CN117959932A - System and method for purifying radionuclide 89Zr hydrochloric acid oxalic acid double system - Google Patents
System and method for purifying radionuclide 89Zr hydrochloric acid oxalic acid double system Download PDFInfo
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- CN117959932A CN117959932A CN202410047834.1A CN202410047834A CN117959932A CN 117959932 A CN117959932 A CN 117959932A CN 202410047834 A CN202410047834 A CN 202410047834A CN 117959932 A CN117959932 A CN 117959932A
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- KQPMFNHZHBLVRR-UHFFFAOYSA-N oxalic acid;hydrochloride Chemical compound Cl.OC(=O)C(O)=O KQPMFNHZHBLVRR-UHFFFAOYSA-N 0.000 title claims abstract description 16
- 238000000034 method Methods 0.000 title claims abstract description 14
- 238000000746 purification Methods 0.000 claims abstract description 80
- 239000002994 raw material Substances 0.000 claims abstract description 41
- 239000011347 resin Substances 0.000 claims abstract description 17
- 229920005989 resin Polymers 0.000 claims abstract description 17
- DAWBXZHBYOYVLB-UHFFFAOYSA-J oxalate;zirconium(4+) Chemical compound [Zr+4].[O-]C(=O)C([O-])=O.[O-]C(=O)C([O-])=O DAWBXZHBYOYVLB-UHFFFAOYSA-J 0.000 claims abstract description 14
- DUNKXUFBGCUVQW-UHFFFAOYSA-J zirconium tetrachloride Chemical compound Cl[Zr](Cl)(Cl)Cl DUNKXUFBGCUVQW-UHFFFAOYSA-J 0.000 claims abstract description 11
- 239000007788 liquid Substances 0.000 claims description 54
- 239000002699 waste material Substances 0.000 claims description 44
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 31
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 29
- 230000002572 peristaltic effect Effects 0.000 claims description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 239000012535 impurity Substances 0.000 claims description 11
- 235000006408 oxalic acid Nutrition 0.000 claims description 10
- 230000009977 dual effect Effects 0.000 claims description 6
- 230000001105 regulatory effect Effects 0.000 claims description 5
- 239000013077 target material Substances 0.000 claims description 5
- VWQVUPCCIRVNHF-IGMARMGPSA-N yttrium-89 atom Chemical compound [89Y] VWQVUPCCIRVNHF-IGMARMGPSA-N 0.000 claims description 5
- 238000010828 elution Methods 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 2
- -1 zirconium 89 ions Chemical class 0.000 claims 1
- 239000000047 product Substances 0.000 abstract description 24
- 239000012264 purified product Substances 0.000 abstract description 3
- QCWXUUIWCKQGHC-YPZZEJLDSA-N zirconium-89 Chemical compound [89Zr] QCWXUUIWCKQGHC-YPZZEJLDSA-N 0.000 description 6
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- 229910052726 zirconium Inorganic materials 0.000 description 4
- 238000002372 labelling Methods 0.000 description 3
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 230000002285 radioactive effect Effects 0.000 description 2
- OBOSXEWFRARQPU-UHFFFAOYSA-N 2-n,2-n-dimethylpyridine-2,5-diamine Chemical compound CN(C)C1=CC=C(N)C=N1 OBOSXEWFRARQPU-UHFFFAOYSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 230000005266 beta plus decay Effects 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000005264 electron capture Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- VSZWPYCFIRKVQL-UHFFFAOYSA-N selanylidenegallium;selenium Chemical compound [Se].[Se]=[Ga].[Se]=[Ga] VSZWPYCFIRKVQL-UHFFFAOYSA-N 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 229910052727 yttrium Inorganic materials 0.000 description 1
- VWQVUPCCIRVNHF-UHFFFAOYSA-N yttrium atom Chemical compound [Y] VWQVUPCCIRVNHF-UHFFFAOYSA-N 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D59/00—Separation of different isotopes of the same chemical element
- B01D59/22—Separation by extracting
- B01D59/26—Separation by extracting by sorption, i.e. absorption, adsorption, persorption
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/47—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E30/00—Energy generation of nuclear origin
- Y02E30/30—Nuclear fission reactors
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
Abstract
The hydrochloric acid oxalic acid double-system purification system of the radionuclide 89Zr comprises a first power pump, a first three-way pipe, a second three-way pipe and a third three-way pipe which are connected in series with a first interface of the first power pump, wherein the first three-way pipe, the second three-way pipe and the third three-way pipe are also respectively connected with a first raw material bottle, a second raw material bottle and a third raw material bottle, and the third three-way pipe is also connected with a fourth raw material bottle; the second interface of the first power pump is connected with a first three-way valve, and the other two interfaces of the first three-way valve are respectively connected with a second three-way valve and a first purification column. The invention also discloses a method for purifying the radionuclide 89Zr hydrochloric acid oxalic acid double system. According to the invention, the 89ZR is separated by using the resin, so that two purified products of zirconium oxalate and zirconium chloride can be provided for a user, and the problem of single product is solved.
