TW202115249A - 用於定序反應之聚合酶 - Google Patents

用於定序反應之聚合酶 Download PDF

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TW202115249A
TW202115249A TW109121907A TW109121907A TW202115249A TW 202115249 A TW202115249 A TW 202115249A TW 109121907 A TW109121907 A TW 109121907A TW 109121907 A TW109121907 A TW 109121907A TW 202115249 A TW202115249 A TW 202115249A
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布萊恩 瑞德
曼朱拉 潘迪
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Abstract

本發明提供包含經修飾重組聚合酶之組合物以及編碼該等經修飾聚合酶之核酸分子。在一些態樣中,提供使用此類聚合酶合成核酸分子或定序核酸模板之方法。

Description

用於定序反應之聚合酶
DNA聚合酶係所有活生物體之基因體複製所必需之核苷酸聚合酶。除其在複製及修復期間保持基因體完整性方面之作用之外,DNA聚合酶亦廣泛用於活體外DNA操控,包括DNA選殖、誘變及定序。DNA聚合酶根據模板DNA合成互補股之基本能力係保守的,儘管特定特性,包括持續效力、保真性及受質核苷酸選擇性在不同酶中有所不同。
本文中所揭示之技術之態樣係關於可用於進行活體外聚合反應之經修飾聚合酶(polymerizing enzymes)(例如聚合酶(polymerases))。在一些態樣中,本文中所描述之聚合酶適合用於定序反應(例如核酸定序)。在一些態樣中,本發明提供具有一或多個修飾之重組聚合酶。在一些實施例中,本發明之重組聚合酶包含胺基酸突變或域取代中之至少一者。
在一些態樣中,本發明提供具有基於天然存在聚合酶(例如選自表1)且包括一或多個胺基酸突變及/或區段取代之胺基酸序列的經修飾聚合酶(例如核酸聚合酶(nucleic acid polymerizing enzyme/nucleic acid polymerase))。在一些實施例中,經修飾聚合酶具有基於屎腸球菌(E. faecium )聚合酶(SEQ ID No: 2-5)之胺基酸序列。在一些實施例中,經修飾聚合酶具有基於SEQ ID NO: 23-33之胺基酸序列。在一些實施例中,經修飾聚合酶包含一或多個區段取代(例如其中聚合酶之一或多個區段經一或多個來自不同聚合酶之對應的區段置換)、一或多個胺基酸添加、缺失及/或取代或其組合。在一些實施例中,區段包含聚合酶之定義區域(例如結構性或功能性域或子域)或其部分,且視情況包括一或多個側接胺基酸(例如,在表1之天然存在聚合酶中,例如,在胺基酸區域或部分之任一側上之1-50、1-40、1-30、1-20、1-10、1-5、5-10、5-25或此等範圍內,例如SEQ ID No: 2-5或SEQ ID No: 23-33之任何整數個胺基酸)。在一些實施例中,一或多個胺基酸插入、缺失或取代對應於兩個天然存在聚合酶之間在一或多個位置處的天然存在之差異。在一些實施例中,一或多個胺基酸插入、缺失或取代係新的非天然存在之變化。在一些實施例中,胺基酸取代係保守胺基酸取代(例如用一種具有相似特性,例如具有相似帶電、極性、疏水性、親水性及/或其他相似特性(諸如相似大小)之胺基酸置換另一種胺基酸)。在一些實施例中,胺基酸取代係非保守胺基酸取代。在一些實施例中,一或多個胺基酸插入、缺失或取代可在經修飾聚合酶中之任何位置,包括在來自不同聚合酶之一或多個交換區段中及/或在原始聚合酶之區段中。
相應地,在一些實施例中本發明提供滿足以下條件之重組聚合酶:具有選自表1之胺基酸序列,例如SEQ ID NO: 2-5或SEQ ID NO: 23-33 (或具有擁有與選自表1之胺基酸序列,例如SEQ ID NO: 2-5或SEQ ID NO: 23-33之胺基酸序列至少50%、至少60%、至少70%、至少80%、80-90%、90-95%、95-99%或更高之胺基酸序列一致性的胺基酸序列),且包含一或多個來自表2、表3、表4、表5、表6或表7之胺基酸修飾。在一些實施例中,一或多個胺基酸修飾包括至少一個胺基酸突變(例如1、2、3、4、5、6、7、8、9、10、15、20、25或更多個胺基酸突變)。在一些實施例中,一或多個胺基酸修飾包括至少1個且至多5個胺基酸突變、至少1個且至多10個胺基酸突變、至少1個且至多15個胺基酸突變、至少1個且至多25個胺基酸突變、至少1個且至多50個胺基酸突變、或至少1個且至多100個胺基酸突變。在一些實施例中,一或多個胺基酸修飾包括至少一個域取代(例如全部域之取代或包涵域或一部分域之區段之取代)。在一些實施例中,至少一個域取代包含外切核酸酶域取代及聚合酶域取代中之至少一者。在一些實施例中,外切核酸酶域取代包含外切核酸酶環取代。在一些實施例中,聚合酶域取代包含掌型子域取代、TPR1子域取代、手指型子域取代、TPR2子域取代或拇指型子域取代中之任一者(例如全部聚合酶、掌型、TPR1、手指型、TPR2或拇指型域或子域或其中任一者之部分,視情況包括一或多個側接胺基酸的取代)。在一些實施例中,一或多個胺基酸修飾包括至少一個域取代及至少一個胺基酸突變。在一些實施例中,胺基酸突變可為胺基酸嵌入、缺失或取代。
在一些實施例中,本發明之重組聚合酶具有選自表2之序列。在一些實施例中,本發明提供具有選自表3之序列的重組聚合酶。在一些實施例中,本發明提供具有選自表4之序列的重組聚合酶。在一些實施例中,本發明提供具有表7中所列之修飾之組合的重組聚合酶。
在一些態樣中,本發明提供包含以下區段之重組聚合酶,該區段包括表1中之重組聚合酶(例如SEQ ID NO: 2-5或SEQ ID NO: 23-33)中之任一者之外切核酸酶區域或其部分(及視情況,位於一側或兩側上之側接胺基酸)。在一些態樣中,本發明提供包含以下區段之重組聚合酶,該區段包括表1中之重組聚合酶(例如SEQ ID NO: 2-5或SEQ ID NO: 23-33)中之任一者的掌型區域或其部分(及視情況,位於一側或兩側上之側接胺基酸)。在一些態樣中,本發明提供包含以下區段之重組聚合酶,該區段包括表1中之重組聚合酶(例如SEQ ID NO: 2-5或SEQ ID NO: 23-33)中之任一者的TPR1區域或其部分(及視情況,位於一側或兩側上之側接胺基酸)。在一些態樣中,本發明提供包含以下區段之重組聚合酶,該區段包括表1中之重組聚合酶(例如SEQ ID NO: 2-5或SEQ ID NO: 23-33)中之任一者的手指型區域或其部分(及視情況,位於一側或兩側上之側接胺基酸)。在一些態樣中,本發明提供包含以下區段之重組聚合酶,該區段包括表1中之重組聚合酶(例如SEQ ID NO: 2-5或SEQ ID NO: 23-33)中之任一者之TPR2區域或其部分(及視情況,位於一側或兩側上之側接胺基酸)。在一些態樣中,本發明提供包含以下區段之重組聚合酶,該區段包括表1中之重組聚合酶(例如SEQ ID NO: 2-5或SEQ ID NO: 23-33)中之任一者的拇指型區域或其部分(及視情況,位於一側或兩側上之側接胺基酸)。在一些態樣中,本發明提供包含兩個或更多個如本文中所描述之區段的重組聚合酶。
相應地,在一些實施例中,重組聚合酶為包含一或多個來自不同聚合酶(例如來自不同物種)之胺基酸區段的嵌合酶。在一些實施例中,嵌合聚合酶包含來自第一聚合酶之胺基酸序列,其中一或多個區段已經來自不同聚合酶之區段置換。在一些實施例中,一或多個來自不同聚合酶之區段可為包含來自M2Y聚合酶之胺基酸1-51的區段、包含來自屎腸球菌(E. faecium )聚合酶之胺基酸271-375的區段、包含來自屎腸球菌聚合酶之胺基酸72-89的區段及/或包含來自屎腸球菌聚合酶之胺基酸445-449的區段。在一些實施例中,來自M2Y聚合酶之1-51區段置換對應的天然存在聚合酶區段(例如Φ29聚合酶之胺基酸1-54)。在一些實施例中,來自屎腸球菌聚合酶之271-375區段置換對應的天然存在聚合酶區段(例如Φ29聚合酶之胺基酸260-359)。在一些實施例中,來自屎腸球菌聚合酶之72-89區段置換對應的天然存在聚合酶區段(例如Φ29聚合酶之胺基酸75-91)。在一些實施例中,來自屎腸球菌聚合酶之445-449區段置換對應的天然存在聚合酶區段(例如Φ29聚合酶之胺基酸429-433)。
在一些實施例中,重組聚合酶包含一或多個對應於Φ29中之以下取代的取代:M8R、V51A、N62D、I71V、L107I、K131E、K135Q、L142K、G197D、Y224K、E239G、V250A/I、L253A/H、Y281H、I288L、T301C、R306Q、R308L、D325E、D341E、K354R、T368F、E375Y、A437G、A444T、E466K、D476H、A484E、E508R、D510K/R、K512Y、E515Q、K539E、D570S及T571V。
在一些實施例中,重組聚合酶包含一或多個對應於屎腸球菌中之以下取代的取代:K4R、S22A、N59D、E60L、E85P、N106G、Q122V、P136T、E139K/Q、E142K/Q、I148K、D167P、D171K、D189K、T211A、D232K、V261A/I、L264A/H/M、T479V、E482K、D492H、S493P、K500E、Q513D、E519R、D521K/R、E523K/Y、R308G、S319L、L320M、E323V、D337G、E338K、D341T、I384F/S、E391Y/W/F/H/M/K/R、L437Y、E537K、T568S及M569V。
在一些實施例中,經修飾聚合酶包含一或多個本文中所描述之區段取代及/或胺基酸插入、缺失及/或取代,且亦包含一或多個(例如1-5、5-10、10-25、25-50、50-75、75-100、100-125、125-150個)額外胺基酸插入、缺失及/或取代(例如保守或非保守胺基酸取代)。相應地,在一些實施例中,表2、表3或表4之經修飾聚合酶可包括額外一或多個(例如1-5、5-10、10-25、25-50、50-75、75-100、100-125、125-150個)額外胺基酸插入、缺失及/或取代(例如保守或非保守胺基酸取代)。
在一些態樣中,本發明係關於包含第一區段及第二區段之經修飾重組酶,其中:一種經修飾重組酶,其包括第一區段及第二區段,其中:該第一區段包含對應於第一參考區段之胺基酸序列,該第一參考區段含有SEQ ID NO: 2之胺基酸197-271,其中該第一區段之胺基酸序列與該第一參考區段之胺基酸序列至少80%、80-90%、90-95%或至少95%一致,且其中該第一區段具有高於該第一參考區段之等電點;及該第二區段包含對應於第二參考區段之胺基酸序列,該第二參考區段含有SEQ ID NO: 2之胺基酸443-528,其中該第二區段之胺基酸序列與該第二參考區段之胺基酸序列至少80%、80-90%、90-95%或至少95%一致,且其中該第二區段具有高於該第二參考區段之等電點。在特定實施例中,第一區段包含與SEQ ID NO: 2之197-271至少80%、80-90%、90-95%或至少95%一致之胺基酸序列,且第二區段包含與SEQ ID NO: 2之胺基酸443-528至少80%、80-90%、90-95%或至少95%一致之胺基酸序列。
在一些態樣中,本發明係關於經修飾重組酶,其包含:包含對應於參考區段之胺基酸序列的第一區段,該參考區段含有SEQ ID NO: 2之胺基酸1-196,其中第一區段之胺基酸序列與參考區段之胺基酸序列至少80%、80-90%、90-95%或至少95%一致;且其中第一區段具有高於參考區段之等電點。在特定實施例中,第一區段包含與SEQ ID NO: 2之1-196至少80%、80-90%、90-95%或至少95%一致之胺基酸序列。
在一些態樣中,本發明係關於包含第一區段及第二區段之經修飾重組酶,其中:第一區段包含對應於第一參考區段之胺基酸序列,該第一參考區段含有SEQ ID NO: 2之胺基酸1-271,其中該第一區段之胺基酸序列與該第一參考區段之胺基酸序列至少80%、80-90%、90-95%或至少95%一致,且其中該第一區段具有高於該第一參考區段之等電點;及該第二區段包含對應於第二參考區段之胺基酸序列,該第二參考區段含有SEQ ID NO: 2之胺基酸443-528,其中該第二區段之胺基酸序列與該第二參考區段之胺基酸序列至少80%、80-90%、90-95%或至少95%一致,且其中該第二區段具有高於該第二參考區段之等電點。在特定實施例中,第一區段包含與SEQ ID NO: 2之1-271至少80%、80-90%、90-95%或至少95%一致之胺基酸序列,且第二區段包含與SEQ ID NO: 2之胺基酸443-528至少80%、80-90%、90-95%或至少95%一致之胺基酸序列。
在一些實施例中,經修飾重組酶之胺基酸序列包含對應於以下之一或多個位置處之修飾:SEQ ID NO: 2之K4、T13、S22、V25、C26、D27、N33、I34、F36、S42、D54、N59、E60、E65、E85、M95、N106、T110、T114、K119、Q122、Y133、P136、E139、E142、N145、P147、I148、E152、I153、P160、D167、D171、N175、F188、D189、Q206、T211、S216、R217、D232、A236、V247、I253、V261、L264、S267、V443、L445、A446、S447、V449、T450、W452、G453、Y455、F465、N467、T479、E482、A484、E485、A486、L490、D492、S493、K495、K500、S503、Q506、Q513、E519、D521、E523及V526。在一些實施例中,修飾為選自由以下組成之群的胺基酸取代:K4R、T13N、S22A、V25L、C26W、D27E、N33T、I34V、F36V、S42T、D54Y、N59D、E60L、E60V、E65S、E85P、M95T、M95K、N106G、T110I、T114S、K119Q、Q122V、Y133L、P136T、E139K、E139Q、E139R、E139H、E142K、E142Q、E142R、E142H、N145K、N145H、N145R、P147Q、P147T、I148K、I148H、I148R、E152D、I153V、P160A、D167P、D167K、D167H、D167R、D171K、D171H、D171R、N175T、N175Y、F188C、D189K、D189H、D189R、Q206R、Q206K、Q206H、T211A、S216G、S216R、R217G、D232K、A236G、V247D、I253H、I253A、V261A、V261I、V261L、L264H、L264A、L264M、S267A、V443T、L445M、A446G、S447V、V449I、T450A、W452Y、G453A、Y455W、F465Y、N467R、N467K、N467H、N467S、N467T、T479V、E482K、E482H、E482R、A484E、E485D、A486E、L490M、D492H、D492K、D492R、D492A、H492S、S493P、K495R、K500E、S503A、S503T、Q506K、Q513D、D521K、D521R、D521H、E523R、E523V、E523Y、E523F、E523H、E523W及V526L。
在一些實施例中,經修飾重組酶之胺基酸序列包含對應於以下之一或多個位置處之修飾:E139、E142、N145、I148、D167、D171、D189、N467、E482、D492、K495、D521及E523。在一些實施例中,修飾為選自由以下組成之群的胺基酸取代:E139K、E139Q、E139R、E139H、E142K、E142H、E142R、E142Q、N145K、N145H、N145R、I148K、I148H、I148R、D167P、D167K、D167H、D167R、D171K、D171H、D171R、D189K、D189H、D189R、N467R、N467K、N467H、N467S、N467T、E482K、E482H、E482R、D492H、D492K、D492R、K495R、D521K、D521H、D521R、E523K、E523Y、E523H、E523R、E523F及E523W。
在一些實施例中,經修飾重組酶之胺基酸序列包含對應於以下之一或多個位置處之修飾:SEQ ID NO: 2之P273、P275、R308、V315、Q317、S319、L320、I322、Q323、D337、E338、D341、T345、F352、F353、T364、D374、I384、E385、N388、E391、A396、N397、G400、D414、D425、R429、E436、L437、D533、R534、E537、G547、E545、L555、P556、R558、T559、V564、T568、M569及T571。在一些實施例中,修飾為選自由以下組成之群的胺基酸取代:P273S、P273R、P275S、E283K、V315L、S319R、R308G、G308R、Q317R、S319R、L320M、L320T、I322K、Q323G、Q323V、Q323R、D337G、E338K、D341T、T345I、F352I、F353C、T364I、D374G、D374Q、D374H、I384T、I384F、I384S、E385Y、E385K、E385R、E385N、E385Q、E385L、E385A、N388T、E391Y、E391W、E391F、E391H、E391M、E391K、E391R、A396Q、N397L、G400L、D414V、D425N、R429G、E436R、E436G、L437Y、L437E、D533A、D533Q、D533T、D533R、D533S、R534K、E537K、E537H、E537R、E545K、E545H、E545R、G547S、L555K、L555R、P556A、R558H、T559V、V564L、T568D、T568S、M569K、M569T、M569V及T571S。在一些實施例中,修飾為選自由以下組成之群的胺基酸取代:D374G、D374Q、D374H、E385Y、E385K、E385R、E385N、E385Q、E385L、E385A、E391Y、E391W、E391K、E391F、D533A、D533Q、D533T、D533R、D533S、E537K、E537H、E537R、E545K、E545H及E545R。
在一些實施例中,經修飾重組酶包含表7中所列之修飾之組合。
在一些實施例中,經修飾重組酶之胺基酸序列包含對應於E142、I148、D189、V261、L264、R308、E391、E482、D492、K500、D521、E523及E537之位置處之修飾。在一些實施例中,位置E142處之修飾為E142K;位置I148處之修飾為I148K;位置D189處之修飾為D189K;位置V261處之修飾為V261A;位置L264處之修飾為L264H;位置R308處之修飾為R308G;位置E391處之修飾為E391Y;位置E482處之修飾為E482K;位置D492之修飾為D492H;位置K500處之修飾為K500E;位置D521處之修飾為D521K;位置E523處之修飾為E523K;及位置E537處之修飾為E537K。在一些實施例中,經修飾重組酶包含SEQ ID NO: 88之胺基酸序列。
在一些實施例中,經修飾重組酶之胺基酸序列包含位置E60處之修飾。在一些實施例中,E60處之修飾為E60L。在一些實施例中,經修飾重組酶包含SEQ ID NO: 157之胺基酸序列。
在一些實施例中,經修飾重組酶進一步包含雙生物素標籤。
在一些實施例中,經修飾重組酶包含SEQ ID NO: 180之胺基酸序列。
在一些態樣中,本發明係關於包含一或多個選自以下之區段的經修飾重組酶:具有與SEQ ID NO: 2之胺基酸1-196至少80%、80-90%、90-95%或至少95%一致之胺基酸序列的第一區段,其中該第一區段之胺基酸序列包含對應於以下之一或多個位置處之修飾:SEQ ID NO: 2之K4、T13、S22、V25、C26、D27、N33、I34、F36、S42、D54、N59、E60、E65、E85、M95、N106、T110、T114、K119、Q122、Y133、P136、E139、E142、N145、P147、I148、E152、I153、P160、D167、D171、N175、F188及D189;具有與SEQ ID NO: 2之胺基酸197-271至少80%、80-90%、90-95%或至少95%一致之胺基酸序列的第二區段,其中該第二區段之胺基酸序列包含對應於以下之一或多個位置處之修飾:SEQ ID NO: 2之Q206、T211、S216、R217、D232、A236、V247、I253、V261、L264及S267;及/或具有與SEQ ID NO: 2之胺基酸443-528至少80%、80-90%、90-95%或至少95%一致之胺基酸序列的第三區段,其中該第三區段之胺基酸序列包含對應於以下之一或多個位置處之修飾:SEQ ID NO: 2之V443、L445、A446、S447、V449、T450、W452、G453、Y455、F465、N467、T479、E482、A484、E485、A486、L490、D492、S493、K495、K500、S503、Q506、Q513、E519、D521、E523及V526。
在一些實施例中,經修飾重組酶包含第一區段及第二區段。在一些實施例中,經修飾重組酶包含第二區段及第三區段。在一些實施例中,經修飾重組酶包含第一區段及第三區段。在一些實施例中,經修飾重組酶包含第一區段、第二區段及第三區段。
在一些實施例中,修飾為選自由以下組成之群的胺基酸取代:K4R、T13N、S22A、V25L、C26W、D27E、N33T、I34V、F36V、S42T、D54Y、N59D、E60L、E60V、E65S、E85P、M95T、M95K、N106G、T110I、T114S、K119Q、Q122V、Y133L、P136T、E139K、E139Q、E139R、E139H、E142K、E142Q、E142R、E142H、N145K、N145H、N145R、P147Q、P147T、I148K、I148H、I148R、E152D、I153V、P160A、D167P、D167K、D167H、D167R、D171K、D171H、D171R、N175T、N175Y、F188C、D189K、D189H、D189R、Q206R、Q206K、Q206H、T211A、S216G、S216R、R217G、D232K、A236G、V247D、I253H、I253A、V261A、V261I、V261L、L264H、L264A、L264M、S267A、V443T、L445M、A446G、S447V、V449I、T450A、W452Y、G453A、Y455W、F465Y、N467R、N467K、N467H、N467S、N467T、T479V、E482K、E482H、E482R、A484E、E485D、A486E、L490M、D492H、D492K、D492R、D492A、H492S、S493P、K495R、K500E、S503A、S503T、Q506K、Q513D、D521K、D521R、D521H、E523R、E523V、E523Y、E523F、E523H、E523W及V526L。
在一些實施例中,經修飾重組酶之胺基酸序列包含對應於以下之一或多個位置處之修飾:E139、E142、N145、I148、D167、D171、D189、N467、E482、D492、K495、D521及E523。在一些實施例中,修飾為選自由以下組成之群的胺基酸取代:E139K、E139Q、E139R、E139H、E142K、E142H、E142R、E142Q、N145K、N145H、N145R、I148K、I148H、I148R、D167P、D167K、D167H、D167R、D171K、D171H、D171R、D189K、D189H、D189R、N467R、N467K、N467H、N467S、N467T、E482K、E482H、E482R、D492H、D492K、D492R、K495R、D521K、D521H、D521R、E523K、E523Y、E523H、E523R、E523F及E523W。
在一些實施例中,經修飾重組酶之胺基酸序列包含對應於以下之一或多個位置處之修飾:SEQ ID NO: 2之P273、P275、R308、V315、Q317、S319、L320、I322、Q323、D337、E338、D341、T345、F352、F353、T364、D374、I384、E385、N388、E391、A396、N397、G400、D414、D425、R429、E436、L437、D533、R534、E537、G547、E545、L555、P556、R558、T559、V564、T568、M569及T571。在一些實施例中,修飾為選自由以下組成之群的胺基酸取代:P273S、P273R、P275S、E283K、V315L、S319R、R308G、G308R、Q317R、S319R、L320M、L320T、I322K、Q323G、Q323V、Q323R、D337G、E338K、D341T、T345I、F352I、F353C、T364I、D374G、D374Q、D374H、I384T、I384F、I384S、E385Y、E385K、E385R、E385N、E385Q、E385L、E385A、N388T、E391Y、E391W、E391F、E391H、E391M、E391K、E391R、A396Q、N397L、G400L、D414V、D425N、R429G、E436R、E436G、L437Y、L437E、D533A、D533Q、D533T、D533R、D533S、R534K、E537K、E537H、E537R、E545K、E545H、E545R、G547S、L555K、L555R、P556A、R558H、T559V、V564L、T568D、T568S、M569K、M569T、M569V及T571S。在一些實施例中,修飾為選自由以下組成之群的胺基酸取代:D374G、D374Q、D374H、E385Y、E385K、E385R、E385N、E385Q、E385L、E385A、E391Y、E391W、E391K、E391F、D533A、D533Q、D533T、D533R、D533S、E537K、E537H、E537R、E545K、E545H及E545R。
在一些實施例中,經修飾重組酶包含表7中所列之修飾之組合。
在一些實施例中,經修飾重組酶之胺基酸序列包含對應於E142、I148、D189、V261、L264、R308、E391、E482、D492、K500、D521、E523及E537之位置處之修飾。在一些實施例中,位置E142處之修飾為E142K;位置I148處之修飾為I148K;位置D189處之修飾為D189K;位置V261處之修飾為V261A;位置L264處之修飾為L264H;位置R308處之修飾為R308G;位置E391處之修飾為E391Y;位置E482處之修飾為E482K;位置D492之修飾為D492H;位置K500處之修飾為K500E;位置D521處之修飾為D521K;位置E523處之修飾為E523K;及位置E537處之修飾為E537K。
在一些實施例中,經修飾重組酶包含SEQ ID NO: 88之胺基酸序列。
在一些實施例中,經修飾重組酶之胺基酸序列包含位置E60處之修飾。在一些實施例中,E60處之修飾為E60L。
在一些實施例中,經修飾重組酶包含SEQ ID NO: 157之胺基酸序列。
在一些實施例中,經修飾重組酶進一步包含雙生物素標籤。
在一些實施例中,經修飾重組酶包含SEQ ID NO: 180之胺基酸序列。
在一些態樣中,本發明係關於包含胺基酸序列之經修飾重組酶,該胺基酸序列包含:(i)第一區段、第二區段、第三區段、第四區段、第五區段、第六區段及第七區段;及(ii)在對應於SEQ ID NO: 2之E139、E142、N145、I148、D167、D171、D189、D374、E385、E391、N467、E482、D492、K495、D521、E523、D533、E537及E545之一或多個位置處之修飾;其中該第一區段包含與表1、表2或表3之聚合酶之外切核酸酶區域至少80%、80-90%、90-95%或至少95%一致的胺基酸序列;該第二區段及該第六區段共同包含與表1、表2或表3之聚合酶之掌型區域至少80%、80-90%、90-95%或至少95%一致的胺基酸序列;該第三區段包含與表1、表2或表3之聚合酶之TPR1區域至少80%、80-90%、90-95%或至少95%一致的胺基酸序列;該第四區段包含與表1、表2或表3之聚合酶之手指型區域至少80%、80-90%、90-95%或至少95%一致的胺基酸序列;該第五區段包含與表1、表2或表3之聚合酶之TPR2區域至少80%、80-90%、90-95%或至少95%一致的胺基酸序列;及該第七區段包含與表1、表2或表3之聚合酶之拇指型區域至少80%、80-90%、90-95%或至少95%一致的胺基酸序列。在特定實施例中,來自表1之聚合酶係選自SEQ ID NO: 2-5中之任一者。在一些實施例中,來自表1之聚合酶係選自SEQ ID NO: 23-33中之任一者。
在一些實施例中,修飾為選自由以下組成之群的胺基酸取代:E139K、E139Q、E139R、E139H、E142K、E142H、E142R、E142Q、N145K、N145H、N145R、I148K、I148H、I148R、D167P、D167K、D167H、D167R、D171K、D171H、D171R、D189K、D189H、D189R、D374G、D374Q、D374H、E385Y、E385K、E385R、E385N、E385Q、E385L、E385A、E391Y、E391W、E391K、E391F、N467R、N467K、N467H、N467S、N467T、E482K、E482H、E482R、D492H、D492K、D492R、K495R、D521K、D521H、D521R、E523K、E523Y、E523H、E523R、E523F、E523W、D533A、D533Q、D533T、D533R、D533S、E537K、E537H、E537R、E545K、E545H及E545R。在一些實施例中,經修飾重組酶進一步包含對應於以下之一或多個位置處之修飾:SEQ ID NO: 2之K4、T13、S22、V25、C26、D27、N33、I34、F36、S42、D54、N59、E60、E65、E85、M95、N106、T110、T114、K119、Q122、Y133、P136、P147、E152、I153、P160、N175、F188、Q206、T211、S216、R217、D232、A236、V247、I253、V261、L264、S267、P273、P275、R308、V315、Q317、S319、L320、I322、Q323、D337、E338、D341、T345、F352、F353、T364、I384、N388、A396、N397、G400、D414、D425、R429、E436、L437、V443、L445、A446、S447、V449、T450、W452、G453、Y455、F465、T479、A484、E485、A486、L490、S493、K500、S503、Q506、Q513、E519、V526、R534、G547、L555、P556、R558、T559、V564、T568、M569及T571。在一些實施例中,修飾為選自由以下組成之群的胺基酸取代:K4R、T13N、S22A、V25L、C26W、D27E、N33T、I34V、F36V、S42T、D54Y、N59D、E60L、E60V、E65S、E85P、M95T、M95K、N106G、T110I、T114S、K119Q、Q122V、Y133L、P136T、P147Q、P147T、E152D、I153V、P160A、N175T、N175Y、F188C、Q206R、Q206K、Q206H、T211A、S216G、S216R、R217G、D232K、A236G、V247D、I253H、I253A、V261A、V261I、V261L、L264H、L264A、L264M、S267A、P273S、P273R、P275S、E283K、V315L、S319R、R308G、G308R、Q317R、S319R、L320M、L320T、I322K、Q323G、Q323V、Q323R、D337G、E338K、D341T、T345I、F352I、F353C、T364I、I384T、I384F、I384S、N388T、A396Q、N397L、G400L、D414V、D425N、R429G、E436R、E436G、L437Y、L437E、V443T、L445M、A446G、S447V、V449I、T450A、W452Y、G453A、Y455W、F465Y、T479V、A484E、E485D、A486E、L490M、S493P、K500E、S503A、S503T、Q506K、Q513D、V526L、R534K、G547S、L555K、L555R、P556A、R558H、T559V、V564L、T568D、T568S、M569K、M569T、M569V及T571S。
在一些實施例中,經修飾重組酶包含表7中所列之修飾之組合。
在一些態樣中,本發明係關於經修飾重組酶,其包含:與SEQ ID NO: 2至少60%、60-70%、70-80%或至少80%一致的胺基酸序列;及延長掌型域,其中該延長掌型域包含與SEQ ID NO: 1之胺基酸505-524至少80%、80-90%、90-95%或至少95%一致之胺基酸序列。
在一些實施例中,經修飾重組酶進一步包含對應於以下之一或多個位置處之修飾:SEQ ID NO: 2之K4、T13、S22、V25、C26、D27、N33、I34、F36、S42、D54、N59、E60、E65、E85、M95、N106、T110、T114、K119、Q122、Y133、P136、E139、E142、N145、N145H、N145R、P147、I148、E152、I153、P160、D167、D171、N175、F188、D189、Q206、T211、S216、R217、D232、A236、V247、I253、V261、L264、S267、V443、L445、A446、S447、V449、T450、W452、G453、Y455、F465、N467、T479、E482、A484、E485、A486、L490、D492、S493、K495、K500、S503、Q506、Q513、E519、D521、E523及V526。在一些實施例中,修飾為選自由以下組成之群的胺基酸取代:K4R、T13N、S22A、V25L、C26W、D27E、N33T、I34V、F36V、S42T、D54Y、N59D、E60L、E60V、E65S、E85P、M95T、M95K、N106G、T110I、T114S、K119Q、Q122V、Y133L、P136T、E139K、E139Q、E139R、E139H、E142K、E142Q、E142R、E142H、N145K、N145H、N145R、P147Q、P147T、I148K、I148H、I148R、E152D、I153V、P160A、D167P、D167K、D167H、D167R、D171K、D171H、D171R、N175T、N175Y、F188C、D189K、D189H、D189R、Q206R、Q206K、Q206H、T211A、S216G、S216R、R217G、D232K、A236G、V247D、I253H、I253A、V261A、V261I、V261L、L264H、L264A、L264M、S267A、V443T、L445M、A446G、S447V、V449I、T450A、W452Y、G453A、Y455W、F465Y、N467R、N467K、N467H、N467S、N467T、T479V、E482K、E482H、E482R、A484E、E485D、A486E、L490M、D492H、D492K、D492R、D492A、H492S、S493P、K495R、K500E、S503A、S503T、Q506K、Q513D、D521K、D521R、D521H、E523R、E523V、E523Y、E523F、E523H、E523W及V526L。在一些實施例中,經修飾重組酶之胺基酸序列進一步包含對應於以下之一或多個位置處之修飾:E139、E142、N145、I148、D167、D171、D189、N467、E482、D492、K495、D521及E523。在一些實施例中,修飾為選自由以下組成之群的胺基酸取代:E139K、E139Q、E139R、E139H、E142K、E142H、E142R、E142Q、N145K、N145H、N145R、I148K、I148H、I148R、D167P、D167K、D167H、D167R、D171K、D171H、D171R、D189K、D189H、D189R、N467R、N467K、N467H、N467S、N467T、E482K、E482H、E482R、D492H、D492K、D492R、K495R、D521K、D521H、D521R、E523K、E523Y、E523H、E523R、E523F及E523W。
在一些實施例中,經修飾重組酶之胺基酸序列包含對應於以下之一或多個位置處之修飾:SEQ ID NO: 2之P273、P275、R308、V315、Q317、S319、L320、I322、Q323、D337、E338、D341、T345、F352、F353、T364、D374、I384、E385、N388、E391、A396、N397、G400、D414、D425、R429、E436、L437、D533、R534、E537、G547、E545、L555、P556、R558、T559、V564、T568、M569及T571。在一些實施例中,修飾為選自由以下組成之群的胺基酸取代:P273S、P273R、P275S、E283K、V315L、S319R、R308G、G308R、Q317R、S319R、L320M、L320T、I322K、Q323G、Q323V、Q323R、D337G、E338K、D341T、T345I、F352I、F353C、T364I、D374G、D374Q、D374H、I384T、I384F、I384S、E385Y、E385K、E385R、E385N、E385Q、E385L、E385A、N388T、E391Y、E391W、E391F、E391H、E391M、E391K、E391R、A396Q、N397L、G400L、D414V、D425N、R429G、E436R、E436G、L437Y、L437E、D533A、D533Q、D533T、D533R、D533S、R534K、E537K、E537H、E537R、E545K、E545H、E545R、G547S、L555K、L555R、P556A、R558H、T559V、V564L、T568D、T568S、M569K、M569T、M569V及T571S。在一些實施例中,修飾為選自由以下組成之群的胺基酸取代:D374G、D374Q、D374H、E385Y、E385K、E385R、E385N、E385Q、E385L、E385A、E391Y、E391W、E391K、E391F、D533A、D533Q、D533T、D533R、D533S、E537K、E537H、E537R、E545K、E545H及E545R。
在一些實施例中,經修飾重組酶包含表7中所列之修飾之組合。
在一些態樣中,本發明係關於具有與SEQ ID NO: 1-33中之任一者至少60%、60-70%、70-80%或至少80%一致之胺基酸序列的經修飾重組酶,其中該胺基酸序列包含對應於以下之一或多個位置處之修飾:屎腸球菌(E. faecium )聚合酶(SEQ ID NO: 2)之K4、T13、S22、V25、C26、D27、N33、I34、F36、S42、D54、N59、E60、E65、E85、M95、N106、T110、T114、K119、Q122、Y133、P136、E139、E142、N145、P147、I148、E152、I153、P160、D167、D171、N175、F188、D189、Q206、T211、S216、R217、D232、A236、V247、I253、V261、L264、S267、P273、P275、R308、V315、Q317、S319、L320、I322、Q323、D337、E338、D341、T345、F352、F353、T364、D374、I384、E385、N388、E391、A396、N397、G400、D414、D425、R429、E436、L437、V443、L445、A446、S447、V449、T450、W452、G453、Y455、F465、N467、T479、E482、A484、E485、A486、L490、D492、S493、K495、K500、S503、Q506、Q513、E519、D521、E523、V526、D533、R534、E537、G547、E545、L555、P556、R558、T559、V564、T568、M569及T571。在特定實施例中,經修飾重組酶具有與SEQ ID NO: 2-5中之任一者至少60%、60-70%、70-80%或至少80%一致之胺基酸序列且包含上述位置中之一或多者處之修飾。在一個特定實施例中,經修飾重組酶為具有與SEQ ID NO: 2中之任一者至少60%、60-70%、70-80%或至少80%一致之胺基酸序列的經修飾屎腸球菌聚合酶,且包含上述位置中之一或多者處之修飾。在一個特定實施例中,經修飾重組酶為包含SEQ ID NO: 2之胺基酸序列的經修飾屎腸球菌聚合酶,且包含該等位置中之一或多者處之修飾。在一些實施例中,經修飾重組酶具有與SEQ ID NO: 23-33中之任一者60%、60-70%、70-80%或至少80%一致之胺基酸序列,且包含上述位置中之一或多者處之修飾。
在一些實施例中,經修飾重組酶包含對應於SEQ ID NO: 2之T568及M569的一個或兩個位置處之修飾。在一些實施例中,修飾為選自由以下組成之群的胺基酸取代:T568D、T568S、M569T及M569V。在一些實施例中,經修飾重組酶相對於屎腸球菌聚合酶(SEQ ID NO: 2)具有改良之持續效力。
在一些實施例中,經修飾重組酶包含對應於SEQ ID NO: 2之N59的位置處之修飾。在一些實施例中,修飾為N59D。在一些實施例中,經修飾重組酶相對於屎腸球菌聚合酶(SEQ ID NO: 2)具有改變之外切核酸酶活性。
在一些實施例中,經修飾重組酶包含對應於以下之一或多個位置處之修飾:SEQ ID NO: 2之V261、L264、S267、I384、E391、W452、G453、Y455、D492及K500。在一些實施例中,修飾為選自由以下組成之群的胺基酸取代:V261A、V261I、L264A、L264H、L264M、S267A、I384F、I384S、E391Y、E391W、E391F、E391H、E391M、E391K、E391R、W452Y、G453A、Y455W、D492H及K500E。在一些實施例中,經修飾重組酶相對於屎腸球菌聚合酶(SEQ ID NO: 2)具有改良之核苷酸受質利用率。
在一些實施例中,經修飾重組酶包含對應於以下之一或多個位置處之修飾:SEQ ID NO: 2之E65、Y133、V261、L264、S267、I384、E391、G400、V443、L445、A446、S447、V449、T450、W452、G453、Y455、K500、S503、E523、L555及P556。在一些實施例中,修飾為選自由以下組成之群的胺基酸取代:E65S、Y133L、V261A、V261I、L264A、L264H、S267A、I384F、I384S、E391Y、E391W、E391F、E391K、G400L、V443T、L445M、A446G、S447V、V449I、T450A、W452Y、G453A、Y455W、K500E、S503A、E523K、E523Y、E523F、E523H、E523W、L555K及P556A。在一些實施例中,經修飾重組酶相對於屎腸球菌聚合酶(SEQ ID NO: 2)具有改良之精確度。
在一些實施例中,經修飾重組酶包含一或多個對應於SEQ ID NO: 2之Q317、S319、I322、Q323、R429、L555及T559的位置處之修飾。在一些實施例中,修飾為選自由以下組成之群的胺基酸取代:Q317R、S319R、I322K、Q323G、R429G、L555K及T559V。在一些實施例中,經修飾重組酶相對於屎腸球菌聚合酶(SEQ ID NO: 2)具有增加之DNA結合親和力。
在一些實施例中,經修飾重組酶包含對應於SEQ ID NO: 2之E391、S503及E523之一或多個位置處之修飾。在一些實施例中,修飾為選自由以下組成之群的胺基酸取代:E391Y、E391W、E391F、E391K、S503A、E523K、E523Y、E523F、E523H及E523W。在一些實施例中,經修飾重組酶相對於屎腸球菌聚合酶(SEQ ID NO: 2)具有增加之類似物結合親和力。
在一些實施例中,經修飾重組酶包含一或多個對應於SEQ ID NO: 2之Q206、E436及L437的位置處之修飾。在一些實施例中,修飾為選自由以下組成之群的胺基酸取代:Q206R、Q206K、Q206H、E436R、L437Y及L437E。在一些實施例中,經修飾重組酶相對於屎腸球菌聚合酶(SEQ ID NO: 2)具有改良之股置換。
在一些實施例中,經修飾重組酶包含一或多個對應於SEQ ID NO: 2之E436、L437、R534、T568及M569的位置處之修飾。在一些實施例中,修飾為選自由以下組成之群的胺基酸取代:E436R、L437Y、L437E、R534K、T568D、T568S、M569T及M569V。在一些實施例中,經修飾重組酶相對於屎腸球菌聚合酶(SEQ ID NO: 2)具有增強之平均讀段長度。
在一些實施例中,經修飾重組酶包含對應於以下之一或多個位置處之修飾:SEQ ID NO: 2之T13、V25、C26、D27、N33、I34、F36、S42、D54、E60、M95、T110、T114、K119、P136、P147、E152、I153、P160、N175、F188、S216、R217、D232、A236、V247、P273、P275、E283、V315、S319、L320、Q323、E338、T345、F352、F353、T364、D414、D425、E436、F465、E485、A486、L490、S503、E523、V526、G547、L555、R558、V564、M569及T571。在一些實施例中,修飾為選自由以下組成之群的胺基酸取代:T13N、V25L、C26W、D27E、N33T、I34V、F36V、S42T、D54Y、E60V、M95T、M95K、T110I、T114S、K119Q、P136T、P147Q、P147T、E152D、I153V、P160A、N175Y、F188C、S216G、S216R、R217G、D232H、A236G、V247D、P273R、P275S、E283K、V315L、S319R、L320M、L320T、Q323R、E338K、T345I、F352I、F353C、T364I、D414V、D425N、E436G、F465Y、E485D、A486E、L490M、S503T、E523V、V526L、G547S、L555R、R558H、V564L、M569K及T571S。在一些實施例中,經修飾重組酶相對於屎腸球菌聚合酶(SEQ ID NO: 2)具有增加之複製能力。
在一些實施例中,經修飾重組酶包含對應於以下之一或多個位置處之修飾:SEQ ID NO: 2之E139、E142、N145、I148、D167、D171、D189、D374、E385、E391、N467、E482、D492、K495、D521、E523、D533、E537及E545。在一些實施例中,修飾為選自由以下組成之群的胺基酸取代:E139K、E139Q、E139R、E139H、E142K、E142H、E142R、E142Q、N145K、N145H、N145R、I148K、I148H、I148R、D167P、D167K、D167H、D167R、D171K、D171H、D171R、D189K、D189H、D189R、D374G、D374Q、D374H、E385Y、E385K、E385R、E385N、E385Q、E385L、E385A、E391Y、E391W、E391K、E391F、N467R、N467K、N467H、N467S、N467T、E482K、E482H、E482R、D492H、D492K、D492R、K495R、D521K、D521H、D521R、E523K、E523Y、E523H、E523R、E523F、E523W、D533A、D533Q、D533T、D533R、D533S、E537K、E537H、E537R、E545K、E545H及E545R。在一些實施例中,經修飾重組酶相對於屎腸球菌聚合酶(SEQ ID NO: 2)具有增加之正電性表面電荷。
在一些實施例中,經修飾重組酶包含對應於以下之一或多個位置處之修飾:SEQ ID NO: 2之K4、S22、D27、I34、D54、E60、E85、M95、N106、T110、Q122、Y133、P136、P147、D167、T211、D232、P275、R308、S319、L320、E323、D337、E338、D341、T345、F352、T364、D414、F465、T479、E485、L490、S493、Q513及R558。在一些實施例中,修飾為選自由以下組成之群的胺基酸取代:K4R、S22A、D27E、I34V、D54Y、E60V、E60L、E85P、M95K、T110I、N106G、Q122V、Y133L、P136T、P147Q、P147T、D167P、T211A、D232K、P275S、R308G、S319R、L320M、Q323V、D337G、E338K、D341T、T345I、F352I、T364I、D414V、F465Y、T479V、E485D、L490M、S493P、Q513D及R558H。在一些實施例中,經修飾重組酶相對於屎腸球菌聚合酶(SEQ ID NO: 2)具有增加之穩定性。
在一些實施例中,經修飾重組酶包含表7中所列之修飾之組合。
經修飾聚合酶相對於野生型聚合酶(例如表1之序列,例如SEQ ID NO: 1、SEQ ID NO: 2-5、SEQ ID NO: 6-22或SEQ ID NO: 23-33)或相對於表2-7中任一者中所描述之序列,可包括一或多個修飾(例如,如此申請案中所述之一或多個胺基酸之缺失、一或多個胺基酸之添加、一或多個胺基酸之取代,或其組合)。
在一些實施例中,經修飾聚合酶中之唯一修飾為本發明中所提供之修飾(例如胺基酸取代)中之一或多者,且聚合酶之序列另外與野生型聚合酶(例如表1之序列)或與表2-7中之任一者所描述之序列一致。
在一些實施例中,經修飾重組酶進一步包含純化標籤。在一些實施例中,純化標籤共價鍵結至聚合酶序列中之區域。在一些實施例中,純化標籤共價鍵結在聚合酶序列之末端。在一些實施例中,純化標籤係C端標籤。在一些實施例中,純化標籤係N端標籤。在一些實施例中,純化標籤係His標籤(例如重複組胺酸殘基之序列,諸如六組胺酸序列)。
在一些實施例中,經修飾重組酶進一步包含偶合基團。在一些實施例中,偶合基團附接在經修飾重組酶序列內之區域處。在一些實施例中,偶合基團附接在經修飾重組酶之末端處。在一些實施例中,偶合基團附接在經修飾重組酶之C末端處。在一些實施例中,偶合基團附接在經修飾重組酶之N末端處。在一些實施例中,偶合基團係生物素標記序列。在一些實施例中,偶合基團係雙生物素標記序列。在一些實施例中,經修飾重組酶包含(例如在其C端處)直接連接或由肽連接子(例如5至15個胺基酸長或更長)分開之純化標籤(例如His標籤)及偶合基團(例如生物素標記或雙生物素標記序列)。
在一些實施例中,經修飾重組酶固定於表面上。在一些實施例中,表面包含經組態以結合經修飾重組酶之偶合基團。在一些實施例中,表面包含奈米孔口。在一些實施例中,表面包含樣品槽之底表面。在一些實施例中,樣品槽安置於表面(例如晶片或積體裝置之表面)上之複數個樣品槽之中。在一些實施例中,複數個樣品槽中之每一者經組態以接收經修飾重組酶。在一些實施例中,包含經修飾重組酶之複數個樣品槽中之每一者能夠進行單分子定序反應。在一些實施例中,表面可為由玻璃或其他透明材料、矽石、熔融矽石、二氧化矽、聚合物、其他材料或其組合製成的晶片之表面(例如,不同層之組合,例如包括一或多個金屬層)。
在一些態樣中,本發明提供編碼本文所述之經修飾重組酶的經分離核酸分子。在一些實施例中,經分離的核酸分子包含RNA。在一些實施例中,經分離的核酸分子包含DNA。在一些實施例中,經分離的核酸分子包含病毒載體。在一些實施例中,經分離的核酸分子包含表現載體。在一些實施例中,經分離的核酸分子包含質體。在一些實施例中,經分離核酸包括啟動子(例如誘導型啟動子)。在一些實施例中,經分離核酸處於能夠表現經修飾重組酶之宿主細胞中。在一些實施例中,經修飾重組酶自宿主細胞(例如自宿主細胞製備物,例如在生物反應器中生長及誘導誘導型啟動子之後)分離。
在一些態樣中,本發明提供一種包含此申請案中所述之經修飾重組酶的組合物。在一些實施例中,組合物用於定序核酸之方法中。在一些實施例中,組合物進一步包含定序反應混合物。在一些實施例中,定序反應混合物可包括:聚磷酸核苷(例如包含多於一個磷酸基之核苷,諸如六磷酸核苷酸或核苷)中之一或多者、待定序之模板核酸、充當互補股合成之起始點之核酸引子、二價金屬離子、緩衝組分及鹽。在一些實施例中,聚磷酸核苷包含可偵測部分(例如發光標記)。
在一些態樣中,本發明提供一種藉由使此申請案中所述之經修飾重組酶與定序反應混合物接觸來定序核酸之方法。在一些實施例中,定序反應混合物可包括:聚磷酸核苷(例如包含多於一個磷酸基之核苷,諸如六磷酸核苷酸或核苷)中之一或多者、待定序之模板核酸、充當互補股合成之起始點之核酸引子、二價金屬離子、緩衝組分及鹽。在一些實施例中,聚磷酸核苷包含發光標記。在一些實施例中,該方法進一步包含偵測在與模板核酸互補之生長股中之一或多個聚磷酸核苷之併入。在一些實施例中,偵測包含量測涉及併入事件中之經發光標記之聚磷酸核苷之一或多個發光特性(例如壽命、強度、光子出現時間、量子產率)。
在一些態樣中,本發明係關於包含本文所述之經修飾重組酶的組合物。
在一些態樣中,本發明係關於使用本文所述之重組酶定序核酸之方法。在一些實施例中,該方法包含使經修飾重組酶與定序反應混合物接觸。
此等及其他態樣在以下詳細描述中更詳細地描述且藉由非限制性圖式及實例說明。
相關申請 本申請案根據35 U.S.S. § 119(e)主張2019年6月28日申請之美國臨時專利申請案第62/868,806號及2020年3月23日申請之美國臨時專利申請案第62/993,597號之優先權,其中之每一者以全文引用之方式併入本文中。
本發明之態樣係關於經修飾聚合酶及其組合物。在一些態樣中,本發明提供使用經修飾重組聚合酶及包含該等酶之組合物之方法。在一些實施例中,本發明提供可用於進行活體外聚合反應之經修飾重組聚合酶及其組合物。在一些態樣中,本文中所描述之聚合酶係經修飾重組核酸聚合酶,例如經修飾重組DNA聚合酶。在一些實施例中,由本發明提供之經修飾重組DNA聚合酶可用於與DNA操控(例如DNA定序)相關之活體外反應。
I. 經修飾聚合酶 在其他態樣中,本發明提供可用於進行活體外聚合反應之經修飾聚合酶(polymerizing enzyme)(或經修飾聚合酶(polymerase))。在一些實施例中,本文中所描述之聚合酶包含適用於進行定序反應之個別或呈組合形式之一或多個修飾。在一些實施例中,可利用一或多個本文中所描述之修飾來產生具有一或多個適用於進行定序反應之特性的聚合酶,例如,諸如以下之特性:聚合酶持續效力、保真性(例如精確度)、受質(例如聚磷酸核苷)結合親和力、受質利用率(例如聚磷酸核苷併入至與模板股互補之生長股中之比率)、聚合酶與經修飾受質(例如經標記聚磷酸核苷)之相互作用或其某種組合。在一些實施例中,一或多個修飾最小化或消除聚合酶之校讀能力。舉例而言,在一些實施例中,可對聚合酶之外切核酸酶域作出一或多個修飾,使得聚合酶之外切核酸酶活性受損。
本申請案部分地基於本發明人之認識:對野生型聚合酶之某些修飾(例如突變、插入及/或取代)增強該等聚合酶之功能屬性,以提供用於核酸操縱應用之改良試劑。因此,在一些態樣中,本發明係關於經修飾聚合酶。如本文所用,術語「聚合酶(polymerase)」及「聚合酶(polymerizing enzyme)」一般係指能夠催化聚合反應之任何酶。聚合酶之實例包括但不限於DNA聚合酶、RNA聚合酶、熱穩定聚合酶、野生型聚合酶、重組聚合酶、大腸桿菌DNA聚合酶I、T7 DNA聚合酶、噬菌體T4 DNA聚合酶φ29 (phi29) DNA聚合酶、Taq聚合酶、Tth聚合酶、Tli聚合酶、Pfu聚合酶、Pwo聚合酶、VENT®聚合酶、Deep VENT™聚合酶、Ex TAQ™聚合酶、LA TAQ™聚合酶、Sso聚合酶、Poc聚合酶、Pab聚合酶、Mth聚合酶、ES4聚合酶、Tru聚合酶、Tac聚合酶、Tne聚合酶、Tma聚合酶、Tca聚合酶、Tih聚合酶、Tfi聚合酶、PLATINUM® Taq聚合酶、Tbr聚合酶、Tfl聚合酶、Tth聚合酶、PFUTURBO®聚合酶、PYROBEST™聚合酶、Pwo聚合酶、KOD聚合酶、Bst聚合酶、Sac聚合酶、克列諾(Klenow)片段,具有3'至5'外切核酸酶活性之聚合酶及其變異體、修飾產物及衍生物。在一些實施例中,聚合酶為單一子單元聚合酶。聚合酶之其他實例包括M2Y聚合酶、銅綠蠅(Lucilia cuprina )聚合酶、屎腸球菌(Enterococcus faecium )聚合酶、芽孢桿菌(Bacillus )噬菌體VMY22聚合酶、芽孢桿菌噬菌體GA-1聚合酶、放線菌(Actinomyces )噬菌體AV-1聚合酶、候選莫蘭菌(Candidatus Moranbacteria )聚合酶、芽孢桿菌噬菌體MG-B1聚合酶、埃格特菌屬(Eggerthella sp. )聚合酶、鏈球菌(Streptococcus )噬菌體CP-7聚合酶、擬桿菌屬(Bacteroides sp. )聚合酶、沙眼披衣菌(Chlamydia trachomatis )聚合酶及馬鈴薯球胞囊線蟲(Globodera pallida )聚合酶。DNA聚合酶之其他非限制性實例包括9°NM™ DNA聚合酶(新英格蘭生物實驗室(New England Biolabs))及克列諾外聚合酶之P680G突變體(Tuske等人(2000) JBC 275(31):23759-23768)。DNA聚合酶之非限制性實例及其特性詳細描述於DNA Replication第2版, Kornberg及Baker, W. H. Freeman, New York, N.Y. (1991)及其他位置中。此類序列之非限制性實例可見於表1中。
如本文中所述,當聚合酶及/或聚合酶序列天然或人工地衍生自共同上代蛋白質或胺基酸序列時其為「同源」。類似地,當核酸及/或核酸序列天然或人工地衍生自共同上代核酸或核酸序列時其為同源。舉例而言,任何天然存在核酸可以藉由任何可利用的誘變方法修飾以在多肽中在給定位置處包括至少一種編碼不會天然存在之胺基酸的特定密碼子。當表現時,此經誘變核酸編碼包含一或多個突變胺基酸之多肽。在一些實施例中,同源性一般根據兩個或更多個核酸或蛋白質(或其序列)之間的序列相似性推斷。適用於確立同源性之序列之間的相似性之精確百分比隨所研究之核酸及蛋白質而變化,但常規地使用小至25%序列相似性來確立同源性。亦可使用更高水準之序列相似性,例如30%、40%、50%、60%、70%、80%、90%、95%或99%或更大,來確立同源性。測定序列相似性百分比之方法已為一般熟習此項技術者所熟知。在一些實施例中,相似性可以使用諸如本文中所述之算法的算法,包括例如BLASTP及BLASTN算法,例如使用預設參數來測定。 表1.例示性野生型聚合酶胺基酸序列
名稱 SEQ ID NO. 序列
Φ29 1 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFKLTVLKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRYAYRGGFTWLNDRFKEKEIGEGMVFDVNSLYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSEGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWARYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRQKTYIQDIYMKEVDGKLVEGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDDTFTIK
屎腸球菌(野生型) 2 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWKHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
屎腸球菌(變異體1) 3 mmikkytgdfetttdlndcrvwswgvcdidnvdnitfgldidsffewcemqgstdiyfhnekfdgefmlswlfkngfkwsketkeertfstlisnmgqwyaleicwevnyattksgktkkekvrtiiydslkkypfpvkqiaeafnfpikkgeidytkerpvgynptddewdylkndiqimamalkiqfdqgltrmtrgsdalgdykdwlkathgkstfkqwfpilslgfdkdlrkaykggftwvnkvfqgkeigdgivfdvnslypsqmyvrplpygtplfyegeykpnndyplyiqnikvrfrlkegyiptiqvkqsslfiqneyldssvnklgvdelidltltnvdlelffehydileihytygymfkascdmfkgwidkwievknttegarkanakgmlnslygkfgtnpditgkvpymgedgivrltlgeeelrdpvyvplasfvtawgryttittaqrcfdriiycdtdsihlvgtdvpeaiehlvdpkklgywghestfqrakfirqktyveeidgelnvkcagmpdrikelvtfdnfevgfssygkllpkrtqggvvlvdtmftik
屎腸球菌(變異體2) 4 mmikkytgdfetttdlndcrvwswgvcdidnvdnitfgldidsffewcemqgstdiyfhnekfdgefmlswlfkngfkwsketkeertfstlisnmgqwyaleicwevnyattksgktkkekvrtiiydslkkypfpvkqiaeafnfpikkgeidytkerpvgynptddeweylkndiqimamalkiqfdqgltrmtrgsdalgdykdwlkathgkstfkqwfpilslgfdkdlrkaykggftwvnkvfqgkeigdgivfdvnslypsqmhvrplpygtplfyegeykpnndyplyiqnikvrfrlkegyiptiqvkqsslfiqneyldssvnklgvdelidltltnvdlelffehydileihytygymfkascdmfkgwidkwievknttegarkanakgmlnslygkfgtnpditgkvpymgedgivrltlgeeelrdpvyvplasfvtawgryttittaqrcfdriiycdtdsihlvgtdvpeaiehlvdpkklgywghestfqrakfirqktyveeidgelnvkcagmpdrikelvtfdnfevgfssygkllpkrtqggvvlvdtmftik
屎腸球菌(變異體3) 5 mikkytgdfetttdlndcrvwswgvcdidnvdnitfgldidsffewcemqgstdiyfhnekfdgefmlswlfkngfkwsketkeertfstlisnmgqwyaleicwevnytttksgktkkekvrtiiydslkkypfpvkqiaeafnfpikkgeidytkerpvgynptddewdylkndiqimamalkiqfdqgltrmtrgsdalgdykdwlkathgkstfkqwfpilslgfdkdlrkaykggftwvnkvfqgkeigdgivfdvnslypsqmyvrplpygtplfyegeykpnndyplyiqnikvrfrlkegyiptiqvkqsslfiqneyldssvnklgvdelidltltnvdlelffehydileihytygymfkascdmfkgwidkwievknttegarkanakgmlnslygkfgtnpditgkvpymgedgivrltlgeeelrdpvyvplasfvtawgryttittaqrcfdriiycdtdsihlvgtdvpeaiehlvdpkklgywghestfqrakfirqktyveeidgelnvkcagmpdrikelvtfdnfevgfssygkllpkrtqggvvlvdtmftik
M2Y 6 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDILSTKKFNKVFPKLSLPMDKEIRKAYRGGFTWLNDKYKEKEIGEGMVFDVNSLYPSQMYSRPLPYGAPIVFQGKYEKDEQYPLYIQRIRFEFELKEGYIPTIQIKKNPFFKGNEYLKNSGVEPVELYLTNVDLELIQEHYELYNVEYIDGFKFREKTGLFKDFIDKWTYVKTHEEGAKKQLAKLMLNSLYGKFASNPDVTGKVPYLKDDGSLGFRVGDEEYKDPVYTPMGVFITAWARFTTITAAQACYDRIIYCDTDSIHLTGTEVPEIIKDIVDPKKLGYWAHESTFKRAKYLRQKTYIQDIYVKEVDGKLKECSPDEATTTKFSVKCAGMTDTIKKKVTFDNFAVGFSSMGKPKPVQVNGGVVLVDSVFTIK
銅綠蠅WT 7 MARKRPIRITKNDRAEYKRLSKNAKSKLNRTVKNYGIDLSNDVDIPKLSDFKTRKEFNDWKQKITSFTSRSNQEYQFRKNEYGVVASVKELNEIKRNTKKAQKIAKEKIDKAMKLDFYVEGERQGKVKDRIKLMKKEEVAGVSVPVDFDFDKIQTRKRLEDKAGFMEERATGDYYRKKDIQMKENFISMIEQGFNSDADEVIKKLKKIPPDDFVELTIVTDEIDFRNYGSKNEGGINDEDKLEELNNTLNDYFNETTTDVNDCRVWAYGWMEIGKTSNYKIGTDFNEFMEWMIHSSSRLYFHNLKFDGSFIVNWLLHNGYTWTKRPSKEGQFSTLISKMGQWYGITICSGRDGRKKKLTTIHDSLKKLPFPVRKIGKDFKLNVLKGDIDYHKPRPIGYEIDDEEYQYIKNDIQIIAEALEVQTVQGLTGMTNGKDALDEFVNMSGKLYEKLFPVFSLELNEEIRKAYRGGFTWLNPVYGTKKYVKDGIVFDVNSLYPSQMYDRDLPCGVPIPFEGEYVYDKSHPLYIQKLTFEFELKENYIPTIQLKNSRFGFKGNEYLSSSNGERITISVSSVDWELIREHYHVYDVEFEKGWKFRSTKQAFRQYIDKWMLVKNMSAGAKKAIAKLMLNSLYGKFATNPDITGKRPYLREDGSNGFELMEEEFRDPVYTPVGIFITSWARYTTITSAQKCYDRIIYCDTDSMHLEGLDVPESIKDIVADDVLGYWKKEGQFKQGKFIRQKTYMEEYYAKYVRDENGEIKYDDEKPIKTICDKEESDTTIIEIKCAGMPDNIKKHVTFDNFDIGFTMEGKLKPKQVYGGVVLVEETYTMK
銅綠蠅修飾 8 MKHMPRKMYSCDFETTTDVNDCRVWAYGWMEIGKTSNYKIGTDFNEFMEWMIHSSSRLYFHDLKFDGSFIVNWLLHNGYTWTKRPSKEGQFSTLISKMGQWYGITICSGRDGRKKKLTTIHDSLKKLPFPVRKIGKDFKLNVLKGDIDYHKPRPIGYEIDDEEYQYIKNDIQIIAEALEVQTVQGLTGMTNGKDALDEFVNMSGKLYEKLFPVFSLELNEEIRKAYRGGFTWLNPVYGTKKYVKDGIVFDVNSLYPSQMYDRDLPCGVPIPFEGEYVYDKSHPLYIQKLTFEFELKENYIPTIQLKNSRFGFKGNEYLSSSNGERITISVSSVDWELIREHYHVYDVEFEKGWKFRSTKQAFRQYIDKWMLVKNMSAGAKKAIAKLMLNSLYGKFATNPDITGKRPYLREDGSNGFELMEEEFRDPVYTPVGIFITSWARYTTITSAQKCYDRIIYCDTDSMHLEGLDVPESIKDIVADDVLGYWKKEGQFKQGKFIRQKTYMEEYYAKYVRDENGEIKYDDEKPIKTICDKEESDTTIIEIKCAGMPDNIKKHVTFDNFDIGFTMEGKLKPKQVYGGVVLVEETYTMK
