TW202387B - - Google Patents
Download PDFInfo
- Publication number
- TW202387B TW202387B TW081103962A TW81103962A TW202387B TW 202387 B TW202387 B TW 202387B TW 081103962 A TW081103962 A TW 081103962A TW 81103962 A TW81103962 A TW 81103962A TW 202387 B TW202387 B TW 202387B
- Authority
- TW
- Taiwan
- Prior art keywords
- day
- heartburn
- placebo
- night
- treatment
- Prior art date
Links
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims description 40
- 208000000689 peptic esophagitis Diseases 0.000 claims description 32
- 238000011282 treatment Methods 0.000 claims description 31
- 239000003814 drug Substances 0.000 claims description 17
- 229940079593 drug Drugs 0.000 claims description 12
- 150000001875 compounds Chemical class 0.000 claims description 3
- 239000004480 active ingredient Substances 0.000 claims 1
- SGXXNSQHWDMGGP-IZZDOVSWSA-N nizatidine Chemical compound [O-][N+](=O)\C=C(/NC)NCCSCC1=CSC(CN(C)C)=N1 SGXXNSQHWDMGGP-IZZDOVSWSA-N 0.000 claims 1
- 229960004872 nizatidine Drugs 0.000 claims 1
- 238000012856 packing Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 201000006549 dyspepsia Diseases 0.000 description 51
- 208000024798 heartburn Diseases 0.000 description 51
- 239000000902 placebo Substances 0.000 description 37
- 229940068196 placebo Drugs 0.000 description 36
- 208000024891 symptom Diseases 0.000 description 26
- 238000012360 testing method Methods 0.000 description 21
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 18
- 230000000694 effects Effects 0.000 description 17
- 238000000034 method Methods 0.000 description 14
- 238000004458 analytical method Methods 0.000 description 13
- 206010030216 Oesophagitis Diseases 0.000 description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 12
- 208000006881 esophagitis Diseases 0.000 description 12
- 239000003795 chemical substances by application Substances 0.000 description 11
- 201000010099 disease Diseases 0.000 description 10
- 238000001839 endoscopy Methods 0.000 description 10
- 229940069428 antacid Drugs 0.000 description 9
- 239000003159 antacid agent Substances 0.000 description 9
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 9
- 238000010992 reflux Methods 0.000 description 9
- 208000025865 Ulcer Diseases 0.000 description 8
- 231100000397 ulcer Toxicity 0.000 description 8
- 230000002079 cooperative effect Effects 0.000 description 7
- 210000003238 esophagus Anatomy 0.000 description 7
- 230000001186 cumulative effect Effects 0.000 description 6
- 230000002354 daily effect Effects 0.000 description 6
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 5
- 208000002193 Pain Diseases 0.000 description 5
- 230000001458 anti-acid effect Effects 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 210000002784 stomach Anatomy 0.000 description 5
- 206010015150 Erythema Diseases 0.000 description 4
- 235000005911 diet Nutrition 0.000 description 4
- 230000037213 diet Effects 0.000 description 4
- 231100000321 erythema Toxicity 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 3
- 241000218206 Ranunculus Species 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 208000007107 Stomach Ulcer Diseases 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 229940045098 gelusil Drugs 0.000 description 3
- 210000000111 lower esophageal sphincter Anatomy 0.000 description 3
- 150000003180 prostaglandins Chemical class 0.000 description 3
- 229940125725 tranquilizer Drugs 0.000 description 3
- 239000003204 tranquilizing agent Substances 0.000 description 3
- 230000002936 tranquilizing effect Effects 0.000 description 3
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 2
- 208000007882 Gastritis Diseases 0.000 description 2
- 235000006679 Mentha X verticillata Nutrition 0.000 description 2
- 235000002899 Mentha suaveolens Nutrition 0.000 description 2
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 206010039509 Scab Diseases 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000001476 alcoholic effect Effects 0.000 description 2
