TW202313039A - Pm14用途與方案 - Google Patents

Pm14用途與方案 Download PDF

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Publication number
TW202313039A
TW202313039A TW111118548A TW111118548A TW202313039A TW 202313039 A TW202313039 A TW 202313039A TW 111118548 A TW111118548 A TW 111118548A TW 111118548 A TW111118548 A TW 111118548A TW 202313039 A TW202313039 A TW 202313039A
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TW
Taiwan
Prior art keywords
compound
dose
cancer
administered
salt
Prior art date
Application number
TW111118548A
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English (en)
Chinese (zh)
Inventor
卡門 卡哈特
皮拉爾 拉爾戴利
克利斯提安 費南德茲
阿圖羅 蘇妥
Original Assignee
西班牙商瑪製藥股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 西班牙商瑪製藥股份有限公司 filed Critical 西班牙商瑪製藥股份有限公司
Publication of TW202313039A publication Critical patent/TW202313039A/zh

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D515/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995Pyrazines or piperazines forming part of bridged ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW111118548A 2021-05-19 2022-05-19 Pm14用途與方案 TW202313039A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP21382455.0 2021-05-19
EP21382455 2021-05-19

Publications (1)

Publication Number Publication Date
TW202313039A true TW202313039A (zh) 2023-04-01

Family

ID=76197383

Family Applications (1)

Application Number Title Priority Date Filing Date
TW111118548A TW202313039A (zh) 2021-05-19 2022-05-19 Pm14用途與方案

Country Status (11)

Country Link
US (1) US20240277705A1 (https=)
EP (1) EP4340841A1 (https=)
JP (1) JP2024521122A (https=)
KR (1) KR20240009437A (https=)
CN (1) CN117295499A (https=)
AU (1) AU2022277799A1 (https=)
CA (1) CA3218171A1 (https=)
IL (1) IL308389A (https=)
MX (1) MX2023013715A (https=)
TW (1) TW202313039A (https=)
WO (1) WO2022243482A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4563149A1 (en) * 2023-11-30 2025-06-04 Pharma Mar, S.A. Lurbinectedin, ecubectedin and a related compound for use in the treatment of skin cancers
WO2025168075A1 (zh) * 2024-02-08 2025-08-14 映恩生物科技(上海)有限公司 海鞘素类化合物及其应用
TW202547489A (zh) 2024-04-30 2025-12-16 西班牙商瑪製藥股份有限公司 化合物ia於包括與阿替利珠單抗的組合療法之癌症的治療中之用途
WO2025228596A1 (en) 2024-04-30 2025-11-06 Pharma Mar, S.A. Combination of pm14 and a topoisomerase i inhibitor in the treatment of cancer
WO2025228594A1 (en) 2024-04-30 2025-11-06 Pharma Mar, S.A. Use of ecubectedin in the treatment of cancers including combination therapy with atezolizumab

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE368461T1 (de) * 2004-10-29 2007-08-15 Pharma Mar Sa Zusammensetzungen enthaltend ecteinascidin und einen disaccharide
KR102491180B1 (ko) 2017-04-27 2023-01-20 파르마 마르 에스.에이. 항종양 화합물
TWI824043B (zh) * 2018-10-25 2023-12-01 西班牙商瑪製藥股份有限公司 藥物抗體共軛物

Also Published As

Publication number Publication date
JP2024521122A (ja) 2024-05-28
US20240277705A1 (en) 2024-08-22
CA3218171A1 (en) 2022-11-24
CN117295499A (zh) 2023-12-26
EP4340841A1 (en) 2024-03-27
WO2022243482A1 (en) 2022-11-24
MX2023013715A (es) 2024-03-26
KR20240009437A (ko) 2024-01-22
AU2022277799A1 (en) 2023-12-21
IL308389A (en) 2024-01-01

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