfacial activity for the entire amount of water-soluble granules. The agent is about 0.05 ~ 90% by weight. The water-soluble pesticide active ingredient in the water-soluble granules of the present invention has a solubility in water of about 0.01 g / ml or more at 20 ° C, which is more ideal for paper size Applicable to the Chinese National Standard (CNS) A4 specification (210X297 mm) 25 A7 B7 printed by the Employees ’Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 5. Description of the invention (26) Pesticide active ingredients of more than about 0.1 g / ml. This pesticide activity The ingredients are all pesticide active ingredients such as insecticides, fungicides, herbicides, etc. In the water-soluble granules of the present invention, these water-soluble pesticide active ingredients can be > λ used One or two kinds of K. The water-soluble pesticide active ingredients used in the water-soluble granules of the present invention are specifically exemplified as follows: Solubility (water) Melting point 1C — Insecticide — Pedandan acid 200 g / L 1 79 18 1 Nitin Bila> 2 0 0 g / l 84 85 Alenin 5 0 0 g / l solution is better than 6 5 0 g / l 9 1 92 Oxydox * Dissolved solution Pometha Pine 4 0 0 0 g / Liter 46 48 three atmospheres imitation 1 5 4 g / liter (25 X:) 83 84 — fungicide — vitamin A easily soluble 1 35 — herbicide — dao 7 0 0 g / liter bifosone > 1 0 0 0 g / liter of the water-soluble pesticide active ingredients described above 1 by Pedandan acid acid salt better than Nitian Bila and Vida Huisu A etc. In the group, one of the two or two types of vx is more ideal, and Nitian Bila is the most ideal. The content of the water-soluble pesticide active ingredient used in the water-soluble granules of the present invention is generally the total amount of granules. About 5 ~ 9 5 wt%, about (please read the precautions on the back and then fill out this page) 26 This paper size is applicable to China National Standard (CNS) A4 specification (210X297mm) Printed by the Employee Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs Preparation A7 B7 5. Description of the invention (27) 5 ~ 80% by weight is more ideal. The content of the cyclodextrin compound used in the water-soluble granules of the present invention is generally about 1 to 94% by weight, more preferably about 2 to 90% by weight, based on the total amount of granules. The water-soluble granules of the present invention may also contain water-soluble weakly alkaline substances, surfactants, pigments, binders, ultraviolet absorbers and other water-soluble auxiliary agents. As a water-soluble weakly alkaline substance, although it is not particularly limited, but Μ 2 20, its solubility in water is about 0.05 g / ml or more, and at 25 it, the ρ Η value of the aqueous solution is about 7. 0 ~ 9. 0 is the most ideal. Specifically, for example, one or two kinds of K selected from the group consisting of sodium thiosulfate, disodium hydrogen phosphate, sodium acetate, sodium carbonate, and bicarbonate are used. The grade of this water-soluble weakly alkaline substance is for the Japanese Pharmacopoeia, for industrial use, for food additives, etc., and it can be used regardless of whether it contains crystal water. When the water-soluble granules of the present invention are mixed with a water-soluble weakly alkaline substance, it is best to avoid the use of water-soluble pesticide active ingredients that are unstable under alkaline conditions, such as pedan acid and the like. The content of water-soluble supplements other than these K in water-soluble granules is generally about 5 to 90% by weight, preferably about 30 to 90% by weight, for the total amount of water-soluble granules. % Range, the surfactant is usually about 0.05 ~ 5% by weight, preferably about 1.0 ~ 3.0% by weight, the pigment is usually about 0.01 ~ 0.5% by weight, preferably about 0.01 ~ 0.1% by weight The binder is usually in the range of about 0.5 ~ 10.0% by weight, preferably in the range of about 2.0 ~ 7.0. The water-soluble granules of the present invention can be applied to the Chinese National Standard (CNS) A4 specifications (210 X 297 mm) in accordance with the general water-soluble granules and the paper size. 27 ---------- ϊ ^ .