JP4792431B2 - Cadmium-112 isotope recovery method - Google Patents
Cadmium-112 isotope recovery method Download PDFInfo
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- JP4792431B2 JP4792431B2 JP2007170278A JP2007170278A JP4792431B2 JP 4792431 B2 JP4792431 B2 JP 4792431B2 JP 2007170278 A JP2007170278 A JP 2007170278A JP 2007170278 A JP2007170278 A JP 2007170278A JP 4792431 B2 JP4792431 B2 JP 4792431B2
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Description
本発明は、カドミウム−１１２同位元素の回収方法に関し、特に、カドミウム−１１２ターゲット材料の化学分離液や電気メッキ液の残留液から、水酸化物と反応して、水酸化カドミウム沈殿物を生成し、また、濾過して洗浄することにより、カドミウム−１１２同位元素を回収できる方法に関する。 The present invention relates to a method for recovering cadmium-112 isotope, and in particular, reacts with a hydroxide from a chemical separation liquid of a cadmium-112 target material or a residual liquid of an electroplating liquid to generate a cadmium hydroxide precipitate. In addition, the present invention relates to a method capable of recovering the cadmium-112 isotope by filtration and washing.
インジウム−１１１放射性同位元素の核子特性は、電子を捕獲して、二つのガンマ線特性エネルギースペクトルを釈放し、その半減期が短くエネルギーが適当であるため、人体器官病理変化の診断や生理機能研究のために、幅広く核医学単光子放出計算機トモグラフィー（Ｓｉｎｇｌｅ Ｐｈｏｔｏｎ Ｅｍｉｓｓｉｏｎ Ｃｏｍｐｕｔｅｒｉｚｅｄ Ｔｏｍｏｇｒａｐｈｙ、ＳＰＥＣＴ）に適用される。 The nucleon characteristics of indium-111 radioisotope capture electrons, release two gamma-ray energy spectrums, and have a short half-life and are suitable for energy. Therefore, it is widely applied to single photon emission computed tomography (SPECT).
インジウム−１１１の標識化合物は、例えば、１１１ＩｎＣｌ３、１１１Ｉｎ−ｂｌｅｏｍｙｓｉｎ及び１１１Ｉｎ−ＤＴＰＡ（オクトレオチド）で、器官の局部腫瘍を鑑定することに適用でき、また、１１１Ｉｎ−Ｏｘｉｎｅ脂肪親和性錯化合物は、白血球を標識して膿瘍の造影や炎症等の病変を診断でき、また、１１１Ｉｎや単クローン抗体、血小板、グロブリン、巨大分子γｔ−ＰＡ（ｒｅｃｏｍｂｉｎａｎｔ ｔｉｓｓｕｅ ｐｌａｓｍｉｎｏｇｅｎ ａｃｔｉｖａｔｏｒ）或いはＦａｂ、（Ｆａｂ｀）２ （ｉｍｍｕｎｏｇｌｏｂｕｌｉｎ ｆｒａｇｍｅｎｔｓ）等により形成された錯化合物は、応用可能性が非常に高いイメージング剤であり、心筋梗塞や血栓の正しい位置を走査でき、また、トロンビンや腎機能等の生理研究に適用できる。 Labeled compounds of indium-111 are, for example, 111InCl3, 111In-bleomycin and 111In-DTPA (octreotide), which can be applied to identify local tumors of organs, and 111In-Oxine lipophilic complex compounds can be used to identify leukocytes. Labeling allows diagnosis of lesions such as abscess imaging and inflammation, and 111In, monoclonal antibodies, platelets, globulins, macromolecules γt-PA (recombinant tissue plasma activator) or Fab, (Fab ｀) 2 (immunoglobulin fragments) The complex compound formed by the above is an imaging agent with very high applicability, and can scan the correct position of myocardial infarction and thrombus, and can also be applied to physiological studies such as thrombin and renal function Kill.
