KR20230150260A - liposome composition - Google Patents

Abstract

[Project] Suppress crystal precipitation of ceramides and sterols, achieve excellent stability over time (crystallization inhibition effect of ceramides and phytosterols, stability of liposome composition) over a wide temperature range, and moisturizing effect due to moisture occlusive properties, and also achieve To provide a liposome composition with excellent gloss and elasticity.
[Solutions] The following components (A) to (D); (A) Phospholipids (B) Phytosterols (C) Ceramides (D) Component (d1) one or two or more types selected from polyhydric alcohols with an IOB value of 1.8 to 3.5 and/or component (d2) with an IOB value of 4.5 to 4.5. A liposome composition containing one or two or more types selected from polyhydric alcohols of 5.5, and having a weighted average value of the IOB value shown by each of the components (D) based on the content mass ratio, which is greater than 2.0 and less than 5.0.

Description

liposome composition

The present invention relates to liposome compositions.

It is known that human skin causes various skin problems depending on age, for example, dryness and roughness due to a decrease in the barrier function of the skin, and blemishes and sagging due to a decrease in skin elasticity. Until now, there are technologies that improve the barrier function by applying ceramides or sterols, which are keratinocyte interstitial lipids, to the skin, or products that relieve aging concerns such as freckles and sagging by forming a film on the skin and giving it shine and elasticity. Many are being developed.

Since ceramides and sterols were discovered as effective ingredients for improving the skin's barrier function, attempts have been made to develop moisturizing agents containing these active ingredients. However, ceramides and sterols have high crystallinity, and from the viewpoint of improving stability and developing a moisturizing effect on the skin, development of cosmetics and external skin preparations that do not cause crystal precipitation was expected. Among them, it is very difficult to stably mix it into a lotion-based preparation using water as a medium. Therefore, research into techniques for stably mixing these highly crystalline ceramides and sterols into cosmetics in an aqueous medium is often conducted.

Until now, in order to stably blend ceramides and sterols, a technology for combining ceramides and sterols with linear saturated fatty acids to form a liquid crystal composition has been disclosed (see Patent Document 1). In addition, as a technology for stabilizing highly crystalline components such as ceramides, a technology for encapsulating ceramides in liposomes formed of phospholipids and polyethylene glycol fatty acid esters and developing liposomes with excellent stability in emulsion compositions is disclosed (patent document) 2).

In addition, for skin whose elasticity has decreased due to aging, a technology is being developed that is excellent in reducing skin sagging by providing elasticity using oil-soluble and water-soluble film formers. For example, , a high-viscosity emulsion, isotridecyl isononanoate, and polyethylene glycol are combined to form an oil-in-water emulsified cosmetic (see Patent Document 3).

Japanese Patent Publication No. 2020-109074 Japanese Patent Publication No. 2011-32229 Japanese Patent Publication No. 2007-261971

However, since the liquid crystal composition disclosed in Patent Document 1 contains linear fatty acids, there were cases where the moisturizing effect was not sufficiently exerted from the viewpoint of safety and compatibility with the skin. In addition, in the liquid crystal composition, there are cases where stability over time, such as at low temperatures or temperature cycles, is insufficient, and the effects such as moisturizing effect, gloss, and elasticity are not sufficiently exhibited.

In addition, in the technology disclosed in Patent Document 2, although the stability of ceramides was excellent, the moisturizing effect of ceramides alone was sometimes not sufficient. In addition, in liposome compositions, the stability over time in a wide temperature range such as low temperature, temperature cycle, and high temperature may be insufficient, and the moisturizing effect, gloss, and elasticity effects may not be sufficiently exerted.

In the technology disclosed in Patent Document 3, improvement in elasticity was observed by providing elasticity, but there were cases where usability, such as stickiness and gloss due to the inclusion of a water-soluble film forming agent, was not sufficient. Additionally, there were cases where the moisturizing effect was not sufficiently exerted.

In this way, in the prior art, techniques for suppressing crystallization in compositions and cosmetics containing ceramides and sterols have been disclosed, but the moisturizing effect is sometimes insufficient, and there are cases where the moisturizing effect is insufficient, and the effects of gloss and elasticity are achieved simultaneously. It was difficult. In addition, there were cases where the temporal stability was insufficient in a wide temperature range such as low temperature, temperature cycle, and high temperature, assuming various usage environments. In addition, in order to increase gloss and elasticity, a technology of additionally containing ingredients such as film forming agents has been reported, but there has been concern about destabilization of the liposome composition due to coexisting ingredients.

In other words, the present invention provides excellent temporal stability, especially in a wide temperature range such as low temperature, temperature cycle, and high temperature (crystallization inhibition effect of ceramides and phytosterols and stability of liposome composition), and moisturizing effect due to moisture occlusive properties. The purpose is to provide a liposome composition that is obtained and has excellent gloss and elasticity.

The present inventor conducted intensive research to solve the above problems and found that by applying to the skin a liposome composition containing ceramides and using phytosterol as a component constituting the lipid bilayer, in addition to the moisturizing effect of ceramides, It was discovered that the liposome composition forms an occlusive film on the skin and suppresses moisture evaporation, thereby providing a moisturizing effect due to excellent moisture occlusive properties. Additionally, it was found that the effects of gloss and elasticity on the skin were excellent. On the other hand, phytosterols and/or ceramides are concerned about dissolution in coexisting solvents, and the elution of phytosterols from the liposome composition causes destabilization of the liposome composition and precipitation of crystals derived from phytosterols and/or ceramides, thereby maintaining stability over time. It was extremely difficult to do. However, by setting the polar balance of the polyhydric alcohol contained in the liposome composition to a specific range, it became possible to suppress the crystallization of phytosterol and/or ceramides while suppressing the elution of phytosterol, and the formation of a liposome composition with excellent stability over time was confirmed. It has been done.

The present inventor combines phospholipids, phytosterols, ceramides, and polyhydric alcohols with a specific IOB value, and sets the polar balance of the polyhydric alcohols in a specific range to achieve excellent moisture blocking in addition to stability over time (especially stability over a wide temperature range). We discovered a product that was excellent in usability in terms of moisturizing effect, glossiness, and elasticity, and completed the present invention.

That is, the present invention provides the following.

[One]

The following components (A) to (D);

(A) Phospholipids

(B) Phytosterol

(C) Ceramides

(D) Component (d1) one or two or more types selected from polyhydric alcohols with an IOB value of 1.8 to 3.5 and/or component (d2) one or two or more types selected from polyhydric alcohols with an IOB value of 4.5 to 5.5.

It is a liposome composition that contains and the value obtained by weighting the IOB value shown by each component (D) based on the content mass ratio is greater than 2.0 and less than 5.0.

[2]

The liposome composition described in [1], wherein the mass ratio [(D)/(B)] of component (D) to component (B) is 10 to 60.

[3]

[1] or [2] wherein component (D) contains at least component (d1) and the mass ratio [(d1)/(B)] of component (d1) to component (B) is 10 to 40. It is a liposome composition described in .

[4]

Any one of [1] to [3], wherein component (d1) is at least one selected from the group consisting of dipropylene glycol, propylene glycol, and 1,3-butylene glycol, and component (d2) is glycerin. It is a liposome composition described in section.

[5]

Component (D) contains component (d1) and component (d2), the content of component (d1) is 3 to 20 mass%, the content of component (d2) is 8 to 15 mass%, and component (d2) The liposome composition according to any one of [1] to [4], wherein the mass ratio [(d1)/(d2)] of (d1) is 0.2 to 2.

[6]

The liposome composition according to any one of [1] to [5], wherein the mass ratio [(A)/(B)] of component (A) to component (B) is 1 to 30.

[7]

Any of [1] to [6] where the content mass ratio of component (D) to the total amount of component (A) and component (B) [(D)/{(A)+(B)}] is 1 to 20. It is a liposome composition described in one paragraph.

[8]

The liposome composition according to any one of [1] to [7], comprising a liposome obtained by adding an aqueous component to a mixture obtained by mixing components (A) to (D).

[9]

It is a cosmetic or external skin preparation containing the liposome composition according to any one of [1] to [8].

[10]

In addition, component (E') is a cosmetic or external skin preparation according to [9], containing one or more types selected from organic acids or inorganic acids and salts thereof (however, aroma compounds as organic acids or inorganic acids are excluded). .

[11]

The cosmetic or external skin preparation according to [10], wherein the component (E') is one or two or more selected from succinic acid and salts thereof.

[12]

Additionally, the cosmetic or external skin preparation according to any one of [9] to [11] contains hydrolyzed yeast protein as component (F').

Additionally, the present invention also provides the following forms.