-- (Please read the precautions on the back before filling in this page) * 'A7 B7 printed by the employee consumer cooperative of the Central Bureau of Standards of the Ministry of Economy V. Description of invention (28) Manufactured by the manufacturing method of the agent, for example: spray drying method or Manufactured by wet extrusion granulation method. When the spray drying method is used, 100 parts by weight of the preparation solid is dissolved by adding about 50 to 1000 parts by weight of water, and the aqueous solution is spray dried, and the powder can be dried to obtain a water-soluble granule. Specifically, the water-soluble pesticide active ingredient, the ring lake essence compound, surfactants and other water-soluble supplements are added if necessary, and it is dissolved with a sufficiently soluble amount of water. Water-soluble granules are obtained. Alternatively, the active ingredients of water-soluble pesticides and cyclodextrin compounds may be dissolved in an appropriate amount of water, spray-dried and then mixed with surfactants and other water solvent supplements. In addition, this mist-dried product can also be granulated by wet extrusion as described below, and the resulting particles have a particle size in the range of about 0.05 ~ 1.0 mm, if it is in the range of about 0.1 ~ 0.5 mm, Is the most ideal. When wet extruding granulation is used, 100 parts by weight of the solids of the preparation is made with about 1 to 10 parts by weight, preferably about 2 to 5 parts by weight of water. Specifically, other water solvent auxiliary agents such as water-soluble pesticide active ingredients, cyclodextrin compounds, and surfactants added if necessary are mixed uniformly with a mixer or the like. At this time, if the particle size of the solid component is too large to mix uniformly, firstly, coarsely pulverized M can be added to make an appropriate powder under 100 μM, and M can be easily mixed. Add an appropriate amount of water to this mixture and process it with a mixer until it is suitable for post-process extrusion granulation. After this mixture is granulated by general extrusion granulation, it is dried. If necessary, the granulated material is granulated to obtain the desired water-soluble granules. The size is adjusted to the point where it cannot pass through the sieve of 300 μm mesh, but can pass through the sieve range of 1 700 μm mesh. For the obtained pellets, the paper size of this paper is applicable to the Chinese National Standard (CNS) A4 specification (210X297mm) 28 ί —Package-(please read the precautions on the back before filling this page) · '* Order A7 B7 5. Description of the invention (29) It is in the range of about 0.5 to 10.00 mm, and it is most ideal if it is in the range of about 0.5 to 5.00 mm. In addition, the bulk density of such particles is in the range of about 0.1 to 1.2 g / ml, and the most suitable if it is in the range of about 0.5 to 1.0 ml. In this way, the obtained water-soluble granules of the present invention are completely harmless to plants and harmless to humans or animals during or after application, and can be used safely. In addition, the water-soluble granules of the present invention have the characteristics of water-soluble granules, do not impair the solubility in water, and can improve the storage stability of the water-soluble pesticide active ingredient. [Embodiments of the invention] Examples, comparative examples, and test examples are described below, and the present invention will be described in detail. But ‘yes, the invention is not limited to the examples described below. The "%" and "parts" used heretofore, unless otherwise specified, refer to "% by weight" and "parts by weight". Guan Shi 1 Printed 20 parts of Nitta Bira and Dodolin-P80 parts by the Staff Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs, dissolved with 400 parts of water, spray-dried, and obtained the cyclodextrin inclusion of Nita Bila Thing. Mix Sutai, Xinkajie HX-360 and the Japanese