TW202138448A - Anti-blue light contact lens, composition and manufacturing method thereof - Google Patents
Anti-blue light contact lens, composition and manufacturing method thereof Download PDFInfo
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- TW202138448A TW202138448A TW109111035A TW109111035A TW202138448A TW 202138448 A TW202138448 A TW 202138448A TW 109111035 A TW109111035 A TW 109111035A TW 109111035 A TW109111035 A TW 109111035A TW 202138448 A TW202138448 A TW 202138448A
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
- C08F220/20—Esters of polyhydric alcohols or phenols, e.g. 2-hydroxyethyl (meth)acrylate or glycerol mono-(meth)acrylate
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/01—Use of inorganic substances as compounding ingredients characterized by their specific function
- C08K3/013—Fillers, pigments or reinforcing additives
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F2/00—Processes of polymerisation
- C08F2/44—Polymerisation in the presence of compounding ingredients, e.g. plasticisers, dyestuffs, fillers
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F2/00—Processes of polymerisation
- C08F2/46—Polymerisation initiated by wave energy or particle radiation
- C08F2/48—Polymerisation initiated by wave energy or particle radiation by ultraviolet or visible light
- C08F2/50—Polymerisation initiated by wave energy or particle radiation by ultraviolet or visible light with sensitising agents
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/04—Acids; Metal salts or ammonium salts thereof
- C08F220/06—Acrylic acid; Methacrylic acid; Metal salts or ammonium salts thereof
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
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- G—PHYSICS
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Abstract
Description
本發明係有關於一種防藍光隱形眼鏡、其組合物及製備方法,尤指一種兼顧防藍光功能及美觀效果的隱形眼鏡、其組合物及製備方法。The present invention relates to an anti-blue light contact lens, its composition and a preparation method, in particular to a contact lens that has both anti-blue light function and aesthetic effect, and its composition and preparation method.
科技發展日新月異,3C、電子產品等幾乎成為現代生活不可缺少的必需品。惟如LED燈以及平板電腦、電視、智慧型手機的螢幕都會釋放藍光,而使用3C產品時,眼睛不可避免地會直視螢幕所發出的藍光。藍光是可見光中最靠近紫外線光波之能量較強的部分,波長介於380nm~530nm之間。其波長較短,會提前在視網膜前聚焦,容易造成散射,因此眼睛需更用力聚焦而難以放鬆,長時間下來易導致眼睛視物的影像對比及清晰度降低,且增加眼睛疲勞。With the rapid development of science and technology, 3C and electronic products have almost become indispensable necessities of modern life. However, LED lights and the screens of tablet computers, TVs, and smart phones emit blue light. When using 3C products, the eyes will inevitably look directly at the blue light emitted by the screen. Blue light is the strongest part of visible light that is closest to the ultraviolet light wave, and its wavelength is between 380nm and 530nm. Its shorter wavelength will focus in front of the retina in advance, which is likely to cause scattering. Therefore, the eyes need to focus harder and it is difficult to relax. Over a long period of time, the image contrast and clarity of the eye's vision will be reduced, and eye fatigue will increase.
近年來,已有多項研究表示藍光會提高視覺細胞對光的敏感度以及光氧化反應而導致細胞的死亡,輕則影響視力,重則將致使視網膜細胞損傷,特別是使光敏感度較高的黃斑部損傷。In recent years, a number of studies have shown that blue light can increase the sensitivity of visual cells to light and the photooxidation reaction leads to cell death. It affects vision in the least, and damages retinal cells, especially the macular area with high light sensitivity. damage.
藍光射入眼睛後不會被角膜和水晶體吸收,其可穿透角膜與水晶體直射入黃斑部。若吸收過多藍光,初期眼睛會有刺痛、畏光等症狀,長期則黃斑部發炎、水腫,且可能在黃斑部中央形成隱結。一旦隱結破裂導致出血,將造成中央視力缺損,無法正眼看清楚事物。過去黃斑部病變好發於老年人,惟現代隨著生活的改變以及藍光刺激的增加,發病的年齡層有往下降的趨勢,抗藍光已經成為重要之課題。Blue light will not be absorbed by the cornea and lens after it enters the eye, and it can penetrate the cornea and lens and be directed into the macula. If too much blue light is absorbed, the eyes will have tingling, photophobia and other symptoms in the initial stage, but in the long term, the macula will become inflamed and edema, and a crypt may form in the center of the macula. Once the crypts rupture and cause bleeding, the central vision will be impaired and you will not be able to see things clearly. In the past, macular lesions were more likely to occur in the elderly. However, in modern times, with the change of life and the increase of blue light stimulation, the age group of onset tends to decrease. Anti-blue light has become an important issue.
針對前述藍光所產生的各種問題,除了盡量減少藍光接觸外,目前較為積極的解決方法是配戴抗藍光眼鏡。現有市售抗藍光眼鏡為配戴於眼睛外部的眼鏡,其主要是經由在玻璃或塑膠鏡片上塗佈一層抗藍光塗料,再將玻璃或塑膠鏡片組裝於鏡框上而製得。但於實際使用時,由於配戴於眼睛外部的眼鏡與眼睛之間具有一段距離,藍光不一定會通過鏡片而進入配戴者的眼睛,因此仍存有直接進入配戴者眼睛的機率。所以,現有市售抗藍光眼鏡無法完全阻隔藍光,且對於習慣配戴隱形眼鏡的族群無法提供防藍光的保護。In view of the various problems caused by blue light, in addition to minimizing blue light exposure, the current more active solution is to wear anti-blue light glasses. The existing commercially available anti-blue glasses are glasses worn outside the eyes, which are mainly made by coating a layer of anti-blue paint on glass or plastic lenses, and then assembling the glass or plastic lenses on the frame. However, in actual use, due to the distance between the glasses worn outside the eyes and the eyes, blue light does not necessarily enter the wearer's eyes through the lenses, so there is still a possibility of directly entering the wearer's eyes. Therefore, the existing commercially available anti-blue light glasses cannot completely block blue light, and cannot provide blue light protection for people who are accustomed to wearing contact lenses.