[13]

The liposome composition according to any one of [1] to [8], wherein the mass ratio [(B)/(C)] of component (B) to component (C) is 1 to 100.

The liposome composition of the present invention has excellent stability over a wide temperature range (crystallization inhibition effect of ceramides and phytosterols and stability of the liposome composition), and can also provide a moisturizing effect due to excellent moisture occlusive properties. Additionally, the liposome composition of the present invention is excellent in gloss and elasticity.

Hereinafter, embodiments of the present invention will be described. Additionally, the present invention is not limited to the following embodiments. In this specification, “X to Y” indicating a range includes X and Y and means “X to Y or less.”

In addition, in this specification, “liposome composition” means containing spherical closed vesicles (liposomes) having a lipid bimolecular membrane in an aqueous solvent, and Maltese crosses are observed by observation under a polarizing microscope. Additionally, the liposome composition preferably contains liposomes obtained by mixing the components (components (A) to (D) and aqueous components) required to form liposomes. The liposome composition includes, for example, liposomes formed by adding an aqueous component to a mixture obtained by mixing components (A) to (D).

(Ingredient (A): Phospholipid)

The component (A) phospholipid used in the present invention is contained as the main component that forms the lipid bimolecular membrane of the liposome composition. Such phospholipids are not particularly limited as long as they are used in ordinary cosmetics, quasi-drugs, pharmaceuticals, etc., and examples include soy-derived phospholipids, soy-derived hydrogenated phospholipids (hydrogenated soy phospholipids), soy-derived lysophospholipids, and soy-derived hydrogenated phospholipids. Examples include lysophospholipids, egg yolk-derived phospholipids, egg yolk-derived hydrogenated phospholipids, egg yolk-derived lysophospholipids, and egg yolk-derived hydrogenated lysophospholipids. One or two or more types of these phospholipids can be used as needed, and more preferably, Examples include hydrogenated phospholipids derived from soybeans, hydrogenated lysophospholipids derived from soybeans, hydrogenated phospholipids derived from egg yolk, and hydrogenated lysophospholipids derived from egg yolk, and more preferably, hydrogenated phospholipids derived from soybeans. These phospholipids can be used one type or in combination of two or more types as needed. In the present invention, the moisturizing effect of phospholipids themselves can synergize with ceramides and phytosterols to provide the liposome composition of the present invention with a moisturizing effect due to water-occluding properties.

The content of component (A) in the liposome composition of the present invention is not particularly limited, but is preferably 0.5 to 20% by mass (hereinafter simply expressed as “%”), and more preferably more than 1% and not more than 20%. And, it is more preferable that it is 1 to 15%, and it is even more preferable that it is 3 to 10%. This range is more preferable because the stability of the liposome composition, the effect of suppressing crystals of ceramides and phytosterols, and the moisture blocking properties (moisturizing properties), gloss, and elasticity are more excellent. In this application, the content of the component refers to the total amount when multiple types of the component are included.

(Ingredient (B): Phytosterol)

Component (B) phytosterol used in the present invention is a type of sterol, and together with component (A), it constitutes a lipid bimolecular membrane. Additionally, when component (B) phytosterol is included in the liposome composition in combination with component (C) ceramides, water blocking properties, gloss, and elasticity are improved. Such phytosterols are components contained in trace amounts in plants such as soybeans and rape seeds, and are a mixture of multiple sterols such as β-sitosterol, campesterol, stigmasterol, and brassicasterol. In the present invention, component (B) contributes to the stability of the lipid bimolecular membrane structure, and by combining it, the stability of liposomes can be improved. In addition, since it has a larger molecular weight than other sterols such as cholesterol and is a mixture of multiple sterols, it can provide gloss and elasticity to the liposome composition of the present invention. Additionally, by combining it with ceramides to form a liposomal composition containing phytosterol, an occlusive film is formed on the skin and moisture evaporation is suppressed, thereby providing a moisturizing effect due to excellent moisture occlusive properties. Commercially available products of phytosterol include Phytosterol QI (manufactured by Eisai Food Chemicals). In addition, in the present invention, it is also possible to use it as a premix with component (A). Commercially available products of phospholipid/phytosterol mixtures include PHYTOPRESOME (Nippon Seika Chemical Co., Ltd.). Additionally, component (B) phytosterol does not include phytosterol derivatives such as polyoxyethylene phytosterol.

The content of component (B) in the liposome composition of the present invention is preferably 0.05% or more, more preferably 0.1% or more, and even more preferably exceeding 0.1%, from the viewpoint of moisture occlusiveness, gloss and elasticity, It is particularly preferable that it is 0.3% or more. The content of component (B) in the liposome composition of the present invention is not particularly limited, but is preferably 0.05 to 2%, more preferably 0.1 to 1.5%, further preferably 0.1 to 1%, and 0.1%. It is more preferable that it is more than 1% or less, and 0.2 to 1.0% is especially preferable. This range is more preferable because the liposome composition is superior in terms of stability, moisture blocking properties, and gloss and elasticity.

In the present invention, the combination of component (A) and component (B) constituting the lipid bimolecular membrane of the liposome composition is important. In the present invention, the content ratio [(A)/(B)] of component (A) to component (B) is not particularly limited, but is preferably 1 to 30, and more preferably 1 to 20. , it is more preferable that it is 2 to 10, it is even more preferable that it is 2 to 6, it is especially preferable that it is more than 2 and not more than 6, and it is especially preferable that it is 3 to 6. The mass ratio of component (A) to component (B) [(A)/(B)] refers to the ratio of each component constituting the skeleton of the liposome. This range is more preferable because the stability of the liposome composition, the effect of suppressing crystals of ceramides and phytosterols, and the water blocking properties, gloss, and elasticity are more excellent.

(Ingredient (C): Ceramides)

The component (C) ceramides used in the present invention contain at least one long-chain straight-chain and/or branched alkyl or alkenyl group, at least two or more hydroxyl groups, and one or more amide groups (and/or amino groups) in the molecule. It is a nonionic amphiphilic substance having a , or a derivative in which a phosphatidylcholine residue or a sugar residue is bonded to the hydroxyl group of the nonionic amphiphilic substance, and may be a natural extract or a synthetic product. For example, natural ceramides such as sphingosine, phytosphingosine, and their long-chain fatty acid amides such as ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, and ceramide 6; Sphingophospholipids such as sphingosine, sphingomyelin, a phospholipid derivative of phytosphingosine, and phytosphingomyelin; Examples of these glycosides include sphingoglycolipids such as cerebroside and ganglioside, and phytosphingolipids, and one or two or more of these can be used in combination. Among these, from the viewpoint of moisturizing effect and stability of the liposome composition, natural ceramides are preferable, and ceramide 2 and ceramide 3 are especially preferable. Commercially available products of natural ceramides include, for example, Ceramide I, Ceramide III, Ceramide VI (manufactured by EVONIC), Ceramide TIC-001 (manufactured by Takasago Plastics Co., Ltd.), CERAMIDE 2 (manufactured by Croda Japan), and CERAMIDE3 (manufactured by Croda Japan). (manufactured by Cosmo Palm Corporation), Ceracare AC45 (manufactured by NFC Corporation), etc.

The content of component (C) in the liposome composition of the present invention is not particularly limited, but is preferably 0.001 to 2%, more preferably 0.005 to 1%, further preferably 0.005 to 0.5%, and 0.005 to 0.005%. It is more preferable that it is more than 0.5% or less, and it is especially preferable that it is 0.01 to 0.5%. This range is more preferable because the stability of the liposome composition, the effect of suppressing crystals of ceramides and phytosterols, and the moisture blocking properties, gloss, and elasticity are more excellent.

In the liposome composition containing ceramides of the present invention, the combination of components (A) to (C) is important. The mass ratio [{(A)+(B)}/(C)] of the total amount of component (A) and component (B) to component (C) is not particularly limited, but the stability and water blocking properties of the liposome composition are not limited. And from the viewpoint of gloss, elasticity, etc., it is preferably 5 to 1000, more preferably 10 to 700, and even more preferably 30 to 500.

In the liposome composition of the present invention, the combination of component (B) and component (C) is important because it is related to moisture occlusiveness, gloss, elasticity, etc. In the liposome composition, the content ratio [(B)/(C)] of component (B) to component (C) is not particularly limited, but is preferably 1 to 200, and more preferably 1 to 100. , it is more preferable that it is more than 1 and less than or equal to 100, and it is even more preferable that it is 10 to 100. This range is more preferable because the liposome composition has better stability, moisture blocking properties, gloss, and elasticity.