Pharmacopoeia Sodium Bicarbonate, after crushing, add the cyclodextrin inclusions of Nitta Bira, mix well to obtain the following formula water and agent. % By weight Nitabira / Dodrin-P (20:80) 2 5 Free Sutai 50 New Card World NX-360 8 29 (Please read the precautions on the back before filling in this page) This paper size is applicable to Chinese countries Standard (CNS) A4 specification (210X297 mm) Printed by the Staff Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs ^ 16840 A7 B7 V. Description of the invention (3 0) The Japanese Pharmacy prescription bicarbonate is used for the rest of the night. Example 2 Nita ratio Pull 20 parts and Dodrin-P 8; 0 parts, dissolve with 40 parts of water f Spray dry f to obtain cyclodextrin inclusions of Nitta Bila 0 After demon, mix the raw materials described in the following recipes> ; Get the following formula of water and agent 0% by weight Nitta Bila / Dodrine-P (20:80) 25 Pedan 塩 酸 塩 50 Japanese Medicines Pharmacological lactose remaining m. Example 3 20 parts of Nitian Bila And 80 parts of Dodolin-P, after dissolving with 400 parts of water, 唔 m 干 丰 t get Nitta ratio Cyclodextrin inclusions that were pulled 〇Folly pine N was blessed to be% Matsubo 5 1 15 'New card world BX-C and water and agent were mixed with sodium bicarbonate 9 After crushing * Added Nitin Bila ’s cyclodextrin Fine inclusions, mix evenly »Get the following formula water and agent 〇% by weight Nitta Bila / Dodolin-P (20: 80) 25 Welfare Pine 30 Fusong De 20 Song Bo 5 1 15 10 New Card World BX -C 4 Calcium carbonate for water additives The rest (please read the precautions on the back before filling in this page)% 20 parts of Nitinibira and 80 parts of Dodolin-P, after dissolving 400 parts with water, this paper The standard is applicable to the Chinese National Standard (CNS) A4 specification (210X297 mm) 30 B7 Printed by the Employee Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs V. Description of the invention (3 1) Spray drying 9 Get the cyclodextrin inclusion of Nitta Bira 0 Yaohou will record the following recipe After the raw materials are mixed uniformly> crushed to obtain the powder DL 〇% by weight Nitta Bila / Dodolin-P (20: 80) 1. 25 Fuli Song 2 · 00 Fu killed 1.50 IP solvent 0. 20 new card Jie EP-70P 2 .00 White carbon 1. 00 Desanon L 0. 05 DL powder for calcium carbonate and the rest of Shao Example 5 20 parts of Nitta Bira and 80 parts of Dodolin-P 80, after dissolving with 400 parts of water > Spray drying 1 Nitrabyl cyclodextrin inclusions were obtained. Then mix the raw materials described in the following recipes evenly and then f crush them to obtain powder DL 0% by weight Hou Tian Bila / Dodolin-P (20: 80) 1. 25 Fusong pine 2. 00 Fu kill 1. 50 Pedan dan acid salt 2. 0 0 P AP additives 0. 15 IP solvent 0. 20 New card world EP -7 0P 2. 00 white carbon 1. 00 This paper scale is applicable to China National Standards (CNS) A4 specifications (21 OX 297 mm) A7 __B7_, V. Description of the invention (3 2) · Desanon L 0.05 DL powder for clay and other powders When the pus is β 20% by Nitta Bira and 80 parts by Dodolin-Ρ, 400 parts by water After that, spray drying to obtain the cyclodextrin inclusion of Nitian Bila. Then mix the raw materials described in the following recipes evenly and pulverize them to obtain a powder DL °% by weight Nitian Bila / Dodolin-Ρ (20:80) 1.25 Fusong 2.00 Fusong 1.50 Fusong 3.00 I Ρmedicine 0.20 New card world ΕΡ-70Ρ 2.00 White carbon 1 〇〇 得 沙 农 L 〇.05 5 DL powder for calcium carbonate remaining oil oil example 7 Ministry of Economic Affairs Central Standards Bureau employee consumption cooperative printed Nitta Bira 20 80 parts of Dodolin-P, dissolved in 40 parts of water, spray-dried to obtain a cyclodextrin inclusion compound of Nitin Bila. Then, after mixing all the raw materials described in the following recipes uniformly, add 10 ~ 15 parts of water to the preparation and knead it, then extruded and granulated through a 1 mm sieve. After the granules were dried, the granules were sized with 10 meshes and 48 meshes to obtain granules. Weight% 5.00 (Please read the precautions on the back before