因此,如能針對貼附於眼球表面的隱形眼鏡添加抗藍光效果,應更有助於阻隔藍光及保護配戴者的眼睛。對此,有如中華民國專利第M487455號揭露的「具有濾藍光及抗UV功能之彩色隱形眼鏡」,其由上、中間及下層鏡片所組成,且以上層鏡片內之濾藍光鍍膜劑來達成減低藍光入射眼睛,惟該種隱形眼鏡除耗時、耗工及耗成本外,並有傷害眼睛之虞。Therefore, if the anti-blue light effect can be added to the contact lens attached to the surface of the eyeball, it should be more helpful to block blue light and protect the wearer's eyes. In this regard, such as the "color contact lens with blue light filtering and anti-UV function" disclosed in the Republic of China Patent No. M487455, which is composed of upper, middle and lower lenses, and the blue light filter coating agent in the upper lens to achieve reduction Blue light enters the eyes, but in addition to time-consuming, labor-intensive and cost-consuming contact lenses, there is a risk of eye damage.
本發明提供一種防藍光隱形眼鏡組合物,適於製備具防藍光功能、避免配戴者發生視覺疲勞、避免造成視覺色差,且有助提升美觀效果的隱形眼鏡。The present invention provides an anti-blue light contact lens composition, which is suitable for preparing contact lenses with anti-blue light function, avoiding visual fatigue of the wearer, avoiding visual chromatic aberration, and helping to improve the aesthetic effect.
本發明還提供一種防藍光隱形眼鏡組合物的製備方法,適於製備防藍光功能與美觀兼具的隱形眼鏡。The invention also provides a preparation method of the anti-blue light contact lens composition, which is suitable for preparing contact lenses with anti-blue light function and beautiful appearance.
本發明還提供一種防藍光隱形眼鏡,具防藍光功能且美觀,有助提升配戴者的使用感受。The invention also provides an anti-blue light contact lens, which has an anti-blue light function and is beautiful, which helps improve the wearer's use experience.
本發明的其他目的和優點可以從本發明所揭露的技術特徵中得到進一步的了解。The other objectives and advantages of the present invention can be further understood from the technical features disclosed in the present invention.
為達上述之一或部分或全部目的或是其他目的,本發明所提供的防藍光隱形眼鏡組合物包括至少一水膠單體、黃色染料、藍色顏料、交聯劑以及光起始劑,其中黃色染料與藍色顏料的含量佔組合物的0.01 wt至1 wt%。In order to achieve one or part or all of the above objectives or other objectives, the anti-blue light contact lens composition provided by the present invention includes at least one hydrogel monomer, a yellow dye, a blue pigment, a crosslinking agent and a photoinitiator, The content of the yellow dye and the blue pigment accounts for 0.01 wt% to 1 wt% of the composition.
在本發明的一實施例中,上述之黃色染料包含反應性黃色染料,該藍色顏料包含酞菁藍15,且該黃色染料與該藍色顏料的含量比例為11:1~7:1。In an embodiment of the present invention, the above-mentioned yellow dye includes a reactive yellow dye, the blue pigment includes phthalocyanine blue 15, and the content ratio of the yellow dye to the blue pigment is 11:1-7:1.
在本發明的一實施例中,上述之至少一種水膠單體含有一個不飽和烴基的親水分子,且為丙烯酸、甲基丙烯酸、N-乙烯吡咯烷酮、羥烷基(甲基)丙烯酸酯、二羥烷基(甲基)丙烯酸酯、2-羥乙基甲基丙烯酸酯或其組合,且至少一種水膠單體的含量為50 wt%至99 wt%。In an embodiment of the present invention, at least one of the above-mentioned hydrogel monomers contains an unsaturated hydrocarbon-based hydrophilic molecule, and is acrylic acid, methacrylic acid, N-vinylpyrrolidone, hydroxyalkyl (meth)acrylate, two Hydroxyalkyl (meth)acrylate, 2-hydroxyethyl methacrylate or a combination thereof, and the content of at least one hydrogel monomer is 50 wt% to 99 wt%.
在本發明的一實施例中,上述之交聯劑為乙二醇二甲基丙烯酸酯、四乙二醇二甲基丙烯酸酯、二乙二醇二甲基丙烯酸酯、聚乙二醇二甲基丙烯酸酯、三羥甲基丙烷三甲基丙烯酸酯、季戊四醇四甲基丙烯酸酯、雙酚A二甲基丙烯酸酯、甲基丙烯酸乙烯酯或其組合,且交聯劑的含量為0.01 wt%至2.5 wt%。In an embodiment of the present invention, the above-mentioned crosslinking agent is ethylene glycol dimethacrylate, tetraethylene glycol dimethacrylate, diethylene glycol dimethacrylate, polyethylene glycol dimethyl acrylate Base acrylate, trimethylolpropane trimethacrylate, pentaerythritol tetramethacrylate, bisphenol A dimethacrylate, vinyl methacrylate or a combination thereof, and the content of the crosslinking agent is 0.01 wt% To 2.5 wt%.
在本發明的一實施例中,上述之光起始劑為氧化雙(2,4,6-三甲基苯甲醯基)苯基膦、安息香乙醚、苯基二甲基縮酮、α,α-二乙氧基苯乙酮、2-羥基-2-甲基-1-苯基-1-丙酮或其組合,且光起始劑的含量為0.01 wt%至2.5 wt%。In an embodiment of the present invention, the aforementioned photoinitiator is bis(2,4,6-trimethylbenzyl)phenylphosphine oxide, ethyl benzoin, phenyldimethyl ketal, α, α-diethoxyacetophenone, 2-hydroxy-2-methyl-1-phenyl-1-acetone or a combination thereof, and the content of the photoinitiator is 0.01 wt% to 2.5 wt%.
