TW202421625A - 新穎sik抑制劑 - Google Patents
新穎sik抑制劑 Download PDFInfo
- Publication number
- TW202421625A TW202421625A TW112135857A TW112135857A TW202421625A TW 202421625 A TW202421625 A TW 202421625A TW 112135857 A TW112135857 A TW 112135857A TW 112135857 A TW112135857 A TW 112135857A TW 202421625 A TW202421625 A TW 202421625A
- Authority
- TW
- Taiwan
- Prior art keywords
- sub
- linear
- branched chain
- chain alkyl
- hydrogen
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 11
- 229910052739 hydrogen Inorganic materials 0.000 abstract 8
- 150000002431 hydrogen Chemical class 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 abstract 6
- 229910052805 deuterium Inorganic materials 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Abstract
本發明提供一種式 <b>I</b>化合物，其具有以下結構： <br/><img align="absmiddle" height="243px" width="231px" file="ed10071.JPG" alt="ed10071.JPG" img-content="jpg" orientation="portrait" inline="yes"/><br/>或其醫藥學上可接受之鹽，其中A <sub>1</sub>及A <sub>2</sub>獨立地為O或S；X選自CH <sub>2</sub>、CD <sub>2</sub>、NR <sub>3</sub>、O及S，其中R <sub>3</sub>選自氫、C <sub>1</sub>-C <sub>4</sub>直鏈或分支鏈烷基、鹵基(C <sub>1</sub>-C <sub>4</sub>)直鏈或分支鏈烷基及羥基(C <sub>1</sub>-C <sub>4</sub>)直鏈或分支鏈烷基；Y及Z選自C及N，其中當Y為C時，則Z為N，且當Y為N時，則Z為C；R <sub>1</sub>及R <sub>2</sub>獨立地選自氫、氘、C <sub>1</sub>-C <sub>4</sub>直鏈或分支鏈烷基等；或經C <sub>3</sub>-C <sub>5</sub>環烷基環取代之C <sub>1</sub>-C <sub>2</sub>烷基；或連在一起以形成C <sub>3</sub>-C <sub>6</sub>環烷基環；或若X為CH <sub>2</sub>或CD <sub>2</sub>，則R <sub>1</sub>及R <sub>2</sub>獨立地選自氫、氘、鹵素、羥基、C <sub>1</sub>-C <sub>4</sub>直鏈或分支鏈烷基等；R <sub>4</sub>選自氫、氘、氰基、鹵素、(C <sub>1</sub>-C <sub>3</sub>)烷氧基等；R <sub>5</sub>選自氫、氘、鹵素、C <sub>1</sub>-C <sub>3</sub>烷氧基、胺基、(C <sub>1</sub>-C <sub>4</sub>直鏈或分支鏈烷基)胺基等；R <sub>6</sub>選自氫、氘、鹵素、CO <sub>2</sub>R <sub>7</sub>，其中R <sub>7</sub>選自H及C <sub>1</sub>-C <sub>4</sub>直鏈或分支鏈烷基等；R <sub>8</sub>選自氫、氘及C <sub>1</sub>-C <sub>3</sub>直鏈或分支鏈烷基；R <sub>9</sub>選自C <sub>1</sub>-C <sub>3</sub>直鏈或分支鏈烷基及鹵基(C <sub>1</sub>-C <sub>3</sub>)直鏈或分支鏈烷基；及 <i>n</i>及 <i>m</i>獨立地選自0、1及2。本發明亦關於其醫藥組合物及使用其之治療方法。
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63/376,480 | 2022-09-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW202421625A true TW202421625A (zh) | 2024-06-01 |
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