(Component (D): (d1) one or two or more types selected from polyhydric alcohols with an IOB value of 1.8 to 3.5 and/or (d2) one or two types of polyhydric alcohols with an IOB value of 4.5 to 5.5 more)

The component (D) used in the present invention is a polyhydric alcohol with a component (d1) IOB value of 1.8 to 3.5 and/or a polyhydric alcohol with a component (d2) IOB value of 4.5 to 5.5. Component (d1) a polyhydric alcohol with an IOB value of 1.8 to 3.5 and/or component (d2) a polyhydric alcohol with an IOB value of 4.5 to 5.5 has a structure having two or more hydroxyl groups in the molecule. The IOB value in the present invention is a value obtained based on the organic conceptual diagram (Atsushi Fujita, Prediction of Organic Compounds and Organic Conceptual Diagram, Area of Chemistry VOL. 11, No. 10 (1957) 719-715). More specifically, in this organic conceptual diagram, with respect to the physical and chemical properties of a compound, the degree of physical properties mainly due to Van Der Waals forces is referred to as “organic,” and the degree of physical properties mainly due to electrical affinity is referred to as “inorganic.” It is a value defined and expressed as 」. The IOB value is an indicator of the balance between inorganic and organic, and is expressed as IOB value = inorganic value/organic value. A compound with a larger value can be said to have more hydrophilic properties and more polar properties. Among them, for component (d1), the IOB value is preferably 1.8 to 3.3, more preferably 1.8 to 2.5, from the viewpoint of the stability of the liposome composition, the effect of suppressing crystals of ceramides and phytosterol, etc., and the IOB value of component (d2) is preferably 1.8 to 3.3. In this case, the IOB value is preferably 4.5 to 5.0.

Components (d1) of such IOB values include dipropylene glycol (IOB value = 1.8), 1,3-butylene glycol (IOB value = 2.5), diglycerol (IOB value = 3.5), and propylene glycol (IOB value = 3.5). 3.3), etc., and from the viewpoint of the stability of the liposome composition, the effect of suppressing crystals of ceramides and phytosterol, etc., it is one or two or more types selected from dipropylene glycol, propylene glycol, and 1,3-butylene glycol. It is preferable, and it is more preferable that it is one or two types selected from dipropylene glycol and 1,3-butylene glycol, and it is still more preferable that it is 1,3-butylene glycol. In addition, the component (d2) includes glycerin (IOB value = 5.0), sorbitol (IOB value = 5.0), and from the viewpoint of the stability of the liposome composition and the effect of suppressing crystals of ceramides and phytosterols, glycerin is preferred. desirable. These may be used individually, or two or more types may be used in combination.

The content of component (D) in the liposome composition is not particularly limited, but is preferably 10 to 40%, more preferably 15 to 30%, and still more preferably 20 to 30%. This range is more preferable because the stability of the liposome composition and the effect of suppressing crystals of ceramides and phytosterols are superior.

The content of component (d1) in the liposome composition is not particularly limited, but is preferably 1 to 25%, more preferably 3 to 20%, and still more preferably 6 to 18%. This range is more preferable because the stability of the liposome composition and the effect of suppressing crystals of ceramides and phytosterols are superior.

Additionally, the content of component (d2) in the liposome composition is not particularly limited, but is preferably in the range of 5 to 20%, more preferably in the range of 8 to 15%, and even more preferably in the range of 8 to 12%. desirable. This range is more preferable because the stability of the liposome composition and the effect of suppressing crystals of ceramides and phytosterols are superior.

In a preferred embodiment, from the viewpoint of stability over time in a wide temperature range of the liposome composition, component (d1) is at least selected from the group consisting of dipropylene glycol, propylene glycol, and 1,3-butylene glycol. It is one type, and the ingredient (d2) is glycerin.

In the present invention, it is preferable that component (D) contains at least component (d1), and it is more preferable to use components (d1) and (d2) together. In the present invention, from the viewpoint of the stability of the liposome composition, the effect of suppressing crystals of ceramides and phytosterols, etc., the content mass ratio of component (d1) to component (d2) [(d1)/(d2)] is 0.2 to 2. It is preferable, it is more preferable that it is 0.6-1.8, and it is still more preferable that it is 1-1.6.

Additionally, in the present invention, since the solubility of ceramides and phytosterol is good, crystal precipitation is suppressed, and a stable liposome composition is obtained, it is preferable that component (D) contains at least 1,3-butylene glycol. From the viewpoint of the stability of the liposome composition, the effect of suppressing the crystallization of ceramides and phytosterol, etc., the mass ratio of 1,3-butylene glycol contained in component (D) [(1,3-butylene glycol)/(d) ] is preferably 0.1 to 1, more preferably 0.2 to 0.8, and still more preferably 0.4 to 0.7.

In addition, polyhydric alcohols with low IOB values have excellent affinity with phytosterols, so there is concern about destabilization of the liposome composition due to elution of phytosterols. Therefore, in the liposome composition of the present invention, the polar balance of the component (D) (a value obtained by weighting the IOB value expressed by each of the component (D) based on the contained mass ratio (hereinafter simply referred to as “component (D)) (expressed as “weighted average of IOB values”)} is important. In the present invention, the calculation of the weighted average of the IOB value of component (D) is the product of the content (g) of each polyhydric alcohol corresponding to components (d1) and (d2) of component (D) and each IOB value. The sum is divided by the sum (g) of the content of the polyhydric alcohol (value expressed in the following formula (1)).

Weighted average of the IOB values of component (D)

=[(D1: content × IOB value) + (D2: content × IOB value) + (D3: content × IOB value) + … /(d1+D2+D3+…: content)]… (Equation 1)

In the present invention, the weighted average of the IOB value of component (D) exceeds 2.0 as the lower limit. If the weighted average of the IOB value of component (D) is 2.0 or less, phytosterol may elute over time, and as a result, there is concern about precipitation of ceramides and phytosterol and collapse of the liposome composition. Additionally, the weighted average of the IOB values of component (D) is less than 5.0 as the upper limit. If the weighted average of the IOB value of component (D) is 5.0 or more, phytosterol is not dissolved, the formation of the liposome composition is insufficient, and the stability of the liposome composition tends to decrease. Additionally, a sufficient sense of elasticity is not obtained. The weighted average of the IOB value of component (D) is preferably 2.3 or more, more preferably 2.5 or more, more preferably 3.0 or more, even more preferably more than 3.2, and especially preferably more than 3.3. It is preferable that it is 4.6 or less, and it is more preferable that it is 4.0 or less. This range is more preferable because the stability of the liposome composition, the effect of suppressing crystals of ceramides and phytosterols, and the moisture blocking property are superior.

Additionally, in the liposome composition of the present invention, it is important to consider the solubility of component (B) with respect to component (D). In the present invention, the content mass ratio [(D)/(B)] of component (D) to component (B) is not particularly limited, but is preferably 10 or more, more preferably 15 or more, and 20 or more. It is more desirable than When the mass ratio of component (D) to component (B) [(D)/(B)] is more than the above lower limit, the stability over time (crystallization inhibition effect of ceramides and phytosterols and stability of the liposome composition) is further improved. . The content ratio [(D)/(B)] of component (D) to component (B) is, in preferred order, 300 or less, 250 or less, 100 or less, 60 or less, and 50 or less. This range is more preferable because it provides better moisture blocking properties, gloss, and elasticity. The mass ratio [(D)/(B)] of component (D) to component (B) is preferably 10 to 250, more preferably 10 to 100, and even more preferably 10 to 60, It is more preferable that it is 15-60, and it is especially preferable that it is 15-50. Additionally, the combination with component (d1), which has excellent solubility with component (B), can also be appropriately set from the viewpoint of stability of the liposome composition, etc. In the present invention, the content mass ratio [(d1)/(B)] of component (d1) to component (B) is not particularly limited, but is preferably 5 to 150, preferably 10 to 100, It is more preferable that it is 10 to 50, and it is even more preferable that it is 10 to 40. This range is more preferable because the stability of the liposome composition is superior.

In the liposome composition of the present invention, the mass ratio of component (D) to the total amount of component (A) and component (B) [(D)/{(A)+(B)}] is not particularly limited. The range is preferably 1 to 20, more preferably 3 to 17, and still more preferably 3 to 10. This range is more preferable because the stability of the liposome composition, the effect of suppressing crystals of ceramides and phytosterols, and the moisture blocking properties, gloss, and elasticity are more excellent.

