TW202302064A - Liposome composition - Google Patents

Abstract

To provide a liposome composition in which crystal deposition of ceramides and sterols is suppressed, which provides moisturizing effects via excellent moisture enclosing properties and excellent stability over time (effect of suppressing crystal deposition of ceramides and phytosterols, stability of the liposome composition) in a wide range of temperatures, and which provides an excellent sensation of sheen and sensation of resilience. A liposome composition comprising the following components (A) to (D): (A) a phospholipid; (B) a phytosterol; (C) a ceramide; and (D) one or more components (d1) selected from polyalcohols having an IOB value of 1.8-3.5, and/or one or more components (d2) selected from polyalcohols having an IOB value of 4.5-5.5, wherein a value obtained by finding the weighted average of the respective IOB values of the components of (D) on the basis of content mass ratio is greater than 2.0 but less than 5.0.

Description

Liposome composition

The invention relates to a liposome composition.

It is known that human skin will cause various skin troubles with age, for example: dryness or rough skin caused by a decrease in the barrier function of the skin, spots or sagging caused by a decrease in skin elasticity, etc. So far, many technologies and products are being developed. There are technologies to improve the barrier function by applying interkeratinocyte lipids, ceramides or sterols, to the skin; or to impart luster or firmness by forming a film on the skin , to eliminate aging troubles such as spots or sagging products.

Ever since it was clearly known that ceramides or sterols are ingredients that can effectively improve the skin barrier function, attempts have been made to develop moisturizing preparations that incorporate these effective ingredients. However, ceramides and sterols have high crystallinity, and from the standpoint of improving stability and exhibiting moisturizing effects on skin, it is desired to develop cosmetics or external skin preparations that do not cause crystallization. Among them, it is very difficult to stably blend them in an emulsion-based preparation using water as a medium. Therefore, various researches have been conducted on the technique of stably blending such highly crystalline ceramides and sterols into cosmetics in aqueous media.

So far, in order to stably blend ceramides and sterols, a technique of combining ceramides and sterols with straight-chain saturated fatty acids to prepare a liquid crystal composition has been disclosed (see Patent Document 1). Also, as a technique for stabilizing highly crystalline components such as ceramides, a technique of enclosing ceramides in liposomes and having excellent stability in emulsified compositions has been disclosed. The lipid system is formed of phospholipids and polyethylene glycol fatty acid esters (see Patent Document 2).

In addition, for skin whose elasticity decreases due to aging, a technology has been developed that provides a sense of firmness by using oil-soluble and water-soluble film-forming agents, and has an excellent effect of lifting sagging skin. For example, a method for producing The technology of forming oil-in-water emulsified cosmetics is characterized by: blending high-viscosity oil agent, isotridecyl isononanoate and polyethylene glycol (refer to patent Document 3). prior art literature patent documents

Patent Document 1: Japanese Patent Laid-Open No. 2020-109074 Patent Document 2: Japanese Patent Laid-Open No. 2011-32229 Patent Document 3: Japanese Patent Laid-Open No. 2007-261971

However, since the liquid crystal composition disclosed in Patent Document 1 contains straight-chain fatty acids, it may not be able to fully exhibit the moisturizing effect from the viewpoint of safety and compatibility with the skin. In addition, the liquid crystal composition may not be sufficiently stable over time, such as low temperature or temperature cycle, and may not be able to sufficiently exert effects such as moisturizing effect, luster, and firmness.

Also, in the technology disclosed in Patent Document 2, although the stability of ceramides is excellent, the moisturizing effect of ceramides alone may not be sufficient. In addition, the liposome composition may not have sufficient stability over time in a wide range of temperature ranges such as low temperature, temperature cycling, and high temperature, and may not be able to fully exhibit the moisturizing effect, luster, firmness, and other effects.

In the technique disclosed in Patent Document 3, although an improvement in elasticity due to imparting firmness can be observed, the usability such as stickiness and gloss due to the inclusion of a water-soluble film-forming agent may not be sufficient. And sometimes the moisturizing effect cannot be fully exerted.

As mentioned above, in the prior art, the technique of suppressing crystallization in compositions and cosmetics containing ceramides and sterols has been disclosed. However, there are cases where the moisturizing effect is insufficient, and it is difficult to achieve a glossiness. , firmness and other effects. Furthermore, it is assumed that the stability over time in a wide temperature range such as low temperature, temperature cycle, and high temperature may not be sufficient under various usage environments. In addition, although a technique of adding components such as a film-forming agent has been proposed in order to improve glossiness and firmness, there is a concern that the liposome composition may be destabilized by the coexisting components.

That is, the purpose of the present invention is to provide a liposome composition, which can obtain stability over time, especially excellent stability over time (inhibition of ceramides and plant solids) in a wide temperature range such as low temperature, temperature cycling, and high temperature. Alcohol crystallization effect, stability of liposome composition), and moisturizing effect brought by moisture blocking property, and it is also excellent in luster and firmness.

The inventors of the present case have worked hard to solve the above problems and found that by applying a liposome composition containing ceramides and using phytosterols as a component of a lipid bilayer membrane to the skin, in addition to obtaining nerve In addition to the moisturizing effect of amide, since the liposome composition forms a blocking film on the skin to inhibit water evaporation, it can also obtain an excellent moisturizing effect brought by the water blocking property, and it is also known that it has a radiant effect on the skin. Excellent texture and firmness. On the other hand, phytosterols and/or ceramides may dissolve into the coexisting solvent, which may lead to instability of the liposome composition caused by the dissolution of the phytosterol from the liposome composition, and It is extremely difficult to maintain stability over time due to the crystallization of phytosterols and/or ceramides. However, the crystallization of phytosterols and/or ceramides can be suppressed and the dissolution of phytosterols can also be suppressed by making the polarity balance of the polyhydric alcohol contained in the liposome composition within a specific range, and it can be confirmed that Formation of liposome composition with excellent stability over time.

The inventors of the present case have found that combining phospholipids, phytosterols, ceramides and polyols with a specific IOB value, and making the polarity balance of the aforementioned polyols within a specific range, in addition to stability over time (especially in a wide temperature range) In addition to being excellent in stability over time), it is also excellent in usability such as the moisturizing effect brought by the excellent moisture blocking property, the luster, and the firmness, and thus the present invention has been completed.

That is, the present invention provides the following.

[1] A liposome composition, containing the following components (A) ~ (D): (A) phospholipids; (B) phytosterols; (C) ceramides; (D) Component (d1) is selected from one or more polyols with an IOB value of 1.8 to 3.5, and/or component (d2) is selected from one or more polyols with an IOB value of 4.5 to 5.5 2 or more; The weighted average of the IOB values indicated by each component (D) based on the content mass ratio is greater than 2.0 and less than 5.0.

[2] Such as the liposome composition of [1], wherein the mass ratio [(D)/(B)] of component (D) relative to component (B) is 10-60.

[3] The liposome composition of [1] or [2], wherein component (D) contains at least component (d1), and the mass ratio of component (d1) to component (B) is [(d1)/(B)] 10~40.

[4] The liposome composition according to any one of [1] to [3], wherein component (d1) is at least one selected from the group consisting of dipropylene glycol, propylene glycol, and 1,3-butanediol, And the component (d2) is glycerin.

[5] The liposome composition of any one of [1] to [4], wherein component (D) contains component (d1) and component (d2), the content of component (d1) is 3 ~ 20% by mass, component (d2 ) content is 8-15% by mass, and the content mass ratio [(d1)/(d2)] of component (d1) to (d2) is 0.2-2.

[6] The liposome composition according to any one of [1] to [5], wherein the content mass ratio [(A)/(B)] of component (A) to component (B) is 1-30.

[7] The liposome composition according to any one of [1] to [6], wherein the content mass ratio of component (D) relative to the total amount of component (A) and component (B) is [(D)/{(A) +(B)}] is 1~20.

[8] The liposome composition according to any one of [1] to [7], which comprises liposomes obtained by adding an aqueous component to a mixture obtained by mixing components (A) to (D).

[9] A cosmetic or external preparation for skin comprising the liposome composition according to any one of [1] to [8].

[10] The cosmetic or skin external preparation according to [9], which further contains component (E') of one or more kinds selected from organic acids or inorganic acids, and salts thereof (but, as organic acids or inorganic acids system excludes aromatic compounds).

[11] The cosmetic or skin external preparation according to [10], wherein the component (E') is one or more selected from succinic acid and its salts.

[12] The cosmetic or skin external preparation according to any one of [9] to [11], further comprising a component (F') hydrolyzed yeast protein.

In addition, the present invention also provides the following aspects.