芽孢桿菌噬菌體VMY22 9 MATKKRKAYSCDFEATTSTYSETETRVWAYGWMEIGNTSHFNIGDNLDEFMLWTSKECADLYFHDLRYDGEFIVNWLLHKGYECNESGRPKTFDTVISKGGQWYKIAIHHEGKGTTQIFDSLKKLPFPVKTIAKAFKLPVLKGDIDYNLHRDENHVITSEEFTYIKHDIEIVARALDIQINQQGLVKMTNGADSMDHFIKSLDKKKKVAERIYNQYFPKMSIAMDSIFRKAYRGGFTWVNPKFKGQEVGEGMVFDVNSLYPSVMYYKPLPWGKPVPFVGKYEEDPDFPLYICHIKTGFVLKEGHIPTIQIKKNPIFQENEYLETSGGAPVDLHVTNVDLELIKEHYELYDTEYVGGWKFRQQTGIFNNFIDYWMKIKTDPKSTPAIVTLAKLQLNSLYGKFASHPDVTGKVPYLKDDGSTAFKKGLPKSKDPVYTPAGAFITAWARHMTITTAQKVYDRILYCDTDSIHILGIDIPEAIKNDIHQKELGKWAFECMFKRAKFVRQKTYVEDMYAKFMSYWEDGELNYMLKECVKEEATARLLNVKCAGMPQAVKKFVTFRTFAVGFTSDTGKLKPKHVKGGQILVDVPFTIK
芽孢桿菌噬菌體GA-1 10 MARSVYVCDFETTTDPEDCRLWAWGWMDIYNTDKWSYGEDIDSFMEWALNSNSDIYFHNLKFDGSFILPWWLRNGYVHTEEDRTNTPKEFTTTISGMGQWYAVDVCINTRGKNKNHVVFYDSLKKLPFKVEQIAKGFGLPVLKGDIDYKKYRPVGYVMDDNEIEYLKHDLLIVALALRSMFDNDFTSMTVGSDALNTYKEMLGVKQWEKYFPVLSLKVNSEIRKAYKGGFTWVNPKYQGETVYGGMVFDVNSMYPAMMKNKLLPYGEPVMFKGEYKKNVEYPLYIQQVRCFFELKKDKIPCIQIKGNARFGQNEYLSTSGDEYVDLYVTNVDWELIKKHYDIFEEEFIGGFMFKGFIGFFDEYIDRFMEIKNSPDSSAEQSLQAKLMLNSLYGKFATNPDITGKVPYLDENGVLKFRKGELKERDPVYTPMGCFITAYARENILSNAQKLYPRFIYADTDSIHVEGLGEVDAIKDVIDPKKLGYWDHEATFQRARYVRQKTYFIETTWKENDKGKLVVCEPQDATKVKPKIACAGMSDAIKERIRFNEFKIGYSTHGSLKPKNVLGGVVLMDYPFAIK
放線菌噬菌體AV-1 11 MVRQSTIASPARGGVRRSHKKVPSFCADFETTTDEDDCRVWSWGIIQVGKLQNYVDGISLDGFMSHISERASHIYFHNLAFDGTFILDWLLKHGYRWTKENPGVKEFTSLISRMGKYYSITVVFETGFRVEFRDSFKKLPMSVSAIAKAFNLHDQKLEIDYEKPRPIGYIPTEQEKRYQRNDVAIVAQALEVQFAEKMTKLTAGSDSLATYKKMTGKLFIRRFPILSPEIDTEIRKAYRGGFTYADPRYAKKLNGKGSVYDVNSLYPSVMRTALLPYGEPIYSEGAPRTNRPLYIASITFTAKLKPNHIPCIQIKKNLSFNPTQYLEEVKEPTTVVATNIDIELWKKHYDFKIYSWNGTFEFRGSHGFFDTYVDHFMEIKKNSTGGLRQIAKLHLNSLYGKFATNPDITGKHPTLKDNRVSLVMNEPETRDPVYTPMGVFITAYARKKTISAAQDNYETFAYADTDSLHLIGPTTPPDSLWVDPVELGAWKHESSFTKSVYIRAKQYAEEIGGKLDVHIAGMPRNVAATLTLEDMLHGGTWNGKLIPVRVPGGTVLKDTTFTLKID
候選莫蘭菌 12 MKLKSKYVADFEATGEEQYKIDGSTHVWAVGVIDIETEETVLISNDIADFMNWLSKDNHNHKNKEVFFHNLKYDGDFIVKFLLENGFKHSRERALYSNEFSTLISDTGTWYEIKICFHALKTRKVEVKIHDSYKLLPFSEEKIAKAFKLTVSKGEIDYDRYRPVGYQLQEYEVDYLKTDLLIMAQALKVQMNKGLTKMTIGSNALADYKQRISKDKFKYLFPVLDNIIDADLRHAYRGGHTYLQPFYANKILENVHSYDKNSMHPSQMKNMPMPYGIPVYYEGEYKNDPDYPLFIQSIEIDCKVKKGYLPTIQPRNAFRFATTEFLEDTKGEPIQLFVTSIDLMLILEHYDIHYIQYLEGFKFRSHIGLFDEYIDYWYHIKETNTGPLREIAKLMLNNLYGKFGTNPIRARKEPIYDKTKGAVYVNLPAEEGDAVYIPMACFITAYSRYDLISTAQKFYKNVVYMDTDSIKFYGISREVIEAQIEVHDTKIGAWKYEGTAKMFKALRPKTYAYIDENDELDVKCAGLPKKAKKDITFDTFQYGFVSKEKLEIKRVKGGTILLKTKFEIKKQVDNKHIDTEYFEDEDIDIFNQL
芽孢桿菌噬菌體MG-B1 13 MKKKRTKTKIKTYACDFETNTEAWLHEDKLRDELKTKEENPELWRKREAWKLHTGGDKAFVWSWGGTEIREDMSFKGELDNFVVGKGISEYVDWMLDGSKNVWFHNLKFDGSFIAVELLRRGFKFTFDRNPAIGEFTGLIDGKKMWFELIICKEGKRGGRQFITIKDSLKKVPFGLRVAAMAFGLDVFKDDMDYDVIREPFEPIGEADYKYLKKDVEITAKIIHYQVFQSGLKKTTIGSDALNEFKSTVGGDKGFKEIFPVMDFDTDSFIRKSYFGGVTQVKPGMEGKLIGEGSVFDIVSMYPWVQYTKLLPYGLPIEYNGEYTYDEEYPLYVQQVSFSFVVKDNMLPTIQLKKQNVEFNYNEADDVRKFNGREFQKTSYGEIVTMYVTNVQWEQIQKHYWLDDLHFHKGMMFKGKIGLFKEHIDKWLKVKKQANDDGNDALKSLAKLMLNSPYGKFGTNTIRLNVEPFLWEDDESLGFRVEDDDPPPADPIYTAYASFVTAYAREELVSTIMMCYDRFVYCDTDSIHLIGTEIPEGIKHKIGGDLGDWEPESEFKLAKFHRAKTYCEMVYAKKVMKKDRWGDVVESLKHCSKEEWGTLPQDQKTLDKNLKCAGLQGHLKDYVSFEEFEIGLKINPEVNKDIMGKPLGKLMPCQVKGGTLLKVRKFSLN
埃格特菌屬 14 MNEYISDFETQKDPDTGVMSVWAWSIVDVNDLSNIQYGNNIESWLSAIQGLPNGSLIGFHNLKFDGSYILSYLLGVAKWEYNDKPKARKAKTVECLISSIGVHYNYRINFTKRKYVKIYDTLKIFNMSVSQIAKSFGIKEQKGSIDYAIFRGYNYTMTPKEVEYITNDVKIVAKAIKQFRNEGHERNTIASNAMRYYKKNSYYSNYEFLTYFPHLDDDLYHLLKRAYKGGYCYVNPKFKGKPVGHGRVYDVNSLYPSVMSDPQNKYPIGTPVFFEGKYKDDPIYPLYIQFITAQFELKKGKIPTIQIKNDKRFNPREYVTSTGCLMVNLYLTNVDLEMFYECYNIKEIQYIGGYKFIGRSGIFIDYVNHFKEMKMQATIEKNAGKRSIAKLFLNSLYGKFGASNDKFVKRPYINDKGILAYQTVETPRPAKTVYVPVAAFVTAYARRFIQTLFIKNVDRCCYCDTDSLHLIGDDPPEGVKISDTEFNCMAHESSFSRAKFLGAKLYIEEDEQGNLDVKAAGLGQNEVVKNQITFDNFNTEQEYFGILKSKTVQGGVELSESTFKIRERGTRF
鏈球菌噬菌體CP-7 15 MTCYYAGDFETTTNEEETEVWLSCFAKVIDYDKLDTFKVNTSLEDFLKSLYLDLDKTYTETGEDEFIIFFHNLKFDGSFLLSFFLNNDIECTYFINDMGVWYSITLEFPDFTLTFRDSLKILNFSIATMAGLFKMPIAKGTTPLLKHKPDEIKPEWIDYIHVDVAILARGIFAMYYEENFSKYTSASEALTEFKRIFRKSKRKFRDFFPILDEKVDDFCRKAYRGGWTFANPKTQGRTLKQLIDIYDINSMYPATMLQNALPIGIPKRYKGKPKEIKEDHYYIYHIKADFDLKRGYLPTIQIKKKLDALRIGVRTSDYVTTSKNEVIDLYLTNFDLDLFLKHYDATIMYVETLEFQTESGLFDDYITTYRYKKENAQSPAEKQKAKIMLNSLYGKFGAKIISVKKLAYLDDKGILRFKNDDEEEVQPVYAPVALFVTSIARHFIISNAQENYDNFLYADTDSLHLFHSDSLVLDIDPSEFGKWAHEGRAVKAKYLRSKLYIEELIQEDGTTHLDVKGAGMTPEIKEKITFENFVIGATFEGKRASKQIKGGTLIYETTFKIRETDYLV
擬桿菌屬 16 MSKKSAKKPVIIAADFETTVYPGQTSTEVWSAAWIELFTERPHVRGNIEDFLNDIFNLNKNVLCYFHNLRFDGAFIVYWLLKNGYTWNNARNKGMNAKEFKALISDTNKWYTVTVKPKFDTVIEFRDSVKLMPMTLDQIGSAFNTKHRKLEMEYIGMRHANCEITPEEYAYIINDIYVLKEALEVMIKSGHDKLTIGSCCMDEFKNKFDAMDFKAAFPNLKEIALIKYELGSDNVDQYIRKAYKGGYCYYKYKQRKHITQNGMTFDVNSLYPSVMHSKSGNYYPTGKPIFFEKAIPYKCLEARVYPFYVRLRCRFKLKDGFLPTVQIKGDYKYNSTQWLETSDIYYRGKYYRYFTNKEGQKEEARPELTLFMTDYLLLLEHYDVYDLEILDGCYFHGAIGLFDTYIDHYMKIKMTTKDKGERTEAKLFLNNLYGRLAINDNSSYREPFIDPETDSIGFELHPEHEKDTLYIAAGAAVTAYARYFTITHAQANYQNFVYSDTDSIHMLDDGQPVKMIKEHATELLHWKRESDWSSAIFIRQKTYAEFVQKEDGKKVTGHWEIKCAGMPEKSKKLFLASHPITDFKIGLKVGGKLKPKYISGGMVLVEDFYTLRAKRC
沙眼披衣菌 17 MKARKFKIYAADFETTVFKGQTFTEVWSACFCELYKKDAKIMHSIQDFFNYFFSLNENIKMYFHNLKFDGSFILSYLLKDLKYEQAYEKMNADGSLVRWLETKDMKNNSIKYSISEMGQWYYIIIKKNNKIIEIRDSLKLLPFSLEAIGKSFDTEHKKLKMKYEGYRYAGCEITPEEQAYIKNDVLVLKEALEIMFNEKHESLTIGSCCLNEYKTIMTKFLIERLYPNIAEYTVNVPLEFKNADEYVRKSYKGGWCYLKKGCENKIYNNGTTADVNSLYSSVMHSESGNYYPVGLPTFWSGNYIPEIAKEKYYFIRIKTRFYLKKRFLPCIQVKNTYRYKSTEWLETSDFYDKKTNKYYKKYLDINGNEQNTQVILTLTMTDFELIKEHYNLVDFEILDGCYFDKEIGLFDEYINKYKKIKLNSKGAKKTLAKLYLNNLYGKTATNTDSSFKVAYIKDDLSLGFYGVYACDKKPFYIPVGSAITSYARNFTIRAAQKNYKNFIYADTDSIHCKCNPAEIKGITIDDKKFLCWKLESCWDKGLFVRQKTYIEHITAENLKPIDKPFYNVKCAGMPEQCKTLFLKSIGEDVDISDLNINDDAKEFLKKKRTIKDFKAGLSVPLKLRPVQINGGVLLTETFYTM
馬鈴薯球胞囊線蟲 18 MPLPRKKASSNGLSKRIYLADFETTTQAEDCRVWSWGLCSVENTENVEFGGDLDSFIERISEENSITFFHNLKFDGAFILDRLFRLGYEFTDEKAPQVKEFSTLISKMGQFYSIKVRWENGMFTEFRDSLKKLPMSVKQVAKTFKLDQAKGEIDYHYLRPVGWVMTPEEREYVKNDVQIVARALKVQLQEGMTRLTVGADSLAQYKSMMGKDFERHFPVLTRTIDAEIRRAYRGGWAYADERHRGKVVGAGQTFDVNSLYPSVMYSKVLPYGEPVFYPNGLPEVTEDHPLFITCITFTAKIRDGHLPCIQIKNSSLFTPTEYVKEVLDPITMYCTNVDLELWQEHYDMDILAYNGAWLFRGIRGFFNDYIDHWMRIKEESEGGRKLIAKLHLNSLYGKFATNPDVTPKIPIFDEEKDIVRLIEGPPDERNPVYTAMGVFITSYARDLTIRTAQDHYDRFLYADTDSLHLLTSDGTNNGRKSKALEVHPSKLGYWKHEYDFDAGLFVRAKAYTELMTGEFHVKSKCECDTPNDLHYQTHIAGMPEAIAQHITFESYRDGATFEGKLAPQRVPGGI
馬鈴薯包囊線蟲(Potato cyst nematode) 19 MPLPRKKASSNGLSKRIYLADFETTTQAEDCRVWSWGLCSVENTENVEFGGDLDSFIERISEENSITFFHNLKFDGAFILDRLFRLGYEFTDEKAPQVKEFSTLISKMGQFYSIKVRWENGMFTEFRDSLKKLPMSVKQVAKTFKLDQAKGEIDYHYLRPVGWVMTPEEREYVKNDVQIVARALKVQLQEGMTRLTVGADSLAQYKSMMGKDFERHFPVLTRTIDAEIRRAYRGGWAYADERHRGKVVGAGQTFDVNSLYPSVMYSKVLPYGEPVFYPNGLPEVTEDHPLFITCITFTAKIRDGHLPCIQIKNSSLFTPTEYVKEVLDPITMYCTNVDLELWQEHYDMDILAYNGAWLFRGIRGFFNDYIDHWMRIKEESEGGRKLIAKLHLNSLYGKFATNPDVTPKIPIFDEEKDIVRLIEGPPDERNPVYTAMGVFITSYARDLTIRTAQDHYDRFLYADTDSLHLLTSDGTNNGRKSKALEVHPSKLGYWKHEYDFDAGLFVRAKAYTELMTGEFHVKSKCECDTPNDLHYQTHIAGMPEAIAQHITFESYRDGATFEGKLAPQRVPGGIVLVDDTFTIK
伊比利亞猞猁腸(Iberian lynx gut) 20 MPSYTADFETTTVADDCRVWAWATSRIGNPDDVQLGNSIDTFLEWCRVHSGSRVYFHNLKFDGKFILHKILTDGWKWIPDKNDCANRTFTTLISDMSQFYSIKLWFDESKSIEFLDSLKVIPLPIAAIPKAFGLEIEKLDLDYQASREVGHELTEDEKEYIAHDVKIAAMAMDTMFSQGMKKITAGSNAFADYKKTIGGKKRFRDWFPEPEYDEDLRKGGCYKGGFTAVNPKIAGKKLGKGVSFDVNSLYPSVMASSHGEVLPYGEPIPYDGGYEQDEDHPLYIQFIEADFAVKENRIPCLQLKGNVMFGETEYIRDSKGMQTLCLTSVDMEMLFEHYXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRTIAKLQLNSLFAANPVKQSRMPYLDEGIVKYALLEPEHAEAQYLPAGAFITSYARQFTIRAAQANYERWLYCDTDSVYLRGTEPPVDMRVDAYELGAWKKEHEFDCFKAIRAKTYCFEEDGELTVHCAGMPARCHEHVTMDNFEVGASFPGKLKPKDVNGGTILVEDVFTIRP*
屎腸球菌(SK) 21 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLDIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWSKETKEERTFSTLISNMGQWYALEICWEVNYTTTKSGKTKKEKVRTIIYDSLKKYPFPVKQIAEAFNFPIKKGEIDYTKERPVGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYKDWLKATHGKSTFKQWFPILSLGFDKDLRKAYKGGFTWVNKVFQGKEIGDGIVFDVNSLYPSQMYVRPLPYGTPLFYEGEYKPNNDYPLYIQNIKVRFRLKEGYIPTIQVKQSSLFIQNEYLDSSVNKLGVDELIDLTLTNVDLELFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDRIIYCDTDSIHLVGTDVPEAIEHLVDPKKLGYWGHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
芽孢桿菌噬菌體哈蘭貝(Bacillus phage Harambe) 22 MGNKKRKIYSCDFETTTDVNDCRVWAYGLMEIDGKFENYKEGNNIDEFMEWTEQEQGDLYFHNLRFDGEFIVNWLLHKGYRFNNTRKAGTFNAVISSMGQWYKIDIYYGREGKKVFKTSIYDSLKKLPFPVKTIAKAFKLPIEKGDIDYDAPRPVGHQITPDESKYIKNDVEIIARALHSQLNTAKLTKMTIGSDALDGFKHSLHKSPKVSKRMYDHHFPVISNAIHEEFKKAYRGGFTWANPKYAGKVIGNGLVFDVNSLYPSVMYDKPLPYGLPVPFSGEYEYDETHPLFIQHIKCGFELKDGHIPTIQIKKNFRFADNEYLHSSEGNILDLHVTNVDLALIKEHYTLYEEEYLQGYKFKQVTGLFKNYIDYWSDKKINAEDPAIRQMAKLMLNSLYGKFGTSIDVTGKEVFLKEDGSTGFRKGQKEERDPVYMPMGAFITAYARDVTIRTAQKCYDRILYCDTDSIHLVGTEIPEAIKDRIHDKKLGYWAHESTFWRAKFIRQKTYIEDLCMRFEGEKVNGEWKFKMVEEKDITKATARELSVKCAGMPAQVKQYVTFDNFGVDFKHDPNDYTDEEIKRKNIKFKLKPTHRKGGQVLVPTPFTIK
芽孢桿菌病毒B103 23 mprkmfscdfetttklddcrvwaygymeignldnykignsldefmqwvmeiqadlyfhnlkfdgafivnwlehhgfkwsneglpntyntiiskmgqwymidicfgykgkrklhtviydslkklpfpvkkiakdfqlpllkgdidyhaerpvgheitpeeyeyikndieiiaraldiqfkqgldrmtagsdslkgfkdilstkkfnkvfpklslpmdkeirrayrggftwlndkykekeigegmvfdvnslypsqmysrplpygapivfqgkyekdeqyplyiqrirfefelkegyiptiqikknpffkgneylknsgaepvelyltnvdleliqehyemynveyidgfkfrektglfkefidkwtyvkthekgakkqlaklmfdslygkfasnpdvtgkvpylkedgslgfrvgdeeykdpvytpmgvfitawarfttitaaqacydriiycdtdsihltgtevpeiikdivdpkklgywahestfkrakylrqktyiqdiyakevdgkliecspdeatttkfsvkcagmtdtikkkvtfdnfrvgfsstgkpkpvqvnggvvlvdsvftik
芽孢桿菌病毒phi29 24 mprkmyscdfetttkvedcrvwaygymniedhseykignsldefmawvlkvqadlyfhnlkfdgafiinwlerngfkwsadglpntyntiisrmgqwymidiclgykgkrkihtviydslkklpfpvkkiakdfkltvlkgdidyhkerpvgykitpeeyayikndiqiiaealliqfkqgldrmtagsdslkgfkdiittkkfkkvfptlslgldkevryayrggftwlndrfkekeigegmvfdvnslypaqmysrllpygepivfegkyvwdedyplhiqhircefelkegyiptiqikrsrfykgneylkssggeiadlwlsnvdlelmkehydlynveyisglkfkattglfkdfidkwtyikttsegaikqlaklmlnslygkfasnpdvtgkvpylkengalgfrlgeeetkdpvytpmgvfitawaryttitaaqacydriiycdtdsihltgteipdvikdivdpkklgywahestfkrakylrqktyiqdiymkevdgklvegspddytdikfsvkcagmtdkikkevtfenfkvgfsrkmkpkpvqvpggvvlvddtftik
芽孢桿菌噬菌體(Beechbum) 25 mgnkkrkiyscdfetttdvndcrvwayglmeidgkfenykegnnidefmewaekeqgdlyfhnlrfdgefivnwllhkgyrfnntrkagtfnavissmgqwykidiyygregkkvfktsiydslkklpfpvktiakafklpiekgdidydaprpvghqitpdeskyikndveiiaralhsqlntakltkmtigsdaldgfkhslhkspkvskrmydhhfpvisnaiheefkkayrggftwanpkyagkvignglvfdvnslypsvmydkplpyglpvpfsgeyeydethplfiqhircgfelkeghiptiqikknfrfadneylhssegnildlhvtnvdlalikehytlyeeeylqgykfkqvtglfknyidywsdkkinaedpairqmaklmlnslygkfgtsidvtgkevflkedgstgfrkgqkeerdpvympmgafitayardvtirtaqkcydrilycdtdsihlvgteipeaikdrihdkklgywahestfwrakfirqktyiedlcmrfegervngewkfkmveekditkatarelsvkcagmpaqvkqyvtfdnfgvdfkhdpndfteeeikrknikfklkpthrkggqvlvptpftik
芽孢桿菌噬菌體(Karezi) 26 msrnrpvyvadfeattdpndcrvwawgvmdiynqenwtydhdiqsfinwlsssncemyfhnlkydgsfivnwllhngfthvedepkqkfqfstvisgmgqwyvieinfgwvnrkksivkiydslkklpfkvsqiakgfkldqlkgdidyhkprpigyvmdkeeldylyndlkivadalviqfeqgldkmtngsdalagfkdiigkkgyeklfpvydlelneqvrmayrggftwvnpkfqgqpidggrvydvnsmypammmykelpvgmpqiffgeyeydpeyplyiqhlrcyfdvkedhipciqikghvffkkneyitstqdhyvdlyvtnvdlelikdhynltdveyvkgykfrsqtgifkdyiekwmevksspdstaaqvilaklmlnslygkfatnpnvtgkvpylkengalafrkgeesfrdpiytpmgcfitayarenvirtaqklqhrfiyadtdsihvagleeaeaiadqihpsklgywdhettfekamylrqktyflvtcskenekgklipalpseatnrknkiacagmndtikgkvtfeefrigfksngslkpkqvfggvvlmdqpfeik
HBM70020.1 27 MRFTADFETTTDPNDCRVWAWGLCLIDDIDIFYYGTTIDSFMDFLKEHNEITHLYFHNLKFDSEFIIYWLYHHNFKYVKDKRDVVCKSFSTLISDKGQFFSMEIGITMQRTVKIFDSLKVLPFSIAKIADAFHLPFSKLEIDYNAYRAPDHKLKDEEIKYIRGDVTIAALALKQLFSQNMKKMTTASNAMAEYREIVGESTFNKWYPVPVYDADIRQSYRGGFTYLAERYADKDIKEGIVLDVNSLYPSVMYYSPLPFGEGIYFEGKYEQDKEYNLYTQTFSCMFELKEGYIPTVQIKGSLAFVPTEYLKSSGDEYVTMTMTNVDLEMFLEHYEVYDIDYHCGWKFKSTTGLFKDYIDKWNGVKVQATIEKNGGLRTIAKLMLNSLYGKFALNPKVASKIPYLGEDDVIHYYVTDIEEREPIYIPVGTFITAWARHKTITSAQSVYDRFIYADTDSLHLEGLEEPKGLEISDTKLGAWKKESVFTRARFLRQKSYMEEIDGKLKITCAGMPPACYPYVTWDNFHIGATYPFRLRPMHTQGGIVLVNAPFTIRK
拜氏梭菌(Clostridium beijerinckii ) 28 miatadfetttlendcrvwayaiceignydnficgnsiddffefcmdkyenhilyfhnlkfdgefifywlfrngyehvedrkqlesktfttlisdkgqfysieicftkkgkktnkltiydslkilnfsvqkigkdfnlpvlkidkeqefytkfrevghilteeekqyiqndvevvaralkelfdremnkmtigadalnnykvmtgkatfekmfpildnetdknirasyrggftflnekyknkavangivldvnslypwvmyecplpfgepiyfegkykqdkiynlyiqhfkcqfelkkgyiptlqlkhnlafipteyvkdsgteeviltltsvdlelflehynvynvewisgykfksstemfksyvdfwinekinakkehngamytlaklmlnslygkfalspvvrgkfplydekedfihykysqeesrkpiyipvgtfitswarnktirsaqknydrfiyadtdslhlegleipeelqiddyilgawkheltfskakylraksymeygkepntddeekwkitvagmptncyqyvdfenfkvgavykgklqhhrvsggvilketeftikm
琥珀酸弧菌屬(Succinivibrio sp. )(DBY31_07615) 29 miltadfettteaparvwaiglceianpdifiygnsidwlfdwlinseeshtlyfhnlrfdgqfilfylfthgyewtdeknlkqgqfktlisdmgmfysitvcfedggkddkkevtfldslkilnfsvkqiakgfglpimkgeidykaerpvghiltqeevdylrndvqivamalavlfkqglkkmtagsnafhdfkttfgkkhfekmfpipendkeirkaykggftylnpafaekevfdghvfdvnslypsvmyfkmmpfgvpvrftgryeddklyplyvqrikcqfelkpgkiptiqlkgnlafiptqylsdsgdeivemtltnvdlklffeqyevynieyldgfkfmgaydlfkdyidkwtavkigstktknaamrslaklmlnslygkfslnpkvqskvpyfdrvnkvvkyklgpeeerepiyipvgafitayarevtirasqaikdlsikkygkdmyiysdtdsihtllpvedvetiietsdtelgkwahesdfvagkflhqkcyceaeivsdeeyeslladeetrsrctifdgvktflkvtcagmssgcykyvtwenfrtgeafkgkllhnnveggailkevdftik
厚壁菌門細菌(Firmicutes bacterium ) (DBX59_10140) 30 mrsytfdfetttdpedcrvwaygiysidddryitdgnsiegfiewlecaanckgyfhnlgfdgvfiidhllksgwlwvgskqkatdrtfttlisdmnqvyqitlyftktryvtiqdslkiiplsveamakaygleirkgsidydeyrepgheitdderaylvndvaivakslrtffeqkltkmtagsnalfdykrrlgghrkfrnvfpllseeedafirkayrggftyvnpkfqgrdvgegivfdvnslypsvmaacdgqflpygkpvwfdgvpqpterhplwiacvlcsfkgrkehipclqlkgnmmfkqteyvedsqgrvcitvtnvdwelmnkqyhvwdvefiggymfhasphmfqdyvckwvdiknqatisgngglrslaklmlnslygkfatrttvksrkpvlvdgvvhyvdlepeqrdgvylpcgvfitsyaryktitsaqsvydrfiyadtdslhlvgtdipdcldvdavrlgawkhestfdhgkflraktyvehevgadeltvhvaglparchenvtlenfefgavyegnltarkvpggvvlyegtkeirs
節桿菌噬菌體安加利(Arthrobacter phage Anjali) 31 mrfipaflarfvgaimggrkqaqyvadfetttdpddcrvwayglanintadslwdveigpsihrffdrmseedsvcyfhnlkfdgefifwqlfkegyvhvkdrphrpgqfstlissmgsfysitvrwkngkktefrdslkklpysvavvakafnqpeqkgdldyaayrapghiptaaerayiaadvlivaralktqfdqgmtkltvgsdslaefkkitgtrlydklfpvlpdemdaeiraayrggftyadtrfrgkvtrggitydvnslypsvmydrvlpygepiyapglpsptreyplfivsltftaklkpghipciqvkgsshflateyqteitepvtisctnvdlelwedhydldilsynggwlfrgvsglftefidkwmdvkannegglralaklqlnalygkfgtnpnitpkepvydpdtntvrlvlgdeetkdpiytamacfvtayardvtiraaqdnyphfayadtdslhllidddpigldvdphklgawkreyrfeaglfvrakayierlpspthepedcplvgqdfgirdkhgewcrhvthvagmpdrigarltipdfqegkkfrgklqpkrvpggivledigftlkms
節桿菌噬菌體孟德爾(Arthrobacter phage Mendel) 32 mrfipaflarfvgaimggrkqaqyvadfetttdpddcrvwayglanintadslwdveigpsihrffdrmaeedsvcyfhnlkfdgefifwqlfkegyvhvkdrphragqfstlissmgsfysitvrwkngkktefrdslkklpysvavvakafnqpeqkgdldytayrapghiptaaerayiaadvlivaralktqfdqgmtkltvgsdslaefkkltgtrlydklfpvlpdemdaeiraayrggftyadtrfrgrvtrggitydvnslypsvmydrvlpygepiyapglpsptreyplfivsltftaklkpghipciqvkgsshflateyqteitepvtisctsvdlqlwedhydldilsynggwlfrgasgfftdfidkwmdvkanndgglralaklqlnslygkfgtnpnvtpkepvydpdtntvrlvlgdeetkdpiytamacfvtayardvtiraaqdnyphfayadtdslhllidddpigldvdphklgawkreyrfeaglfvrakayierlpspthdpedcpldrhgehcrhvthvaglpdrigayltiadfkegnrftgklqpkrvpggivledvgftmkms
短尾噬菌體屬(Podoviridae sp. ) 33 mkdsyiyaadfetttdasdcrvwawcctninepdnctigtsiesfnkhvnklgsviiyfhnlkfdgmflldywlrrgyihrtdkelndnefstlisdsgqwyamkqriksniveyrdslkiipipieefsktfnipeqkleinysefrcvnhelteaeinyiksdtiilakalkimisrgfnrltcgsnayynyksmtpgfsklfpvlaqyvdrdirksykggwtylnkeyrnkkvfsgevydvnsmypwamkycalpygnpvrfsgeykkseiynlyvveiecefklkkgkfpsiqiknsifyseteyieesedittliltsvdlelffecydvniykwcggyafkskvglfsdyidywyniksqskidgnkgyefiakrmlnslygkygsrgegrskipylddgvvrfklselenrkagyvpvasfitsycrdkiiraansigsrfiyadtdsihilagekpnidideyrlgafklesrfirakfirqktymeiddcvdvngnhielknikcagmpkkiqkrvdeidfcegsvfngkllpevvpggvilkettfeikgskks
*歸因於基因在宏基因體鳥槍定序中之不完全序列覆蓋,序列資訊未知
聚合酶具有各種特徵,包括持續效力。聚合酶持續效力一般係指聚合酶將dNTP連續併入至核酸模板中而不釋放核酸模板之能力。在目標核酸之核鹼基與互補dNTP之間鹼基配對後,聚合酶藉由在新合成的股之3'羥基端與dNTP之α磷酸酯之間形成磷酸二酯鍵將dNTP併入新合成的核酸股中。藉由在單一締合/解離事件上由聚合酶併入之核苷酸之平均數量來確定持續效力。
聚合酶之持續效力變化。舉例而言,聚合酶可呈現相對於另一聚合酶之較高持續效力。替代地,相對於另一聚合酶,聚合酶可呈現降低的持續效力。類似地,聚合酶可在第一條件(例如包含核苷酸之第一組合)中呈現較高持續效力且在第二條件(例如包含核苷酸之第二組合)中呈現降低的持續效力。
聚合酶之其他特徵包括但不限於合成精確度、核酸酶活性、核苷酸受質利用率、核酸親和力、複製能力、平均讀段長度產生率、表面電荷及穩定性。類似於持續效力,此等特徵在聚合酶之間及在反應條件之間變化。
聚合酶特徵可藉由在聚合酶之胺基酸序列中引入修飾(或變化)來改變。舉例而言,在一些實施例中,藉由修飾增加(或替代地降低)聚合酶之持續效力。在一些實施例中,聚合酶之核酸酶活性藉由修飾而增加(或替代地降低)。在一些實施例中,聚合酶之(一或多個受質之)核苷酸受質利用率藉由修飾增加(或替代地降低)。在一些實施例中,聚合酶對一或多個受質之親和力藉由修飾而增加(或替代地降低)。在一些實施例中,聚合酶之複製能力藉由修飾增加(或替代地降低)。在一些實施例中,聚合酶之平均讀段長度藉由修飾增加(或替代地減少)。在一些實施例中,聚合酶之表面電荷藉由修飾變得更呈陽性(或替代地更呈陰性)。在一些實施例中,藉由修飾增加(或替代地降低)聚合酶之穩定性。在一些實施例中,聚合酶之一或多個特徵(例如,持續效力、核酸酶活性、核苷酸受質利用率、對一或多個受質之親和力、複製能力、平均讀段長度、表面電荷、穩定性等)增加約5%-10%、10%-20%、20%-30%、30%-40%、40%-50%、50%-60%、60%-70%、70%-80%、80%-90%、90%-100%或更多。在一些實施例中,聚合酶之一或多個特徵(例如,持續效力、核酸酶活性、核苷酸受質利用率、對一或多個受質之親和力、複製能力、平均讀段長度、表面電荷、穩定性等)增加超過約5%、超過約10%、超過約20%、超過約30%、超過約40%、超過約50%、超過約60%、超過約70%、超過約80%、超過約90%、超過約100%或更多。在一些實施例中,聚合酶之一或多個特徵(例如,持續效力、核酸酶活性、核苷酸受質利用率、對一或多個受質之親和力、複製能力、平均讀段長度、表面電荷、穩定性等)降低約5%-10%、10%-20%、20%-30%、30%-40%、40%-50%、50%-60%、60%-70%、70%-80%、80%-90%、90%-100%或更多。在一些實施例中,聚合酶之一或多個特徵(例如,持續效力、核酸酶活性、核苷酸受質利用率、對一或多個受質之親和力、複製能力、平均讀段長度、表面電荷、穩定性等)降低超過約5%、超過約10%、超過約20%、超過約30%、超過約40%、超過約50%、超過約60%、超過約70%、超過約80%、超過約90%。在一些實施例中,可消除一或多個特徵。
當將修飾引入到聚合酶之胺基酸序列中時,產生「經修飾聚合酶(modified polymerase)」(在本文中亦稱為「經修飾聚合酶(modified polymerizing enzyme)」,或當以重組方式產生時,稱為「經修飾重組聚合酶(modified recombinant polymerase)」)。修飾可包含一或多個胺基酸之缺失、一或多個胺基酸之添加、一或多個胺基酸之取代或其組合。經修飾聚合酶相對於野生型聚合酶(例如表1之序列,例如SEQ ID NO: 1、SEQ ID NO: 2-5、SEQ ID NO: 6-22或SEQ ID NO: 23-33)或相對於表2-7中任一者中所描述之序列,可包括一或多個修飾(例如,如此申請案中所述之一或多個胺基酸之缺失、一或多個胺基酸之添加、一或多個胺基酸之取代,或其組合)。舉例而言,在一些實施例中,修飾包含至少以下數目個胺基酸(其可為或可不為連續胺基酸)之缺失、添加或取代:至少1個、至少2個、至少3個、至少4個、至少5個、至少6個、至少7個、至少8個、至少9個、至少10個、至少11個、至少12個、至少13個、至少14個、至少15個、至少16個、至少17個、至少18個、至少19個、至少20個、至少21個、至少22個、至少23個、至少24個、至少25個、至少26個、至少27個、至少28個、至少29個、至少30個、至少31個、至少32個、至少33個、至少34個、至少35個、至少36個、至少37個、至少38個、至少39個、至少40個、至少41個、至少42個、至少43個、至少44個、至少45個、至少46個、至少47個、至少48個、至少49個、至少50個、至少55個、至少60個、至少70個、至少75個、至少80個、至少85個、至少90個、至少95個、至少100個、至少110個、至少120個、至少130個、至少140個或至少150個。在一些實施例中,修飾包含以下數目個胺基酸(其可為或可不為連續胺基酸)之缺失、添加或取代:1個、2個、3個、4個、5個、6個、7個、8個、9個、10個、11個、12個、13個、14個、15個、16個、17個、18個、19個、20個、21個、22個、23個、24個、25個、26個、27個、28個、29個、30個、31個、32個、33個、34個、35個、36個、37個、38個、39個、40個、41個、42個、43個、44個、45個、46個、47個、48個、49個、50個、51個、52個、53個、54個、55個、56個、57個、58個、59個、60個、61個、62個、63個、64個、65個、66個、67個、68個、69個、70個、71個、72個、73個、74個、75個、76個、77個、78個、79個、80個、81個、82個、83個、84個、85個、86個、87個、88個、89個、90個、91個、92個、93個、94個、95個、96個、97個、98個、99個、100個、105個、110個、115個、120個、125個、130個、140個或150個。
在一些實施例中,經修飾聚合酶包含一或多個非天然胺基酸取代。如本文所用,「非天然胺基酸」係指除了以下二十種基因編碼的α胺基酸之外的任何胺基酸、經修飾胺基酸或胺基酸類似物:丙胺酸、精胺酸、天冬醯胺、天冬胺酸、半胱胺酸、麩醯胺酸、麩胺酸、甘胺酸、組胺酸、異白胺酸、白胺酸、離胺酸、甲硫胺酸、苯丙胺酸、脯胺酸、絲胺酸、蘇胺酸、色胺酸、酪胺酸、纈胺酸。在一些實施例中,非天然胺基酸可包括除了上述二十種α胺基酸之外的天然存在化合物。非天然胺基酸及非天然胺基酸併入至蛋白質序列中之方法係此項技術中已知的,例如,如美國專利第7,045,337號中所述,其內容以引用之方式併入本文中。
A. 胺基酸修飾指定 修飾可由胺基酸序列內之位置指定。舉例而言,修飾可指定為「A484」,指示在聚合酶之胺基酸序列中之位置484處之丙胺酸殘基已經修飾(由此產生經修飾聚合酶)。修飾亦可藉由參考聚合酶之對應胺基酸之位置/一致性指定。
舉例而言,在一些實施例中,經修飾聚合酶包含對應於Φ29聚合酶(SEQ ID NO: 1)中之A484的位置處的突變。對應於其他聚合酶中之A484的胺基酸可藉由本領域中已知之任何方法(包括同源性比對)來測定。參見例如圖5B及圖17。
作為此分析之非限制性實例,同源性比對使用多個表1中所報告之聚合酶進行,且確定Φ29聚合酶中之A484對應於M2Y中之A481、芽孢桿菌噬菌體VMY22中之A492、屎腸球菌中之K500及銅綠蠅中之K827。相應地,可使用同源性比對及此項技術中已知之相似方法鑑別對應於本文中所描述之經修飾殘基之位置的其他聚合酶中之胺基酸。因此,應瞭解,本發明之修飾不意欲限於本文中所描述之聚合酶(例如表1中所列之聚合酶)且可延長至使用已知技術之任何聚合酶。
在一些實施例中,經修飾聚合酶之序列不包含一或多個對應於參考聚合酶(例如表1中所列之聚合酶)中之位置的胺基酸(亦即一或多個「同源胺基酸」)。因此,在一些實施例中,聚合酶藉由添加(或插入)指定參考位置處之同源胺基酸來修飾,該參考位置基於經修飾聚合酶之周圍同源殘基推斷。包含同源胺基酸之突變聚合酶變異體根據本文所述之實施例經工程改造且列於表3中。
(i)參考屎腸球菌聚合酶之胺基酸修飾 . 在一些實施例中,對聚合酶(例如表1中所列之聚合酶)進行胺基酸修飾,其中參考屎腸球菌聚合酶(SEQ ID NO: 2-5)進行胺基酸修飾。舉例而言,在一些實施例中,經修飾聚合酶包含對應於以下之一或多個位置處(例如在1-117個位置處,或在例如2個或更多個、5個或更多個、10個或更多個、15個或更多個、20個或更多個之間的任何整數(例如所有),以及其任何組合)之胺基酸修飾(亦即突變):屎腸球菌聚合酶(SEQ ID NO: 2)中之K4、T13、S22、V25、C26、D27、N33、I34、F36、S42、D54、N59、E60、E65、E85、M95、N106、T110、T114、K119、Q122、Y133、P136、E139、E142、N145、P147、I148、E152、I153、P160、D167、D171、N175、F188、D189、Q206、T211、S216、R217、D232、A236、V247、I253、V261、L264、S267、P273、P275、R308、V315、Q317、S319、L320、I322、Q323、D337、E338、D341、T345、F352、F353、T364、D374、I384、E385、N388、E391、A396、N397、G400、D414、D425、R429、E436、L437、V443、L445、A446、S447、V449、T450、W452、G453、Y455、F465、N467、T479、E482、A484、E485、A486、L490、D492、S493、K495、K500、S503、Q506、Q513、E519、D521、E523、V526、D533、R534、E537、G547、E545、L555、P556、R558、T559、V564、T568、M569及T571。
此類修飾可包含缺失(例如在對應於以下之位置處之胺基酸缺失:屎腸球菌聚合酶(SEQ ID NO: 2)中之K4、T13、S22、V25、C26、D27、N33、I34、F36、S42、D54、N59、E60、E65、E85、M95、N106、T110、T114、K119、Q122、Y133、P136、E139、E142、N145、P147、I148、E152、I153、P160、D167、D171、N175、F188、D189、Q206、T211、S216、R217、D232、A236、V247、I253、V261、L264、S267、P273、P275、R308、V315、Q317、S319、L320、I322、Q323、D337、E338、D341、T345、F352、F353、T364、D374、I384、E385、N388、E391、A396、N397、G400、D414、D425、R429、E436、L437、V443、L445、A446、S447、V449、T450、W452、G453、Y455、F465、N467、T479、E482、A484、E485、A486、L490、D492、S493、K495、K500、S503、Q506、Q513、E519、D521、E523、V526、D533、R534、E537、G547、E545、L555、P556、R558、T559、V564、T568、M569或T571 (或其任何組合))。
替代地或另外,此類修飾可包含添加(例如,在對應於以下之位置處添加同源胺基酸:屎腸球菌聚合酶(SEQ ID NO: 2)中之K4、T13、S22、V25、C26、D27、N33、I34、F36、S42、D54、N59、E60、E65、E85、M95、N106、T110、T114、K119、Q122、Y133、P136、E139、E142、N145、P147、I148、E152、I153、P160、D167、D171、N175、F188、D189、Q206、T211、S216、R217、D232、A236、V247、I253、V261、L264、S267、P273、P275、R308、V315、Q317、S319、L320、I322、Q323、D337、E338、D341、T345、F352、F353、T364、D374、I384、E385、N388、E391、A396、N397、G400、D414、D425、R429、E436、L437、V443、L445、A446、S447、V449、T450、W452、G453、Y455、F465、N467、T479、E482、A484、E485、A486、L490、D492、S493、K495、K500、S503、Q506、Q513、E519、D521、E523、V526、D533、R534、E537、G547、E545、L555、P556、R558、T559、V564、T568、M569或T571 (或其任何組合))。
替代地或另外,此類修飾可包含取代。舉例而言,修飾可包含對應於以下之一或多個位置處(例如在1-117個位置處,或在例如2個或更多個、5個或更多個、10個或更多個、15個或更多個、20個或更多個之間的任何整數(例如所有),以及其任何組合)之取代:屎腸球菌聚合酶(SEQ ID NO: 2)中之K4、T13、S22、V25、C26、D27、N33、I34、F36、S42、D54、N59、E60、E65、E85、M95、N106、T110、T114、K119、Q122、Y133、P136、E139、E142、N145、P147、I148、E152、I153、P160、D167、D171、N175、F188、D189、Q206、T211、S216、R217、D232、A236、V247、I253、V261、L264、S267、P273、P275、R308、V315、Q317、S319、L320、I322、Q323、D337、E338、D341、T345、F352、F353、T364、D374、I384、E385、N388、E391、A396、N397、G400、D414、D425、R429、E436、L437、V443、L445、A446、S447、V449、T450、W452、G453、Y455、F465、N467、T479、E482、A484、E485、A486、L490、D492、S493、K495、K500、S503、Q506、Q513、E519、D521、E523、V526、D533、R534、E537、G547、E545、L555、P556、R558、T559、V564、T568、M569及T571。在一些實施例中,取代係選自由以下組成之群:K4R、T13N、S22A、V25L、C26W、D27E、N33T、I34V、F36V、S42T、D54Y、N59D、E60L、E60V、E65S、E85P、M95T、M95K、N106G、T110I、T114S、K119Q、Q122V、Y133L、P136T、E139K、E139Q、E139R、E139H、E142K、E142Q、E142R、E142H、N145K、N145H、N145R、P147Q、P147T、I148K、I148H、I148R、E152D、I153V、P160A、D167P、D167K、D167H、D167R、D171K、D171H、D171R、N175T、N175Y、F188C、D189K、D189H、D189R、Q206R、Q206K、Q206H、T211A、S216G、S216R、R217G、D232K、A236G、V247D、I253H、I253A、V261A、V261I、V261L、L264H、L264A、L264M、S267A、P273S、P273R、P275S、E283K、V315L、S319R、R308G、G308R、Q317R、S319R、L320M、L320T、I322K、Q323G、Q323V、Q323R、D337G、E338K、D341T、T345I、F352I、F353C、T364I、D374G、D374Q、D374H、I384T、I384F、I384S、E385Y、E385K、E385R、E385N、E385Q、E385L、E385A、N388T、E391Y、E391W、E391F、E391H、E391M、E391K、E391R、A396Q、N397L、G400L、D414V、D425N、R429G、E436R、E436G、L437Y、L437E、V443T、L445M、A446G、S447V、V449I、T450A、W452Y、G453A、Y455W、F465Y、N467R、N467K、N467H、N467S、N467T、T479V、E482K、E482H、E482R、A484E、E485D、A486E、L490M、D492H、D492K、D492R、D492A、H492S、S493P、K495R、K500E、S503A、S503T、Q506K、Q513D、D521K、D521R、D521H、E523R、E523V、E523Y、E523F、E523H、E523W、V526L、D533A、D533Q、D533T、D533R、D533S、R534K、E537K、E537H、E537R、E545K、E545H、E545R、G547S、L555K、L555R、P556A、R558H、T559V、V564L、T568D、T568S、M569K、M569T、M569V及T571S (對應於屎腸球菌聚合酶(SEQ ID NO: 2)中之位置)。
例示性修飾組合列於表7中。
(ii)參考 Φ 29 聚合酶之胺基酸修飾。 在一些實施例中,對聚合酶(例如表1中所列之聚合酶)進行胺基酸修飾,其中參考Φ29聚合酶(SEQ ID NO: 1)進行胺基酸修飾。例如,在一些實施例中,經修飾聚合酶包含對應於以下一或多個位置(例如,2個或更多個、5個或更多個、10個或更多個、15個或更多個、20個或更多個,例如1、2、3、4、5、6、7、8、9、10、11、12、13、14、15、16、17、18、19、20、21、22、23、24、25、26、27、28、29、30、31、32、33、34、35、36、37、38、39、40、41、42、43或44個位置,以其任何組合形式)處之胺基酸修飾(亦即突變):Φ29聚合酶中之M8、V51、N62、I71、L107、K131、K135、L142、G135、L142、Y148、G197、Y224、Y226、E239、V250、N251、L253、Y281、I288、T301、R306、R308、D325、D341、K354、T368、E375、K379、Q380、A437、A444、P447、E466、D476、K478、A484、E508、D510、K512、E515、K539、D570或T571。
此類修飾可包含缺失(例如在對應於以下之位置處之胺基酸缺失:Φ29聚合酶中之M8、V51、N62、I71、L107、K131、K135、L142、G135、L142、Y148、G197、Y224、Y226、E239、V250、N251、L253、Y281、I288、T301、R306、R308、D325、D341、K354、T368、E375、K379、Q380、A437、A444、P447、E466、D476、K478、A484、E508、D510、K512、E515、K539、D570或T571 (或其任何組合))。
替代地或另外,此類修飾可包含添加(例如,在對應於以下之位置處添加同源胺基酸:Φ29聚合酶中之M8、V51、N62、I71、L107、K131、K135、L142、G135、L142、Y148、G197、Y224、Y226、E239、V250、N251、L253、Y281、I288、T301、R306、R308、D325、D341、K354、T368、E375、K379、Q380、A437、A444、P447、E466、D476、K478、A484、E508、D510、K512、E515、K539、D570或T571 (或其任何組合))。
替代地或另外,此類修飾可包含取代。舉例而言,修飾可包含對應於以下之一或多個位置處(例如在1-44個位置處,或在例如2個或更多個、5個或更多個、10個或更多個、15個或更多個、20個或更多個之間的任何整數(例如所有),以及其任何組合)之取代:Φ29聚合酶中之M8、V51、N62、I71、L107、K131、K135、L142、G135、L142、Y148、G197、Y224、Y226、E239、V250、N251、L253、Y281、I288、T301、R306、R308、D325、D341、K354、T368、E375、K379、Q380、A437、A444、P447、E466、D476、K478、A484、E508、D510、K512、E515、K539、D570及T571。在一些實施例中,取代係選自由以下組成之群:M8R、V51A、N62D、I71V、L107I、K131E、K135Q、L142K、Y148I、G197D、Y224K、Y226F、E239G、V250A、V250I、N251R、L253A、L253H、Y281H、I288L、T301C、R306Q、R308L、D325E、D341E、K354R、T368F、E375K、E375Y、K379R、Q380R、A437G、A444T、E466K、D476H、P477D、K478D、A484C、A484Q、A484N、A484E、A484D、A484K、A484R、A484H、A484Y及A484X (其中X表示非天然胺基酸,如本文所述)、E508R、D510K、D510R、K512Y、E515Q、K539E、D570S及T571V (對應於Φ29聚合酶中之位置)。
在一些實施例中,經修飾聚合酶包含對應於以下之位置處的一或多個(例如2個或更多個、5個或更多個、10個或更多個、15個或更多個、20個或更多個,例如全部)胺基酸突變:Φ29聚合酶中之K131、K135、L142、Y148、Y224、E239、V250、L253、R306、R308、E375、A437、E466、D476、A484、E508、D510、K512、E515、K539、D570及T571。
B. 多數聚合酶序列 在一些實施例中,由本發明提供之經修飾聚合酶包含根據野生型聚合酶序列(例如如表1中所述)之聚合酶序列,其具有一或多個修飾(例如如表2-6中所例示,或其兩者或更多者之組合)。在一些實施例中,野生型聚合酶胺基酸序列(例如如表1中所述)提供大多數聚合酶序列,其中可進行一或多個修飾以產生經修飾聚合酶。如本文所用,經修飾聚合酶之「大多數聚合酶序列」或「大多數序列」係指在經修飾聚合酶胺基酸序列內占絕大多數之野生型聚合酶胺基酸序列(例如,其中經修飾聚合酶序列中之至少50%胺基酸對應於大多數序列中之胺基酸)。在一些實施例中,經修飾聚合酶序列包含進一步包含一或多個胺基酸突變的大多數序列。在一些實施例中,一或多個胺基酸突變包含對應於同源蛋白質中之位置的位置處的胺基酸。在一些實施例中,表2-6中之任一者中所述之聚合酶胺基酸序列提供大多數聚合酶序列,其中可進行一或多個修飾以產生經修飾聚合酶。
在一些實施例中,經修飾聚合酶具有與表1中所列之一或多個聚合酶(例如與表1中所列之SEQ ID NO: 1、SEQ ID NO: 2-5、SEQ ID NO: 6-22或SEQ ID NO: 23-33)之至少25%胺基酸序列一致性。在一些實施例中,經修飾聚合酶具有與表1中所列之聚合酶中之一或多者(例如與表1中所列之SEQ ID NO: 1、SEQ ID NO: 2-5、SEQ ID NO: 6-22或SEQ ID NO: 23-33)之25-50%、50-60%、60-70%、70-80%、80-90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或更高之胺基酸序列一致性。在一些實施例中,經修飾聚合酶具有與SEQ ID No: 2-5中之任一者之25-50%、50-60%、60-70%、70-80%、80-90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或更高之胺基酸序列一致性。在一些實施例中,經修飾聚合酶具有與SEQ ID NO: 2之25-50%、50-60%、60-70%、70-80%、80-90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或更高之胺基酸序列一致性。在一些實施例中,經修飾聚合酶具有與SEQ ID NO: 23-33中之任一者之25-50%、50-60%、60-70%、70-80%、80-90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或更高之胺基酸序列一致性。在一些實施例中,此類經修飾聚合酶包括一或多個在此申請案中所提供之不同經修飾聚合酶組態及/或實例之內容中所描述之胺基酸突變及/或域取代。在一些實施例中,經修飾聚合酶中之唯一修飾為本發明中所提供之修飾(例如胺基酸取代)中之一或多者,且聚合酶之序列另外與野生型聚合酶(例如表1之序列)或與表2-7中之任一者所描述之序列一致。
序列一致性可參考經修飾聚合酶之整個胺基酸序列。然而,在一些實施例中,序列一致性係關於經修飾聚合酶之一或多個區段、子域或域。舉例而言,在一些實施例中,經修飾聚合酶之一或多個區段、子域或域描述為具有與表1中所列之參考聚合酶之區段、子域或域(例如與表1中所列之SEQ ID NO: 1、SEQ ID NO: 2-5、SEQ ID NO: 6-22或SEQ ID NO: 23-33)之至少50%胺基酸序列一致性。此類區段、子域或域可具有與表1中所列之參考聚合酶之對應區段、子域或域(例如與表1中所列之SEQ ID NO: 1、SEQ ID NO: 2-5、SEQ ID NO: 6-22或SEQ ID NO: 23-33)之例如50-60%、60-70%、70-80%、80-90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%之序列一致性。在一些實施例中,此類區段、子域或域可具有與SEQ ID No: 2-5中之任一者之相對應區段、子域或域之例如50-60%、60-70%、70-80%、80-90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%之序列一致性。在一些實施例中,此類區段、子域或域可具有與SEQ ID NO: 2之對應區段、子域或域之例如50-60%、60-70%、70-80%、80-90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%之序列一致性。在一些實施例中,此類區段、子域或域可具有與SEQ ID No: 23-33中之任一者之相對應區段、子域或域之例如50-60%、60-70%、70-80%、80-90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%之序列一致性。
出於比較兩個或更多個胺基酸序列之目的,第一胺基酸序列與第二胺基酸序列之間的「序列一致性」百分比(在本文中亦稱為「胺基酸一致性」)可藉由將[第一胺基酸序列中與第二胺基酸序列中對應位置處之胺基酸殘基一致之胺基酸殘基的數目]除以[第一胺基酸序列中胺基酸殘基之總數目]且乘以[100%]來計算,其中與第一胺基酸序列相比第二胺基酸序列中胺基酸殘基之缺失、插入、取代或添加各者均視為單一胺基酸殘基(位置)處之差異,亦即如本文所定義之「胺基酸差異」。替代地,兩個胺基酸序列之間之序列一致性程度可使用已知電腦算法(例如藉由Smith及Waterman (1970) Adv. Appl. Math. 2:482c之局部同源性算法,藉由Needleman及Wunsch, J. Mol. Biol. (1970) 48:443之同源性比對算法,藉由Pearson及Lipman. Proc. Natl. Acad. Sci. USA (1998) 85:2444之相似性方法之搜索,或藉由如Blast、Clustal Omega之可利用的算法或其他序列比對算法之電腦化實施方案)且例如使用標準設置來計算。通常,出於根據上文概述之計算方法測定兩個胺基酸序列之間之「序列一致性」之百分比之目的,具有最大胺基酸殘基數目之胺基酸序列將視為「第一」胺基酸序列且另一胺基酸序列將視為「第二」胺基酸序列。
另外或替代地,可針對序列間之一致性評定兩個或更多個序列。在兩個或更多個核酸或胺基酸序列之內容中之術語「一致」或「一致性」百分比係指相同的兩個或更多個序列或子序列。若當在比較窗上經比較及比對以達到最大對應度時在指定區域上或整個序列上,或如使用以下序列比對演算法中之一者或藉由手動比對及目視檢查所量測的指定區域上,兩個序列具有指定百分比之相同胺基酸殘基或核苷酸(例如至少80%、85%、90%、95%、96%、97%、98%、99%、99.5%、99.6%、99.7%、99.8%或99.9%一致),則兩個序列「實質上一致」。視情況,該一致性存在於長度為至少約25、50、75或100個胺基酸之區域上,或更佳長度為100至150、200或更多個胺基酸之區域上。
另外或替代地,可針對序列間之比對評定兩個或更多個序列。在兩個或更多個核酸或胺基酸序列之內容中之術語「比對」或「比對」百分比係指相同的兩個或更多個序列或子序列。若當在比較窗上經比較及比對以達到最大對應時在指定區域上或整個序列上,或如使用以下序列比對演算法中之一者或藉由手動比對及目視檢查所量測的指定區域上,兩個序列具有指定百分比之相同胺基酸殘基或核苷酸(例如至少80%、85%、90%、95%、96%、97%、98%、99%、99.5%、99.6%、99.7%、99.8%或99.9%一致),則兩個序列「實質上比對」。視情況,該比對存在於長度為至少約25、50、75或100個胺基酸之區域上,或更佳長度為100至150、200或更多個胺基酸之區域上。
(i)經修飾屎腸球菌聚合酶 本申請案部分地基於認識到,來自屎腸球菌之聚合酶可有利地用作活體外聚合反應中之試劑,諸如單分子核酸定序反應。本發明人已認識到,野生型屎腸球菌聚合酶顯示穩固股置換活性、對核苷酸受質(例如超過70千鹼基)之較高持續效力以及利用合成核苷酸類似物之能力。圖24展示來自評定相比於已知前進型聚合酶QTDE1.0之野生型EF聚合酶之持續效力的滾環分析之結果。本發明人已進一步認識到,對野生型屎腸球菌聚合酶之某些修飾(例如突變、插入及/或取代)進一步增強此等及其他功能屬性以提供用於核酸定序反應之改良試劑。因此,在一些實施例中,經修飾聚合酶為經修飾屎腸球菌聚合酶(亦即,包含屎腸球菌聚合酶大多數序列,諸如SEQ ID NO: 2-5中之任一者)。圖13A展示四種天然存在屎腸球菌聚合酶變異體之間的序列一致性。圖13B展示變異體之間共有的序列一致性。序列藉由其NCBI蛋白質資料庫寄存編號列出。在一些實施例中,經修飾聚合酶包含屎腸球菌聚合酶大多數序列SEQ ID NO: 2。
在一些實施例中,經修飾屎腸球菌聚合酶包含對應於一下之一或多個位置處(例如在1-117個位置處,或在例如2個或更多個、5個或更多個、10個或更多個、15個或更多個、20個或更多個之間的任何整數(例如所有),以及其任何組合)之胺基酸修飾(亦即突變):參考屎腸球菌聚合酶之K4、T13、S22、V25、C26、D27、N33、I34、F36、S42、D54、N59、E60、E65、E85、M95、N106、T110、T114、K119、Q122、Y133、P136、E139、E142、N145、P147、I148、E152、I153、P160、D167、D171、N175、F188、D189、Q206、T211、S216、R217、D232、A236、V247、I253、V261、L264、S267、P273、P275、R308、V315、Q317、S319、L320、I322、Q323、D337、E338、D341、T345、F352、F353、T364、D374、I384、E385、N388、E391、A396、N397、G400、D414、D425、R429、E436、L437、V443、L445、A446、S447、V449、T450、W452、G453、Y455、F465、N467、T479、E482、A484、E485、A486、L490、D492、S493、K495、K500、S503、Q506、Q513、E519、D521、E523、V526、D533、R534、E537、G547、E545、L555、P556、R558、T559、V564、T568、M569及T571。經修飾屎腸球菌聚合酶可包含一或多個相對於SEQ ID No: 2-5之胺基酸修飾或表2或表7中所述之序列。
此類修飾可包含缺失(例如在對應於以下之位置處之胺基酸缺失:參考屎腸球菌聚合酶中之K4、T13、S22、V25、C26、D27、N33、I34、F36、S42、D54、N59、E60、E65、E85、M95、N106、T110、T114、K119、Q122、Y133、P136、E139、E142、N145、P147、I148、E152、I153、P160、D167、D171、N175、F188、D189、Q206、T211、S216、R217、D232、A236、V247、I253、V261、L264、S267、P273、P275、R308、V315、Q317、S319、L320、I322、Q323、D337、E338、D341、T345、F352、F353、T364、D374、I384、E385、N388、E391、A396、N397、G400、D414、D425、R429、E436、L437、V443、L445、A446、S447、V449、T450、W452、G453、Y455、F465、N467、T479、E482、A484、E485、A486、L490、D492、S493、K495、K500、S503、Q506、Q513、E519、D521、E523、V526、D533、R534、E537、G547、E545、L555、P556、R558、T559、V564、T568、M569或T571 (或其任何組合))。
