TW202313476A - Method for recovering zinc-68 isotope from the preparation method of copper-64 - Google Patents

Abstract

The present invention is a method for recovering zinc-68 isotope from the preparation method of copper-64. In the method of preparing the copper-64 isotope from the zinc-68 solid target, the zinc-68 isotope produced by the zinc-68 solid target is further recovered. And the recovered zinc-68 isotope is reused in the preparation method of copper-64 to reduce material cost.

Description

Method for recovering zinc-68 isotope from copper-64 process

The present invention relates to a method for recovering zinc-68 isotope, especially a method for recovering zinc-68 isotope from copper-64 process.

In recent years, Positron Emission Tomography (PET) has risen rapidly and has become an important diagnostic imaging mode in medicine. It is mainly used to determine the occurrence and severity of cancer, the condition of the nervous system and the cardiovascular system. aspects of the disease.

At present, PET has been recognized as particularly effective in certain diseases, including judging whether cancer exists, whether it has spread, whether it responds to treatment, whether the cancer recurs, and whether the patient no longer has cancer cells after treatment. Cancers in which PET is particularly effective include lung, head and neck, colorectal, esophagus, lymphoma, melanoma, breast, thyroid, cervix, pancreas, and brain tumors.

In short, to use PET imaging, it is necessary to inject radiopharmaceuticals into the patient. The radiopharmaceuticals release signals in the patient's body, which are received by the PET scanner outside the body and then form images. The images captured by PET can show A chemical change in an organ or tissue, such as a tumor.

Furthermore, radioactive isotopes can be used in the diagnosis or treatment of diseases after they are developed into nucleated pharmaceutical dosage forms according to the types of radiation they release. The cyclotron is an important isotope generator for clinical nuclear medicine. It can produce medium and long half-life isotopes such as thallium-201, indium-111, iodine-123, fluorine-18 and gallium-67, as well as carbon-11, oxygen-15 and Nuclear species with a short half-life such as nitrogen-13 are used in the diagnosis of cardiovascular diseases, thyroid function, tumors, inflammation and metabolic diseases, etc.

With the development of nuclear medicine and clinical needs, in addition to the development of isotopes for diagnosis, cyclotrons have gradually attracted attention to the production and application of isotopes for treatment. Among them, the radioactive isotope copper-64, which has both diagnostic and therapeutic functions, has received special attention. .

Copper-64 has a moderate half-life (12.7 hours) and can release energy of 511keV, which is suitable for PET imaging. It can also release beta rays of 1346keV, which has therapeutic potential. Copper-64 combined with appropriate ligands (such as small molecular compounds, peptides or monoclonal antibodies) can be used in the diagnosis or treatment of diseases.

However, the half-life of copper-64 is only 12.7 hours, and it is not easy to preserve. In view of this, the development of copper-64 isotope is usually carried out in a 30MeV medium-sized cyclotron, which is to electroplate the high-abundance stable isotope nickel-64 on the solid target. Irradiate with a proton beam of 15-18 MeV, and then undergo separation and purification steps to obtain high-purity radioactive isotope copper-64.

However, nickel-64, a highly abundant stable isotope, is quite expensive. In order to save cost, the technology of preparing gallium-67 isotope with zinc-68 solid target through cyclotron irradiation has been established. And referring to the nuclear reaction diagram of zinc-68, it can be seen that in addition to gallium-66, gallium-67 and gallium-68, another important product is copper-64.

However, the technology of simultaneously producing two valuable radioisotopes gallium-67 and copper-64 through cyclotron irradiation on a zinc-68 solid target has been established. However, the price of zinc-68 solid target is expensive, and it cannot meet the actual needs of users if only relying on imports.

For this reason, it is a problem to be solved by those skilled in the art to save the cost of raw materials, reduce the cost of nuclear medicine, and reduce the pollution to the environment under the condition of sufficient supply to patients without restriction.

The main purpose of the present invention is to provide a method for reclaiming zinc-68 isotope from the copper-64 process, in which the zinc-68 solid target is irradiated by a cyclotron to produce the radioactive isotope copper-64, further reclaiming zinc-68 again It is used in the copper-64 process to reduce the cost of raw materials.

In order to achieve the above purpose and effect, the present invention discloses a method for recovering zinc-68 isotope from the copper-64 process. Zinc hydroxide; take the zinc hydroxide to adjust the pH value, and adjust the zinc hydroxide to a pH value between 10 and 11; take the zinc hydroxide to perform an electroplating reaction, and react to form a finished solution containing zinc ions; and The product solution containing zinc ions is subjected to a heat concentration treatment to form a zinc-68 isotope.

The present invention provides an embodiment, which is a method for recovering zinc-68 isotope from the copper-64 process, wherein in the step of taking a copper-64 washing raffinate and a hydroxide for a precipitation reaction, the copper-64 The washing raffinate contains a zinc ion, a gallium ion and a copper ion.