在本發明的一實施例中,上述之組合物更包含紫外光吸收劑,紫外光吸收劑為2-[3-(2H-苯并三唑-2-基)-4-羥基苯基]乙基2-甲基丙烯酸酯、2,2',4,4'-四羥基二苯甲酮或其組合,且紫外光吸收劑的含量為0.01 wt%至1.5wt%。In an embodiment of the present invention, the above-mentioned composition further comprises an ultraviolet light absorber, and the ultraviolet light absorber is 2-[3-(2H-benzotriazol-2-yl)-4-hydroxyphenyl]ethyl 2-methacrylate, 2,2',4,4'-tetrahydroxybenzophenone or a combination thereof, and the content of the ultraviolet light absorber is 0.01 wt% to 1.5 wt%.
為達上述之一或部分或全部目的或是其他目的,本發明所提供的防藍光隱形眼鏡的製備方法包括提供模具,且所述模具包含公模及母模;配製防藍光隱形眼鏡組合物,且所述組合物包含黃色染料以及藍色顏料;將組合物注入母模,再將公模與母模壓合;進行光固化並形成鏡片本體;以及進行水化並形成隱形眼鏡。In order to achieve one or part or all of the above objectives or other objectives, the method for preparing anti-blue light contact lenses provided by the present invention includes providing a mold, and the mold includes a male mold and a female mold; preparing an anti-blue light contact lens composition, And the composition includes yellow dye and blue pigment; the composition is injected into the master mold, and then the male mold and the master mold are pressed together; the light curing is performed to form the lens body; and the hydration is performed to form the contact lens.
在本發明的一實施例中,上述之母模之內部表面移印有彩色圖案。In an embodiment of the present invention, the inner surface of the above-mentioned master mold is pad-printed with a color pattern.
在本發明的一實施例中,上述配製防藍光隱形眼鏡組合物的步驟更包含混合至少一水膠單體、黃色染料、藍色顏料、交聯劑以及光起始劑。In an embodiment of the present invention, the step of preparing the anti-blue light contact lens composition further includes mixing at least one hydrogel monomer, yellow dye, blue pigment, crosslinking agent and photoinitiator.
在本發明的一實施例中,上述配製防藍光隱形眼鏡組合物的步驟更包含混合至少一水膠單體、黃色染料、藍色顏料、交聯劑、光起始劑以及紫外光吸收劑。In an embodiment of the present invention, the step of preparing the anti-blue light contact lens composition further includes mixing at least one hydrogel monomer, yellow dye, blue pigment, crosslinking agent, photoinitiator and ultraviolet light absorber.
在本發明的一實施例中,上述進行光固化並形成鏡片本體的步驟更包含以紫外光照射母模內之組合物,使組合物行光聚合反應並形成鏡片本體。In an embodiment of the present invention, the step of photocuring and forming the lens body further includes irradiating the composition in the master mold with ultraviolet light to cause the composition to undergo photopolymerization to form the lens body.
在本發明的一實施例中,上述之方法更包括取開公模以及留下鏡片本體於母模內,以進行水化並形成隱形眼鏡。In an embodiment of the present invention, the above method further includes removing the male mold and leaving the lens body in the female mold to perform hydration and form contact lenses.
在本發明的一實施例中,上述進行水化並形成隱形眼鏡的步驟更包含以40~100℃的溫度進行水化而形成隱形眼鏡。In an embodiment of the present invention, the step of performing hydration and forming a contact lens further includes performing hydration at a temperature of 40-100° C. to form a contact lens.
在本發明的一實施例中,上述之方法更包括進行隱形眼鏡的滅菌。In an embodiment of the present invention, the above-mentioned method further includes sterilizing the contact lens.
在本發明的一實施例中,上述滅菌的步驟包含將隱形眼鏡浸潤於緩衝液並以高溫滅菌。In an embodiment of the present invention, the above-mentioned sterilization step includes immersing the contact lens in a buffer solution and sterilizing it at a high temperature.
為達上述之一或部分或全部目的或是其他目的,本發明所提供的防藍光隱形眼鏡包含前述組合物,且對波長380至460 nm的光具有小於75%的穿透率,對波長於380至780 nm的光下具有大於85%的穿透率。In order to achieve one or part or all of the above objectives or other objectives, the anti-blue light contact lens provided by the present invention comprises the aforementioned composition, and has a transmittance of less than 75% for light with a wavelength of 380 to 460 nm, and has a transmittance of less than 75% for the wavelength of It has a transmittance of greater than 85% under light from 380 to 780 nm.
在本發明的一實施例中,上述之防藍光隱形眼鏡具有綠色、藍綠色或藍色調。In an embodiment of the present invention, the aforementioned anti-blue light contact lens has a green, blue-green or blue hue.
本發明因包括黃色染料,因此能吸收波長在藍光範圍的可見光,有助於減少高能光傳遞至眼睛的量,降低眼睛疲勞、視力減低或視覺細胞損傷的機會。本發明因包括藍色顏料,因此有助於使所述防藍光隱形眼鏡、以所述組合物製成的防藍光隱形眼鏡,或以所述方法製成的防藍光隱形眼性具備適當之色調,提升眼鏡外觀以及配戴者的使用感受。Since the present invention includes a yellow dye, it can absorb visible light with a wavelength in the blue range, which helps to reduce the amount of high-energy light delivered to the eyes, and reduces the chances of eye fatigue, reduced vision or visual cell damage. Since the present invention includes blue pigments, it is helpful to make the blue light-resistant contact lenses, blue light-resistant contact lenses made with the composition, or blue light-resistant contact lenses made by the method have an appropriate hue , Improve the appearance of the glasses and the use experience of the wearer.
