TW202242896A - Electrolytic pump device and method for drug delivery solve the problem that the gas is generated in one direction and accumulates on the bottom of the electrode body - Google Patents

Electrolytic pump device and method for drug delivery solve the problem that the gas is generated in one direction and accumulates on the bottom of the electrode body Download PDF

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TW202242896A
TW202242896A TW110113621A TW110113621A TW202242896A TW 202242896 A TW202242896 A TW 202242896A TW 110113621 A TW110113621 A TW 110113621A TW 110113621 A TW110113621 A TW 110113621A TW 202242896 A TW202242896 A TW 202242896A
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chamber
finger
dimensional electrode
electrode pair
cathode
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TWI785565B (en
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鄭宗杰
賴俊如
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國立高雄科技大學
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Abstract

The present invention provides an electrolytic pump device for drug delivery, which includes: an accommodating area, a casing, a medicine bag, an electrolytic pump unit, a printed circuit board, and a power supply unit. The advantageous effect is that, by the improvement of the three-dimensional structure of the electrolytic pump unit, the electrolytic pump unit can generate a gas more efficiently and solve the problem that the gas is generated in one direction and accumulates on the bottom of the electrode body.

Description

用以藥物傳遞之電解幫浦的裝置及方法 Device and method for electrolysis pump for drug delivery

本發明屬於一種用以藥物傳遞之電解幫浦的裝置及方法,特別是關於元件及功能的改良,用以提升電解幫浦產生的氣體用於藥物傳遞的效能。 The invention belongs to a device and method of an electrolytic pump for drug delivery, in particular to the improvement of components and functions to enhance the performance of the gas generated by the electrolytic pump for drug delivery.

常見的給藥途徑包括耳、眼、鼻、口服、直腸、氣霧、腸胃道、靜脈內投服、肺、黏膜穿透、皮膚穿透及局部給藥,而對於癌症、慢性病或心血管疾病的高血壓患者來說,容易面臨需要長期、定時且指定劑量的服藥,也易碰到忘記服藥而發生危及性命的情況發生。為了造福廣大社會大眾,醫療技術在日新月異的改良之下,已開發植入式的藥物遞送系統,讓患者免於不斷打針或忘記服藥而危及性命的風險中。 Common routes of administration include ear, eye, nose, oral, rectal, aerosol, gastrointestinal, intravenous administration, lung, mucosal penetration, skin penetration and topical administration, and for cancer, chronic disease or cardiovascular disease For hypertensive patients, it is easy to face the need for long-term, regular and specified doses of medication, and it is also easy to encounter life-threatening situations due to forgetting to take medication. In order to benefit the general public, under the rapid improvement of medical technology, an implantable drug delivery system has been developed to save patients from the life-threatening risks of repeated injections or forgetting to take medicine.

在植入式藥物遞送系統的技術領域中,常見於經由半導體製程的平面式電極以產生氣體來達到藥物傳遞的功能,然而,經由半導體製程的平面式電極存在以下技術缺陷,首先,平面式電極產生的氣體有方向性的問題,且因平面電極結構的關係,造成電極產生的氣體易於積聚於平面電極的底部而降低電化學反應及藥物傳遞的效能,再者,經由半導體製 程的平面式電極,其製作成本昂貴。 In the technical field of implantable drug delivery systems, it is common to use planar electrodes through semiconductor processes to generate gas to achieve the function of drug delivery. However, planar electrodes through semiconductor processes have the following technical defects. First, planar electrodes The generated gas has a directional problem, and due to the structure of the planar electrode, the gas generated by the electrode tends to accumulate at the bottom of the planar electrode, thereby reducing the performance of the electrochemical reaction and drug delivery. The planar electrodes of the process are expensive to manufacture.

上述缺點顯現,習知平面式電極於進行電化學反應用以藥物傳遞的過程中所衍生的種種問題。因此,如何解決用以藥物傳遞的電極其產生氣體的方向性問題以及如何延長用以藥物傳遞的電極之電力供應續航時間,以利於提升電極之電化學反應的氣體產生及藥物傳遞的效能,為各方所面臨與重視之課題,是故,現有技術確實有待提出更佳解決方案之必要性。 The above-mentioned disadvantages show various problems arising from the conventional planar electrodes in the process of carrying out electrochemical reactions for drug delivery. Therefore, how to solve the problem of the directionality of the gas generated by the electrode used for drug delivery and how to prolong the power supply life of the electrode used for drug delivery, so as to improve the gas generation of the electrochemical reaction of the electrode and the efficiency of drug delivery, are The issues that all parties are facing and attaching great importance to, therefore, the existing technology really needs to propose a better solution.

基於先前技術存在的技術上缺陷性問題,本發明之目的在於,提供一種用以藥物傳遞之電解幫浦之裝置及方法,以改善及提升電極之電化學反應的氣體產生及藥物傳遞的效能。 Based on the technical deficiencies in the prior art, the object of the present invention is to provide an electrolytic pump device and method for drug delivery, so as to improve and enhance the performance of gas generation and drug delivery in the electrochemical reaction of electrodes.

首先,本發明之主要目的為提供一種用以藥物傳遞之電解幫浦之裝置,該裝置包括:一容置區、一殼體、一藥袋、一電解幫浦單元、一印刷電路板以及一電源供應單元。 First of all, the main purpose of the present invention is to provide an electrolytic pump device for drug delivery, which device includes: an accommodating area, a casing, a medicine bag, an electrolytic pump unit, a printed circuit board and a Power supply unit.

其中,該容置區包括一第一腔室、一第二腔室及一第一隔膜,該第一隔膜位於該第一腔室及該第二腔室之間。 Wherein, the accommodating area includes a first chamber, a second chamber and a first diaphragm, and the first diaphragm is located between the first chamber and the second chamber.

其中,該殼體環繞且包覆該容置區,且該殼體的材料可為剛性材料、柔性材料、或剛性材料與柔性材料的複合材料。 Wherein, the casing surrounds and covers the accommodating area, and the material of the casing can be rigid material, flexible material, or composite material of rigid material and flexible material.

