TW202305135A - 用於抑制己酮醣激酶（khk）之組合物及方法 - Google Patents
用於抑制己酮醣激酶（khk）之組合物及方法 Download PDFInfo
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| CA3211059A1 (en) * | 2021-02-26 | 2022-09-01 | Alnylam Pharmaceuticals, Inc. | Ketohexokinase (khk) irna compositions and methods of use thereof |
| TW202430191A (zh) | 2022-10-11 | 2024-08-01 | 德商百靈佳殷格翰國際股份有限公司 | 用於治療伴有晚期纖維化及/或硬化之nash的方法 |
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| CN118703500B (zh) * | 2024-01-30 | 2025-06-17 | 大连医科大学 | 一种果糖激酶khk的小干扰和短发夹rna序列组合及其应用 |
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| US5977343A (en) | 1992-05-14 | 1999-11-02 | Ribozyme Pharmaceuticals, Inc. | Synthesis, deprotection, analysis and purification of RNA and ribozymes |
| US5804683A (en) | 1992-05-14 | 1998-09-08 | Ribozyme Pharmaceuticals, Inc. | Deprotection of RNA with alkylamine |
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| KR20080023768A (ko) | 2000-03-30 | 2008-03-14 | 화이트헤드 인스티튜트 포 바이오메디칼 리서치 | Ｒｎａ 간섭의 ｒｎａ 서열 특이적인 매개체 |
| CN100523215C (zh) | 2000-12-01 | 2009-08-05 | 马普科技促进协会 | 介导rna干涉的小rna分子 |
| US20050159378A1 (en) | 2001-05-18 | 2005-07-21 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of Myc and/or Myb gene expression using short interfering nucleic acid (siNA) |
| WO2003040395A2 (en) | 2001-11-07 | 2003-05-15 | Applera Corporation | Universal nucleotides for nucleic acid analysis |
| US20070265220A1 (en) | 2004-03-15 | 2007-11-15 | City Of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA |
| WO2007030167A1 (en) | 2005-09-02 | 2007-03-15 | Nastech Pharmaceutical Company Inc. | Modification of double-stranded ribonucleic acid molecules |
| WO2010033225A2 (en) | 2008-09-22 | 2010-03-25 | Dicerna Pharmaceuticals, Inc. | Compositions and methods for the specific inhibition of gene expression by dsrna possessing modifications |
| KR20110110776A (ko) | 2008-12-18 | 2011-10-07 | 다이서나 파마수이티컬, 인크. | 유전자 발현의 특이적 억제를 위한 연장된 다이서 기질 제제 및 방법 |
| WO2010093788A2 (en) | 2009-02-11 | 2010-08-19 | Dicerna Pharmaceuticals, Inc. | Multiplex dicer substrate rna interference molecules having joining sequences |
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| AU2012328680A1 (en) | 2011-10-25 | 2014-05-01 | Ionis Pharmaceuticals, Inc. | Antisense modulation of GCCR expression |
| EP3105331B1 (en) * | 2014-02-11 | 2021-06-23 | Alnylam Pharmaceuticals, Inc. | Ketohexokinase (khk) irna compositions and methods of use thereof |
| US10351854B2 (en) * | 2014-10-10 | 2019-07-16 | Dicerna Pharmaceuticals, Inc. | Therapeutic inhibition of lactate dehydrogenase and agents therefor |
| EP3865576A1 (en) * | 2014-12-15 | 2021-08-18 | Dicerna Pharmaceuticals, Inc. | Ligand-modified double-stranded nucleic acids |
| WO2018045317A1 (en) * | 2016-09-02 | 2018-03-08 | Dicerna Pharmaceuticals, Inc. | 4'-phosphate analogs and oligonucleotides comprising the same |
| EP3684377B1 (en) * | 2017-10-20 | 2022-12-07 | Dicerna Pharmaceuticals, Inc. | Methods for treating hepatitis b infection |