[13] The liposome composition according to any one of [1] to [8], wherein the mass ratio [(B)/(C)] of component (B) to component (C) is 1-100.

The liposome composition of the present invention has excellent stability over time in a wide temperature range (the effect of inhibiting the crystallization of ceramides and phytosterols, the stability of the liposome composition), and can obtain excellent Moisturizing effect due to moisture blocking properties. Furthermore, the liposome composition of the present invention is also excellent in luster and firmness.

Embodiments of the present invention will be described below. In addition, this invention is not limited to the following embodiment. In this specification, "X~Y" which shows a range includes X and Y and means "more than X and less than Y".

Also, in this specification, the so-called "liposome composition" means a spherical closed cell body (liposome) containing a lipid bimolecular membrane in an aqueous solvent, and a Maltese cross can be observed under a polarizing microscope. Imager. In addition, the liposome composition preferably includes liposomes, which are obtained by mixing the components required to form liposomes (components (A) to (D) and aqueous components). The liposome composition includes, for example: a liposome formed by adding an aqueous component to a mixture obtained by mixing components (A) to (D).

(ingredient (A): phospholipid) The component (A) phospholipid used in the present invention is contained as a main component of the lipid bilayer forming the liposome composition. The phospholipids are not particularly limited as long as they can be used in general cosmetics, quasi-drugs, drugs, etc., and examples thereof include soybean-derived phospholipids, soybean-derived hydrogenated phospholipids (hydrogenated soybean phospholipids), and soybean-derived phospholipids. Lysophospholipids derived from soybeans, hydrogenated lysophospholipids derived from soybeans, phospholipids derived from egg yolk, hydrogenated phospholipids derived from egg yolk, lysophospholipids derived from egg yolk and hydrogenated lysophospholipids derived from egg yolk, which One or more types of phospholipids can be used as needed, preferably: hydrogenated phospholipids derived from soybeans, hydrogenated lysophospholipids derived from soybeans, hydrogenated phospholipids derived from egg yolk, and hydrogenated lysophospholipids derived from egg yolk , more preferably: hydrogenated phospholipids derived from soybeans. These phospholipids can be used singly or in combination of two or more kinds as needed. In the present invention, the moisturizing effect of the phospholipid itself can be used in conjunction with ceramides and phytosterols to impart the moisturizing effect of the liposome composition of the present invention due to the moisture blocking property.

The content of component (A) in the liposome composition of the present invention is not particularly limited, preferably 0.5-20% by mass (hereinafter only marked as "%"), more preferably greater than 1% and less than 20%, more preferably 1% ~15%, and more preferably 3~10%. By setting it within this range, the stability of the liposome composition or the effect of inhibiting the crystallization of ceramides and phytosterols, and moreover, the water blocking property (moisture retention) or the sense of luster and firmness will be more excellent, so better. In addition, in this application, when containing several types of said component, component content means the total amount of these.

(Ingredient (B): Phytosterol) The component (B) phytosterol used in the present invention is a kind of sterols, and it will form a lipid bimolecular membrane together with the component (A). In addition, by combining component (B) phytosterols and component (C) ceramides contained in the liposome composition, moisture blocking property, luster, and firmness can be improved. The phytosterols are components contained in trace amounts in plants such as soybeans or rapeseeds, and are β-sitosterol, campesterol, stigmasterol, brassicasterol, etc. A mixture of several sterols. In the present invention, the component (B) is beneficial to the stability of the lipid bimolecular membrane structure, and the stability of the liposome can be improved by combining the component (B). In addition, since its molecular weight is higher than that of other sterols such as cholesterol and it is a mixture of multiple sterols, it can impart luster and firmness to the liposome composition of the present invention. Moreover, by combining with ceramides to make a liposome composition containing phytosterols, a blocking film can be formed on the skin and water evaporation can be inhibited, so excellent moisturizing effect brought by water blocking properties can be obtained . As a commercially available item of phytosterol, phytosterol QI (made by Eisai Food & Chemical Co., Ltd.) etc. are mentioned. In addition, in the present invention, it can also be used in the form of a mixture with the component (A) in advance. PHYTOPRESOME (Nippon Seika Co., Ltd.) etc. are mentioned as a commercial thing of phospholipid and phytosterol mixture. In addition, component (B) phytosterols do not include phytosterol derivatives such as polyoxyethylene phytosterols.

From the aspects of water blocking property, luster and firmness, the content of component (B) in the liposome composition of the present invention should be more than 0.05%, more preferably more than 0.1%, more preferably more than 0.1%, especially It should be more than 0.3%. The content of component (B) in the liposome composition of the present invention is not particularly limited, preferably 0.05-2%, more preferably 0.1-1.5%, more preferably 0.1-1%, and more preferably greater than 0.1% and 1% % or less, especially 0.2~1.0%. By setting it as this range, it becomes more excellent in the stability of a liposome composition, moisture-blocking property, glossiness, and firmness, and it is preferable.

In the present invention, the combination of component (A) and component (B) constituting the lipid bimolecular membrane of the liposome composition is important. In the present invention, the content mass ratio [(A)/(B)] of component (A) relative to component (B) is not particularly limited, preferably 1~30, more preferably 1~20, more preferably 2~10 , and more preferably 2 to 6, especially more than 2 and less than 6, particularly preferably 3 to 6. The content mass ratio [(A)/(B)] of component (A) to component (B) means the ratio of each component constituting the liposome skeleton. By setting it within this range, the stability of the liposome composition, the effect of inhibiting the crystallization of ceramides and phytosterols, and moreover, the water blocking property, luster, and firmness will be more excellent, which is preferable.

(Component (C): Ceramides) The component (C) ceramides used in the present invention are: linear and/or branched chain alkyl or alkenyl groups having more than one long chain in the molecule, at least two or more hydroxyl groups and one or more amide groups ( and/or amino) nonionic amphiphilic substances; or derivatives with lecithin residues or sugar residues bonded to the hydroxyl groups of the nonionic amphiphilic substances; and the ceramides It can be a natural extract or a synthetic one. Examples thereof include ceramide 1, ceramide 2, ceramide 3, and ceramide 4 of sphingosine, phytosphingosine, and long-chain fatty amide belonging to them. , ceramide 5, ceramide 6 and other natural ceramides; sphingomyelin (sphingomyelin), plant sphingomyelin and other sphingomyelin which are phospholipid derivatives of sphingosine and phytosphingosine (sphingophospholipid); glycosides such as cerebroside or ganglioside and other glycosphingolipids (sphingoglycolipids) and plant glycosphingolipids, etc., can use one of these Or use in combination of 2 or more types. Among them, natural ceramides are preferred, especially ceramide 2 and ceramide 3, from the viewpoint of moisturizing effect and stability of liposome composition. Commercially available natural ceramides include, for example, Ceramide I, Ceramide III, Ceramide VI (manufactured by EVONIC Co.), Ceramide TIC-001 (manufactured by Takasago Fragrance Co., Ltd.), and CERAMIDE 2 (manufactured by Croda Japan Co., Ltd.). , CERAMIDE3 (manufactured by COSMO FARM), Ceracare AC45 (manufactured by NFC Corporation), and the like.

The content of component (C) in the liposome composition of the present invention is not particularly limited, preferably 0.001-2%, more preferably 0.005-1%, more preferably 0.005-0.5%, and more preferably greater than 0.005% and 0.5% % or less, especially 0.01~0.5%. By setting it within this range, the stability of the liposome composition, the effect of inhibiting the crystallization of ceramides and phytosterols, and moreover, the water blocking property, luster, and firmness will be more excellent, which is preferable.

In the liposome composition containing ceramides of the present invention, the combination of components (A) to (C) is very important. The total amount of component (A) and component (B) relative to the mass ratio [{(A)+(B)}/(C)] of component (C) is not particularly limited, depending on the stability of the liposome composition, From the viewpoints of moisture sealing, luster, firmness, etc., it is preferably 5~1000, more preferably 10~700, and more preferably 30~500.

In the liposome composition of the present invention, the combination of component (B) and component (C) is important because it is related to moisture blocking property, luster, firmness, and the like. The mass ratio [(B)/(C)] of component (B) to component (C) in the liposome composition is not particularly limited, preferably 1-200, more preferably 1-100, more preferably greater than 1 and less than 100, more preferably 10 to 100. By setting it as this range, the liposome composition becomes more excellent in stability, moisture-blocking property, glossiness, and firmness, and it is preferable.

