TW202242896A - Electrolytic pump device and method for drug delivery solve the problem that the gas is generated in one direction and accumulates on the bottom of the electrode body - Google Patents

Abstract

The present invention provides an electrolytic pump device for drug delivery, which includes: an accommodating area, a casing, a medicine bag, an electrolytic pump unit, a printed circuit board, and a power supply unit. The advantageous effect is that, by the improvement of the three-dimensional structure of the electrolytic pump unit, the electrolytic pump unit can generate a gas more efficiently and solve the problem that the gas is generated in one direction and accumulates on the bottom of the electrode body.

Description

Device and method for electrolysis pump for drug delivery

The invention belongs to a device and method of an electrolytic pump for drug delivery, in particular to the improvement of components and functions to enhance the performance of the gas generated by the electrolytic pump for drug delivery.

Common routes of administration include ear, eye, nose, oral, rectal, aerosol, gastrointestinal, intravenous administration, lung, mucosal penetration, skin penetration and topical administration, and for cancer, chronic disease or cardiovascular disease For hypertensive patients, it is easy to face the need for long-term, regular and specified doses of medication, and it is also easy to encounter life-threatening situations due to forgetting to take medication. In order to benefit the general public, under the rapid improvement of medical technology, an implantable drug delivery system has been developed to save patients from the life-threatening risks of repeated injections or forgetting to take medicine.

In the technical field of implantable drug delivery systems, it is common to use planar electrodes through semiconductor processes to generate gas to achieve the function of drug delivery. However, planar electrodes through semiconductor processes have the following technical defects. First, planar electrodes The generated gas has a directional problem, and due to the structure of the planar electrode, the gas generated by the electrode tends to accumulate at the bottom of the planar electrode, thereby reducing the performance of the electrochemical reaction and drug delivery. The planar electrodes of the process are expensive to manufacture.

The above-mentioned disadvantages show various problems arising from the conventional planar electrodes in the process of carrying out electrochemical reactions for drug delivery. Therefore, how to solve the problem of the directionality of the gas generated by the electrode used for drug delivery and how to prolong the power supply life of the electrode used for drug delivery, so as to improve the gas generation of the electrochemical reaction of the electrode and the efficiency of drug delivery, are The issues that all parties are facing and attaching great importance to, therefore, the existing technology really needs to propose a better solution.

Based on the technical deficiencies in the prior art, the object of the present invention is to provide an electrolytic pump device and method for drug delivery, so as to improve and enhance the performance of gas generation and drug delivery in the electrochemical reaction of electrodes.

First of all, the main purpose of the present invention is to provide an electrolytic pump device for drug delivery, which device includes: an accommodating area, a casing, a medicine bag, an electrolytic pump unit, a printed circuit board and a Power supply unit.

Wherein, the accommodating area includes a first chamber, a second chamber and a first diaphragm, and the first diaphragm is located between the first chamber and the second chamber.

Wherein, the casing surrounds and covers the accommodating area, and the material of the casing can be rigid material, flexible material, or composite material of rigid material and flexible material.

Wherein, the medicine bag is used for accommodating medicine which is substantially liquid.

Wherein, the electrolytic pump unit is located in the first chamber and is set close to the medicine bag, The electrolytic pump unit includes at least one three-dimensional electrode pair, the three-dimensional electrode pair has a cathode plate and an anode plate, wherein the cathode plate has a plurality of cathode finger structures, and the anode plate has a plurality of anode finger structures; The cathode finger structures and the anode finger structures are interlaced to form an interdigitated structure, wherein there is a finger flow channel between the cathode finger structures and the anode finger structures. In detail, the three-dimensional electrode pair of the present invention, due to the advantages of its three-dimensional structure, increases the contact area of the three-dimensional electrode for the electrochemical reaction, and any surface of the three-dimensional electrode pair can be used in the electrochemical reaction. Gas generation solves the defect that the conventional planar electrodes can only generate gas in a single direction. In addition, the three-dimensional electrode pair with an interdigitated structure can reduce the required accommodation space of the three-dimensional electrode pair.

Wherein, the printed circuit board is located in the second chamber and is electrically connected to the electrolytic pump unit.

Wherein, the power supply unit is located in the second chamber and electrically connected to the printed circuit board.