其中,該藥袋用以容置實質上為液體的藥物。 Wherein, the medicine bag is used for accommodating medicine which is substantially liquid.

其中,該電解幫浦單元位於該第一腔室且靠近該藥袋設置, 該電解幫浦單元包括至少一立體式電極對,該立體式電極對具有一陰極板及一陽極板,其中該陰極板具有複數陰極指狀結構,該陽極板具有複數陽極指狀結構;該等陰極指狀結構及該等陽極指狀結構交錯配置而構成一指叉型結構,其中該等陰極指狀結構及該等陽極指狀結構之間具有一指狀流道。詳細說明的是,本發明之立體式電極對,由於其立體結構上的優勢,使得立體電極對於電化學反應的接觸面積增加,且該立體式電極對的任一表面在電化學反應中皆可產生氣體,解決了習知平面式電極僅能在單一方向產生氣體的缺陷,此外,具有指叉型結構的該立體式電極對,可減少該立體式電極對的所需容置空間。 Wherein, the electrolytic pump unit is located in the first chamber and is set close to the medicine bag, The electrolytic pump unit includes at least one three-dimensional electrode pair, the three-dimensional electrode pair has a cathode plate and an anode plate, wherein the cathode plate has a plurality of cathode finger structures, and the anode plate has a plurality of anode finger structures; The cathode finger structures and the anode finger structures are interlaced to form an interdigitated structure, wherein there is a finger flow channel between the cathode finger structures and the anode finger structures. In detail, the three-dimensional electrode pair of the present invention, due to the advantages of its three-dimensional structure, increases the contact area of the three-dimensional electrode for the electrochemical reaction, and any surface of the three-dimensional electrode pair can be used in the electrochemical reaction. Gas generation solves the defect that the conventional planar electrodes can only generate gas in a single direction. In addition, the three-dimensional electrode pair with an interdigitated structure can reduce the required accommodation space of the three-dimensional electrode pair.

其中,該印刷電路板位於該第二腔室且電性連接該電解幫浦單元。 Wherein, the printed circuit board is located in the second chamber and is electrically connected to the electrolytic pump unit.

其中,電源供應單元位於該第二腔室且電性連接該印刷電路板。 Wherein, the power supply unit is located in the second chamber and electrically connected to the printed circuit board.

進一步地,該指狀流道的其一開口朝向該藥袋,較佳者該指狀流道的其一開口正投影於該藥袋,且該指狀流道的其一開口連接該指狀流道與容置於該第一腔室的至少部分電解液。如此結構、相對位置的設計,該指狀流道可提供該立體式電極對所產生的至少部分氣體經由該指狀流道逸散於該第一腔室。因此,該指狀流道的結構設計有利於該立體電極對產生的氣體移走,且該指狀流道的其一開口朝向該藥袋可有助於移走的氣體作動鄰近該藥袋的電解液,進而壓縮該藥袋用以藥物傳遞。 Further, one opening of the finger-shaped flow channel faces the medicine bag, preferably one opening of the finger-shaped flow channel is orthographically projected on the medicine bag, and one opening of the finger-shaped flow channel is connected to the finger-shaped flow channel. The flow channel and at least part of the electrolyte contained in the first chamber. With such a structure and design of relative positions, the finger-shaped flow channel can provide at least part of the gas generated by the three-dimensional electrode pair to escape into the first chamber through the finger-shaped flow channel. Therefore, the structural design of the finger-shaped flow channel is conducive to the removal of the gas generated by the three-dimensional electrode pair, and one opening of the finger-shaped flow channel faces the medicine bag, which can help the removed gas to actuate the gas adjacent to the medicine bag. Electrolyte, which in turn compresses the pouch for drug delivery.

進一步地,該指狀流道填充有孔隙的親水性材料,有助於該 立體電極對產生的氣體脫離其表面。 Further, the finger channel is filled with porous hydrophilic material, which contributes to the The gas generated by the three-dimensional electrode pair escapes from its surface.

進一步地,該立體式電極對遠離該藥袋的一側的構型包括弧形、矩形或尖角形。藉由前述技術特徵,使得該立體電極對產生的氣體易於脫離其表面且作動電解液,減少氣泡積聚於該立體電極對的底部而影響電解幫浦在輔助藥物傳遞的效能。 Further, the configuration of the side of the three-dimensional electrode pair away from the medicine bag includes arc, rectangle or pointed shape. With the aforementioned technical features, the gas generated by the three-dimensional electrode pair is easy to escape from its surface and activate the electrolyte, reducing the accumulation of bubbles at the bottom of the three-dimensional electrode pair and affecting the performance of the electrolytic pump in assisting drug delivery.

進一步地,該陰極板及該陽極板表面分別塗佈親水性材料以增進氣泡脫離該陰極板及該陽極板表面。 Further, the surfaces of the cathode plate and the anode plate are respectively coated with hydrophilic materials to promote the detachment of air bubbles from the surfaces of the cathode plate and the anode plate.

進一步地,該電解幫浦單元具有複數立體式電極對,該等立體式電極對以串聯方式排列且該等立體式電極對電性連接於該印刷電路板。 Further, the electrolytic pump unit has a plurality of three-dimensional electrode pairs, the three-dimensional electrode pairs are arranged in series, and the three-dimensional electrode pairs are electrically connected to the printed circuit board.

進一步地,該第一腔室更包括一電源流路,該電源流路分別電性連接該電解幫浦單元及該印刷電路板。 Further, the first chamber further includes a power flow path, and the power flow path is electrically connected to the electrolytic pump unit and the printed circuit board respectively.

進一步地,該殼體開設一開口,該開口係以供一導管插設且該導管穿入該藥袋,其中該藥袋中的藥物可自該容置區經由該導管及該開口而朝該殼體外部釋放,或藥物可自該殼體的外部經由該導管及該開口而朝該藥袋進行填充。 Further, the casing defines an opening for inserting a catheter and passing the catheter into the medicine bag, wherein the medicine in the medicine bag can pass through the catheter and the opening from the containing area toward the The housing is externally released, or drug can be filled towards the pouch from the outside of the housing through the conduit and the opening.