(Component (D): (d1) one or more polyols selected from IOB values of 1.8 to 3.5, and/or (d2) one or more polyols selected from IOB values of 4.5 to 5.5 or 2 or more) Component (D) used in the present invention is component (d1) a polyol having an IOB value of 1.8 to 3.5, and/or component (d2) a polyol having an IOB value of 4.5 to 5.5. Component (d1) a polyol having an IOB value of 1.8 to 3.5, and/or a component (d2) a polyol having an IOB value of 4.5 to 5.5 has a structure having two or more hydroxyl groups in the molecule. The IOB value of the present invention is a value calculated based on the organic concept map (Fujita Mu, Prediction of Organic Compounds and Organic Concept Map, Chemistry Field VOL.11, No.10(1957) 719-715). More specifically, in this organic concept diagram, the physical and chemical properties of compounds are defined as the degree of physical properties mainly caused by Van Der Waals force as "organicity", and the degree of physical properties mainly caused by the electric affinity The resulting degree of physicality is defined as the value expressed by "inorganicity". The IOB value is an index showing the balance between inorganic (inorganic) and organic (organic), and can be represented by IOB value=inorganic value/organic value. A compound having a larger value can be said to be a compound that exhibits a hydrophilic property, that is, a highly polar property. Among them, from the viewpoints of the stability of the liposome composition, the effect of inhibiting the crystallization of ceramides and phytosterols, etc., the IOB value of the component (d1) should be 1.8~3.3, more preferably 1.8~2.5. (d2) IOB value should be 4.5~5.0.

As the component (d1) of the above-mentioned IOB value, dipropylene glycol (IOB value=1.8), 1,3-butanediol (IOB value=2.5), diglycerin (IOB value=3.5), propylene glycol (IOB value= 3.3), etc., from the viewpoint of the stability of the liposome composition, the effect of inhibiting the crystallization of ceramides and phytosterols, etc., it is preferably one or two selected from dipropylene glycol, propylene glycol, and 1,3-butanediol. More than one, preferably one or two selected from dipropylene glycol and 1,3-butanediol, and more preferably 1,3-butanediol. In addition, glycerin (IOB value=5.0) and sorbitol (IOB value=5.0) can be mentioned as the component (d2). From the viewpoint of the stability of the liposome composition, the effect of inhibiting the crystallization of ceramides and phytosterols, etc. , preferably glycerin. These may be used individually or in combination of 2 or more types.

The content of component (D) in the liposome composition is not particularly limited, preferably 10-40%, more preferably 15-30%, more preferably 20-30%. By setting this range, the stability of the liposome composition and the effect of inhibiting the crystallization of ceramides and phytosterols will be more excellent, so it is preferable.

The content of the component (d1) in the liposome composition is not particularly limited, preferably 1-25%, more preferably 3-20%, more preferably 6-18%. By setting this range, the stability of the liposome composition and the effect of inhibiting the crystallization of ceramides and phytosterols will be more excellent, so it is preferable.

Also, the content of the component (d2) in the liposome composition is not particularly limited, but is preferably in the range of 5-20%, more preferably in the range of 8-15%, and more preferably in the range of 8-12%. By setting this range, the stability of the liposome composition and the effect of inhibiting the crystallization of ceramides and phytosterols will be more excellent, so it is preferable.

In terms of the stability of the liposome composition over time in a wide temperature range, a preferred aspect is that the component (d1) is selected from the group consisting of dipropylene glycol, propylene glycol, and 1,3-butanediol At least one of them, and component (d2) is glycerin.

In the present invention, the component (D) preferably contains at least the component (d1), and it is preferable to use the components (d1) and (d2) together. In the present invention, from the viewpoint of the stability of the liposome composition, the effect of inhibiting the crystallization of ceramides and phytosterols, etc., the content mass ratio of component (d1) relative to component (d2) )] should be 0.2~2, more preferably 0.6~1.8, more preferably 1~1.6.

In addition, in the present invention, component (D) preferably contains at least 1,3-butanediol in order to form a stable liposome composition with good solubility of ceramides and phytosterols, which can inhibit crystallization. From the viewpoint of the stability of the liposome composition, the effect of inhibiting the crystallization of ceramides and phytosterols, etc., the mass ratio of 1,3-butanediol contained in component (D) [(1,3-butanediol Alcohol)/(D)] should be 0.1~1, more preferably 0.2~0.8, more preferably 0.4~0.7.

In addition, polyhydric alcohols with a low IOB value have excellent affinity with phytosterols, so there is a possibility of destabilizing the liposome composition due to elution of phytosterols. Therefore, in the liposome composition of the present invention, the polarity balance of component (D) {according to the weighted average of the IOB values shown in component (D) according to the content mass ratio (hereinafter only marked as "component (D) The weighted average of the IOB value (hereinafter only marked as "the weighted average of the IOB value of the component (D)")} is very important. In the present invention, the calculation of the weighted average of the IOB value of the component (D) is determined as The value obtained by dividing the sum of the products of the respective polyol contents (g) and the respective IOB values of the components (d1) and (d2) corresponding to the component (D) by the sum (g) of the polyol contents (the following formula ( 1) Values shown). The weighted average of the IOB value of component (D) = [(D1: content × IOB value) + (D2: content × IOB value) + (D3: content × IOB value) + ... / (D1 + D2 + D3 + ...: content )]…(Formula 1)

In the present invention, the weighted average of the IOB values of the component (D) is greater than 2.0 in terms of the lower limit. If the weighted average of the IOB value of component (D) is 2.0 or less, the elution of phytosterols will occur over time, and as a result, there may be concerns about the precipitation of ceramides and phytosterols, and the disintegration of the liposome composition. Moreover, the weighted average of the IOB value of a component (D) is less than 5.0 as an upper limit. If the weighted average of the IOB value of the component (D) is 5.0 or more, the phytosterol cannot be dissolved, the liposome composition cannot be formed sufficiently, and the stability of the liposome composition tends to decrease. And not getting enough firmness. The weighted average of the IOB value of component (D) is preferably 2.3 or more, more preferably 2.5 or more, more preferably 3.0 or more, more preferably more than 3.2, especially more than 3.3. In addition, it is preferably 4.6 or less, more preferably 4.0 or less. By setting it within this range, the stability of the liposome composition, the effect of inhibiting the crystallization of ceramides and phytosterols, and the water blocking property will be more excellent, so it is preferable.

Also, in the liposome composition of the present invention, it is important to consider the solubility of component (B) to component (D). In the present invention, the mass ratio [(D)/(B)] of component (D) to component (B) is not particularly limited, but is preferably 10 or more, more preferably 15 or more, and more preferably 20 or more. When the content mass ratio [(D)/(B)] of the component (D) to the component (B) is equal to or greater than the above lower limit, the stability over time (the effect of inhibiting the crystallization of ceramides and phytosterols or Stability of liposome composition). The content mass ratio [(D)/(B)] of component (D) to component (B) is preferably 300 or less, 250 or less, 100 or less, 60 or less, and 50 or less in this order. By setting it as this range, since moisture blocking property, luster, and firm feeling will be more excellent, it is preferable. The content mass ratio [(D)/(B)] of component (D) relative to component (B) is preferably 10~250, more preferably 10~100, more preferably 10~60, and more preferably 15~60 , especially preferably 15~50. Moreover, the combination with component (d1) which is excellent in solubility with component (B) can also be set suitably from a viewpoint, such as the stability of a liposome composition. In the present invention, the content mass ratio [(d1)/(B)] of component (d1) relative to component (B) is not particularly limited, preferably 5~150, more preferably 10~100, more preferably 10~50 , and more preferably 10~40. By setting it as this range, since the stability of a liposome composition etc. will become more excellent, it is preferable.

In the liposome composition of the present invention, the content mass ratio [(D)/{(A)+(B)}] of component (D) relative to the total amount of component (A) and component (B) is not particularly limited, preferably It is in the range of 1 to 20, more preferably in the range of 3 to 17, more preferably in the range of 3 to 10. By setting it within this range, the stability of the liposome composition, the effect of inhibiting the crystallization of ceramides and phytosterols, the moisture blocking property, the sense of luster and the sense of firmness will be more excellent, so it is preferable.

In the liposome composition of the present invention, the ratio of constituent components (A) to (D) can be appropriately set. In the liposome composition of the present invention, the total amount of component (A), component (B) and component (C) is contained in a mass ratio with respect to component (D) [{(A)+(B)+(C)}/ (D)] is not particularly limited, preferably 0.05~1, more preferably 0.1~0.7, more preferably 0.1~0.5. By setting it within this range, the stability of the liposome composition, the effect of inhibiting the crystallization of ceramides and phytosterols, and moreover, the water blocking property, luster, and firmness will be more excellent, which is preferable.