Further, one opening of the finger-shaped flow channel faces the medicine bag, preferably one opening of the finger-shaped flow channel is orthographically projected on the medicine bag, and one opening of the finger-shaped flow channel is connected to the finger-shaped flow channel. The flow channel and at least part of the electrolyte contained in the first chamber. With such a structure and design of relative positions, the finger-shaped flow channel can provide at least part of the gas generated by the three-dimensional electrode pair to escape into the first chamber through the finger-shaped flow channel. Therefore, the structural design of the finger-shaped flow channel is conducive to the removal of the gas generated by the three-dimensional electrode pair, and one opening of the finger-shaped flow channel faces the medicine bag, which can help the removed gas to actuate the gas adjacent to the medicine bag. Electrolyte, which in turn compresses the pouch for drug delivery.

Further, the finger channel is filled with porous hydrophilic material, which contributes to the The gas generated by the three-dimensional electrode pair escapes from its surface.

Further, the configuration of the side of the three-dimensional electrode pair away from the medicine bag includes arc, rectangle or pointed shape. With the aforementioned technical features, the gas generated by the three-dimensional electrode pair is easy to escape from its surface and activate the electrolyte, reducing the accumulation of bubbles at the bottom of the three-dimensional electrode pair and affecting the performance of the electrolytic pump in assisting drug delivery.

Further, the surfaces of the cathode plate and the anode plate are respectively coated with hydrophilic materials to promote the detachment of air bubbles from the surfaces of the cathode plate and the anode plate.

Further, the electrolytic pump unit has a plurality of three-dimensional electrode pairs, the three-dimensional electrode pairs are arranged in series, and the three-dimensional electrode pairs are electrically connected to the printed circuit board.

Further, the first chamber further includes a power flow path, and the power flow path is electrically connected to the electrolytic pump unit and the printed circuit board respectively.

Further, the casing defines an opening for inserting a catheter and passing the catheter into the medicine bag, wherein the medicine in the medicine bag can pass through the catheter and the opening from the containing area toward the The housing is externally released, or drug can be filled towards the pouch from the outside of the housing through the conduit and the opening.

Further, the housing is provided with two openings, the two openings are used for inserting the catheter and passing the catheter into the medicine bag, wherein the medicine in the medicine bag can flow from the containing area through a catheter and an opening to the The housing is externally released and, furthermore, drug can be filled towards the pouch from the outside of the housing via another conduit and another opening.

Further, the material of the shell is rigid material, flexible material or rigid material Composite material with flexible material, and the shell surface is coated with biocompatible material.

In addition, the present invention provides another electrolytic pump device for drug delivery, which uses a second diaphragm area to replace the drug containing function of the aforementioned drug bag. Specifically, the accommodating area further includes a second diaphragm, the second diaphragm is located in the first chamber, and part of the housing is surrounded by the second diaphragm to form the second diaphragm area, and the The material of the second diaphragm can be soft material.

In addition, another object of the present invention is to provide a drug delivery method for an electrolysis pump device for drug delivery, the method comprising the following steps: combining a drug bag and/or the second diaphragm area with an electrolysis pump unit Adjacently disposed in a first chamber in a housing, wherein the housing further includes a second chamber adjacent to the first chamber, wherein the electrolytic pump unit includes at least one three-dimensional electrode pair, the The three-dimensional electrode pair has a cathode plate and an anode plate, the cathode plate has a plurality of cathode finger structures, the anode plate has a plurality of anode finger structures, and the cathode finger structures and the anode finger structures are staggered to form a structure An interdigitated structure, wherein there is a finger-shaped flow channel between the cathode finger structures and the anode finger structures; a first diaphragm is arranged between the first chamber and the second chamber; a printed circuit board and a power supply unit are arranged in the second chamber in the casing, and the power supply unit is electrically connected to the printed circuit board; and the printed circuit board is electrically connected to the electrolysis pump unit; Wherein, in the electrochemical reaction, any side of the three-dimensional electrode pair is used to generate gas. When the first chamber is filled with a specified volume of electrolyte, at least part of the gas can escape to the In the first chamber, the gas generated by the three-dimensional electrode pair occupies at least part of the volume of the electrolyte, so that at least part of the electrolyte and/or at least part of the gas can compress the medicine bag and/or the second membrane region.