Description
Technical Field
The invention belongs to the technical field of radioactive isotopes, relates to a radioactive isotope purification technology, and in particular relates to a hydrochloric acid oxalic acid double-system purification system and method of radionuclide 89 Zr.
Background
Zirconium 89 (89 Zr) is a novel positron species with a half-life of 78.4h and decay modes of 22% beta + decay (0.9 MeV) and 77.26% electron capture. The nuclear physical properties of 89ZR can be matched with those of some antibodies with similar biological half-aging bodies and PET immune imaging is carried out on the antibody marks, and meanwhile, the method is also suitable for preparing radioisotope marked clone antibody medicines, and is expected to be used for the target diagnosis and treatment of clinical tumors. In general, both zirconium oxalate and zirconium chloride can be used to prepare radiolabels of radiolabeled 89 Zr. They may be used in different situations for labeling drugs or other compounds.
The current purification mode of 89Zr in the prior art mainly comprises solvent extraction, ion exchange chromatography, solid phase carboxylate resin and the like, and the obtained target products are single zirconium oxalate or zirconium chloride, and can not simultaneously obtain zirconium oxalate and zirconium chloride in one system. It is therefore desirable to provide a hydrochloric acid, oxalic acid dual system purification system for radionuclide ZR-89.
Disclosure of Invention
In order to overcome the defects in the prior art, the invention discloses a hydrochloric acid oxalic acid double-system purification system and method of radionuclide 89 Zr.
The invention discloses a radionuclide 89Zr hydrochloric acid oxalic acid double-system purification system, which comprises a first power pump, a first three-way pipe, a second three-way pipe and a third three-way pipe, wherein the first three-way pipe, the second three-way pipe and the third three-way pipe are connected in series with a first interface of the first power pump, the first raw material bottle, the second raw material bottle and the third raw material bottle are respectively connected with the first three-way pipe, the second three-way pipe and the third three-way pipe, and the third three-way pipe is also connected with a fourth raw material bottle;
The second interface of the first power pump is connected with a first three-way valve, the other two interfaces of the first three-way valve are respectively connected with a second three-way valve and a first purification column, the other interface of the first purification column is connected with a fourth three-way pipe, a fifth three-way pipe and a sixth three-way pipe in series, wherein the fourth three-way pipe, the fifth three-way pipe and the sixth three-way pipe are also respectively connected with a first waste liquid bottle, a second waste liquid bottle and a third waste liquid bottle, and the sixth three-way pipe is also connected with a first product bottle;
the first product bottle is connected with a second three-way valve through a second power pump, the second three-way valve is also connected with a second purification column, the other interface of the second purification column is connected with a seventh three-way pipe, and the seventh three-way pipe is also connected with a third waste liquid bottle and a second product bottle;
control valves are connected between the three-way pipe and the raw material bottle, between the three-way pipe and the waste liquid bottle and between the three-way pipe and the product bottle, and the first purifying column is ZR resin and the second purifying column is QMA resin.
Preferably, the power pump is a peristaltic pump.
Preferably, the control valve is a pinch valve.
Preferably, the system further comprises a controller in control connection with each three-way valve, the control valve and the power pump.