- NZUPCNDJBJXXRF-UHFFFAOYSA-O bethanechol Chemical compound C[N+](C)(C)CC(C)OC(N)=O NZUPCNDJBJXXRF-UHFFFAOYSA-O 0.000 description 2
- 229960000910 bethanechol Drugs 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 238000002483 medication Methods 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 229960005489 paracetamol Drugs 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 description 1
- LRDIEHDJWYRVPT-UHFFFAOYSA-N 4-amino-5-hydroxynaphthalene-1-sulfonic acid Chemical compound C1=CC(O)=C2C(N)=CC=C(S(O)(=O)=O)C2=C1 LRDIEHDJWYRVPT-UHFFFAOYSA-N 0.000 description 1
- KKADPXVIOXHVKN-UHFFFAOYSA-N 4-hydroxyphenylpyruvic acid Chemical compound OC(=O)C(=O)CC1=CC=C(O)C=C1 KKADPXVIOXHVKN-UHFFFAOYSA-N 0.000 description 1
- 208000007848 Alcoholism Diseases 0.000 description 1
- 241000272525 Anas platyrhynchos Species 0.000 description 1
- ROFVEXUMMXZLPA-UHFFFAOYSA-N Bipyridyl Chemical group N1=CC=CC=C1C1=CC=CC=N1 ROFVEXUMMXZLPA-UHFFFAOYSA-N 0.000 description 1
- 241000237519 Bivalvia Species 0.000 description 1
- 208000031229 Cardiomyopathies Diseases 0.000 description 1
- 241000282994 Cervidae Species 0.000 description 1
- 206010008479 Chest Pain Diseases 0.000 description 1
- 241001517307 Chysis Species 0.000 description 1
- 206010013654 Drug abuse Diseases 0.000 description 1
- 206010013952 Dysphonia Diseases 0.000 description 1
- 229910052692 Dysprosium Inorganic materials 0.000 description 1
- 208000007217 Esophageal Stenosis Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 208000000857 Hepatic Insufficiency Diseases 0.000 description 1
- 102000003710 Histamine H2 Receptors Human genes 0.000 description 1
- 108090000050 Histamine H2 Receptors Proteins 0.000 description 1
- 208000010473 Hoarseness Diseases 0.000 description 1
- 208000019693 Lung disease Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241000237852 Mollusca Species 0.000 description 1
- 206010030194 Oesophageal stenosis Diseases 0.000 description 1
- 208000025157 Oral disease Diseases 0.000 description 1
- 208000031481 Pathologic Constriction Diseases 0.000 description 1
- 238000001358 Pearson's chi-squared test Methods 0.000 description 1
- 241000287462 Phalacrocorax carbo Species 0.000 description 1
- 206010035669 Pneumonia aspiration Diseases 0.000 description 1
- 201000000660 Pyloric Stenosis Diseases 0.000 description 1
- WINXNKPZLFISPD-UHFFFAOYSA-M Saccharin sodium Chemical compound [Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 WINXNKPZLFISPD-UHFFFAOYSA-M 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 241000615724 Sucra Species 0.000 description 1
- 229910052775 Thulium Inorganic materials 0.000 description 1
- 206010066901 Treatment failure Diseases 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 201000007930 alcohol dependence Diseases 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 230000001078 anti-cholinergic effect Effects 0.000 description 1
- 230000003457 anti-vomiting effect Effects 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 201000009807 aspiration pneumonia Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 208000013404 behavioral symptom Diseases 0.000 description 1
- 229940064804 betadine Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 238000009933 burial Methods 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 238000000546 chi-square test Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 235000020639 clam Nutrition 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- AMTWCFIAVKBGOD-UHFFFAOYSA-N dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane Chemical compound O=[Si]=O.CO[Si](C)(C)O[Si](C)(C)C AMTWCFIAVKBGOD-UHFFFAOYSA-N 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 229940000406 drug candidate Drugs 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- KBQHZAAAGSGFKK-UHFFFAOYSA-N dysprosium atom Chemical compound [Dy] KBQHZAAAGSGFKK-UHFFFAOYSA-N 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 239000003777 experimental drug Substances 0.000 description 1