Overall, the beneficial effects of the present invention at least include:

1. By improving the structure of the three-dimensional electrode pair, the performance of the electrolytic pump to generate gas is improved. At the same time, the finger-like structure of the three-dimensional electrode pair is used to provide a finger-like flow channel, which is beneficial for the gas to move away from the electrode surface and move adjacent to the electrode. The electrolyte of the pouch, which is compressed for drug delivery.

2. With the improvement of the structure of the three-dimensional electrode pair, the consumed electric energy can be efficiently converted into the generated gas, which helps to reduce the required electric energy for the electrolysis pump to generate the gas, and improves the endurance of the drug delivery system in use.

3. The configuration of the side of the three-dimensional electrode pair far away from the medicine bag includes the technical features of arc, rectangle or sharp angle, so that the gas generated by the three-dimensional electrode pair is easy to break away from its surface and activate the electrolyte, reducing air bubbles Accumulation at the bottom of the three-dimensional electrode pair affects the efficiency of the electrolytic pump in assisting drug delivery.

100: Electrolysis pump device for drug delivery

110: Containment area

111: The first chamber

112: second chamber

113: First diaphragm

120: shell

130: medicine bag

140: Electrolytic pump unit

141: three-dimensional electrode pair

142: cathode plate

143: anode plate

144: cathode finger structure

145: Anode finger structure

146: Interdigitated structure

147: finger flow channel

148: One of the openings of the finger channel

150: printed circuit board

160: Power supply unit

170: Power flow path

180: opening

190: Hydrophilic material

210: electrode connector

310: Arc

320: rectangle

S510~S540: steps

[ Fig. 1 ] is a sectional view illustrating a schematic diagram of an embodiment of an electrolytic pump device for drug delivery according to the present invention.

[ FIG. 2A ] is a cross-sectional view illustrating an embodiment of a part of the three-dimensional electrode pair coated with a hydrophilic material of the present invention.

[ FIG. 2B ] is a three-dimensional appearance view, illustrating a schematic diagram of an embodiment of a part of the three-dimensional electrode pair coated with a hydrophilic material of the present invention.

[FIG. 3A] is a three-dimensional appearance diagram illustrating the structure of the finger-shaped flow channel of the three-dimensional electrode pair of the present invention. A schematic diagram of an embodiment of coating hydrophilic materials on the walls, and one side of the three-dimensional electrode pair is arc-shaped.

[ FIG. 3B ] is a three-dimensional appearance diagram illustrating an embodiment of the finger-shaped flow channel of the three-dimensional electrode pair filled with hydrophilic material, and one side of the three-dimensional electrode pair is arc-shaped.

[FIG. 4A] is a three-dimensional appearance diagram illustrating an embodiment of coating a hydrophilic material on the wall of the finger-shaped channel of the three-dimensional electrode pair of the present invention, and one side of the three-dimensional electrode pair is rectangular.

[ FIG. 4B ] is a three-dimensional appearance view illustrating an embodiment of the finger-shaped flow channel of the three-dimensional electrode pair filled with hydrophilic material, and one side of the three-dimensional electrode pair is rectangular.

[ Fig. 5 ] is a block diagram illustrating a drug delivery method of an electrolytic pump device for drug delivery according to the present invention.

In order for the Ligui Examiner to understand the technical features, content and advantages of the present invention and the effects it can achieve, the present invention is hereby combined with the drawings and described in detail in the form of embodiments as follows, and the drawings used therein, its The subject matter is only for illustration and auxiliary instructions, and not necessarily the true proportion and precise configuration of the present invention after implementation, so it should not be interpreted based on the proportion and configuration relationship of the attached drawings, and limit the scope of rights of the present invention in actual implementation. Together first describe.