The invention also discloses a method for purifying the radionuclide 89Zr hydrochloric acid oxalic acid double system, which is based on the purification system, and comprises the following steps:
Step 1, firstly, a first three-way valve F1 is regulated to be communicated with a first power pump P1 and a first purification column R1, then a first control valve and a fifth control valve are opened, the first power pump and other pinch valves are closed;
under the pushing action of the first power pump, the target water dissolved in the first raw material bottle flows through the first purification column through the pipeline, the target object is adsorbed by the first purification column, and the waste liquid enters the first waste liquid bottle;
the target water is a liquid containing 89Zr ions;
Step 2, closing the first control valve and the fifth control valve, opening the second control valve and the sixth control valve, enabling hydrochloric acid liquid in the second raw material bottle to flow through the first purification column by virtue of the first power pump under the pushing action, eluting target material impurities remained on the purification column, and enabling waste liquid to enter the second waste liquid bottle;
And 3, closing the second control valve and the sixth control valve. Opening a third control valve and a seventh control valve, enabling liquid water in the third raw material bottle to flow through the first purification column by virtue of the pushing action of the first power pump, eluting impurities remained on the purification column, and enabling waste liquid to enter a third waste liquid bottle;
Step 4, closing the third control valve, the seventh control valve, opening the fourth control valve and the eighth control valve, enabling oxalic acid solution in the fourth raw material bottle to flow through the first purification column through the pipeline under the pushing action of the first power pump, eluting 89ZR on the first purification column, and entering the first product bottle;
Obtaining a product zirconium oxalate 89 solution obtained after elution and oxalic acid reaction in a first product bottle;
step 5, closing the fourth control valve, the eighth control valve and the first power pump;
step 6, the second three-way valve is regulated to be communicated with the second power pump P2 and the second purifying column R2 only, the second power pump and the ninth control valve are opened, and under the pushing action of the second power pump, the zirconium oxalate 89 solution in the first product bottle flows through the second purifying column and enters the third waste liquid bottle, and the second purifying column is QMA resin;
step 7, closing the second power pump, and adjusting the first three-way valve and the second three-way valve to the state that the second three-way valve is only communicated with the first three-way valve and the seventh three-way pipe, wherein the first three-way valve is also connected with the first power pump;
Opening a third control valve and a first power pump, enabling water in a third raw material bottle to flow through a second purification column under the pushing action of the first power pump, eluting residual impurities on the second purification column, and enabling waste liquid to enter a third waste liquid bottle;
And 8, closing a third control valve and a ninth control valve, opening a second control valve and a tenth control valve, enabling hydrochloric acid in the second raw material bottle to flow through the second purification column under the pushing action of the first power pump, eluting 89ZR on the purification column, reacting to obtain zirconium chloride, and entering a second product bottle.
Preferably, the preparation method of the target water in the first raw material bottle comprises the following steps: the yttrium 89 is continuously bombarded by protons to prepare a target slice, after the bombardment is performed for more than 3 hours, 6 mol/L HCl is used for dissolving to obtain target water, and the mass volume ratio of the target slice to the hydrochloric acid solution is 0.8-2 ml corresponding to each 100 mg of target slice.
The purification system can realize automation, reduce artificial radiation dosage and automatically and quantitatively adjust the purification form to zirconium chloride or zirconium oxalate by separating 89ZR by using ZR resin and QMA resin. The invention not only can meet the separation and purification process of 89ZR produced by a matched cyclotron, but also can provide two purified products of zirconium oxalate and zirconium chloride for users, and solves the problem of single product. The full-automatic operation is adopted in the whole process, so that irradiation damage can be reduced, purification time is shortened, and purification efficiency of 89ZR is improved.
Drawings
FIG. 1 is a schematic diagram of one embodiment of a dual system purification system for oxalic acid hydrochloride of radionuclide 89Zr according to the present invention;
FIG. 2 is a schematic flow chart of one embodiment of the dual system purification method of oxalic acid hydrochloride for radionuclide 89Zr according to the present invention.
Description of the embodiments
The following describes the present invention in further detail.
