TW202330529A - 雜環化合物及使用方法 - Google Patents

雜環化合物及使用方法 Download PDF

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Publication number
TW202330529A
TW202330529A TW111130111A TW111130111A TW202330529A TW 202330529 A TW202330529 A TW 202330529A TW 111130111 A TW111130111 A TW 111130111A TW 111130111 A TW111130111 A TW 111130111A TW 202330529 A TW202330529 A TW 202330529A
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TW
Taiwan
Prior art keywords
fluoro
methoxy
pyrrole
pyrido
pyrimidin
Prior art date
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TW111130111A
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English (en)
Chinese (zh)
Inventor
麥可 Ｍ 雅曼儂
云肖 李
普馬黎 韋森狄拉 納維瑞尼
喬斯 Ｍ 麥迪納
寧 陳
林平 皮特斯
瑞恩 洛西諾福
曉芬 李
約翰 史戴爾威根
弗蘭塞斯科 瑪諾尼
李克徐
布萊恩 艾倫 蘭門
萊恩 保羅 烏茲
趙偉
璜 瑞
約瑟芬 艾項
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美商安進公司
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Publication date
Application filed by 美商安進公司 filed Critical 美商安進公司
Publication of TW202330529A publication Critical patent/TW202330529A/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW111130111A 2021-08-10 2022-08-10 雜環化合物及使用方法 TW202330529A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202163231543P 2021-08-10 2021-08-10
US63/231,543 2021-08-10
US202163289579P 2021-12-14 2021-12-14
US63/289,579 2021-12-14

Publications (1)

Publication Number Publication Date
TW202330529A true TW202330529A (zh) 2023-08-01

Family

ID=85201014

Family Applications (1)

Application Number Title Priority Date Filing Date
TW111130111A TW202330529A (zh) 2021-08-10 2022-08-10 雜環化合物及使用方法

Country Status (7)

Country Link
EP (1) EP4384160A4 (https=)
JP (1) JP2024532734A (https=)
AU (1) AU2022325771A1 (https=)
CA (1) CA3228310A1 (https=)
MX (1) MX2024001893A (https=)
TW (1) TW202330529A (https=)
WO (1) WO2023018812A1 (https=)