The dispersion medium of the liposome composition of the present invention is an aqueous solvent. Aqueous solvents contain water as the main component. Here, the so-called main component refers to water containing more than 50% (upper limit: 100%), preferably more than 60%, more preferably more than 70%, more preferably more than 80%. The water is not particularly limited. For example, other than purified water, hard water, soft water, natural water, tap water, sea water, deep ocean water, electrolyzed alkaline ionized water, electrolyzed acidic ionized water, ionized water, and cluster water can be used. The water content is not particularly limited, and may be contained appropriately depending on the amount of other components. Other aqueous solvents that can be mixed with water can be used as the aqueous solvent, and lower alcohols such as ethanol and 2-propanol can be used as the other aqueous solvents, and these can be used alone or in combination of two or more. The liposome composition of the present invention contains component (D) (part of it) in an aqueous solvent.

In the present invention, the content of component (D) in the aqueous solvent and component (D) is not particularly limited, preferably 10-60%, more preferably 20-60%, more preferably 20-50%. By setting it within this range, the stability of the liposome composition, the effect of inhibiting the crystallization of ceramides and phytosterols, and the water blocking property will be more excellent, so it is preferable. The total content of the aqueous solvent and component (D) in the liposome composition of the present invention is not particularly limited, preferably 40-99%, more preferably 50-98%.

Also, the water content in the liposome composition should be 20-80%, more preferably 30-75%, the water content in the aqueous solvent should be 40-90%, more preferably 40-80%, more preferably 50~80%. Moreover, from the viewpoint of the stability of the liposome composition, the effect of inhibiting the crystallization of ceramides and phytosterols, and the water blocking property, the content mass ratio of the component (D) and water in the liposome composition [component (D) )/water] should be 0.2~2, more preferably 0.2~1.5, more preferably 0.2~1.

(Component (E): one or more selected from organic acids, inorganic acids, and salts thereof) The liposome composition of the present invention can further use one or more kinds of component (E) selected from organic acids, inorganic acids, and salts thereof. By using component (E), crystals of ceramides and phytosterols will not be precipitated and phytosterols will not be eluted, especially during long-term storage at high temperature, and it will be more stable over time.

Component (E) used in the present invention is not particularly limited, and examples of organic acids include citric acid, lactic acid, formic acid, acetic acid, oxalic acid, malic acid, tartaric acid, succinic acid, glycolic acid, aspartic acid, glutamic acid, Examples of the polyglutamic acid include phosphoric acid, hydrochloric acid, sulfuric acid, boric acid, and the like as inorganic acids. Examples of salts of organic acids or inorganic acids include alkali metal salts such as sodium salts and potassium salts of the aforementioned acids, alkanolamine salts such as triethanolamine salts, and the like. Among these, from the viewpoint of the stability of the liposome composition or the effect of inhibiting the crystallization of ceramides and phytosterols, it is more preferable to be one selected from the salts of phosphoric acid, citric acid, succinic acid, and the like. From the viewpoint of the stability of the liposome composition, one or more kinds selected from succinic acid and its salts are more preferable. Specifically, succinic acid and/or sodium succinate are preferred, and it is particularly preferred to use succinic acid and sodium succinate in combination. In addition, component (E) does not contain aromatic compounds, such as benzoic acid.

The content of component (E) in the liposome composition of the present invention is not particularly limited, preferably 0.0001-1%, more preferably 0.001-1%, more preferably 0.001-0.6%. By setting this range, the stability of the liposome composition and the effect of inhibiting the crystallization of ceramides and phytosterols will be more excellent, so it is preferable. Also, the mass ratio [(E)/(C)] of component (E) to component (C) is not particularly limited, but is preferably 0.1-15, more preferably 0.1-12, more preferably 0.2-5. By setting this range, the stability of the liposome composition and the effect of inhibiting the crystallization of ceramides and phytosterols will be more excellent, so it is preferable.

(Ingredient (F): Hydrolyzed Yeast Protein) By further using the component (F) hydrolyzed yeast protein in the liposome composition of the present invention, a liposome composition excellent in water blocking property and/or stability can be prepared. In the present invention, the so-called hydrolyzed yeast protein refers to the following: those obtained by autodigestion or acid hydrolysis of yeast belonging to Saccharomyces cerevisiae, Candida, etc.; It is obtained by extracting dry powder of yeast, or a water-soluble extract obtained by putting yeast in a culture medium and irradiating it with ultraviolet rays. Any of the above-mentioned ones in the present invention can be used as the hydrolyzed yeast protein, but it is preferably obtained from the yeast belonging to Candida. As a commercial item, CHRONOGEN YST (manufactured by ASHLAND) etc. are mentioned.

The content of component (F) in the liposome composition of the present invention is not particularly limited, and from the viewpoints of the stability of the liposome composition, the effect of inhibiting the crystallization of ceramides and phytosterols, and/or the water blocking property, it is preferably 0.0001~1%, more preferably 0.0005~0.5%, more preferably 0.0005~0.1%. By setting it as this range, since the stability of a liposome composition can be maintained over time and a moisturizing effect can be given further, it is preferable.

In the present invention, the above-mentioned component (E) and/or component (F) can be contained in the liposome composition, and can also be added in addition to the composition to prepare cosmetics or external skin preparations. However, due to the effects of the present invention (especially From the viewpoint of stability over time), component (E) and/or component (F) is preferably added separately from the liposome composition to prepare cosmetics or external skin preparations.

In view of the stability of liposomes, etc., the pH of the liposome composition of the present invention is preferably set at 5-8. By setting it as this range, the stability of a liposome composition is excellent, and the liposome composition excellent in moisture blocking property, luster, and firm feeling can be obtained. In addition, in the present application, the pH measurement is performed at 20° C., and the measurement uses a glass electrode type hydrogen ion concentration meter (manufactured by Horiba, Ltd.).

To manufacture the liposome composition of the present invention, conventional methods known to those skilled in the art can be used. It is not particularly limited, for example, the components (A)~(D) can be heated in advance and mixed uniformly, and then the heated water-based component can be added thereto while stirring. In addition to the above-mentioned aqueous solvent, the aqueous component optionally contains other aqueous components. Component (E) and component (F) are this aqueous component. Here, the obtained agent was observed with a polarizing microscope, and the presence of a Maltese cross image was observed under crossed polarized light, thereby confirming the formation of a lipid bimolecular film. Next, this is subjected to high-pressure treatment using, for example, a high-pressure homogenizer.

The average particle size of the liposome composition of the present invention is not particularly limited, and from the viewpoint of better exerting the effect of the present invention, it is preferably 50-300 nm, more preferably 100-250 nm, and more preferably 100-200 nm. The average particle diameter of the liposome composition of the present invention is the value measured by using the examples.

The liposome composition of the present invention may contain additives of arbitrary components within the range not to interfere with the effects of the present invention and the formation of the liposome composition. Specific examples of the optional components include oils, alcohols, powders, water-soluble polymers, film-forming agents, surfactants other than component (A), oil-soluble gelling agents, and organically modified clay minerals. , resins, ultraviolet absorbers, preservatives, antibacterial agents, fragrances, antioxidants, pH adjusters other than component (E), chelating agents, active ingredients for skin, etc.

In particular, for the purpose of improving the stability of the liposome composition, stabilizing aids such as surfactants, higher alcohols, and higher fatty acids are used in the liposome composition. These ingredients can also be used in the liposome composition of the present invention, but there are doubts about the safety of the skin, the reduction of moisture blocking ability, and the reduction of usability such as the sticky feeling caused by the stabilizing agent. Therefore, in the liposome composition of the present invention, the content of the stabilizing aid is preferably less than 1%, more preferably less than 0.5%, more preferably 0% (not contained). Here, the so-called stabilizing aids include the following: anionic surfactants, cationic surfactants, nonionic surfactants, amphoteric surfactants other than component (A) and other surfactants; Higher alcohols such as stearyl alcohol and behenyl alcohol; higher fatty acids such as palmitic acid and stearic acid, etc. Wherein, when the present invention contains a stabilizing aid, the stabilizing aid is preferably a nonionic surfactant, more preferably a nonionic surfactant having a polyoxyalkylene group, from the viewpoint of the stability of the liposome composition or the moisture blocking property, etc. Sexual surfactant.