For the purpose of making the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be clearly and completely explained below in connection with the detailed description of the present invention and the corresponding drawings, and it is obvious that the described embodiments are only some, but not all, embodiments of the present invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The invention discloses a radionuclide 89Zr hydrochloric acid oxalic acid double-system purification system, which comprises a first power pump, a first three-way pipe, a second three-way pipe and a third three-way pipe, wherein the first three-way pipe, the second three-way pipe and the third three-way pipe are connected in series with a first interface of the first power pump, the first raw material bottle, the second raw material bottle and the third raw material bottle are respectively connected with the first three-way pipe, the second three-way pipe and the third three-way pipe, and the third three-way pipe is also connected with a fourth raw material bottle;
The second interface of the first power pump is connected with a first three-way valve, the other two interfaces of the first three-way valve are respectively connected with a second three-way valve and a first purification column, the other interface of the first purification column is connected with a fourth three-way pipe, a fifth three-way pipe and a sixth three-way pipe in series, wherein the fourth three-way pipe, the fifth three-way pipe and the sixth three-way pipe are also respectively connected with a first waste liquid bottle, a second waste liquid bottle and a third waste liquid bottle, and the sixth three-way pipe is also connected with a first product bottle;
the first product bottle is connected with a second three-way valve through a second power pump, the second three-way valve is also connected with a second purification column, the other interface of the second purification column is connected with a seventh three-way pipe, and the seventh three-way pipe is also connected with a third waste liquid bottle and a second product bottle;
control valves are connected between the three-way pipe and the raw material bottle, between the three-way pipe and the waste liquid bottle and between the three-way pipe and the product bottle, and the first purifying column is ZR resin and the second purifying column is QMA resin.
Wherein, peristaltic pump can be used as the power pump, and pinch valve can be used as the control valve, and one embodiment is shown in fig. 1.
The method for purifying the radionuclide 89Zr hydrochloric acid oxalic acid double system, as shown in figure 2, comprises the following steps:
Step 1, firstly, a first three-way valve F1 is regulated to be communicated with a first peristaltic pump P1 and a first purification column R1, then a first pinch valve C1 and a fifth pinch valve C5 are opened, the first peristaltic pump P1 is closed, and all other pinch valves are closed;
Under the pushing action of the first peristaltic pump P1, the target water dissolved in the first raw material bottle X1 flows through the first purification column R1 by the pipeline, the target 89Zr is adsorbed by the first purification column, and the waste liquid enters the first waste liquid bottle X5.
The target water is a solution containing 89Zr ions, and can be prepared by bombarding a target piece made of yttrium 89 (89Y) by utilizing protons, bombarding for 3-6 hours, dissolving the target piece by adopting 6mol/L HCl to obtain the target water, wherein the volume ratio of the target piece to the hydrochloric acid solution is 500 mg, corresponding to 4mL of hydrochloric acid, and the first purification column is Zirconium (ZR) resin.
And 2, closing the first pinch valve C1 and the fifth pinch valve C5, opening the second pinch valve C2 and the sixth pinch valve C6, enabling hydrochloric acid liquid in the second raw material bottle X2 to flow through the first purification column R1 through a pipeline under the pushing action of the first peristaltic pump, eluting impurities such as target materials and the like remained on the purification column, and enabling waste liquid to enter the second waste liquid bottle X6.
In the step, the concentration of hydrochloric acid in the second raw material bottle X2 is 2 mol/liter, and the waste liquid mainly comprises hydrochloric acid and target material yttrium 89 which react to generate yttrium chloride;
And 3, closing the second pinch valve C2 and the sixth pinch valve C6. And opening the third pinch valve C3 and the seventh pinch valve C7, enabling liquid water in the third raw material bottle X3 to flow through the first purification column R1 by the pipe under the pushing action of the first peristaltic pump, eluting residual impurities on the purification column, and enabling waste liquid to enter the third waste liquid bottle X7.
Deionized water is adopted in the third raw material bottle.
And 4, closing the third pinch valve C3, the seventh pinch valve C7, opening the fourth pinch valve C4 and the eighth pinch valve C8, enabling oxalic acid solution in the fourth raw material bottle X4 to flow through the first purifying column R1 through a pipeline under the pushing action of the first peristaltic pump, eluting 89ZR on the first purifying column, and entering the first product bottle X8.
Wherein the concentration of the oxalic acid solution is 0.1-1 mol per liter.
The first product bottle X8 is provided with a zirconium oxalate 89 which is obtained after elution and oxalic acid reaction.
Step 5. Closing the fourth pinch valve C4, the eighth pinch valve C8 and the first peristaltic pump P1.