Please refer to FIG. 1 , which is a cross-sectional view of a device 100 of an electrolysis pump for drug delivery according to the present invention, illustrating that the device includes a holding area 110, a housing 120, a medicine bag 130, and an electrolysis pump unit. 140, a printed circuit board 150 and a power supply unit 160, wherein the container The placement area 110 includes a first chamber 111, a second chamber 112 and a first diaphragm 113, the first diaphragm 113 is located between the first chamber 111 and the second chamber 112; the housing 120 Surrounding and covering the accommodating area 110, the housing 120 is made of a rigid material and its surface is coated with a biocompatible material; the drug bag 130 is used to accommodate a drug that is substantially liquid; the electrolytic pump unit 140 Located in the first chamber 111 and disposed close to the medicine bag 130, the electrolysis pump unit 140 includes at least one three-dimensional electrode pair 141; the printed circuit board 150 is located in the second chamber 112 and electrically connected to the electrolysis pump unit 140; the power supply unit 160 is located in the second chamber 112 and is electrically connected to the printed circuit board 150; the first chamber 111 further includes a power flow path 170, and the power flow path 170 is electrically connected to the electrolytic The pump unit 140 and the printed circuit board 150; the casing 120 offers an opening 180, the opening 180 is used for inserting a catheter and the catheter is inserted into the medicine bag 130, wherein the medicine in the medicine bag 130 can be From the containing area 110 to the outside of the casing 120 through the conduit and the opening 180 , or the drug can be filled from the outside of the casing 120 to the medicine bag 130 through the conduit and the opening 180 .

Please refer to FIGS. 2A and 2B. FIG. 2A is a cross-sectional view illustrating a schematic diagram of an embodiment of a three-dimensional electrode pair 141 coated with a hydrophilic material 190; FIG. 2B is a perspective view illustrating a part of the present invention A schematic diagram of an embodiment of the three-dimensional electrode pair 141 coated with a hydrophilic material 190 .

In an embodiment, the electrolytic pump unit 140 has a plurality of three-dimensional electrode pairs 141 arranged in series and the three-dimensional electrode pairs 141 are electrically connected to the printed circuit board 150 .

Please refer to FIGS. 3A to 3B and FIGS. 4A to 4B, the three-dimensional electrode pair 141 has a cathode plate 142 and an anode plate 143, wherein the cathode plate 142 has a plurality of cathode finger structures 144, The anode plate 143 has a plurality of anode finger structures 145; the cathode finger structures 144 and the anode finger structures 145 are staggered to form an interdigitated structure 146, wherein the cathode finger structures 144 and the anode There is a finger-shaped flow channel 147 between the finger-shaped structures 145, and an opening 148 of the finger-shaped flow channel 147 faces the medicine bag 130 (as shown in FIG. 1 ), preferably one of the finger-shaped flow channels 147 The opening is orthographically projected on the medicine bag 130 , and one opening of the finger channel 147 is connected to the finger channel 147 and at least part of the electrolyte contained in the first chamber 111 .

Please refer to FIGS. 3A and 3B again. FIG. 3A is a three-dimensional appearance diagram illustrating a schematic diagram of an embodiment of coating a hydrophilic material 190 on the wall of the finger-shaped flow channel 147 of the three-dimensional electrode pair 141 of the present invention, and the three-dimensional electrode One side of the pair 141 is an arc 310; FIG. 3B is a three-dimensional appearance diagram illustrating a schematic diagram of an embodiment in which the finger-shaped flow channel 147 of the three-dimensional electrode pair 141 of the present invention is filled with a hydrophilic material 190, and the three-dimensional electrode pair 141 One side is arc 310. It is added that the walls of the finger channel 147 are on the walls of the cathode finger structures 144 and the anode finger structures 145 . The arc-shaped 310 structure design makes it easy for the gas generated by the three-dimensional electrode pair 141 to escape from its surface and activate the electrolyte, reducing the accumulation of air bubbles at the bottom of the three-dimensional electrode pair 141 and affecting the electrolytic pump unit 140 in assisting drug delivery. Effectiveness; In addition, coating the hydrophilic material 190 on the wall of the finger-shaped flow channel 147 or filling the hydrophilic material 190 in the finger-shaped flow channel 147 helps the gas generated by the three-dimensional electrode pair 141 to move away and leave the finger-shaped flow channel 147. Runner 147.

Please refer to FIGS. 4A and 4B again. FIG. 4A is a three-dimensional appearance diagram illustrating a schematic diagram of an embodiment of coating a hydrophilic material 190 on the wall of the finger-shaped flow channel 147 of the three-dimensional electrode pair 141 of the present invention, and the three-dimensional electrode One side of the pair 141 is a rectangle 320; FIG. 4B is a three-dimensional appearance view illustrating an implementation of filling the finger-shaped flow channel 147 of the three-dimensional electrode pair 141 of the present invention with a hydrophilic material 190 A schematic diagram of an example, and one side of the three-dimensional electrode pair 141 is a rectangle 320 .

