TW202208465A - Polymer material structure for rigid oxygen-permeable contact lenses improving user comfort and reducing corneal pathology when the user wears the rigid oxygen-permeable contact lenses - Google Patents

Abstract

The present invention relates to a method of polymerizing a polymer material structure of rigid oxygen-permeable contact lenses. The composition of the lens contains, in preset proportions, hexafluoroisopropyl methacrylate, 3-Methacryloxypropyltris-(trimethylsiloxy)-silane, 2,2-Dimethylpropanediol dimethacrylate, methacrylic acid, crosslinking agent, 2,5-Dimethyl-2,5-di(2-ethylhexanoylperoxy)hexane, and 2,2'-dihydroxy-4,4'- Dimethoxybenzophenone. These monomers can be polymerized to form a polymer cured product that has excellent oxygen permeability as well as higher hardness and mechanical strength, so that it can improve user comfort and reduce corneal pathology when the user wears the rigid oxygen-permeable contact lenses.

Description

Structure of polymer materials for rigid oxygen permeable contact lenses

The present invention relates to a polymer material structure of a rigid oxygen-permeable contact lens, especially the lens is polymerized from a plurality of monomers, and the lens has excellent oxygen permeability, high hardness and mechanical strength, so that the Improves user comfort and reduces corneal pathology when wearing rigid oxygen permeable contact lenses.

Press, with the development and innovation of various electronic and electrical products, it has brought people a lot of convenience in daily life and work, especially the advent of a large number of electronic products, which has also led to the popularization of applications in communications and the Internet, so that many People are immersed in the use of electronic products, and a large number of electronic products are used for a long time, whether it is office workers, students, or middle-aged and elderly people, covering a wide range, which leads to the phenomenon of bow-headed people, which has created many People's eyes vision impairment, injury and other conditions are becoming more and more serious, and the population of myopia is relatively increased.

Furthermore, myopia occurs due to the mismatch between the eye's ability to bend light and the length of the eye. It may be that the eye axis is too long or the corneal arc is too steep, causing the visual imaging point to fall in front of the retina. Causes blurring of vision during imaging. Therefore, in order to correct myopia, it is necessary to reduce the bending ability of the eye light. Since the corneal light bending ability accounts for about 80% of the entire eye, it is only necessary to reduce the refractive power of the cornea to achieve the effect of correcting myopia. .

At present, the main methods of correcting refractive errors include wearing glasses to correct and wear contact lenses. There are several methods of lens correction, corneal myopia surgery or wearing orthokeratology lenses. However, there are generally two types of contact lenses: soft and hard. (methylmethacrylate), PMMA), this polymethyl methacrylate is to have quite good optical properties, and its advantages have high transparency, low price and easy processing etc., but, although the oxygen permeability of polymethyl methacrylate is quite good, However, it is quite hydrophobic, and is prone to deposits on the surface of the lens, which affects the comfort and safety of the wearer.

Therefore, in order to improve the problem of hydrophobicity, the raw materials for the manufacture of contact lenses have been developed to use 2-hydroxyethyl methacrylate (HEMA). The functional group can generate hydrogen bonds with water, so it can improve the hydrophobicity problem, and hydroxyethyl methacrylate has the advantage of high oxygen permeability coefficient (DK value), which can improve wearing comfort, however, although oxygen permeability The higher the coefficient, the better the oxygen permeability, but the mechanical strength will be worse and worse. The most obvious disadvantage is the low hardness. As shown in Figure 5, the hardness of hydroxyethyl methacrylate is only up to 70duro, and the hardness is lower. The material is not suitable for making hard contact lenses.

Therefore, how to solve the above-mentioned deficiencies and inconveniences is the direction of research and improvement that the relevant practitioners in this industry are eager to study and improve.

Therefore, in view of the above deficiencies, the inventor collected relevant information, evaluated and considered from various parties, and based on years of experience accumulated in this industry, through continuous trial production and modification, before designing this kind of rigid oxygen-permeable contact lens polymer material. The inventor of the structure.