為讓本發明之上述和其他目的、特徵和優點能更明顯易懂,下文特舉實施例,並配合所附圖式,作詳細說明如下。In order to make the above and other objects, features and advantages of the present invention more comprehensible, the following specific examples are given in conjunction with the accompanying drawings, which are described in detail as follows.
本發明提供一種防藍光隱形眼鏡的組合物,其包含至少一種水膠單體 (hydrogel monomer)、黃色染料、藍色顏料、交聯劑 (crosslinker)以及光起始劑 (photoinitiator)。The present invention provides an anti-blue light contact lens composition, which comprises at least one hydrogel monomer, a yellow dye, a blue pigment, a crosslinker and a photoinitiator.
水膠單體構成隱形眼鏡的鏡片主體,其賦予鏡片主體機械強度,且可影響所形成隱形眼鏡的含水量。由不同水膠單體形成的鏡片本體可具有不同的保濕特性。水膠單體經聚合反應形成鏡片本體。在本發明實施例中,水膠單體可為任何能經光聚合反應且用於隱形眼鏡之鏡片主體的單體。較佳而言,本發明實施例之水膠單體含有一個不飽和烴基的親水分子且例如為丙烯酸、甲基丙烯酸 (methacrylic acid,MAA)、N-乙烯吡咯烷酮 (N -vinyl pyrrolidone)、羥烷基(甲基)丙烯酸酯、二羥烷基(甲基)丙烯酸酯、2-羥乙基甲基丙烯酸酯 (2-hydroxyethyl methacrylate,HEMA)或其組合,但不以此為限。在一實施態樣中,兩種以上的水膠單體如2-羥乙基甲基丙烯酸酯 (2-hydroxyethyl methacrylate,HEMA)及甲基丙烯酸 (methacrylic acid,MAA)用於形成鏡片本體。水膠單體的含量佔防藍光隱形眼鏡組合物的50 wt%至99 wt%。在其他實施例中,可選用能經熱聚合反應形成鏡片本體的水膠單體。The water glue monomer constitutes the lens body of the contact lens, which imparts mechanical strength to the lens body and can affect the water content of the formed contact lens. The lens body formed by different hydrogel monomers can have different moisturizing properties. The water glue monomer is polymerized to form the lens body. In the embodiment of the present invention, the water gel monomer can be any monomer that can undergo photopolymerization and used in the lens body of a contact lens. Preferably, the water glue monomer of the embodiment of the present invention contains a hydrophilic molecule of an unsaturated hydrocarbon group and is, for example, acrylic acid, methacrylic acid (MAA), N-vinyl pyrrolidone (N-vinyl pyrrolidone), and hydroxyalkane. Alkyl (meth)acrylate, dihydroxyalkyl (meth)acrylate, 2-hydroxyethyl methacrylate (HEMA) or a combination thereof, but not limited thereto. In one embodiment, two or more hydrogel monomers such as 2-hydroxyethyl methacrylate (HEMA) and methacrylic acid (MAA) are used to form the lens body. The content of the water gel monomer accounts for 50 wt% to 99 wt% of the anti-blue light contact lens composition. In other embodiments, a hydrogel monomer that can form the lens body through thermal polymerization can be selected.
水膠單體在交聯劑與光起始劑的同時存在下,可經光聚合反應形成鏡片本體。交聯劑可以使用任何用於製備隱形眼鏡的交聯劑,且可依據所用的水膠單體進行選擇。本發明實施例之交聯劑例如為乙二醇二甲基丙烯酸酯 (ethylene glycol dimethacrylate,EGDMA)、四乙二醇二甲基丙烯酸酯 (tetraethylene glycol dimethacrylate)、二乙二醇二甲基丙烯酸酯 (diethylene glycol dimethacrylate)、聚乙二醇二甲基丙烯酸酯 (polyethylene glycol dimethacrylate)、三羥甲基丙烷三甲基丙烯酸酯 (trimethylolpropanetrimethacrylate,TMPTMA)、季戊四醇四甲基丙烯酸酯 (penterythritoltetramethacrylate)、雙酚A二甲基丙烯酸酯(bisphenol A dimethacrylate)、甲基丙烯酸乙烯酯 (vinyl methacrylate)或其組合。交聯劑的含量較佳佔防藍光隱形眼鏡組合物的0.01 wt%至2.5 wt%。In the presence of the crosslinking agent and the photoinitiator, the hydrogel monomer can undergo photopolymerization to form the lens body. The cross-linking agent can be any cross-linking agent used in the preparation of contact lenses, and can be selected according to the water glue monomer used. The crosslinking agent of the embodiment of the present invention is, for example, ethylene glycol dimethacrylate (EGDMA), tetraethylene glycol dimethacrylate (tetraethylene glycol dimethacrylate), and diethylene glycol dimethacrylate. (diethylene glycol dimethacrylate), polyethylene glycol dimethacrylate, trimethylolpropanetrimethacrylate (TMPTMA), pentaerythritol tetramethacrylate, bisphenol A Dimethacrylate (bisphenol A dimethacrylate), vinyl methacrylate (vinyl methacrylate) or a combination thereof. The content of the cross-linking agent is preferably 0.01 wt% to 2.5 wt% of the blue light prevention contact lens composition.
光起始劑可以使用任何用於製備隱形眼鏡的光起始劑,且可以依據所用的水膠單體進行選擇。本發明實施例之光起始劑例如為氧化雙 (2,4,6-三甲基苯甲醯基)苯基膦 (bis(2,4,6-trimethylbenzoyl)phenylphosphine oxide)、安息香乙醚 (benzoin ethyl ether)、苯基二甲基縮酮 (benzyl dimethyl ketal)、α,α-二乙氧基苯乙酮 (α,α-diethoxyacetophenone)、2-羥基-2-甲基-1-苯基-1-丙酮 (2-Hydroxy-2-methylpropiophenone)或其組合。光起始劑的含量較佳佔防藍光隱形眼鏡組合物的0.01 wt%至2.5 wt%。The photoinitiator can be any photoinitiator used in the preparation of contact lenses, and can be selected according to the water gel monomer used. The photoinitiator in the embodiment of the present invention is, for example, bis(2,4,6-trimethylbenzoyl)phenylphosphine oxide, benzoin ethyl ether), phenyl dimethyl ketal (benzyl dimethyl ketal), α,α-diethoxyacetophenone (α,α-diethoxyacetophenone), 2-hydroxy-2-methyl-1-phenyl- 1-acetone (2-Hydroxy-2-methylpropiophenone) or a combination thereof. The content of the photoinitiator is preferably 0.01 wt% to 2.5 wt% of the anti-blue light contact lens composition.