進一步地,該殼體開設兩開口,兩開口係以供導管插設且導管穿入該藥袋,其中,該藥袋中的藥物可自該容置區經由其一導管及其一開口而朝該殼體外部釋放,此外,藥物可自該殼體的外部經由另一導管及另一開口而朝該藥袋進行填充。 Further, the housing is provided with two openings, the two openings are used for inserting the catheter and passing the catheter into the medicine bag, wherein the medicine in the medicine bag can flow from the containing area through a catheter and an opening to the The housing is externally released and, furthermore, drug can be filled towards the pouch from the outside of the housing via another conduit and another opening.

進一步地,該殼體的材料為剛性材料、柔性材料或剛性材料 與柔性材料的複合材料,且殼體表面塗佈生物相容性材料。 Further, the material of the shell is rigid material, flexible material or rigid material Composite material with flexible material, and the shell surface is coated with biocompatible material.

此外,本發明提供另一種用以藥物傳遞之電解幫浦之裝置,其以一第二隔膜區取代前述藥袋之容置藥物的功能。具體來說,該容置區更包括一第二隔膜,該第二隔膜位於該第一腔室,且,部分之殼體與該第二隔膜圍繞以形成該第二隔膜區,再者,該第二隔膜的材料可為軟性材料。 In addition, the present invention provides another electrolytic pump device for drug delivery, which uses a second diaphragm area to replace the drug containing function of the aforementioned drug bag. Specifically, the accommodating area further includes a second diaphragm, the second diaphragm is located in the first chamber, and part of the housing is surrounded by the second diaphragm to form the second diaphragm area, and the The material of the second diaphragm can be soft material.

此外,本發明之另一目的為提供一種用以藥物傳遞之電解幫浦之裝置的藥物傳遞方法,該方法包括下列步驟:將一藥袋/或該第二隔膜區及一電解幫浦單元相鄰設置於一殼體內之一第一腔室中,其中該殼體內更包含一相鄰於該第一腔室之第二腔室,其中該電解幫浦單元包括至少一立體式電極對,該立體式電極對具有一陰極板及一陽極板,該陰極板具有複數陰極指狀結構,該陽極板具有複數陽極指狀結構,該等陰極指狀結構及該等陽極指狀結構交錯配置而構成一指叉型結構,其中該等陰極指狀結構及該等陽極指狀結構之間具有一指狀流道;將一第一隔膜設置於該第一腔室及該第二腔室之間;將一印刷電路板及一電源供應單元設置於該殼體內的第二腔室中,且該電源供應單元電性連接該印刷電路板;及將該印刷電路板電性連接該電解幫浦單元;其中,在電化學反應,該立體式電極對的任何一面係用以產生氣體,當該第一腔室充填指定體積的電解液,且至少部分的氣體可經由該指狀流道逸散於該第一腔室,該立體式電極對產生的氣體佔據了至少部分的電解液體積,藉此令至少部分的電解液及/或至少部分的氣體可壓縮藥袋/或該第二隔膜區。 In addition, another object of the present invention is to provide a drug delivery method for an electrolysis pump device for drug delivery, the method comprising the following steps: combining a drug bag and/or the second diaphragm area with an electrolysis pump unit Adjacently disposed in a first chamber in a housing, wherein the housing further includes a second chamber adjacent to the first chamber, wherein the electrolytic pump unit includes at least one three-dimensional electrode pair, the The three-dimensional electrode pair has a cathode plate and an anode plate, the cathode plate has a plurality of cathode finger structures, the anode plate has a plurality of anode finger structures, and the cathode finger structures and the anode finger structures are staggered to form a structure An interdigitated structure, wherein there is a finger-shaped flow channel between the cathode finger structures and the anode finger structures; a first diaphragm is arranged between the first chamber and the second chamber; a printed circuit board and a power supply unit are arranged in the second chamber in the casing, and the power supply unit is electrically connected to the printed circuit board; and the printed circuit board is electrically connected to the electrolysis pump unit; Wherein, in the electrochemical reaction, any side of the three-dimensional electrode pair is used to generate gas. When the first chamber is filled with a specified volume of electrolyte, at least part of the gas can escape to the In the first chamber, the gas generated by the three-dimensional electrode pair occupies at least part of the volume of the electrolyte, so that at least part of the electrolyte and/or at least part of the gas can compress the medicine bag and/or the second membrane region.

整體來說,本發明之有益功效至少包括: Overall, the beneficial effects of the present invention at least include:

1.藉由立體電極對的結構改良,提升電解幫浦產生氣體的效能,同時,立體電極對具有的指狀結構係用以提供指狀流道,利於氣體自電極表面移走而作動鄰近該藥袋的電解液,壓縮該藥袋用以藥物傳遞。 1. By improving the structure of the three-dimensional electrode pair, the performance of the electrolytic pump to generate gas is improved. At the same time, the finger-like structure of the three-dimensional electrode pair is used to provide a finger-like flow channel, which is beneficial for the gas to move away from the electrode surface and move adjacent to the electrode. The electrolyte of the pouch, which is compressed for drug delivery.

2.藉由立體電極對的結構改良,可有效率的將消耗電能轉換為產生的氣體,有助於減少電解幫浦產生氣體的所需電能,提升藥物傳遞系統使用上的續航力。 2. With the improvement of the structure of the three-dimensional electrode pair, the consumed electric energy can be efficiently converted into the generated gas, which helps to reduce the required electric energy for the electrolysis pump to generate the gas, and improves the endurance of the drug delivery system in use.

3.藉由該立體式電極對遠離該藥袋的一側的構型包括弧形、矩形或尖角形的技術特徵,使得該立體電極對產生的氣體易於脫離其表面且作動電解液,減少氣泡積聚於該立體電極對的底部而影響電解幫浦在輔助藥物傳遞的效能。 3. The configuration of the side of the three-dimensional electrode pair far away from the medicine bag includes the technical features of arc, rectangle or sharp angle, so that the gas generated by the three-dimensional electrode pair is easy to break away from its surface and activate the electrolyte, reducing air bubbles Accumulation at the bottom of the three-dimensional electrode pair affects the efficiency of the electrolytic pump in assisting drug delivery.