The main purpose of the present invention is that one side of the lens is formed to be attached to the eyeball The inner surface on the corneal surface of the lens, and the outer surface for eyelid contact is formed on the other side of the lens, and the composition of the lens is hexafluoroisopropyl methacrylate, 3-(isobutylene acrylate and Oxy)propyl tris(trimethylsiloxane) silane, neopentyl glycol dimethacrylate, methacrylic acid, polydimethylsiloxane methacrylate, 2,5-dimethyl-2 , 5-bis(2-ethylhexanoic acid peroxy)hexane, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, N-vinylpyrrolidone and acrylamide, namely The polymer cured product that can be polymerized by these plural monomers can have excellent oxygen permeability, and also have high hardness and mechanical strength, so as to improve the comfort of users when wearing hard oxygen permeable contact lenses degree and reduce corneal lesions.

The secondary purpose of the present invention is that the plural monomers of the lens include polymethacrylate (ethylene glycol), N-vinylpyrrolidone or acrylamide, so as to achieve the purpose of improving the overall hydrophilicity.

1: Lens

11: inner surface

12: Outer surface

[Fig. 1] is a side view of the lens of the present invention.

[Fig. 2] is a flow chart of the present invention.

[Figure 3] is the oxygen permeability test chart of the present invention.

[Fig. 4] is a hardness test chart of the present invention.

[Fig. 5] is the hardness test chart of conventional HEMA.

In order to achieve the above purpose and effect, the technical means and structure adopted by the present invention, the preferred embodiments of the present invention are hereby described in detail, and the features and functions are as follows, so as to be fully learn.

Please refer to FIG. 1, which is a side view of the lens of the present invention. It can be clearly seen from the figure that the lens 1 is a hard contact lens (such as an orthokeratology lens or a scleral lens) that can be worn on the eyeball. ), and is made of high oxygen permeability material, one side of the lens 1 is formed with an inner surface 11 attached to the corneal surface of the eyeball, and the other side of the lens 1 is formed with an outer surface 12 for eyelid contact, and The composition of the lens 1 is composed of hexafluoroisopropyl methacrylate, 3-(isobutylene oxy)propyltris(trimethylsiloxane)silane, and neopentyl glycol dimethyl silane in a preset ratio. Acrylates, methacrylic acid, polydimethylsiloxane methacrylate, 2,5-dimethyl-2,5-bis(2-ethylhexanoic acid peroxy)hexane, 2,2'- Dihydroxy-4,4'-dimethoxybenzophenone, poly(ethylene glycol) methacrylate, N-vinylpyrrolidone and acrylamide.

The proportion of the above-mentioned hexafluoroisopropyl methacrylate is less than 50%, the proportion of the 3-(isobutenyloxy)propyltris(trimethylsiloxane)silane is less than 40%, the neopentyl The proportion of alcohol dimethacrylate is less than 15%, the proportion of methacrylic acid is less than 20%, the proportion of polydimethylsiloxane methacrylate is less than 10%, the proportion of 2,5-dimethyl The proportion of -2,5-bis(2-ethylhexanoic acid peroxy)hexane is less than 1%, and the proportion of the 2,2'-dihydroxy-4,4'-dimethoxybenzophenone is less than 1%, the proportion of the polymethacrylate (ethylene glycol) ester is less than 1%, the proportion of the N-vinylpyrrolidone is less than 1%, and the proportion of the acrylamide is less than 1%.

Please refer to Figures 2, 3 and 4, which are the flow chart, oxygen permeability test chart and hardness test chart of the present invention. It can be clearly seen from the figures that the manufacturing of the raw material of the lens 1 of the present invention The method consists of the following steps:

(A) A plurality of monomers can be added into a container (such as a beaker or a batch heating stirrer), so that a solution containing a plurality of monomers is contained in the container, and the solution is heated by a heating device to a predetermined temperature. The temperature is set, so that a plurality of monomers contained in the solution produce a polymerization reaction, and then solidify to form a polymer cured product, and the plurality of monomers are composed of hexafluoroisopropyl methacrylate, 3 -(Isobutenyloxy)propyl tris(trimethylsiloxane) silane, neopentyl glycol dimethacrylate, methacrylic acid, crosslinker, 2,5-dimethyl-2,5-bis (2-ethylhexanoic acid peroxy)hexane and 2,2'-dihydroxy-4,4'-dimethoxybenzophenone.