Please refer to FIG. 5. FIG. 5 is a block diagram illustrating a drug delivery method of an electrolytic pump device 100 for drug delivery according to the present invention. The method includes the following steps:

(S510) Provide a housing 120, the housing 120 covers a housing area 110, the housing area 110 includes a first chamber 111, a second chamber 112 and a first diaphragm 113, the first The diaphragm 113 is located between the first chamber 111 and the second chamber 112 .

(S520) Set a medicine bag 130 and an electrolysis pump unit 140 disposed close to the medicine bag 130 in the first chamber 111, wherein the electrolysis pump unit 140 includes at least one three-dimensional electrode pair 141, the three-dimensional electrode Pair 141 has a cathode plate 142 and an anode plate 143, the cathode plate 142 has a plurality of cathode fingers 144, the anode plate 143 has a plurality of anode fingers 145, the cathode fingers 144 and the anode fingers The structures 145 are staggered to form an interdigitated structure 146 , wherein a finger channel 147 is provided between the cathode finger structures 144 and the anode finger structures 145 .

( S530 ) Install a printed circuit board 150 in the second chamber 112 , the printed circuit board 150 is electrically connected to the electrolytic pump unit 140 .

(S540) Set a power supply unit 160 in the second chamber 112, the power supply unit 160 is electrically connected to the printed circuit board 150, wherein, in the electrochemical reaction, any side of the three-dimensional electrode pair 141 is used for Gas is generated. When the first chamber 111 is filled with a specified volume of electrolyte, and at least part of the gas can escape in the first chamber 111 through the finger channel 147, the gas generated by the three-dimensional electrode pair 141 occupies At least part of the volume of the electrolyte solution is increased, thereby allowing at least part of the electrolyte solution and/or at least part of the gas to compress the pouch 130 .

But what is described above is only a preferred embodiment of the present invention, and should not be used in this way. The implementation scope of the present invention is limited, that is, all simple equivalent changes and modifications made according to the patent scope of the present invention and the description of the invention are still within the scope covered by the patent of the present invention.

100: Electrolysis pump device for drug delivery

110: Containment area

111: The first chamber

112: second chamber

113: First diaphragm

120: shell

130: medicine bag

140: Electrolytic pump unit

141: three-dimensional electrode pair

146: Interdigitated structure

148: One of the openings of the finger channel

150: printed circuit board

160: Power supply unit

170: Power flow path

180: opening

Claims (12)