filling in this page) Nitta Bila / Dodlin-P (2 0: 8 0) This paper scale is applicable to the Chinese National Standard (CNS) A4 specification (210X297 mm) 32 A7 B7 Printed by the Employees ’Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economy V. Description of the invention (3 3) Pedandan acid acid 4.00 85% phosphoric acid; 2.00 New card world EP-70P 2.00 Dextrin ND-S 7.00 Clay for granules remaining hh Age Example 1 Nitinbila / Dodorin-P (2 0: 8 0) 25% of Example 1 was replaced by Nitinpira 5%, as Comparative Example 1. hh Comparative Example 2 Nitinbila / Dodorin-P (2 0: 8 0) 25% of Example 2 was replaced with Nitinpira 5%, as Comparative Example 2. Example 3 of hh age The nitinbila / dodrine-P (2 0: 8 0) 25% of example 3 was replaced with nitinpira 5% as Comparative Example 3. Test Example 1 5 grams of the preparations produced in Examples 1 to 5 and Comparative Examples 1 to 5 were placed in glass bottles, sealed, and allowed to stand for 3 months in a constant temperature bath at 40 ° C, followed by high performance liquid chromatography Method to determine the content of Nitian Bila, the following formula is used to calculate the residual rate, the results are shown in Table 1. The residual rate of Nitta Bira (%) = (content / initial content) x 100. The paper size is in accordance with the Chinese National Standard (CNS) A4 specification (210X297 mm) — —————- I:-·· I 、 ^^! ····················-0¾ if * · (please read the precautions on the back and then fill in this page) 33 316840 a? B7 5. Description of the invention (3 4) 〔Table 1〕 Test example: Residual rate of Nitin Bila% Example 1 97.2 Example 2 95.7 Example 3 99.8 Example 4 97.5 Example 5 9 4.7 Comparative Example 1 8.2 Comparative Example 2 4.4 Comparative Example 3 65.1 Central Ministry of Economic Affairs Printed by the Bureau of Standards and Staff ’s Consumer Cooperative (please read the precautions on the back before filling in this page). From Table 1, it is known that Nitta Bila Roo is packaged with cyclodextrin compounds. In each pesticide formulation, the residual rate is Leaping rise. Example of vial 8 Nineta Bira 10 parts and Dodrin-P 90 parts, dissolved with 400 parts of water, this paper scale is applicable to the Chinese National Standard (CNS) A4 specification (210 X 297 mm) 34 Economy Printed 316840 A7 B7 by the Employees ’Cooperative of the Central Standards Bureau of the Ministry of Foreign Affairs 5. Description of the invention (35) The aqueous solution is solid-particulated with a spray drier (Okawahara Chemical Machinery, L-8) to obtain 10% water solubility containing Nitta Bira Granules. Example 9 90 parts of Dodolin-P in Example 1 were replaced with 90 parts of Isopril-P and spray-dried according to the procedure of Example 1 to obtain a water-soluble granule containing 10% of Nitenbira. Ninglun Example 1 0 90 parts of Dodolin-P in Example 1 were replaced with 30 parts of Dodolin-P and 60 parts of sodium acetate, followed by the steps of Example 1 and dried by fogging to obtain a product containing nidenbyl 1 0% water-soluble granules. Guanlun Example 1 1 I · Nitabira 10 parts, surfactant Xinbao PE-64 1.0 parts, pigment Anin Green G 0.15 parts, Dodrine-P 3.0 parts, sodium bicarbonate 85.85 parts after fully mixed, add Mix 4 parts of water with a kneading machine (Kikusui Co., Ltd., K Μ-1.5). This kneaded material was granulated into cylindrical granules by using a 0.8 mm diameter sieve through an extruding granulator (Kikusui Co., Ltd., R G-5 Μ). The obtained granules were dried at 60 υ for 1 hour to obtain a water-soluble granule containing 10% of Nitian Bila Ο g. Example 1 2 40 parts of Nitin Bila, 60 parts of Dodolin-P, 400 The water is dissolved, and the aqueous solution is solid-granulated by a spray-drying device (Ogawara Chemical Machinery, L-8) to obtain a water-soluble granule containing 40% of Nitta Bira. 25 parts of this water-soluble granule, 1.0 parts of the surfactant Xinbao PE-64, 0.15 parts of the pigment Anin Green G, 7 3 .85 parts of sodium bicarbonate, and 4 parts of water are added, (please first Read the precautions on the back and fill in this tile).