| JP2022500003A (ja) * | 2018-09-18 | 2022-01-04 | アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. | ケトヘキソキナーゼ（ＫＨＫ）ｉＲＮＡ組成物およびその使用方法 |
| US20220389430A1 (en) * | 2019-10-02 | 2022-12-08 | Dicema Pharmaceuticals, Inc. | Chemical modifications of small interfering rna with minimal fluorine content |
| MX2022011009A (es) * | 2020-03-06 | 2022-10-07 | Alnylam Pharmaceuticals Inc | Composiciones de acido ribonucleico de interferencia (arni) de ketohexocinasa (khk) y metodos de uso de las mismas. |
| CA3211059A1 (en) * | 2021-02-26 | 2022-09-01 | Alnylam Pharmaceuticals, Inc. | Ketohexokinase (khk) irna compositions and methods of use thereof |
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- 2022-04-11 WO PCT/EP2022/059663 patent/WO2022218941A2/en not_active Ceased
- 2022-04-11 CN CN202280027703.6A patent/CN117120612A/zh active Pending
- 2022-04-11 TW TW111113704A patent/TW202305135A/zh unknown
- 2022-04-11 PE PE2023002847A patent/PE20250400A1/es unknown
- 2022-04-11 EP EP22719944.5A patent/EP4323518A2/en not_active Withdrawn
- 2022-04-11 JP JP2023562314A patent/JP2024516356A/ja not_active Abandoned
- 2022-04-11 PH PH1/2023/552830A patent/PH12023552830A1/en unknown
- 2022-04-11 CR CR20230482A patent/CR20230482A/es unknown
- 2022-04-11 KR KR1020237038934A patent/KR20230170732A/ko active Pending
- 2022-04-11 AU AU2022256742A patent/AU2022256742A1/en not_active Withdrawn
- 2022-04-11 BR BR112023017367A patent/BR112023017367A2/pt not_active Application Discontinuation
- 2022-04-11 CA CA3214439A patent/CA3214439A1/en active Pending
- 2022-04-11 US US17/717,174 patent/US20220340909A1/en not_active Abandoned
- 2022-04-11 IL IL307315A patent/IL307315A/en unknown
-
2023
- 2023-10-10 CL CL2023003017A patent/CL2023003017A1/es unknown
- 2023-10-11 EC ECSENADI202376906A patent/ECSP23076906A/es unknown
- 2023-10-11 CO CONC2023/0013465A patent/CO2023013465A2/es unknown
- 2023-10-11 DO DO2023000223A patent/DOP2023000223A/es unknown
- 2023-10-12 JO JOJO/P/2023/0250A patent/JOP20230250A1/ar unknown
-
2024
- 2024-04-22 US US18/641,868 patent/US20250092403A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20220340909A1 (en) | 2022-10-27 |
| IL307315A (en) | 2023-11-01 |
| BR112023017367A2 (pt) | 2023-12-12 |
| CL2023003017A1 (es) | 2024-05-03 |
| DOP2023000223A (es) | 2023-11-15 |
| US20250092403A1 (en) | 2025-03-20 |
| JP2024516356A (ja) | 2024-04-15 |
| KR20230170732A (ko) | 2023-12-19 |
| MX2023012048A (es) | 2023-10-23 |
| WO2022218941A2 (en) | 2022-10-20 |
| PE20250400A1 (es) | 2025-02-11 |
| CR20230482A (es) | 2023-12-07 |
| WO2022218941A3 (en) | 2023-02-23 |
| PH12023552830A1 (en) | 2024-05-20 |
| JOP20230250A1 (ar) | 2023-10-12 |
| CN117120612A (zh) | 2023-11-24 |
| EP4323518A2 (en) | 2024-02-21 |
| CO2023013465A2 (es) | 2023-10-30 |
| CA3214439A1 (en) | 2022-10-20 |
| ECSP23076906A (es) | 2023-11-30 |
| AU2022256742A1 (en) | 2023-09-07 |
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