100:用以藥物傳遞之電解幫浦之裝置 100: Electrolysis pump device for drug delivery

110:容置區 110: Containment area

111:第一腔室 111: The first chamber

112:第二腔室 112: second chamber

113:第一隔膜 113: First diaphragm

120:殼體 120: shell

130:藥袋 130: medicine bag

140:電解幫浦單元 140: Electrolytic pump unit

141:立體式電極對 141: three-dimensional electrode pair

142:陰極板 142: cathode plate

143:陽極板 143: anode plate

144:陰極指狀結構 144: cathode finger structure

145:陽極指狀結構 145: Anode finger structure

146:指叉型結構 146: Interdigitated structure

147:指狀流道 147: finger flow channel

148:指狀流道的其一開口 148: One of the openings of the finger channel

150:印刷電路板 150: printed circuit board

160:電源供應單元 160: Power supply unit

170:電源流路 170: Power flow path

180:開口 180: opening

190:親水性材料 190: Hydrophilic material

210:電極接頭 210: electrode connector

310:弧形 310: Arc

320:矩形 320: rectangle

S510~S540:步驟 S510~S540: steps

[圖1]為一剖面圖,說明本發明之用以藥物傳遞之電解幫浦之裝置的一實施例示意圖。 [ Fig. 1 ] is a sectional view illustrating a schematic diagram of an embodiment of an electrolytic pump device for drug delivery according to the present invention.

[圖2A]為一剖面圖,說明本發明之部分的立體式電極對塗佈親水性材料的一實施例示意圖。 [ FIG. 2A ] is a cross-sectional view illustrating an embodiment of a part of the three-dimensional electrode pair coated with a hydrophilic material of the present invention.

[圖2B]為一立體外觀圖,說明本發明之部分的立體式電極對塗佈親水性材料的一實施例示意圖。 [ FIG. 2B ] is a three-dimensional appearance view, illustrating a schematic diagram of an embodiment of a part of the three-dimensional electrode pair coated with a hydrophilic material of the present invention.

[圖3A]為一立體外觀圖,說明本發明之立體式電極對的指狀流道的 壁上塗佈親水性材料的一實施例示意圖,且立體式電極對的一側為弧形。 [FIG. 3A] is a three-dimensional appearance diagram illustrating the structure of the finger-shaped flow channel of the three-dimensional electrode pair of the present invention. A schematic diagram of an embodiment of coating hydrophilic materials on the walls, and one side of the three-dimensional electrode pair is arc-shaped.

[圖3B]為一立體外觀圖,說明本發明之立體式電極對的指狀流道填充親水性材料的一實施例示意圖,且立體式電極對的一側為弧形。 [ FIG. 3B ] is a three-dimensional appearance diagram illustrating an embodiment of the finger-shaped flow channel of the three-dimensional electrode pair filled with hydrophilic material, and one side of the three-dimensional electrode pair is arc-shaped.

[圖4A]為一立體外觀圖,說明本發明之立體式電極對的指狀流道的壁上塗佈親水性材料的一實施例示意圖,且立體式電極對的一側為矩形。 [FIG. 4A] is a three-dimensional appearance diagram illustrating an embodiment of coating a hydrophilic material on the wall of the finger-shaped channel of the three-dimensional electrode pair of the present invention, and one side of the three-dimensional electrode pair is rectangular.

[圖4B]為一立體外觀圖,說明本發明之立體式電極對的指狀流道填充親水性材料的一實施例示意圖,且立體式電極對的一側為矩形。 [ FIG. 4B ] is a three-dimensional appearance view illustrating an embodiment of the finger-shaped flow channel of the three-dimensional electrode pair filled with hydrophilic material, and one side of the three-dimensional electrode pair is rectangular.

[圖5]為一方塊圖,說明本發明之一種用以藥物傳遞之電解幫浦之裝置的藥物傳遞方法。 [ Fig. 5 ] is a block diagram illustrating a drug delivery method of an electrolytic pump device for drug delivery according to the present invention.

為利 貴審查委員了解本發明之技術特徵、內容與優點及其所能達到之功效,茲將本發明配合圖式,並以實施例之表達形式詳細說明如下,而其中所使用之圖式,其主旨僅為示意及輔助說明書之用,未必為本發明實施後之真實比例與精準配置,故不應就所附之圖式的比例與配置關係解讀、侷限本發明於實際實施上的權利範圍,合先敘明。 In order for the Ligui Examiner to understand the technical features, content and advantages of the present invention and the effects it can achieve, the present invention is hereby combined with the drawings and described in detail in the form of embodiments as follows, and the drawings used therein, its The subject matter is only for illustration and auxiliary instructions, and not necessarily the true proportion and precise configuration of the present invention after implementation, so it should not be interpreted based on the proportion and configuration relationship of the attached drawings, and limit the scope of rights of the present invention in actual implementation. Together first describe.