- 239000003889 eye drop Substances 0.000 description 1
- 229940012356 eye drops Drugs 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000002309 gasification Methods 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 230000030135 gastric motility Effects 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 150000003278 haem Chemical class 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 235000021056 liquid food Nutrition 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 230000036244 malformation Effects 0.000 description 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
- 229960000282 metronidazole Drugs 0.000 description 1
- 230000002438 mitochondrial effect Effects 0.000 description 1
- 208000030194 mouth disease Diseases 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000036544 posture Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 108091006082 receptor inhibitors Proteins 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000008085 renal dysfunction Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 229940083037 simethicone Drugs 0.000 description 1
- 230000005586 smoking cessation Effects 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
- 230000036262 stenosis Effects 0.000 description 1
- 208000037804 stenosis Diseases 0.000 description 1
- 230000002966 stenotic effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- MNQYNQBOVCBZIQ-JQOFMKNESA-A sucralfate Chemical compound O[Al](O)OS(=O)(=O)O[C@@H]1[C@@H](OS(=O)(=O)O[Al](O)O)[C@H](OS(=O)(=O)O[Al](O)O)[C@@H](COS(=O)(=O)O[Al](O)O)O[C@H]1O[C@@]1(COS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)[C@H](OS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)O1 MNQYNQBOVCBZIQ-JQOFMKNESA-A 0.000 description 1
- 229960004291 sucralfate Drugs 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000003867 tiredness Effects 0.000 description 1
- 208000016255 tiredness Diseases 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70614591A | 1991-05-28 | 1991-05-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW202387B true TW202387B (enExample) | 1993-03-21 |
Family
ID=24836392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW081103962A TW202387B (enExample) | 1991-05-28 | 1992-05-21 |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0516345A1 (enExample) |
| JP (1) | JPH05148142A (enExample) |
| KR (1) | KR920021144A (enExample) |
| AU (1) | AU1721892A (enExample) |
| CA (1) | CA2069162A1 (enExample) |
| HU (1) | HU9201751D0 (enExample) |
| MX (1) | MX9202507A (enExample) |
| NO (1) | NO922019L (enExample) |
| TW (1) | TW202387B (enExample) |
| ZA (1) | ZA923711B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8071128B2 (en) | 1996-06-14 | 2011-12-06 | Kyowa Hakko Kirin Co., Ltd. | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
| US9358214B2 (en) | 2001-10-04 | 2016-06-07 | Adare Pharmaceuticals, Inc. | Timed, sustained release systems for propranolol |
| US8367111B2 (en) | 2002-12-31 | 2013-02-05 | Aptalis Pharmatech, Inc. | Extended release dosage forms of propranolol hydrochloride |
| US8747895B2 (en) | 2004-09-13 | 2014-06-10 | Aptalis Pharmatech, Inc. | Orally disintegrating tablets of atomoxetine |
| US9884014B2 (en) | 2004-10-12 | 2018-02-06 | Adare Pharmaceuticals, Inc. | Taste-masked pharmaceutical compositions |
| CA2584957C (en) | 2004-10-21 | 2015-08-25 | Eurand Pharmaceuticals Limited | Taste-masked pharmaceutical compositions with gastrosoluble pore-formers |
| US9161918B2 (en) | 2005-05-02 | 2015-10-20 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
| EP3354276B1 (en) * | 2007-11-13 | 2020-01-01 | Meritage Pharma, Inc. | Compositions for the treatment of gastrointestinal inflammation |
| EP2506836B1 (en) | 2009-12-02 | 2018-02-14 | Adare Pharmaceuticals S.R.L. | Fexofenadine microcapsules and compositions containing them |
-
1992