替代地或另外,此類修飾可包含添加(例如,在對應於以下之位置處添加同源胺基酸:參考屎腸球菌聚合酶中之K4、T13、S22、V25、C26、D27、N33、I34、F36、S42、D54、N59、E60、E65、E85、M95、N106、T110、T114、K119、Q122、Y133、P136、E139、E142、N145、P147、I148、E152、I153、P160、D167、D171、N175、F188、D189、Q206、T211、S216、R217、D232、A236、V247、I253、V261、L264、S267、P273、P275、R308、V315、Q317、S319、L320、I322、Q323、D337、E338、D341、T345、F352、F353、T364、D374、I384、E385、N388、E391、A396、N397、G400、D414、D425、R429、E436、L437、V443、L445、A446、S447、V449、T450、W452、G453、Y455、F465、N467、T479、E482、A484、E485、A486、L490、D492、S493、K495、K500、S503、Q506、Q513、E519、D521、E523、V526、D533、R534、E537、G547、E545、L555、P556、R558、T559、V564、T568、M569或T571 (或其任何組合))。
替代地或另外,此類修飾可包含取代。舉例而言,修飾可包含對應於以下之一或多個位置處(例如在1-117個位置處,或在例如2個或更多個、5個或更多個、10個或更多個、15個或更多個、20個或更多個之間的任何整數(例如所有),以及其任何組合)之取代:屎腸球菌聚合酶中之K4、T13、S22、V25、C26、D27、N33、I34、F36、S42、D54、N59、E60、E65、E85、M95、N106、T110、T114、K119、Q122、Y133、P136、E139、E142、N145、P147、I148、E152、I153、P160、D167、D171、N175、F188、D189、Q206、T211、S216、R217、D232、A236、V247、I253、V261、L264、S267、P273、P275、R308、V315、Q317、S319、L320、I322、Q323、D337、E338、D341、T345、F352、F353、T364、D374、I384、E385、N388、E391、A396、N397、G400、D414、D425、R429、E436、L437、V443、L445、A446、S447、V449、T450、W452、G453、Y455、F465、N467、T479、E482、A484、E485、A486、L490、D492、S493、K495、K500、S503、Q506、Q513、E519、D521、E523、V526、D533、R534、E537、G547、E545、L555、P556、R558、T559、V564、T568、M569及T571。在一些實施例中,取代係選自由以下組成之群:K4R、T13N、S22A、V25L、C26W、D27E、N33T、I34V、F36V、S42T、D54Y、N59D、E60L、E60V、E65S、E85P、M95T、M95K、N106G、T110I、T114S、K119Q、Q122V、Y133L、P136T、E139K、E139Q、E139R、E139H、E142K、E142Q、E142R、E142H、N145K、N145H、N145R、P147Q、P147T、I148K、I148H、I148R、E152D、I153V、P160A、D167P、D167K、D167H、D167R、D171K、D171H、D171R、N175T、N175Y、F188C、D189K、D189H、D189R、Q206R、Q206K、Q206H、T211A、S216G、S216R、R217G、D232K、A236G、V247D、I253H、I253A、V261A、V261I、V261L、L264H、L264A、L264M、S267A、P273S、P273R、P275S、E283K、V315L、S319R、R308G、G308R、Q317R、S319R、L320M、L320T、I322K、Q323G、Q323V、Q323R、D337G、E338K、D341T、T345I、F352I、F353C、T364I、D374G、D374Q、D374H、I384T、I384F、I384S、E385Y、E385K、E385R、E385N、E385Q、E385L、E385A、N388T、E391Y、E391W、E391F、E391H、E391M、E391K、E391R、A396Q、N397L、G400L、D414V、D425N、R429G、E436R、E436G、L437Y、L437E、V443T、L445M、A446G、S447V、V449I、T450A、W452Y、G453A、Y455W、F465Y、N467R、N467K、N467H、N467S、N467T、T479V、E482K、E482H、E482R、A484E、E485D、A486E、L490M、D492H、D492K、D492R、D492A、H492S、S493P、K495R、K500E、S503A、S503T、Q506K、Q513D、D521K、D521R、D521H、E523R、E523V、E523Y、E523F、E523H、E523W、V526L、D533A、D533Q、D533T、D533R、D533S、R534K、E537K、E537H、E537R、E545K、E545H、E545R、G547S、L555K、L555R、P556A、R558H、T559V、V564L、T568D、T568S、M569K、M569T、M569V及T571S (對應於參考屎腸球菌聚合酶中之位置)。
例示性修飾組合列於表7中。
在一些實施例中,經修飾屎腸球菌聚合酶不包含對應於以下一或多個位置處(例如,2個或更多個、5個或更多個、10個或更多個、15個或更多個、20個或更多個,例如1、2、3、4、5、6、7、8、9、10、11、12、13、14、15、16、17、18、19、20、21、22、23、24、25、26、27、28、29、30、31、32、33、34、35、36、37、38、39、40、41、42、43或44個,以其任何組合形式)之胺基酸修飾(亦即突變):Φ29聚合酶(SEQ ID NO: 1)中之M8、V51、N62、I71、L107、K131、K135、L142、G135、L142、Y148、G197、Y224、Y226、E239、V250、N251、L253、Y281、I288、T301、R306、R308、D325、D341、K354、T368、E375、K379、Q380、A437、A444、P447、E466、D476、K478、A484、E508、D510、K512、E515、K539、D570或T571。
在一些實施例中,經修飾屎腸球菌聚合酶包含至少一種改變聚合酶相對於參考屎腸球菌聚合酶之特徵的修飾。舉例而言,修飾可使得:增加(或替代地降低)持續效力;增加(或替代地降低)核酸酶活性;增加(或替代地降低)精確度;增加(或替代地降低) (一或多個受質之)核苷酸受質利用率;增加(或替代地降低)對一或多個受質之親和力;增加(或替代地降低)複製能力;增加(或替代地降低)平均讀段長度;增加(或替代地降低)在表面處之正電性電荷。
在一些實施例中,經修飾屎腸球菌聚合酶包含一或多個改良持續效力的修飾。舉例而言,在一些實施例中,經修飾聚合酶包含對應於屎腸球菌聚合酶中之T568及M569之一或多個位置處的突變。在一些實施例中,本發明之經修飾聚合酶為包含T568及M569中之一者或兩者處之突變的經修飾屎腸球菌聚合酶。在一些實施例中,經修飾聚合酶包含以下中之一或多者:選自T568D及T568S的T568處之突變;及選自M569T及M569V的M569處之突變。在一些實施例中,經修飾屎腸球菌聚合酶包含T568及K500中之每一者處之突變。
在一些實施例中,經修飾屎腸球菌聚合酶包含消除或降低外切核酸酶活性之修飾。舉例而言,在一些實施例中,經修飾屎腸球菌聚合酶包含N59處之突變,其消除或降低外切核酸酶活性。在一些實施例中,經修飾屎腸球菌聚合酶包含N59D。在一些實施例中,經修飾屎腸球菌聚合酶不包含N59處之突變(例如經修飾屎腸球菌聚合酶包含N59)。應瞭解,視所需功能性而定,經修飾屎腸球菌聚合酶中N59處之突變可引入或恢復回野生型。相應地,在一些實施例中,經修飾屎腸球菌聚合酶包含選自表2之序列,其經進一步修飾以在N59處引入突變(例如經進一步修飾以包含N59D)。在一些實施例中,經修飾屎腸球菌聚合酶包含選自表2之序列,其經進一步修飾以使N59處之突變恢復回野生型(例如,經進一步修飾以包含D59N)。
在一些實施例中,經修飾屎腸球菌聚合酶包含一或多種修飾,其改良在活性位點處之核苷酸受質利用率。在一些實施例中,此類修飾增強聚合反應中核苷酸或核苷酸類似物(例如六磷酸核苷酸)至新合成核酸股中之併入。舉例而言,在一些實施例中,經修飾聚合酶包含在一或多個對應於屎腸球菌聚合酶中之V261、L264、S267、I384、E391、W452、G453、Y455、D492及K500之位置處的突變。在一些實施例中,本發明之經修飾聚合酶為包含在V261、L264、S267、I384、E391、W452、G453、Y455、D492及K500中之一或多者處之突變的經修飾屎腸球菌聚合酶。在一些實施例中,經修飾屎腸球菌聚合酶包含以下中之一或多者:選自V261A及V261I之V261處之突變;選自L264A、L264H及L264M之L264處之突變;S267A;選自I384F及I384S之I384處之突變;選自E391Y、E391W、E391F、E391H、E391M、E391K及E391R之E391處之突變;W452Y;G453A;Y455W;D492H;及K500E。在一些實施例中,本發明之經修飾聚合酶為包含在V261、L264、S267、I384、E391、W452、G453、Y455、D492及K500中之每一者處之突變的經修飾屎腸球菌聚合酶。在一些實施例中,經修飾屎腸球菌聚合酶包含V261A、L264H及K500E。
在一些實施例中,經修飾屎腸球菌聚合酶包含改良在活性位點處之核苷酸受質利用率的區段插入。舉例而言,基於結構同源性分析,確定野生型屎腸球菌聚合酶不含有接近如在Φ29聚合酶之掌型域中所發現之活性位點的結構基元。跨越Φ29序列中之D503至K525之此結構基元形成與核苷酸類似物(例如核苷酸六磷酸酯)之有利相互作用,從而改良定序反應中之效能。圖14A-14B展示屎腸球菌聚合酶與Φ29之比較。在一些實施例中,活性位點修飾包含用對應於Φ29聚合酶中之位置D503至K525之區段(例如包含跨越Φ29聚合酶中之D503至K525之序列的區段,或M2Y聚合酶中之同源區段)置換屎腸球菌聚合酶(E519至G522)中之位置519至522處之胺基酸的區段插入。在一些實施例中,區段插入包含一或多個在對應於Φ29聚合酶中之E508、D510、K512及E515Q之位置處的突變。在一些實施例中,區段插入包含選自E508R、D510R、K512Y及E515Q之一或多個突變。在一些實施例中,區段插入用包含胺基酸序列DIYAKRVRGYLIECSPDEATTTK (SEQ ID NO: 841)之區段置換屎腸球菌聚合酶(EIKG,SEQ ID NO: 840)中之位置519至522處之胺基酸。在一些實施例中,區段插入用包含胺基酸序列DIYMKRVRGYLVQGSPDDYTDIK (SEQ ID NO: 842)之區段置換屎腸球菌聚合酶(EIKG,SEQ ID NO: 840)中之位置519至522處之胺基酸。
在一些實施例中,經修飾屎腸球菌聚合酶包含一或多種提高聚合精確度之修飾。舉例而言,在一些實施例中,經修飾聚合酶包含在一或多個對應於以下之位置處的突變:屎腸球菌聚合酶中之E65、Y133、V261、L264、S267、I384、E391、G400、V443、L445、A446、S447、V449、T450、W452、G453、Y455、K500、S503、E523、L555及P556。在一些實施例中,本發明之經修飾聚合酶為包含在以下中之一或多者處之突變的經修飾屎腸球菌聚合酶:E65、Y133、V261、L264、S267、I384、E391、G400、V443、L445、A446、S447、V449、T450、W452、G453、Y455、K500、S503、E523、L555及P556。在一些實施例中,經修飾屎腸球菌聚合酶包含以下中之一或多者:E65S;Y133L;選自V261A及V261I之V261處之突變;選自L264A及L264H之L264處之突變;S267A;選自I384F、I384S之I384處之突變;選自E391Y、E391W、E391F及E391K之E391處之突變;G400L;V443T;L445M;A446G;S447V;V449I;T450A;W452Y;G453A、Y455W;K500E;S503A;選自E523K、E523Y、E523F、E523H及E523W之E523處之突變;L555K;及P556A。
在一些實施例中,經修飾屎腸球菌聚合酶包含一或多種增強DNA結合之修飾。舉例而言,在一些實施例中,經修飾聚合酶包含在一或多個對應於屎腸球菌聚合酶中之Q317、S319、I322、Q323、R429、L555及T559之位置處的突變。在一些實施例中,本發明之經修飾聚合酶為包含在Q317、S319、I322、Q323、R429、L555及T559中之一或多者處之突變的經修飾屎腸球菌聚合酶。在一些實施例中,經修飾聚合酶包含以下中之一或多者:Q317R;S319R;I322K;Q323G;R429G;L555K;及T559V。
在一些實施例中,經修飾屎腸球菌聚合酶包含一或多種增強類似物結合之修飾。舉例而言,在一些實施例中,經修飾聚合酶包含在一或多個對應於屎腸球菌聚合酶中之E391、S503及E523之位置處的突變。在一些實施例中,本發明之經修飾聚合酶為包含在E391、S503及E523中之一或多者處之突變的經修飾屎腸球菌聚合酶。在一些實施例中,經修飾聚合酶包含以下中之一或多者:在選自E391Y、E391W、E391F及E391K之E391處之突變;S503A;及在選自E523K、E523Y、E523F、E523H及E523W之E523處之突變。
在一些實施例中,經修飾屎腸球菌聚合酶包含一或多種增強股置換之修飾。舉例而言,在一些實施例中,經修飾聚合酶包含在一或多個對應於屎腸球菌聚合酶中之Q206、E436及L437之位置處的突變。在一些實施例中,本發明之經修飾聚合酶為包含在Q206、E436及L437中之一或多者處之突變的經修飾屎腸球菌聚合酶。在一些實施例中,經修飾聚合酶包含以下中之一或多者:選自Q206R、Q206K及Q206H之Q206處之突變;E436R;及選自L437Y及L437E之L437處之突變。
在一些實施例中,經修飾屎腸球菌聚合酶包含一或多種增強平均閱讀長度之修飾。舉例而言,在一些實施例中,經修飾聚合酶包含在一或多個對應於屎腸球菌聚合酶中之E436、L437、R534、T568及M569之位置處的突變。在一些實施例中,經修飾屎腸球菌聚合酶包含在E436、L437、R534、T568及M569中之一或多者處之突變。在一些實施例中,經修飾聚合酶包含以下中之一或多者:E436R;選自L437Y及L437E之L437處之突變;R534K;選自T568D及T568S之T568處之突變;及選自M569T及M569V之M569處之突變。
在一些實施例中,經修飾屎腸球菌聚合酶包含一或多種增強複製能力之修飾(例如在45℃下)。舉例而言,在一些實施例中,經修飾聚合酶包含在一或多個對應於以下之位置處之突變:屎腸球菌聚合酶中之T13、V25、C26、D27、N33、I34、F36、S42、D54、E60、M95、T110、T114、K119、P136、P147、E152、I153、P160、N175、F188、S216、R217、D232、A236、V247、P273、P275、E283、V315、S319、L320、Q323、E338、T345、F352、F353、T364、D414、D425、E436、F465、E485、A486、L490、S503、E523、V526、G547、L555、R558、V564、M569及T571。在一些實施例中,本發明之經修飾聚合酶為包含在以下中之一或多者處之突變的經修飾屎腸球菌聚合酶:T13、V25、C26、D27、N33、I34、F36、S42、D54、E60、M95、T110、T114、K119、P136、P147、E152、I153、P160、N175、F188、S216、R217、D232、A236、V247、P273、P275、E283、V315、S319、L320、Q323、E338、T345、F352、F353、T364、D414、D425、E436、F465、E485、A486、L490、S503、E523、V526、G547、L555、R558、V564、M569及T571。在一些實施例中,經修飾聚合酶包含以下中之一或多者:T13N;V25L;C26W;D27E;N33T;I34V;F36V;S42T;D54Y;E60V;選自M95T及M95K之位置M95處之突變;T110I;T114S;K119Q;P136T;選自P147Q及P147T之位置P147處之突變;E152D;I153V;P160A;N175Y;F188C;選自S216G及S216R之位置S216處之突變;R217G;D232H;A236G;V247D;P273R;P275S;E283K;V315L;S319R;選自L320M及L320T之位置L320處之突變;Q323R;E338K;T345I;F352I;F353C;T364I;D414V;D425N;E436G;F465Y;E485D;A486E;L490M;S503T;E523V;V526L;G547S;L555R;R558H;V564L;M569K;及T571S。
在一些實施例中,經修飾屎腸球菌聚合酶包含一或多個增加蛋白質表面處之正電性電荷的修飾。類似地,在一些實施例中,經修飾屎腸球菌聚合酶包含增加之等電點。在一些實施例中,經修飾屎腸球菌聚合酶具有滿足以下之等電點:高於野生型屎腸球菌聚合酶(例如SEQ ID NO: 2 )之等電點的0.1、0.2、0.3、0.4、0.5、0.6、0.7、0.8、0.9、1.0、1.0-1.5、1.5-2.0、2.0-2.5、2.5-3.0、3.0-3.5、3.5-4.0、4.0-4.5、5.0-5.5、5.5-6.0、6.0-6.5、6.5-7.0、7.0-7.5、7.5-8.0、8.0-8.5、8.5-9.0、9.0-9.5或9.5-10.0等電點(pI)單元。量測表面電荷及等電點之方法為一般熟習此項技術者所已知。等電點(pI)為熟習此項技術者熟悉之蛋白質生物化學中之標準概念。pI為蛋白質顯示淨電荷為零時之pH值。pI之增加意謂蛋白質顯示淨電荷為零需要較高pH值。因此,pI之增加表示在給定pH下蛋白質之淨正電荷之增加。測定蛋白質之pI之方法在此項技術中已知。舉例而言,蛋白質之pI可由蛋白質中所存在之各胺基酸之平均pKa值計算出(「經計算pI」)。該等計算可使用此項技術中已知之電腦程式(例如來自Scripps研究協會之蛋白質計算器及來自ExPASy之計算pI/MW工具)進行。應使用相同計算技術/程式進行不同分子之間pI值之比較。適當時,蛋白質之計算pI可使用等電聚焦技術以實驗方式證實(「經觀測pI」)。此技術根據其pI使用電泳來分離蛋白質。通常使用具有固定pH梯度之凝膠進行等電聚焦。當施加電場時,蛋白質經由pH梯度遷移直至其達到具有零淨電荷時之pH,此時為蛋白質之pI。藉由等電聚焦提供之結果可在本質上具有相對低解析度,且因此在一些實施例中,藉由計算pI (如上文所描述)提供之結果更適於使用。
在一些實施例中,此類表面電荷修飾藉由提供對核苷酸類似物更具吸引力之蛋白質表面來提高包含負電性組分(例如核酸連接子)之核苷酸類似物之併入率。在一些實施例中,經修飾聚合酶包含在一或多個對應於以下之位置處的突變:屎腸球菌聚合酶中之E139;E142;N145;I148;D167;D171;D189;D374;E385;E391;N467;E482;D492;K495;D521;E523;D533;E537及E545。在一些實施例中,本發明之經修飾聚合酶為包含在以下中之一或多者處之突變的經修飾屎腸球菌聚合酶:E139、E142、N145、I148、D167、D171、D189、D374、E385、E391、N467、E482、D492、K495、D521、E523、D533、E537及E545。在一些實施例中,經修飾聚合酶包含以下中之一或多者:選自E139K、E139Q、E139R及E139H之E139處之突變;選自E142K、E142H、E142R及E142Q之E142處之突變;選自N145K、N145H及N145R之N145處之突變;選自I148K、I148H及I148R之I148處之突變;選自D167P、D167K、D167H及D167R之D167處之突變;選自D171K、D171H及D171R之D171處之突變;選自D189K、D189H及D189R之D189處之突變;選自D374G、D374Q及D374H之D374處之突變;選自E385Y、E385K、E385R、E385N、E385Q、E385L及E385A之E385處之突變;選自E391Y、E391W、E391K及E391F之E391處之突變;選自N467R、N467K、N467H、N467S及N467T之N467處之突變;選自E482K、E482H及E482R之E482處之突變;選自D492H、D492K及D492R之D492處之突變;K495R;選自D521K、D521H及D521R之D521處之突變;選自E523K、E523Y、E523H、E523R、E523F及E523W之E523處之突變;選自D533A、D533Q、D533T、D533R及D533S之D533處之突變;選自E537K、E537H及E537R之E537處之突變;以及選自E545K、E545H及E545R之E545處之突變。
在一些實施例中,經修飾屎腸球菌聚合酶包含一或多種增強蛋白質穩定性(例如增強熱穩定性、蛋白質產率及/或活性聚合酶群體)之修飾。舉例而言,在一些實施例中,經修飾聚合酶包含在一或多個對應於以下中之位置處的突變:屎腸球菌聚合酶中之K4、S22、D27、I34、D54、E60、E85、M95、N106、T110、Q122、Y133、P136、P147、D167、T211、D232、P275、R308、S319、L320、E323、D337、E338、D341、T345、F352、T364、D414、F465、T479、E485、L490、S493、Q513及R558。在一些實施例中,本發明之經修飾聚合酶為包含在以下中之一或多者處之突變的經修飾屎腸球菌聚合酶:K4、S22、D27、I34、D54、E60、E85、M95、N106、T110、Q122、Y133、P136、P147、D167、T211、D232、P275、R308、S319、L320、Q323、D337、E338、D341、T345、F352、T364、D414、F465、T479、E485、L490、S493、Q513及R558。在一些實施例中,經修飾聚合酶包含以下中之一或多者:K4R;S22A;D27E;I34V;D54Y;選自E60V及E60L之E60處之突變;E85P;M95K;T110I;N106G;Q122V;Y133L;P136T;選自P147Q及P147T之P147處之突變;D167P;T211A;D232K;P275S;R308G;S319R;L320M;Q323V;D337G;E338K;D341T;T345I;F352I;T364I;D414V;F465Y;T479V;E485D;L490M;S493P;Q513D;及R558H。
在一些實施例中,經修飾屎腸球菌聚合酶包含一或多種增強聚合反應中之效能(例如藉由改良之精確度、增加之讀段長度及/或增加之速度)的修飾。在一些實施例中,經修飾聚合酶包含增強在一或多個對應於屎腸球菌聚合酶中之E142、V261、L264、S319、E391、L437、E482、D492、K500、E519、D521、E523、T568及M569之位置處的突變。在一些實施例中,經修飾屎腸球菌聚合酶包含在以下中之一或多者處之突變:E142、V261、L264、S319、E391、L437、E482、D492、K500、E519、D521、E523、T568及M569。在一些實施例中,經修飾聚合酶包含以下中之一或多者:選自E142K及E142Q之E142處之突變;選自V261A及V261I之V261處之突變;選自L264A、L264H及L264M之L264處之突變;選自E391Y、E391W、E391F、E391H、E391M、E391K及E391R之E391處之突變;選自D521R及D521K之D521處之突變;選自E523Y及E523K之E523處之突變;及選自S319L、L437Y、E482K、D492H、K500E、E519R、T568S及M569V之突變。
應瞭解,出於本發明之目的,本文所描述之屎腸球菌聚合酶修飾可根據不同功能增強或不同結構域分類。有利地,本發明之經修飾屎腸球菌聚合酶包含複數個選自本文所描述之不同功能及/或結構分類的修飾。此例示為根據本文所描述之實施例工程改造的經修飾屎腸球菌聚合酶變異體,其列於表2中。在一些實施例中,經修飾屎腸球菌聚合酶包含與表2中提供之SEQ ID No: 34-305中之任一者至少25-50%、50-60%、60-70%、70-80%、80-90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%一致的胺基酸序列。在一些實施例中,經修飾屎腸球菌聚合酶包含SEQ ID No: 34-305中之任一者之胺基酸序列。在一些實施例中,經修飾屎腸球菌聚合酶由與表2中所提供之SEQ ID No: 34-305中之任一者至少25-50%、50-60%、60-70%、70-80%、80-90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%一致的胺基酸序列組成。在一些實施例中,經修飾屎腸球菌聚合酶由SEQ ID NO: 34-305中之任一者之胺基酸序列組成。在一些實施例中,經修飾屎腸球菌聚合酶包含與SEQ ID NO: 88、SEQ ID NO: 157或SEQ ID NO: 180至少25-50%、50-60%、60-70%、70-80%、80-90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%一致之胺基酸序列。在一些實施例中,經修飾屎腸球菌聚合酶包含SEQ ID NO: 88、SEQ ID NO: 157或SEQ ID NO: 180之胺基酸序列。在一些實施例中,經修飾屎腸球菌聚合酶由SEQ ID NO: 88、SEQ ID NO: 157或SEQ ID NO: 180之胺基酸序列組成。
在一些實施例中,經修飾聚合酶中之唯一修飾為本發明中所提供之修飾(例如,屎腸球菌聚合酶中之胺基酸取代)中之一或多者,且聚合酶之序列另外與野生型聚合酶(例如,SEQ ID NO: 2-5)或與表2或表7中描述之序列一致。
(ii)經修飾 Φ29 聚合酶 在一些實施例中,經修飾聚合酶係經修飾Φ29聚合酶(亦即包含Φ29聚合酶大多數序列,諸如SEQ ID NO: 1)。
在一些實施例中,經修飾Φ29聚合酶包含一或多個對應於以下之位置(例如,2個或更多個、5個或更多個、10個或更多個、15個或更多個、20個或更多個,例如1、2、3、4、5、6、7、8、9、10、11、12、13、14、15、16、17、18、19、20、21、22、23、24、25、26、27、28、29、30、31、32、33、34、35、36、37、38、39、40、41、42、43或44個位置,以其任何組合)處之胺基酸修飾(亦即突變):參考Φ29聚合酶中之M8、V51、N62、I71、L107、K131、K135、L142、G135、L142、Y148、G197、Y224、Y226、E239、V250、N251、L253、Y281、I288、T301、R306、R308、D325、D341、K354、T368、E375、K379、Q380、A437、A444、P447、E466、D476、K478、A484、E508、D510、K512、E515、K539、D570或T571。
此類修飾可包含缺失(例如在對應於以下之位置處之胺基酸缺失:參考Φ29聚合酶中之M8、V51、N62、I71、L107、K131、K135、L142、G135、L142、Y148、G197、Y224、Y226、E239、V250、N251、L253、Y281、I288、T301、R306、R308、D325、D341、K354、T368、E375、K379、Q380、A437、A444、P447、E466、D476、K478、A484、E508、D510、K512、E515、K539、D570或T571 (或其任何組合))。
替代地或另外,此類修飾可包含添加(例如在對應於以下之位置處添加同源胺基酸:參考Φ29聚合酶中之M8、V51、N62、I71、L107、K131、K135、L142、G135、L142、Y148、G197、Y224、Y226、E239、V250、N251、L253、Y281、I288、T301、R306、R308、D325、D341、K354、T368、E375、K379、Q380、A437、A444、P447、E466、D476、K478、A484、E508、D510、K512、E515、K539、D570或T571 (或其任何組合))。
替代地或另外,此類修飾可包含取代。舉例而言,修飾可包含一或多個對應於以下之位置(例如在1-44個位置,或在例如2個或更多個、5個或更多個、10個或更多個、15個或更多個、20個或更多個之間的任何整數(例如所有),以及其任何組合)處之取代:Φ29聚合酶中之M8、V51、N62、I71、L107、K131、K135、L142、G135、L142、Y148、G197、Y224、Y226、E239、V250、N251、L253、Y281、I288、T301、R306、R308、D325、D341、K354、T368、E375、K379、Q380、A437、A444、P447、E466、D476、K478、A484、E508、D510、K512、E515、K539、D570及T571。在一些實施例中,取代係選自由以下組成之群:M8R、V51A、N62D、I71V、L107I、K131E、K135Q、L142K、Y148I、G197D、Y224K、Y226F、E239G、V250A、V250I、N251R、L253A、L253H、Y281H、I288L、T301C、R306Q、R308L、D325E、D341E、K354R、T368F、E375K、E375Y、K379R、Q380R、A437G、A444T、E466K、D476H、P477D、K478D、A484C、A484Q、A484N、A484E、A484D、A484K、A484R、A484H、A484Y及A484X (其中X表示非天然胺基酸,如本文所描述)、E508R、D510K、D510R、K512Y、E515Q、K539E、D570S及T571V (對應於參考Φ29聚合酶中之位置)。
舉例而言,在一些實施例中,其中經修飾聚合酶包含Φ29聚合酶大多數序列,經修飾聚合酶包含一或多個在如前文中列出之位置處的突變。在一些實施例中,其中經修飾聚合酶不包含Φ29聚合酶大多數序列,經修飾聚合酶包含一或多個對應於上述所列出之位置的胺基酸,例如,如藉由同源性比對或此項技術中已知之其他方法測定。
在一些實施例中,經修飾聚合酶包含在一或多個對應於Φ29聚合酶中之Y148、Y226、V250、N251、T368、E375、K379、Q380、A437、P477、K478及A484之位置處的突變。在一些實施例中,本發明之經修飾聚合酶為包含在Y148、Y226、V250、N251、T368、E375、K379、Q380、A437、P477、K478及A484中之一或多者處之突變的經修飾Φ29聚合酶。在一些實施例中,經修飾聚合酶包含Y148I、Y226F、V250A、N251R、T368F、E375K、K379R、Q380R、A437G、P477D、K478D及A484C中之一或多者。在一些實施例中,經修飾聚合酶包含Y148I、Y226F、V250A、N251R、T368F、E375K、K379R、Q380R、A437G、P477D、K478D及A484S中之一或多者。在一些實施例中,經修飾聚合酶包含Y148I、Y226F、V250A、N251R、T368F、E375K、K379R、Q380R、A437G、P477D、K478D及A484T中之一或多者。在一些實施例中,經修飾聚合酶包含Y148I、Y226F、V250A、N251R、T368F、E375K、K379R、Q380R、A437G、P477D、K478D及A484Q中之一或多者。在一些實施例中,經修飾聚合酶包含Y148I、Y226F、V250A、N251R、T368F、E375K、K379R、Q380R、A437G、P477D、K478D及A484N中之一或多者。在一些實施例中,經修飾聚合酶包含Y148I、Y226F、V250A、N251R、T368F、E375K、K379R、Q380R、A437G、P477D、K478D及A484E中之一或多者。在一些實施例中,經修飾聚合酶包含Y148I、Y226F、V250A、N251R、T368F、E375K、K379R、Q380R、A437G、P477D、K478D及A484D中之一或多者。在一些實施例中,經修飾聚合酶包含Y148I、Y226F、V250A、N251R、T368F、E375K、K379R、Q380R、A437G、P477D、K478D及A484K中之一或多者。在一些實施例中,經修飾聚合酶包含Y148I、Y226F、V250A、N251R、T368F、E375K、K379R、Q380R、A437G、P477D、K478D及A484R中之一或多者。在一些實施例中,經修飾聚合酶包含Y148I、Y226F、V250A、N251R、T368F、E375K、K379R、Q380R、A437G、P477D、K478D及A484H中之一或多者。在一些實施例中,經修飾聚合酶包含Y148I、Y226F、V250A、N251R、T368F、E375K、K379R、Q380R、A437G、P477D、K478D及A484Y中之一或多者。在一些實施例中,經修飾聚合酶包含Y148I、Y226F、V250A、N251R、T368F、E375K、K379R、Q380R、A437G、P477D、K478D及A484X中之一或多者,其中X表示非天然胺基酸,如本文中所描述。如本文所用,一或多個可以係2個或更多個、4個或更多個、6個或更多個、8個或更多個、10個或更多個、12個或更多個,例如,所有之所列出之胺基酸取代。
在一些實施例中,經修飾聚合酶包含在一或多個對應於Φ29聚合酶中之M8、V51、N62、I71、L107、K131、K135、L142、G197、Y224、E239、V250、L253、Y281、I288、T301、R306、R308、D325、D341、K354、T368、E375、A437、A444、E466、D476、A484、E508、D510、K512、E515、K539、D570及T571之位置(例如在1至35個或其間任何整數個位置,例如2個或更多個、5個或更多個、10個或更多個、15個或更多個、20個或更多個,例如所有)處的突變。在一些實施例中,經修飾聚合酶為包含在Φ29聚合酶中之M8、V51、N62、I71、L107、K131、K135、L142、G197、Y224、E239、V250、L253、Y281、I288、T301、R306、R308、D325、D341、K354、T368、E375、A437、A444、E466、D476、A484、E508、D510、K512、E515、K539、D570及T571中之一或多者處的突變的經修飾Φ29聚合酶。在一些實施例中,經修飾聚合酶包含一或多個(例如在1至35個或其間任何整數個,例如2個或更多個、5個或更多個、10個或更多個、15個或更多個、20個或更多個,例如所有)以下突變:M8R、V51A、N62D、I71V、L107I、K131E、K135Q、L142K、G197D、Y224K、E239G、V250A、V250I、L253A、L253H、Y281H、I288L、T301C、R306Q、R308L、D325E、D341E、K354R、T368F、E375Y、A437G、A444T、E466K、D476H、A484E、E508R、D510K、D510R、K512Y、E515Q、K539E、D570S及T571V。
在一些實施例中,經修飾聚合酶包含在一或多個對應於Φ29聚合酶中之K135、L142、Y224、E239、V250、L253、E375、A437、E466、D476、A484、E508、D510、K512、E515、K539、D570及T571之位置(例如在1-18個或其間任何整數個位置,例如2個或更多個、5個或更多個、10個或更多個、15個或更多個,例如所有)處的突變。在一些實施例中,本發明之經修飾聚合酶為包含在K135、L142、Y224、E239、V250、L253、E375、A437、E466、D476、A484、E508、D510、K512、E515、K539、D570及T571中之一或多者處之突變的經修飾Φ29聚合酶。在一些實施例中,經修飾聚合酶包含K135Q、L142K、Y224K、E239G、V250I、L253A、E375Y、A437G、E466K、D476H、A484E、E508R、D510R、K512Y、E515Q、K539E、D570S及T571V中之一或多者(例如1-18個或其間任何整數個,例如2個或更多個、5個或更多個、10個或更多個、15個或更多個,例如所有)。
在一些實施例中,經修飾聚合酶包含在一或多個(例如1、2或3個)對應於Φ29聚合酶之G197、I71及L107之位置處的突變。在一些實施例中,本發明之經修飾聚合酶為包含在G197、I71及L107中之一或多者(例如1、2或3者)處的突變的經修飾Φ29聚合酶。在一些實施例中,經修飾聚合酶包含G197D、I71V及L107I中之一或多者(例如1、2或3者)。
C. 域、子域及區段修飾
如上文所述,修飾可包含一或多個胺基酸(其可為或可不為連續的)之添加、取代或缺失,諸如:(i)聚合酶域、子域或區段內之胺基酸之添加、取代或缺失;或(i)聚合酶域、子域或區段之添加、取代或缺失。
圖2,圖9B及圖15提供例示性聚合酶域及子域。舉例而言,圖2描繪Φ29聚合酶200 之圖解說明。摺疊三維結構包含對應於覆蓋圖202 之相異的域及子域:N端外切核酸酶域(1)及含有掌型子域(2)、末端蛋白質區域1 (terminal protein region,TPR1)子域(3)、手指型子域(4)、TPR2子域(5)及拇指型子域(6)之C端聚合酶域。此等域及子域映射至根據多肽結構204 之多肽股區,其以N端至C端方式定向。如所示,N端外切核酸酶域(1)之跨度為野生型Φ29聚合酶之殘基1-189且C端聚合酶域之跨度為該聚合酶之殘基190-575。在C端聚合酶域中,掌型子域(2)之跨度為野生型Φ29聚合酶之殘基190-260及427-530,TPR1子域(3)之跨度為該聚合酶之殘基261-358,手指型子域(4)之跨度為該聚合酶之殘基359-394,TPR2子域(5)之跨度為該聚合酶之殘基395-426,且拇指型子域(6)之跨度為該聚合酶之殘基531-575。
如本文所用,聚合酶「區段」係指聚合酶之部分(例如,至少2個或更多連續胺基酸)。在一些實施例中,區段包含至少2個、至少3個、至少4個、至少5個、至少10個、至少15個、至少20個、至少25個、至少30個、至少35個、至少40個、至少45個、至少50個、至少55個、至少60個、至少65個、至少70個、至少75個、至少80個、至少85個、至少90個、至少95個、至少100個、至少110個、至少120個、至少130個、至少140個、至少150個、至少160個、至少170個、至少180個、至少190個、至少200個、至少210個、至少220個、至少230個、至少240個、至少250個、至少275或至少300個連續聚合酶胺基酸。在一些實施例中,區段包含2、3、4、5、6、7、8、9、10、11、12、13、14、15、16、17、18、9、20、21、22、23、44、25、26、27、28、29、30、31、32、33、34、35、36、37、38、9、40、41、42、43、44、45、46、47、48、49、50、51、52、53、54、55、56、57、58、59、60、61、62、63、64、65、66、67、68、69、70、71、72、73、74、75、76、77、78、79、80、81、82、83、84、85、86、87、88、89、90、91、92、93、94、95、96、97、98、99、100、105、110、115、120、125、130、140或150個連續聚合酶胺基酸。在一些實施例中,區段包含聚合酶之域或子域。
(i) 聚合酶域、子域或區段內之修飾 在一些實施例中,本申請案之重組聚合酶包含一或多個在聚合酶之一或多個域、子域或區段(視情況包括側接胺基酸)中之胺基酸突變。在一些實施例中,重組聚合酶包含一或多個在外切核酸酶區域、掌型區域、TPR1區域、手指型區域、TPR2區域及拇指型區域中之一或多者中的胺基酸突變。
在一些實施例中,重組聚合酶包含在外切核酸酶區域(例如外切核酸酶區域之外切核酸酶環)中之一或多個位置處的突變。在一些實施例中,具有屎腸球菌聚合酶大多數序列之重組聚合酶包含在外切核酸酶區域中之一或多個位置處之突變。例如,在一些實施例中,本發明之重組聚合酶為包含在對應於以下之一或多者(例如,2、3、4、5、6、7、8、9、10、11、12、13、14、15、16、17、18、19、20、21、22、23、24、25、26、27、28、29、30、31、32、33、34、35或36者,以任何組合形式)處之突變的經修飾屎腸球菌聚合酶:屎腸球菌聚合酶之外切核酸酶區域中之K4、T13、S22、V25、C26、D27、N33、I34、F36、S42、D54、N59、E60、E65、E85、M95、N106、T110、T114、K119、Q122、Y133、P136、E139、E142、N145、P147、I148、E152、I153、P160、D167、D171、N175、F188及D189。在一些實施例中,重組聚合酶包含在一或多個對應於以下之位置(例如,2、3、4、5、6、7、8、9、10、11、12、13、14、15、16、17、18、19、20、21、22、23、24、25、26、27、28、29、30、31、32、33、34、35或36個位置,以任何組合形式)處之突變:屎腸球菌聚合酶中之K4、T13、S22、V25、C26、D27、N33、I34、F36、S42、D54、N59、E60、E65、E85、M95、N106、T110、T114、K119、Q122、Y133、P136、E139、E142、N145、P147、I148、E152、I153、P160、D167、D171、N175、F188及D189。相應地,在一些實施例中,在重組聚合酶不包含屎腸球菌聚合酶大多數序列之情況下,重組聚合酶包含一或多個對應於上述列出之位置的胺基酸,例如,如藉由同源性比對或此項技術中已知之其他方法所測定。在一些實施例中,重組聚合酶包含以下中之一或多者:K4R、T13N、S22A、V25L、C26W、D27E、N33T、I34V、F36V、S42T、D54Y、N59D、E60L、E60V、E65S、E85P、M95T、M95K、N106G、T110I、T114S、K119Q、Q122V、Y133L、P136T、E139K、E139Q、E139R、E139H、E142K、E142Q、E142R、E142H、N145K、N145H、N145R、P147Q、P147T、I148K、I148H、I148R、E152D、I153V、P160A、D167P、D167K、D167H、D167R、D171K、D171H、D171R、N175T、N175Y、F188C、D189K、D189H及D189R。
在一些實施例中,本發明之經修飾屎腸球菌聚合酶包含消除或降低外切核酸酶活性之修飾。舉例而言,在一些實施例中,經修飾屎腸球菌聚合酶包含N59處之突變,其消除或降低外切核酸酶活性。在一些實施例中,經修飾屎腸球菌聚合酶包含N59D。在一些實施例中,經修飾屎腸球菌聚合酶不包含N59處之突變(例如經修飾屎腸球菌聚合酶包含N59)。應瞭解,視所需功能性而定,經修飾屎腸球菌聚合酶中N59處之突變可引入或恢復回野生型。相應地,在一些實施例中,經修飾屎腸球菌聚合酶包含選自表2之序列,其經進一步修飾以在N59處引入突變(例如經進一步修飾以包含N59D)。在一些實施例中,經修飾屎腸球菌聚合酶包含選自表2之序列,其經進一步修飾以使N59處之突變恢復回野生型(例如,經進一步修飾以包含D59N)。
在一些實施例中,具有Φ29聚合酶大多數序列之經修飾聚合酶包含在外切核酸酶區域中之一或多個位置處的突變。舉例而言,在一些實施例中,本發明之經修飾聚合酶為包含在對應於以下之一或多者(例如,2、3、4、5、6、7、8、9、10或11者,以任何組合形式)處之突變的經修飾Φ29聚合酶:Φ29聚合酶之外切核酸酶區域中之E75、R76、S82、A83、D84、G85、L86、P87、N88、Y90及N91。在一些實施例中,經修飾聚合酶包含一或多個在對應於Φ29聚合酶中之E75、R76、S82、A83、D84、G85、L86、P87、N88、Y90及N91之位置處的胺基酸突變。相應地,在一些實施例中,其中經修飾聚合酶不包含Φ29聚合酶大多數序列,經修飾聚合酶包含一或多個對應於上述所列出之位置的胺基酸,例如,如藉由同源性比對或此項技術中已知之其他方法所測定。在一些實施例中,經修飾聚合酶包含E75F、R76K、S82C、A83K、D84E、G85A、L86K、P87E、N88R、Y90F及N91S中之一或多者。相應地,在一些實施例中,包含外切核酸酶域或其部分之區段用於交換來自不同聚合酶之對應的外切核酸酶域。舉例而言,在一些實施例中,包含一種聚合酶之外切核酸酶域之環及側接胺基酸的區段經來自另一聚合酶之對應的區段置換。舉例而言,在一些實施例中,Φ29 E75-N91區段用來自屎腸球菌之對應F72-S89區段置換。在一些實施例中,交換包含外切核酸酶環的區段可以減小聚合酶之脈衝間距離。
在一些實施例中,經修飾聚合酶包含在TPR1區域中之一或多個位置處的突變。舉例而言,在一些實施例中,經修飾聚合酶包含在一或多個對應於以下之位置(例如1、2、3、4、5、6或7個,以任何組合形式)處的突變:屎腸球菌聚合酶中之P273、P275、R308、V315、Q317、S319、L320、I322、Q323、D337、E338、D341、T345、F352、F353、T364及D374。在一些實施例中,本發明之經修飾聚合酶為包含在R308、S319、L320、E323、D337、E338及D341中之一或多者(例如,1、2、3、4、5、6或7者,以任何組合形式)處之突變的經修飾屎腸球菌聚合酶。在一些實施例中,將R308、S319、L320、E323、D337、E338及D341中之一或多者(例如1、2、3、4、5、6或7者)處之胺基酸變為其他聚合酶(例如Φ29、M2Y、銅綠蠅、芽孢桿菌菌株,例如GA-1)中之對應位置處之胺基酸。在一些實施例中,經修飾聚合酶包含R308G、S319L、L320M、E323V、D337G、E338K及D341T中之一或多者(例如,1、2、3、4、5、6或7者,以任何組合形式)。
在一些實施例中,經修飾聚合酶包含在一或多個(例如1、2、3、4、5或6個,以任何組合形式)對應於以下之位置處的突變:Φ29聚合酶中之Y281、I288、T301、D325、D341及K354。在一些實施例中,本發明之經修飾聚合酶為包含在Y281、I288、T301、D325、D341及K354中之一或多者(例如1、2、3、4、5或6者,以任何組合形式)處之突變的經修飾Φ29聚合酶。在一些實施例中,Y281、I288、T301、D325、D341及K354中之一或多者(例如1、2、3、4、5或6個,以任何組合形式)處之胺基酸變為其他聚合酶(例如M2Y、銅綠蠅、芽孢桿菌菌株,例如GA-1)中之對應位置處之胺基酸。在一些實施例中,經修飾聚合酶包含Y281H、I288L、T301C、D325E、D341E及K354R中之一或多者(例如,1、2、3、4、5或6者,以任何組合形式)。在一些實施例中,在一或多個(例如1、2、3、4、5或6個)對應於Φ29聚合酶中之Y281、I288、T301、D325、D341及K354之位置處的突變增加併入率(例如在單分子定序反應中)。
在一些實施例中,經修飾聚合酶包含在掌型區域中之一或多個位置處之突變。例如,在一些實施例中,經修飾聚合酶包含一或多個(例如,1、2、3、4、5、6、7、8、9、10、11、12、13、14、15、16、17、18、19、20、21、22、23、24、25、26、27、28、29、30、31、32、33、34、35、36、37、38或39個,以任何組合形式)對應於以下之位置處的突變:屎腸球菌聚合酶中之Q206、T211、S216、R217、D232、A236、V247、I253、V261、L264、S267、V443、L445、A446、S447、V449、T450、W452、G453、Y455、F465、N467、T479、E482、A484、E485、A486、L490、D492、S493、K495、K500、S503、Q506、Q513、E519、D521、E523及V526。在一些實施例中,本發明之經修飾聚合酶為包含在以下之一或多者(例如,1、2、3、4、5、6、7、8、9、10、11、12、13、14、15、16、17、18、19、20、21、22、23、24、25、26、27、28、29、30、31、32、33、34、35、36、37、38或39者,以任何組合形式)處之突變的經修飾屎腸球菌聚合酶:T211、D232、V261、L264、T479、E482、D492、S493、K500、Q513、E519、D521及E523。在一些實施例中,在T211、D232、V261、L264、T479、E482、D492、S493、K500、Q513、E519、D521及E523中之一或多者(例如,1、2、3、4、5、6、7、8、9、10、11、12、13、14、15、16、17、18、19、20、21、22、23、24、25、26、27、28、29、30、31、32、33、34、35、36、37、38或39,以任何組合形式)處之胺基酸變為其他聚合酶(例如,Φ29、M2Y、銅綠蠅、芽孢桿菌菌株,例如GA-1)中對應位置處之胺基酸。在一些實施例中,修飾係選自由以下組成之群:Q206R、Q206K、Q206H、T211A、S216G、S216R、R217G、D232K、A236G、V247D、I253H、I253A、V261A、V261I、V261L、L264H、L264A、L264M、V443T、L445M、A446G、S447V、V449I、T450A、W452Y、G453A、Y455W、F465Y、N467R、N467K、N467H、N467S、N467T、T479V、E482K、E482H、E482R、A484E、E485D、A486E、L490M、D492H、D492K、D492R、D492A、H492S、S493P、K495R、K500E、S503A、S503T、Q506K、Q513D、D521K、D521R、D521H、E523R、E523V、E523Y、E523F、E523H、E523W及V526L。
在一些實施例中,經修飾聚合酶包含在一或多個(例如1、2、3、4或5個,以任何組合形式)對應於Φ29聚合酶中之M429、G430、V431、I433及A444之位置處的突變。在一些實施例中,本發明之經修飾聚合酶為包含在M429、G430、V431、I433及A444之一或多個位置(例如1、2、3、4或5個,以任何組合形式)處之突變的經修飾Φ29聚合酶。在一些實施例中,M429、G430、V431、I433及A444中之一或多者(例如1、2、3、4或5者,以任何組合形式)處之胺基酸變為其他聚合酶(例如M2Y、銅綠蠅、芽孢桿菌菌株,例如GA-1)中之對應位置處之胺基酸。在一些實施例中,經修飾聚合酶包含M429L、G430A、V431S、I433V及A444T中之一或多者(例如,1、2、3、4或5者,以任何組合形式)。在一些實施例中,在一或多個(例如1、2、3、4或5個,以任何組合形式)對應於Φ29聚合酶中之M429、G430、V431、I433及A444之位置處的突變增加精確度(例如在單分子定序反應中)。
在一些實施例中,經修飾聚合酶包含在手指型區域中之一或多個位置處之突變。舉例而言,在一些實施例中,經修飾聚合酶包含在一或多個(例如1、2、3、4、5、6或7個,以任何組合形式)對應於屎腸球菌聚合酶中之I384、E385、N388、E391、A396、N397及G400之位置處的突變。在一些實施例中,本發明之經修飾聚合酶為包含在一或多個(例如1、2、3、4、5、6或7個,以任何組合形式)對應於屎腸球菌聚合酶中之I384、E385、N388、E391、A396、N397及G400之位置處之突變的經修飾屎腸球菌聚合酶。在一些實施例中,突變係選自由以下組成之群:I384T、I384F、I384S、E385Y、E385K、E385R、E385N、E385Q、E385L、E385A、N388T、E391Y、E391W、E391F、E391H、E391M、E391K、E391R、A396Q、N397L及G400L。在一些實施例中,一或多個(例如1、2、3、4、5、6或7個,以任何組合形式)對應於I384、E385、N388、E391、A396、N397及G400之位置處之胺基酸變為其他聚合酶(例如Φ29、M2Y、銅綠蠅、芽孢桿菌菌株,例如GA-1)中之對應位置處之胺基酸。
在一些實施例中,經修飾聚合酶包含在TPR2區域中之一或多個位置處之突變。舉例而言,在一些實施例中,經修飾聚合酶包含在一或多個(例如1、2、3、4或5個,以任何組合形式)對應於屎腸球菌聚合酶中之D414、D425、R429、E436及L437之位置處的突變。在一些實施例中,本發明之經修飾聚合酶為包含在D414、D425、R429、E436及L437中之一或多者(例如1、2、3、4或5者,以任何組合形式)處之突變的經修飾屎腸球菌聚合酶。在一些實施例中,突變係選自由以下組成之群:D414V、D425N、R429G、E436R、E436G、L437Y及L437E。在一些實施例中,對應於D414、D425、R429、E436或L437之位置處的胺基酸變為其他聚合酶中之對應位置處的胺基酸(例如Φ29、M2Y、銅綠蠅、芽孢桿菌菌株,例如GA-1)。
在一些實施例中,經修飾聚合酶包含在拇指型區域中之一或多個位置處之突變。舉例而言,在一些實施例中,經修飾聚合酶包含在一或多個對應於以下之位置(例如,1、2、3、4、5、6、7、8、9、10、11、12或13個,以任何組合形式)處之突變:屎腸球菌聚合酶中之D533、R534、E537、G547、E545、L555、P556、R558、T559、V564、T568、M569及T571。在一些實施例中,本發明之經修飾聚合酶為包含在以下之一或多者(例如,1、2、3、4、5、6、7、8、9、10、11、12或13者,以任何組合形式)處之突變的經修飾屎腸球菌聚合酶:D533、R534、E537、G547、E545、L555、P556、R558、T559、V564、T568、M569及T571。在一些實施例中,突變係選自由以下組成之群:D533A、D533Q、D533T、D533R、D533S、R534K、E537K、E537H、E537R、E545K、E545H、E545R、G547S、L555K、L555R、P556A、R558H、T559V、V564L、T568D、T568S、M569K、M569T、M569V及T571S。在一些實施例中,一或多個(例如,1、2、3、4、5、6、7、8、9、10、11、12或13個,以任何組合形式)對應於D533、R534、E537、G547、E545、L555、P556、R558、T559、V564、T568、M569及T571之位置處之胺基酸變為其他聚合酶(例如,Φ29、M2Y、銅綠蠅、芽孢桿菌菌株,例如GA-1)中之對應位置處之胺基酸。
在一些實施例中,經修飾聚合酶包含在掌型區域中之一或多個位置及外切核酸酶區域中之一或多個位置處的突變。舉例而言,在一些實施例中,經修飾聚合酶包含在一或多個(例如1、2或3個)對應於Φ29聚合酶之G197、M8及V51之位置處的突變。在一些實施例中,本發明之經修飾聚合酶為包含在G197、M8及V51中之一或多者(例如1、2或3者)處之突變的經修飾Φ29聚合酶。在一些實施例中,經修飾聚合酶包含G197D、M8R及V51A中之一或多者(例如1、2或3者)。在一些實施例中,在一或多個(例如1、2或3個)對應於Φ29聚合酶中之G197、M8及V51之位置處的突變可以提高生產率、熱穩定性及/或提高負載效率(例如,負載至陣列之樣品槽)。
在一些實施例中,經修飾聚合酶包含在掌型區域中之一或多個位置及拇指型區域中之一或多個位置處的突變。舉例而言,在一些實施例中,經修飾聚合酶包含在一或多個(例如1、2、3、4或5個)對應於Φ29聚合酶中之E466、D476、K539、D570及T571之位置處的突變。在一些實施例中,本發明之經修飾聚合酶係包含在E466、D476、K539、D570及T571中之一或多者(例如1、2、3、4或5者)處之突變的經修飾Φ29聚合酶。在一些實施例中,經修飾聚合酶包含E466K、D476H、K539E、D570S及T571V中之一或多者(例如1、2、3、4或5者)。
在一些實施例中,經修飾聚合酶包含一或多個(例如1、2、3、4、5、6或7個)在對應於M2Y聚合酶中之N59、Y145、V247、L250、E372、A481及K509之位置處的胺基酸突變。舉例而言,在一些實施例中,其中經修飾聚合酶包含M2Y聚合酶大多數序列,經修飾聚合酶包含一或多個在如前文中列出之位置處的突變。在一些實施例中,其中經修飾聚合酶不包含M2Y聚合酶大多數序列,經修飾聚合酶包含一或多個對應於上述列出之位置的胺基酸突變,例如,如藉由同源性比對或此項技術中已知之其他方法所測定。
在一些實施例中,經修飾聚合酶包含野生型聚合酶之一或多個區段(例如域或其部分,視情況包括側接胺基酸) (例如如表1中所述,例如SEQ ID NO: 1、SEQ ID NO: 2-5或SEQ ID NO: 23-33)。在一些實施例中,屎腸球菌聚合酶之一或多個區段(例如域或其部分,視情況包括側接胺基酸) (例如SEQ ID NO: 2-5中任一者之一或多個區段)可經取代用於SEQ ID NO: 1及6-33中任一者之一或多個區段。在一些實施例中,屎腸球菌聚合酶之一或多個區段(例如域或其部分,視情況包括側接胺基酸) (例如SEQ ID NO: 2-5中任一者之一或多個區段)可經取代用於SEQ ID NO: 23-33中任一者之一或多個區段。在一些實施例中,一或多個屎腸球菌聚合酶之區段(例如域或其部分,視情況包括側接胺基酸)可經取代用於一或多個Φ29聚合酶之區段。在一些實施例中,一或多個屎腸球菌聚合酶之區段(例如域或其部分,視情況包括側接胺基酸)可經取代用於一或多個M2Y聚合酶之區段。在一些實施例中,一或多個屎腸球菌聚合酶之區段(例如域或其部分,視情況包括側接胺基酸)可經取代用於一或多個Φ29聚合酶之區段及/或M2Y聚合酶之區段。在一些實施例中,屎腸球菌聚合酶之一或多個區段(例如域或其部分,視情況包括側接胺基酸) (例如SEQ ID NO: 2-5中之任一者之域或其修飾形式,例如其含有一或多個胺基酸取代)可經取代用於本文所描述之變異體聚合酶(例如表3中所列之變異體聚合酶,或表3中所說明的或表4-6中所描述的含有一或多個胺基酸取代或其他域取代之變異體聚合酶)之一或多個區段。
(ii) 聚合酶域、子域或區段 - 嵌合聚合酶之修飾 圖2描繪Φ29聚合酶200 之圖解說明。摺疊三維結構包含對應於覆蓋圖202 之相異的域及子域:N端外切核酸酶域(1)及含有掌型子域(2)、末端蛋白質區域1 (TPR1)子域(3)、手指型子域(4)、TPR2子域(5)及拇指型子域(6)之C端聚合酶域。此等域及子域映射至根據多肽結構204 之多肽股區,其以N端至C端方式定向。如所示,N端外切核酸酶域(1)之跨度為野生型Φ29聚合酶之殘基1-189且C端聚合酶域之跨度為該聚合酶之殘基190-575。在C端聚合酶域中,掌型子域(2)之跨度為野生型Φ29聚合酶之殘基190-260及427-530,TPR1子域(3)之跨度為該聚合酶之殘基261-358,手指型子域(4)之跨度為該聚合酶之殘基359-394,TPR2子域(5)之跨度為該聚合酶之殘基395-426,且拇指型子域(6)之跨度為該聚合酶之殘基531-575。此申請案中所描述之不同聚合酶之等效區段(例如域或其部分,視情況包括側接胺基酸)可以經取代用於彼此以產生嵌合聚合酶。舉例而言,來自一種聚合酶(例如具有表1中所示之野生型序列或具有表2-3中例示或表4-6中所描述之一或多個突變)之外切核酸酶域、掌型子域、TPR1子域、一或多個手指型子域、TPR2子域及/或拇指型子域中之一或多者可以經取代用於另一聚合酶中之對應的域(例如具有表1中所示之野生型序列或具有表2-3中例示或表4-6中所描述之一或多個突變)。在一些實施例中,包含此等域,視情況包括一或多個側接胺基酸中之一或多者之部分的區段可以經取代。
在一些實施例中,聚合酶之修飾包含添加區段、子域或域。舉例而言,在一些實施例中,修飾包含聚合酶之區段、子域或域之複製。在一些實施例中,修飾包含添加參考聚合酶之區段、子域或域(由此產生如本文所描述之「嵌合聚合酶」)。在一些實施例中,聚合酶之修飾包含添加非天然化學實體。舉例而言,在一些實施例中,聚合酶之修飾包含在聚合酶之N端添加一或多個組胺酸殘基。在一些實施例中,聚合酶之修飾包含添加雙生物素標籤。
在一些實施例中,聚合酶之修飾包含區段、子域或域之缺失。
在一些實施例中,聚合酶之修飾包含用參考聚合酶之對應域取代區段、子域或域(由此產生如本文所述之「嵌合聚合酶」,參見例如圖6)。舉例而言,來自一個聚合酶(例如具有表1中所示之野生型序列或具有本文中例示之一或多種突變)之外切核酸酶域、掌型子域、TPR1子域、一或多個手指型子域、TPR2子域及/或拇指型子域中之一或多者可經取代用於另一聚合酶(例如具有表1中所示之野生型序列或具有本文中例示之一或多種突變)中之對應域。在一些實施例中,包含此等域,視情況包括一或多個側接胺基酸中之一或多者之部分的區段可以經取代。
舉例而言,在一些實施例中,經修飾聚合酶包含TPR1區域取代。舉例而言,在一些實施例中,經修飾聚合酶包含來自屎腸球菌之TPR1區域(例如SEQ ID NO: 5中之V271-M375)替代對應於Φ29聚合酶(SEQ ID NO: 1)中之S260-L359之TPR1區域。
在一些實施例中,本申請案之經修飾聚合酶包含一或多個在外切核酸酶區域中之取代。舉例而言,在一些實施例中,經修飾聚合酶包含來自M2Y之外切核酸酶區域之部分(例如SEQ ID NO: 6中之M1-I51)替代對應於Φ29聚合酶(SEQ ID NO: 1)中之M1-V54之胺基酸。在一些實施例中,經修飾聚合酶包含來自屎腸球菌之外切核酸酶區域之部分(例如SEQ ID NO: 2中之F72-S89)替代對應於Φ29聚合酶(SEQ ID NO: 1)中之E75-N91之胺基酸。在一些實施例中,經修飾聚合酶包含來自M2Y之外切核酸酶區域之部分及來自屎腸球菌之外切核酸酶區域之部分分別替代對應於Φ29聚合酶中之M1-V54及E75-N91之胺基酸。
在一些實施例中,本申請案之經修飾聚合酶包含經修飾掌型區域。舉例而言,在一些實施例中,經修飾聚合酶包含來自屎腸球菌之掌型區域之部分(例如SEQ ID NO: 2中之L445-V449)替代對應於Φ29聚合酶(SEQ ID NO: 1)中之M429-I433之胺基酸。在一些實施例中,經修飾聚合酶包含在對應於Φ29聚合酶中之A444位置處之丙胺酸至胸腺嘧啶突變(例如A444T)。在一些實施例中,經修飾聚合酶包含來自屎腸球菌之掌型區域之部分及對應於Φ29聚合酶中之A444T的胺基酸突變。
在一些實施例中,經修飾聚合酶包含除了Φ29聚合酶之外的大多數聚合酶序列。在這類實施例中,大多數聚合酶序列包含一或多個可以類推至Φ29聚合酶200之區域(例如根據同源性比對、計算模擬、結構分析或任何適合方法)。如本文所用,聚合酶之「區域」係指聚合酶之相異的域或子域。舉例而言,在一些實施例中,聚合酶之區域係指N端外切核酸酶域或C端聚合酶域。在一些實施例中,聚合酶之區域係指掌型子域、TPR1子域、手指型子域、TPR2子域或拇指型子域。相應地,在一些實施例中,聚合酶之區域係指包含給定域或子域之所有胺基酸。在一些實施例中,經修飾聚合酶包含對大多數聚合酶序列之一或多個區域之修飾。在一些實施例中,經修飾聚合酶包含對大多數聚合酶序列之一或多個部分之修飾。如本文所用,聚合酶之「部分」係指聚合酶序列中之一段兩個或更多個連續殘基。在一些實施例中,聚合酶序列之部分係指單個聚合酶域或單個聚合酶子域中之兩個或更多個連續胺基酸。在一些實施例中,聚合酶序列之部分係指跨越多於一個聚合酶域及/或聚合酶子域之兩個或更多個連續胺基酸。因此,在一些實施例中,聚合酶序列之部分係聚合酶序列中之任何段之連續胺基酸。在一些實施例中,部分係指構成,例如聚合酶區域或域之部分的5-10個連續胺基酸、10-25個連續胺基酸、25-50個連續胺基酸、50-75個連續胺基酸、75-100個連續胺基酸或其他數目之連續胺基酸。
在一些實施例中,經修飾聚合酶包含一或多個如圖2中大體描繪之域及/或子域中之一或多者中之單點突變。舉例而言,圖3描繪表3之所選擇之突變變異體,該等突變變異體具有在各多肽股中之突變之位點(用箭頭大致展示)。多肽股針對以下展示:M2Y及M2Y突變變異體H016、銅綠蠅及銅綠蠅突變變異體H018、屎腸球菌及屎腸球菌突變變異體H020及芽孢桿菌噬菌體VMY22及芽孢桿菌噬菌體VMY22突變變異體H022。然而,亦可使用包含如本文中所描述之其他區段交換及/或胺基酸突變之嵌合體。
在一些實施例中,除本文中所描述之一或多個單點突變修飾之外或替代本文中所描述之一或多個單點突變修飾,大多數聚合酶序列之一段胺基酸(例如兩個或更多個連續胺基酸)經修飾。在一些實施例中,該段胺基酸係對應於不同聚合酶序列之部分之一段胺基酸。舉例而言,在一些實施例中,大多數聚合酶序列之域/子域(或其中部分)與不同聚合酶序列之對應的域/子域(或其中部分)交換。在這類實施例中,聚合酶稱為嵌合聚合酶、嵌合聚合酶變異體或嵌合體。嵌合聚合酶係根據本文中所描述之實施例經工程改造且列於表4中。
在一些實施例中,本發明之經修飾重組聚合酶係選自表4。在一些實施例中,嵌合聚合酶變異體(例如如表4中所列出)包含具有經不同聚合酶序列之對應的區域或部分取代的大多數序列之區域或部分的大多數聚合酶序列。在一些實施例中,所有包含大多數聚合酶序列中之區域(例如域及/或子域)之殘基經所有包含不同聚合酶序列中之對應的區域之殘基取代。在一些實施例中,包含大多數聚合酶序列中之區域之殘基之至少一部分經包含不同聚合酶序列中之對應的區域之殘基之至少一部分取代。
在一些實施例中,僅大多數序列中之單個子域經不同序列之對應的子域取代。舉例而言,圖4描繪選自表4之嵌合聚合酶變異體。六個所選擇之變異體作為具有如其一般在多肽中出現之以胺基端至羧基端定向之子域的多肽股展示。圖4之多肽股中之每一者包含Q001之聚合酶大多數序列(陰影線填充),具有一或多個經M2Y聚合酶(SEQ ID NO: 6,開放填充)之一或多個對應的域及/或子域或銅綠蠅(SEQ ID NO: 7,點劃填充)之一或多個對應的域及/或子域及或一或多個側接胺基酸取代的域及/或子域。
在一些實施例中,嵌合聚合酶變異體包含具有經取代自不同聚合酶序列之外切核酸酶域的大多數聚合酶序列。如圖4中所示,C017係包含經取代自M2Y聚合酶序列(例如如SEQ ID NO: 6中所述)之外切核酸酶域的嵌合聚合酶變異體。類似地,C020包含經取代自銅綠蠅聚合酶序列(例如如SEQ ID NO: 7中所述)之外切核酸酶域。在一些實施例中,在聚合酶之校讀能力不理想之情況下(例如在定序反應中),在經修飾聚合酶變異體中外切核酸酶域之修飾或置換可能很有用。然而,應瞭解,本發明之經修飾重組聚合酶涵蓋額外及替代域及/或子域取代。
在一些實施例中,嵌合聚合酶變異體包含具有經取代自不同聚合酶序列之外切核酸酶環的大多數聚合酶序列。如本文所用,在一些實施例中,「外切核酸酶環」係指形成外切核酸酶域中之環區域之一段連續胺基酸。舉例而言,圖5A描繪全透視圖500 及放大透視圖502 中之Φ29聚合酶之圖解說明。放大透視圖502 係於全透視圖500 中所示之方形區之特寫視圖,其展示Φ29聚合酶之外切核酸酶域中之環區域。所選擇之環殘基在放大透視圖502 中以桿形式展示,具有形成跨越殘基N77至N88之外切核酸酶環的該段連續胺基酸。外切核酸酶域之此區域之進化保守性分析揭示,該環及若干側接殘基之保守相對不佳。圖5B描繪Φ29聚合酶之外切核酸酶區域與選自表1之一組非限制性其他聚合酶之間的同源性比對504 。亦描繪了展示Φ29聚合酶之外切核酸酶環N77-N88與其他聚合酶中之對應的外切核酸酶環的環同源性比對506
根據同源性分析展示對應於Φ29聚合酶之外切核酸酶環N77-N88之區域中之相對較低保守性,提供了在聚合酶變異體中搜索所期望的生化特性時之變化源(例如適合用於定序反應中的)。相應地,在一些實施例中,嵌合聚合酶變異體包含具有經取代自不同聚合酶序列之外切核酸酶環的大多數聚合酶序列,其中「外切核酸酶環」與Φ29聚合酶之外切核酸酶環N77-N88同源(例如如藉由圖5B中之環同源性比對506 所示)。
