TW202120104A - 用於治療apoc3相關疾病及病症之方法 - Google Patents

用於治療apoc3相關疾病及病症之方法 Download PDF

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TW202120104A
TW202120104A TW109126581A TW109126581A TW202120104A TW 202120104 A TW202120104 A TW 202120104A TW 109126581 A TW109126581 A TW 109126581A TW 109126581 A TW109126581 A TW 109126581A TW 202120104 A TW202120104 A TW 202120104A
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Taiwan
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dose
pharmaceutical composition
apoc3
apoc3 rnai
administered
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TW109126581A
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English (en)
Chinese (zh)
Inventor
布魯斯 齊文
詹姆士 Ｃ 漢彌頓
史黛西 梅爾柯斯特
李
銳 朱
濤 裴
史蒂芬 坎納
素珍 黃
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美商愛羅海德製藥公司
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Publication of TW202120104A publication Critical patent/TW202120104A/zh

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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
TW109126581A 2019-08-05 2020-08-05 用於治療apoc3相關疾病及病症之方法 TW202120104A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201962883046P 2019-08-05 2019-08-05
US62/883,046 2019-08-05
US201962936559P 2019-11-17 2019-11-17
US62/936,559 2019-11-17
US202062970613P 2020-02-05 2020-02-05
US62/970,613 2020-02-05

Publications (1)

Publication Number Publication Date
TW202120104A true TW202120104A (zh) 2021-06-01

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TW109126581A TW202120104A (zh) 2019-08-05 2020-08-05 用於治療apoc3相關疾病及病症之方法

Country Status (10)

Country Link
US (1) US20220152079A1 (OSRAM)
EP (1) EP4010075A4 (OSRAM)
JP (2) JP7829478B2 (OSRAM)
KR (1) KR20220044551A (OSRAM)
CN (1) CN114555188A (OSRAM)
AU (1) AU2020324974B2 (OSRAM)
CA (1) CA3147725A1 (OSRAM)
MX (1) MX2022001460A (OSRAM)
TW (1) TW202120104A (OSRAM)
WO (1) WO2021026150A1 (OSRAM)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6989521B2 (ja) * 2016-09-02 2022-01-05 アローヘッド ファーマシューティカルズ インコーポレイテッド 標的化リガンド
CN114934074A (zh) * 2022-06-01 2022-08-23 北京大学 一种ApoC3基因敲除仓鼠模型的构建方法
EP4706646A1 (en) 2023-06-01 2026-03-11 Sunshine Lake Pharma Co., Ltd. Novel double-stranded sirna, conjugate thereof, and use thereof
KR20260032888A (ko) * 2024-08-30 2026-03-10 올릭스 주식회사 APOC3 유전자를 표적으로 하는 RNAi 제제 및 이의 용도

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2768091T3 (es) * 2009-02-10 2020-06-19 Amarin Pharmaceuticals Ie Ltd Uso del éster etílico del ácido eicosapentaenoico para tratar la hipertrigliceridemia
EP3444348A1 (en) 2011-06-21 2019-02-20 Alnylam Pharmaceuticals, Inc. Angiopoietin-like 3 (angptl3) irna compositions and methods of use thereof
KR20230084331A (ko) * 2011-06-21 2023-06-12 알닐람 파마슈티칼스 인코포레이티드 아포리포단백질 c-iii(apoc3) 유전자의 발현 억제를 위한 조성물 및 방법
CA2968114A1 (en) * 2014-11-17 2016-05-26 Alnylam Pharmaceuticals, Inc. Apolipoprotein c3 (apoc3) irna compositions and methods of use thereof
AU2017376950B2 (en) * 2016-12-16 2024-02-22 Alnylam Pharmaceuticals, Inc. Methods for treating or preventing TTR-associated diseases using transthyretin (TTR) iRNA compositions
EP3630788A4 (en) 2017-06-02 2021-04-28 Wave Life Sciences Ltd. OLIGONUCLEOTIDE COMPOSITIONS AND METHODS FOR THEIR USE
TN2020000039A1 (en) * 2017-09-11 2021-10-04 Arrowhead Pharmaceuticals Inc Rnai agents and compositions for inhibiting expression of apolipoprotein c-iii (apoc3)
US11660347B2 (en) * 2017-12-01 2023-05-30 Suzhou Ribo Life Science Co., Ltd. Nucleic acid, composition and conjugate containing same, preparation method, and use thereof

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Publication number Publication date
WO2021026150A1 (en) 2021-02-11
AU2020324974B2 (en) 2026-04-30
JP7829478B2 (ja) 2026-03-13
EP4010075A1 (en) 2022-06-15
US20220152079A1 (en) 2022-05-19
CN114555188A (zh) 2022-05-27
KR20220044551A (ko) 2022-04-08
JP2025061882A (ja) 2025-04-11
JP2022543136A (ja) 2022-10-07
CA3147725A1 (en) 2021-02-11
EP4010075A4 (en) 2023-11-15
MX2022001460A (es) 2022-02-22
AU2020324974A1 (en) 2022-02-24

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