TW202417460A - Ｏ－取代絲胺酸衍生物的製造方法 - Google Patents

Ｏ－取代絲胺酸衍生物的製造方法 Download PDF

Info

Publication number
TW202417460A
TW202417460A TW112128361A TW112128361A TW202417460A TW 202417460 A TW202417460 A TW 202417460A TW 112128361 A TW112128361 A TW 112128361A TW 112128361 A TW112128361 A TW 112128361A TW 202417460 A TW202417460 A TW 202417460A
Authority
TW
Taiwan
Prior art keywords
group
substituent
compound
acid
added
Prior art date
Application number
TW112128361A
Other languages
English (en)
Chinese (zh)
Inventor
野木馨介
Original Assignee
日商中外製藥股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 日商中外製藥股份有限公司 filed Critical 日商中外製藥股份有限公司
Publication of TW202417460A publication Critical patent/TW202417460A/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C07K1/026—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution by fragment condensation in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TW112128361A 2022-07-29 2023-07-28 Ｏ－取代絲胺酸衍生物的製造方法 TW202417460A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2022-121484 2022-07-29
JP2022121484 2022-07-29

Publications (1)

Publication Number Publication Date
TW202417460A true TW202417460A (zh) 2024-05-01

Family

ID=89706696

Family Applications (1)

Application Number Title Priority Date Filing Date
TW112128361A TW202417460A (zh) 2022-07-29 2023-07-28 Ｏ－取代絲胺酸衍生物的製造方法

Country Status (6)

Country Link
EP (1) EP4541787A1 (https=)
JP (1) JPWO2024024965A1 (https=)
KR (1) KR20250044666A (https=)
CN (1) CN119630640A (https=)
TW (1) TW202417460A (https=)
WO (1) WO2024024965A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4056580A4 (en) 2019-11-07 2023-12-06 Chugai Seiyaku Kabushiki Kaisha METHOD FOR PRODUCING A PEPTIDE COMPOUND COMPRISING A STERICALLY HINDERED AMINO ACID

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57159747A (en) 1981-03-27 1982-10-01 Kenji Okawa Synthesis of amino acid derivative
WO2010053050A1 (ja) 2008-11-04 2010-05-14 株式会社カネカ Ｏ－アルキルセリンおよびｎ－ベンジル－ｏ－アルキルセリンの製造法
TW202446781A (zh) 2011-12-28 2024-12-01 日商中外製藥股份有限公司 胜肽化合物之製造方法
EP3878836B1 (en) 2018-11-07 2025-07-23 Chugai Seiyaku Kabushiki Kaisha O-substituted serine derivative production method
BR112022007535A2 (pt) * 2019-11-07 2022-07-12 Chugai Pharmaceutical Co Ltd Composto peptídico cíclico tendo ação inibitória de kras
EP4083051A4 (en) 2019-12-27 2024-01-17 Chugai Seiyaku Kabushiki Kaisha METHOD FOR SYNTHESIS OF A PEPTIDE COMPOUND
WO2023023631A1 (en) * 2021-08-18 2023-02-23 Pardes Biosciences, Inc. Inhibitors of cysteine proteases and methods of use thereof

Also Published As

Publication number Publication date
WO2024024965A1 (ja) 2024-02-01
JPWO2024024965A1 (https=) 2024-02-01
CN119630640A (zh) 2025-03-14
KR20250044666A (ko) 2025-04-01
EP4541787A1 (en) 2025-04-23

Similar Documents

Publication Publication Date Title
US12312379B2 (en) Methods for producing cyclic compounds comprising N-substituted amino acid residues
KR102844018B1 (ko) N-알킬 아미노산, 및 n-알킬 아미노산을 포함하는 펩타이드의 제조 방법
KR20190095408A (ko) 7H-피롤로[2,3-d]피리미딘 유도체의 제조 방법 및 그의 합성 중간체
WO2002048157A2 (en) Imidazolidinones and their related derivatives as hepatitis c virus ns3 protease inhibitors
CN103649051A (zh) 制备包括反-7-氧代-6-(磺基氧基)-1,6-二氮杂二环[3,2,1]辛烷-2-甲酰胺的杂环化合物及其盐的方法
TW202417460A (zh) Ｏ－取代絲胺酸衍生物的製造方法
JP3254263B2 (ja) ホモキラルα−アミノアルデヒドのジアステレオ選択的な還元的ピナコールカップリング法
BG64701B1 (bg) Метод за получаване на 2-азадихидроксибицикло[2.2.1]хептаново съединение и сол на съединението и l-винена киселина
WO2020108415A1 (zh) 一种trk激酶抑制剂化合物的中间体化合物及制备方法
US20210284601A1 (en) Environmentally-friendly hydroazidation of olefins
JP4051314B2 (ja) 成長ホルモン分泌促進薬の製造方法
HK40117546A (zh) 用於生产o-取代的丝氨酸衍生物的方法
TW202432571A (zh) 二苯并富烯或二苯并富烯衍生物的去除方法
Ojima et al. Recent advances in rhodium-catalyzed cyclization reactions
JP3738225B2 (ja) 新規キラル銅触媒とそれを用いたｎ−アシル化アミノ酸誘導体の製造方法
TW201130488A (en) Pyrrole compound
Fu et al. Development of a cyclosporin A derivative with excellent anti-hepatitis C virus potency
CN105636923A (zh) 用于制备大环内酯酰胺的方法和中间体
WO2025192626A1 (ja) 環構造を有するペプチド化合物の製造方法
JPH0578290A (ja) ホモキラルα−アミノアルデヒドのジアステレオ選択的な還元的ピナコールカツプリング法
HK40096738A (zh) 包含n-取代氨基酸残基的环状化合物的制备方法
Ritsema I. Progress towards the asymmetric synthesis of alpha-methylasparagine. II. Progress towards the total synthesis of diazonamide A
WO2002022549A1 (en) Process for the removal of nitrobenzenesulfonyl
HK40120616A (zh) 用於生产含有n-取代氨基酸残基的环肽化合物的方法
CN121941697A (zh) 用于使用两种或更多种添加剂生产肽化合物的方法