請參見圖1,為本發明之一種用以藥物傳遞之電解幫浦之裝置100的剖面圖,說明該裝置包括一容置區110、一殼體120、一藥袋130、一電解幫浦單元140、一印刷電路板150以及一電源供應單元160,其中該容 置區110包括一第一腔室111、一第二腔室112及一第一隔膜113,該第一隔膜113位於該第一腔室111及該第二腔室之間112;該殼體120環繞且包覆該容置區110,且該殼體120為剛性材料且其表面塗佈生物相容性材料;該藥袋130用以容置實質上為液體的藥物;該電解幫浦單元140位於該第一腔室111且靠近該藥袋130設置,該電解幫浦單元140包括至少一立體式電極對141;該印刷電路板150位於該第二腔室112且電性連接該電解幫浦單元140;該電源供應單元160位於該第二腔室112且電性連接該印刷電路板150;該第一腔室111更包括一電源流路170,該電源流路170分別電性連接該電解幫浦單元140及該印刷電路板150;該殼體120開設一開口180,該開口180係以供一導管插設且該導管穿設入該藥袋130,其中該藥袋130中的藥物可自該容置區110經由該導管及該開口180而朝該殼體120外部釋放,或藥物可自該殼體120的外部經由該導管及該開口180而朝該藥袋130進行填充。 Please refer to FIG. 1 , which is a cross-sectional view of a device 100 of an electrolysis pump for drug delivery according to the present invention, illustrating that the device includes a holding area 110, a housing 120, a medicine bag 130, and an electrolysis pump unit. 140, a printed circuit board 150 and a power supply unit 160, wherein the container The placement area 110 includes a first chamber 111, a second chamber 112 and a first diaphragm 113, the first diaphragm 113 is located between the first chamber 111 and the second chamber 112; the housing 120 Surrounding and covering the accommodating area 110, the housing 120 is made of a rigid material and its surface is coated with a biocompatible material; the drug bag 130 is used to accommodate a drug that is substantially liquid; the electrolytic pump unit 140 Located in the first chamber 111 and disposed close to the medicine bag 130, the electrolysis pump unit 140 includes at least one three-dimensional electrode pair 141; the printed circuit board 150 is located in the second chamber 112 and electrically connected to the electrolysis pump unit 140; the power supply unit 160 is located in the second chamber 112 and is electrically connected to the printed circuit board 150; the first chamber 111 further includes a power flow path 170, and the power flow path 170 is electrically connected to the electrolytic The pump unit 140 and the printed circuit board 150; the casing 120 offers an opening 180, the opening 180 is used for inserting a catheter and the catheter is inserted into the medicine bag 130, wherein the medicine in the medicine bag 130 can be From the containing area 110 to the outside of the casing 120 through the conduit and the opening 180 , or the drug can be filled from the outside of the casing 120 to the medicine bag 130 through the conduit and the opening 180 .

請參閱圖2A及2B,圖2A為一剖面圖,說明本發明之部分的立體式電極對141塗佈親水性材料190的一實施例示意圖;圖2B為一立體外觀圖,說明本發明之部分的立體式電極對141塗佈親水性材料190的一實施例示意圖。 Please refer to FIGS. 2A and 2B. FIG. 2A is a cross-sectional view illustrating a schematic diagram of an embodiment of a three-dimensional electrode pair 141 coated with a hydrophilic material 190; FIG. 2B is a perspective view illustrating a part of the present invention A schematic diagram of an embodiment of the three-dimensional electrode pair 141 coated with a hydrophilic material 190 .

在一實施態樣中,該電解幫浦單元140具有複數立體式電極對141,該等立體式電極對141以串聯方式排列且該等立體式電極對141電性連接於該印刷電路板150。 In an embodiment, the electrolytic pump unit 140 has a plurality of three-dimensional electrode pairs 141 arranged in series and the three-dimensional electrode pairs 141 are electrically connected to the printed circuit board 150 .

請參閱圖3A至3B及圖4A至4B,該立體式電極對141具有一陰極板142及一陽極板143,其中該陰極板142具有複數陰極指狀結構144, 該陽極板143具有複數陽極指狀結構145;該等陰極指狀結構144及該等陽極指狀結構145交錯配置而構成一指叉型結構146,其中該等陰極指狀結構144及該等陽極指狀結構145之間具有一指狀流道147,該指狀流道147的其一開口148朝向該藥袋130(如圖1所示),較佳者該指狀流道147的其一開口正投影於該藥袋130,且該指狀流道147的其一開口連接該指狀流道147與容置於該第一腔室111的至少部分之電解液。 Please refer to FIGS. 3A to 3B and FIGS. 4A to 4B, the three-dimensional electrode pair 141 has a cathode plate 142 and an anode plate 143, wherein the cathode plate 142 has a plurality of cathode finger structures 144, The anode plate 143 has a plurality of anode finger structures 145; the cathode finger structures 144 and the anode finger structures 145 are staggered to form an interdigitated structure 146, wherein the cathode finger structures 144 and the anode There is a finger-shaped flow channel 147 between the finger-shaped structures 145, and an opening 148 of the finger-shaped flow channel 147 faces the medicine bag 130 (as shown in FIG. 1 ), preferably one of the finger-shaped flow channels 147 The opening is orthographically projected on the medicine bag 130 , and one opening of the finger channel 147 is connected to the finger channel 147 and at least part of the electrolyte contained in the first chamber 111 .

請再次參閱圖3A及3B,圖3A為一立體外觀圖,說明本發明之立體式電極對141的指狀流道147的壁上塗佈親水性材料190的一實施例示意圖,且立體式電極對141的一側為弧形310;圖3B為一立體外觀圖,說明本發明之立體式電極對141的指狀流道147填充親水性材料190的一實施例示意圖,且立體式電極對141的一側為弧形310。補充說明的是,該指狀流道147的壁上為,該等陰極指狀結構144及該等陽極指狀結構145的壁上。藉由弧形310結構設計,使得該立體電極對141產生的氣體易於脫離其表面且作動電解液,減少氣泡積聚於該立體電極對141的底部而影響該電解幫浦單元140在輔助藥物傳遞的效能;此外,該指狀流道147的壁上塗佈親水性材料190或該指狀流道147填充親水性材料190,有助於該立體電極對141產生的氣體移走且離開該指狀流道147。 Please refer to FIGS. 3A and 3B again. FIG. 3A is a three-dimensional appearance diagram illustrating a schematic diagram of an embodiment of coating a hydrophilic material 190 on the wall of the finger-shaped flow channel 147 of the three-dimensional electrode pair 141 of the present invention, and the three-dimensional electrode One side of the pair 141 is an arc 310; FIG. 3B is a three-dimensional appearance diagram illustrating a schematic diagram of an embodiment in which the finger-shaped flow channel 147 of the three-dimensional electrode pair 141 of the present invention is filled with a hydrophilic material 190, and the three-dimensional electrode pair 141 One side is arc 310. It is added that the walls of the finger channel 147 are on the walls of the cathode finger structures 144 and the anode finger structures 145 . The arc-shaped 310 structure design makes it easy for the gas generated by the three-dimensional electrode pair 141 to escape from its surface and activate the electrolyte, reducing the accumulation of air bubbles at the bottom of the three-dimensional electrode pair 141 and affecting the electrolytic pump unit 140 in assisting drug delivery. Effectiveness; In addition, coating the hydrophilic material 190 on the wall of the finger-shaped flow channel 147 or filling the hydrophilic material 190 in the finger-shaped flow channel 147 helps the gas generated by the three-dimensional electrode pair 141 to move away and leave the finger-shaped flow channel 147. Runner 147.