The present invention provides an embodiment, which is a method for recovering zinc-68 isotope from the copper-64 process, wherein in the step of taking a copper-64 washing raffinate and a hydroxide for a precipitation reaction, the copper-64 The washing residue is recovered from a copper-64 process in which a proton beam irradiates a zinc-68 solid target.

The present invention provides an embodiment, which is a method for recovering zinc-68 isotope from the copper-64 process, wherein in the step of taking a copper-64 washing raffinate and a hydroxide for a precipitation reaction, the hydroxide Department of sodium hydroxide.

The present invention provides an embodiment, the content of which is the method for recovering zinc-68 isotope from the copper-64 process, wherein in the step of taking the zinc hydroxide to adjust the pH value, the pH value adjustment is through a sodium hydroxide and A hydrochloric acid to adjust.

The present invention provides an embodiment, the content of which is the method for recovering zinc-68 isotope from the copper-64 process, wherein after the step of adjusting the pH value of the zinc hydroxide, further comprising the step of: taking the zinc hydroxide for a Vacuum filtration process.

The present invention provides an embodiment, which is a method for recovering zinc-68 isotope from the copper-64 process, wherein in the step of taking the zinc hydroxide for an electroplating reaction, a nitrogen gas is further added to the electroplating reaction.

In order to enable your review committee members to have a further understanding and understanding of the characteristics of the present invention and the achieved effects, the following examples and accompanying descriptions are hereby provided:

In view of the high cost of nuclear raw materials, it cannot be fully supplied to patients. Accordingly, the present invention proposes a method for recovering zinc-68 isotope from the copper-64 process to solve the problems caused by the prior art.

A method for recovering zinc-68 isotope from the copper-64 process of the present invention will be further described below, including its included characteristics, matching structure and method:

First of all, please refer to FIG. 1, which is a flowchart of the steps of an embodiment of the present invention. As shown in the figure, a method of recovering zinc-68 isotope from the copper-64 process of the present invention, the steps include:

S1: Take the copper-64 water washing residue and carry out precipitation reaction with hydroxide to form zinc hydroxide;

S2: Take zinc hydroxide to adjust the pH value, and adjust the zinc hydroxide to a pH value between 10 and 11;

S3: taking zinc hydroxide for electroplating reaction to form a finished solution containing zinc ions; and

S4: Take the finished liquid containing zinc ions and conduct heat concentration treatment to form zinc-68 isotope.

As shown in step S1, take a copper-64 washing residue and carry out a precipitation reaction with a hydroxide to form zinc hydroxide, wherein the hydroxide is sodium hydroxide. Moreover, the copper-64 washing residue of the present invention is recovered from a copper-64 process, and the copper-64 process is a zinc-68 solid target irradiated by a proton beam.

The detailed process of the copper-64 manufacturing process of the present invention is as follows: the present invention adopts the copper-based silver target of the cyclotron, and first electroplates high-abundance zinc-68 (abundance greater than 98%) on the copper-based silver target on the target surface (forming the zinc-68 solid target), and sent to the cyclotron for irradiation, followed by the proton impact reaction at 29 ± 2 MeV, and then dissolved in the HCL solution with an equivalent concentration of 9N, and chemically purified Separation procedure yields gallium-67 isotope. At the same time, gallium-67 acid washing waste liquid was collected.

Afterwards, pass the gallium-67 acid washing waste liquid through the first column filled with cation exchange resin (AG50W-X2, 100-200mesh, hydrogen form), and continue to add 10 mL of 9N HCl solution to wash the first column , and collect the effluent from the first column. Then, pass the effluent from the first column through the second column filled with anion exchange resin (AG 1-X8, 100-200mesh, chloride form, Bio-Rad), and continue to add 40 mL of 9N HCl solution to wash the second column, and collect the effluent of the second column.

Finally, an appropriate amount of about 1N to 2N HCl solution was added to the second column, and the effluent was collected. Its effluent contains high-purity copper-64 isotope. And after the effluent flows out, further add an appropriate amount of water to the second column, and collect the liquid that flows out, which is the copper-64 water washing raffinate of the present invention. Therefore, the copper-64 washing raffinate of the present invention contains a zinc ion, a gallium ion and a copper ion.

Then, as shown in step S2, the zinc hydroxide is taken to adjust the pH value, and the zinc hydroxide is adjusted to a pH value between 10 and 11. The pH value adjustment is adjusted through sodium hydroxide and hydrochloric acid. The detailed process of the pH value adjustment is as follows: add 2N NaOH solution one by one until the pH value of the zinc hydroxide reaches between 10 and 11, if the pH value is less than 10, add 2N NaOH, if it is greater than 11, add HCl (0.1 to 0.5N) . The zinc hydroxide was allowed to precipitate in large quantities and was pumped out.

After step S2 is continued, the zinc hydroxide is continuously stirred for 0.5-2 hours (preferably 1 hour), and the rotating speed of the electric heating plate magnet is set at 300-500 RPM. The process further includes step S21: taking the zinc hydroxide and performing a vacuum filtration process. After the vacuum filtration process, use 300ml of water to rinse the zinc hydroxide (in the shape of a filter cake) three times.