本發明實施例之黃色染料為反應性黃色染料 (Reactive Yellow 15),然不以此為限,且亦可採用其他一或多種黃色染料、黃色顏料。反應性黃色染料為乙烯碸型活性基染料,具有水溶性佳的特性,且於可見光約390~430 nm的波長範圍有明顯吸收峰,可有效阻擋藍光。本發明實施例之藍色顏料為酞菁藍15 (Phthalocyanine Blue 15),然不以此為限,且亦可採用其他一或多種藍色顏料、藍色染料。藍色顏料有助於調整所形成隱形眼鏡的色調。相較於僅使用黃色染料所形成之隱形眼鏡呈現黃色調,含有黃色染料及藍色顏料之隱形眼鏡微呈現綠、藍綠或藍色調。藍色顏料不影響黃色染料吸收藍光波長,且隱形眼鏡的綠、藍綠或藍色調有助避免配戴者發生視覺疲勞、避免造成視覺色差,且有助提升美觀效果。黃色染料以及藍色顏料的含量較佳佔防藍光隱形眼鏡組合物的0.01 wt至1 wt%。黃色染料與藍色顏料的比例可任意,但黃色染料的量較佳多於藍色顏料。黃色染料與藍色顏料的比例例如為11:1~7:1在一實施態樣中,例如使用0.14 g黃色染料以及 0.02 g藍色顏料。The yellow dye in the embodiment of the present invention is a reactive yellow dye (Reactive Yellow 15), but it is not limited to this, and one or more other yellow dyes and yellow pigments may also be used. Reactive yellow dyes are ethylene-based reactive dyes that have good water solubility, and have obvious absorption peaks in the wavelength range of about 390 to 430 nm for visible light, which can effectively block blue light. The blue pigment in the embodiment of the present invention is Phthalocyanine Blue 15 (Phthalocyanine Blue 15), but it is not limited to this, and one or more other blue pigments and blue dyes may also be used. The blue pigment helps to adjust the hue of the formed contact lens. In contrast to contact lenses formed using only yellow dyes, which have a yellow hue, contact lenses containing yellow dyes and blue pigments have a slightly green, blue-green or blue hue. The blue pigment does not affect the absorption of the blue wavelength by the yellow dye, and the green, blue-green or blue tone of the contact lens can help prevent the wearer from visual fatigue, avoid visual chromatic aberration, and help improve the aesthetic effect. The content of the yellow dye and the blue pigment is preferably 0.01 wt% to 1 wt% of the anti-blue light contact lens composition. The ratio of the yellow dye to the blue pigment can be arbitrary, but the amount of the yellow dye is preferably more than that of the blue pigment. The ratio of the yellow dye to the blue pigment is, for example, 11:1-7:1. In one embodiment, for example, 0.14 g of yellow dye and 0.02 g of blue pigment are used.
防藍光隱形眼鏡之組合物可更包含紫外光吸收劑 (UV blocker)。紫外光吸收劑可以使用任何用於製備隱形眼鏡的紫外光吸收劑,且可以依據所用的水膠單體進行選擇。本發明實施例之紫外光吸收劑例如為2-[3-(2H-苯并三唑-2-基)-4-羥基苯基]乙基2-甲基丙烯酸酯 (2-[3-(2H-Benzotriazol-2-yl)-4-hydroxyphenyl]ethyl methacrylate)、2,2',4,4'-四羥基二苯甲酮 (2,2',4,4'-Tetrahydroxybenzophenone)或其組合。紫外光吸收劑的含量較佳佔防藍光隱形眼鏡組合物的0.01 wt%至1.5wt%。The anti-blue light contact lens composition may further include a UV blocker. The ultraviolet light absorber can be any ultraviolet light absorber used in the preparation of contact lenses, and can be selected according to the water glue monomer used. The ultraviolet light absorber of the embodiment of the present invention is, for example, 2-[3-(2H-benzotriazol-2-yl)-4-hydroxyphenyl]ethyl 2-methacrylate (2-[3-( 2H-Benzotriazol-2-yl)-4-hydroxyphenyl]ethyl methacrylate), 2,2',4,4'-Tetrahydroxybenzophenone (2,2',4,4'-Tetrahydroxybenzophenone) or a combination thereof. The content of the ultraviolet light absorber is preferably 0.01 wt% to 1.5 wt% of the anti-blue light contact lens composition.
本發明還提供一種防藍光隱形眼鏡的製備方法,包含步驟S910~S950。請參圖1,步驟S910為提供模具,且模具包含公模及母模。模具可為射出成型的光學模,其中母模之內部表面可印上圖案,且圖案較佳為彩色。步驟S920為配製防藍光隱形眼鏡組合物(以下或簡稱組合物)。組合物包含前述成分,即至少一種水膠單體、黃色染料、藍色顏料、交聯劑以及光起始劑,且較佳包含紫外光吸收劑。The present invention also provides a method for preparing blue light-proof contact lenses, including steps S910 to S950. Please refer to FIG. 1. Step S910 is to provide a mold, and the mold includes a male mold and a female mold. The mold may be an injection molding optical mold, wherein the internal surface of the master mold can be printed with a pattern, and the pattern is preferably in color. Step S920 is to prepare an anti-blue light contact lens composition (hereinafter or simply referred to as the composition). The composition contains the aforementioned ingredients, namely at least one hydrogel monomer, yellow dye, blue pigment, crosslinking agent and photoinitiator, and preferably contains an ultraviolet light absorber.
