TW202321247A - 用於治療杭丁頓氏舞蹈症的雜芳基化合物 - Google Patents

用於治療杭丁頓氏舞蹈症的雜芳基化合物 Download PDF

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Publication number
TW202321247A
TW202321247A TW111128808A TW111128808A TW202321247A TW 202321247 A TW202321247 A TW 202321247A TW 111128808 A TW111128808 A TW 111128808A TW 111128808 A TW111128808 A TW 111128808A TW 202321247 A TW202321247 A TW 202321247A
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TW
Taiwan
Prior art keywords
pyrrolo
phenol
triazol
compound
fluoro
Prior art date
Application number
TW111128808A
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English (en)
Chinese (zh)
Inventor
蘇雷什 巴布
勞富爾 阿拉姆
阿努拉達 巴塔查裡亞
光明 陳
伊斯特伍德 馬修 S
賽義德莫特薩 侯賽尼
瑤 江
卡普 蓋瑞 米切爾
揚春 穆恩
賈娜 納拉辛漢
洪玉 任
娜迪亞 瑟多倫科
沃爾 馬修 G
張南京
Original Assignee
美商Ptc醫療公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 美商Ptc醫療公司 filed Critical 美商Ptc醫療公司
Publication of TW202321247A publication Critical patent/TW202321247A/zh

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/5025Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
TW111128808A 2021-07-30 2022-08-01 用於治療杭丁頓氏舞蹈症的雜芳基化合物 TW202321247A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163203761P 2021-07-30 2021-07-30
US63/203,761 2021-07-30

Publications (1)

Publication Number Publication Date
TW202321247A true TW202321247A (zh) 2023-06-01

Family

ID=83149486

Family Applications (1)

Application Number Title Priority Date Filing Date
TW111128808A TW202321247A (zh) 2021-07-30 2022-08-01 用於治療杭丁頓氏舞蹈症的雜芳基化合物

Country Status (16)

Country Link
US (1) US20240336613A1 (enExample)
EP (1) EP4377317A1 (enExample)
JP (1) JP2024528066A (enExample)
KR (1) KR20240054264A (enExample)
CN (1) CN118159539A (enExample)
AR (1) AR126612A1 (enExample)
AU (1) AU2022320725A1 (enExample)
CA (1) CA3227287A1 (enExample)
CL (1) CL2024000250A1 (enExample)
CO (1) CO2024000890A2 (enExample)
CR (1) CR20240043A (enExample)
IL (1) IL310440A (enExample)
MX (1) MX2024001417A (enExample)
PE (1) PE20240929A1 (enExample)
TW (1) TW202321247A (enExample)
WO (1) WO2023009816A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2018282154B2 (en) 2017-06-05 2022-04-07 Ptc Therapeutics, Inc. Compounds for treating huntington's disease
AU2019243048A1 (en) 2018-03-27 2020-10-15 Ptc Therapeutics, Inc. Compounds for treating Huntington's disease
IL279688B2 (en) 2018-06-27 2025-01-01 Ptc Therapeutics Inc Heterocyclic and heteroaryl compounds for the treatment of Huntington's disease
BR112020026534A2 (pt) 2018-06-27 2021-03-23 Ptc Therapeutics, Inc. Compostos de heteroarila para o tratamento da doença de huntington
CN114245794B (zh) 2019-05-13 2024-09-13 Ptc医疗公司 用于治疗亨廷顿氏病的化合物
CN119451674A (zh) * 2022-06-15 2025-02-14 Ptc医疗公司 用于治疗亨廷顿病的杂环和杂芳基化合物
EP4719599A1 (en) 2023-06-02 2026-04-08 Merck Sharp & Dohme LLC 5,6 unsaturated bicyclic heterocyles useful as inhibitors of nod-like receptor protein 3

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL279688B2 (en) * 2018-06-27 2025-01-01 Ptc Therapeutics Inc Heterocyclic and heteroaryl compounds for the treatment of Huntington's disease
WO2020005882A1 (en) * 2018-06-27 2020-01-02 Ptc Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
JP2022525417A (ja) * 2019-03-15 2022-05-13 スカイホーク・セラピューティクス・インコーポレーテッド 異常スプライシングを修正するための組成物および方法

Also Published As

Publication number Publication date
CA3227287A1 (en) 2023-02-02
KR20240054264A (ko) 2024-04-25
US20240336613A1 (en) 2024-10-10
CR20240043A (es) 2024-05-22
WO2023009816A1 (en) 2023-02-02
AR126612A1 (es) 2023-10-25
CL2024000250A1 (es) 2024-07-12
MX2024001417A (es) 2024-05-14
AU2022320725A1 (en) 2024-02-22
IL310440A (en) 2024-03-01
JP2024528066A (ja) 2024-07-26
CO2024000890A2 (es) 2024-04-29
PE20240929A1 (es) 2024-04-30
EP4377317A1 (en) 2024-06-05
CN118159539A (zh) 2024-06-07

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