In the liposome composition of the present invention, the ratio of constituent components (A) to (D) can be appropriately set. In the liposome composition of the present invention, the mass ratio of the total amount of component (A), component (B), and component (C) to component (D) [{(A) + (B) + (C)} / (D )] is not particularly limited, but is preferably 0.05 to 1, more preferably 0.1 to 0.7, and still more preferably 0.1 to 0.5. This range is more preferable because the stability of the liposome composition, the effect of suppressing crystals of ceramides and phytosterols, and the moisture blocking properties, gloss, and elasticity are more excellent.

An aqueous solvent is used as a dispersion medium for the liposome composition of the present invention. The aqueous solvent contains water as its main component. Here, the main component refers to water containing 50% or more (upper limit 100%), preferably 60% or more, more preferably 70% or more, and even more preferably 80% or more. There are no particular restrictions on the water, and for example, in addition to purified water, hard water, soft water, mineral water, tap water, sea water, deep ocean water, electrolytic alkaline ion water, electrolytic acid ion water, ion water, and water clusters can be used. The content of water is not particularly limited and can be contained in appropriate amounts of other ingredients. As the aqueous solvent, other aqueous solvents miscible with water may be used. As other aqueous solvents, lower alcohols such as ethanol and 2-propanol may be used, and one or two or more of these may be used in combination. In the liposome composition of the present invention, (part of) component (D) is contained in an aqueous solvent.

In the present invention, the content of component (D) in the aqueous solvent and component (D) as a whole is not particularly limited, but is preferably 10 to 60%, more preferably 20 to 60%, and even more preferably is 20 to 50%. This range is more preferable because it is superior in terms of the stability of the liposome composition, the effect of suppressing crystals of ceramides and phytosterols, and the moisture blocking property. The total content of the aqueous solvent and component (D) in the liposome composition of the present invention is not particularly limited, but is preferably 40 to 99%, and more preferably 50 to 98%.

Additionally, the water content in the liposome composition is preferably 20 to 80%, more preferably 30 to 75%, and the water content in the aqueous solvent is preferably 40 to 90%, and 40 to 80%. It is more preferable that it is 50 to 80%. In addition, from the viewpoint of the stability of the liposome composition, the effect of suppressing the crystallization of ceramides and phytosterols, and the moisture blocking property, the mass ratio of component (D) and water contained in the liposome composition [component (D)/water] is 0.2 to 2. It is preferable, it is more preferable that it is 0.2-1.5, and it is still more preferable that it is 0.2-1.

(Component (E): one or two or more selected from organic acids or inorganic acids and salts thereof)

The liposome composition of the present invention may further use one or two or more types selected from component (E) organic acids or inorganic acids and salts thereof. By using component (E), even when stored for a long period of time, especially at high temperature, crystals of ceramides and phytosterols do not precipitate and phytosterols do not elute, resulting in superior stability over time.

The component (E) used in the present invention is not particularly limited, but the organic acids include citric acid, lactic acid, formic acid, acetic acid, oxalic acid, malic acid, tartaric acid, succinic acid, glycolic acid, aspartic acid, glutamic acid, and polyglutamic acid. The inorganic acids include phosphoric acid. , hydrochloric acid, sulfuric acid, boric acid, etc. Examples of salts of organic acids or inorganic acids include alkali metal salts of the above acids, such as sodium and potassium salts, and alkanolamine salts, such as triethanolamine salts. Among these, from the viewpoint of the stability of the liposome composition and the effect of inhibiting the crystallization of ceramides and phytosterols, it is more preferable to use one or two or more types selected from phosphoric acid, citric acid, succinic acid and salts thereof, and from the viewpoint of stability of the liposome composition It is more preferable that it is one or two or more types selected from succinic acid and salts thereof. Specifically, it is preferable that it is succinic acid and/or sodium succinate, and it is especially preferable to use a combination of succinic acid and sodium succinate. In addition, component (E) does not contain aromatic compounds such as benzoic acid.

The content of component (E) in the liposome composition of the present invention is not particularly limited, but is preferably 0.0001 to 1%, more preferably 0.001 to 1%, and still more preferably 0.001 to 0.6%. This range is more preferable because the stability of the liposome composition and the effect of suppressing crystals of ceramides and phytosterols are superior. Additionally, the content ratio [(E)/(C)] of component (E) to component (C) is not particularly limited, but is preferably 0.1 to 15, more preferably 0.1 to 12, and 0.2. It is more preferable that it is ~5. This range is more preferable because the stability of the liposome composition and the effect of suppressing crystals of ceramides and phytosterols are superior.

(Ingredient (F): Hydrolyzed yeast protein)

The liposome composition of the present invention can be made into a liposome composition excellent in water blocking properties and/or stability by further using component (F) hydrolyzed yeast protein. In the present invention, hydrolyzed yeast protein is obtained by self-digestion or acid hydrolysis of yeast belonging to Saccharomyces cerevisiae, Candida, etc., or by extraction from dried yeast powder with water and glycerin, etc. These include water-soluble extracts obtained by placing yeast in a medium and irradiating it with ultraviolet rays. In the present invention, any of the above can be used as the hydrolyzed yeast protein, but it is preferable that it is obtained from yeast belonging to Candida. Commercially available products include CHRONOGEN YST (manufactured by ASHLAND).

The content of component (F) in the liposome composition of the present invention is not particularly limited, but is 0.0001 to 1% from the viewpoint of the stability of the liposome composition, the effect of suppressing crystals of ceramides and phytosterols, and/or the water blocking property, etc. It is preferable, it is more preferable that it is 0.0005-0.5%, and it is still more preferable that it is 0.0005-0.1%. This range is more preferable because it can further provide a moisturizing effect while maintaining the stability over time of the liposome composition.

In the present invention, the component (E) and/or component (F) may be contained in the liposome composition, or may be added separately from the composition to prepare as a cosmetic or external skin preparation, but the effects of the present invention (especially stability over time) ), it is preferable that component (E) and/or component (F) are added separately from the liposome composition and prepared as a cosmetic or external skin preparation.

The liposome composition of the present invention preferably has a pH of 5 to 8 from the viewpoint of liposome stability, etc. By setting this range, a liposome composition with excellent stability, moisture blocking properties, gloss, and elasticity can be obtained. In addition, the pH measurement in this application was measured at 20°C, and a glass electrode type hydrogen ion concentration meter (manufactured by Horiba Seisakusho Co., Ltd.) was used for the measurement.

To prepare the liposome composition of the present invention, conventional methods known to those skilled in the art can be used. Although it is not particularly limited, for example, components (A) to (D) are heated in advance and mixed uniformly, and the heated aqueous component is added thereto while stirring. The aqueous component essentially includes the aqueous solvent and optionally includes other aqueous components. Component (E) and component (F) are the respective aqueous components. Here, the formation of a lipid bimolecular film can be confirmed by performing a treatment on the obtained agent and observing the presence of Maltese crosses under a polarizing microscope under orthogonal Nicols. This is followed by high-pressure treatment using, for example, a high-pressure homogenizer.

The average particle diameter of the liposome composition of the present invention is not particularly limited, but from the viewpoint of more preferably exhibiting the effect of the present invention, it is preferably 50 to 300 nm, more preferably 100 to 250 nm, and 100 to 100 nm. It is more preferable that it is 200 nm. The average particle diameter of the liposome composition of the present invention adopts the value measured in Examples.

The liposome composition of the present invention can use optional additives as long as they do not interfere with the effects of the present invention and the formation of the liposome composition. Such optional ingredients include, specifically, emulsions, alcohols, powders, water-soluble polymers, film formers, surfactants other than component (A), oil-soluble gelling agents, organic modified clay minerals, resins, ultraviolet absorbers, preservatives, and antibacterial agents. , fragrance, antioxidant, pH adjuster other than component (E), chelating reagent, skin active ingredient, etc.