如藉由圖5B中之實例比對所示,序列同源性分析可用於鑑別與Φ29聚合酶之N77-N88同源之外切核酸酶環序列。借助於實例而非限制,環同源性比對506 展示M2Y (H74-N85)、銅綠蠅(N64-G76)、屎腸球菌(N74-R86)、芽孢桿菌GA-1 (N74-K88)、芽孢桿菌VMY22 (K80-K91)、放線菌AV-1 (H93-K105)、馬鈴薯包囊線蟲(L86-K99)、伊比利亞猞猁腸(D73-R87)、候選種(N85-N98)及埃格特菌屬(V73-K88)之同源外切核酸酶環序列。相應地,在一些實施例中,經取代外切核酸酶環在與Φ29聚合酶之N77-N88同源之區域中可包括約12個與約16個之間的胺基酸。在一些實施例中,經取代外切核酸酶環在與Φ29聚合酶之N77-N88同源之區域中包含約10個胺基酸至至多20個胺基酸、約5個胺基酸至至多15個胺基酸、約5個胺基酸至至多20個胺基酸、或約5個胺基酸至25個胺基酸或更多。
在一些實施例中,本申請案之經修飾聚合酶包含一或多個包括與Φ29聚合酶之N77-N88同源之外切核酸酶環之外切核酸酶域的區域中的胺基酸突變。舉例而言,在一些實施例中,本發明之經修飾聚合酶係包含在Φ29聚合酶中之E75、R76、S82、A83、D84、G85、L86、P87、N88、Y90及N91中之一或多者處之突變的經修飾Φ29聚合酶。在一些實施例中,經修飾聚合酶包含E75F、R76K、S82C、A83K、D84E、G85A、L86K、P87E、N88R、Y90F及N91S中之一或多者。在一些實施例中,經修飾聚合酶包含一或多個在對應於Φ29聚合酶中之E75、R76、S82、A83、D84、G85、L86、P87、N88、Y90及N91之位置處的胺基酸突變。舉例而言,在一些實施例中,其中經修飾聚合酶不包含Φ29聚合酶大多數序列,經修飾聚合酶包含一或多個對應於上述列出之位置的胺基酸,例如,如藉由同源性比對或此項技術中已知之其他方法所測定。
在一些實施例中,嵌合聚合酶變異體包含具有經取代自不同聚合酶序列之TPR1子域的大多數聚合酶序列。舉例而言,C018係包含經取代自M2Y聚合酶序列之TPR1子域的嵌合聚合酶。類似地,C021包含經取代自銅綠蠅聚合酶之TPR1子域。在一些實施例中,嵌合聚合酶變異體包含具有經取代自不同聚合酶序列之掌型子域的大多數聚合酶序列。在一些實施例中,嵌合聚合酶變異體包含具有經取代自不同聚合酶序列之手指型子域的大多數聚合酶序列。在一些實施例中,嵌合聚合酶變異體包含具有經取代自不同聚合酶序列之TPR2子域的大多數聚合酶序列。在一些實施例中,嵌合聚合酶變異體包含具有經取代自不同聚合酶序列之拇指型子域的大多數聚合酶序列。如本文中所描述之經修飾重組聚合酶包括包含多於一個域及/或子域取代之嵌合聚合酶變異體。
在一些實施例中,大多數序列中之兩個區域(例如域/子域)經不同序列之兩個對應的區域(例如對應的域/子域)取代。舉例而言,如圖4中所示,C019係包含經M2Y聚合酶序列之對應的外切核酸酶域及TPR1子域取代的外切核酸酶域及TPR1子域的嵌合聚合酶。類似地,C022包含經銅綠蠅聚合酶之對應的外切核酸酶域及TPR1子域取代的外切核酸酶域及TPR1子域。在一些實施例中,涵蓋具有本文中所描述之經修飾聚合酶之額外域及/或子域取代。舉例而言,在一些實施例中,大多數序列中之多於兩個(例如三、四、五或六個)區域(例如域/子域)經不同序列之多於兩個(例如三、四、五或六個)對應的區域取代。
在一些實施例中,嵌合聚合酶變異體之大多數聚合酶序列係選自表1-4中之序列。在一些實施例中,嵌合聚合酶變異體之大多數聚合酶序列係選自SEQ ID NO: 2-5或SEQ ID NO: 23-33。在一些實施例中,大多數聚合酶序列包含一或多個經取代自選自表1-4之不同聚合酶序列之區域及/或部分。舉例而言,表5提供自表4選擇之嵌合聚合酶變異體之概述,且針對各者列舉大多數聚合酶序列以及經取代區域/部分及該取代所基於之序列之描述。
然而,可使用及/或另外修飾,例如,如本文中之表中之一或多者中所描述及所說明之其他嵌合體。
在一些實施例中,嵌合聚合酶變異體可以進一步包含一或多個定點突變。因此,在一些實施例中,可將本文中所描述之一或多個突變中之任一者(例如,包括在表2-3中之各序列中之一或多個突變中之任一者)施加至本發明中所涵蓋之任何嵌合聚合酶(例如,如上文中及表4中所列)。圖6大體描繪包含一或多個突變之嵌合聚合酶變異體。舉例而言,突變嵌合聚合酶602 包含具有經取代M2Y外切核酸酶域及該經取代域中之突變的Φ29聚合酶大多數序列。在一些實施例中,突變嵌合聚合酶包含具有經對應於兩個或更多個不同聚合酶序列之區域取代的兩個或更多個區域的大多數序列。舉例而言,突變嵌合聚合酶604 包含具有經取代屎腸球菌聚合酶TPR1子域及經取代M2Y聚合酶TPR2子域的Φ29聚合酶大多數序列,其具有在聚合酶序列中之各種位置進行之定點突變。在一些實施例中,突變嵌合聚合酶包含具有經對應於不同聚合酶之區域取代的兩個或更多個區域的大多數序列。舉例而言,突變嵌合聚合酶606 包含具有經取代屎腸球菌聚合酶TPR1、TPR2及拇指型子域的Φ29聚合酶大多數序列,其具有在聚合酶序列中之各種位置進行之定點突變。
表6提供自表4中選擇之嵌合聚合酶變異體之概述,其針對各者提供大多數聚合酶序列以及對特定變異體所作出之胺基酸突變之描述。
然而,其他胺基酸突變可以併入至一或多個本文中所描述之嵌合聚合酶中。舉例而言,一或多個胺基酸變化可在位置M8、V51、N62、I71、L107及/或K131中之一或多者處,及/或在參考Φ29聚合酶序列之位置K135、L142、G197、Y224、E239、V250、L253、Y281、I288、T301、R306、R308、D325、D341、K354、T368、E375、A437、A444、E466、D476、A484、E508、D510、K512、E515、K539、D570及T571中之一或多者處併入。舉例而言,在一些實施例中,嵌合聚合酶亦可包括以下胺基酸取代中之一或多者:M8R、V51A、N62D、I71V、L107I及/或K131E,及/或以下胺基酸取代中之一或多者:K135Q、L142K、G197D、Y224K、E239G、V250A、V250I、L253A、L253H、Y281H、I288L、T301C、R306Q、R308L、D325E、D341E、K354R、T368F、E375Y、A437G、A444T、E466K、D476H、A484E、E508R、D510K、D510R、K512Y、E515Q、K539E、D570S及/或T571V。
在其他實施例中,一或多個胺基酸變化可在位置中之一或多者處併入:關於屎腸球菌聚合酶(SEQ ID NO: 2)之K4、T13、S22、V25、C26、D27、N33、I34、F36、S42、D54、N59、E60、E65、E85、M95、N106、T110、T114、K119、Q122、Y133、P136、E139、E142、N145、P147、I148、E152、I153、P160、D167、D171、N175、F188、D189、Q206、T211、S216、R217、D232、A236、V247、I253、V261、L264、S267、P273、P275、R308、V315、Q317、S319、L320、I322、Q323、D337、E338、D341、T345、F352、F353、T364、D374、I384、E385、N388、E391、A396、N397、G400、D414、D425、R429、E436、L437、V443、L445、A446、S447、V449、T450、W452、G453、Y455、F465、N467、T479、E482、A484、E485、A486、L490、D492、S493、K495、K500、S503、Q506、Q513、E519、D521、E523、V526、D533、R534、E537、G547、E545、L555、P556、R558、T559、V564、T568、M569及/或T571。在一些實施例中,嵌合聚合酶亦可包括以下胺基酸取代中之一或多者:K4R、T13N、S22A、V25L、C26W、D27E、N33T、I34V、F36V、S42T、D54Y、N59D、E60L、E60V、E65S、E85P、M95T、M95K、N106G、T110I、T114S、K119Q、Q122V、Y133L、P136T、E139K、E139Q、E139R、E139H、E142K、E142Q、E142R、E142H、N145K、N145H、N145R、P147Q、P147T、I148K、I148H、I148R、E152D、I153V、P160A、D167P、D167K、D167H、D167R、D171K、D171H、D171R、N175T、N175Y、F188C、D189K、D189H、D189R、Q206R、Q206K、Q206H、T211A、S216G、S216R、R217G、D232K、A236G、V247D、I253H、I253A、V261A、V261I、V261L、L264H、L264A、L264M、S267A、P273S、P273R、P275S、E283K、V315L、S319R、R308G、G308R、Q317R、S319R、L320M、L320T、I322K、Q323G、Q323V、Q323R、D337G、E338K、D341T、T345I、F352I、F353C、T364I、D374G、D374Q、D374H、I384T、I384F、I384S、E385Y、E385K、E385R、E385N、E385Q、E385L、E385A、N388T、E391Y、E391W、E391F、E391H、E391M、E391K、E391R、A396Q、N397L、G400L、D414V、D425N、R429G、E436R、E436G、L437Y、L437E、V443T、L445M、A446G、S447V、V449I、T450A、W452Y、G453A、Y455W、F465Y、N467R、N467K、N467H、N467S、N467T、T479V、E482K、E482H、E482R、A484E、E485D、A486E、L490M、D492H、D492K、D492R、D492A、H492S、S493P、K495R、K500E、S503A、S503T、Q506K、Q513D、D521K、D521R、D521H、E523R、E523V、E523Y、E523F、E523H、E523W、V526L、D533A、D533Q、D533T、D533R、D533S、R534K、E537K、E537H、E537R、E545K、E545H、E545R、G547S、L555K、L555R、P556A、R558H、T559V、V564L、T568D、T568S、M569K、M569T、M569V及/或T571S。 表2.屎腸球菌聚合酶變異體
名稱 SEQ ID NO: 序列
EFM0 34 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWKHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM36 35 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM37 36 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM38 37 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWFEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM39 38 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWFEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM40 39 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM41 40 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM42 41 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWFEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM43 42 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWFEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM44 43 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWFEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWKHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM45 44 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWFEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWKHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM46 45 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWFEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWKHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM47 46 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWFEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWKHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM48 47 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWFEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWKHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM49 48 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWFEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWKHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM50 49 MIKRYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWKHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM51 50 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKKLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWKHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM52 51 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWKHESTFQRAKFIRDKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM53 52 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWKHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM54 53 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWKHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM55 54 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELITLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWKHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM56 55 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVGELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWKHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM57 56 MIKKYTGDFETTTDLNDCRVWAWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWKHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM58 57 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEPRTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWKHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM59 58 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKATYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWKHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM60 59 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWGVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWKHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM61 60 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKVRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWKHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM62 61 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLVGTEVPEAIEHLVDSKKLGYWKHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM63 62 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDPKKLGYWKHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM64 63 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKKIAKAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWKHESTFQRAKFIRQKTYVEEIKGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM65 64 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWKHESTFQRAKFIRQKTYVEEIDGKLNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM66 65 MIKKYTGDFETTTDLNDCRVWAWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVGELITLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWKHESTFQRAKFIRQKTYVEEIDGKLNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM67 66 MIKRYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKKIAKAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKKLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWFEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRDKTYVEEIKGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM68 67 MIKRYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKKIAKAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKKLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWFEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRDKTYVEEIKGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM69 68 MIKRYTGDFETTTDLNDCRVWAWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDLKFDGEFMLSWLFKNGFKWCKEAKEPRTFSTLISNMGQWYALEICWGVKCTTTKTGKTKKEKVRTIIYDSLKKYPFPVKQIAKAFNFPKKKGEIDYTKERPIGYNPTPDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKATYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWFEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLVGTKVPEAIEHLVHPKKLGYWEHESTFQRAKFIRDKTYVEEIKGKLNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM70 69 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM71 70 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM72 71 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWFEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM73 72 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWFEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM74 73 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM75 74 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM76 75 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWFEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM77 76 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWFEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM78 77 MIKKYTGDFETTTDLNDCRVWAWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVGELITLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM79 78 MIKKYTGDFETTTDLNDCRVWAWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVGELITLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM80 79 MIKKYTGDFETTTDLNDCRVWAWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVGELITLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWFEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM81 80 MIKKYTGDFETTTDLNDCRVWAWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVGELITLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWFEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM82 81 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM83 82 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM84 83 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWFEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM85 84 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWFEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM86 85 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWKYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM87 86 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKKIAEAFNFPKKKGEIDYTKERPIGYNPTDDEWKYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIDGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM88 87 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKKIAEAFNFPKKKGEIDYTKERPIGYNPTDDEWKYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM89 88 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM90 89 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPKKKGEIDYTKERPIGYNPTPDEWKYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIDGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM91 90 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTPDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM92 91 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWKYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM93 92 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKKIAEAFNFPKKKGEIDYTKERPIGYNPTPDEWKYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM94 93 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTPDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIDGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM95 94 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPKKKGEIDYTKERPIGYNPTPDEWKYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM96 95 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM97 96 MHHHHHHHHHHDYDIPTTENLYFQGMIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWKHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM98 97 MHHHHHHHHHHDYDIPTTENLYFQGMIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWKHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM99 98 MHHHHHHHHHHDYDIPTTENLYFQGMIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM100 99 MHHHHHHHHHHDYDIPTTENLYFQGMIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWFEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWKHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM101 100 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKKIAEAFNFPKKKGEIDYTKERPIGYNPTDDEWKYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM102 101 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM103 102 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTPDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIDGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM104 103 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFTVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM105 104 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSMFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM106 105 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDKLIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM107 106 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGVLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM108 107 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFTVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWKYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM109 108 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWKYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSMFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM110 109 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWKYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDKLIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM111 110 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWKYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGVLNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM112 111 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM113 112 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM114 113 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSMFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM115 114 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSMFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM116 115 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSMFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM117 116 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSMFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM118 117 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSMFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM119 118 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSMYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSMFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM120 119 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSMYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSMFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM121 120 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSMYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSMFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM122 121 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSMFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM123 122 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSMFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM124 123 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSMFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM125 124 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEDIYAKRVRGYLIECSPDEATTTKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM126 125 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEDIYMKRVRGYLVQGSPDDYTDIKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM127 126 MIKKYTGDFETTTDLNDCRVWAWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM128 127 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELITLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM129 128 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVGELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM130 129 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM131 130 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEPRTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM132 131 MIKKYTGDFETTTDLNDCRVWAWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVGELITLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM133 132 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSMFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWKHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM134 133 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSMFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM135 134 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSMFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM136 135 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSMFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM137 136 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSMFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM138 137 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSMFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIDGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM139 138 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSMFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM140 139 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSMFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM141 140 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSMFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM142 141 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSMFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM143 142 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSMFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWFEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM144 143 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSMFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWSEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
EFM145 144 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM146 145 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM147 146 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM148 147 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM149 148 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSMYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM150 149 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSMYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM151 150 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSMYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM152 151 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM153 152 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM154 153 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM155 154 MIKKYTGDFETTTDLNDCRVWAWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM156 155 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELITLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM157 156 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVGELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM158 157 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM159 158 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEPRTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM160 159 MIKKYTGDFETTTDLNDCRVWAWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVGELITLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM161 160 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWKHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM162 161 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM163 162 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM164 163 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM165 164 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM166 165 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIDGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM168 166 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM169 167 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM170 168 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM171 169 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM172 170 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM173 171 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSMYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM174 172 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSMYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM175 173 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSMYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM176 174 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM177 175 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM178 176 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM179 177 MIKKYTGDFETTTDLNDCRVWAWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM180 178 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELITLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM181 179 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVGELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM182 180 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM183 181 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEPRTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM184 182 MIKRYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM185 183 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRDKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM186 184 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKKLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM187 185 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWKHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM188 186 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM189 187 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM190 188 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM191 189 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM192 190 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIDGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM193 191 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM194 192 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM195 193 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM196 194 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWFEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM197 195 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWSEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM198 196 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDDTFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM199 197 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDSVFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM200 198 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLAKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM201 199 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGSFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM202 200 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEERLRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM203 201 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAYGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM204 202 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRWTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM205 203 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAYGRWTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM206 204 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEEYRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM207 205 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEEERDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM208 206 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHEATFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM209 207 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWARYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM210 208 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKLPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM211 209 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM212 210 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGKLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLKPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM213 211 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM232 212 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKLPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM233 213 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM234 214 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM235 215 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM236 216 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAYGRWTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM237 217 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKLPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM238 218 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKLPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM239 219 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKLPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM240 220 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKLPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAYGRWTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM241 221 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM242 222 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM243 223 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAYGRWTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM244 224 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM245 225 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAYGRWTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM246 226 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAYGRWTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM247 227 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKLPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM248 228 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKLPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM249 229 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKLPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAYGRWTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM250 230 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKLPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM251 231 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKLPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAYGRWTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM252 232 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKLPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAYGRWTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM253 233 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM254 234 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAYGRWTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM255 235 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAYGRWTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM256 236 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAYGRWTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM257 237 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKLPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM258 238 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKLPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAYGRWTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM259 239 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKLPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAYGRWTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM260 240 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKLPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAYGRWTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM261 241 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAYGRWTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM262 242 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKLPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAYGRWTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM263 243 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDLNSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM264 244 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVKSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM265 245 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVASKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM266 246 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVSSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM267 247 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM268 248 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWFEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM269 