インジウム−１１１同位元素の主な生産経路は、１１２Ｃｄ（ｐ、２ｎ）や１１１Ｃｄ（ｐ、ｎ）、ｎａｔＣｄ（ｐ、ｘｎ）、１１０Ｃｄ（ｄ、ｎ）及び１０９Ａｇ（α、２ｎ）等があり、その中、同位体濃縮１１２Ｃｄ（９７％）固体ターゲットを利用して、適当なターゲットの厚さ（〜１００μｍ）と陽子線エネルギー（〜２２ＭｅＶ）の条件で、１１１Ｉｎ最大の産出高が得られる。 The main production paths of indium-111 isotopes are 112Cd (p, 2n), 111Cd (p, n), natCd (p, xn), 110Cd (d, n), 109Ag (α, 2n), etc. Among them, by using an isotope-enriched 112Cd (97%) solid target, the maximum yield of 111In can be obtained under conditions of an appropriate target thickness (˜100 μm) and proton beam energy (˜22 MeV).
核医学製薬センターにおいて、サイクロトロンにより核医学薬品であるオクトレオチド（インジウム−１１１）を作製し、わが国では、類似する同位元素を作製できず、毎年に核医学薬品であるオクトレオチド（インジウム−１１１）を生産するため、海外から濃縮カドミウム−１１２同位元素を輸入し、手に入れることが容易ではない。それは、至急に解決しなければならない課題である。 At the Nuclear Medicine Pharmaceutical Center, octreotide (indium-111), a nuclear medicine, was produced by cyclotron. In Japan, octreotide (indium-111), a nuclear medicine, cannot be produced every year. Therefore, it is not easy to import and obtain concentrated cadmium-112 isotopes from overseas. It is a problem that must be solved urgently.
本発明の主な目的は、原料費用の節約とコストの低下ができ、回収率が高く、高い純度のカドミウム−１１２同位元素が得られるカドミウム−１１２同位元素の回収方法を提供する。 The main object of the present invention is to provide a method for recovering cadmium-112 isotopes, which can save raw material costs and reduce costs, has a high recovery rate, and provides high-purity cadmium-112 isotopes.
本発明は、上記の目的を達成するため、硫化物溶液を、カドミウム−１１２ターゲット材料電気メッキ液の残留液（シアン化水素などの酸や水酸化ナトリウムなどのアルカリも含む）に添加して、硫化カドミウム沈殿物を生成し、また、該硫化カドミウム沈殿物を塩酸に溶解して塩化カドミウム溶液を形成し、そして、水酸化物溶液を混合し、水酸化カドミウム沈殿物を生成し、最後に、該水酸化カドミウム沈殿物について、濾過して洗浄し、カドミウム−１１２同位元素を回収するカドミウム−１１２同位元素の回収方法である。 In order to achieve the above object, the present invention adds a sulfide solution to a residual solution of an electroplating solution of a cadmium-112 target material (including an acid such as hydrogen cyanide and an alkali such as sodium hydroxide), and cadmium sulfide. A cadmium chloride solution is formed by dissolving the cadmium sulfide precipitate in hydrochloric acid to form a cadmium chloride solution, and a hydroxide solution is mixed to form a cadmium hydroxide precipitate; This is a method for recovering a cadmium-112 isotope in which the cadmium oxide precipitate is filtered and washed to recover the cadmium-112 isotope.
また、本発明は、カドミウム−１１２ターゲット材料化学分離液（シアン化水素などの酸や水酸化ナトリウムなどのアルカリも含む）と臭素化カドミウム溶液とを混合することにより、混合液が形成され、また、水酸化物溶液を該混合液に混合して撹拌することにより、水酸化カドミウム沈殿物を生成し、最後に、該水酸化カドミウム沈殿物を濾過して洗浄し、カドミウム−１１２同位元素を回収してもよい。 In addition, the present invention provides a cadmium-112 target material chemical separation liquid (including an acid such as hydrogen cyanide and an alkali such as sodium hydroxide) and a cadmium bromide solution to form a mixed liquid, The oxide solution is mixed with the mixture and stirred to form a cadmium hydroxide precipitate. Finally, the cadmium hydroxide precipitate is filtered and washed to recover the cadmium-112 isotope. Also good.