Particularly in liposome compositions, stabilizing aids such as surfactants, higher alcohols, and higher fatty acids are used for the purpose of increasing the stability of the liposome composition. These ingredients can also be used in the liposome composition of the present invention, but there are concerns about safety on the skin, reduced moisture blocking properties, and further reduced usability such as stickiness due to the stabilizing agent. Therefore, in the liposome composition of the present invention, the content of the stabilizing agent is preferably 1% or less, more preferably 0.5% or less, and even more preferably 0% (not included). Here, the stable aid refers to surfactants such as anionic surfactants, cationic surfactants, nonionic surfactants, amphoteric surfactants other than component (A), cetostearyl alcohol, behenyl alcohol, etc. Higher alcohols, higher fatty acids such as palmitic acid and stearic acid, etc. can be mentioned. Among them, in the present invention, when containing a stabilizing auxiliary agent, from the viewpoint of stability of the liposome composition, water blocking property, etc., it is preferable that the stabilizing auxiliary agent is a nonionic surfactant, and a nonionic surfactant having a polyoxyalkylene group is preferred. It is more preferable to be

Additionally, in compositions containing ceramides, an oil agent that dissolves ceramides may be used to suppress crystal precipitation of ceramides. In the liposome composition of the present invention, an emulsion can be used, but phytosterols forming closed endoplasmic reticulum are dissolved (eluted) in the emulsion, resulting in a decrease in the stability of the liposome composition, precipitation of crystals, and a decrease in gloss and elasticity due to stickiness, etc. Since there are concerns, the content of the oil agent is preferably 1% or less, more preferably 0.5% or less, and even more preferably 0% (not contained). Here, the emulsion is not particularly limited as long as it is commonly used in cosmetics, quasi-drugs, pharmaceuticals, etc. Specifically, vegetable oils such as olive oil, castor oil, mink oil, macadamia nut oil, avocado oil, and meadowfoam oil; Jojoba oil, diisobutyl adipate, 2-hexyldecyl adipate, di-2-heptylundecyl adipate, alkyl glycol monoisostearate, isocetyl isostearate, trimethylolpropane triisostearate, Ethylene glycol di-2-ethylhexanoate, neopentyl glycol di-2-ethylhexanoate, trimethylolpropane tri-2-ethylhexanoate, pentaerythritol tetra-2-ethylhexanoate, cetyl 2-ethylhexanoate, Oleyl oleate, octyldodecyl oleate, decyl oleate, neopentyl glycol dicaprate, triethyl citrate, 2-ethylhexyl succinate, isocetyl stearate, butyl stearate, diisopropyl sebacate, di-2-sebacate. Ethylhexyl, cetyl lactate, myristyl lactate, isopropyl palmitate, 2-ethylhexyl palmitate, 2-hexyldecyl palmitate, 2-heptylundecyl palmitate, dipentaerythritol fatty acid ester, isono. Isononyl acid acid, isotridecyl isononanoate, isopropyl myristic acid, isopropyl palmitate, 2-octyldodecyl myristic acid, 2-hexyldecyl myristic acid, myristic acid, hexyl dimethyloctanoate Decyl, ethyl laurate, hexyl laurate, 2-ethylhexyl methoxycinnamate, diisostearyl malate, glyceryl tri-2-ethylhexanoate, glyceryl tri(caprylic capric) acid, tricar Glyceryl phricate, glyceryl triisostearate, diglyceryl diisostearate, diglyceryl triisostearate, diglyceryl tetraisostearate, decaglyceryl decaisostearate, glyceryl triisopalmitate , Glyceryl trimyistic acid, Diglyceryl myristic isostearate, Tritridecyl trimellitic acid, N-lauroyl-L-glutamic acid-2-octyldodecyl ester, N-lauroyl-L- Ester oils such as glutamic acid di(phytostearyl·2-octyldodecyl); Silicone oils such as low degree of polymerization dimethylpolysiloxane, high degree of polymerization dimethylpolysiloxane, methylphenylpolysiloxane, decamethylcyclopentasiloxane, octamethylcyclotetrasiloxane, and fluorine-modified organopolysiloxane; Fluorine-based ungulates such as perfluorodecane, perfluorooctane, and perfluoropolyether; Hydrocarbons such as isododecane, isohexadecane, light liquid isoparaffin, medium paraffin, heavy liquid isoparaffin, α-olefin oligomer, squalene, polyisobutylene, and polybutene; lanolin derivatives such as lanolin acetate, isopropyl lanolin fatty acid, and lanolin alcohol; Higher alcohols such as isostearyl alcohol and octyldodecanol; Higher fatty acids such as isostearic acid and oleic acid; Oil-based gelling agents such as dextrin fatty acid ester, sucrose fatty acid ester, starch fatty acid ester, 12-hydroxystearic acid, aluminum stearate, inulin stearate, and calcium stearate; and oil-soluble ultraviolet absorbers such as ethyl para-aminobenzoate, 2-ethylhexyl para-methoxycinnamic acid, 4-tert-butyl-4'-methoxydibenzoylmethane, and oxybenzone.

The liposome composition of the present invention obtained as described above can be used as is as a cosmetic or external skin preparation, or can be combined with another ingredient to make a cosmetic or external skin preparation. For example, skin care cosmetics such as lotion, emulsion, cream, eye cream, serum, massage, pack, hand cream, body lotion, body cream, cosmetics such as cosmetic base cosmetics, external solution, external gel, and cream. , ointments, liniments, lotions, poultices, warning agents, sprays, and aerosols can be used for external skin use. The content of the liposome composition in cosmetics or external skin preparations is not particularly limited, but for example, the content of the liposome composition in cosmetics or external skin preparations is preferably 20 to 80%, more preferably 30 to 70%, and even more preferably 40 to 60%. . Additionally, the formulation is not particularly limited, and various formulations such as water-based cosmetics and oil-in-water cosmetics can be used. In this specification, external skin preparations include quasi-drugs and pharmaceuticals.

A water-based cosmetic is a preferred formulation for the cosmetic or external skin preparation of the present invention. In this specification, water-based cosmetic means a formulation in which the aqueous phase composed of an aqueous solvent is a continuous phase and does not substantially contain an oil agent. In this specification, substantially no oil agent means that the content of oils other than component (B) and component (C) in the cosmetic is less than 0.5%, preferably less than 0.1%, more preferably less than 0.05%. means that Here, the emulsions include those listed above.

In cosmetics, from the viewpoint of the stability of the liposome composition, the effect of suppressing the crystallization of ceramides and phytosterols, etc., component (E') one or two or more types selected from organic acids or inorganic acids and their salts (however, the organic acid or inorganic acid may contain a fragrance) Compounds are excluded), and component (F') contains hydrolyzed yeast protein, so it is preferable to contain one or two or more types selected. In the present specification, in order to distinguish from component (E) and component (F) contained in the liposome composition, one or two or more types selected from organic acids or inorganic acids and salts thereof added to cosmetics or external skin preparations are used as components ( E') and hydrolyzed yeast protein as the component (F').

The content of component (E') in the cosmetic or external skin preparation is not particularly limited, but is preferably 0.0001 to 1% in the cosmetic or external skin preparation from the viewpoint of the stability of the liposome composition and the effect of suppressing crystals of ceramides and phytosterol. It is more preferably 0.001 to 1%, more preferably 0.001 to 0.6%, even more preferably 0.001% or more and less than 0.6%, and especially preferably 0.05 to 0.5%. In addition, the mass ratio [(E')/(C)] of component (E') to component (C) in cosmetics or external skin preparations is not particularly limited, but determines the stability of the liposome composition, ceramides, and phytosterols. From the viewpoint of the suppression effect, etc., it is preferably 0.1 to 15, more preferably 0.1 to 12, and even more preferably 0.2 to 5. Other specific aspects of component (E') are the same as component (E) described in the liposome composition above.

The content of component (F') in the cosmetic or external skin preparation is not particularly limited, but from the viewpoint of the stability of the liposomal composition, the effect of suppressing crystals of ceramides and phytosterol, and moisture occlusiveness, the content of component (F') in the cosmetic or external skin preparation is 0.0001 to 1. It is preferable that it is %, it is more preferable that it is 0.0005-0.5%, it is still more preferable that it is 0.0005-0.1%, it is still more preferable that it is 0.0005% or more and less than 0.1%, and it is especially preferable that it is 0.0005-0.08%. Other specific aspects of component (F') are the same as component (F) described in the liposome composition above.

Cosmetics or external skin preparations may contain ingredients that are usually added to cosmetics or external skin preparations. Such ingredients include emulsions, surfactants (anionic surfactants, nonionic surfactants, amphoteric surfactants, cationic surfactants), thickeners (gelling agents, polymers), colorants, powders other than colorants, and ethanol. lower alcohols, polyhydric alcohols, ultraviolet absorbers, pH adjusters, antioxidants, metal chelating agents, preservatives, fragrances, and various drugs. Additionally, cosmetics or external skin preparations may contain polyhydric alcohols or water of the same component separately from the components (A) to (F) and water-based components used when forming the liposome composition, but these are components used in the liposome composition. It is distinguished from (A) to (F). In other words, when a polyhydric alcohol such as 1,3-butylene glycol is added to a cosmetic or external skin preparation separately from the liposome composition, the polyhydric alcohol such as 1,3-butylene glycol is distinguished from component (D), and the component (D) It is not included in the content of (D).

<Example>

Hereinafter, the present invention will be described in more detail through examples, etc., but the present invention is not limited to the following examples at all.