249 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWSEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM270 250 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDLNSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM271 251 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM272 252 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKLPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM273 253 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM274 254 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM275 255 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAYGRWTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM276 256 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKLPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM277 257 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKLPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM278 258 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKLPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAYGRWTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM279 259 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM280 260 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAYGRWTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM281 261 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAYGRWTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM282 262 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKLPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM283 263 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKLPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAYGRWTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM284 264 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKLPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAYGRWTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM286 265 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAYGRWTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM287 266 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKLPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAYGRWTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM288 267 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDLNSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM289 268 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVKSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM290 269 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVASKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM291 270 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVSSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM292 271 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM293 272 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWFEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM294 273 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDINSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWSEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM295 274 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM296 275 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGENGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM297 276 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVGLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM298 277 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGENGIVGLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM299 278 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNTGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM300 279 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDKIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM301 280 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAQAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM302 281 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFKFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM303 282 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKKIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM304 283 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKQIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM305 284 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYRDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM306 285 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYKDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM307 286 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDRIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM308 287 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIGNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM309 288 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPVITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM310 289 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKRSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM311 290 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSRLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM312 291 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFKQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM313 292 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIGNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM314 293 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKRSRLFKGNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM315 294 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYTPLASFVAAYGRWTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM316 295 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYTPMGVFITAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM317 296 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFKVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM318 297 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCYDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM319 298 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGWLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM320 299 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFRQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM321 300 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIARAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM322 301 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKRLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM323 302 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIYVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM324 303 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCGMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM325 304 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIKGYLNVKCAGMPARIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
EFM326 305 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNLKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAKAFNFPKKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFKQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTWGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTKVPEAIEHLVHSKKLGYWEHESTFQRAKFIRQKTYVEEIRGYLNVKCAGMPDRIKKLVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIKGHHHHHHHHHHGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE
表3.同源聚合酶變異體
名稱 SEQ ID NO 序列
H008 306 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDIHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDILSTKKFNKVFPKLSLPMDKEIRKAYRGGFTWLNDKYKEKEIGEGMVFDVNSLYPSQMYSRPLPYGAPIVFQGKYEKDEQYPLYIQRIRFEFELKEGYIPTIQIKKNPFFKGNEYLKNSGVEPVELYLTNVDLELIQEHYELYNVEYIDGFKFREKTGLFKDFIDKWTYVKTHEEGAKKQLAKLMLNSLYGKFASNPDVTGKVPYLKDDGSLGFRVGDEEYKDPVYTPMGVFITAWARFTTITAAQACYDRIIYCDTDSIHLTGTEVPEIIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYVKEVDGKLKECSPDEATTTKFSVKCAGMTDTIKKKVTFDNFAVGFSSMGKPKPVQVNGGVVLVDSVFTIK
H009 307 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDIHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDILSTKKFNKVFPKLSLPMDKEIRKAYRGGFTWLNDKYKEKEIGEGMVFDANSAYPSQMYSRPLPYGAPIVFQGKYEKDEQYPLYIQRIRFEFELKEGYIPTIQIKKNPFFKGNEYLKNSGVEPVELYLTNVDLELIQEHYELYNVEYIDGFKFREKTGLFKDFIDKWTYVKTHEEGAKKQLAKLMLNSLYGKFASNPDVTGKVPYLKDDGSLGFRVGDEEYKDPVYTPMGVFITAWARFTTITAAQACYDRIIYCDTDSIHLTGTEVPEIIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYVKEVDGKLKECSPDEATTTKFSVKCAGMTDTIKKKVTFDNFAVGFSSMGKPKPVQVNGGVVLVDSVFTIK
H010 308 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDIHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDILSTKKFNKVFPKLSLPMDKEIRKAYRGGFTWLNDKYKEKEIGEGMVFDANSAYPSQMYSRPLPYGAPIVFQGKYEKDEQYPLYIQRIRFEFELKEGYIPTIQIKKNPFFKGNEYLKNSGVEPVELYLTNVDLELIQEHYELYNVEYIDGFKFREKTGLFKDFIDKWTYVKTHEYGAKKQLAKLMLNSLYGKFASNPDVTGKVPYLKDDGSLGFRVGDEEYKDPVYTPMGVFITAWARFTTITAAQACYDRIIYCDTDSIHLTGTEVPEIIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYVKEVDGYLKECSPDEATTTKFSVKCAGMTDTIKKKVTFDNFAVGFSSMGKPKPVQVNGGVVLVDSVFTIK
H011 309 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDILSTKKFNKVFPKLSLPMDKEIRKAYRGGFTWLNDKYKEKEIGEGMVFDANSAYPSQMYSRPLPYGAPIVFQGKYEKDEQYPLYIQRIRFEFELKEGYIPTIQIKKNPFFKGNEYLKNSGVEPVELYLTNVDLELIQEHYELYNVEYIDGFKFREKTGLFKDFIDKWTYVKTHEYGAKKQLAKLMLNSLYGKFASNPDVTGKVPYLKDDGSLGFRVGDEEYKDPVYTPMGVFITAWARFTTITAAQACYDRIIYCDTDSIHLTGTEVPEIIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYVKEVDGYLKECSPDEATTTKFSVKCAGMTDTIKKKVTFDNFAVGFSSMGKPKPVQVNGGVVLVDSVFTIK
H012 310 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDITKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
H013 311 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDITKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
H014 312 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDITKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
H016 313 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDIHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDILSTKKFNKVFPKLSLPMDKEIRKAYRGGFTWLNDKYKGKEIGEGMVFDINSAYPSQMYSRPLPYGAPIVFQGKYEKDEQYPLYIQRIRFEFELKEGYIPTIQIKKNPFFKGNEYLKNSGVEPVELYLTNVDLELIQEHYELYNVEYIDGFKFREKTGLFKDFIDKWTYVKTHEYGAKKQLAKLMLNSLYGKFASNPDVTGKVPYLKDDGSLGFRVGDEEYKDPVYTPMGVFITAWGRFTTITAAQACYDRIIYCDTDSIHLTGTEVPEIIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYVKEVKGYLKQCSPDEATTTKFSVKCAGMTDTIKKKVTFDNFAVGFSSMGKPKPVQVNGGVVLVDSVFTIK
H018 314 MKHMPRKMYSCDFETTTDVNDCRVWAYGWMEIGKTSNYKIGTDFNEFMEWMIHSSSRLYFHDLKFDGSFIVNWLLHNGYTWTKRPSKEGQFSTLISKMGQWYGITICSGRDGRKKKLTTIHDSLKKLPFPVRKIGKDFKLNVLKGDIDIHKPRPIGYEIDDEEYQYIKNDIQIIAEALEVQTVQGLTGMTNGKDALDEFVNMSGKLYEKLFPVFSLELNEEIRKAYRGGFTWLNPVYGGKKYVKDGIVFDANSAYPSQMYDRDLPCGVPIPFEGEYVYDKSHPLYIQKLTFEFELKENYIPTIQLKNSRFGFKGNEYLSSSNGERITISVSSVDWELIREHYHVYDVEFEKGWKFRSTKQAFRQYIDKWMLVKNMSYGAKKAIAKLMLNSLYGKFATNPDITGKRPYLREDGSNGFELMEEEFRDPVYTPVGIFITSWARYTTITSAQKCYDRIIYCDTDSMHLEGLDVPESIKDIVADDVLGYWEKEGQFKQGKFIRQKTYMEEYYAKYVRDENGEIKYDDEKPYKTICDKEESDTTIIEIKCAGMPDNIKKHVTFDNFDIGFTMEGKLKPKQVYGGVVLVEETYTMK
H020 315 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDITKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
H022 316 MATKKRKAYSCDFEATTSTYSETETRVWAYGWMEIGNTSHFNIGDNLDEFMLWTSKECADLYFHDLRYDGEFIVNWLLHKGYECNESGRPKTFDTVISKGGQWYKIAIHHEGKGTTQIFDSLKKLPFPVKTIAKAFKLPVLKGDIDINLHRDENHVITSEEFTYIKHDIEIVARALDIQINQQGLVKMTNGADSMDHFIKSLDKKKKVAERIYNQYFPKMSIAMDSIFRKAYRGGFTWVNPKFKGQEVGEGMVFDANSAYPSVMYYKPLPWGKPVPFVGKYEEDPDFPLYICHIKTGFVLKEGHIPTIQIKKNPIFQENEYLETSGGAPVDLHVTNVDLELIKEHYELYDTEYVGGWKFRQQTGIFNNFIDYWMKIKTDPKSTPAIVTLAKLQLNSLYGKFASHPDVTGKVPYLKDDGSTAFKKGLPKSKDPVYTPAGAFITAWARHMTITTAQKVYDRILYCDTDSIHILGIDIPEAIKNDIHQKELGKWEFECMFKRAKFVRQKTYVEDMYAKFMKYWEDGELNYYLKECVKEEATARLLNVKCAGMPQAVKKFVTFRTFAVGFTSDTGKLKPKHVKGGQILVDVPFTIK
QTD6 317 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWKHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
H026 318 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDITKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWKHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
H027 319 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDITKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
H028 320 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDITKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWKHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
H029 321 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDITKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSAYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWKHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
H030 322 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDITKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWKHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
H031 323 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDITKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
H032 324 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDITKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWTEVKTTTYGARKQLAKLMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDPKKLGYWEHESTFKRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
H033 325 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDITKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTYGARKQNAKLMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYVEEIDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
H034 326 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDITKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDYQDWVKTTYGKSRFKQWFPVLSLGFDKDLRKAYKGGFTWVNKVFQGKEIGEGIVFDVNSLYPSQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWKHESTFQRAKFIRQKTYVEEIYMKRVKGYLVQGSPDDYTDGELNVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
H037 327 MGNKKRKIYSCDFETTTDVNDCRVWAYGLMEIDGKFENYKEGNNIDEFMEWTEQEQGDLYFHNLRFDGEFIVNWLLHKGYRFNNTRKAGTFNAVISSMGQWYKIDIYYGREGKKVFKTSIYDSLKKLPFPVKTIAKAFKLPIEKGDIDYDAPRPVGHQITPDESKYIKNDVEIIARALHSQLNTAKLTKMTIGSDALDGFKHSLHKSPKVSKRMYDHHFPVISNAIHEEFKKAYRGGFTWANPKYAGKVIGNGLVFDVNSLYPSVMYDKPLPYGLPVPFSGEYEYDETHPLFIQHIKCGFELKDGHIPTIQIKKNFRFADNEYLHSSEGNILDLHVTNVDLALIKEHYTLYEEEYLQGYKFKQVTGLFKNYIDYWSDKKINAEDPAIRQMAKLMLNSLYGKFGTSIDVTGKEVFLKEDGSTGFRKGQKEERDPVYMPMGAFITAYARDVTIRTAQKCYDRILYCDTDSIHLVGTEIPEAIKDRIHDKKLGYWAHESTFWRAKFIRQKTYIEDLCMRFEGEKVNGEWKFKMVEEKDITKATARELSVKCAGMPAQVKQYVTFDNFGVDFKHDPNDYTDEEIKRKNIKFKLKPTHRKGGQVLVPTPFTIK
Q001 328 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
Q002 329 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
Q003 330 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSKGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
Q004 331 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRQKTYIQDIYMKRVKGKLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
Q005 332 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWCHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
Q006 333 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIRQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
Q007 334 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKRLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
Q008 335 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDARSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
Q009 336 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDDKKLGYWAHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
Q010 337 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
Q011 338 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPDKLGYWAHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
Q012 339 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAFRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
Q013 340 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFKLTVLKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRYAYRGGFTWLNDRFKEKEIGEGMVFDVNSLYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSEGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWARYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKEVDGKLVEGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDDTFTIK
Q014 341 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFKLTVLKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRYAYRGGFTWLNDRFKEKEIGEGMVFDVNSLYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSEGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWARYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWCHESTFKRAKYLRQKTYIQDIYMKEVDGKLVEGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDDTFTIK
Q015 342 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFKLTVLKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRYAYRGGFTWLNDRFKEKEIGEGMVFDVNSLYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSEGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWARYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWSHESTFKRAKYLRQKTYIQDIYMKEVDGKLVEGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDDTFTIK
Q016 343 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFKLTVLKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRYAYRGGFTWLNDRFKEKEIGEGMVFDVNSLYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSEGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWARYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWTHESTFKRAKYLRQKTYIQDIYMKEVDGKLVEGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDDTFTIK
Q017 344 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFKLTVLKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRYAYRGGFTWLNDRFKEKEIGEGMVFDVNSLYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSEGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWARYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWNHESTFKRAKYLRQKTYIQDIYMKEVDGKLVEGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDDTFTIK
Q018 345 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFKLTVLKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRYAYRGGFTWLNDRFKEKEIGEGMVFDVNSLYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSEGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWARYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWQHESTFKRAKYLRQKTYIQDIYMKEVDGKLVEGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDDTFTIK
Q019 346 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFKLTVLKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRYAYRGGFTWLNDRFKEKEIGEGMVFDVNSLYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSEGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWARYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRQKTYIQDIYMKEVDGKLVEGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDDTFTIK
Q020 347 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDVNSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRQKTYIQDIYMKRVKGKLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
Q021 348 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWNHASTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
Q022 349 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWQHASTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
Q023 350 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKFGYWAHASTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
Q024 351 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMKSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHASTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
Q025 352 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPSQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHASTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
Q026 353 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWFYIKDTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHASTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
Q027 354 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWFYIKTTSYGAWKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHASTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
Q028 355 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWFYIKTTSYGAIKQWAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHASTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
Q029 356 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWFYIKTTSYGAIKQLAKLFLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHASTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
Q030 357 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKAFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHASTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
Q031 358 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWFYIKTRSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHASTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
Q032 359 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWDYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKKGYWAHASTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
Q033 360 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWEYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKKGYWAHASTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
Q034 361 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSAYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
Q035 362 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKQSLFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
Q036 363 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
Q037 364 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDVNSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWFYIKTTSEGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRQKTYIQDIYMKRVKGKLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
Q038 365 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRYAYRGGFTWLNDRFKEKEIGEGMVFDVNSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRQKTYIQDIYMKRVKGKLVEGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
Q039 366 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFKLTVLKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDVNSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRQKTYIQDIYMKEVDGKLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
Q040 367 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFKLTVLKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRYAYRGGFTWLNDRFKEKEIGEGMVFDVNSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRQKTYIQDIYMKEVDGKLVEGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
Q041 268 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFKLTVLKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRYAYRGGFTWLNDRFKEKEIGEGMVFDVNSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWFYIKTTSEGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRQKTYIQDIYMKEVDGKLVEGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
Q042 369 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFKLTVLKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRYAYRGGFTWLNDRFKEKEIGEGMVFDVNSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWFYIKTTSEGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRQKTYIQDIYMKEVDGKLVEGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDDTFTIK
Q043 370 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFKLTKLKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRYAYRGGFTWLNDRFKEKEIGEGMVFDVNSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKNSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWFYIKTTSEGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRQKTYIQDIYMKHVDGKLVEGSPDDYTKIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDDTFTIK
Q044 371 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFKLTKLKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRYAYRGGFTWLNDRFKEKEIGEGMVFDVNSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKNSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWFYIKTTSEGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRQKTYIQDIYMKHVHGKLVEGSPDDYTKIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDDTFTIK
Q045 372 MKHMPRKRYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFKLTVLKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRYAYRGGFTWLNDRFKEKEIGEGMVFDVNSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWFYIKTTSEGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRPKTYIQDIYMKEVDGKLVEGSPDDYTDIKLSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDDTFTIK
Q046 373 MKHMPRKRYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFKLTKLKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRYAYRGGFTWLNDRFKEKEIGEGMVFDVNSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKNSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWFYIKTTSEGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRPKTYIQDIYMKHVDGKLVEGSPDDYTKIKLSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDDTFTIK
Q047 374 MKHMPRKRYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFKLTKLKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRYAYRGGFTWLNDRFKEKEIGEGMVFDVNSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKNSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWFYIKTTSEGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRPKTYIQDIYMKHVHGKLVEGSPDDYTKIKLSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDDTFTIK
Q048 375 MKHMPRKRYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFKLTKLKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRYAYRGGFTWLNDRFKEKEIGEGMVFDVNSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKNSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWFYIKTTSEGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRPKTYIQDIYMKNVNGKLVEGSPDDYTKIKLSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDDTFTIK
Q049 376 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFKLTKLKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRYAYRGGFTWLNDRFKEKEIGEGMVFDVNSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKNSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWFYIKTTSEGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRPKTYIQDIYMKHVHGKLVEGSPDDYTKIKLSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDDTFTIK
Q050 377 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFKLTKLKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRYAYRGGFTWLNDRFKEKEIGEGMVFDVNSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKNSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWFYIKTTSEGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRPKTYIQDIYMKNVNGKLVEGSPDDYTKIKLSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDDTFTIK
Q051 378 MKHMPRKRYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFKLTKLKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRYAYRGGFTWLNDRFKEKEIGEGMVFDVNSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKNSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRPKTYIQDIYMKHVDGKLVEGSPDDYTKIKLSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDDTFTIK
Q052 379 MKHMPRKRYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFKLTKLKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRYAYRGGFTWLNDRFKEKEIGEGMVFDVNSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKNSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRPKTYIQDIYMKHVHGKLVEGSPDDYTKIKLSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDDTFTIK
Q053 380 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFKLTKLKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRYAYRGGFTWLNDRFKEKEIGEGMVFDVNSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKNSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRQKTYIQDIYMKHVDGKLVEGSPDDYTKIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDDTFTIK
Q054 381 MKHMPRKRYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFKLTKLKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRYAYRGGFTWLNDRFKEKEIGEGMVFDVNSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKNSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRPKTYIQDIYMKHVHGKLVNGSPDDYTKIKLSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDDTFTIK
Q055 382 MKHMPRKRYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFKLTKLKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRYAYRGGFTWLNDRFKEKEIGEGMVFDVNSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKNSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRPKTYIQDIYMKHVDGKLVNGSPDDYTKIKLSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDDTFTIK
表4.嵌合聚合酶變異體
名稱 SEQ ID NO 序列
C001 383 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEQYPLYIQRIRFEFELKEGYIPTIQIKKNPFFKGNEYLKNSGVEPVELYLTNVDLELIQEHYELYNVEYIDGFKFRETTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C002 384 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKKNPFFKGNEYLKNSGVEPVELYLTNVDLELIQEHYELYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C003 385 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKKNPFFKGNEYLKNSGVEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C004 386 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRILPYGDPIVFDGKYVWDDEYPLHIQHIRCEFELKDGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C005 387 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRILPYGDPIVFDGKYVWDDEYPLHIQHIRCDFELKDGYIPTIQIKRSRFYKGNEYLKSSGGDLVELWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C006 388 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRILPYGDPIVFDGKYVWDDEYPLHIQHIRCDFELKDGYIPTIQIKRSRFYKGNEYLKSSGGDLVELWISQVDIDLMKEHYELYNVEYLSGIKFRATTGIFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C007 389 MSRKMFSCDFETTTRLDDCRVWAYGYMEIGNLDNYKLGNSLDEFMQWVMEINADLYFHDLKFDGAFLVNWLEQHGFRWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C008 390 MSRKMFSCDFETTTRLDDCRVWAYGYMEIGNLDNYKLGNSLDEFMQWVMEINADLYFHDLKFDGAFLVNWLEQHGFRWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRILPYGDPIVFDGKYVWDDEYPLHIQHIRCDFELKDGYIPTIQIKRSRFYKGNEYLKSSGGDLVELWISQVDIDLMKEHYELYNVEYLSGIKFRATTGIFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C009 391 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRILPYGDPIVFDGKYVWDDEYPLHIQHIRCDFELKDGYIPTIQIKRSRFYKGNEYLKSSGGELVELYVTNIDLDLIKEHYELYNVEYLSGLKFRATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C010 392 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C011 393 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C012 394 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C013 395 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C014 396 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C015 397 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C016 398 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C017 399 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C018 400 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRPLPYGAPIVFQGKYEKDEQYPLYIQRIRFEFELKEGYIPTIQIKKNPFFKGNEYLKNSGVEPVELYLTNVDLELIQEHYELYNVEYIDGFKFREKTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C019 401 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRPLPYGAPIVFQGKYEKDEQYPLYIQRIRFEFELKEGYIPTIQIKKNPFFKGNEYLKNSGVEPVELYLTNVDLELIQEHYELYNVEYIDGFKFREKTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C020 402 MKHMPRKMYSCDFETTTDVNDCRVWAYGWMEIGKTSNYKIGTDFNEFMEWMIHSSSRLYFHDLKFDGSFIVNWLLHNGYTWTKRPSKEGQFSTLISKMGQWYGITICSGRDGRKKKLTTIHDSLKKLPFPVRKIGKDFKLNVLKGDIDYHKPRPIGYEIDDEEYQYIKNDIQIIAEALEVQTVQGLTGMTNGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C021 403 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYDRDLPCGVPIPFEGEYVYDKSHPLYIQKLTFEFELKENYIPTIQLKNSRFGFKGNEYLSSSNGERITISVSSVDWELIREHYHVYDVEFEKGWKFRSTKQAFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C022 404 MKHMPRKMYSCDFETTTDVNDCRVWAYGWMEIGKTSNYKIGTDFNEFMEWMIHSSSRLYFHDLKFDGSFIVNWLLHNGYTWTKRPSKEGQFSTLISKMGQWYGITICSGRDGRKKKLTTIHDSLKKLPFPVRKIGKDFKLNVLKGDIDYHKPRPIGYEIDDEEYQYIKNDIQIIAEALEVQTVQGLTGMTNGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYDRDLPCGVPIPFEGEYVYDKSHPLYIQKLTFEFELKENYIPTIQLKNSRFGFKGNEYLSSSNGERITISVSSVDWELIREHYHVYDVEFEKGWKFRSTKQAFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C023 405 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAFRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C024 406 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHNEKFDGEFMLSWLFKNGFKWCKEAKEERTFSTLISNMGQWYALEICWNVKCTTTKTGKTKKEKQRTIIYDSLKKYPFPVKEIAEAFNFPIKKGEIDYTKERPIGYNPTDDEWDYLKNDIQIMAMALKIQFDQGLTRMTRGSDALGDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C025 407 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEVPEAIEHLVDSKKLGYWEHESTFQRAKFIRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C026 408 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEVPEAIEHLVDPKKLGYWEHESTFQRAKFIRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C027 409 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYVKKVRGYLVQCSPDEATTTKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C028 410 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEVPEAIEHLVDPKKLGYWEHESTFQRAKFIRQKTYIQDIYVKKVRGYLVQCSPDEATTTKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C029 411 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C030 412 MIKKYTGDFETTTDLNDCRVWSWGVCDIDNVDNITFGLEIDSFFEWCEMQGSTDIYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C031 413 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C032 414 MVRQSTIASPARGGVRRSHKKVPSFCADFETTTDEDDCRVWSWGIIQVGKLQNYVDGISLDGFMSHISERASHIYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C033 415 MNEYISDFETQKDPDTGVMSVWAWSIVDVNDLSNIQYGNNIESWLSAIQGLPNGSLIGFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C034 416 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C035 417 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKGWIDKWIEVKNTTEGARKANAKGMLNSLYGKFGTNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
