TW202334090A - 用於治療激酶依賴性病症之化合物 - Google Patents
用於治療激酶依賴性病症之化合物 Download PDFInfo
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- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- RCJVRSBWZCNNQT-UHFFFAOYSA-N dichloridooxygen Chemical compound ClOCl RCJVRSBWZCNNQT-UHFFFAOYSA-N 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
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- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
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- 210000003128 head Anatomy 0.000 description 1
- 201000003911 head and neck carcinoma Diseases 0.000 description 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 229940043355 kinase inhibitor Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
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- 235000010355 mannitol Nutrition 0.000 description 1
- 229960001855 mannitol Drugs 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- DDDSGYZATMCUDW-UHFFFAOYSA-N methyl 4-chloro-7-methoxyquinoline-6-carboxylate Chemical compound C1=CN=C2C=C(OC)C(C(=O)OC)=CC2=C1Cl DDDSGYZATMCUDW-UHFFFAOYSA-N 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
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- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
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- 239000003757 phosphotransferase inhibitor Substances 0.000 description 1
- 239000003880 polar aprotic solvent Substances 0.000 description 1
- 238000010935 polish filtration Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
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- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 201000001514 prostate carcinoma Diseases 0.000 description 1
- 108060006633 protein kinase Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000004537 pulping Methods 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
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- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000008109 sodium starch glycolate Substances 0.000 description 1
- 229920003109 sodium starch glycolate Polymers 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163275255P | 2021-11-03 | 2021-11-03 | |
| US63/275,255 | 2021-11-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW202334090A true TW202334090A (zh) | 2023-09-01 |
Family
ID=84462825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW111141900A TW202334090A (zh) | 2021-11-03 | 2022-11-02 | 用於治療激酶依賴性病症之化合物 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP4426678A1 (es) |
| CN (1) | CN118176182A (es) |
| AR (1) | AR127561A1 (es) |
| AU (1) | AU2022383160A1 (es) |
| CA (1) | CA3235602A1 (es) |
| TW (1) | TW202334090A (es) |
| WO (1) | WO2023081253A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019148044A1 (en) * | 2018-01-26 | 2019-08-01 | Exelixis, Inc. | Compounds for the treatment of kinase-dependent disorders |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019148044A1 (en) * | 2018-01-26 | 2019-08-01 | Exelixis, Inc. | Compounds for the treatment of kinase-dependent disorders |
| CN113329790A (zh) * | 2018-12-13 | 2021-08-31 | 埃克塞里艾克西斯公司 | 激酶抑制剂的结晶形式和盐形式 |
| MA56001A (fr) * | 2019-06-03 | 2022-04-06 | Exelixis Inc | Formes de sel cristallin d'un inhibiteur de kinase |
| EP4143169A1 (en) * | 2020-04-30 | 2023-03-08 | Exelixis, Inc. | Processes for the preparation of a kinase inhibitor |
| WO2022098828A1 (en) * | 2020-11-05 | 2022-05-12 | Exelixis, Inc. | Pharmaceutical compositions of a kinase inhibitor |
-
2022
- 2022-11-02 TW TW111141900A patent/TW202334090A/zh unknown
- 2022-11-02 AR ARP220103011A patent/AR127561A1/es unknown
- 2022-11-03 CA CA3235602A patent/CA3235602A1/en active Pending
- 2022-11-03 CN CN202280073218.2A patent/CN118176182A/zh active Pending
- 2022-11-03 EP EP22821747.7A patent/EP4426678A1/en active Pending
- 2022-11-03 AU AU2022383160A patent/AU2022383160A1/en active Pending
- 2022-11-03 WO PCT/US2022/048770 patent/WO2023081253A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| AR127561A1 (es) | 2024-02-07 |
| CA3235602A1 (en) | 2023-05-11 |
| CN118176182A (zh) | 2024-06-11 |
| AU2022383160A1 (en) | 2024-05-02 |
| WO2023081253A1 (en) | 2023-05-11 |
| EP4426678A1 (en) | 2024-09-11 |
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