請再次參閱圖4A及4B,圖4A為一立體外觀圖,說明本發明之立體式電極對141的指狀流道147的壁上塗佈親水性材料190的一實施例示意圖,且立體式電極對141的一側為矩形320;圖4B為一立體外觀圖,說明本發明之立體式電極對141的指狀流道147填充親水性材料190的一實施 例示意圖,且立體式電極對141的一側為矩形320。 Please refer to FIGS. 4A and 4B again. FIG. 4A is a three-dimensional appearance diagram illustrating a schematic diagram of an embodiment of coating a hydrophilic material 190 on the wall of the finger-shaped flow channel 147 of the three-dimensional electrode pair 141 of the present invention, and the three-dimensional electrode One side of the pair 141 is a rectangle 320; FIG. 4B is a three-dimensional appearance view illustrating an implementation of filling the finger-shaped flow channel 147 of the three-dimensional electrode pair 141 of the present invention with a hydrophilic material 190 A schematic diagram of an example, and one side of the three-dimensional electrode pair 141 is a rectangle 320 .

請參閱圖5,圖5為一方塊圖,說明本發明之一種用以藥物傳遞之電解幫浦之裝置100的藥物傳遞方法,該方法包含下列步驟: Please refer to FIG. 5. FIG. 5 is a block diagram illustrating a drug delivery method of an electrolytic pump device 100 for drug delivery according to the present invention. The method includes the following steps:

(S510)提供一殼體120,該殼體120包覆一容置區110,該容置區110包括一第一腔室111、一第二腔室112及一第一隔膜113,該第一隔膜113位於該第一腔室111及該第二腔室112之間。 (S510) Provide a housing 120, the housing 120 covers a housing area 110, the housing area 110 includes a first chamber 111, a second chamber 112 and a first diaphragm 113, the first The diaphragm 113 is located between the first chamber 111 and the second chamber 112 .

(S520)設置一藥袋130及一靠近該藥袋130設置的電解幫浦單元140於該第一腔室111,其中該電解幫浦單元140包括至少一立體式電極對141,該立體式電極對141具有一陰極板142及一陽極板143,該陰極板142具有複數陰極指狀結構144,該陽極板143具有複數陽極指狀結構145,該等陰極指狀結構144及該等陽極指狀結構145交錯配置而構成一指叉型結構146,其中該等陰極指狀結構144及該等陽極指狀結構145之間具有一指狀流道147。 (S520) Set a medicine bag 130 and an electrolysis pump unit 140 disposed close to the medicine bag 130 in the first chamber 111, wherein the electrolysis pump unit 140 includes at least one three-dimensional electrode pair 141, the three-dimensional electrode Pair 141 has a cathode plate 142 and an anode plate 143, the cathode plate 142 has a plurality of cathode fingers 144, the anode plate 143 has a plurality of anode fingers 145, the cathode fingers 144 and the anode fingers The structures 145 are staggered to form an interdigitated structure 146 , wherein a finger channel 147 is provided between the cathode finger structures 144 and the anode finger structures 145 .

(S530)設置一印刷電路板150於該第二腔室112,該印刷電路板150電性連接該電解幫浦單元140。 ( S530 ) Install a printed circuit board 150 in the second chamber 112 , the printed circuit board 150 is electrically connected to the electrolytic pump unit 140 .

(S540)設置一電源供應單元160於該第二腔室112,該電源供應單元160電性連接該印刷電路板150,其中,在電化學反應,該立體式電極對141的任何一面係用以產生氣體,當該第一腔室111充填指定體積的電解液,且至少部分的氣體可經由該指狀流道147逸散於該第一腔室111,該立體式電極對141產生的氣體佔據了至少部分的電解液體積,藉此令至少部分的電解液及/或至少部分的氣體可壓縮該藥袋130。 (S540) Set a power supply unit 160 in the second chamber 112, the power supply unit 160 is electrically connected to the printed circuit board 150, wherein, in the electrochemical reaction, any side of the three-dimensional electrode pair 141 is used for Gas is generated. When the first chamber 111 is filled with a specified volume of electrolyte, and at least part of the gas can escape in the first chamber 111 through the finger channel 147, the gas generated by the three-dimensional electrode pair 141 occupies At least part of the volume of the electrolyte solution is increased, thereby allowing at least part of the electrolyte solution and/or at least part of the gas to compress the pouch 130 .

惟以上所述者,僅為本發明之較佳實施例而已,當不能以此 限定本發明實施之範圍,即大凡依本發明申請專利範圍及發明說明內容所作之簡單的等效變化與修飾,皆仍屬本發明專利涵蓋之範圍內。 But what is described above is only a preferred embodiment of the present invention, and should not be used in this way. The implementation scope of the present invention is limited, that is, all simple equivalent changes and modifications made according to the patent scope of the present invention and the description of the invention are still within the scope covered by the patent of the present invention.