, 1T " This paper scale is applicable to the Chinese National Standard (CNS) Α4 specification (210X297 gong) 35 A7 B7 printed by the Employee Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs V. Invention description (36) Kneading machine (Kikusui, K M -1. 5) Mix it up. Then, follow the steps of Example 4 Example 4 to obtain granules »to obtain a water-soluble granule containing 10% of Nitenbira. Comparative Example 4 90 parts of Dodolin-P of Example 8 were replaced with 90 parts of lactose, according to The procedure of Example 8 was spray-dried to obtain water-soluble granules containing 10% of Nitenbira 0 Comparative Example 5 Dodrine-P of Example 11 3.0 parts sodium bicarbonate 85.8 5 parts sucrose 5 . 5 parts', lactose 83. 85 parts instead of 9 according to the example 11 of the Zhao Example 1 to extract the granules »to obtain water-soluble granules containing 10% of Nitian Bila. Test Example 2 The water-soluble granules produced in Examples 8 to 12 and Comparative Examples 4 and 5 were taken and allowed to stand in a thermostat at 40 | Ό for 3 months. The content of nitinpira was determined by high-performance liquid chromatography 9 Calculate the residual rate »The results are shown in Table 2 0

Hi III n-'II 1 (Please read the precautions on the back before filling in this page) τ' order 36 This paper size is applicable to the Chinese National Standard (CNS) Α4 specifications (210 X 297 mm) 3 to 40 Α7 Β7 5. Description of the invention (37) [Table 2] Residual rate% of Nitinpira Test Example Example 8 98.9 Example 10 99.1 Example 1 1 98.7 Example 12 98.3 Comparative Example 4 9 1.1 Comparative Example 5 90.3 • ^ ▲- (Please read the precautions on the back before filling out this page) Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs, as shown in Table 2, the water-soluble granules of the present invention, even if they are single doses, are the residues of Nitta Bira Compared with the water-soluble granules containing K-Nitabira, the rate is obviously much higher. From this, it can be seen that the water-soluble granules of the present invention can stabilize Nitabira. Example 1 3 20 parts of Nitabira and 80 parts of Dodolin-P are dissolved in 400 parts of water, spray-dried to obtain a cyclodextrin inclusion of Nitabira, and then each After the raw materials are evenly mixed, pulverized to obtain a powder. This paper scale is applicable to China National Standard (CNS) Α4 specification (210X297 mm) 37 V. Description of invention (3 8) A7 B7 Printed by Employee Consumer Cooperative of Central Bureau of Standards, Ministry of Economic Affairs

Nitta Bila / Dodrine-P (2 0: 8 0) Pedandan Acid PAP Rib Replenisher IP Solvent New Card World EP-70P Clay Window for White Carbon DL Powder Example 1 4 K Example 1 3 of 3 In the same way, Nitta Bila / Dodrin-P (20:80) Pedandan Acid Vida Huisu A PAP Supplement IP Solvent New Card World EP-70P White Carbon DL Powder Clay Dunlun Example 1 5 Μ In the same manner as in Example 13, Nitin Bila / Dodrine-P (2 0: 8 0) Vidacrosin A wt% 1.25 2.0 0.15 The remainder was powdered DL from the following formula. Weight% 1.25 2 .0 0.3 0.15 0.2 2.0 1.0 The rest The powder D L was obtained from the following formula. Weight% 1.25 (please read the precautions on the back before filling in this page) Packing · .I order paper size is applicable to China National Standard (CNS) A4 specifications (210X297mm) 38.05 A7 B7 V. Invention description (3 9 ) IP solvent New Card World EP-70P white carbon butyl p-hydroxybenzoate NP-1 1 0 Clay for DL powder 15 · 0 Calcium carbonate for DL powder &

Example 1 R

ΜThe same method as in Example 13 to obtain the powder DL weight% from the following formula (please read the precautions on the back before filling in this page) The Ministry of Economic Affairs Central Standards Bureau Employee Consumer Cooperative Printed Nitta Bila / Dodlin-Ρ ( 2 0: 8 0) Pedandan acid Vidaoxin A Fusha to get PAP. Rib filler IP solvent New card world EP-70P white carbon DL powder for clay glen Example 1 7 The same method as the real cell Example 13 , Prepared by the following formula: Nitian Bila / Dodolin-M20: 80) Fuli Song 1 25 15 The rest of the powder weight agent DL. Amount% • 25.0 39 This paper scale applies the Chinese National Standard (CNS) A4 specification (21〇X 297 mm)

