TW202339756A - 雙環化合物用於治療疾病之用途 - Google Patents

雙環化合物用於治療疾病之用途 Download PDF

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Publication number
TW202339756A
TW202339756A TW111148490A TW111148490A TW202339756A TW 202339756 A TW202339756 A TW 202339756A TW 111148490 A TW111148490 A TW 111148490A TW 111148490 A TW111148490 A TW 111148490A TW 202339756 A TW202339756 A TW 202339756A
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TW
Taiwan
Prior art keywords
compound
group
alkyl
mmol
halo
Prior art date
Application number
TW111148490A
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English (en)
Chinese (zh)
Inventor
蓮恩 卡娃斯
凱文 雀曲
羅伯特 泰勒
傑韋爾 強斯頓
道格拉斯 保特曼
Original Assignee
美商雅斯娜製藥公司
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Application filed by 美商雅斯娜製藥公司 filed Critical 美商雅斯娜製藥公司
Publication of TW202339756A publication Critical patent/TW202339756A/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
TW111148490A 2021-12-17 2022-12-16 雙環化合物用於治療疾病之用途 TW202339756A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202163290783P 2021-12-17 2021-12-17
US63/290,783 2021-12-17
US202263312696P 2022-02-22 2022-02-22
US63/312,696 2022-02-22

Publications (1)

Publication Number Publication Date
TW202339756A true TW202339756A (zh) 2023-10-16

Family

ID=86773494

Family Applications (1)

Application Number Title Priority Date Filing Date
TW111148490A TW202339756A (zh) 2021-12-17 2022-12-16 雙環化合物用於治療疾病之用途

Country Status (11)

Country Link
US (1) US20250041307A1 (https=)
EP (1) EP4448100A4 (https=)
JP (1) JP2024546600A (https=)
KR (1) KR20240121239A (https=)
AU (1) AU2022410646A1 (https=)
CA (1) CA3240896A1 (https=)
CL (1) CL2024001748A1 (https=)
IL (1) IL313039A (https=)
MX (1) MX2024005884A (https=)
TW (1) TW202339756A (https=)
WO (1) WO2023114456A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2025515045A (ja) * 2022-05-04 2025-05-13 アティラ・ファーマ・インコーポレイテッド 神経炎症病態を治療する方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6184223B1 (en) * 1995-10-27 2001-02-06 Molecumetics Ltd. Reverse-turn mimetics and methods relating thereto
AU2003284120A1 (en) * 2002-10-17 2004-05-04 Myriad Genetics, Inc. Reverse-turn mimetics and composition and methods relating thereto
EP2155226A4 (en) * 2007-06-14 2010-07-28 Univ California COMPOUNDS FOR INHIBITING THE PROTEIN AGGREGATION AND METHOD FOR THE PRODUCTION AND USE THEREOF
KR20130139895A (ko) * 2010-09-02 2013-12-23 다케다 야쿠힌 고교 가부시키가이샤 경도인지 장애의 치료 또는 예방용 융합 트리아졸
CA2817975C (en) * 2010-11-16 2020-03-31 Michael Kahn Cbp/catenin antagonists for enhancing asymmetric division of somatic stem cells
AP2014007606A0 (en) * 2011-10-07 2014-05-31 Takeda Pharmaceutical 1-Arylcarbonyl-4-oxy-piperidine compounds useful for the treatment of neurodegenerative diseases
CN119684295A (zh) * 2020-11-02 2025-03-25 雅斯娜制药公司 用于治疗疾病的双环化合物及其用途

Also Published As

Publication number Publication date
CL2024001748A1 (es) 2024-11-22
WO2023114456A1 (en) 2023-06-22
CA3240896A1 (en) 2023-06-22
KR20240121239A (ko) 2024-08-08
EP4448100A4 (en) 2025-10-22
US20250041307A1 (en) 2025-02-06
IL313039A (en) 2024-07-01
MX2024005884A (es) 2024-05-29
AU2022410646A1 (en) 2024-05-30
JP2024546600A (ja) 2024-12-26
EP4448100A1 (en) 2024-10-23

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