TW202313038A - 用於治療晚期實性瘤之fgfr酪胺酸激酶抑制劑 - Google Patents

用於治療晚期實性瘤之fgfr酪胺酸激酶抑制劑 Download PDF

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Publication number
TW202313038A
TW202313038A TW111118772A TW111118772A TW202313038A TW 202313038 A TW202313038 A TW 202313038A TW 111118772 A TW111118772 A TW 111118772A TW 111118772 A TW111118772 A TW 111118772A TW 202313038 A TW202313038 A TW 202313038A
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Taiwan
Prior art keywords
fgfr2
cancer
fgfr
carcinoma
fgfr3
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TW111118772A
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English (en)
Chinese (zh)
Inventor
克里斯多福 莫伊
沃克 艾黛美 聖地牙哥
麥可 舒弗
胡森 史威帝
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比利時商健生藥品公司
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Publication of TW202313038A publication Critical patent/TW202313038A/zh

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW111118772A 2021-05-19 2022-05-19 用於治療晚期實性瘤之fgfr酪胺酸激酶抑制劑 TW202313038A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US202163190602P 2021-05-19 2021-05-19
US63/190,602 2021-05-19
US202163242857P 2021-09-10 2021-09-10
US63/242,857 2021-09-10
US202163253316P 2021-10-07 2021-10-07
US63/253,316 2021-10-07

Publications (1)

Publication Number Publication Date
TW202313038A true TW202313038A (zh) 2023-04-01

Family

ID=82067489

Family Applications (1)

Application Number Title Priority Date Filing Date
TW111118772A TW202313038A (zh) 2021-05-19 2022-05-19 用於治療晚期實性瘤之fgfr酪胺酸激酶抑制劑

Country Status (9)

Country Link
EP (1) EP4340840A1 (ja)
JP (1) JP2024518612A (ja)
KR (1) KR20240009465A (ja)
AU (1) AU2022277796A1 (ja)
BR (1) BR112023023935A2 (ja)
CA (1) CA3217517A1 (ja)
MX (1) MX2023013802A (ja)
TW (1) TW202313038A (ja)
WO (1) WO2022243467A1 (ja)

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4801531A (en) 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
US6218529B1 (en) 1995-07-31 2001-04-17 Urocor, Inc. Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer
CA2262403C (en) 1995-07-31 2011-09-20 Urocor, Inc. Biomarkers and targets for diagnosis, prognosis and management of prostate disease
GB0512324D0 (en) 2005-06-16 2005-07-27 Novartis Ag Organic compounds
WO2006127926A2 (en) 2005-05-23 2006-11-30 Novartis Ag Crystalline and other forms of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]-1h-quinolin-2-one lactic acid salts
US8163923B2 (en) 2007-03-14 2012-04-24 Advenchen Laboratories, Llc Spiro substituted compounds as angiogenesis inhibitors
GB201007286D0 (en) 2010-04-30 2010-06-16 Astex Therapeutics Ltd New compounds
DK3125936T3 (da) * 2014-03-31 2019-08-05 Debiopharm Int Sa Fgfr-fusioner
LT3198033T (lt) * 2014-09-26 2022-05-10 Janssen Pharmaceutica Nv Fgfr mutantinių genų rinkinių panaudojimas identifikuojant vėžiu sergančius pacientus, kurie reaguos į gydymą fgfr inhibitoriumi
US20200208224A1 (en) * 2014-09-26 2020-07-02 Janssen Pharmaceutica Nv Use Of FGFR Mutant Gene Panels In Identifying Cancer Patients That Will Be Responsive To Treatment With An FGFR Inhibitor
EA202193276A1 (ru) * 2019-05-28 2022-03-29 Квед Терапьютикс, Инк. Способы лечения холангиокарциномы

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Publication number Publication date
JP2024518612A (ja) 2024-05-01
CA3217517A1 (en) 2022-11-24
AU2022277796A1 (en) 2024-01-18
KR20240009465A (ko) 2024-01-22
BR112023023935A2 (pt) 2024-01-30
WO2022243467A1 (en) 2022-11-24
EP4340840A1 (en) 2024-03-27
MX2023013802A (es) 2023-12-06

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