Si6S40 A7 B7 Fifth, the description of the invention (40) Fudeweidahuisu A IP solvent New card world EP-70P white carbon is Shannon L butyl p-hydroxybenzoate NP-1 1 0 DL powder for clay DL powder Calcium carbonate 0.2 2.0 1.0 0.05 0.05 0.1 15.0 The rest of the Ministry of Economic Affairs Central Standards Bureau employee consumer cooperative printed the same method as in Example 1 3, the powder DL was prepared from the following formula by weight% Nitta Bila / Dodolin-P ( 20:80) 1.25 Fusong Pine 2.0 Fushade 1.5 Vidacrosin A 0.3 Pedansulfuric Acid 2.0 PAP Supplement 0.15 IP Solvent 0.2 New Card World EP-70P 2.0 White Carbon Desanone L DL Powder Clay 05 Others- -------- f 、 装 ---- N--: ordered ^ ---- j bismuth-* < (please read the precautions on the back first and then fill out this page) This paper wave scale is suitable for Chinese countries Standard (CNS) A4 specification (210X297 mm) 40 B7 5. Description of invention On) Window example 1 9 According to the same method as in example 13, powder DL was prepared from the following formula. Weight% Printed by the Ministry of Economic Affairs, Central Bureau of Standards, Employee and Consumer Cooperative of Nitta Bila / Dodorin-P (20:80) Fulisong Fudeda Vidamycin A Fulazon Arabin Resin IP Solvent New Card World EP-70P White Carbon-derived Shannon L butyl p-hydroxybenzoate DL powder for clay DL powder for calcium carbonate gron example 20 Nitta Bila / Dodrine-P (20:80) Pedandan acid Vida Huixin A Welfare Pine arabic gum Fude. 25 2. 2.01.0 0.05 0.05 15.0 The remaining weight% 1.25 2.0 (Please read the precautions on the back before filling this page) This paper scale is applicable to the Chinese National Standard Falcon (CMS) A4 specification (210X297 %> 4 1 316840 A7 B7 V. Description of the invention (4 2) PAP rib filler IP solvent New card world EP-70P white carbon DL powder for clay) ife example 2 1 0.15 Printed by the remaining consumer cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs In the same manner as in Example 2 for preparing K, a hydrating agent was obtained from the following formula. % By weight Nitenbila / Dodrin-P (20:80) 25.0 Pedan citrate 5.0 Pigment Anin Green G 0.15 Industrial lactose remaining [Effect of the invention] In the present invention, it contains two kinds of pesticide active ingredients In pesticide preparations, at least one pesticide active ingredient is encapsulated with a cyclodextrin compound, which can suppress the decomposition of this pesticide active ingredient and improve storage stability. In particular, pesticide active ingredients that are contraindicated in combination can be mixed. The water-soluble granule of the present invention does not impair the solubility of water-soluble granules in water, and can also improve the storage stability of water-soluble pesticide active ingredients such as Nitta Bira. , ---------- \-(Please read the precautions on the back before filling in this page) 2 1Τ 1 The paper size is applicable to China National Standard (CNS) Α4 specification (210X297mm) 42

Claims (1)

I- 316840 ~ w Attachment 1 8β, '6 · Sai H3 Economic Lang Central Miyagi Bureau M Worker: w Li Committee: (II) Printing Disaster ~ -U, _ | J |' Patent Application for Patent Application No. 84116621 Fan Yuan Amendment (June 26, 2008, E 1) 1. A stable agricultural m system • Its special features are: In the agricultural production system containing two or more active ingredients of Xiangm with taboo Guanao, make the ft The active ingredient of more than one species-more than one C active ingredient (I)] who is included in the dextrin compound, and the dextrin compound is α-dextrin% β-cyclodextrin, cyclodextrin or some Candextrin meets certain chemically decorated compounds or mixtures of these compounds. 