實施方式1:Implementation mode 1:
在實施方式1中,依步驟S920配製組合物1~6,並另配製對照組(對照組1)。組合物1~6及對照組1各成分之含量如表1所示。對照組1與組合物1~6的差異在於黃色染料與藍色顏料的含量。
表1:組合物1~6與對照組(對照組1)的各成分配比
接著介紹步驟S930。步驟S930為將組合物注入母模,再將公模與母模壓合。壓合之條件可據已知方法,本發明實施例不對此作限制。步驟S940為進行光固化並形成鏡片本體。在本發明實施例中,步驟S940可更以紫外光照射含水膠單體之組合物,使其行光聚合反應形成乾的鏡片本體。光照之條件可依例如光源的波長決定,例如依385 nm的紫外光決定光照時間,惟本發明實施例不對此作限制。步驟S950為進行水化並形成隱形眼鏡。Next, step S930 is introduced. Step S930 is to inject the composition into the female mold, and then press the male mold and the female mold together. The conditions of pressing can be according to known methods, and the embodiment of the present invention does not limit this. Step S940 is to perform light curing and form the lens body. In the embodiment of the present invention, in step S940, ultraviolet light may be further used to irradiate the composition of the aqueous gel monomer to undergo photopolymerization to form a dry lens body. The lighting conditions can be determined by, for example, the wavelength of the light source, for example, the lighting time is determined by 385 nm ultraviolet light, but the embodiment of the present invention does not limit this. Step S950 is to perform hydration and form contact lenses.
在進行水化前,可先將公模取開,留下鏡片本體於母模內。進行步驟S950時,母模可連同鏡片本體一同置放於水化槽內,進行加熱及水化而形成濕的鏡片本體,即隱形眼鏡。隱形眼鏡後續可再接受滅菌處理。舉例來說,於步驟S950所獲得之隱形眼鏡接著可放入包裝杯中,注入緩衝液,再封包滅菌。緩衝液可為PBS緩衝液,包含Na2 HPO4 、KH2 PO4 、NaCl、KCl或其組合,但不以此為限。舉例來說,亦可為硼酸系緩衝液。因步驟S910提供之母模的內部表面可印上彩色圖案,因此在步驟S930~S940時,彩色圖案與組合物結合,在步驟S950中,彩色圖案隨鏡片本體的水化而離開母模。所得之隱形眼鏡在表面因此可具有彩色圖案。Before hydration, the male mold can be removed first, leaving the lens body in the female mold. When step S950 is performed, the master mold can be placed in the hydration tank together with the lens body, and heated and hydrated to form a wet lens body, that is, a contact lens. The contact lens can be sterilized later. For example, the contact lens obtained in step S950 can then be put into a packaging cup, filled with a buffer solution, and packaged and sterilized. The buffer can be a PBS buffer, including Na 2 HPO 4 , KH 2 PO 4 , NaCl, KCl, or a combination thereof, but is not limited to this. For example, it may also be a boric acid buffer. Since the inner surface of the master mold provided in step S910 can be printed with color patterns, in steps S930 to S940, the color patterns are combined with the composition. In step S950, the color patterns leave the master mold as the lens body is hydrated. The resulting contact lens can therefore have a colored pattern on the surface.
實施方式2:Implementation mode 2:
在實施方式2中,將實施方式1之組合物1~6分別用於步驟S930~S950,並經滅菌而形成防藍光隱形眼鏡樣品1~6。對照組(對照組1)亦以相同條件處理,製成對照組(對照組1)隱形眼鏡。實施方式2所用之參數如表2所示。
表2:製備參數
需注意的是,實施方式2是以相同條件將組合物1~6製成隱形眼鏡。惟可知的是,在S930~S950以及滅菌等各步驟,亦可分別以其他條件如異於表2之光固化時間、水化溫度或緩衝液處理組合物1~6。另外,表2所列參數亦可用於組合物1~6以外之組合物。It should be noted that in the second embodiment, the compositions 1 to 6 are made into contact lenses under the same conditions. However, it is known that in each step of S930~S950 and sterilization, other conditions such as light curing time, hydration temperature or buffer treatment composition 1~6 different from Table 2 can also be used. In addition, the parameters listed in Table 2 can also be used for compositions other than compositions 1 to 6.
就實施方式2所得之樣品1~6及對照組(對照組1),可進一步做光穿透率的測試,結果示於圖2~3及表3。
表3:防藍光率
如圖2~3所示,防藍光隱形眼鏡與對照組(對照組1)隱形眼鏡皆可抗紫外光。380 nm以下波長之穿透率(T%)趨近零。然而,相較於對照組(對照組1),防藍光隱形眼鏡還可抗藍光。如圖2所示,防藍光隱形眼鏡允許可見光穿過,而又可降低在藍光波長範圍之可見光的穿透率。在本發明實施例中,防藍光隱形眼鏡允許波長380至780 nm的光大於88%的穿透率,且使波長380至460nm的光的穿透率小於75。藍光穿透率或防藍光率大致受到組合物所含黃色染料所影響。在本發明一實施例中,0.14 wt%的黃色染料可達到使波長380至780 nm的光的穿透率大於88%、波長380至460nm的光的穿透率小於75%的效果。相對於此,對照組1隱形眼鏡使大部分在藍光波長的光能通過,僅阻擋約3%的藍光。As shown in Figures 2 to 3, the anti-blue light contact lens and the control group (control group 1) can both resist ultraviolet light. The transmittance (T%) for wavelengths below 380 nm approaches zero. However, compared to the control group (Control Group 1), the anti-blue light contact lens can also resist blue light. As shown in Figure 2, the anti-blue light contact lens allows visible light to pass through, and can reduce the transmittance of visible light in the blue wavelength range. In the embodiment of the present invention, the anti-blue light contact lens allows a transmittance of light with a wavelength of 380 to 780 nm to be greater than 88%, and the transmittance of light with a wavelength of 380 to 460 nm is less than 75. The blue light transmittance or blue light prevention rate is roughly affected by the yellow dye contained in the composition. In an embodiment of the present invention, 0.14 wt% of the yellow dye can achieve the effect of making the transmittance of light with a wavelength of 380 to 780 nm greater than 88%, and the transmittance of light with a wavelength of 380 to 460 nm less than 75%. In contrast, the contact lens of the control group 1 allows most of the light energy at the blue wavelength to pass, and only blocks about 3% of the blue light.