100:用以藥物傳遞之電解幫浦之裝置 100: Electrolysis pump device for drug delivery

110:容置區 110: Containment area

111:第一腔室 111: The first chamber

112:第二腔室 112: second chamber

113:第一隔膜 113: First diaphragm

120:殼體 120: shell

130:藥袋 130: medicine bag

140:電解幫浦單元 140: Electrolytic pump unit

141:立體式電極對 141: three-dimensional electrode pair

146:指叉型結構 146: Interdigitated structure

148:指狀流道的其一開口 148: One of the openings of the finger channel

150:印刷電路板 150: printed circuit board

160:電源供應單元 160: Power supply unit

170:電源流路 170: Power flow path

180:開口 180: opening

Claims (12)

一種用以藥物傳遞之電解幫浦之裝置,該裝置包括: An electrolytic pump device for drug delivery, the device comprising: 一容置區,其包括一第一腔室、一第二腔室及一第一隔膜,該第一隔膜位於該第一腔室及該第二腔室之間; A containing area, which includes a first chamber, a second chamber and a first diaphragm, the first diaphragm is located between the first chamber and the second chamber; 一殼體,該殼體環繞且包覆該容置區; a casing, the casing surrounds and covers the accommodating area; 一位於該第一腔室的藥袋; a medicine bag located in the first chamber; 一位於該第一腔室且靠近該藥袋設置的電解幫浦單元,其包括至少一立體式電極對,該立體式電極對具有一陰極板及一陽極板,其中該陰極板具有複數陰極指狀結構,該陽極板具有複數陽極指狀結構,該等陰極指狀結構及該等陽極指狀結構交錯配置而構成一指叉型結構,其中該等陰極指狀結構及該等陽極指狀結構之間具有一指狀流道; An electrolytic pump unit located in the first chamber and disposed close to the medicine bag, which includes at least one three-dimensional electrode pair, the three-dimensional electrode pair has a cathode plate and an anode plate, wherein the cathode plate has a plurality of cathode fingers The anode plate has a plurality of anode finger structures, the cathode finger structures and the anode finger structures are interlaced to form an interdigitated structure, wherein the cathode finger structures and the anode finger structures There is a finger-like flow channel between them; 一位於該第二腔室的印刷電路板,該印刷電路板電性連接該電解幫浦單元;及 a printed circuit board located in the second chamber, the printed circuit board electrically connected to the electrolysis pump unit; and 一位於該第二腔室的電源供應單元,該電源供應單元電性連接該印刷電路板; a power supply unit located in the second chamber, the power supply unit electrically connected to the printed circuit board; 其中,該立體式電極對的任一面係用以在電化學反應產生氣體,且至少部分的氣體可經由該指狀流道逸散於該第一腔室。 Wherein, any surface of the three-dimensional electrode pair is used to generate gas during electrochemical reaction, and at least part of the gas can escape into the first chamber through the finger-shaped channel. 一種用以藥物傳遞之電解幫浦之裝置,該裝置包括: An electrolytic pump device for drug delivery, the device comprising: 一容置區,其包括一第一腔室、一第二腔室、一第一隔膜及一軟性第二隔膜,其中,該第一隔膜位於該第一腔室及該第二腔室之間,該軟性第二隔膜位於該第一腔室; A containment area comprising a first chamber, a second chamber, a first diaphragm and a flexible second diaphragm, wherein the first diaphragm is located between the first chamber and the second chamber , the flexible second diaphragm is located in the first chamber; 一殼體,該殼體環繞且包覆該容置區,其中,部分之殼體與該軟性第二 隔膜圍繞以形成一第二隔膜區,該第二隔膜區係用以容置藥物; A casing, the casing surrounds and covers the accommodating area, wherein part of the casing and the soft second The diaphragm surrounds to form a second diaphragm area, and the second diaphragm area is used to accommodate medicine; 一位於該第一腔室且靠近該第二隔膜區設置的電解幫浦單元,其包括至少一立體式電極對,該立體式電極對具有一陰極板及一陽極板,其中該陰極板具有複數陰極指狀結構,該陽極板具有複數陽極指狀結構,該等陰極指狀結構及該等陽極指狀結構交錯配置而構成一指叉型結構,其中該等陰極指狀結構及該等陽極指狀結構之間具有一指狀流道; An electrolytic pump unit located in the first chamber and disposed close to the second diaphragm region, which includes at least one three-dimensional electrode pair, the three-dimensional electrode pair has a cathode plate and an anode plate, wherein the cathode plate has a plurality of Cathode finger structure, the anode plate has a plurality of anode finger structures, the cathode finger structures and the anode finger structures are interlaced to form an interdigitated structure, wherein the cathode finger structures and the anode finger structures There is a finger-like channel between the structures; 一位於該第二腔室的印刷電路板,該印刷電路板電性連接該電解幫浦單元;及 a printed circuit board located in the second chamber, the printed circuit board electrically connected to the electrolysis pump unit; and 一位於該第二腔室的電源供應單元,該電源供應單元電性連接該印刷電路板; a power supply unit located in the second chamber, the power supply unit electrically connected to the printed circuit board; 其中,該立體式電極對的任一面係用以在電化學反應產生氣體,且至少部分的氣體可經由該指狀流道逸散於該第一腔室。 Wherein, any surface of the three-dimensional electrode pair is used to generate gas during electrochemical reaction, and at least part of the gas can escape into the first chamber through the finger-shaped channel. 如請求項1之裝置,其中該指狀流道的其一開口正投影於該藥袋。 The device according to claim 1, wherein one opening of the finger-shaped flow channel is orthographically projected on the medicine bag. 如請求項1或2之裝置,其中該指狀流道填充有孔隙的親水性材料。 The device according to claim 1 or 2, wherein the finger-shaped channel is filled with porous hydrophilic material. 如請求項1之裝置,其中該立體式電極對遠離該藥袋的一側的構型包括弧形、矩形或尖角形。 The device according to claim 1, wherein the configuration of the side of the three-dimensional electrode pair away from the medicine bag includes arc, rectangle or pointed shape. 如請求項1或2之裝置,其中該陰極板及該陽極板表面分別塗佈親水性材料。 The device according to claim 1 or 2, wherein the surfaces of the cathode plate and the anode plate are respectively coated with hydrophilic materials. 如請求項1或2之裝置,其中該電解幫浦單元具有複數立體式 電極對,該等立體式電極對以串聯方式排列且該等立體式電極對電性連接於該印刷電路板。 