C036 418 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEELRDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
C037 419 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIYSEGAPRTNRPLYIASITFTAKLKPNHIPCIQIKKNLSFNPTQYLEEVKEPTTVVATNIDIELWKKHYDFKIYSWNGTFEFRGSHGFFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C038 420 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPIGTPVFFEGKYKDDPIYPLYIQFITAQFELKKGKIPTIQIKNDKRFNPREYVTSTGCLMVNLYLTNVDLEMFYECYNIKEIQYIGGYKFIGRSGIFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C039 421 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C040 422 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C041 423 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLERNGFKWSNEGLPNTYNTIISKMGQWYMIDICIGYKGKRKLHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C042 424 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLERNGFKWSNEGLPNTYNTIISKMGQWYMIDICIGYKGKRKLHTVIYDSLKKLPFPVEKIAKDFQLTLKKGDIDIHKERPVGYEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C043 425 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYVKEVDGKLKECSPDEATDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C044 426 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYVKRVDGYLVECSPDEYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C045 427 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C046 428 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C047 429 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYVKEVDGKLKECSPDEATDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C048 430 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYVKEVDGKLKECSPDEATDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C049 431 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYVKRVDGYLVECSPDEYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C050 432 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYVKRVDGYLVECSPDEYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C051 433 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYVKEVDGKLKECSPDEATDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C052 434 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYVKRVDGYLVECSPDEYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C053 435 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C054 436 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C055 437 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYVKEVDGKLKECSPDEATDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C056 438 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYVKEVDGKLKECSPDEATDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C057 439 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYVKRVDGYLVECSPDEYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C058 440 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYVKRVDGYLVECSPDEYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C059 441 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEETKDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYVKRVDGYLVECSPDEYTDIKFSVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
C060 442 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEETKDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYVKRVDGYLVECSPDEYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C061 443 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYVKRVDGYLVECSPDEYTDIKFSVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
C062 444 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEETKDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYVKEVDGKLKECSPDEATDIKFSVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
C063 445 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEETKDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYVKEVDGKLKECSPDEATDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C064 446 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYVKEVDGKLKECSPDEATDIKFSVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
C065 447 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPTIQVKQNSLFIQNEYLENSVNKLGVDELIDLTLTNVDLDLFFEHYEILEIHFTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C066 448 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPCIQVKQSSLFIQTEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHFTYGYMFRGSCDMFKDFIDKFTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C067 449 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIQYPLYIQNIKVRFRLKERHIPTIQVKQNSLFIQNEYLENSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRGSCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C068 450 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQTEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRGSCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C069 451 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIQYPLYIQNIKVRFRLKERHIPTIQVKQNSLFIQTEYLENSVNKLGVDELIDLTVTNVDLDLFFEHYDILEIHFTYGYMFKASCDMFKDFIDKFTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C070 452 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQTEYLESSVNKLGVDELIDLTVTNVDLDLFFEHYDILEIHFTYGYMFKASCDMFKDFIDKFTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C071 453 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIQHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQTEYLENSVNKLGVDELIELTVTNVDLDLFFEHYEILEIHFTYGYMFRGSCDMFKDFIDKFTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C072 454 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIQYPLYIQNLKVRFRLKERHIPTIQVKQNSLFIQTEYLENSVNKLGVDELIELTVTNVDLDLFFEHYEILEIHFTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C073 455 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDYPLYIQNIKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C074 456 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIQYPLYIQNIKVRFRLKERHIPTIQVKQNSLFIQNEYLENSVNKLGVDELIDLTVTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C075 457 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIQYPLYIQNIKVRFRLKERHIPTIQVKQNSLFIQNEYLENSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C076 458 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C077 459 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIDLTVTNVDLDLFFEHYDILEIHFTYGYMFKASCDMFKDFIDKFTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C078 460 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPTIQVKQNSLFIQNEYLENSVNKLGVDELIDLTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C079 461 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIQHPLYIQNLKVRFRLKERHIPTIQVKQNSLFIQNEYLENSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C080 462 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIQYPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLENSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C081 463 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIQYPLYIQNLKVRFRLKERHIPTIQVKQNSLFIQNEYLENSVNKLGVDELIELTVTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C082 464 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIQHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLENSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C083 465 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIQHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLENSVNKLGVDELIELTVTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C084 466 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIQHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLENSVNKLGVDELIELTVTNVDLDLFFEHYEILEIHFTYGYMFRASCDMFKDFIDKFTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C085 467 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIQHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLENSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C086 468 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIQHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLENSVNKLGVDELIELTVTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C087 469 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLERNGFKWSNEGLPNTYNTIISKMGQWYMIDICIGYKGKRKLHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIQYPLYIQNLKVRFRLKERHIPTIQVKQNSLFIQNEYLENSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C088 470 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIQYPLYIQNLKVRFRLKERHIPTIQVKQNSLFIQNEYLENSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYVKEVDGKLKECSPDEATDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C089 471 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIQYPLYIQNLKVRFRLKERHIPTIQVKQNSLFIQNEYLENSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYVPLASFVTAWGRYTTITTAQRCFDNIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYVKRVDGYLVECSPDEYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C090 472 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEQHGFKWSNEGLPNTYNTIISKMGQWYMIDICFGYKGKRKLHTVIYDSLKKLPFPVKKIAKDFQLPLLKGDIDYHTERPVGHEITPEEYEYIKNDIEIIARALDIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIQYPLYIQNLKVRFRLKERHIPTIQVKQNSLFIQNEYLENSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYVKRVDGYLVECSPDEYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C091 473 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPTIQVKQNSLFIQNEYLENSVNKLGVDELIDLTLTNVDLDLFFEHYEILEIHFTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C092 474 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPCIQVKQSSLFIQTEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHFTYGYMFRGSCDMFKDFIDKFTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C093 475 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIQYPLYIQNIKVRFRLKERHIPTIQVKQNSLFIQNEYLENSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRGSCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C094 476 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQTEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRGSCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C095 477 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIQYPLYIQNIKVRFRLKERHIPTIQVKQNSLFIQTEYLENSVNKLGVDELIDLTVTNVDLDLFFEHYDILEIHFTYGYMFKASCDMFKDFIDKFTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C096 478 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQTEYLESSVNKLGVDELIDLTVTNVDLDLFFEHYDILEIHFTYGYMFKASCDMFKDFIDKFTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C097 479 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIQHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQTEYLENSVNKLGVDELIELTVTNVDLDLFFEHYEILEIHFTYGYMFRGSCDMFKDFIDKFTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C098 480 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIQYPLYIQNLKVRFRLKERHIPTIQVKQNSLFIQTEYLENSVNKLGVDELIELTVTNVDLDLFFEHYEILEIHFTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C099 481 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEKNGFKWSAEGLPNTYNTIISRMGQWYMIDICFGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0100 482 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEKNGFKWSAEGLPNTYNTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0101 483 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKLHTIIYDSLKKLPFPVEKIAKDFKLTLKKGDIDIHKERPIGYKITPDEYAYLKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0102 484 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEKNGFKWSAEGLPNTYNTIISRMGQWYMIDICFGYKGKRKLHTIIYDSLKKLPFPVEKIAKDFKLTLKKGDIDIHKERPIGYKITPDEYAYLKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0103 485 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEKNGFKWSAEGIPNTYNTIISRMGQWYMIDICFGYKGKRKLHTIIYDSLKKLPFPVEKIAKDFKLTLKKGDIDIHKERPIGYKITPDEYAYLKNDIQILAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0104 486 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLEQHGFKWSNEGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0105 487 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0106 488 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLLHNGYTWTKRPSKEGQFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0107 489 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLLHKGYECNESGRPKTFDTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0108 490 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLLKHGYRWTKENPGVKEFTTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0109 491 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0110 492 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLEKNGFKWTAEGEPNTYSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0111 493 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLLKNGFKWTAEGLPRTYSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0112 494 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLFKNGYKWTAEGLPNTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0113 495 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLEKNGYKWTAEGLPKTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0114 496 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLLRNGYVHTEEDRTNTPKEFTTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0115 497 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLFRLGYEFTDEKAPQVKEFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0116 498 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLLTDGWKWIPDKNDCANRTFTTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0117 499 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLLENGFKHSRERALYSNEFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0118 500 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLLGVAKWEYNDKPKARKAKTVETIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0119 501 MSRKMYSADFETTTKLDDCRVWSYGWMEVGNLDNYKIGNDIDEFMQWVMEIQSDLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0120 502 MSRKMYSCDFETTTKLDDCRVWAYGVMEVGNLDNYKIGNDIDEFMQWIMEIQSDLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0121 503 MSRKVFTADFETTTKLDDCRVWAYGWMEVGNLDNYKIGNSIDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0122 504 MSRKVYTADFETTTKLDDCRVWAYGWMEVGNLDNYKIGNSIDEFMQWIMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0123 505 MSRKMYTADFETTTKLDDCRVWAYGYMEVGNLDNYKIGNDIDEFMQWIMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0124 506 MSRKMYSADFETTTKLDDCRVWAYGYMEVGNLDNYKIGNSIDEFMQWIMEIQSDLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0125 507 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWFYIKTTSEGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0126 508 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWFYIKTTSEGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWNHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0127 509 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWFYIKTTSEGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWQHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0128 510 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWFYIKTRSEGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0129 511 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0130 512 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0131 513 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRFTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFDNFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0132 514 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0133 515 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIQYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRFTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFDNFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0134 516 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAQDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSHYPAQMYVRPLPYGTPLFYEGEYKENIQYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRFTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFDNFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0135 517 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0136 518 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIQYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRFTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFDNFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0137 519 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAQDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSHYPAQMYVRPLPYGTPLFYEGEYKENIQYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRFTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFDNFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0138 520 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0139 521 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0140 522 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0141 523 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0142 524 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0143 525 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIQHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRFTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFDNFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0144 526 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0145 527 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0146 528 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIQHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRFTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFDNFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0147 529 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAQDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSHYPAQMYVRPLPYGTPLFYEGEYKENIQHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRFTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFDNFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0148 530 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAQDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSHYPAQMYVRPLPYGTPLFYQGEYKENIQHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLENSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRFTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFDNFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0149 531 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIQHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLENSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRFTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFDNFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0150 532 MSRKRFSCDFETTTKLDDCRVWAYGYMEVGNLDNYKIGNSIDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIQHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLENSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRFTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFDNFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0151 533 MHKMSKKMFSCDFETTTKLDDCRVWAYGYMEVGNLDNYKIGNNIDEFMQWIMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0152 534 MHKMSRKMFSCDFETTTKLDDCRVWAYGYMEVGNLDNYKIGNSIDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0153 535 MSKKMFSCDFETTTKLDDCRVWAYGYMEVGNLDNYKIGNNIDEFMQWIMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0154 536 MSRKMFSCDFETTTKLDDCRVWAYGYMEVGNLDNYKIGNNIDEFMQWIMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0155 537 MSRKMFSCDFETTTKLDDCRVWAYGYMELGNLDNYKIGNNIDEFMQWIMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0156 538 MSRKMFSCDFETTTKLDDCRVWAYGYMELGNLDNYKIGNTIDEFMQWIMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0157 539 MSRKMFSCDFETTTKLDDCRVWAYGYMEVGNLDNYKIGNTIDEFMQWIMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0158 540 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNNIDEFMQWIMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0159 541 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNTIDEFMQWIMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0160 542 MSRKMFSCDFETTTKLDDCRVWAYGYMEVGNLDNYKIGNTLDEFMQWIMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0161 543 MSRKMFSCDFETTTKLDDCRVWAYGYMEVGNLDNYKIGNSIDEFMQWIMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0162 544 MSRKMFSCDFETTTKLDDCRVWAYGYMELGNLDNYKIGNSIDEFMQWIMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0163 545 MHKMSRKRFSCDFETTTKLDDCRVWAYGYMEVGNLDNYKIGNNIDEFMQWAMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0164 546 MSRKRFSCDFETTTKLDDCRVWAYGYMEVGNLDNYKIGNNIDEFMQWAMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0165 547 MSRKRFSCDFETTTKLDDCRVWAYGYMEVGNLDNYKIGNNIDEFMQWIMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0166 548 MSRKRFSCDFETTTKLDDCRVWAYGYMEVGNLDNYKIGNTIDEFMQWIMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0167 549 MSRKMFSCDFETTTKLDDCRVWAYGYMEVGNLDNYKIGNNIDEFMQWAMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0168 550 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0169 551 MHKMSRKRFSCDFETTTKLDDCRVWAYGYMEVGNLDNYKIGNNIDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0170 552 MHKMSRKRFSCDFETTTKLDDCRVWAYGYMEVGNLDNYKIGNNIDEFMQWAMEIQADLYFHDLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0171 553 MHKMSRKRFSCDFETTTKLDDCRVWAYGYMEVGNLDNYKIGNNIDEFMQWAMEIQADLYFHDLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0172 554 MHKMSRKRFSCDFETTTKLDDCRVWAYGYMEVGNLDNYKIGNNIDEFMQWAMEIQADLYFHDLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0173 555 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0174 556 MHKMSKKMFSCDFETTTKLDDCRVWAYGYMEVGNLDNYKIGNNIDEFMQWIMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0175 557 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFFHDLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKVPDIIKDLVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0176 558 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFFHDLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKVPDAIKDLVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0177 559 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFFHDLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKVPDAIKDLVHPKKLGYWEHESTFKRAKYLRQKTYVQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0178 560 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFFHDLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKVPDIIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDTKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0179 561 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFFHDLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKVPDAIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDGKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0180 562 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFFHDLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKVPDAIKDLVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDGKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0181 563 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFFHDLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYVQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIEITLTNVDVDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0182 564 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFFHDLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKLHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYVQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIEITLTNVDVDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0183 565 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFFHDLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKQHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYVQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIEITLTNVDVDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0184 566 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFFHDLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIELTVTNVDLDLFFEHYEILEIHYTYGYMFRGSCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKVPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0185 567 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFFHDLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIELTVTNVDLDLFFEHYEILEIHYTYGYMFRSSCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKVPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0186 568 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0187 569 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSAYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0188 570 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSAYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0189 571 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0190 572 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0191 573 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKVPDIIKDLVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0192 574 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKVPDAIKDLVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0193 575 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKVPDAIKDLVHPKKLGYWEHESTFKRAKYLRQKTYVQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0194 576 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKVPDIIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDTKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0195 577 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKVPDAIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDGKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0196 578 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKVPDAIKDLVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDGKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0197 579 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYVQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIEITLTNVDVDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0198 580 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKLHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYVQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIEITLTNVDVDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0199 581 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKQHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYVQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIEITLTNVDVDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0200 582 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIELTVTNVDLDLFFEHYEILEIHYTYGYMFRGSCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKVPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0201 583 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIELTVTNVDLDLFFEHYEILEIHYTYGYMFRSSCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKVPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0202 584 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKVPDIIKDLVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0203 585 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKVPDAIKDLVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0204 586 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0205 587 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDVNSMYPAMMKNKLLPYGEPVMFKGEYKKNVEYPLYIQQVRCFFELKKDKIPCIQIKGNARFGQNEYLSTSGDEYVDLYVTNVDWELIKKHYDIFEEEFIGGFMFKGFIGFFDEYIDRFMEIKNSPDSSAEQSLQAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0206 588 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKKNVEYPLYIQQVRCFFELKKDKIPCIQIKGNARFGQNEYLSTSGDEYVDLYVTNVDWELIKKHYDIFEEEFIGGFMFKGFIGFFDDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0207 589 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRPLPYGAPIVFQGKYEKDEQYPLYIQRIRFEFELKEGYIPTIQIKKNPFFKGNEYLKNSGVEPVELYLTNVDLELIQEHYELYNVEYIDGFKFREKTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0208 590 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0209 591 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKPNNDYPLYIQNIKVRFRLKEGYIPTIQVKQSSLFIQNEYLDSSVNKLGVDELIDLTLTNVDLELFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0210 592 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSAYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKEGYIPTIQIKRSRFYKGNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0211 593 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSAYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKEGYIPTIQIKRSRFYKGNEYLKSSGGELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0212 594 