And 6, adjusting the second three-way valve F2 to be communicated with the second peristaltic pump P2 and the second purification column R2, opening the second peristaltic pump P2 and the ninth pinch valve C9, and enabling the liquid in the first product bottle X8 to flow through the second purification column R2 and enter the third waste liquid bottle X9 under the pushing action of the second peristaltic pump. The second purification column was a QMA resin, and after the zirconium oxalate 89 passed through the QMA (quaternium METHYL AMINE Ji Jiaan) resin, 89Zr was adsorbed on the QMA resin, and the oxalate was introduced into the waste liquid bottle X9.
Step 7, closing the second peristaltic pump P2, and adjusting the first three-way valve F1 and the second three-way valve F2 to a state that the second three-way valve F2 is only communicated with the first three-way valve F1 and the seventh three-way pipe T7, wherein the first three-way valve F1 is also connected with the first peristaltic pump;
And opening the third pinch valve C3 and the first peristaltic pump P1, enabling water in the third raw material bottle X3 to flow through the second purification column R2 under the pushing action of the first peristaltic pump, eluting residual impurities on the second purification column, and enabling waste liquid to enter the third waste liquid bottle X9.
And 8, closing the third pinch valve C3 and the ninth pinch valve C9, opening the second pinch valve C2 and the tenth pinch valve C10, enabling hydrochloric acid in the second raw material bottle X2 to flow through the second purifying column R2 under the pushing action of the first peristaltic pump, eluting zirconium 89 (89 ZR) on the purifying column, reacting to obtain zirconium chloride, and entering the second product bottle X10.
In each of the above steps, the pinch valve, which is not mentioned, is in a closed state by default. The automatic control of the steps 1 to 8 can be realized by utilizing software programming through the control connection of the controller with each control valve, the three-way valve and the power pump.
According to the invention, by adopting a mode of connecting two stages of resins in series, various elements and nuclides in the target material irradiated on the cyclotron can be separated through program control, a user can select and obtain a product zirconium oxalate or a product zirconium chloride according to the requirement of subsequent drug labeling, and the system can be directly used for radionuclide zirconium 89 of drug labeling after separation and purification. Peristaltic pumps are used as power devices in the system, pinch valves control on-off of each pipeline, and liquid produced in each step is split into corresponding collecting bottles. After program control, one-key start can be realized, and a complete multifunctional purification 89ZR system is formed.
The invention is used for purification, the integral purification and separation time is 35min, the recovery rate of the zirconium 89 nuclide product is more than 95%, the purity of the zirconium 89 radionuclide is more than 99.9%, the metallic impurity copper and zinc is less than 1ug/GBq, and the metallic impurity yttrium is less than 5ug/GBq (Ji Beike).
The invention can not only meet the separation and purification process of 89ZR production by a matched cyclotron, but also provide two purified products, namely zirconium oxalate or zirconium chloride for users, and solve the problem of single product. Meanwhile, the irradiation damage can be reduced by full-automatic operation and full-process, the purification time is shortened, and the purification efficiency of 89ZR is improved.
The foregoing description of the preferred embodiments of the present invention is not obvious contradiction or on the premise of a certain preferred embodiment, but all the preferred embodiments can be used in any overlapped combination, and the embodiments and specific parameters in the embodiments are only for clearly describing the invention verification process of the inventor and are not intended to limit the scope of the invention, and the scope of the invention is still subject to the claims, and all equivalent structural changes made by applying the specification and the content of the drawings of the present invention are included in the scope of the invention.
Claims (6)
1. The hydrochloric acid oxalic acid double-system purification system of the radionuclide 89Zr is characterized by comprising a first power pump, a first three-way pipe, a second three-way pipe and a third three-way pipe which are connected in series with a first interface of the first power pump, wherein the first three-way pipe, the second three-way pipe and the third three-way pipe are also respectively connected with a first raw material bottle, a second raw material bottle and a third raw material bottle, and the third three-way pipe is also connected with a fourth raw material bottle;
The second interface of the first power pump is connected with a first three-way valve, the other two interfaces of the first three-way valve are respectively connected with a second three-way valve and a first purification column, the other interface of the first purification column is connected with a fourth three-way pipe, a fifth three-way pipe and a sixth three-way pipe in series, wherein the fourth three-way pipe, the fifth three-way pipe and the sixth three-way pipe are also respectively connected with a first waste liquid bottle, a second waste liquid bottle and a third waste liquid bottle, and the sixth three-way pipe is also connected with a first product bottle;
the first product bottle is connected with a second three-way valve through a second power pump, the second three-way valve is also connected with a second purification column, the other interface of the second purification column is connected with a seventh three-way pipe, and the seventh three-way pipe is also connected with a third waste liquid bottle and a second product bottle;
control valves are connected between the three-way pipe and the raw material bottle, between the three-way pipe and the waste liquid bottle and between the three-way pipe and the product bottle, and the first purifying column is ZR resin and the second purifying column is QMA resin.
