TW202241892A - 用於治療弗里德希氏運動失調症（ｆｒｉｅｄｒｅｉｃｈ＇ｓ ａｔａｘｉａ）之方法及化合物 - Google Patents
用於治療弗里德希氏運動失調症（ｆｒｉｅｄｒｅｉｃｈ＇ｓ ａｔａｘｉａ）之方法及化合物 Download PDFInfo
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- PNGLEYLFMHGIQO-UHFFFAOYSA-M sodium;3-(n-ethyl-3-methoxyanilino)-2-hydroxypropane-1-sulfonate;dihydrate Chemical compound O.O.[Na+].[O-]S(=O)(=O)CC(O)CN(CC)C1=CC=CC(OC)=C1 PNGLEYLFMHGIQO-UHFFFAOYSA-M 0.000 description 1
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- LKYIPGJOXSVWPX-UHFFFAOYSA-M sodium;thiophene-2-carboxylate Chemical compound [Na+].[O-]C(=O)C1=CC=CS1 LKYIPGJOXSVWPX-UHFFFAOYSA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- VNFWTIYUKDMAOP-UHFFFAOYSA-N sphos Chemical compound COC1=CC=CC(OC)=C1C1=CC=CC=C1P(C1CCCCC1)C1CCCCC1 VNFWTIYUKDMAOP-UHFFFAOYSA-N 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- LCCKZUXKTVBEFG-KRWDZBQOSA-N tert-butyl 2-[(9S)-7-(4-aminophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetate Chemical compound C1(C2=N[C@H](C=3N(C4=C2C(C)=C(C)S4)C(C)=NN=3)CC(=O)OC(C)(C)C)=CC=C(N)C=C1 LCCKZUXKTVBEFG-KRWDZBQOSA-N 0.000 description 1
- DPHBUYIWPQZFEQ-LJAQVGFWSA-N tert-butyl 2-[(9S)-7-[4-(benzhydrylideneamino)phenyl]-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetate Chemical compound N(=C(\C1=CC=CC=C1)/C1=CC=CC=C1)\C1=CC=C(C2=N[C@H](C=3N(C=4SC(=C(C)C2=4)C)C(C)=NN=3)CC(=O)OC(C)(C)C)C=C1 DPHBUYIWPQZFEQ-LJAQVGFWSA-N 0.000 description 1
- LFKDJXLFVYVEFG-UHFFFAOYSA-N tert-butyl carbamate Chemical compound CC(C)(C)OC(N)=O LFKDJXLFVYVEFG-UHFFFAOYSA-N 0.000 description 1
- ILMRJRBKQSSXGY-UHFFFAOYSA-N tert-butyl(dimethyl)silicon Chemical group C[Si](C)C(C)(C)C ILMRJRBKQSSXGY-UHFFFAOYSA-N 0.000 description 1
- 125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- CBXCPBUEXACCNR-UHFFFAOYSA-N tetraethylammonium Chemical compound CC[N+](CC)(CC)CC CBXCPBUEXACCNR-UHFFFAOYSA-N 0.000 description 1
- 125000003039 tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 description 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 description 1
- 125000005942 tetrahydropyridyl group Chemical group 0.000 description 1
- QEMXHQIAXOOASZ-UHFFFAOYSA-N tetramethylammonium Chemical compound C[N+](C)(C)C QEMXHQIAXOOASZ-UHFFFAOYSA-N 0.000 description 1
- 125000001113 thiadiazolyl group Chemical group 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000004588 thienopyridyl group Chemical group S1C(=CC2=C1C=CC=N2)* 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 150000007970 thio esters Chemical class 0.000 description 1
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 description 1
- 125000005031 thiocyano group Chemical group S(C#N)* 0.000 description 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 description 1
- 229940113082 thymine Drugs 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
- DBGVGMSCBYYSLD-UHFFFAOYSA-N tributylstannane Chemical compound CCCC[SnH](CCCC)CCCC DBGVGMSCBYYSLD-UHFFFAOYSA-N 0.000 description 1
- 125000003866 trichloromethyl group Chemical group ClC(Cl)(Cl)* 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 125000005152 trihalomethanesulfonyl group Chemical group 0.000 description 1
- 125000004951 trihalomethoxy group Chemical group 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 125000001834 xanthenyl group Chemical group C1=CC=CC=2OC3=CC=CC=C3C(C12)* 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Photoreceptors In Electrophotography (AREA)
- Polyethers (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163135427P | 2021-01-08 | 2021-01-08 | |
| US63/135,427 | 2021-01-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW202241892A true TW202241892A (zh) | 2022-11-01 |
Family