Liposome composition: Examples 1-1 to 1-14, Comparison 1-1 to 1-4

A liposome composition was prepared according to the following prescription and manufacturing method. For each obtained liposome composition, “average particle diameter”, “moisture occlusiveness”, “temporal stability (5°C and -10⇔20°C/1 month”, “gloss”, and “elasticity” were measured according to the following methods and standards. The results are shown in Table 1 and Table 2.

[Table 1]

[Table 2]

Note 1: Phytosterol Q1 (manufactured by Eisai Food Chemicals)

Note 2: Ceramide TIC-001 (manufactured by Takasago Koryo Corporation)

Note 3: CERAMIDE3 (manufactured by Cosmo Farm)

<Manufacturing method>

A: Components (1) to (9) were heated to 80°C and mixed uniformly.

B: Component (10) was heated to 80°C.

C: B was slowly added to A and dispersed using a despa mixer.

D: After C was cooled to room temperature, it was prepared by high-pressure treatment using a microfluidizer.

<Evaluation>

1. Average particle diameter

Each sample was filled into a plastic cuvette UVette 220-1600 nm (manufactured by Eppendorf), and the average particle diameter was measured using a real-time nanoparticle diameter measuring device (DelsaMax CORE) (manufactured by Beckman Coulter Co., Ltd.).

2. Moisture occlusiveness

The moisture blocking property of the present invention was evaluated by the following method in an environment with a relative humidity of 30RH% and judged by the following three-step judgment criteria.

A: Add 10g of water to a vial bottle (Vials With Rubber Stopper/V-20 Capacity: 20mL).

B: The opening of the vial bottle is blocked with a filter (GLASS MICROFIBER FILTERS diameter: 21 mm), 80 μL of each sample doubled concentrated is applied to the top of the filter, and the weight is measured (initial weight).

C: After leaving for 48 hours, measure the weight of the vial (weight after leaving).

D: Calculate the moisture transpiration rate (%) {[(initial weight-weight after leaving)/(initial weight)]×100}.

3-level decision criteria;

[Judgment]:[Judgment criteria]

◎(Excellent): Moisture transpiration rate is 1.8% or less.

○ (Good): Moisture transpiration rate is more than 1.8% and less than 2.4%

× (not possible): Moisture transpiration rate exceeds 2.4%

3. Stability over time (crystallization inhibition effect of ceramides and phytosterols)

Liposome compositions after being stored for 1 month at constant temperatures of 5°C and -10⇔20°C (24-hour cycle) were examined under an upright microscope (manufactured by Olympus) at a magnification of 400x and an exposure time of 1/200 second. was observed under polarized light. Under polarized light, when ceramides and phytosterols exist as crystals in the composition, they are observed as white shiny substances. Moreover, even if it is not a crystalline substance, if crystallization is in progress, it is observed under a microscope as a gray-scale image as an unclear bright substance of ceramides and phytosterol. Regarding the effect of suppressing ceramides and phytosterol crystals, the presence or absence of crystals derived from ceramides and phytosterols was observed and judged based on the following three-step judgment criteria.

3-level decision criteria;

[Judgment]:[Judgment criteria]

◎ (Excellent): Crystalline substances derived from ceramides and phytosterols are not recognized.

○ (good): Indistinct crystalline substances derived from ceramides and/or phytosterols are recognized.

× (not possible): Crystalline substances derived from ceramides and phytosterols are recognized

4. Stability over time (stability of liposomal composition)

The average particle diameter of each sample after storage for 1 month at a constant temperature of 5°C and -10⇔20°C was measured using the above evaluation method, and the formation and maintenance of the liposome composition was evaluated from the change rate of the average particle diameter compared to immediately after production. And, the stability of the liposome composition was determined based on the following four-step judgment criteria.

4-step judgment criteria;

[Judgment]:[Judgment criteria]

◎(Excellent): Average particle diameter change rate is less than ±20%

○ (Good): Change rate of average particle diameter is ±20% or more and less than ±40%

△ (somewhat impossible): Change rate of average particle diameter is ±40% or more and less than ±60%

× (impossible): Change rate of average particle diameter is ±60% or more

5. Shine and elasticity

After washing the face twice a day in the morning and evening, each sample of the present invention products 1-1 to 1-14 and comparative products 1-1 to 1-4 was measured by a panel of 10 cosmetics experts aged 35 to 50 years to about the size of a grain of rice. They held it in their hands and applied it to their entire face. This was carried out for 2 weeks, and each sample was subjected to a sensory evaluation in 5 stages for gloss and elasticity according to the evaluation criteria (1) below, and the average score of each sample was determined according to the 4-stage evaluation criteria (2) below. .

(1) Evaluation criteria;

[Evaluation Result]:[Rating]

Very Good: 5 points

Good: 4 points

Average: 3 points

Somewhat bad: 2 points

Defective: 1 point

(2) Judgment criteria;

[Judgment]:[Average score]

◎(Excellent): 4.5 or higher

○ (good): 3.5 or more to less than 4.5

△ (somewhat impossible): 1.5 or more ~ 3.5 or more

× (not possible): less than 1.5

As is clear from Tables 1 and 2 above, it was found that the liposome compositions of Examples 1-1 to 1-14 were all excellent in liposome composition stability and had an excellent effect in suppressing crystals of ceramides and phytosterol. In addition, it was found that the effects of moisture blocking, gloss, and elasticity were excellent.

On the other hand, as shown in Table 2 above, in Comparative Example 1-1, which did not contain phytosterol, satisfactory thinness was not obtained in terms of moisture occlusiveness, stability over time, and gloss and elasticity of the liposome composition. In Comparative Example 1-2, in which cholesterol was used instead of phytosterol, the stability of the liposome was excellent, but the gloss and elasticity were insufficient. Additionally, in Comparative Example 3, where the weighted average of the IOB value of component (D) was 2.0, crystals derived from ceramides and phytosterols were observed, and destabilization of the liposome composition was confirmed. In Comparative Example 4, where the weighted average of the IOB value of component (D) was 5.0, satisfactory thinness in terms of stability and elasticity of the liposome composition was not obtained. And, the liposome compositions of the obtained examples were all pH 5 to 8.

Preparation of water-based cosmetics: Examples 2-1 to 2-9

An aqueous cosmetic containing the liposome composition was prepared according to the following prescription and production method, and evaluated for “stability over time (50°C/1 month)” using the same methods and standards as above. The results are shown in Table 3.

[Table 3]

Note 4: CHRONOGEN YST (manufactured by ASHLAND)

<Manufacturing method>

A: Components (1) to (6) were heated to 80°C and mixed uniformly.

B: Component (7) was heated to 80°C.

C: B was gradually added to A and dispersed using a despa mixer.

D: After C was cooled to room temperature, it was subjected to high pressure treatment using a microfluidizer to obtain a liposome composition.

E: Components (8) to (15) were mixed uniformly.

F: A cosmetic was prepared by adding D to E and mixing.

<Evaluation>

5. Stability over time (crystallization inhibition effect of ceramides and phytosterols)

Each sample after being stored for 1 month at a constant temperature of 50°C was evaluated using the above methods and standards.

6. Stability over time (stability of liposome composition)

Each sample after being stored for 1 month at a constant temperature of 50°C was evaluated using the above methods and standards.

As is clear from Table 3, the water-based cosmetics of Examples 2-1 to 2-9 all had excellent liposome composition stability even at high temperatures, and were even more excellent in the effect of suppressing crystals of ceramides and phytosterols. In addition, Examples 2-1 to 2-9 were also excellent in terms of stability over time at low temperatures and temperature cycles, moisture blocking properties, glossiness, and elasticity. And, the obtained liposome compositions were all pH 5 to 8.

<Example 2-10 White cloudy lotion containing liposome composition>

(Prescription) [mass%]

(1) Hydrogenated soybean phospholipid (component (A)) 5.5

(2) Phytosterol Note 1 (Component (B)) 1.0

(3) Ceramide 2 Note 2 (Component (C)) 0.02

(4) Glycerin (component (D)) 10

(5) 1,3-butylene glycol (component (D)) 15

(6) Succinic acid (component (E)) 0.0007

(7) Succinic acid 2Na (component (E)) 0.0033

(8) Hydrolyzed yeast protein main 4 (component (F)) 0.001

(9) Water remaining (68.475)

(50% liposome composition)

(10) Hydrolyzed hyaluronic acid 1.0

(11) Tocopherol 0.05

(12) (Acrylate/acrylic acid (C10-30) crosspolymer 0.4

(13) Dipropylene glycol 3.0

(14) Na hydroxide 0.15

(15) Phenoxyethanol 0.5

(16) Benzoic acid Na 0.001

(17) Water remaining (44.899)

(Liposome composition: 100% of components (1) to (9), lotion: 100% of the total of 50% of the liposome composition of components (1) to (9) and 50% of post-additive ingredients (10) to (17), Same in later examples)

(quite)

A: Components (1) to (3) and (5) were heated to 80°C and mixed uniformly.