如表2~3所示,黃色染料與藍色顏料所佔比例愈多,樣品的防藍光率也提高。含有0.07~0.20 wt%的黃色染料與藍色顏料的防藍光隱形眼鏡允許波長380至780 nm的光的穿透率大於85%,且使波長380至460nm的光的穿透率小於70%。As shown in Tables 2 to 3, the greater the proportion of yellow dye to blue pigment, the higher the anti-blue light rate of the sample. The anti-blue contact lens containing 0.07~0.20 wt% of yellow dye and blue pigment allows the transmittance of light with a wavelength of 380 to 780 nm to be greater than 85%, and the transmittance of light with a wavelength of 380 to 460 nm is less than 70%.
實施方式3:Implementation mode 3:
在實施方式3中,依步驟S920配製組合物7,並另配製對照組(對照組2)。組合物7所含的黃色染料佔其總重的0.13 wt%,並依黃色染料與藍色顏料為7:1的比例添加有藍色顏料。對照組2亦含有0.13 wt%的黃色染料,但不含藍色顏料。接著依步驟S930~S950,分別將組合物7及對照組2製成防藍光隱形眼鏡樣品7及對照組(對照組2)隱形眼鏡並觀察其外觀,結果示於圖4A~4B。In Embodiment 3, composition 7 is prepared according to step S920, and a control group (control group 2) is also prepared. The yellow dye contained in the composition 7 accounted for 0.13 wt% of its total weight, and the blue pigment was added in a ratio of 7:1 between the yellow dye and the blue pigment. Control 2 also contained 0.13 wt% of yellow dye, but did not contain blue pigment. Then, according to steps S930 to S950, the composition 7 and the control group 2 were prepared into the blue light-proof contact lens sample 7 and the control group (control group 2), respectively, and their appearance was observed. The results are shown in FIGS. 4A to 4B.
圖4A左邊為市售抗UV水藍隱形眼鏡(對照組3),右邊為防藍光隱形眼鏡(樣品7)。圖4B左邊為對照組(對照組2)隱形眼鏡,右邊為樣品7。樣品7與對照組(對照組2)隱形眼鏡之成分如前述。對照組3含抗紫外光成分,惟沒有防藍光波長的染料成分,因此呈微藍、微藍紫或微紫色澤且不帶有黃色調。如圖4A~4B所示,對照組(對照組2)隱形眼鏡明顯帶有黃色調,而在黃色染料含量相同下,樣品7呈現微綠色。The left side of Figure 4A is a commercially available anti-UV water blue contact lens (control 3), and the right side is an anti-blue light contact lens (sample 7). The left side of Fig. 4B is the contact lens of the control group (control group 2), and the right side is the sample 7. The components of the contact lenses of sample 7 and the control group (control group 2) are as described above. The control group 3 contained anti-ultraviolet components, but did not have the dye component of anti-blue wavelength, so it was bluish, bluish-violet or purple-colored, and did not have a yellowish tint. As shown in FIGS. 4A to 4B, the contact lens of the control group (control group 2) obviously has a yellowish tint, while under the same yellow dye content, the sample 7 is slightly green.
綜上所述,本發明實施例不僅具有防藍光之功效,在外觀上而言,防藍光隱形眼鏡呈現綠、藍綠或藍色調,接近人類眼白的自然顏色。防藍光隱形眼鏡的色調使其於配戴時更顯 “隱形”,還有助於避免配戴者發生視覺疲勞、避免造成視覺色差,且有助提升美觀效果。In summary, the embodiments of the present invention not only have the effect of anti-blue light, but in terms of appearance, the anti-blue light contact lens presents a green, blue-green or blue hue, which is close to the natural color of the white of human eyes. The color tone of the anti-blue light contact lens makes it more "invisible" when worn, and also helps to avoid visual fatigue of the wearer, avoid visual chromatic aberration, and help improve the aesthetic effect.
本發明還提供一種防藍光隱形眼鏡,其含有黃色染料以及藍色顏料,或包含前述組合物例如組合物1~7及/或由組合物1~7製備而得。黃色染料及藍色顏料如前所述。或者,防藍光隱形眼鏡以前述方法製備而得。因包含黃色染料,防藍光隱形眼鏡可降低在藍光波長範圍之可見光的穿透率。The present invention also provides an anti-blue light contact lens, which contains yellow dye and blue pigment, or contains the aforementioned composition, such as composition 1-7 and/or is prepared from composition 1-7. The yellow dye and blue pigment are as described above. Alternatively, the anti-blue light contact lens is prepared by the aforementioned method. Containing yellow dyes, anti-blue contact lenses can reduce the transmittance of visible light in the blue wavelength range.