The device as claimed in claim 1 or 2, wherein the electrolytic pump unit has a plurality of three-dimensional Electrode pairs, the three-dimensional electrode pairs are arranged in series and the three-dimensional electrode pairs are electrically connected to the printed circuit board. 如請求項1或2之裝置,其中該第一腔室更包括一電源流路,該電源流路分別電性連接該電解幫浦單元及該印刷電路板。 The device according to claim 1 or 2, wherein the first chamber further includes a power flow path, and the power flow path is electrically connected to the electrolysis pump unit and the printed circuit board respectively. 如請求項1之裝置,其中該殼體開設一開口,該開口係以供一導管插設且該導管穿設入該藥袋。 The device according to claim 1, wherein the casing defines an opening for inserting a catheter and the catheter is inserted into the medicine bag. 如請求項1或2之裝置,該殼體的材料可為剛性材料、柔性材料、或剛性材料與柔性材料的複合材料,且該殼體的表面塗佈生物相容性材料。 As in the device of claim 1 or 2, the material of the shell can be rigid material, flexible material, or a composite material of rigid material and flexible material, and the surface of the shell is coated with biocompatible material. 一種以請求項1之用以藥物傳遞之電解幫浦之裝置的藥物傳遞方法,該方法包括下列步驟: A drug delivery method using the electrolysis pump device for drug delivery in claim 1, the method includes the following steps: 將一藥袋及一電解幫浦單元相鄰設置於一殼體內之一第一腔室中,其中該殼體內更包含一相鄰於該第一腔室之第二腔室,其中該電解幫浦單元包括至少一立體式電極對,該立體式電極對具有一陰極板及一陽極板,該陰極板具有複數陰極指狀結構,該陽極板具有複數陽極指狀結構,該等陰極指狀結構及該等陽極指狀結構交錯配置而構成一指叉型結構,其中該等陰極指狀結構及該等陽極指狀結構之間具有一指狀流道; A medicine bag and an electrolytic pump unit are adjacently arranged in a first chamber in a casing, wherein the casing further includes a second chamber adjacent to the first chamber, wherein the electrolytic pump unit The pump unit includes at least one three-dimensional electrode pair, the three-dimensional electrode pair has a cathode plate and an anode plate, the cathode plate has a plurality of cathode finger structures, the anode plate has a plurality of anode finger structures, and the cathode finger structures and the anode finger structures are staggered to form an interdigitated structure, wherein there is a finger flow channel between the cathode finger structures and the anode finger structures; 將一第一隔膜設置於該第一腔室及該第二腔室之間; disposing a first diaphragm between the first chamber and the second chamber; 將一印刷電路板及一電源供應單元設置於該殼體內的第二腔室中,且該電源供應單元電性連接該印刷電路板;及 disposing a printed circuit board and a power supply unit in the second chamber in the housing, and the power supply unit is electrically connected to the printed circuit board; and 將該印刷電路板電性連接該電解幫浦單元; electrically connecting the printed circuit board to the electrolytic pump unit; 其中,在電化學反應,該立體式電極對的任何一面係用以產生氣體,當該第一腔室充填指定體積的電解液,且至少部分的氣體可經由該指狀流道逸散於該第一腔室,該立體式電極對產生的氣體佔據了至少部分的電解液體積,藉此令至少部分的電解液及/或至少部分的氣體可壓縮藥袋。 Wherein, in the electrochemical reaction, any side of the three-dimensional electrode pair is used to generate gas. When the first chamber is filled with a specified volume of electrolyte, at least part of the gas can escape to the In the first chamber, the gas generated by the three-dimensional electrode pair occupies at least part of the volume of the electrolyte, so that at least part of the electrolyte and/or at least part of the gas can compress the medicine bag. 一種以請求項2之用以藥物傳遞之電解幫浦之裝置的藥物傳遞方法,該方法包括下列步驟: A drug delivery method using the electrolytic pump device for drug delivery according to claim 2, the method includes the following steps: 將一第二隔膜區及一電解幫浦單元相鄰設置於一殼體內之一第一腔室中,其中該殼體內更包含一相鄰於該第一腔室之第二腔室,其中該電解幫浦單元包括至少一立體式電極對,該立體式電極對具有一陰極板及一陽極板,該陰極板具有複數陰極指狀結構,該陽極板具有複數陽極指狀結構,該等陰極指狀結構及該等陽極指狀結構交錯配置而構成一指叉型結構,其中該等陰極指狀結構及該等陽極指狀結構之間具有一指狀流道; A second diaphragm area and an electrolytic pump unit are adjacently disposed in a first chamber in a casing, wherein the casing further includes a second chamber adjacent to the first chamber, wherein the The electrolytic pump unit includes at least one three-dimensional electrode pair, the three-dimensional electrode pair has a cathode plate and an anode plate, the cathode plate has a plurality of cathode finger structures, the anode plate has a plurality of anode finger structures, and the cathode fingers The interdigitated structures and the anode finger structures are interlaced to form an interdigitated structure, wherein there is a finger flow channel between the cathode finger structures and the anode finger structures; 將一第一隔膜設置於該第一腔室及該第二腔室之間; disposing a first diaphragm between the first chamber and the second chamber; 將一印刷電路板及一電源供應單元設置於該殼體內的第二腔室中,且該電源供應單元電性連接該印刷電路板;及 disposing a printed circuit board and a power supply unit in the second chamber in the housing, and the power supply unit is electrically connected to the printed circuit board; and 將該印刷電路板電性連接該電解幫浦單元; electrically connecting the printed circuit board to the electrolytic pump unit; 其中,在電化學反應,該立體式電極對的任何一面係用以產生氣體,當該第一腔室充填指定體積的電解液,且至少部分的氣體可經由該指狀流道逸散於該第一腔室,該立體式電極對產生的氣體佔據了至少部分的電解液體積,藉此令至少部分的電解液及/或至少部分的氣體可壓縮該第二隔膜區。 Wherein, in the electrochemical reaction, any side of the three-dimensional electrode pair is used to generate gas. When the first chamber is filled with a specified volume of electrolyte, at least part of the gas can escape to the In the first chamber, the gas generated by the three-dimensional electrode pair occupies at least part of the volume of the electrolyte, so that at least part of the electrolyte and/or at least part of the gas can compress the second membrane region.
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