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSAYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKEGYIPTIQIKRSRFYKGNEYLKSSGGELIELTLTNVDLELMKEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0213 595 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSAYPAQMYVRLLPYGEPLFYEGEYKENIDHPLYIQNLKVRFRLKEGYIPTIQIKRSRFYKGNEYLKSSGGELIELTLTNVDLELMKEHYEILEIHYTYGYMFKATTGMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0214 596 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSAYPAQMYVRLLPYGEPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFKATTGMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0215 597 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSAYPAQMYVRLLPYGEPLFYEGEYKENIDHPLYIQNLKVRFRLKEGYIPTIQIKRSRFYKGNEYLKSSGGELIELTLTNVDLDLFFEHYEILEIHYTYGYMFKATTGMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0216 598 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKRSRLFIQNEYLESSVNELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0217 599 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKRSRLFKQNEYLESSVNELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0218 600 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKRSRLYKQNEYLESSVNELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0219 601 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKRSRFYKGNEYLESSVNELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0220 602 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKRSRLFKQNEYLESSVNELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0221 603 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGLPVPFSGEYEYDETHPLFIQHIKCGFELKDGHIPTIQIKKNFRFADNEYLHSSEGNILDLHVTNVDLALIKEHYTLYEEEYLQGYKFKQVTGLFKNYIDYWSDKKINAEDPAIRQMAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0222 604 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSAYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0223 605 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0224 606 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0225 607 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0226 608 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0227 609 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDVNSMYPAMMKNKLLPYGEPVMFKGEYKKNVEYPLYIQQVRCFFELKKDKIPCIQIKGNARFGQNEYLSTSGDEYVDLYVTNVDWELIKKHYDIFEEEFIGGFMFKGFIGFFDEYIDRFMEIKNSPDSSAEQSLQAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0228 610 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKRSRLFIQNEYLESSVNELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0229 611 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKRSRLFKQNEYLESSVNELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0230 612 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKRSRLYKQNEYLESSVNELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0231 613 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKRSRFYKGNEYLESSVNELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0232 614 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKRSRLFKQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0233 615 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKEGYIPTIQIKRSRFYKGNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0234 616 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKEGYIPTIQIKRSRFYKGNEYLKSSGGELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0235 617 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKEGYIPTIQIKRSRFYKGNEYLKSSGGELIELTLTNVDLELMKEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0236 618 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0237 619 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSAYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0238 620 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0239 621 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0240 622 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKEGYIPTIQIKRSRFYKGNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0241 623 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKEGYIPTIQIKRSRFYKGNEYLKSSGGELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0242 624 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKEGYIPTIQIKRSRFYKGNEYLKSSGGELIELTLTNVDLELMKEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0243 625 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKVPDIIKDLVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0244 626 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKVPDAIKDLVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0245 627 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKVPDAIKDLVHPKKLGYWEHESTFKRAKYLRQKTYVQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0246 628 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKVPDIIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDTKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0247 629 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVKNKLLPYGEPVMFKGEYKKNVEYPLYIQQVRCFFELKKDKIPCIQIKGNARFGQNEYLSTSGDEYVDLYVTNVDWELIKKHYDIFEEEFIGGFMFKGMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0248 630 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0249 631 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0250 632 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYSRLLPYGEPIVFEGKYVWDEDHPLHIQHLRCEFELKEGYIPCIQIKQSLFYKGNEYLKSSGGEIAELWLSNVDLELMKEHYELYNVEYISGLKFRATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0251 633 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0252 634 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKQSLFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0253 635 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKQSLFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0254 636 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIVNWLEKNGFKWSAEGLPNTYNTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKQSLFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0255 637 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLEKNGFKWSAEGLPNTYNTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKQSLFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0256 638 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKQSLFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0257 639 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKQSLFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0258 640 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKQSLFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKVPDAIKDLVHPKKLGYWEHESTFKRAKYLRQKTYVQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0259 641 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKQSLFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKVPDAIKDLVHPKKLGYWEHESTFKRAKYLRQKTYVQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0260 642 MKHMPRKRYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQIKQSLFYKGNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0261 643 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0262 644 MKHMPRKRYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0263 645 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0264 646 MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKVQADLYFHNLKFDGAFIVNWLEKNGFKWSAEGLPNTYNTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYSRLLPYGEPIVFEGKYVWDEDHPLHIQHLRCEFELKEGYIPCIQIKQSLFYKGNEYLKSSGGEIAELWLSNVDLELMKEHYELYNVEYISGLKFRATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKVPDAIKDLVHPKKLGYWEHESTFKRAKYLRQKTYVQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0265 647 MKHMPRKRYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIVNWLEKNGFKWSAEGLPNTYNTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYSRLLPYGEPIVFEGKYVWDEDHPLHIQHLRCEFELKEGYIPCIQIKQSLFYKGNEYLKSSGGEIAELWLSNVDLELMKEHYELYNVEYISGLKFRATTGLFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKVPDAIKDLVHPKKLGYWEHESTFKRAKYLRQKTYVQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0266 648 MKHMPRKRYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0267 649 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0268 650 MKHMPRKRYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIVNWLEKNGFKWSAEGLPNTYNTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKVPDAIKDLVHPKKLGYWEHESTFKRAKYLRQKTYVQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0269 651 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLENSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0270 652 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0271 653 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLENSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0272 654 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLENSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0273 655 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0274 656 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0275 657 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICVGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0276 658 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0277 659 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKQHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYVQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0278 660 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIEITLTNVDVDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0279 661 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYVQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIEITLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0280 662 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKQHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDVDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0281 663 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTVTNVDLDLFFEHYEILEIHYTYGYMFRGSCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0282 664 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTVTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKVPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0283 665 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRGSCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKVPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0284 666 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTVTNVDLDLFFEHYEILEIHYTYGYMFRGSCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKVPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0285 667 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVDGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0286 668 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKLSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0287 669 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYVQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLENSVNKLGVDELIEITLTNVDVDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0288 670 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0289 671 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0290 672 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0291 673 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEKNGFKWSAEGLPNTYNTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0292 674 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0293 675 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIVNWLEKNGFKWSAEGLPNTYNTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0294 676 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIVNWLEKNGFKWSAEGLPNTYNTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0295 677 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0296 678 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0297 679 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPTIQVKQNSLFIQNEYLENSVNKLGVDELIDLTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0298 680 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIVNWLEKNGFKWSAEGLPNTYNTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0299 681 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0300 682 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0301 683 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0302 684 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0303 685 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0304 686 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0305 687 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0306 688 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHDLKFDGAFIINWLFRNGFKWCKDAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0307 689 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0308 690 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHDLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPTIQVKQNSLFIQNEYLENSVNKLGVDELIDLTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGVVLVDETFTIK
C0309 691 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0310 692 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0311 693 MKHMPRKRYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0312 694 MKHMPRKRYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIVNWLEKNGFKWSAEGLPNTYNTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0313 695 MKHMPRKRYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKVPDAIKDLVHPKKLGYWEHESTFKRAKYLRQKTYVQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0314 696 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKVPDAIKDLVHPKKLGYWEHESTFKRAKYLRQKTYVQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0315 697 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKVPDAIKDLVHPKKLGYWEHESTFKRAKYLRQKTYVQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0316 698 MKHMPRKRYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKVPDAIKDLVHPKKLGYWEHESTFKRAKYLRQKTYVQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0317 699 MKHMPRKRYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIVNWLEKNGFKWSAEGLPNTYNTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKVPDAIKDLVHPKKLGYWEHESTFKRAKYLRQKTYVQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0318 700 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKVPDAIKDLVHPKKLGYWEHESTFKRAKYLRQKTYVQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0319 701 MKHMPRKRYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKVPDAIKDLVHPKKLGYWEHESTFKRAKYLRQKTYVQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0320 702 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0321 703 MKHMPRKRYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0322 704 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0323 705 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0324 706 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0325 707 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0326 708 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0327 709 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0328 710 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0329 711 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0330 712 MKHMPRKRYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0331 713 MKHMPRKRYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0332 714 MKHMPRKRYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0333 715 MKHMPRKRYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0334 716 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0335 717 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0336 718 MKHMPRKRYSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0337 719 MKHMSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0338 720 MKHMPRKRYSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKVPDAIKDLVHPKKLGYWEHESTFKRAKYLRQKTYVQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0339 721 MKHMPRKRYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0340 722 MKHMPRKRYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSHYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0341 723 MKHMPRKRYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLAVFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0342 724 MKHMPRKRYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0343 725 MKHMPRKRYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLAVFVTAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0344 726 MKHMSRKRYSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0345 727 MPRKRYSCDFETTTKVEDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0346 728 MSRKRFSCDFETTTKLDDCRVWAYGYMNIEDHSEYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0347 729 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0348 730 MSRKRFSCDFETTTKLDDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0349 731 MPRKRYSCDFETTTKVEDCRVWAYGYMEIGNLDNYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0350 732 MPRKRYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0351 733 MKHMPRKRYSCDFETTTKLDDCRVWAYGYMEIGNLSEYKIGNSLDEFMQWAMKIQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0352 734 MKHMPRKRYSCDFETTTKLDDCRVWAYGYMEIGNHSEYKIGNSLDEFMQWAMKIQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0352B 735 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0353 736 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
C0354 737 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0355 738 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
C0356 739 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
C0357 740 MKHMPRKRYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWALKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
C0358 741 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0359 742 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFGTNPDITGKVPYMGEDGIVRLTLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMPDRIKELVTFDNFEVGFSSYGKLLPKRTQGGVVLVDTMFTIK
C0360 743 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKEGYIPTIQIKQSLFYKGNEYLKSSGGELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0361 744 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0362 745 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKRSRLFIQNEYLESSVNELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0363 746 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKEGYIPTIQIKRSRFYKGNEYLKSSGGELIELTLTNVDLELMKEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0364 747 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSAYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0365 748 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSHYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0366 749 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0367 750 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDVNSAYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWFYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0368 751 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDVNSAYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0369 752 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0370 753 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIINWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICLGYKGKRKIHTVIYDSLKKLPFPVEKIAKDFKLTVKKGDIDIHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDANSAYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWGRYTTITAAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVKGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0371 754 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0372 755 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTLISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0373 756 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTLISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0374 757 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0375 758 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKDDGSLGFRVGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0376 759 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKDDGILGFRVGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0377 760 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKDDGALGFRVGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0378 761 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKEDGALGFRVGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0379 762 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKEDGIVRLTLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0380 763 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKEDGIVGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0381 764 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKDDGIVGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0382 765 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKDDGIVGFRVGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0383 766 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKDDGAVGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0384 767 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGIVGFRVGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0385 768 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDRIKEEVTFDNFKVGFSRKMKPKPKQVPGGVVLVDSVFTIK
C0386 769 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDRIKEEVTFDNFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0387 770 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDRIKEEVTFDNFKVGFSRKMKPKPVQTPGGVVLVDSVFTIK
C0388 771 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDRIKEEVTFENFKVGFSRKMKPKPVQTPGGVVLVDSVFTIK
C0389 772 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDTIKEEVTFDNFKVGFSRKMKPKPKQVPGGVVLVDSVFTIK
C0390 773 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDTIKEEVTFDNFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0391 774 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDTIKEEVTFDNFKVGFSRKMKPKPVQTPGGVVLVDSVFTIK
C0392 775 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPIGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDILTTKKFKKVFPTLSLGLDKEIRKAYRGGFTWVNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0393 776 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDILTTKKFKKVFPTLSLGLDKEIRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0394 777 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTLISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDILTTKKFKKVFPTLSLGLDKEIRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0395 778 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTLISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYQGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQNSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0396 779 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTLISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKDDGALGFRVGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0397 780 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTLISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGIVGFRVGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0398 781 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTLISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGIVGFRVGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDRIKEEVTFDNFKVGFSRKMKPKPKQVPGGVVLVDSVFTIK
C0399 782 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTLISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGIVGFRVGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDRIKEEVTFDNFKVGFSRKMKPKPVQTPGGVVLVDSVFTIK
C0400 783 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTLISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDILTTKKFKKVFPTLSLGLDKEIRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGIVGFRVGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDRIKEEVTFDNFKVGFSRKMKPKPVQTPGGVVLVDSVFTIK
C0401 784 MSRKRFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWAMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTLISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDILTTKKFKKVFPTLSLGLDKEIRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGIVGFRVGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDRIKEEVTFDNFKVGFSRKMKPKPVQTPGGVVLVDSVFTIK
C0402 785 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTLISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPIGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDILTTKKFKKVFPTLSLGLDKEIRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDHPLYIQNLKVRFRLKERHIPCIQVKQSSLFIQNEYLESSVNKLGVDELIELTLTNVDLDLFFEHYEILEIHYTYGYMFRASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGIVGFRVGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDRIKEEVTFDNFKVGFSRKMKPKPVQTPGGVVLVDSVFTIK
C0403 786 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKDDGSLGFRVGDEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0404 787 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKDDGSLGFRVGDEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDTIKEEVTFDNFAVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0405 788 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLAVFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0406 789 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKKLTTIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0407 790 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKQRTIFYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0408 791 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKQRTIFYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0409 792 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKNHVVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0410 793 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKNHVVFYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0411 794 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKGTTQIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0412 795 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKFRVEIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0413 796 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKFRVEFYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDRFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0414 797 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNDKYKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0415 798 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNPKYKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0416 799 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNPKFKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0417 800 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLNPRYKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0418 801 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLDPKYKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
C0419 802 MSRKMFSCDFETTTKLDDCRVWAYGYMEIGNLDNYKIGNSLDEFMQWVMEIQADLYFHNLKFDGAFIVNWLFKNGFKWCKEAKEERTFSTIISRMGQWYMIDICIGYKGKRKIHTVIYDSLKKLPFPVKKIAQDFKLTVKKGDIDYHKERPVGYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKDFKDIITTKKFKKVFPTLSLGLDKEVRKAYRGGFTWLDPRYKGKEIGEGMVFDINSAYPAQMYVRPLPYGTPLFYEGEYKENIDYPLYIQNIKVRFRLKERHIPTIQVKQSSLFIQNEYLESSVNKLGVDELIDLTLTNVDLDLFFEHYDILEIHYTYGYMFKASCDMFKDFIDKWTYIKTTSYGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPLASFVTAWGRYTTITTAQACYDRIIYCDTDSIHLTGTKIPDVIKDIVHPKKLGYWEHESTFKRAKYLRQKTYIQDIYMKRVRGYLVQGSPDDYTDIKFSVKCAGMTDKIKEEVTFENFKVGFSRKMKPKPVQVPGGVVLVDSVFTIK
表5.嵌合聚合酶-經取代部分
名稱 大多數序列 經取代序列來源 所取代之區域/ 部分
C001 Q001 M2Y (SEQ ID NO: 6) 外切核酸酶,TPR1
C002 Q001 M2Y (SEQ ID NO: 6) 外切核酸酶,TPR1
C003 Q001 M2Y (SEQ ID NO: 6) 外切核酸酶,TPR1
C010 Q001 屎腸球菌(SEQ ID NO: 2) 外切核酸酶
C011 Q001 屎腸球菌(SEQ ID NO: 2) 外切核酸酶
C012 Q001 屎腸球菌(SEQ ID NO: 2) TPR1
C013 Q001 屎腸球菌(SEQ ID NO: 2) TPR1
C014 Q001 屎腸球菌(SEQ ID NO: 2) 外切核酸酶,TPR1
C015 Q001 屎腸球菌(SEQ ID NO: 5) 外切核酸酶,TPR1
C016 Q002 M2Y (SEQ ID NO: 6) 外切核酸酶
C017 Q001 M2Y (SEQ ID NO: 6) 外切核酸酶
C018 Q001 M2Y (SEQ ID NO: 6) TPR1
C019 Q001 M2Y (SEQ ID NO: 6) 外切核酸酶,TPR1
C020 Q001 銅綠蠅(SEQ ID NO: 7) 外切核酸酶
C021 Q001 銅綠蠅(SEQ ID NO: 7) TPR1
C022 Q001 銅綠蠅(SEQ ID NO: 7) 外切核酸酶,TPR1
C023 Q001 屎腸球菌(SEQ ID NO: 2) 外切核酸酶
C024 Q001 屎腸球菌(SEQ ID NO: 2) 外切核酸酶
C029 C017 屎腸球菌(SEQ ID NO: 2) 經取代自屎腸球菌之53個殘基之段
C030 C013 屎腸球菌(SEQ ID NO: 2) 經取代自屎腸球菌之56個殘基之段
C031 C013 M2Y (SEQ ID NO: 6) 經取代自M2Y之56個殘基之段
C032 C013 放線菌噬菌體AV-1 (SEQ ID NO: 11) 經取代自放線菌噬菌體AV-1之75個殘基之段
C033 C013 埃格特菌屬(SEQ ID NO: 14) 經取代自埃格特菌屬之58個殘基之段
C034 Q001 M2Y (SEQ ID NO: 6),屎腸球菌(SEQ ID NO: 2) 來自M2Y之外切核酸酶、來自屎腸球菌之TPR1
C035 Q001 屎腸球菌(SEQ ID NO: 2) TPR1,手指型,拇指型
C036 Q001 屎腸球菌(SEQ ID NO: 2) TPR1,TPR2,拇指型
C037 Q001 放線菌噬菌體AV-1 (SEQ ID NO: 11) TPR1
C038 Q001 埃格特菌屬(SEQ ID NO: 14) TPR1
C039 C013 M2Y (SEQ ID NO: 6) 經取代自M2Y之殘基1-85
C040 C013 M2Y (SEQ ID NO: 6) 經取代自M2Y之殘基1-85、121-180
C041 C013 M2Y (SEQ ID NO: 6) 經取代自M2Y之殘基1-56
C042 C013 M2Y (SEQ ID NO: 6) 經取代自M2Y之殘基1-56
C043 C031 Q001 掌型
C044 C031 Q001 掌型
C045 C031 Q001 掌型
C046 C031 Q001 掌型
C047 C031 Q001 掌型
C048 C031 Q001 掌型
C049 C031 Q001 掌型
C050 C031 Q001 掌型
C051 C032 Q001 掌型
C052 C032 Q001 掌型
C053 C032 Q001 掌型
C054 C032 Q001 掌型
C055 C032 Q001 掌型
C056 C032 Q001 掌型
C057 C032 Q001 掌型
C058 C032 Q001 掌型
C059 C033 屎腸球菌(SEQ ID NO: 2) TPR2,拇指型
C060 C033 屎腸球菌(SEQ ID NO: 2) TPR2
C061 C033 屎腸球菌(SEQ ID NO: 2) 拇指型
C062 C034 屎腸球菌(SEQ ID NO: 2) TPR2,拇指型
C063 C034 屎腸球菌(SEQ ID NO: 2) TPR2
C064 C034 屎腸球菌(SEQ ID NO: 2) 拇指型
C0190 Q035 M2Y (SEQ ID NO: 6),屎腸球菌(SEQ ID NO: 2) 來自經取代替代了260-359之屎腸球菌之殘基271-375;來自經取代替代了1-54之M2Y之殘基1-51;來自經取代替代了75-91之屎腸球菌之殘基72-89;來自經取代替代了429-433之屎腸球菌之殘基445-449
C0256 Q035 M2Y (SEQ ID NO: 6),屎腸球菌(SEQ ID NO: 2) 來自經取代替代了1-54之M2Y之殘基1-51;來自經取代替代了75-91之屎腸球菌之殘基72-89
C0267 Q035 M2Y (SEQ ID NO: 6),屎腸球菌(SEQ ID NO: 2) 來自經取代替代了260-359之屎腸球菌之殘基271-375;來自經取代替代了1-54之M2Y之殘基1-51;來自經取代替代了429-433之屎腸球菌之殘基445-449
C0320 Q035 M2Y (SEQ ID NO: 6),屎腸球菌(SEQ ID NO: 2) 來自經取代替代了260-359之屎腸球菌之殘基271-375;來自經取代替代了1-54之M2Y之殘基1-51;來自經取代替代了75-91之屎腸球菌之殘基72-89;來自經取代替代了429-433之屎腸球菌之殘基445-449
C0334 Q035 M2Y (SEQ ID NO: 6),屎腸球菌(SEQ ID NO: 2) 來自經取代替代了260-359之屎腸球菌之殘基271-375;來自經取代替代了1-54之M2Y之殘基1-51
C0364 Q035 M2Y (SEQ ID NO: 6),屎腸球菌(SEQ ID NO: 2) 來自經取代替代了260-359之屎腸球菌之殘基271-375;來自經取代替代了1-54之M2Y之殘基1-51;來自經取代替代了75-91之屎腸球菌之殘基72-89;來自經取代替代了429-433之屎腸球菌之殘基445-449
表6.嵌合聚合酶-定點突變體
名稱 大多數序列 描述
C004 C017 L259I、E264D、E269D、E276D、D277E、E293D
C005 C017 L259I、E264D、E269D、E276D、D277E、E288D、E293D、E319D、I320L、A321V、D322E
C006 C017 L259I、E264D、E269D、E276D、D277E、E288D、E293D、E319D、I320L、A321V、D322E L325I、N327Q、L330I、E331D、D338E、I345L、L348I、K351R、L356I
C007 C017 K15R、I37L、Q52N、I67L、K77R
C008 C017 K15R、I37L、Q52N、I67L、K77R、L259I、E264D、E269D、E276D、D277E、E288D、E293D、E319D、I320L、A321V、D322E L325I、N327Q、L330I、E331D、D338E、I345L、L348I、K351R、L356I
C009 C006 L259I、E264D、E269D、E276D、D277E、E288D、E293D、I320L、A321V、D322E、W324Y、L325V、S326T、V328I、E331D、M333I、D338E、I345L、K351R
C025 C017 I464V、D466E、V467A、K469E、D470H、I471L、P474S、K487Q、Y491F、L492I
C026 C017 I464V、D466E、V467A、K469E、D470H、I471L、K487Q、Y491F、L492I
C027 C017 M503V、R505K、K507R、G513C、D517E、Y518A、D520T、I521T
C028 C017 464-497區域及498-554區域中之突變
表7.例示性修飾組合-對應於SEQ ID NO: 2之位置.