在一實施例中,防藍光隱形眼鏡使波長380至460nm的藍光的穿透率小於75%,使波長於380至780 nm的光下具有大於85%的穿透率,因此允許可見光穿過,無礙配戴者視物,同時有助於減少高能光傳遞至眼睛的量。因包含藍色顏料,防藍光隱形眼鏡呈現綠、藍綠或藍色調,接近人類眼白的自然顏色,較為美觀而有助提升配戴者的使用感受。In one embodiment, the anti-blue light contact lens makes the transmittance of blue light with a wavelength of 380 to 460 nm less than 75%, and makes the transmittance of light with a wavelength of 380 to 780 nm greater than 85%, thus allowing visible light to pass through. It does not hinder the wearer's vision, and at the same time helps to reduce the amount of high-energy light transmitted to the eyes. Due to the inclusion of blue pigments, the anti-blue light contact lens presents a green, blue-green or blue hue, which is close to the natural color of the whites of human eyes. It is more beautiful and helps enhance the wearer's experience.
雖然本發明已以實施例揭露如上,然其並非用以限定本發明,本發明所屬技術領域中具有通常知識者,在不脫離本發明之精神和範圍內,當可作些許之更動與潤飾,因此本發明之保護範圍當視後附之申請專利範圍所界定者為準。Although the present invention has been disclosed in the above embodiments, it is not intended to limit the present invention. Those with ordinary knowledge in the technical field of the present invention can make some changes and modifications without departing from the spirit and scope of the present invention. Therefore, the protection scope of the present invention shall be subject to those defined by the attached patent application scope.
S910:提供模具,且模具包含公模及母模 S920:配製防藍光隱形眼鏡組合物,且組合物包含黃色染料以及藍色顏料 S930:將組合物注入母模,再將公模與母模壓合 S940:進行光固化並形成鏡片本體 S950:進行水化並形成隱形眼鏡S910: Provide molds, and molds include male and female molds S920: Formulate an anti-blue light contact lens composition, and the composition includes a yellow dye and a blue pigment S930: Inject the composition into the female mold, and then press the male mold and the female mold together S940: Light curing and forming the lens body S950: Hydrate and form contact lenses
圖1為本發明一實施例的防藍光隱形眼鏡的製備方法的流程圖。 圖2為本發明一實施例的防藍光隱形眼鏡的光波長與穿透率關係圖。 圖3為本發明一實施例的防藍光隱形眼鏡的對照組的光波長與穿透率關係圖。 圖4A~4B為本發明一實施例的防藍光隱形眼鏡與對照組的外觀示意圖。FIG. 1 is a flowchart of a method for preparing blue light-proof contact lenses according to an embodiment of the present invention. 2 is a diagram showing the relationship between the light wavelength and the transmittance of the anti-blue light contact lens according to an embodiment of the present invention. Fig. 3 is a diagram showing the relationship between light wavelength and transmittance of a control group of anti-blue contact lenses according to an embodiment of the present invention. 4A to 4B are schematic diagrams of the appearance of a blue light-proof contact lens and a control group according to an embodiment of the present invention.
Claims (17)
Priority Applications (6)
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TW109111035A TWI779275B (en) | 2020-03-31 | 2020-03-31 | Anti-blue light contact lens, composition and manufacturing method thereof |
JP2020090482A JP6902808B1 (en) | 2020-03-31 | 2020-05-25 | How to make blue light cut contact lenses |
KR1020200091187A KR20210123187A (en) | 2020-03-31 | 2020-07-22 | Bluelight cut contact lense, composition thereof and method for making the same |
CN202010725262.XA CN113462019A (en) | 2020-03-31 | 2020-07-24 | Blue light-proof contact lens, composition and manufacturing method thereof |
JP2021032308A JP2021161386A (en) | 2020-03-31 | 2021-03-02 | Blue light cutting contact lens, and composition of the same |
KR1020230088999A KR20230108250A (en) | 2020-03-31 | 2023-07-10 | Bluelight cut contact lense, composition thereof and method for making the same |
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TW109111035A TWI779275B (en) | 2020-03-31 | 2020-03-31 | Anti-blue light contact lens, composition and manufacturing method thereof |
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TWI779275B TWI779275B (en) | 2022-10-01 |
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US11724471B2 (en) | 2019-03-28 | 2023-08-15 | Johnson & Johnson Vision Care, Inc. | Methods for the manufacture of photoabsorbing contact lenses and photoabsorbing contact lenses produced thereby |
US11724472B2 (en) | 2010-04-13 | 2023-08-15 | Johnson & Johnson Vision Care, Inc. | Process for manufacture of a thermochromic contact lens material |
US11789291B2 (en) | 2010-04-13 | 2023-10-17 | Johnson & Johnson Vision Care, Inc. | Pupil-only photochromic contact lenses displaying desirable optics and comfort |
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WO2024077508A1 (en) * | 2022-10-12 | 2024-04-18 | 晶硕光学股份有限公司 | Blue light blocking contact lenses and preparation method therefor |
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- 2020-05-25 JP JP2020090482A patent/JP6902808B1/en active Active
- 2020-07-22 KR KR1020200091187A patent/KR20210123187A/en not_active Application Discontinuation
- 2020-07-24 CN CN202010725262.XA patent/CN113462019A/en active Pending
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2021
- 2021-03-02 JP JP2021032308A patent/JP2021161386A/en not_active Withdrawn
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US11724472B2 (en) | 2010-04-13 | 2023-08-15 | Johnson & Johnson Vision Care, Inc. | Process for manufacture of a thermochromic contact lens material |
US11789291B2 (en) | 2010-04-13 | 2023-10-17 | Johnson & Johnson Vision Care, Inc. | Pupil-only photochromic contact lenses displaying desirable optics and comfort |
US11724471B2 (en) | 2019-03-28 | 2023-08-15 | Johnson & Johnson Vision Care, Inc. | Methods for the manufacture of photoabsorbing contact lenses and photoabsorbing contact lenses produced thereby |
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Publication number | Publication date |
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CN113462019A (en) | 2021-10-01 |
JP2021161386A (en) | 2021-10-11 |
KR20230108250A (en) | 2023-07-18 |
KR20210123187A (en) | 2021-10-13 |
JP2021162833A (en) | 2021-10-11 |
TWI779275B (en) | 2022-10-01 |
JP6902808B1 (en) | 2021-07-14 |
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