(B) Pour the solution in the container into a vessel (such as a rod-shaped mold), and place the vessel in an oven to perform a heat curing operation at a preset temperature for a preset time, so that the solution contains a plurality of monomers A purification reaction occurs, and a polymer cured product without monomers is formed.

(C) Place the polymer cured product without monomer inside in an annealing device (such as an annealing furnace) to anneal the polymer cured product without monomer inside, and the polymer cured after the annealing treatment is cured The material can become the raw material of the lens 1, thereby completing the manufacturing operation of the present invention.

The container in the above step (A) can be filled with a solvent first, and the solvent can be anhydrous dioxane.

The cross-linking agent in the above step (A) can be polydimethylsiloxane methacrylate or polydimethylsiloxane methacrylate.

In the above step (A), the plurality of monomers in the container can be further added with polymethacrylate (ethylene glycol), N-vinylpyrrolidone or acrylamide, and the lens 1 The overall hydrophilicity can be improved by adding polymethacrylate (ethylene glycol), N-vinylpyrrolidone or acrylamide to the material.

Furthermore, the heating device in the above step (A) can be a heating plate, an alcohol lamp or other devices that can provide heat energy, and the preset temperature of the heating device can be 100°C, and during the heating process of the heating device, In order to further use a stirring device to perform stirring action.

And if the container in the above step (A) is a batch heating mixer, it can be used with a peristaltic pump, so that the solution in the container can be poured into the vessel through the peristaltic pump.

However, when the vessel in the above step (B) is placed in an oven for thermal curing, the vessel is first placed in an oven at 65° C. for at least 68 hours for thermal curing, and then heated to a temperature greater than 100° C. The monomer is re-cured, and then heated to 220 ° C, the bond between silicon and fluorine can be broken, and the molecules of the solution can be rearranged to produce a purification reaction, thereby forming a polymer cured product.

In addition, before the above step (B) is performed, a reversible addition-fragmentation transfer polymerization (RAFT) reagent can be added, so that the polymerization can be a reversible addition-fragmentation chain transfer polymerization, Its reversible addition-splitting chain transfer polymerization can polymerize -OH groups containing hydrophilic units and monomers containing long carbon chains, and through the reversible addition-splitting chain transfer polymerization, the polymerization speed can be slowed down, and further The various monomers in the solution are effectively contacted, thereby forming a high molecular weight, high dispersibility and stable high molecular polymer, so as to improve the hydrophilicity of the material, and the reversible addition and splitting chain transfer polymerization reagent can be two. Dithiobenzoates, Trithiocarhonates, Dithiobenzoates Thiocarbamates (Dithiocarbamates) or xanthates (Xanthates) and the like.

And the purification reaction in the above step (B) is preferably a reversible addition-splitting chain transfer polymerization reaction, but in practical applications, it can also be free radical polymerization, ionic polymerization, condensation A polymerization reaction such as condensation polymerization, stepwise addition polymerization or addition condensation polymerization.

After the above-mentioned step (B) of the polymerization reaction is performed, the polymer cured product can be further irradiated with gamma rays to ensure that the unpolymerized monomers are re-polymerized, so that the polymerization rate can be improved.

The oxygen permeability (DK value) of the raw material of the lens 1 in the above step (C) is between 170 and 200 barrer, and the hardness is between 76 and 81 duro. Referring to Figures 3 and 4, it is shown as In the oxygen permeability test chart and hardness test chart of the present invention, it can be clearly seen from the figures that the average value of the oxygen permeability of the raw material of the lens 1 after the test is 189 barrer, and the average value of the hardness of the raw material of the lens 1 after the test is 77duro.