B: Component (4) heated to 80°C was added to A and mixed uniformly.

C: Components (6) to (9) heated to 80°C were gradually added to B and dispersed using a despa mixer.

D: C was cooled to room temperature and subjected to high pressure treatment using a microfluidizer to obtain a liposome composition. The stability of the liposome composition at 50°C 1M (inhibition of crystallization of ceramides and phytosterols and maintenance of formation of the liposome composition) was ◎ based on the above evaluation criteria.

E: Mixed with D and components (10) to (17) to obtain a cloudy lotion.

The obtained white-clouded lotion had excellent stability of the liposome composition, and precipitation of crystals of ceramides and phytosterol was not observed. In addition, the effects of moisture blocking, gloss, and elasticity were excellent. And the weighted average of the IOB values of the contained component (D) was 3.5. Also, [(A)/(B)]=5.5, [(D)/(B)]=25, [(D)/{(A)+(B)}]=3.8.

<Example 2-11 White cloudy lotion containing liposome composition>

(Prescription) [mass%]

(1) Hydrogenated soybean phospholipid (component (A)) 8.0

(2) Phytosterol Note 1 (Component (B)) 2.0

(3) Ceramide 2 Note 2 (Component (C)) 0.02

(4) Glycerin (component (D)) 11

(5) 1,3-butylene glycol (component (D)) 10

(6) Dipropylene glycol (component (D)) 4.0

(7) Succinic acid (component (E)) 0.01

(8) Succinic acid 2Na (component (E)) 0.05

(9) Hydrolyzed yeast protein main 4 (component (F)) 0.01

(10) Water remaining amount

(60% liposome composition)

(11) Xanthan gum 0.1

(12) Tocopherol 0.05

(13) Carbomer 0.4

(14) Hydroxyethylcellulose 0.2

(15) Na hydroxide 0.15

(16) Phenoxyethanol 0.5

(17) Ethanol 1.0

(18) Benzoic acid Na 0.001

(19) Water remaining amount

(quite)

A: Components (1) to (6) were heated to 80°C and mixed uniformly.

B: Components (7) to (10) were heated to 80°C.

C: B was gradually added to A and dispersed using a despa mixer.

D: C was cooled to room temperature and subjected to high pressure treatment using a microfluidizer to obtain a liposome composition.

E: Mixed with D and components (11) to (19) to obtain a cloudy lotion.

The obtained white-clouded lotion had excellent stability of the liposome composition, and precipitation of crystals of ceramides and phytosterol was not observed. In addition, the effects of moisture blocking, gloss, and elasticity were excellent. And the weighted average of the IOB values of the contained component (D) was 3.5. Also, [(A)/(B)]=4, [(D)/(B)]=12.5, [(D)/{(A)+(B)}]=2.5.

<Example 2-12 Essence containing liposome composition>

(Prescription) [mass%]

(1) Hydrogenated soybean phospholipid (component (A)) 3.0

(2) Phytosterol main 1 (component (B)) 0.5

(3) Ceramide 2 Note 2 (Component (C)) 0.05

(4) Glycerin (component (D)) 10

(5) 1,3-butylene glycol (component (D)) 15

(6) Water remaining amount

(50% liposome composition)

(7) Xanthan gum 0.3

(8) Carbomer 0.3

(9) Hydroxyproline 0.1

(10) Tocopherol 0.02

(11) Succinic acid (component (E')) 0.01

(12) Succinic acid 2Na (component (E')) 0.05

(13) Hydrolyzed yeast protein note 4 (component (F')) 0.05

(14) Benzoic acid Na 0.001

(15) Na hydroxide 0.1

(16) Water remaining amount

(quite)

A: Components (1) to (3) and (5) were heated to 80°C and mixed uniformly.

B: Component (4) heated to 80°C was added to A and mixed uniformly.

C: Component (6) heated to 80°C was gradually added to B and dispersed using a despa mixer.

D: C was cooled to room temperature and subjected to high pressure treatment using a microfluidizer to obtain a liposome composition.

E: Components (7) to (16) were mixed uniformly.

F: D was added to E and mixed uniformly to obtain a cosmetic liquid.

The obtained cosmetic liquid had excellent liposome composition stability, and no precipitation of crystals of ceramides or phytosterols was observed. In addition, the effects of moisture blocking, gloss, and elasticity were excellent. And the weighted average of the IOB values of the contained component (D) was 3.5. Also, [(A)/(B)]=6, [(D)/(B)]=(50), [(D)/{(A)+(B)}]=7.1.

<Example 2-13 Oil-in-water emulsion containing liposome composition>

(Prescription) [mass%]

(1) Hydrogenated soybean phospholipid (component (A)) 3.0

(2) Phytosterol main 1 (component (B)) 0.5

(3) Ceramide 2 Note 2 (Component (C)) 0.05

(4) Glycerin (component (D)) 10

(5) 1,3-butylene glycol (component (D)) 15

(6) Dipropylene glycol (component (D)) 5.0

(7) Water remaining amount

(50% liposome composition)

(8) Hydrogenated polydecene note 5 0.5

(9) Macadamia nut fatty acid phytosteryl main 6 0.5

(10) Tocopherol 0.01

(11) Cetyl 2-ethylhexanoate 1.0

(12) Hardened polyoxyethylene (60) Castor oil 0.8

(13) Cetostearyl alcohol 0.15

(14) (Acrylate/acrylic acid (C10-30) crosspolymer 0.2

(15) Carbomer 0.3

(16) Xanthan gum 0.1

(17) Na hydroxide 0.15

(18) Succinic acid (component (E')) 0.01

(19) Succinic acid 2Na (component (E')) 0.05

(20) Hydrolyzed yeast protein note 4 (component (F') 0.5

(21) Benzoic acid Na 0.015

(22) Fragrance 0.1

(23) Ethanol 2.0

(24) EDTA-2Na 0.05

(25) Phenoxyethanol 0.5

(26) Water remaining amount

Note 5: SILKFLO 364 (manufactured by LIPO CHEMICALS INC.)

Note 6: PLANDOOL-MAS (manufactured by Nippon Seika Chemical Co., Ltd.)

(quite)

A: Components (1) to (6) were heated to 80°C and mixed uniformly.

B: Component (7) was heated to 80°C.

C: B was gradually added to A and dispersed using a despa mixer.

D: C was cooled to room temperature and subjected to high pressure treatment using a microfluidizer to obtain a liposome composition.

E: Components (8) to (13) were heated to 70°C and mixed uniformly.

F: Parts of components (24), (25), and (26) were heated to 70°C and mixed uniformly.

G: F was added to E, stirred with a despa mixer, and emulsified.

H: After cooling G to room temperature, D and the remainder of components (14) to (23) and (26) were added and mixed uniformly to obtain an oil-in-water emulsion.

The obtained oil-in-water emulsion was excellent in stability of the liposome composition, and precipitation of crystals of ceramides and phytosterols was not observed. In addition, the effects of moisture blocking, gloss, and elasticity were excellent. And the weighted average of the IOB values of the contained component (D) was 3.2. Also, [(A)/(B)]=6, [(D)/(B)]=60, [(D)/{(A)+(B)}]=8.6.

<Example 2-14 Oil-in-water cream containing liposome composition>

(Prescription) [mass%]

(1) Phospholipid (component (A)) 3.0

(2) Phytosterol main 1 (component (B)) 0.5

(3) Ceramide (2) Note 2 (Component (C)) 0.05

(4) Glycerin (component (D)) 12

(5) 1,3-butylene glycol (component (D)) 10

(6) Dipropylene glycol (component (D)) 2.0

(7) Water remaining amount

(Liposome composition 40%)

(8) Hydrogenated Isobutene Note 7 3.0

(9) Lauroylglutamic acid di(octyldodecyl/phytosteryl/behenyl) Note 8 0.4

(10) Tocopherol 0.02

(11) Triethylhexanoin 2.0

(12) Laurylpolyglyceryl-3-polydimethylsiloxyethyldimethicone Note 9 0.1

(13) Cetostearyl alcohol 0.8

(14) (Acrylate/acrylic acid (C10-30) crosspolymer 0.2

(15) Carbomer 0.2

(16) Xanthan gum 0.1

(17) Hydroxypropylmethylcellulose 0.01

(18) Na hydroxide 0.15

(19) Succinic acid (component (E')) 0.03

(20) Succinic acid 2Na (component (E')) 0.15

(21) Na monohydrogen phosphate (component (E')) 0.03

(22) Na dihydrogen phosphate (component (E')) 0.3

(23) Hydrolyzed yeast protein note 4 (component (F')) 0.1

(24) Benzoic acid Na 0.003

(25) Fragrance 0.2

(26) Ethanol 3.0

(27) EDTA-2Na 0.05

(28) Phenoxyethanol 0.5

(29) Water remaining amount

Note 7: PARLEAM 18 (manufactured by Nichi Yu)

Note 8: Ldue PS-306 (manufactured by Ajinomoto Corporation)

Note 9: KF-6105 (manufactured by Shinetsu Chemical Co., Ltd.)