ID=82358799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW111100817A TW202241892A (zh) | 2021-01-08 | 2022-01-07 | 用於治療弗里德希氏運動失調症（ｆｒｉｅｄｒｅｉｃｈ＇ｓ ａｔａｘｉａ）之方法及化合物 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20240124491A1 (https=) |
| EP (1) | EP4274583A4 (https=) |
| JP (1) | JP2024502469A (https=) |
| CN (1) | CN117241805A (https=) |
| AR (1) | AR124589A1 (https=) |
| AU (1) | AU2022206424A1 (https=) |
| CA (1) | CA3204523A1 (https=) |
| IL (1) | IL304322A (https=) |
| MX (1) | MX2023008153A (https=) |
| TW (1) | TW202241892A (https=) |
| WO (1) | WO2022150555A2 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2024502469A (ja) * | 2021-01-08 | 2024-01-19 | デザイン セラピューティクス，インク． | フリードライヒ運動失調症を治療するための方法及び化合物 |
| JP2025502064A (ja) * | 2022-01-06 | 2025-01-24 | デザイン セラピューティクス，インク． | フリードライヒ運動失調症を治療するための化合物及び方法 |
| CN119708005A (zh) * | 2023-09-27 | 2025-03-28 | 北京沐华生物科技有限责任公司 | 一类brd4蛋白降解剂化合物及其制备方法和应用 |
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| US20060270727A1 (en) * | 2005-05-03 | 2006-11-30 | Christian Melander | Small molecule therapeutics and uses therefor |
| RU2720237C2 (ru) * | 2013-11-18 | 2020-04-28 | Форма Терапеутикс, Инк. | Композиции, содержащие бензопиперазин, в качестве ингибиторов бромодоменов вет |
| GB201504314D0 (en) * | 2015-03-13 | 2015-04-29 | Univ Dundee | Small molecules |
| US10517877B2 (en) * | 2016-03-30 | 2019-12-31 | Wisconsin Alumni Research Foundation | Compounds and methods for modulating frataxin expression |
| PT3442972T (pt) * | 2016-04-15 | 2020-05-29 | Abbvie Inc | Inibidores de bromodomínio |
| WO2019204781A1 (en) * | 2018-04-20 | 2019-10-24 | Design Therapeutics Inc. | Methods and compounds for the treatment of genetic disease |
| EP4234550A3 (en) * | 2018-05-22 | 2023-09-06 | Design Therapeutics, Inc. | Methods and compounds for the treatment of genetic disease |
| US20220047596A1 (en) * | 2018-09-12 | 2022-02-17 | Board Of Regents, The University Of Texas System | Combination of parp inhibitor and brd4 inhibitor for the treatment of cancer |
| CN121045206A (zh) * | 2020-02-03 | 2025-12-02 | 设计治疗公司 | 用于治疗遗传疾病的方法和化合物 |
| WO2022126000A1 (en) * | 2020-12-11 | 2022-06-16 | Design Therapeutics, Inc. | Methods and compounds for modulating myotonic dystrophy 1 |
| JP2024502469A (ja) * | 2021-01-08 | 2024-01-19 | デザイン セラピューティクス，インク． | フリードライヒ運動失調症を治療するための方法及び化合物 |
-
2022
- 2022-01-07 JP JP2023541510A patent/JP2024502469A/ja active Pending
- 2022-01-07 CA CA3204523A patent/CA3204523A1/en active Pending
- 2022-01-07 AR ARP220100032A patent/AR124589A1/es unknown
- 2022-01-07 EP EP22737158.0A patent/EP4274583A4/en active Pending
- 2022-01-07 US US18/260,549 patent/US20240124491A1/en active Pending
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- 2022-01-07 MX MX2023008153A patent/MX2023008153A/es unknown
- 2022-01-07 WO PCT/US2022/011560 patent/WO2022150555A2/en not_active Ceased
- 2022-01-07 TW TW111100817A patent/TW202241892A/zh unknown
- 2022-01-07 AU AU2022206424A patent/AU2022206424A1/en active Pending
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2023
- 2023-07-09 IL IL304322A patent/IL304322A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA3204523A1 (en) | 2022-07-14 |
| IL304322A (en) | 2023-09-01 |
| MX2023008153A (es) | 2023-09-21 |
| AU2022206424A1 (en) | 2023-08-24 |
| AU2022206424A9 (en) | 2024-09-19 |
| WO2022150555A3 (en) | 2022-12-22 |
| CN117241805A (zh) | 2023-12-15 |
| JP2024502469A (ja) | 2024-01-19 |
| WO2022150555A2 (en) | 2022-07-14 |
| US20240124491A1 (en) | 2024-04-18 |
| EP4274583A4 (en) | 2025-01-22 |
| EP4274583A2 (en) | 2023-11-15 |
| AR124589A1 (es) | 2023-04-12 |
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