In addition, in the composition containing ceramides, in order to suppress the crystallization of ceramides, an oil agent or the like which can dissolve ceramides may be used. Although oils can also be used in the liposome composition of the present invention, the phytosterols that can form closed cells will dissolve (dissolve) into the oil, and the stability of the liposome composition will decrease, crystallization, Or doubts such as decreased gloss or firmness due to stickiness, etc., so the oil content should be less than 1%, more preferably less than 0.5%, and more preferably 0% (not included). Here, the oil agent is not particularly limited as long as it is generally used in cosmetics, quasi-drugs, drugs, and the like. Specifically, the following can be mentioned: olive oil, castor oil, mink oil, macadamia nut oil, avocado oil, meadowfoam oil and other vegetable oils; jojoba oil , Diisobutyl adipate, 2-hexyldecyl adipate, di-2-heptyl undecyl adipate, alkyl glycol monoisostearate, isocetyl isostearate , trimethylolpropane triisostearate, ethylene glycol di-2-ethylhexanoate, neopentyl glycol di-2-ethylhexanoate, trimethylol tri-2-ethylhexanoate Propanyl esters, neopentylthritol tetrakis-2-ethylhexanoate, cetyl 2-ethylhexanoate, oleyl oleate, octyldodecyl oleate, decyl oleate, neopentyl dicaprate Alcohol Esters, Triethyl Citrate, 2-Ethylhexyl Succinate, Isocetyl Stearate, Butyl Stearate, Diisopropyl Sebacate, Di-2-Ethylhexyl Sebacate Esters, Cetyl Lactate, Myristyl Lactate, Isopropyl Palmitate, 2-Ethylhexyl Palmitate, 2-Hexyldecyl Palmitate, 2-Heptyl Undecyl Palmitate, Dineopentaerythritol Fatty acid ester, isononyl isononanoate, isotridecyl isononanoate, isopropyl myristate, isopropyl palmitate, 2-octyldodecyl myristate, 2-hexyldecyl myristate Esters, myristyl myristate, hexyldecyl dimethyl octanoate, ethyl laurate, hexyl laurate, 2-ethylhexyl methoxycinnamate, diisostearyl malate, tri-2-ethyl Glyceryl caproate, Glyceryl tri(caprylic acid and capric acid), Glyceryl tricaprate, Glyceryl triisostearate, Diglyceryl diisostearate, Diglyceryl triisostearate, Tetraisostearate Diglyceryl Stearate, Decacyl Isostearate, Glyceryl Triisopalmitate, Glyceryl Trimyristate, Diglyceryl Isostearate Myristate, Tridecyl Trimellitate (tritridecyl trimellitate), N-lauroyl-L-glutamic acid-2-octyl dodecyl ester, N-lauroyl-L-glutamic acid bis(vegetable stearyl. 2-octyl dodecyl ) esters and other ester oils; low polymerization degree dimethyl polysiloxane, high polymerization degree dimethyl polysiloxane, methylphenyl polysiloxane, decamethylcyclopentasiloxane, octamethyl Silicone oils such as cyclotetrasiloxane and fluorine-modified organopolysiloxane; fluorinated oils such as perfluorodecane, perfluorooctane, and perfluoropolyether; isododecane and isohexadecane Alkanes, light liquid isoparaffins, liquid paraffin, heavy liquid isoparaffins, α-olefin oligomers, squalane, polyisobutylene, polybutene and other hydrocarbons; lanolin acetate, lanolin fatty acid isopropyl ester, Lanolin alcohol derivatives such as lanolin alcohol; higher alcohols such as isostearyl alcohol and octyldodecanol; higher fatty acids such as isostearic acid and oleic acid; dextrin fatty acid esters, sucrose fatty acid esters, starch Fatty acid esters, 12-hydroxystearic acid (12-hydroxystearic acid), aluminum stearate, inulin stearate, calcium stearate and other oily gelling agents; ethyl p-aminobenzoate, p-formaldehyde Oxycinnamic acid-2-ethylhexyl, 4-tertiary butyl-4'-methoxydibenzoylmethane, 2-hydroxy-4-methoxybenzophenone (Oxybenzone) and other oil-soluble UV rays Absorbents.

The liposome composition of the present invention obtained in the above manner can be directly used as cosmetics or external skin preparations, or can be further combined with other ingredients to make cosmetics or external skin preparations. Examples include skin care cosmetics such as lotion, lotion, cream, eye cream, beauty essence, massage material, mask material, hand cream, body lotion, body cream, cosmetic base cosmetics for makeup, and external liquids , External gels, creams, ointments, liniments, lotions, poultices, plasters, sprays, aerosols and other skin external agents. The content of the liposome composition in cosmetics or external skin preparations is not particularly limited. For example, in cosmetics or external skin preparations, it is preferably 20-80%, more preferably 30-70%, and more preferably 40-60%. Also, the dosage form is not particularly limited, and various dosage forms such as water-based cosmetics and oil-in-water cosmetics can be used. In addition, in this specification, quasi-drugs and drugs are included in external skin preparations.

A water-based cosmetic is mentioned as a preferred dosage form of the cosmetic or skin external preparation of the present invention. In this specification, the term "aqueous cosmetic" refers to a dosage form in which a water phase composed of an aqueous solvent is used as a continuous phase and does not substantially contain an oil agent. In this specification, the term "substantially free of oils" means that the content of oils other than component (B) and (C) in the cosmetic is less than 0.5%, preferably less than 0.1%, more preferably less than 0.05%. Here, as the oil agent, those listed above can be mentioned.

In view of the stability of the liposome composition, the effect of inhibiting the crystallization of ceramides and phytosterols, etc., cosmetics should contain one or more selected from the following: Component (E') is selected from organic acids Or one or two or more of inorganic acids and their salts (except for aromatic compounds as organic acids or inorganic acids), and component (F') hydrolyzed yeast protein. In this specification, in order to distinguish it from the component (E) and component (F) contained in the liposome composition, it is selected from organic acids, inorganic acids, and salts thereof added to cosmetics or external skin preparations. One or more of them are components (E'), and hydrolyzed yeast proteins are components (F').

The content of component (E') in cosmetics or external skin preparations is not particularly limited. From the viewpoint of the stability of the liposome composition or the effect of inhibiting the crystallization of ceramides and phytosterols, etc., it can be used in cosmetics or external skin preparations. The dosage is preferably 0.0001-1%, more preferably 0.001-1%, more preferably 0.001-0.6%, more preferably more than 0.001% and less than 0.6%, especially preferably 0.05-0.5%. In addition, the mass ratio [(E')/(C)] of component (E') to component (C) in cosmetics or skin external preparations is not particularly limited. From the viewpoint of the crystallization effect of amides and phytosterols, it is preferably 0.1-15, more preferably 0.1-12, more preferably 0.2-5. Other specific aspects of component (E') are the same as component (E) described in the liposome composition.

The content of component (F') in cosmetics or skin external preparations is not particularly limited. From the viewpoint of the stability of liposome composition, the effect of inhibiting the crystallization of ceramides and phytosterols, and the moisture blocking property, it is used in cosmetics. It is preferably 0.0001-1%, more preferably 0.0005-0.5%, more preferably 0.0005-0.1%, more preferably 0.0005% to less than 0.1%, and especially preferably 0.0005-0.08% in ingredients or external skin preparations. Other specific aspects of the component (F') are the same as the component (F) described above for the liposome composition.

Components that are usually blended in cosmetics or external skin preparations may be blended in cosmetics or external skin preparations. Described composition can enumerate following all etc.: oil agent, surfactant (anionic surfactant, nonionic surfactant, amphoteric surfactant, cationic surfactant), thickener (gelling agent, macromolecule surfactant) ), colorants, powders other than colorants, lower alcohols such as ethanol, polyols, ultraviolet absorbers, pH adjusters, antioxidants, metal chelating agents, preservatives, fragrances, and various chemicals. In addition, in cosmetics or external skin preparations, in addition to components (A) to (F) and water-based components used when forming liposome compositions, polyhydric alcohols or water of the same components may be included, but they are related to lipids. The ingredients (A)~(F) used in the body composition are distinguished. That is, when a polyhydric alcohol such as 1,3-butanediol is added to the liposome composition in cosmetics or external skin preparations, the polyhydric alcohol such as 1,3-butanediol is distinguished from the component (D) Open, not included in the content of component (D), etc. Example

Hereinafter, the present invention will be further specifically described using examples and the like, but the present invention is not limited to the following examples and the like.

Liposome composition: embodiment 1-1~1-14, comparison 1-1~1-4 The liposome composition was prepared according to the following prescription and method. For each liposome composition obtained, the "average particle size", "moisture blocking property", "temporal stability (5°C and -10⇔20°C/1 month)", "gloss" were evaluated according to the following methods and criteria sense", "tightness". And the results are listed in Tables 1 and 2.

