TW202123962A - 一種預防和治療腎纖維化的方法 - Google Patents

一種預防和治療腎纖維化的方法 Download PDF

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Publication number
TW202123962A
TW202123962A TW110102361A TW110102361A TW202123962A TW 202123962 A TW202123962 A TW 202123962A TW 110102361 A TW110102361 A TW 110102361A TW 110102361 A TW110102361 A TW 110102361A TW 202123962 A TW202123962 A TW 202123962A
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Taiwan
Prior art keywords
plasminogen
fibrosis
renal
mice
group
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TW110102361A
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English (en)
Chinese (zh)
Inventor
李季男
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大陸商深圳瑞健生命科學研究院有限公司
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Publication of TW202123962A publication Critical patent/TW202123962A/zh

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/243Platinum; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482Serine endopeptidases (3.4.21)
    • A61K38/484Plasmin (3.4.21.7)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21007Plasmin (3.4.21.7), i.e. fibrinolysin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW110102361A 2016-12-15 2017-06-19 一種預防和治療腎纖維化的方法 TW202123962A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
WOPCT/CN2016/110174 2016-12-15
WOPCT/CN2016/110169 2016-12-15
CN2016110169 2016-12-15
CN2016110174 2016-12-15

Publications (1)

Publication Number Publication Date
TW202123962A true TW202123962A (zh) 2021-07-01

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Application Number Title Priority Date Filing Date
TW110102361A TW202123962A (zh) 2016-12-15 2017-06-19 一種預防和治療腎纖維化的方法
TW106120455A TW201822797A (zh) 2016-12-15 2017-06-19 一種預防和治療腎纖維化的方法
TW106120521A TWI642441B (zh) 2016-12-15 2017-06-20 一種預防和治療藥物性腎損傷的方法
TW106120523A TWI661838B (zh) 2016-12-15 2017-06-20 一種預防和治療病理性腎組織損傷的方法

Family Applications After (3)

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TW106120455A TW201822797A (zh) 2016-12-15 2017-06-19 一種預防和治療腎纖維化的方法
TW106120521A TWI642441B (zh) 2016-12-15 2017-06-20 一種預防和治療藥物性腎損傷的方法
TW106120523A TWI661838B (zh) 2016-12-15 2017-06-20 一種預防和治療病理性腎組織損傷的方法

Country Status (7)

Country Link
US (2) US20190343930A1 (https=)
EP (2) EP3556386A4 (https=)
JP (2) JP7182793B2 (https=)
CN (2) CN110167582A (https=)
CA (2) CA3047171A1 (https=)
TW (4) TW202123962A (https=)
WO (3) WO2018107699A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11154595B2 (en) 2016-12-15 2021-10-26 Talengen International Limited Method for preventing and treating pulmonary fibrosis
CA3067890A1 (en) 2017-06-19 2018-12-27 Talengen International Limited Method for regulating and controling glp-1/glp-1r and drug
TWI868051B (zh) * 2017-06-23 2025-01-01 美商波麥堤克生物治療股份有限公司 與pai-1過表現相關之病狀的纖維蛋白溶酶原治療
CN113456579B (zh) * 2021-07-12 2023-04-25 南开大学 具有双靶点的hdac抑制剂的纳米胶束-水凝胶制剂在治疗急性肾损伤药物中的应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
CN87104683A (zh) * 1986-05-15 1988-12-21 埃默里大学 改善血纤维蛋白溶解作用的组合物
CA2226575C (en) 1995-07-27 2011-10-18 Genentech, Inc. Stabile isotonic lyophilized protein formulation
US7202066B2 (en) 2002-01-29 2007-04-10 Carrington Laboratories, Inc. Combination of a growth factor and a protease enzyme
AU2003210137A1 (en) * 2002-02-06 2003-09-02 N-Zyme Biotec Gmbh Method for producing recombinant proteins in micro-organisms
EP1509236A4 (en) * 2002-05-13 2008-07-30 Children S Hospital Los Angele TREATMENT AND PREVENTION OF ABNORMAL SCALING IN KELOIDS AND OTHER SKIN OR INTERNAL WOUNDS OR LESIONS
BR0316583A (pt) * 2002-12-10 2005-10-04 Wyeth Corp Derivados de ácido acético 3-alquil e 3-arilalquil 1h-indol-1-il substituìdo como inibidores do inibidor-1 do ativador do plasminogênio (pai-1)
US20050250694A1 (en) * 2003-10-10 2005-11-10 Ma Jian-Xing Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same
JP2008510814A (ja) * 2004-08-23 2008-04-10 ワイス Pai−1阻害剤としてのピロロ−ナフチル酸
US8741260B2 (en) 2005-10-07 2014-06-03 Armagen Technologies, Inc. Fusion proteins for delivery of GDNF to the CNS
AU2007290881B2 (en) * 2006-08-28 2013-03-07 Omnio Healer Ab Candidates against infection
ES2516717T3 (es) * 2009-05-26 2014-10-31 Universidad De Salamanca Proteína activadora de GM2 en orina como marcador de fallo renal agudo o de riesgo de desarrollar fallo renal agudo
WO2011004011A1 (en) * 2009-07-10 2011-01-13 Thrombogenics Nv Variants of plasminogen and plasmin
CN102121023B (zh) * 2010-12-22 2012-07-04 中山大学 突变型人纤溶酶原kringle5及其制备方法及应用
JP6085568B2 (ja) * 2011-01-05 2017-02-22 スロンボジェニックス・ナムローゼ・フェンノートシャップThromboGenics NV プラスミノーゲンおよびプラスミンの変異体
CN102154253A (zh) 2011-01-06 2011-08-17 郑州大学 具有抑制血小板凝集功能的微小纤溶酶原突变体及其制备方法和用途
AU2012315586B2 (en) * 2011-09-29 2017-07-20 Mayo Foundation For Medical Education And Research Aromatic-cationic peptides and methods for using same
TN2016000048A1 (en) * 2013-08-13 2017-07-05 Sanofi Sa Antibodies to plasminogen activator inhibitor-1 (pai-1) and uses thereof
CA2939897A1 (en) * 2014-02-21 2015-08-27 Astellas Pharma Inc. New anti-human pai-1 antibody

Also Published As

Publication number Publication date
TWI661838B (zh) 2019-06-11
WO2018107695A1 (zh) 2018-06-21
JP7242057B2 (ja) 2023-03-20
CN110366427A (zh) 2019-10-22
CN110167582A (zh) 2019-08-23
JP2020502135A (ja) 2020-01-23
TW201822793A (zh) 2018-07-01
EP3556388A1 (en) 2019-10-23
WO2018107700A1 (zh) 2018-06-21
JP2020502134A (ja) 2020-01-23
TW201822794A (zh) 2018-07-01
JP7182793B2 (ja) 2022-12-05
CA3047170A1 (en) 2018-06-21
CA3047171A1 (en) 2018-06-21
EP3556386A4 (en) 2020-07-08
US20190328848A1 (en) 2019-10-31
EP3556386A1 (en) 2019-10-23
TWI642441B (zh) 2018-12-01
WO2018107699A1 (zh) 2018-06-21
TW201822797A (zh) 2018-07-01
EP3556388A4 (en) 2020-07-08
US20190343930A1 (en) 2019-11-14

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