図１と図２は、本発明の第１の実施例の流れの概念図と本発明の第２の実施例の流れの概念図である。図のように、本発明は、カドミウム−１１２同位元素の回収方法であり、カドミウム−１１２ターゲット材料電気メッキ液の残留液（シアン化水素などの酸や水酸化ナトリウムなどのアルカリも含む）やカドミウム−１１２ターゲット材料化学分離液（シアン化水素などの酸や水酸化ナトリウムなどのアルカリも含む）から、カドミウム−１１２同位元素を回収することができ、また、カドミウム−１１２ターゲット材料電気メッキ液の残留液から、回収する方法は、少なくとも、次のステップが備えられる。 1 and 2 are a conceptual diagram of the flow of the first embodiment of the present invention and a conceptual diagram of the flow of the second embodiment of the present invention. As shown in the figure, the present invention is a method for recovering the cadmium-112 isotope. The cadmium-112 target material electroplating solution residual liquid (including an acid such as hydrogen cyanide and an alkali such as sodium hydroxide) or cadmium-112. Cadmium-112 isotopes can be recovered from the target material chemical separation liquid (including acids such as hydrogen cyanide and alkalis such as sodium hydroxide) , and recovered from the residual cadmium-112 target material electroplating liquid. The method of performing at least the following steps.
ステップ（Ａ１）は、硫化カドミウム沈殿物１１を生成し、硫化物溶液をカドミウム−１１２ターゲット材料電気メッキ液の残留液に添加することにより、硫化カドミウム沈殿物を生成し、また、該硫化物溶液は、硫化ナトリウム溶液である。 In step (A1), a cadmium sulfide precipitate 11 is generated, and the cadmium sulfide precipitate is generated by adding the sulfide solution to the residual liquid of the cadmium-112 target material electroplating solution. Is a sodium sulfide solution.
ステップ（Ｂ１）は、塩化カドミウム溶液１２を形成し、該硫化カドミウム沈殿物を、塩酸に溶解することにより、塩化カドミウム溶液を形成する。 Step (B1) forms a cadmium chloride solution 12, the sulfuric cadmium precipitate, by dissolving in hydrochloric acid, to form a cadmium chloride solution.
ステップ（Ｃ１）は、水酸化カドミウム沈殿物１３を生成し、該塩化カドミウム溶液を水酸化物溶液に混合することにより、水酸化カドミウム沈殿物を生成し、また、該水酸化物溶液は、水酸化カリウム溶液や水酸化ナトリウム溶液である。 Step (C1) generates a cadmium hydroxide precipitate 13, by mixing the cadmium chloride solution to the hydroxide solution to produce a cadmium hydroxide precipitate, also, the hydroxide solution, water A potassium oxide solution or a sodium hydroxide solution.
ステップ（Ｄ１）は、カドミウム−１１２同位元素１４を回収し、該水酸化カドミウム沈殿物を半自動化真空ろ過システムに移入し、濾過と洗浄を行ってカドミウム−１１２同位元素を回収する。 Step (D1) collects the cadmium-112 isotope 14, transfers the cadmium hydroxide precipitate to a semi-automated vacuum filtration system, performs filtration and washing, and collects the cadmium-112 isotope.
また、本発明は、カドミウム−１１２ターゲット材料化学分離液から回収する方法は、少なくとも、次のステップが備えられる。 In addition, according to the present invention, the method for recovering from the cadmium-112 target material chemical separation liquid includes at least the following steps.
ステップ（Ａ２）は、混合液２１を形成し、カドミウム−１１２ターゲット材料化学分離液と臭素化カドミウム溶液を混合することにより、混合液を形成する。 Step (A2) forms the liquid mixture 21 by forming the liquid mixture 21 and mixing the cadmium-112 target material chemical separation liquid and the cadmium bromide solution.