Furthermore, as shown in step S3, the zinc hydroxide is taken in the filter cup to perform an electroplating reaction, and a nitrogen gas is further added to the electroplating reaction to promote dissolution. In the electroplating reaction, 20 ml of the electroplating precursor solution should be added to every 1 gram of the zinc hydroxide. After the electroplating reaction, a finished solution containing zinc ions is formed, which is temporarily stored in the finished bottle.

After the electroplating reaction, rinse the filter cup with 300ml of water three times, and temporarily store the finished solution containing zinc ions remaining in the filter cup in the finished product bottle.

Finally, as shown in step S4, the finished product solution containing zinc ions is placed in an 800ml beaker, and a heating and concentration process is carried out on an electric heating plate, and the temperature of the heating and concentration process is between 200 and 400°C ( preferably 275°C). Also, the rotation speed of the magnet is between 80 to 120 RPM (preferably 100 RPM), and finally a zinc-68 isotope is formed. In this heat concentration treatment, every 1 gram of zinc needs to be concentrated to 20 ml of the finished solution containing zinc ions.

The following is a detailed process of a preferred embodiment of the present invention: take the copper-64 water washing residue and carry out precipitation reaction with hydroxide (sodium hydroxide), and react to form zinc hydroxide. Then adjust the pH value of the zinc hydroxide, and adjust it to a pH between 10 and 11. Furthermore, further get zinc hydroxide and continue to stir for 1 hour, and the electric heating plate magnet speed setting is 300～500RPM. Continue to further take zinc hydroxide for vacuum filtration process. After the vacuum filtration process, use 300ml of water to rinse the zinc hydroxide (it is already in the form of a filter cake) three times.

Also, take zinc hydroxide in the filter cup to carry out electroplating reaction, and further add nitrogen gas to promote dissolution in the electroplating reaction. After the electroplating reaction, a finished product solution containing zinc ions is formed, which is temporarily stored in the finished product bottle.

Finally, heat and concentrate the product solution containing zinc ions (at 275° C. and 100 RPM), and obtain zinc-68 isotope from the product solution containing zinc ions after the heat concentration treatment.

Therefore, the present invention is novel, progressive and can be used in industry. It should meet the patent application requirements of my country's patent law. I file an invention patent application in accordance with the law. I pray that the bureau will grant the patent as soon as possible. I sincerely pray.

However, the above-mentioned ones are only preferred embodiments of the present invention, and are not used to limit the scope of the present invention. For example, all equal changes and modifications are made according to the shape, structure, characteristics and spirit described in the scope of the patent application of the present invention. , should be included in the patent application scope of the present invention.

S1~S4: Step process

Fig. 1: It is a flowchart of the steps of one embodiment of the present invention.

S1~S4: Step process

Claims (7)

A method for recovering zinc-68 isotope from the copper-64 process, the steps comprising: Take a copper-64 water washing raffinate and carry out a precipitation reaction with a hydroxide, and the reaction generates zinc hydroxide; Taking the zinc hydroxide to adjust the pH value, adjusting the zinc hydroxide to a pH value between 10 and 11; Taking the zinc hydroxide to carry out an electroplating reaction to form a finished solution containing zinc ions; and The product solution containing zinc ions is subjected to a heat concentration treatment to form a zinc-68 isotope. The method for recovering zinc-68 isotope from the copper-64 process as described in claim 1, wherein in the step of taking a copper-64 washing raffinate and a hydroxide to carry out a precipitation reaction, the copper-64 washing raffinate The system contains a zinc ion, a gallium ion and a copper ion. The method for recovering zinc-68 isotope from the copper-64 process as described in claim 1, wherein in the step of taking a copper-64 washing raffinate and a hydroxide to carry out a precipitation reaction, the copper-64 washing raffinate It is recovered from a copper-64 process in which a proton beam irradiates a zinc-68 solid target. The method for recovering zinc-68 isotope from the copper-64 process as described in claim 1, wherein in the step of taking a copper-64 water washing raffinate and a hydroxide to carry out a precipitation reaction, the hydroxide is hydroxide sodium. The method for recovering zinc-68 isotope from the copper-64 process as described in claim 1, wherein in the step of adjusting the pH value of the zinc hydroxide, the pH value adjustment is carried out through a sodium hydroxide and a hydrochloric acid Adjustment. The method for recovering zinc-68 isotope from the copper-64 process as described in claim 1, wherein after taking the zinc hydroxide to carry out a pH value adjustment step, further comprising the step of: taking the zinc hydroxide to carry out a vacuum filtration process . The method for recovering zinc-68 isotope from the copper-64 process as described in claim 1, wherein in the step of taking the zinc hydroxide and performing an electroplating reaction, a nitrogen gas is further added to the electroplating reaction.

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