2. The radionuclide 89Zr hydrochloric acid oxalic acid dual system purification system of claim 1, wherein the power pump is a peristaltic pump.
3. The radionuclide 89Zr hcl oxalic acid dual system purification system of claim 1, wherein the control valve is a pinch valve.
4. The radionuclide 89Zr hcl oxalic acid dual system purification system of claim 1, further comprising a controller in control connection with each of the three-way valve, the control valve, and the power pump.
5. A method for purifying a radionuclide 89Zr oxalic acid hydrochloride by a two-system purification system according to any one of claims 1-4, comprising the steps of:
step 1, firstly, a first three-way valve F1 is regulated to be communicated with a first power pump P1 and a first purification column, then a first control valve and a fifth control valve are opened, the first power pump and other pinch valves are closed;
under the pushing action of the first power pump, the target water dissolved in the first raw material bottle flows through the first purification column through the pipeline, the target object is adsorbed by the first purification column, and the waste liquid enters the first waste liquid bottle;
The target water is a liquid containing zirconium 89 ions;
Step 2, closing the first control valve and the fifth control valve, opening the second control valve and the sixth control valve, enabling hydrochloric acid liquid in the second raw material bottle to flow through the first purification column by virtue of the first power pump under the pushing action, eluting target material impurities remained on the purification column, and enabling waste liquid to enter the second waste liquid bottle;
And 3, closing the second control valve and the sixth control valve. Opening a third control valve and a seventh control valve, enabling liquid water in the third raw material bottle to flow through the first purification column by virtue of the pushing action of the first power pump, eluting impurities remained on the purification column, and enabling waste liquid to enter a third waste liquid bottle;
Step 4, closing the third control valve, the seventh control valve, opening the fourth control valve and the eighth control valve, enabling oxalic acid solution in the fourth raw material bottle to flow through the first purification column through the pipeline under the pushing action of the first power pump, eluting 89ZR on the first purification column, and entering the first product bottle;
Obtaining a product zirconium oxalate 89 solution obtained after elution and oxalic acid reaction in a first product bottle;
step 5, closing the fourth control valve, the eighth control valve and the first power pump;
step 6, the second three-way valve is regulated to be communicated with the second power pump P2 and the second purifying column R2 only, the second power pump and the ninth control valve are opened, and under the pushing action of the second power pump, the zirconium oxalate 89 solution in the first product bottle flows through the second purifying column and enters the third waste liquid bottle, and the second purifying column is QMA resin;
step 7, closing the second power pump, and adjusting the first three-way valve and the second three-way valve to the state that the second three-way valve is only communicated with the first three-way valve and the seventh three-way pipe, wherein the first three-way valve is also connected with the first power pump;
Opening a third control valve and a first power pump, enabling water in a third raw material bottle to flow through a second purification column under the pushing action of the first power pump, eluting residual impurities on the second purification column, and enabling waste liquid to enter a third waste liquid bottle;
And 8, closing a third control valve and a ninth control valve, opening a second control valve and a tenth control valve, enabling hydrochloric acid in the second raw material bottle to flow through the second purification column under the pushing action of the first power pump, eluting 89ZR on the purification column, reacting to obtain zirconium chloride, and entering a second product bottle.
6. The method for purifying the radionuclide 89Zr hydrochloric acid oxalic acid double system according to claim 5, wherein the preparation method of the target water in the first raw material bottle is as follows: the yttrium 89 is continuously bombarded by protons to prepare a target slice, after the bombardment is performed for more than 3 hours, 6 mol/L HCl is used for dissolving to obtain target water, and the mass volume ratio of the target slice to the hydrochloric acid solution is 0.8-2 ml corresponding to each 100 mg of target slice.
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