ステップ（Ｂ２）は、水酸化カドミウム沈殿物２２を生成し、水酸化物溶液を上記の混合液に混合して撹拌することにより、水酸化カドミウム沈殿物を生成し、また、該水酸化物溶液は、水酸化カリウム溶液や水酸化ナトリウム溶液である。 In step (B2), a cadmium hydroxide precipitate 22 is generated, and the hydroxide solution is mixed with the above mixed solution and stirred to generate a cadmium hydroxide precipitate, and the hydroxide solution Is a potassium hydroxide solution or a sodium hydroxide solution.
ステップ（Ｃ２）は、カドミウム−１１２同位元素２３を形成し、該水酸化カドミウム沈殿物を半自動化真空ろ過システムに移入して、濾過と洗浄を行ってカドミウム−１１２同位元素を回収する。 Step (C2) forms cadmium-112 isotope 23, transfers the cadmium hydroxide precipitate to a semi-automated vacuum filtration system, and performs filtration and washing to recover the cadmium-112 isotope.
上記の２種類の方法により回収されたカドミウム−１１２同位元素は、か焼により、固体酸化カドミウムになり、或いは、シアン化物溶液とアルカリ性溶液に溶解してカドミウム−１１２ターゲット材料電気メッキ液を形成し、該カドミウム−１１２同位元素の回収率が、９８％以上まで上り、純度が９９％程度になり、また保管が容易である。 The cadmium-112 isotope recovered by the above two methods becomes solid cadmium oxide by calcination, or dissolves in a cyanide solution and an alkaline solution to form a cadmium-112 target material electroplating solution. The cadmium-112 isotope recovery rate increases to 98% or more, the purity is about 99%, and storage is easy.
以上のように、本発明に係わるカドミウム−１１２同位元素の回収方法は、カドミウム−１１２同位元素を回収してリサイクルでき、その回収率と純度が９８％以上で、原料費用や核医学製薬コストを節約できるため、本発明は、より進歩的かつより実用的で、法に従って特許請求を出願する。 As described above, the method for recovering the cadmium-112 isotope according to the present invention can recover and recycle the cadmium-112 isotope, and the recovery rate and purity are 98% or more, and the raw material costs and nuclear medicine costs are reduced. Because of the savings, the present invention is more progressive and more practical, and claims are filed according to law.
以上は、ただ、本発明のより良い実施例であり、本発明はそれによって制限されることが無く、本発明に係わる特許請求の範囲や明細書の内容に基づいて行った等価の変更や修正は、全てが本発明の特許請求の範囲内に含まれる。 The above are merely preferred embodiments of the present invention, and the present invention is not limited thereby. Are all within the scope of the claims of the present invention.
１１ ステップ（Ａ１）
１２ ステップ（Ｂ１）
１３ ステップ（Ｃ１）
１４ ステップ（Ｄ１）
２１ ステップ（Ａ２）
２２ ステップ（Ｂ２）
２３ ステップ（Ｃ２）
11 steps (A1)
12 steps (B1)
13 steps (C1)
14 steps (D1)
21 Step (A2)
22 steps (B2)
23 Step (C2)
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| JP2007170278A JP4792431B2 (en) | 2007-06-28 | 2007-06-28 | Cadmium-112 isotope recovery method |
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| JP2007170278A JP4792431B2 (en) | 2007-06-28 | 2007-06-28 | Cadmium-112 isotope recovery method |
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| JP2009007633A JP2009007633A (en) | 2009-01-15 |
| JP4792431B2 true JP4792431B2 (en) | 2011-10-12 |
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| JP2007170278A Expired - Fee Related JP4792431B2 (en) | 2007-06-28 | 2007-06-28 | Cadmium-112 isotope recovery method |
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| US8043584B2 (en) * | 2007-06-22 | 2011-10-25 | Atomic Energy Council - Institute Of Nuclear Energy Research | Method of recycling Cd-112 isotope |
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