- 1992-05-21 TW TW081103962A patent/TW202387B/zh active
- 1992-05-21 CA CA002069162A patent/CA2069162A1/en not_active Abandoned
- 1992-05-21 EP EP92304634A patent/EP0516345A1/en not_active Withdrawn
- 1992-05-22 NO NO92922019A patent/NO922019L/no unknown
- 1992-05-22 ZA ZA923711A patent/ZA923711B/xx unknown
- 1992-05-26 HU HU9201751A patent/HU9201751D0/hu unknown
- 1992-05-26 KR KR1019920008916A patent/KR920021144A/ko not_active Withdrawn
- 1992-05-27 MX MX9202507A patent/MX9202507A/es unknown
- 1992-05-27 JP JP4134856A patent/JPH05148142A/ja not_active Withdrawn
- 1992-05-27 AU AU17218/92A patent/AU1721892A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| HU9201751D0 (en) | 1992-08-28 |
| MX9202507A (es) | 1992-11-01 |
| NO922019L (no) | 1992-11-30 |
| EP0516345A1 (en) | 1992-12-02 |
| KR920021144A (ko) | 1992-12-18 |
| ZA923711B (en) | 1993-11-22 |
| JPH05148142A (ja) | 1993-06-15 |
| AU1721892A (en) | 1992-12-03 |
| NO922019D0 (no) | 1992-05-22 |
| CA2069162A1 (en) | 1992-11-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Massad et al. | A balanced anesthesia with dexmedetomidine decreases postoperative nausea and vomiting after laparoscopic surgery | |
| Foote et al. | Treatment of overactive bladder in the older patient: pooled analysis of three phase III studies of darifenacin, an M3 selective receptor antagonist | |
| JP5442178B2 (ja) | ロキソプロフェン含有経口用組成物 | |
| CN107849021A (zh) | 治疗炎症或神经性疼痛的方法 | |
| TW202387B (enExample) | ||
| IE64953B1 (en) | Use of a composition for the manufacture of a medicament for curing the symptoms of overindulgence | |
| US10512635B2 (en) | Uses of benzimidazole derivative for nocturnal acid breakthrough | |
| RS64481B1 (sr) | Lečenje alchajmerove bolesti kod posebne populacije pacijenata | |
| Orr et al. | The efficacy of omeprazole twice daily with supplemental H2 blockade at bedtime in the suppression of nocturnal oesophageal and gastric acidity | |
| Mazumder et al. | A Review on Metformin: Clinical Significance and Side Effects. | |
| Ries et al. | Tricyclic antidepressant therapy for peptic ulcer disease | |
| JP2024524984A (ja) | 閉塞性睡眠時無呼吸を治療する方法 | |
| US20190125665A1 (en) | Suckable and/or melt-in-mouth tablet based on hyaluronic acid and chondroitin sulphate and salts thereof for use in the treatment of subpopulation of GERD patients | |
| Peura et al. | Distinguishing the impact of dexlansoprazole on heartburn vs. regurgitation in patients with gastro‐oesophageal reflux disease | |
| JP2016027058A (ja) | ロキソプロフェン含有経口用組成物６ | |
| JP7123205B2 (ja) | 経口用医薬組成物 | |
| Abbas et al. | Effect of low dose ketamine versus dexmedetomidine on gag reflex during propofol based sedation during upper gastrointestinal endoscopy. A randomized controlled study | |
| Limwatthana et al. | A randomized controlled trial comparing the efficacy and safety of pyridostigmine versus midodrine for the treatment of orthostatic hypotension in Parkinson’s disease patients | |
| Heyneman | Topical nonsteroidal antiinflammatory drugs for acute soft tissue injuries | |
| Ghomeishi et al. | A Comparison of the Sedative Effect of Dexmedetomidine and Midazolam on Patients Undergoing Gastrointestinal Endosonography Outside the Operating Room | |
| TWI837197B (zh) | 胺基甲酸酯化合物於預防、緩解或治療糖尿病周邊神經病變或化療誘發的周邊神經病變的用途 | |
| Rodríguez-Sánchez et al. | Fixed dose combination of magaldrate plus domperidone is more effective than domperidone alone in the treatment of patients with gastroesophageal reflux symptoms: a randomized double-blind study | |
| LAKSHMI et al. | Effect of 5% Dextrose Infusion on Postoperative Nausea and Vomiting in Patients undergoing Laparoscopic Cholecystectomy: A Randomised Controlled Study. | |
| Thomson et al. | Comparison of 200 mg cimetidine with multiple doses of antacid on extent and duration of rise in gastric pH in volunteers | |
| EP2537528B1 (en) | Pharmaceutical compositions containing beta- and alpha-galactosidase and their use in the treatment of gastroesophageal reflux disease |