In the present invention, a plurality of monomers can be added into a container, and heated to a preset temperature by a heating device, so that a plurality of monomers can be polymerized and then cured to form a polymer cured product. At this time, the solution in the container is It is thick, and the solution is poured into a vessel, and then the vessel is placed in an oven for thermal curing operation, so that the plural monomers in the solution are purified and reacted, and then rearranged to form a polymer solidified product without monomers inside, Then place the polymer cured product in the annealing equipment Set in the center to anneal the polymer cured product, and the polymer cured product after the annealing treatment can become the raw material of the lens 1, because the plurality of monomers are methacrylic acid containing a preset ratio. Hexafluoroisopropyl, 3-(isobutenyloxy)propyltris(trimethylsiloxane)silane, neopentyl glycol dimethacrylate, methacrylic acid, crosslinking agent, 2,5-dimethyl base-2,5-bis(2-ethylhexanoic acid peroxy)hexane and 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, so it can pass through these multiple monomers The polymer cured product obtained by polymerization has excellent oxygen permeability, and also has high hardness and mechanical strength, so that the user's comfort can be improved when wearing the lens 1 and corneal lesions can be reduced.

And the above-mentioned lens 1 can be made by multi-stage heating in steps (A) and (B), and the heating temperature in step (B) is greater than the heating temperature in step (A), and the multi-stage heating can be used to avoid the lens 1. The surface structure is damaged due to one high temperature heating, which can improve the product yield.

The above description is only a preferred embodiment of the present invention, which does not limit the scope of the patent of the present invention. Therefore, any simple modifications and equivalent structural changes made by using the contents of the description and drawings of the present invention should be similarly included in the Within the scope of the patent of the present invention, it is hereby stated.

To sum up, the polymer material structure of the rigid oxygen-permeable contact lens of the present invention can indeed achieve its efficacy and purpose during practical application and implementation. Therefore, the present invention is a research and development with excellent practicability, which is in line with the application of the invention patent. If you have any doubts, please do not hesitate to send a letter to instruct the inventor, and the inventor will make every effort to cooperate, and I am truly grateful.

1: Lens

11: inner surface

12: Outer surface

Claims (5)

A rigid oxygen permeable contact lens polymer material structure, one side of the lens is formed with an inner surface attached to the corneal surface of the eyeball, and the other side of the lens is formed with an outer surface for eyelid contact, and the composition of the lens is composed of Hexafluoroisopropyl methacrylate, 3-(isobutyloxy)propyltris(trimethylsiloxane)silane, neopentyl glycol dimethacrylate, methacrylic acid in preset proportions , crosslinking agent, 2,5-dimethyl-2,5-bis(2-ethylhexanoic acid peroxy)hexane and 2,2'-dihydroxy-4,4'-dimethoxydiphenyl ketone. The polymer material structure of the rigid oxygen-permeable contact lens described in item 1 of the patent application scope, wherein the proportion of the hexafluoroisopropyl methacrylate is less than 50%, the 3-(isobutylene oxy) propyl tri( The proportion of trimethylsiloxane) silane is less than 40%, the proportion of the neopentyl glycol dimethacrylate is less than 15%, the proportion of the methacrylic acid is less than 20%, and the proportion of the crosslinking agent is Less than 10%, the proportion of the 2,5-dimethyl-2,5-bis(2-ethylhexanoic acid peroxy)hexane is less than 1%, the 2,2'-dihydroxy-4,4' - The proportion of dimethoxybenzophenone is less than 1%. The polymer material structure of the rigid oxygen-permeable contact lens as described in item 1 of the claimed scope, wherein the cross-linking agent is polydimethylsiloxane methacrylate or polydimethylsiloxane methacrylate . The polymer material structure of the rigid oxygen-permeable contact lens as described in item 1 of the scope of the patent application, wherein polymethacrylate (ethylene glycol), N-vinylpyrrolidone or acrylamide are added to the lens components. As described in item 4 of the patent application scope, the polymer material structure of the rigid oxygen-permeable contact lens structure, wherein the proportion of the poly(ethylene glycol) methacrylate is less than 1%, the proportion of the N-vinylpyrrolidone is less than 1%, and the proportion of the acrylamide is less than 1%.

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