[Table 1] Mass%

[Table 2] Mass%

＜Manufacturing method＞ A: Heat ingredients (1)~(9) to 80°C and mix uniformly. B: Component (10) was heated to 80°C. C: Slowly add B to A and disperse with a disperser. D: After cooling C to room temperature, it was prepared by high-pressure treatment with a fine fluid homogenizer.

＜Evaluation＞ 1. Average particle size Each sample was filled into a plastic optical cuvette UVette 220-1600 nm (manufactured by Eppendorf), and the average particle size was measured with an instant nanometer particle size measuring device DelsaMax CORE (manufactured by Beckman Coulter Co., Ltd.).

2. Moisture blocking The moisture blocking property of the present invention is evaluated by the following method in an environment with a relative humidity of 30RH%, and is judged according to the following 3-stage judgment criteria. A: Put 10 g of water into a vial (Vials With Rubber Stopper/V-20, capacity: 20 mL). B: Seal the opening of the aforementioned vial with filter paper (glass microfiber filter paper (GLASS MICROFIBER FILTERS), diameter: 21 mm), apply 80 µL of each sample concentrated to 2 times on the upper part of the filter paper, and measure the weight (initial weight ). C: After standing for 48 hours, the weight of the vial (weight after standing) was measured. D: Calculate the water evaporation rate (%) {[(initial weight-weight after placement)/(initial weight)]×100}.

3 stages of judgment criteria; [judgment]: [judgment criteria] ◎(Excellent): Evapotranspiration rate below 1.8% ○ (good): Evaporation rate greater than 1.8% and less than 2.4% × (poor): water evapotranspiration rate greater than 2.4%

3. Stability over time (the effect of inhibiting the crystallization of ceramides and phytosterols) For the liposome composition stored at a constant temperature of 5°C and -10⇔20°C (24-hour cycle) for 1 month, use an upright microscope (manufactured by Olympus) at a magnification of 400 times and an exposure time of 1/200 second Observe under polarized light. If ceramides and phytosterols exist in the composition in the form of crystals, they will be observed as white bright objects under polarized light. In addition, even if no crystalline bright substance is formed, when the crystallization progresses, it will be observed as a gray tone image under a microscope as unclear bright substances of ceramides and phytosterols. Regarding the effect of inhibiting the crystallization of ceramides and phytosterols, it is observed whether there are crystals derived from ceramides and phytosterols, and judged according to the following 3-stage judgment criteria.

3 stages of judgment criteria; [judgment]: [judgment criteria] ◎(Excellent): No crystalline bright substances derived from ceramides and phytosterols were confirmed ○ (good): Unclear ceramides and/or phytosterol-derived crystalline brighteners can be identified × (inferior): Bright crystals derived from ceramides and phytosterols can be confirmed

4. Stability over time (stability of liposome composition) Measure the average particle size of each sample after being stored at a constant temperature of 5°C and -10⇔20°C for one month by the above evaluation method, and evaluate the liposome composition based on the change rate of the average particle size after manufacturing The maintenance of formation, and the stability of the liposome composition was judged according to the following 4-stage judging criteria.

4 stages of judgment criteria; [judgment]: [judgment criteria] ◎(Excellent): The change rate of average particle size is less than ±20% ○ (good): The change rate of the average particle size is more than ±20% and less than ±40% △ (slightly worse): The change rate of the average particle size is more than ±40% and less than ±60% × (Bad): The change rate of the average particle size is ±60% or more

5. Gloss and firmness 10 people from the 35-50-year-old cosmetics special evaluation and investigation team asked the 10 people to use each of the products 1-1~1-14 of the present invention and the comparison products 1-1~1-4 after washing their faces twice a day in the morning and evening. Take the sample in your hands to the size of a grain of rice, and apply it to your entire face. Carry out the above for 2 weeks, and for each sample, perform a sensory evaluation of gloss and firmness in 5 stages according to the following (1) evaluation criteria, and further evaluate the average value of each sample according to the 4 stages of (2) below Judgment criteria are used for judgment.

(1) Assessment criteria; [Evaluation Result]: [Score] Very good: 5 points Good: 4 points Normal: 3 points Slightly worse: 2 points Poor: 1 point (2) Judgment criteria; [Judgement]: [Average Score] ◎(excellent): 4.5 or above ○ (good): Above 3.5 ~ less than 4.5 △ (slightly worse): more than 1.5 to less than 3.5 × (poor): less than 1.5.

It is evident from the aforementioned Tables 1 and 2 that among the liposome compositions of Examples 1-1 to 1-14, the stability of the liposome compositions is excellent, and the effect of inhibiting the crystallization of ceramides and phytosterols is excellent. Furthermore, it can be seen that effects such as moisture blocking property, luster, and firmness are also excellent.

On the other hand, as shown in the aforementioned Table 2, in Comparative Example 1-1 that does not contain phytosterols, it is not possible to obtain the moisture blocking property, the stability of the liposome composition over time, the luster, and the sense of firmness. Satisfied. In Comparative Example 1-2 in which cholesterol was used instead of phytosterols, the liposome composition was excellent in stability and the like, but the luster and firmness were insufficient. Also, in Comparative Example 3 in which the weighted average of the IOB value of component (D) was 2.0, crystals derived from ceramides and phytosterols were observed, and destabilization of the liposome composition was confirmed. In Comparative Example 4 in which the weighted average of the IOB value of component (D) was 5.0, no liposome composition was satisfactory in terms of stability and firmness. In addition, the liposome compositions obtained in the examples are all pH 5-8.

Preparation of water-based cosmetics: Examples 2-1~2-9 Water-based cosmetics containing liposome composition were prepared according to the following prescription and production method, and the "temporal stability (50°C/1 month)" was evaluated according to the same method and criteria as above. The results are listed in Table 3.

[Table 3] Mass%

＜Manufacturing method＞ A: Heat ingredients (1)~(6) to 80°C and mix them uniformly. B: Component (7) was heated to 80°C. C: Slowly add B to A and disperse with a disperser. D: After cooling C to room temperature, a liposome composition was obtained by performing high-pressure treatment with a microfluidic homogenizer. E: Components (8) to (15) are uniformly mixed. F: Add and mix D to E to prepare a cosmetic.

＜Evaluation＞ 5. Stability over time (the effect of inhibiting the crystallization of ceramides and phytosterols) For each sample stored at a constant temperature of 50°C for one month, the evaluation was carried out according to the above-mentioned method and standard. 6. Stability over time (stability of liposome composition) For each sample stored at a constant temperature of 50°C for one month, the evaluation was carried out according to the above-mentioned method and standard.

It is evident from Table 3 that the water-based cosmetics of Examples 2-1 to 2-9 are all excellent in the stability of the liposome composition even at high temperatures, and are excellent in the effect of inhibiting the crystallization of ceramides and phytosterols . In addition, Examples 2-1 to 2-9 are also excellent in stability over time under low temperature or temperature cycle, moisture blocking property, luster, firmness and other effects. In addition, the obtained liposome compositions are all pH 5-8.

<Example 2-10 White turbid lotion containing liposome composition> (prescription) [mass%] (1) Hydrogenated soybean phospholipids (ingredient (A)) 5.5 (2) Phytosterol Note 1 (Component (B)) 1.0 (3) Ceramide 2 Note 2 (Component (C)) 0.02 (4) Glycerin (ingredient (D)) 10 (5) 1,3-Butanediol (component (D)) 15 (6) Succinic acid (ingredient (E)) 0.0007 (7) Disodium succinate (ingredient (E)) 0.0033 (8) Hydrolyzed Yeast Protein Note 4 (Ingredient (F)) 0.001 (9) Water remaining (68.475) (liposome composition 50%) (10) Hydrolyzed Hyaluronic Acid 1.0 (11) Tocopherol 0.05 (12) (Acrylates/acrylic acid (C10-30)) cross-linked polymer 0.4 (13) Dipropylene glycol 3.0 (14) Sodium hydroxide 0.15 (15) Phenoxyethanol 0.5 (16) Sodium benzoate 0.001 (17) Water remaining (44.899) (Liposome composition: 100% based on ingredients (1)~(9); lotion: 50% of liposome composition of ingredients (1)~(9) and 50% of additives after ingredients (10)~(17) , totaling 100%; the following examples are all the same) (preparation method) A: Heat components (1)~(3) and (5) to 80°C and mix them uniformly. B: Add ingredient (4) heated to 80°C to A and mix uniformly. C: Slowly add ingredients (6)~(9) heated to 80°C into B, and disperse with a disperser. D: Cool C to room temperature and perform high-pressure treatment with a fine fluid homogenizer to obtain a liposome composition. The stability of the liposome composition at 50°C 1M (inhibition of crystallization of ceramides and phytosterols and formation maintenance of the liposome composition) was ◎ under the above evaluation criteria. E: D and components (10) to (17) are mixed to obtain a cloudy lotion.