An electrolytic pump device for drug delivery, the device comprising: A containing area, which includes a first chamber, a second chamber and a first diaphragm, the first diaphragm is located between the first chamber and the second chamber; a casing, the casing surrounds and covers the accommodating area; a medicine bag located in the first chamber; An electrolytic pump unit located in the first chamber and disposed close to the medicine bag, which includes at least one three-dimensional electrode pair, the three-dimensional electrode pair has a cathode plate and an anode plate, wherein the cathode plate has a plurality of cathode fingers The anode plate has a plurality of anode finger structures, the cathode finger structures and the anode finger structures are interlaced to form an interdigitated structure, wherein the cathode finger structures and the anode finger structures There is a finger-like flow channel between them; a printed circuit board located in the second chamber, the printed circuit board electrically connected to the electrolysis pump unit; and a power supply unit located in the second chamber, the power supply unit electrically connected to the printed circuit board; Wherein, any surface of the three-dimensional electrode pair is used to generate gas during electrochemical reaction, and at least part of the gas can escape into the first chamber through the finger-shaped channel. An electrolytic pump device for drug delivery, the device comprising: A containment area comprising a first chamber, a second chamber, a first diaphragm and a flexible second diaphragm, wherein the first diaphragm is located between the first chamber and the second chamber , the flexible second diaphragm is located in the first chamber; A casing, the casing surrounds and covers the accommodating area, wherein part of the casing and the soft second The diaphragm surrounds to form a second diaphragm area, and the second diaphragm area is used to accommodate medicine; An electrolytic pump unit located in the first chamber and disposed close to the second diaphragm region, which includes at least one three-dimensional electrode pair, the three-dimensional electrode pair has a cathode plate and an anode plate, wherein the cathode plate has a plurality of Cathode finger structure, the anode plate has a plurality of anode finger structures, the cathode finger structures and the anode finger structures are interlaced to form an interdigitated structure, wherein the cathode finger structures and the anode finger structures There is a finger-like channel between the structures; a printed circuit board located in the second chamber, the printed circuit board electrically connected to the electrolysis pump unit; and a power supply unit located in the second chamber, the power supply unit electrically connected to the printed circuit board; Wherein, any surface of the three-dimensional electrode pair is used to generate gas during electrochemical reaction, and at least part of the gas can escape into the first chamber through the finger-shaped channel. The device according to claim 1, wherein one opening of the finger-shaped flow channel is orthographically projected on the medicine bag. The device according to claim 1 or 2, wherein the finger-shaped channel is filled with porous hydrophilic material. The device according to claim 1, wherein the configuration of the side of the three-dimensional electrode pair away from the medicine bag includes arc, rectangle or pointed shape. The device according to claim 1 or 2, wherein the surfaces of the cathode plate and the anode plate are respectively coated with hydrophilic materials. The device as claimed in claim 1 or 2, wherein the electrolytic pump unit has a plurality of three-dimensional Electrode pairs, the three-dimensional electrode pairs are arranged in series and the three-dimensional electrode pairs are electrically connected to the printed circuit board. The device according to claim 1 or 2, wherein the first chamber further includes a power flow path, and the power flow path is electrically connected to the electrolysis pump unit and the printed circuit board respectively. The device according to claim 1, wherein the casing defines an opening for inserting a catheter and the catheter is inserted into the medicine bag. As in the device of claim 1 or 2, the material of the shell can be rigid material, flexible material, or a composite material of rigid material and flexible material, and the surface of the shell is coated with biocompatible material. A drug delivery method using the electrolysis pump device for drug delivery in claim 1, the method includes the following steps: A medicine bag and an electrolytic pump unit are adjacently arranged in a first chamber in a casing, wherein the casing further includes a second chamber adjacent to the first chamber, wherein the electrolytic pump unit The pump unit includes at least one three-dimensional electrode pair, the three-dimensional electrode pair has a cathode plate and an anode plate, the cathode plate has a plurality of cathode finger structures, the anode plate has a plurality of anode finger structures, and the cathode finger structures and the anode finger structures are staggered to form an interdigitated structure, wherein there is a finger flow channel between the cathode finger structures and the anode finger structures; disposing a first diaphragm between the first chamber and the second chamber; disposing a printed circuit board and a power supply unit in the second chamber in the housing, and the power supply unit is electrically connected to the printed circuit board; and electrically connecting the printed circuit board to the electrolytic pump unit; Wherein, in the electrochemical reaction, any side of the three-dimensional electrode pair is used to generate gas. When the first chamber is filled with a specified volume of electrolyte, at least part of the gas can escape to the In the first chamber, the gas generated by the three-dimensional electrode pair occupies at least part of the volume of the electrolyte, so that at least part of the electrolyte and/or at least part of the gas can compress the medicine bag. A drug delivery method using the electrolytic pump device for drug delivery according to claim 2, the method includes the following steps: A second diaphragm area and an electrolytic pump unit are adjacently disposed in a first chamber in a casing, wherein the casing further includes a second chamber adjacent to the first chamber, wherein the The electrolytic pump unit includes at least one three-dimensional electrode pair, the three-dimensional electrode pair has a cathode plate and an anode plate, the cathode plate has a plurality of cathode finger structures, the anode plate has a plurality of anode finger structures, and the cathode fingers The interdigitated structures and the anode finger structures are interlaced to form an interdigitated structure, wherein there is a finger flow channel between the cathode finger structures and the anode finger structures; disposing a first diaphragm between the first chamber and the second chamber; disposing a printed circuit board and a power supply unit in the second chamber in the housing, and the power supply unit is electrically connected to the printed circuit board; and electrically connecting the printed circuit board to the electrolytic pump unit; Wherein, in the electrochemical reaction, any side of the three-dimensional electrode pair is used to generate gas. When the first chamber is filled with a specified volume of electrolyte, at least part of the gas can escape to the In the first chamber, the gas generated by the three-dimensional electrode pair occupies at least part of the volume of the electrolyte, so that at least part of the electrolyte and/or at least part of the gas can compress the second membrane region.

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