2. For example, the stable agricultural cracking agent in item 1 of the scope of patent application has the following two special withdrawals: (A) 1 part of agricultural active ingredient (I), inclusive of 1 20 parts of chenjing fine compounds The resulting agricultural active ingredient (I) inclusions t whose weight m is the amount of the preparation wrap 0.1 Λ -95 *; and, (B) contains pesticide active ingredients (II) other than agricultural active ingredient (I) ). The main scene is that it is made up of 1 m ~ 9 5 κ; and the active ingredients of agricultural m (I) and active ingredients of agricultural m (II) are forbidden to cooperate with taboo dwarf 0 3. China's first item of stable pesticide production m. Its agricultural active ingredients (I) S white one of the following agricultural m active ingredients-one or more than two kinds: Nitta Bira (η ite η pyra η), plus Poly (C arbary 1) plus Paul Fu La (C arb 〇fura η) > Fu La interest plus (fu Γ at hi ocarb) N保 杀 # (C arb ο su 1 fa η), Fent hi ο η >, Fula pine (fenit Γ ot hi on), Ace (acephate), Fansong (This paper size is applicable to Chinese countries Standard (CNS) A4 specification (210X 297 mm) 1 1.1 4 0 3 Η • 1 d Γ η ee 塩 e hhatlrna ttdeaaed cfi yfv ο II e ο ο azn 8 9 · 1 d / (. / (1- Songnong Lalima pine, pine, pine, pine, pine, yining, benhala, a, y, h 1 Γ yfc (/ fk, uath (ftazole (0 得 Η Η killing κ, rifafen, C, acid, danpepp Fenyisu fenverazole-free o Γ n 1 ec η eb / IV tasu-free ref / IV Songlifu t ο 11 z folapiric milmicad cad • 1 yfy Ministry of Economy Central Standard Workers: 'WJi'l Committee M Huiyin [cycloprothrin), Acrinathrin-cycloprothrin, thiabendazole, iprodione, Barcopu ( paclobutrazole), hexaconazole, defuning (Tefluthrin), common rice pine (vamidothion), tricyanoform (DEP), continent (diquat), butyl chlorpyrifos (BPMC), nanodide (eth 〇y 1) and bialaphos (bialaphos) 〇4. For example, the stable Xiangxiu formulation of patent application No. 1 whose pesticide active ingredient (I) is like one or more than two agricultural active ingredients selected from the following agricultural active ingredients: Nitian Bila, Susutai, Haosheng, Fulazon, Fuli Song, Fusode, Luoligensu A, Sancanazole and Nanolide. 5. For example, the stable agricultural preparation of item 1 of Shenzhuang Patent Fan Garden. Its stress is: Xiang_active ingredient U) is Nitta Bira. This paper scale is applicable to the Chinese National Standard (CNS) A4 specification (210X 297 Gongqing) 2 0 4 8 6 1 3. 止 充 # 补 ha I 3 Λπ: I 'i_ ^ Η Specially differentiated, sexual agent system _ The peasant farmer's type of radidine is stable, and the nimble item is 2) or ί 1 point. The country's national Fanhuoli specialty farmer please: Shen Ruru 6 wins good blessing c, who is divided, sex loose living _ rich peasant 、 Taishang Susu so as not to breed '1 «Acid acid and Hedan mixed culture to get suicide irrigation system / η 松 (I Linong pine divided into its rich agent, live Thai _ _ Sunong agricultural free type, On the top of the table to stabilize the acid species of a pill of 2 or a combination of self-selection of the first series to get the siege} killing fan (I welfare points / specializing in the use of the request of the benefit of life and happiness such as _, the ring system 0 c Farmer type Lading fchls Tian Zhini's item is 2 η or I / V 1 points, the first picture of the Fanhuoli medicine specialty farm is applied, if the 8th has a garden, it is a good thing, please apply for it. Periods such as 9 are given 0 weight ο 2 Jingshanshan-a containing the system of 0 agricultural type stability and stability 2 or ί 0y. The system of 00 type stability and stability 2 or 1- SC Contributor's Remunerative Specialized Favors Specializes in Jiejie's application as a farmer's 0 system 0 Agrotype Stabilization Item 2 or 11 , Two strokes and water-soluble granules or powders are granules _ granules of surface-dissolved water, granules of the Ministry of Economic Affairs, Central Standards Bureau, Xiao Gongyou, concubine; 3: will be printed on this paper, the scale is applicable to the Chinese National Standard (CNS ) A4 specification (210X 297 mm) 3