The liposome composition of the obtained cloudy lotion was excellent in stability, and crystallization of ceramides and phytosterols was not confirmed. In addition, it is also excellent in effects such as moisture blocking property, luster, firmness, and the like. In addition, the weighted average of the IOB values of the contained component (D) was 3.5. Also, [(A)/(B)]=5.5, [(D)/(B)]=25, and [(D)/{(A)+(B)}]=3.8.

<Example 2-11 White turbid lotion containing liposome composition> (prescription) [mass%] (1) Hydrogenated soybean phospholipids (ingredient (A)) 8.0 (2) Phytosterol Note 1 (Component (B)) 2.0 (3) Ceramide 2 Note 2 (Component (C)) 0.02 (4) Glycerin (ingredient (D)) 11 (5) 1,3-Butanediol (component (D)) 10 (6) Dipropylene glycol (ingredient (D)) 4.0 (7) Succinic acid (ingredient (E)) 0.01 (8) Disodium succinate (ingredient (E)) 0.05 (9) Hydrolyzed Yeast Protein Note 4 (Ingredient (F)) 0.01 (10) Water remaining (liposome composition 60%) (11) Xanthan gum 0.1 (12) Tocopherol 0.05 (13)Carbomer 0.4 (14) Hydroxyethyl cellulose 0.2 (15) Sodium hydroxide 0.15 (16) Phenoxyethanol 0.5 (17) Ethanol 1.0 (18) Sodium benzoate 0.001 (19) Water remaining (preparation method) A: Heat ingredients (1)~(6) to 80°C and mix them uniformly. B: Components (7) to (10) were heated to 80°C. C: Slowly add B to A and disperse with a disperser. D: Cool C to room temperature and perform high-pressure treatment with a fine fluid homogenizer to obtain a liposome composition. E: D and components (11) to (19) were mixed to obtain a cloudy lotion.

The liposome composition of the obtained cloudy lotion was excellent in stability, and crystallization of ceramides and phytosterols was not confirmed. In addition, it is also excellent in effects such as moisture blocking property, luster, firmness, and the like. In addition, the weighted average of the IOB values of the contained component (D) was 3.5. Also, [(A)/(B)]=4, [(D)/(B)]=12.5, and [(D)/{(A)+(B)}]=2.5.

<Example 2-12 Beauty essence containing liposome composition> (prescription) [mass%] (1) Hydrogenated soybean phospholipids (ingredient (A)) 3.0 (2) Phytosterol Note 1 (Component (B)) 0.5 (3) Ceramide 2 Note 2 (Component (C)) 0.05 (4) Glycerin (ingredient (D)) 10 (5) 1,3-Butanediol (component (D)) 15 (6) Remaining amount of water (liposome composition 50%) (7) Xanthan gum 0.3 (8) Carbomer 0.3 (9) Hydroxyproline 0.1 (10) Tocopherol 0.02 (11) Succinic acid (ingredient (E')) 0.01 (12) Disodium succinate (ingredient (E')) 0.05 (13) Hydrolyzed Yeast Protein Note 4 (Ingredient (F')) 0.05 (14) Sodium benzoate 0.001 (15) Sodium hydroxide 0.1 (16) Water remaining (preparation method) A: Heat components (1)~(3) and (5) to 80°C and mix them uniformly. B: Add ingredient (4) heated to 80°C to A and mix uniformly. C: Slowly add component (6) heated to 80°C to B, and disperse with a disperser. D: Cool C to room temperature and perform high-pressure treatment with a fine fluid homogenizer to obtain a liposome composition. E: Components (7) to (16) are uniformly mixed. F: Add D to E and mix uniformly to obtain a beauty serum.

The liposome composition of the obtained beauty essence was excellent in stability, and crystallization of ceramides and phytosterols was not confirmed. In addition, it is also excellent in effects such as moisture blocking property, luster, firmness, and the like. In addition, the weighted average of the IOB values of the contained component (D) was 3.5. Also, [(A)/(B)]=6, [(D)/(B)]=50, and [(D)/{(A)+(B)}]=7.1.

<Example 2-13 Oil-in-water emulsion containing liposome composition> (prescription) [mass%] (1) Hydrogenated soybean phospholipids (ingredient (A)) 3.0 (2) Phytosterol Note 1 (Component (B)) 0.5 (3) Ceramide 2 Note 2 (Component (C)) 0.05 (4) Glycerin (ingredient (D)) 10 (5) 1,3-Butanediol (component (D)) 15 (6) Dipropylene glycol (ingredient (D)) 5.0 (7) Water remaining (liposome composition 50%) (8) Hydrogenated polydecene Note 5 0.5 (9) Macadamia nut fatty acid phytosterol ester Note 6 0.5 (10) Tocopherol 0.01 (11) Cetyl 2-ethylhexanoate 1.0 (12) polyoxyethylene hardened (60) castor oil 0.8 (13) Cetearyl Alcohol 0.15 (14) (Acrylates/acrylic acid (C10-30) crosslinked polymer 0.2 (15)Carbomer 0.3 (16) Xanthan gum 0.1 (17) Sodium hydroxide 0.15 (18) Succinic acid (ingredient (E')) 0.01 (19) Disodium succinate (ingredient (E')) 0.05 (20) Hydrolyzed Yeast Protein Note 4 (Ingredient (F')) 0.5 (21) Sodium benzoate 0.015 (22)Spice 0.1 (23) Ethanol 2.0 (24) Disodium ethylenediaminetetraacetic acid (EDTA-2Na) 0.05 (25) Phenoxyethanol 0.5 (26) Water remaining Note 5: SILKFLO 364 (manufactured by LIPO CHEMICALS INC) Note 6: PLANDOOL-MAS (manufactured by Nippon Seika Co., Ltd.) (preparation method) A: Heat ingredients (1)~(6) to 80°C and mix them uniformly. B: Component (7) was heated to 80°C. C: Slowly add B to A and disperse with a disperser. D: Cool C to room temperature and perform high-pressure treatment with a fine fluid homogenizer to obtain a liposome composition. E: Ingredients (8)~(13) were heated to 70°C and mixed uniformly. F: A part of ingredients (24), (25) and (26) was heated to 70° C. and uniformly mixed. G: Add F to E, stir and emulsify with a disperser. H: After cooling G to room temperature, D, components (14) to (23) and the remainder (26) were added and uniformly mixed to obtain an oil-in-water emulsion.

The liposome composition of the obtained oil-in-water emulsion was excellent in stability, and crystallization of ceramides and phytosterols was not confirmed. In addition, it is also excellent in effects such as moisture blocking property, luster, firmness, and the like. In addition, the weighted average of the IOB value of the contained component (D) was 3.2. Also, [(A)/(B)]=6, [(D)/(B)]=60, and [(D)/{(A)+(B)}]=8.6.

<Example 2-14 Oil-in-water cream containing liposome composition> (prescription) [mass%] (1) Phospholipids (component (A)) 3.0 (2) Phytosterol Note 1 (Component (B)) 0.5 (3) Ceramide 2 Note 2 (Component (C)) 0.05 (4) Glycerin (ingredient (D)) 12 (5) 1,3-Butanediol (component (D)) 10 (6) Dipropylene glycol (ingredient (D)) 2.0 (7) Water remaining (liposome composition 40%) (8) Hydrogenated isobutylene Note 7 3.0 (9) Lauroylglutamate bis(octyldodecyl/phytosterol/behenyl) ester Note 8 0.4 (10) Tocopherol 0.02 (11) Triethylhexanoin 2.0 (12) Lauryl polyglycerin-3 polydimethylsiloxyethyl polydimethylsiloxane Note 9 0.1 (13) Cetearyl Alcohol 0.8 (14) (Acrylates/acrylic acid (C10-30) crosslinked polymer 0.2 (15) Carbomer 0.2 (16) Xanthan gum 0.1 (17) Hydroxypropyl methylcellulose 0.01 (18) Sodium hydroxide 0.15 (19) Succinic acid (ingredient (E')) 0.03 (20) Disodium succinate (ingredient (E')) 0.15 (21) Disodium hydrogen phosphate (ingredient (E')) 0.03 (22) Sodium dihydrogen phosphate (ingredient (E')) 0.3 (23) Hydrolyzed Yeast Protein Note 4 (Ingredient (F')) 0.1 (24) Sodium benzoate 0.003 (25)Spice 0.2 (26)Ethanol 3.0 (27)EDTA-2Na 0.05 (28) Phenoxyethanol 0.5 (29) Water remaining Note 7: PARLEAM 18 (manufactured by NOF) Note 8: ELDEW PS-306 (manufactured by AJINOMOTO CO., INC.) Note 9: KF-6105 (manufactured by Shin-Etsu Chemical Co., Ltd.) (preparation method) A: Heat ingredients (1)~(6) to 80°C and mix them uniformly. B: Component (7) was heated to 80°C. C: Slowly add B to A and disperse with a disperser. D: Cool C to room temperature and perform high-pressure treatment with a fine fluid homogenizer to obtain a liposome composition. E: Ingredients (8)~(13) were heated to 70°C and mixed uniformly. F: A part of ingredients (27), (28) and (29) was heated to 70° C. and uniformly mixed. G: Add F to E, stir and emulsify with a disperser. H: After cooling G to room temperature, D, components (14) to (26) and the remaining (29) were added and uniformly mixed to obtain an oil-in-water cream.