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JP2025510572A (ja) 2022-03-08 2025-04-15 レボリューション メディシンズ インコーポレイテッド 免疫不応性肺癌を治療するための方法
CA3247639A1 (en) 2022-05-06 2023-11-09 PAQ Therapeutics Inc. CHIMERAS TARGET KRAS-G12D PROTEOLYSIS
WO2023213269A1 (en) * 2022-05-06 2023-11-09 Zai Lab (Shanghai) Co., Ltd. Amide-substituted heterocyclic compounds as kras g12d modulators and uses thereof
CR20240508A (es) 2022-05-19 2024-12-20 Genentech Inc Compuestos aza-tetracíclicos de oxazepina y usos de los mismos
WO2023240263A1 (en) 2022-06-10 2023-12-14 Revolution Medicines, Inc. Macrocyclic ras inhibitors
EP4540244A1 (en) * 2022-06-15 2025-04-23 Mirati Therapeutics, Inc. Prodrugs of pan-kras inhibitors
EP4549439A1 (en) * 2022-07-01 2025-05-07 Suzhou Zelgen Biopharmaceutical Co., Ltd. Substituted pyrimidine-fused ring inhibitor, method for preparing same, and use thereof
WO2024008068A1 (en) * 2022-07-04 2024-01-11 Jacobio Pharmaceuticals Co., Ltd. K-ras mutant protein inhibitors
WO2024012519A1 (zh) * 2022-07-13 2024-01-18 北京华森英诺生物科技有限公司 Pan-kras抑制剂
WO2024041606A1 (zh) * 2022-08-24 2024-02-29 泰励生物科技（上海）有限公司 具有抗kras突变肿瘤活性的化合物
TW202430179A (zh) 2022-11-21 2024-08-01 美商樹線生物科學公司 螺環二氫哌喃并嘧啶ＫＲａｓ抑制劑
US12448399B2 (en) 2023-01-26 2025-10-21 Arvinas Operations, Inc. Cereblon-based KRAS degrading PROTACs and uses related thereto
AU2024241633A1 (en) 2023-03-30 2025-11-06 Revolution Medicines, Inc. Compositions for inducing ras gtp hydrolysis and uses thereof
CR20250420A (es) 2023-04-07 2025-11-20 Revolution Medicines Inc Inhibidores macrocíclicos de ras
AR132338A1 (es) 2023-04-07 2025-06-18 Revolution Medicines Inc Inhibidores de ras
CN121100123A (zh) 2023-04-14 2025-12-09 锐新医药公司 Ras抑制剂的结晶形式
CN121464140A (zh) 2023-04-14 2026-02-03 锐新医药公司 Ras抑制剂的结晶形式、含有其的组合物及其使用方法
TW202508595A (zh) 2023-05-04 2025-03-01 美商銳新醫藥公司 用於ｒａｓ相關疾病或病症之組合療法
US20250049810A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
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US20250109147A1 (en) 2023-09-08 2025-04-03 Gilead Sciences, Inc. Kras g12d modulating compounds
TW202528315A (zh) 2023-09-21 2025-07-16 美商樹線生物科學公司 螺環二氫哌喃并吡啶ＫＲａｓ抑制劑
CN121941690A (zh) 2023-10-03 2026-04-28 Paq医疗公司 Kras蛋白水解靶向嵌合体
TW202529804A (zh) 2023-10-06 2025-08-01 美商安進公司 用於癌症治療的組合療法
US20250114346A1 (en) 2023-10-09 2025-04-10 Incyte Corporation Combination therapy using a kras g12d inhibitor and pd-1 inhibitor or pd-l1 inhibitor
US20250114339A1 (en) 2023-10-09 2025-04-10 Incyte Corporation Combination therapy comprising a kras g12d inhibitor and an egfr inhibitor
AU2024360465A1 (en) 2023-10-12 2026-04-09 Revolution Medicines, Inc. Macrocyclic ras inhibitors
AU2024361909A1 (en) 2023-10-20 2026-03-26 Merck Sharp & Dohme Llc Small molecule inhibitors of kras proteins
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TW202602882A (zh) * 2024-03-14 2026-01-16 美商安進公司 作為ｋｒａｓ調節劑的大環化合物及其用途
WO2025194054A1 (en) * 2024-03-14 2025-09-18 Amgen Inc. Spirocyclic compounds as modulators of kras and uses thereof
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CN103588792B (zh) * 2013-03-04 2016-03-23 中国科学院上海药物研究所 吡啶并嘧啶或嘧啶并嘧啶类化合物、其制备方法、药物组合物及其用途
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MX2022002465A (es) * 2019-08-29 2022-05-19 Mirati Therapeutics Inc Inhibidores de kras g12d.
JP2023553492A (ja) * 2020-12-15 2023-12-21 ミラティ セラピューティクス， インコーポレイテッド アザキナゾリン汎ＫＲａｓ阻害剤
CN117222650A (zh) * 2021-04-30 2023-12-12 劲方医药科技(上海)有限公司 吡啶或嘧啶并环类化合物，其制法与医药上的用途
BR112023024906A2 (pt) * 2021-05-28 2024-02-15 Redx Pharma Plc Compostos

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Publication number Publication date
JP2024532734A (ja) 2024-09-10
EP4384160A1 (en) 2024-06-19
AU2022325771A1 (en) 2024-02-15
MX2024001893A (es) 2024-02-29
CA3228310A1 (en) 2023-02-16
WO2023018812A1 (en) 2023-02-16
EP4384160A4 (en) 2025-10-29

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