(quite)

A: Components (1) to (6) were heated to 80°C and mixed uniformly.

B: Component (7) was heated to 80°C.

C: B was gradually added to A and dispersed using a despa mixer.

D: C was cooled to room temperature and subjected to high pressure treatment using a microfluidizer to obtain a liposome composition.

E: Components (8) to (13) were heated to 70°C and mixed uniformly.

F: Parts of components (27), (28), and (29) were heated to 70°C and mixed uniformly.

G: F was added to E, stirred with a despa mixer, and emulsified.

H: After cooling G to room temperature, D and the remainder of components (14) to (26) and (29) were added and mixed uniformly to obtain an oil-in-water cream.

The obtained oil-in-water cream had excellent stability of the liposome composition, and precipitation of crystals of ceramides and phytosterols was not observed. In addition, the effects of moisture blocking, gloss, and elasticity were excellent. And the weighted average of the IOB values of the contained component (D) was 3.7. Also, [(A)/(B)]=6, [(D)/(B)]=48, [(D)/{(A)+(B)}]=6.9.

<Example 2-15 Oil-in-water cream containing liposome composition>

(Prescription) [mass%]

(1) Hydrogenated soybean phospholipid (component (A)) 3.0

(2) Phytosterol main 1 (component (B)) 0.5

(3) Ceramide 2 Note 2 (Component (C)) 0.05

(4) Glycerin (component (D)) 6.0

(5) 1,3-butylene glycol (component (D)) 6.0

(6) Water remaining amount

(Liposome composition 40%)

(7) Hydrogenated soy phospholipid 2.5

(8) Glycerin 10

(9) 1,3-butylene glycol 3.0

(10) Lauroylglutamic acid di(octyldodecyl/phytosteryl/behenyl) Note 8 1.0

(11) Phytosteryl oleic acid 0.5

(12) Diphenylsiloxyphenyltrimethicone 1.0

(13) Dimethicone (100cs) 1.0

(14) Cetostearyl alcohol 0.8

(15) (Acrylate/acrylic acid (C10-30) crosspolymer 0.2

(16) Xanthan gum 0.1

(17) Hydroxypropylmethylcellulose 0.01

(18) Na hydroxide 0.15

(19) Water remaining amount

(20) Methylgluceth-10 3.0

(21) EDTA-2Na 0.05

(22) Phenoxyethanol 0.5

(23) Fragrance 0.2

(quite)

A: Components (1) to (5) were heated to 80°C and mixed uniformly.

B: Component (6) was heated to 80°C.

C: B was gradually added to A and dispersed using a despa mixer.

D: C was cooled to room temperature and subjected to high pressure treatment using a microfluidizer to obtain a liposome composition.

E: Components (7) to (14) were heated to 70°C and mixed uniformly.

F: Components (15) to (21) were heated to 70°C and mixed uniformly.

G: F was added to E, stirred with a despa mixer, and emulsified.

H: After cooling G to room temperature, D and components (22) and (23) were added and mixed uniformly to obtain an oil-in-water cream.

The obtained oil-in-water cream had excellent stability of the liposome composition, and precipitation of crystals of ceramides and phytosterols was not observed. In addition, it was excellent in terms of moisture blocking properties, glossiness, elasticity, and thickening sensation during use. And the weighted average of the IOB values of the contained component (D) was 3.8. Also, [(A)/(B)]=6, [(D)/(B)]=24, [(D)/{(A)+(B)}]=3.4.

<Example 2-16 Essence containing liposome composition>

(Prescription) [mass%]

(1) Hydrogenated soybean phospholipid (component (A)) 3.0

(2) Phytosterol main 1 (component (B)) 0.5

(3) Ceramide 2 (component (C)) 0.01

(4) Glycerin (component (D)) 5.0

(5) 1,3-butylene glycol (component (D)) 7.5

(6) Succinic acid (component (E)) 0.01

(7) Succinic acid 2Na (component (E)) 0.05

(8) Remaining amount of purified water

(60% liposome composition)

(9) Hydrogenated soy phospholipid 4.5

(10) POE (30) Phytosterol 3.0

(11) Dipropylene glycol 20

(12) EDTA-2Na 0.05

(13) Remaining amount of purified water

(10% Bicell composition)

(14) Carrageenan main 10 0.1

(15) Remaining amount of purified water

(16) Ethanol 4.0

Note 10: Carrageenan J (manufactured by Gyokuto Kagaku Sankyo)

(quite)

A: Components (1) to (5) were heated to 80°C and mixed uniformly.

B: Components (6) to (8) were heated to 80°C.

C: B was gradually added to A and dispersed using a despa mixer.

D: C was cooled to room temperature and subjected to high pressure treatment using a microfluidizer to obtain a liposome composition.

E: Components (9) to (11) were heated to 80°C and mixed uniformly.

F: Components (12) and (13) were heated to 80°C and mixed uniformly.

G: F was added to E, stirred with a despa mixer, and a bi-cell structure dispersion was obtained.

H: After G was cooled to room temperature, D and previously mixed and dissolved components (14), (15), and (16) were added and mixed uniformly to obtain a cosmetic liquid.

The obtained cosmetic liquid had excellent liposome composition stability, and no precipitation of crystals of ceramides or phytosterols was observed. In addition, it was excellent in terms of moisture blocking properties, glossiness, elasticity, and thickening sensation during use. And the weighted average of the IOB values of the contained component (D) was 3.5. Also, [(A)/(B)]=6, [(D)/(B)]=25, [(D)/{(A)+(B)}]=3.6.

This application is based on Japanese Patent Application No. 2021-31283 filed on February 27, 2021, the disclosure of which is hereby incorporated by reference.

Claims (12)

The following components (A) to (D);
(A) Phospholipids
(B) Phytosterol
(C) ceramides, and
(D) Component (d1) one or two or more types selected from polyhydric alcohols with an IOB value of 1.8 to 3.5 and/or component (d2) one or two or more types selected from polyhydric alcohols with an IOB value of 4.5 to 5.5.
Contains, and the value obtained by weighting the IOB value shown by each of the components (D) based on the content mass ratio is greater than 2.0 and less than 5.0,
Liposome composition. According to paragraph 1,
A liposome composition wherein the mass ratio [(D)/(B)] of the component (D) to the component (B) is 10 or more. According to claim 1 or 2,
A liposome composition wherein the component (D) contains at least the component (d1), and the mass ratio of the component (d1) to the component (B) [(d1)/(B)] is 10 to 40. . According to any one of claims 1 to 3,
A liposome composition wherein the component (d1) is at least one selected from the group consisting of dipropylene glycol, propylene glycol, and 1,3-butylene glycol, and the component (d2) is glycerin. According to any one of claims 1 to 4,
The component (D) contains the component (d1) and the component (d2), the content of the component (d1) is 3 to 20% by mass, and the content of the component (d2) is 8 to 15% by mass. and the mass ratio [(d1)/(d2)] of the component (d1) to the component (d2) is 0.2 to 2. According to any one of claims 1 to 5,
A liposome composition wherein the mass ratio [(A)/(B)] of the component (A) to the component (B) is 1 to 30. According to any one of claims 1 to 6,
A liposome composition wherein the content ratio of the component (D) to the total amount of the component (A) and the component (B) [(D)/{(A)+(B)}] is 1 to 20. According to any one of claims 1 to 7,
A liposome composition comprising a liposome obtained by adding an aqueous component to a mixture obtained by mixing the above components (A) to (D). A cosmetic or external skin preparation containing the liposome composition according to any one of claims 1 to 8. According to clause 9,
Component (E') A cosmetic or external skin preparation containing one or more types selected from organic acids or inorganic acids and salts thereof (however, aroma compounds as organic acids or inorganic acids are excluded). According to clause 10,
A cosmetic or external skin preparation, wherein the component (E') is one or two or more selected from succinic acid and salts thereof. According to any one of claims 9 to 11,
Component (F') A cosmetic or external skin preparation containing hydrolyzed yeast protein.