The liposome composition of the obtained oil-in-water cream was excellent in stability, and crystallization of ceramides and phytosterols was not confirmed. In addition, it is also excellent in effects such as moisture blocking property, luster, firmness, and the like. In addition, the weighted average of the IOB value of the contained component (D) was 3.7. Also, [(A)/(B)]=6, [(D)/(B)]=48, and [(D)/{(A)+(B)}]=6.9.

<Example 2-15 Oil-in-water cream containing liposome composition> (prescription) [mass%] (1) Hydrogenated soybean phospholipids (ingredient (A)) 3.0 (2) Phytosterol Note 1 (Component (B)) 0.5 (3) Ceramide 2 Note 2 (Component (C)) 0.05 (4) Glycerin (ingredient (D)) 6.0 (5) 1,3-butanediol (component (D)) 6.0 (6) Remaining amount of water (liposome composition 40%) (7) Hydrogenated soybean phospholipids 2.5 (8) Glycerin 10 (9) 1,3-Butanediol 3.0 (10) Lauryl Glutamate Bis(Octyldodecyl/Phytosteryl/Behenyl) Ester Note 8 1.0 (11) Phytosterol Oleate 0.5 (12) Diphenylsiloxyphenyl trimethicone 1.0 (13) Dimethicone (100cs) 1.0 (14) Cetearyl Alcohol 0.8 (15) (Acrylates/acrylic acid (C10-30) crosslinked polymer 0.2 (16) Xanthan gum 0.1 (17) Hydroxypropyl methylcellulose 0.01 (18) Sodium hydroxide 0.15 (19) Water remaining (20) Methyl Gluceth-10 (methyl glucose-10) 3.0 (21) EDTA-2Na 0.05 (22) Phenoxyethanol 0.5 (23)Spice 0.2 (preparation method) A: Heat ingredients (1)~(5) to 80°C and mix them uniformly. B: Component (6) was heated to 80°C. C: Slowly add B to A and disperse with a disperser. D: Cool C to room temperature and perform high-pressure treatment with a fine fluid homogenizer to obtain a liposome composition. E: Ingredients (7) to (14) were heated to 70°C and mixed uniformly. F: Components (15)~(21) were heated to 70° C. and mixed uniformly. G: Add F to E, stir and emulsify with a disperser. H: After cooling G to room temperature, D, components (22) and (23) were added and uniformly mixed to obtain an oil-in-water cream.

The liposome composition of the obtained oil-in-water cream was excellent in stability, and crystallization of ceramides and phytosterols was not confirmed. In addition, it is also excellent in moisture blocking properties, luster, firmness, and richness in use. In addition, the weighted average of the IOB value of the contained component (D) was 3.8. Also, [(A)/(B)]=6, [(D)/(B)]=24, and [(D)/{(A)+(B)}]=3.4.

<Example 2-16 Beauty serum containing liposome composition> (prescription) [mass%] (1) Hydrogenated soybean phospholipids (ingredient (A)) 3.0 (2) Phytosterol Note 1 (Component (B)) 0.5 (3) Ceramide 2 (component (C)) 0.01 (4) Glycerin (ingredient (D)) 5.0 (5) 1,3-butanediol (ingredient (D)) 7.5 (6) Succinic acid (ingredient (E)) 0.01 (7) Disodium succinate (ingredient (E)) 0.05 (8) Purified water remaining amount (liposome composition 60%) (9) Hydrogenated soybean phospholipids 4.5 (10)POE(30)Phytosterols 3.0 (11) Dipropylene glycol 20 (12) EDTA-2Na 0.05 (13) Purified water remaining (Double Membrane Microcellular Composition 10%) (14) Carrageenan Note 10 0.1 (15) Purified water remaining (16) Ethanol 4.0 Note 10: CARRAGEENAN J (manufactured by Xudong Chemical Industry Co., Ltd.) (preparation method) A: Heat ingredients (1)~(5) to 80°C and mix them uniformly. B: Components (6) to (8) were heated to 80°C. C: Slowly add B to A and disperse with a disperser. D: Cool C to room temperature and perform high-pressure treatment with a fine fluid homogenizer to obtain a liposome composition. E: Components (9)-(11) were heated to 80° C. and mixed uniformly. F: Components (12), (13) were heated to 80° C. and mixed uniformly. G: Add F to E, and stir with a disperser to obtain a double-layer membrane microcellular structure dispersion. H: After cooling G to room temperature, add D, pre-mixed and dissolved ingredients (14), (15) and (16) and mix uniformly to obtain a beauty serum.

The liposome composition of the obtained beauty essence was excellent in stability, and crystallization of ceramides and phytosterols was not confirmed. In addition, it is also excellent in moisture blocking properties, luster, firmness, and richness in use. In addition, the weighted average of the IOB values of the contained component (D) was 3.5. Also, [(A)/(B)]=6, [(D)/(B)]=25, and [(D)/{(A)+(B)}]=3.6.

This application is based on Japanese Patent Application No. 2021-31283 filed on February 27, 2021, and its disclosure is referred to and incorporated in its entirety.

(none)

Claims (12)

A liposome composition, containing the following components (A) ~ (D): (A) phospholipids; (B) phytosterols; (C) ceramides; (D) Component (d1) is selected from one or more polyols with an IOB value of 1.8 to 3.5, and/or component (d2) is selected from one or more polyols with an IOB value of 4.5 to 5.5 2 or more; The weighted average of the IOB values shown for each of the aforementioned components (D) based on the content mass ratio is greater than 2.0 and less than 5.0. The liposome composition according to claim 1, wherein the content mass ratio [(D)/(B)] of the aforementioned component (D) to the aforementioned component (B) is 10 or more. The liposome composition as claimed in item 1 or 2, wherein the aforementioned component (D) contains at least the aforementioned component (d1), and the content mass ratio of the aforementioned component (d1) relative to the aforementioned component (B) [(d1)/(B )] is 10~40. The liposome composition according to any one of claims 1 to 3, wherein the aforementioned component (d1) is at least one selected from the group consisting of dipropylene glycol, propylene glycol and 1,3-butanediol, and The aforementioned component (d2) is glycerin. The liposome composition according to any one of claims 1 to 4, wherein the aforementioned component (D) contains the aforementioned component (d1) and the aforementioned component (d2), the content of the aforementioned component (d1) is 3 to 20% by mass, and the aforementioned Content of component (d2) is 8-15 mass %, and the content mass ratio [(d1)/(d2)] of the said component (d1) with respect to the said component (d2) is 0.2-2. The liposome composition according to any one of claims 1 to 5, wherein the content mass ratio [(A)/(B)] of the aforementioned component (A) relative to the aforementioned component (B) is 1-30. The liposome composition according to any one of claims 1 to 6, wherein the content mass ratio of the aforementioned component (D) relative to the total amount of the aforementioned component (A) and the aforementioned component (B) [(D)/{(A )+(B)}] is 1~20. The liposome composition according to any one of claims 1 to 7, which includes liposomes, and the lipid system is obtained by adding water-based components to the mixture obtained by mixing the aforementioned components (A) to (D). A cosmetic or skin external preparation containing the liposome composition according to any one of Claims 1 to 8. The cosmetic or skin external preparation according to claim 9, which contains one or more kinds of ingredients (E') selected from organic acids or inorganic acids, and salts thereof (but, as the organic acid or inorganic acid system Aroma compounds are excluded). The cosmetic or skin external preparation according to claim 10, wherein the aforementioned component (E') is one or more selected from succinic acid and its salts. The cosmetic or skin external preparation according to any one of claims 9 to 11, which contains component (F') hydrolyzed yeast protein.