組合編號 描述
1 Y148I、A484E
2 Y148I、V250A、L253H
3 Y148I、V250A、L253A
4 Y148I、V250A、L253H、E375Y
5 Y148I、V250A、L253H、E375Y、A484E
6 S267A、I384T、N388T A396Q、N397L G400L、K500E、Q506K、S493P (對應於SEQ ID NO: 2之位置);Y148I、V250A、L253H、E375Y (對應於SEQ ID NO: 1之位置)
7 S267A、A396Q、G400L、K500E (對應於SEQ ID NO: 2之位置);Y148I、V250A、L253H、E375Y (對應於SEQ ID NO: 1之位置)
8 具有環之Y148I (對應於SEQ ID NO: 1之位置)
9 L264H、K500E、N59D
10 L264H、V261A、K500E、N59D
11 L264H、K500E、I384F、N59D
12 L264H、V261A、K500E、I384F、N59D
13 L264A、K500E、N59D
14 L264A、V261I、K500E、N59D
15 L264A、K500E、I384F、N59D
16 L264A、V261I、K500E、I384F、N59D
17 I384F、N59D
18 I384F、E391Y、N59D
19 I384F、E391Y、L264H、N59D
20 I384F、E391Y、L264A、N59D
21 I384F、E391Y、L264H、V261A、N59D
22 I384F、E391Y、L264A、V261I、N59D
23 K4R、N59D
24 D232K、N59D
25 Q513D、N59D
26 R308G、N59D
27 E60L、N59D
28 D341T、N59D
29 D337G、N59D
30 S22A、N59D
31 E85P、N59D
32 T211A、N59D
33 N106G、N59D
34 Q122V、N59D
35 T479V、N59D
36 S493P、N59D
37 E139K、E142K、E391Y、D521K、E482K、D492H、N59D
38 I148K、E391Y、E523K、E482K、D492H、N59D
39 I148K、E391Y、E523K、E482K、D492H、S22A、D341T、D337G、L264H、N59D
40 K4R、Q513D、D232K、E139K、E142K、E391Y、D521K、E482K、D492H、L264H、K500E、V261A、I384F、N59D
41 K4R、Q513D、D232K、E139K、E142K、E391Y、D521K、E482K、D492H、R308G、E60L、L264H、K500E、I384F、N59D
42 K4R、Q513D、E139Q、E142K、I148K、D167P、E391Y、E482K、D492H、D521K、E523K、R308G、E60L、S22A、E85P、T211A、N106G、T479V、S493P、Q122V、L264A、K500E、V261I、I384F、N59D
43 L264H、V261A、K500E、R308G
44 L264H、V261A、K500E、E391Y、R308G
45 L264H、V261A、K500E、I384F、R308G
46 L264H、V261A、K500E、I384F、E391Y、R308G
47 L264H、V261A、K500E、E391Y、R308G、I148K、E482K、D492H
48 L264H、V261A、K500E、E391Y、R308G、I148K、E523K、D521K、E482K、D492H
49 L264H、V261A、K500E、I384F、E391Y、R308G、I148K、E482K、D492H
50 L264H、V261A、K500E、I384F、E391Y、R308G、I148K、E523K、D521K、E482K、D492H
51 L264H、V261A、K500E、E391Y、R308G、S22A、D341T、D337G、I148K、E482K、D492H
52 L264H、V261A、K500E、E391Y、R308G、S22A、D341T、D337G、I148K、E523K、D521K、E482K、D492H
53 L264H、V261A、K500E、I384F、E391Y、R308G、S22A、D341T、D337G、I148K、E482K、D492H
54 L264H、V261A、K500E、I384F、E391Y、R308G、S22A、D341T、D337G、I148K、E523K、D521K、E482K、D492H
55 L264H、V261A、K500E、R308G、I148K、E482K、D492H
56 L264H、V261A、K500E、R308G、I148K、E523K、D521K、E482K、D492H
57 L264H、V261A、K500E、I384F、R308G、I148K、E482K、D492H
58 L264H、V261A、K500E、I384F、R308G、I148K、E523K、D521K、E482K、D492H
59 L264H、V261A、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、E142K、E537K、D171K、D521K
60 L264H、V261A、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、E139K、D189K、E537K、D171K
61 L264H、V261A、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、E139K、E537K、D171K、D521K
62 L264H、V261A、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
63 L264H、V261A、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、D189K、E537K、D167P、D171K
64 L264H、V261A、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、E142K、E537K、D167P、D521K
65 L264H、V261A、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、D171K、D521K
66 L264H、V261A、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、E139K、D167P、D171K、D521K
67 L264H、V261A、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D167P
68 L264H、V261A、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、D189K、D167P、D171K、D521K
69 具有來自phi29之TRP1的EMF37
70 組合62+P136T
71 組合62+L320M
72 組合62+E338K
73 組合62+E523V
74 組合65+P136T
75 組合65+L320M
76 組合65+E338K
77 組合65+E523V
78 組合62+雙生物素
79 組合62+雙生物素-N端His
80 組合79+L264H、V261、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
81 組合79+L264H、V261I、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
82 組合79+L264A、V261A、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
83 組合79+L264A、V261V、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
84 組合79+L264A、V261I、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
85 組合79+L264M、V261A、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
86 組合79+L264M、V261V、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
87 組合79+L264M、V261I、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
88 組合79+L264、V261A、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
89 組合79+L264、V261V、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
90 組合79+L264、V261I、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
91 組合62+環B103、N端his
92 組合62+環嵌合體、N端His
93 組合79+L264H、V261A、K500E、R308G、S22A、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K、
94 組合79+L264H、V261A、K500E、R308G、D341T、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
95 組合79+L264H、V261A、K500E、R308G、D337G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
96 組合79+L264H、V261A、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
97 組合79+L264H、V261A、K500E、R308G、E85P、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
98 組合79+L264H、V261A、K500E、R308G、S22A、D341T、D337G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
99 組合79+L264H、V261A、K500、R308G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
100 組合79+L264H、V261A、K500E、R308、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
101 組合79+L264H、V261A、K500E、R308G、I148、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
102 組合79+L264H、V261A、K500E、R308G、I148K、E391Y、E523K、E482、D492H、E142K、D189K、E537K、D521K
103 組合79+L264H、V261A、K500E、R308G、I148K、E391Y、E523K、E482K、D492、E142K、D189K、E537K、D521K
104 組合79+L264H、V261A、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521
105 組合79+L264H、V261A、K500E、R308G、I148K、E391W、E523K、E482K、D492H、E142K、D189K、E537K、D521K
106 組合79+L264H、V261A、K500E、R308G、I148K、E391Y、E523Y、E482K、D492H、E142K、D189K、E537K、D521K
107 組合79+L264H、V261A、K500E、R308G、I148K、E391W、E523Y、E482K、D492H、E142K、D189K、E537K、D521K
108 組合79+I384F、L264H、V261A、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
109 組合79+I384S、L264H、V261A、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
110 L264H、V261、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
111 L264H、V261I、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
112 L264A、V261A、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
113 L264A、V261V、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
114 L264A、V261I、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
115 L264M、V261A、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
116 L264M、V261V、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
117 L264M、V261I、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
118 L264、V261A、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
119 L264、V261V、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
120 L264、V261I、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
121 L264H、V261A、K500E、R308G、S22A、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K、
122 L264H、V261A、K500E、R308G、D341T、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
123 L264H、V261A、K500E、R308G、D337G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
124 L264H、V261A、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
125 L264H、V261A、K500E、R308G、E85P、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
126 L264H、V261A、K500E、R308G、S22A、D341T、D337G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
127 L264H、V261A、K500、R308G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
128 L264H、V261A、K500E、R308、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
129 L264H、V261A、K500E、R308G、I148、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
130 L264H、V261A、K500E、R308G、I148K、E391Y、E523K、E482、D492H、E142K、D189K、E537K、D521K
131 L264H、V261A、K500E、R308G、I148K、E391Y、E523K、E482K、D492、E142K、D189K、E537K、D521K
132 L264H、V261A、K500E、R308G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521
133 L264H、V261、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
134 L264H、V261I、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
135 L264A、V261A、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
136 L264A、V261V、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
137 L264A、V261I、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
138 L264M、V261A、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
139 L264M、V261V、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
140 L264M、V261I、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
141 L264、V261A、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
142 L264、V261V、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
143 L264、V261I、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
144 L264H、V261A、K500E、R308G、E60L、S22A、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K、
145 L264H、V261A、K500E、R308G、E60L、D341T、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
146 L264H、V261A、K500E、R308G、E60L、D337G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
147 L264H、V261A、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
148 L264H、V261A、K500E、R308G、E60L、E85P、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
149 K4R、L264H、V261A、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
150 Q513D、L264H、V261A、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
151 D232K、L264H、V261A、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
152 L264H、V261A、E60L、K500、R308G、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
153 L264H、V261A、K500E、R308、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
154 L264H、V261A、K500E、R308G、E60L、I148、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
155 L264H、V261A、K500E、R308G、E60L、I148K、E391Y、E523K、E482、D492H、E142K、D189K、E537K、D521K
156 L264H、V261A、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492、E142K、D189K、E537K、D521K
157 L264H、V261A、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521
158 L264H、V261A、K500E、R308G、E60L、I148K、E391W、E523K、E482K、D492H、E142K、D189K、E537K、D521K
159 L264H、V261A、K500E、R308G、E60L、I148K、E391Y、E523Y、E482K、D492H、E142K、D189K、E537K、D521K
160 L264H、V261A、K500E、R308G、E60L、I148K、E391W、E523Y、E482K、D492H、E142K、D189K、E537K、D521K
161 I384F、L264H、V261A、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
162 I384S、L264H、V261A、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K
163 L264H、V261A、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K+T568D、M569T
164 L264H、V261A、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K+T568D、M569V
165 L264H、V261A、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K+P556A
166 L264H、V261A、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K+E65S
167 L264H、V261A、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K+E436R
168 L264H、V261A、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K+W452Y
169 L264H、V261A、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K+Y455W
170 L264H、V261A、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K+W452Y、Y455W
171 L264H、V261A、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K+L437Y
172 L264H、V261A、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K+L437E
173 L264H、V261A、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K+S503A
174 L264H、V261A、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K+G453A
175 L264H、V261A、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K+Y133L
176 L264H、V261A、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K+S267A
177 L264H、V261A、K500E、R308G、E60L、I148K、E391Y、E523K、E482K、D492H、E142K、D189K、E537K、D521K+L555K
178 H264A、A261I、K500E、R308G、E60L、I148K、E391W、K523Y、E482K、D492H、E142K、D189K、E537K、D521K
179 組合160+Y133L
180 組合160+S267A
181 組合160+H492D
182 組合160+A261V
183 組合160+W452Y、Y455W
184 組合160+Y133L、S267A
185 組合160+Y133L、H492D
186 組合160+Y133L、A261V
187 組合160+Y133L、W452Y、Y455W
188 組合160+S267A、H492D
189 組合160+S267A、A261V
190 組合160+S267A、W452Y、Y455W
191 組合160+H492D、A261V
192 組合160+H492D、W452Y、Y455W
193 組合160+A261V、W452Y、Y455W
194 組合160+Y133L、S267A、H492D
195 組合160+Y133L、S267A、A261V
196 組合160+Y133L、S267A、W452Y、Y455W
197 組合160+Y133L、H492D、A261V
198 組合160+Y133L、H492D、W452Y、Y455W
199 組合160+Y133L、A261V、W452Y、Y455W
200 組合160+S267A、H492D、A261V
201 組合160+S267A、H492D、W452Y、Y455W
202 組合160+S267A、A261V、W452Y、Y455W
203 組合160+H492D、A261V、W452Y、Y455W
204 組合160+Y133L、S267A、H492D、A261V
205 組合160+Y133L、S267A、H492D、W452Y、Y455W
206 組合160+Y133L、S267A、A261V、W452Y、Y455W
207 組合160+Y133L、H492D、A261V、W452Y、Y455W
208 組合160+S267A、H492D、A261V、W452Y、Y455W
209 組合160+Y133L、S267A、H492D、A261V、W452Y、Y455W
210 組合160+A261L
211 組合160+H492K
212 組合160+H492A
213 組合160+H492S
214 組合160+G308R
215 組合160+I384F
216 組合160+I384S
217 組合160+H264A、A261L
218 組合160+H264A、A261V
219 組合178+Y133L
220 組合178+S267A
221 組合178+H492D
222 組合178+W452Y、Y455W
223 組合178+Y133L、S267A
224 組合178+Y133L、H492D
225 組合178+Y133L、W452Y、Y455W
226 組合178+S267A、H492D
227 組合178+S267A、W452Y、Y455W
228 組合178+H492D、W452Y、Y455W
229 組合178+Y133L、S267A、H492D
230 組合178+Y133L、S267A、W452Y、Y455W
231 組合178+Y133L、H492D、W452Y、Y455W
232 組合178+S267A、H492D、W452Y、Y455W
233 組合178+Y133L、S267A、H492D、W452Y、Y455W
234 組合178+I261L
235 組合178+H492K
236 組合178+H492A
237 組合178+H492S
238 組合178+G308R
239 組合178+I384F
240 組合178+I384S
241 組合178+I261V
242 組合160+D425N
243 組合160+R429G
244 組合160+D425N、R429G
245 組合160+M95T
246 組合160+R534K
247 組合160+K142Q
248 組合160+N145K
249 組合160+E139K
250 組合160+E139Q
251 組合160+Q206R
252 組合160+Q206K
253 組合160+N467R
254 組合160+Q323G
255 組合160+D414V
256 組合160+Q317R
257 組合160+S319R
258 組合160+I322K
259 組合160+Q323G
260 組合160+Q317R、S319R、I322K、Q323G
261 組合160+V443T、T450A、W452Y、Y455W
262 組合160+V443T、L445M、A446G、S447V、V449I
263 組合160+E545K
264 組合160+F465Y
265 組合160+Y523W
266 組合160+K189R
267 組合160+K142R
268 組合160+K495R
269 組合160+E385Y
270 組合160+D374G
271 組合160+D533A
272 組合160+K521R
II. 包含經修飾重組酶之組合物及套組 在一些態樣中,本發明係關於包含本文所描述之經修飾聚合酶之組合物。在一些實施例中,組合物包含複數個經修飾聚合酶。在一些實施例中,組合物進一步包含鹽及/或緩衝劑。
在一些態樣中,本發明係關於包含本文所述之經修飾聚合酶之套組。在一些實施例中,套組包含複數個經修飾聚合酶。套組可視情況提供額外組分(諸如緩衝劑)及說明性資訊。通常,套組包含容器及在容器上或與容器相關聯之標籤或包裝插頁。在一些實施例中,本發明提供包含上文所描述之套組之內含物的物品。適合的包裝包括但不限於小瓶、瓶子、廣口瓶、可撓性包裝以及類似物。在一些實施例中,該套組進一步包含容器、鹽及/或緩衝劑。
III. 產生經修飾重組酶之方法 在一些態樣中,本發明係關於以重組方式產生本文所述之經修飾聚合酶之方法。在一些實施例中,為表現本發明之聚合酶,將編碼該聚合酶之DNA插入至一或多個表現載體中使得經編碼聚合酶可操作地連接於轉錄及轉譯控制序列(參見,例如美國專利第6,914,128號,其內容以引用之方式併入本文中)。在此背景下,術語「可操作地連接」意指編碼聚合酶之序列連接至載體中使得載體中之轉錄及轉譯控制序列發揮其調節聚合酶之轉錄及轉譯的預期功能。選擇與所用表現宿主細胞相容的表現載體及表現控制序列。將聚合酶編碼序列藉由標準方法(例如,聚合酶編碼序列上之互補限制位點與載體之連接或當無限制位點存在時之鈍端連接)插入至表現載體中。
為表現經修飾聚合酶,可以將編碼該經修飾聚合酶之表現載體藉由標準技術轉染至宿主細胞中。術語「轉染」之各種形式意欲涵蓋常用於將外源DNA引入至原核或真核宿主細胞中之各種技術,例如電穿孔、磷酸鈣沈澱、DEAE-聚葡萄糖轉染及類似技術。用於表現本發明之聚合酶之適合宿主細胞包括原核生物、酵母或更高級真核生物細胞。
用於此目的之適合原核生物包括真細菌,諸如革蘭氏陰性或革蘭氏陽性生物體,例如腸內菌科(Enterobacteriaceae ),諸如埃希氏桿菌屬(Escherichia ),例如大腸桿菌,腸桿菌屬(Enterobacter )、歐文菌屬(Erwinia )、克雷伯氏菌屬(Klebsiella )、變形桿菌屬(Proteus )、沙門氏菌屬(Salmonella ),例如鼠傷寒沙門桿菌(Salmonella typhimurium ),沙雷菌屬(Serratia ),例如黏質沙雷氏菌(Serratia marcescans ),及志賀桿菌屬(Shigella ),以及桿菌(Bacilli ),諸如枯草芽孢桿菌(B. subtilis )及地衣芽孢桿菌(B. licheniformis ),假單胞菌屬(Pseudomonas ),諸如綠膿桿菌(P. aeruginosa ),及鏈黴菌(Streptomyces )。除原核生物之外,諸如絲狀真菌或酵母之真核微生物係用於編碼載體之多肽的適合選殖或表現宿主。在低級真核宿主微生物中,最常用的係釀酒酵母(Saccharomyces cerevisiae )或普通烘焙酵母。然而,在本文中若干其他屬、物種及菌株通常係可獲得的且有用的,諸如粟酒裂殖酵母(Schizosaccharomyces pombe );克魯維酵母(Kluyveromyces )宿主諸如,例如,乳酸克魯維酵母(K. lactis )、脆壁克魯維酵母(K. fragilis )、保加利亞克魯維酵母(K. bulgaricus )、魏氏克魯維酵母(K. wickeramii )、沃特克魯維酵母(K. waltii )、果蠅克魯維酵母(K. drosophilarum )、耐熱克魯維酵母(K. thermotolerans )及馬克斯克魯維酵母(K. marxianus );巴斯德畢赤酵母(Pichia pastoris );假絲酵母(Candida );瑞氏木黴菌(Trichoderma reesia );粗厚神經胞子菌(Neurospora crassa );施氏酵母(Schwanniomyces )諸如西方施氏酵母(Schwanniomyces occidentalis );及絲狀真菌,諸如紅黴屬(Neurospora )、青黴菌屬(Penicillium )、彎頸黴屬(Tolypocladium )及麴菌屬(Aspergillus )宿主諸如,構巢麴菌(A. nidulans )及黑麴菌(A. niger )。
在一些實施例中,宿主細胞經用於產生聚合酶的上述表現或選殖載體轉型,且在適於誘導啟動子、選擇轉型體或擴增編碼所需序列的基因的經調節之習知營養物培養基中培養。用於產生聚合酶之宿主細胞可以在各種培養基中培養。市售培養基,諸Ham's F10™ (Sigma)、Minimal Essential Medium™ (MEM) (Sigma)、RPMI-1640 (Sigma)及Dulbecco's Modified Eagle's Medium™ (DMEM) (Sigma)適合於培養宿主細胞。培養條件(諸如溫度、pH及類似條件)為先前用於經選擇用於表現之宿主細胞之培養條件,且對於一般熟習此項技術者而言將顯而易見。
在一些實施例中,聚合酶變異體可以在周質空間中胞內產生或直接分泌於細胞培養基中。在其中聚合酶變異體胞內產生之實施例中,宿主細胞或溶解細胞顆粒碎片(例如由均質化產生)可以藉由各種手段移除,包括但不限於藉由離心或超過濾。其中聚合酶分泌於培養基中之情況下,來自此類表現系統之上清液可以首先使用可商購的蛋白質濃縮過濾器來濃縮,隨後可將其進行一或多個其他純化技術,包括但不限於:親和層析,包括蛋白質親和層析;離子交換層析,諸如陰離子或陽離子交換層析;及疏水相互作用層析。
在一些實施例中,經修飾聚合酶包含一或多個非天然胺基酸取代。如本文所用,「非天然胺基酸」係指除了以下二十種基因編碼的α胺基酸之外的任何胺基酸、經修飾胺基酸或胺基酸類似物:丙胺酸、精胺酸、天冬醯胺、天冬胺酸、半胱胺酸、麩醯胺酸、麩胺酸、甘胺酸、組胺酸、異白胺酸、白胺酸、離胺酸、甲硫胺酸、苯丙胺酸、脯胺酸、絲胺酸、蘇胺酸、色胺酸、酪胺酸、纈胺酸。在一些實施例中,非天然胺基酸可包括除了上述二十種α胺基酸之外的天然存在化合物。非天然胺基酸及非天然胺基酸併入至蛋白質序列中之方法係此項技術中已知的,例如,如美國專利第7,045,337號中所述,其內容以引用之方式併入本文中。
IV. 使用經修飾重組酶之方法 在一些實施例中,本發明提供可用於進行活體外聚合反應之經修飾重組酶及其組合物。在一些實施例中,由本發明提供之經修飾重組DNA聚合酶可用於與DNA操控(例如DNA定序)相關之活體外反應。
在其他態樣中,本發明提供可用於進行活體外聚合反應之經修飾重組酶(例如聚合酶(polymerases))。在一些實施例中,本文中所描述之聚合酶包含適用於進行定序反應之個別或呈組合形式之一或多個修飾。在一些實施例中,可利用一或多個本文中所描述之修飾來產生具有一或多個適用於進行定序反應之特性的聚合酶,例如,諸如以下之特性:聚合酶持續效力、保真性(例如精確度)、受質(例如聚磷酸核苷)結合親和力、受質利用率(例如聚磷酸核苷併入至與模板股互補之生長股中之比率)、聚合酶與經修飾受質(例如經標記聚磷酸核苷)之相互作用或其某種組合。在一些實施例中,一或多個修飾最小化或消除聚合酶之校讀能力。舉例而言,在一些實施例中,可對聚合酶之外切核酸酶域作出一或多個修飾,使得聚合酶之外切核酸酶活性受損。
在一些態樣中,本申請案係關於具有有利於單分子核酸定序技術之經改變生化特性的經修飾聚合酶。在一些實施例中,本文中所描述之變異體聚合酶已經修飾以在單分子定序反應中提供改善的信號讀出。圖1提供與即時信號讀出相關之定序反應進程之實例說明。不希望受理論所束縛,認為一些單分子核酸定序反應根據流程100 進行。
在反應開始時(第I 組),聚合酶(虛線)被限制於觀測區域中且結合於模板股及引子股。如所示,各自具有不同類型之可偵測標記之不同類型之核苷酸(例如A、G、T、C、U)存在於相同反應混合物中。當聚合酶與經發光標記之核苷酸締結時(第II 組),標記變為被限制在觀測區域中一段時間。在併入事件期間,例如,此段時間足夠接收標記及/或發出呈足以在觀測區域中偵測且鑑別其存在之量的能量。如與信號讀出102 相關之流程100 之第I 組及第II 組所說明,併入事件可以與對應於脈衝寬度pw 之時間段內之信號脈衝相關聯。
應瞭解,在一些實施例中,與併入事件相關聯之個別信號脈衝可能受各種條件影響,諸如在特定時間點上併入之核苷酸之類型或聚合酶之活性。在一些實施例中,個別信號脈衝可具有約10毫秒與約10秒之間的個別脈衝寬度。相應地,在一些實施例中,可以將個別脈衝寬度平均化以提供用於比較目的之參數。如本文所用,在一些實施例中,「脈衝寬度」係指對應於複數個個別信號脈衝之平均值的值,其中各個別信號脈衝具有個別脈衝寬度。
在一些實施例中,本申請案之經修飾聚合酶產生約10毫秒與約10秒之間的脈衝寬度。在一些實施例中,脈衝寬度為至少10毫秒且至多10秒、至少10毫秒且至多5秒、至少10毫秒且至多1秒或在約10毫秒與約1秒之間。在一些實施例中,脈衝寬度在約10與約500毫秒之間、約10與約200毫秒之間、約10與約100毫秒之間、約10與約50毫秒之間、約50毫秒與約1秒之間、約50與約500毫秒之間、約50與約200毫秒之間、約50與約100毫秒之間、約100毫秒與約1秒之間、約100與約500毫秒之間、約100與約200毫秒之間、約200毫秒與約1秒之間、約200與約500毫秒之間或約500毫秒與約1秒之間。
在核苷酸併入至生長股中且發光標記分裂之後,標記擴散至發光體積之外且在觀測區域中不再可偵測(第III 組)。亦如第III 組中所說明,在併入事件之後,聚合酶沿模板股進展,使得能夠與後續經發光標記之核苷酸締結。類似於自第I 組至第II 組之進程,在信號跡線102 中對應於自第III 組至第IV 組之進程之信號之強度自相對低強度位準增大至指示締結事件之信號脈衝。關於信號跡線102 ,併入事件與後續締結事件之間的時間段可以與脈衝間距離ipd 相關聯。
如在前文中關於脈衝寬度所詳述,在一些實施例中,與第一與第二信號脈衝之間之時間段相關聯之個別脈衝間距離可以受各種條件影響,諸如在特定時間點上聚合酶之活性或持續效力。在一些實施例中,個別脈衝間距離對應於約10毫秒與約1分鐘之間或較長的時段(例如約1秒與約60秒之間、約1秒與約30秒之間、約1秒與約20秒之間、約1秒與約10秒之間或小於約1秒)。相應地,在一些實施例中,可以將個別脈衝間距離平均化以提供用於比較目的之參數。如本文中所使用,在一些實施例中,「脈衝間距離」係指對應於複數個個別脈衝間距離之平均值的值。
在一些實施例中,本申請案之經修飾聚合酶產生約10毫秒與約10秒之間的脈衝間距離。在一些實施例中,脈衝間距離為至少10毫秒且至多10秒、至少10毫秒且至多5秒、至少10毫秒且至多1秒或在約10毫秒與約1秒之間。在一些實施例中,脈衝間距離在約10與約500毫秒之間、約10與約200毫秒之間、約10與約100毫秒之間、約10與約50毫秒之間、約50毫秒與約1秒之間、約50與約500毫秒之間、約50與約200毫秒之間、約50與約100毫秒之間、約100毫秒與約1秒之間、約100與約500毫秒之間、約100與約200毫秒之間、約200毫秒與約1秒之間、約200與約500毫秒之間或約500毫秒與約1秒之間。
在一些實施例中,可使用脈衝寬度及/或脈衝間距離之特徵來鑑別特定發光標記。在一些實施例中,可在定序反應中使用本發明之經修飾聚合酶藉由觀測一系列指示經發光標記之核苷酸之締結之脈衝寬度來測定模板股之核苷酸序列。在一些實施例中,在此過程中之假影會引起不正確定序信息。舉例而言,第V 組說明結合及釋放事件,其中經發光標記之核苷酸被限制在觀測區域中一段足以引起信號脈衝之時間但無併入事件。
如第V 組中所示,在偵測到第IV 組中之併入之後,分裂之發光標記擴散至可觀測區域( i )之外。在可觀測區域中另一經發光標記之核苷酸與聚合酶締結,發出可偵測信號( ii )。該經發光標記之核苷酸並不併入至生長股中而是與聚合酶分裂且擴散回反應混合物( iii )中。由此,在隨後成功併入相同類型之核苷酸之後(未展示),對應於第V 組之信號脈衝將引起在定序資訊讀出中之明顯插入。相應地,在一些實施例中,本申請案之經修飾重組酶具有長度足以自此等及其他此類假影事件中辨別純併入事件之脈衝寬度。在一些實施例中,本申請案之經修飾重組酶具有一或多個減小受質自聚合酶活性位點過早釋放之概率的修飾。在一些實施例中,本申請案之經修飾重組酶具有一或多個增加在受質與聚合酶活性位點締結後併入受質之概率的修飾。
在一些實施例中,本申請案之態樣可用於與生物樣品分析相關方法中。在例示性實施例中,本文中所提供之方法適用於測定樣品中之一或多個核酸或多肽之序列及/或測定樣品中是否存在一或多個核酸或多肽變異體(例如所關注基因中之一或多個突變)的技術中。在一些實施例中,可對患者樣品(例如人類患者樣品)進行測試以提供核酸序列資訊或出於診斷、預後及/或治療目的,測定一或多個相關核酸之存在或不存在。在一些實例中,診斷性測試可包括例如藉由定序個體之生物樣品中無細胞之DNA分子及/或表現產物(例如RNA)定序個體之生物樣品中核酸分子。舉例而言,本發明提供可有利地利用在同在申請中之美國專利申請案第14/543,865號;第14/543,867號;第14/543,888號;第14/821,656號;第14/821,686號;第14/821,688號;第15/161,067號;第15/161,088號;第15/161,125號;第15/255,245號;第15/255,303號;第15/255,624號;第15/261,697號;第15/261,724號;第62/289,019號;第62/296,546號;第62/310,398號;第62/339,790號;第62/343,997號;第62/344,123號及第62/426,144號中所描述之技術中之方法及組合物,各申請案之內容均以引用之方式併入本文中。
本申請案之一些態樣適用於能夠定序生物聚合物諸如核酸及蛋白質之技術。在一些實施例中,本申請案中所描述之方法及組合物可用於鑑別併入至核酸或蛋白質中之一系列核苷酸或胺基酸單體的技術(例如藉由偵測併入一系列經標記核苷酸或胺基酸單體之時程)中。在一些實施例中,本申請案中所描述之方法及組合物可以併入至鑑別一系列核苷酸的技術中,該等核苷酸係經併入至藉由聚合酶合成之模板依賴性核酸定序反應產物中。
在定序期間,聚合酶可以偶合(例如附接)於目標核酸分子之引發位置(例如定序模板之核酸分子)。引發位置可包含與目標核酸分子之部分互補之引子。作為替代方案,引發位置為提供於目標核酸分子之雙股區段內之間隙或切口。間隙或缺口之長度可以為0至至少1、2、3、4、5、6、7、8、9、10、20、30或40個核苷酸。切口可在雙股序列之一個股中提供斷裂,其可為聚合酶提供引發位置,諸如股置換聚合酶。
在一些情況下,定序引子可黏著至固定於固體支撐物或未固定固體支撐物之目標核酸分子。固體支撐物可包含,例如,用於核酸定序之積體裝置上之樣品槽。在一些實施例中,定序引子可固定於固體支撐物且目標核酸分子之雜交亦使目標核酸分子固定於固體支撐物。在一些實施例中,聚合酶固定於固體撐體且使可溶性引子及目標核酸與聚合酶接觸。然而,在一些實施例中,包含聚合酶、目標核酸及引子之複合物在溶液中形成且使複合物固定於固體支撐物(例如經由聚合酶、引子及/或目標核酸之固定)。在一些實施例中,無樣品槽中之組分固定於固體支撐物。舉例而言,在一些實施例中,包含聚合酶、目標核酸及引子之複合物在溶液中形成且複合物不固定於固體支撐物。在一些實施例中,經修飾重組酶固定於表面上。在一些實施例中,表面包含奈米孔口。在某些實施例中,奈米孔口包含底表面,該底表面包含第一材料及由複數個金屬或金屬氧化物層形成之側壁。在一些實施例中,第一材料為透明材料或玻璃。在一些實施例中,底表面為平坦的。在一些實施例中,底表面為曲面槽。在一些實施例中,底表面包括側壁的一部分,其在由多個金屬或金屬氧化物層形成的側壁下方。在一些實施例中,第一材料為熔融矽石或二氧化矽。在一些實施例中,複數個層各自包含金屬(例如,Al、Ti)或金屬氧化物(例如,Al2 O3 、TiO2 、TiN)。在一些實施例中,表面可為由玻璃或其他透明材料、矽石、熔融矽石、二氧化矽、聚合物、其他材料或其組合製成的晶片之表面(例如,不同層之組合,例如包括一或多個金屬層)。
在適當的條件下,接觸經黏著之引子/目標核酸之聚合酶可以將一或多個核苷酸添加或併入引子中,且核苷酸可以5'至3'模板依賴性方式添加至引子中。此類核苷酸併入引子上(例如經由聚合酶之作用)一般可稱作引子延長反應。各核苷酸可與可偵測標籤聯合,該標籤可在核酸延長反應期間被偵測及鑑別出(例如基於其發光壽命及/或其他特徵)且用於測定併入經延長引子及因此新合成的核酸分子序列中之各核苷酸。經由新合成之核酸分子之序列互補,亦可測定目標核酸分子之序列。在一些情況下,定序引子與目標核酸分子的黏著及核苷酸併入至定序引子可在類似反應條件(例如相同或類似反應溫度)下或在不同反應條件(例如不同反應溫度)下進行。在一些實施例中,藉由合成方法定序可包括目標核酸分子(例如目標核酸之複本)之群體及/或為獲得目標核酸群體之目標核酸擴增步驟的存在。然而,在一些實施例中,藉由合成定序用於測定受評估之各反應中之單個分子之序列(且製備用於定序之目標模板不需要核酸擴增)。在一些實施例中,根據本申請案之態樣平行進行(例如在單個積體裝置上)複數個單分子定序反應。舉例而言,在一些實施例中,複數個單分子定序反應在積體裝置上之單獨反應室中各自進行。
在一些實施例中,本發明之聚合酶適用於在顯著小體積之樣品槽中進行之單分子定序反應。舉例而言,在一些實施中,樣品槽之體積可在約10-21 升與約10-15 升之間。因為樣品槽具有較小體積,可達成單個樣品偵測事件(例如單分子事件)。在一些實施例中,表面(例如樣品槽之表面)經組態以接收本文中所描述之聚合酶。在一些實施例中,樣品槽接收可置於樣品槽之表面,諸如底表面上之聚合酶。在一些實施例中,樣品槽在積體裝置內形成,其中樣品槽之底表面位於形成其之積體裝置之表面的遠端。
在某些實施例中,本文所描述之技術係關於可添加至樣品槽中之聚合酶及其複合物。在一些實施例中,本文中所描述之聚合酶可被限制在樣品槽之目標體積(例如反應體積)內。在一些實施例中,目標體積係樣品槽中之區域。在存在一或多個待固定於底表面上之聚合酶的實施例中,可能需要將底表面官能化以使得能附接一或多個聚合酶(例如聚合酶及其複合物)。在一些實施例中,底表面使用包含偶合基團之物質官能化。舉例而言,偶合基團可包含化學部分,諸如胺基、羧基、羥基、巰基、金屬、螯合劑及類似物。替代地,其可包括特定結合單元,諸如生物素、雙生物素、抗生物素蛋白、抗生蛋白鏈菌素、中性抗生物素蛋白、凝集蛋白、SNAP-標籤™ (SNAP-tags™),或因此受質,締合或結合肽或蛋白質、抗體或抗體片段、核酸或核酸類似物或類似物。另外或替代地,偶合基團可用於偶合用於與所關注之分子(例如聚合酶或其複合物)偶合或結合的其他基團,在一些情況下其可以包括化學官能基及特定結合單元。舉例而言,偶合基團,例如生物素或雙生物素,可以沈積在受質表面上且在給定區域中選擇性地活化。中間體結合劑,例如抗生蛋白鏈菌素,可隨後偶合於第一偶合基團。所關注之分子(例如聚合酶或其複合物),其在此特定實例中係經生物素標記的,隨後偶合於抗生蛋白鏈菌素。在一些實施例中,本文中所描述之聚合酶可進一步包含能夠與將聚合酶固定於表面(例如樣品槽之表面)之偶合基團形成相互作用的偶合部分。舉例而言,在一些實施例中,聚合酶包含能夠結合於抗生素蛋白之N端或C端生物素標記或雙生物素標記序列。在一些實施例中,生物素標記或雙生物素標記序列進一步包含連接子序列。舉例而言,在一些實施例中,C端連接子/生物素標記序列包含胺基酸序列GGGSGGGSGGGSGLNDFFEAQKIEWHE (SEQ ID NO: 843)。在一些實施例中,聚合酶包含能夠結合於兩個抗生物素蛋白蛋白之結合位點的N端或C端雙生物素標記序列。舉例而言,在一些實施例中,N端或C端連接子/雙生物素標記序列包含胺基酸序列GGGGSGGGSGGGSGLNDFFEAQKIEWHEGGGSGGGSGGGSGLNDFFEAQKIEWHE (SEQ ID NO: 844)。
實例 實例 1. 經修飾聚合酶之表現及評估 在大腸桿菌中表現重組聚合酶變異體且使用His-旋轉管柱自150 mL規模培養物中純化。藉由SDS-PAGE分析蛋白質純度,隨後進行庫馬斯藍(Coomassie Blue)染色(圖7)。在緩衝交換及蛋白質濃縮之後,在dNTP存在下在30℃下追蹤捕集器30分鐘之條件下針對活性及持續效力評估重組變異體。在捕集器存在下,嵌合聚合酶變異體C017及C020展示出活性、持續效力及合成長度。量測變異體聚合酶對dNTP類似物之利用率以評估聚合酶在定序反應中之適用性。同源突變變異體及嵌合聚合酶變異體皆顯示對dN6P之利用率。來自單分子定序之結果展示於下表8中。 表8.關於經修飾聚合酶之定序結果
聚合酶 ( 名稱) 數字讀段 讀段長度 速率( 鹼基數/ 秒) 本地鹼基速率( 鹼基數/ 秒) 脈衝寬度(s) 脈衝間距離(s) 精確度
Q001 90890 10205 1.82 2.41 0.07 0.36 80.9%
Q020 79366 7973 1.67 2.42 0.08 0.35 81.6%
Q035 96323 15532 2.05 3.04 0.13 0.21 88.7%
Q036 104352 8816 1.26 2.03 0.09 0.42 84.5%
C0138 16742 3486 1.47 2.30 0.11 0.34 71.4%
C0145 3982 6287 1.52 2.66 0.10 0.29 73.0%
C0173 3360 6125 1.59 2.52 0.11 0.30 70.0%
C0186 24165 11699 1.77 2.59 0.10 0.30 73.0%
C0189 60002 2880 1.77 2.47 0.11 0.32 85.2%
C0190 8729 4938 1.15 1.67 0.33 0.29 86.0%
C0239 36908 11226 1.39 1.79 0.32 0.25 84.7%
C0256 17700 14200 2.21 3.18 0.11 0.22 90.3%
C0263 9440 7640 1.96 2.81 0.10 0.27 84.4%
C0266 34395 10183 1.42 1.85 0.29 0.26 84.9%
C0267 811 6787 1.38 1.80 0.36 0.21 88.0%
C0268 23582 6638 1.47 1.95 0.27 0.26 80.7%
C0288 40472 3763 1.22 1.77 0.33 0.24 85.0%
C0289 37754 4895 1.71 2.63 0.14 0.26 85.1%
C0290 31770 4889 1.73 2.64 0.14 0.26 85.0%
C0295 36350 3110 1.48 1.99 0.21 0.31 86.1%
C0299 40027 3243 1.62 2.37 0.10 0.34 83.0%
C0303 28410 5605 1.25 1.76 0.30 0.29 85.2%
C0307 23243 3013 1.31 1.93 0.23 0.30 84.3%
C0313 1890 11676 1.41 1.87 0.29 0.26 81.9%
C0320 372 11679 1.53 2.09 0.27 0.22 87.5%
C0321 953 12311 1.3 1.75 0.31 0.27 83.9%
C0326 23 11907 2.01 2.81 0.11 0.26 77.6%
C0327 92 22355 2.12 2.93 0.09 0.27 69.5%
C0328 375 12911 1.64 2.52 0.1 0.31 81%
C0329 1409 19941 1.78 2.61 0.09 0.31 81.2%
C0333 828 20204 1.56 2.21 0.08 0.38 76.7%
C0334 859 7597 1.19 1.8 0.32 0.26 87%
C0335 664 22145 2.05 3.07 0.1 0.24 83%
C0337 943 16926 1.99 2.96 0.1 0.25 84%
C0338 511 13170 1.37 1.86 0.3 0.25 83.8%
C0352B 5269 13946 1.92 2.69 0.13 0.26 84.6%
實例 2. 具有改良之受質利用率的經修飾聚合酶 屎腸球菌聚合酶變異體EFM37含有位置L264、V261及K500處之三個活性位點取代,其經測定以改良六磷酸受質之利用率(dN6P)。觀測到具有EFM37之啞鈴三元複合物或諸如EFM48之相關變異體,可負載於定序晶片上且基於奈米球分析使用未標記dN6P (10 μM)在樣品槽內部及上表面進行前進型DNA複製(圖8A-8D)。藉由用EFM37啞鈴三元複合物負載定序晶片,且用10 μM dN6P進行1小時複製,隨後與FAM標記之寡核苷酸探針一起培育,從而產生DNA奈米球。
在使用dN6P與染料之間含有雙螺旋DNA連接子之經染料標記之dN6P受質的後續實驗中,未觀測到即時DNA合成。短叉狀股置換DNA合成之即時停流分析用於進一步評估變異體EFM37、EFM48及EMF66。在30℃下快速添加核苷酸及Mg++ (10 mM MgCl2 )後,即時停流股置換DNA合成分析利用短叉狀DNA受質,其中引子延長引起經FAM標記之置換寡核苷酸的股置換及未淬滅(圖10A)。基於分析結果,確定相較於dN6P,與雙螺旋DNA連接子類似物之DNA合成速率大致在速率(每秒之鹼基對)上慢3-10倍(圖8C-8D)。
確定屎腸球菌具有整體帶負電表面,包括在聚合酶活性位點附近及相對較低理論等電點(pI=5.5)。基於此理解及其他觀測結果,假設帶負電核苷酸類似物與屎腸球菌聚合酶表面之間的靜電斥力提供此等類似物之不良利用率。
運算建模野生型屎腸球菌結構,且鑑別出在活性位點附近之表面位置用於引入取代,以使此區域更具正電性,且因此對帶負電類似物(包括DNA連接子類似物)更具吸引力,同時最低限度地影響結構穩定性。建模結構之描述展示於圖9A中,帶負電殘基展示有色,且催化性天冬胺酸殘基在由箭頭指示之聚合酶活性位點中之位置。如圖9B中所示,聚合酶同源域映射至屎腸球菌多肽之區域,其以N端至C端方式定向,其中指示各域之起始位置。設計總共12種影響表面電荷之取代,包括九種陰性取代,且在兩輪篩選中針對dN6P及DNA連接子類似物利用率,篩選此等取代之多個組合。
所有經篩選之屎腸球菌變異體含有與親本酶EFM37相同之三個活性位點突變(L264H、V261A、K500E),且EFM37藉由停流股置換合成分析同時進行純化及篩選,作為參考,以從其中鑑別出速率之改良。在兩輪篩選之後,相對於EFM37,鑑別兩個相關變異體EFM88及EFM89,其中dN6P (2.0-2.7倍)及DNA連接子類似物(6.3-8.7倍)兩者之併入率大部分增加(圖10A)。EFM88及EFM89皆含有九種表面電荷取代,其中之七個常見,且相對於野生型總共13種取代。此等變化使得在環繞聚合酶活性位點入口之區域中淨消除七個負電荷及添加五個正電荷(圖10B),引起此區中之靜電表面之主要重塑。建模野生型與EFM88靜電表面之間的比較展示於圖10C中。
在單分子定序反應中使用DNA連接子類似物受質評估EFM88及EFM89變異體。含有EFM88或EFM89之三元複合物產生有預致敏M13質體DNA且負載至定序晶片上。在用含有染料標記之DNA連接子類似物之緩衝劑引發定序反應後,觀測到核苷酸併入之脈衝特徵,且使用用突崩光電二極體儀器收集之資料獲得在67-82%精確度範圍內對M13參考序列之定序比對。結果展示於圖10D-10F中。與EFM89之實例比對亦展示於圖11中。
為了進一步評估此等發現,使用商業平台在其他定序反應中評估由來自兩個獨立表現及純化批次之EFM89製成的三元複合物(2 kb模板DNA,衍生自來自λ噬菌體之PCR)。兩批EFM89均顯示一致定序結果(圖12A-12D),具有74-76%精確度及大致3 kb讀段長度。
實例 3. 具有改良之穩定性的經修飾重組酶 歸因於高水準取代(總計13次)之去穩定化作用,EFM88及EFM89在單分子定序中顯示低於野生型屎腸球菌聚合酶之純化產率及活性分率,及較低負載及較短讀段長度。
使用合理設計原理及計算工具,設計三張基於EFM89之變異體的圖,其含有取代以改良穩定性:1.聚合酶活性位點中之逆轉或取代(EFM144-154);2.外切核酸酶域或TPR1子域中之新穎穩定性取代(EFM155-160);及3.位於聚合酶表面上之六個殘基處之逆轉(EFM161-166)。在此等圖之情況下,使用針對晶片上篩選優化的EFM之自動小規模純化工作流程。EFM過程之小型化涉及多個步驟之修飾及優化,包括使用試管培養、溶胞物內抗生蛋白鏈菌素複合及用與EFM相容之低嚴格度緩衝劑進行之單步純化。此方法產生野生型屎腸球菌聚合酶之較高產量及對多個候選物進行晶片上篩選之足夠產量(圖16)。
在此方法中含有單取代E60L之EFM158 (相對於EFM158)顯示顯著較高的產量(圖16)。此產量增加指示E60L之引入使得蛋白質穩定性得到很大改良。
屎腸球菌聚合酶含有位置60處之麩胺酸,而所有其他同源物含有白胺酸(參見圖17中之多個序列比對)。甚至在非常遙遠的同源物(<30%一致性)中觀測到在此位置處白胺酸之強序列保守性。此保守白胺酸殘基埋入外切核酸酶域之疏水性核心中。圖18顯示在內部屎腸球菌聚合酶晶體結構中包圍E60且在嵌合體C320中包圍L60之疏水性環境。
在商業平台上使用2 kb模板測試多個EFM變異體。此處,與其產量之顯著提高一致,EFM158顯示負載、讀段長度、N50及在6小時定序運行結束時仍具有活性之槽之百分比的主要改良(圖19)。與EFM89相比,讀段長度自3 kb增加80%至5.4 kb。歸因於改良之讀段長度分佈(圖20),EFM158的N50讀段長度自4 kb增加至8.6 kb (意謂50%資料在更長的8.6 kb讀段中)。EFM158之讀段長度增加可歸因於酶及/或三元複合物在定序條件下之增加的穩定性/可持性,如在6小時運行結束時仍主動複製之槽的百分比自0.9%至12.2%之大幅增加所指示。EFM158及野生型屎腸球菌聚合酶之表面電荷之比較提供於圖21中。
實例 4. 其他聚合酶變異體 EFM158提供用於演進具有改良之定序效能之新EFM候選物的更加堅固之主鏈。增加之產量及晶片上負載能夠實現改良之篩選方法,包括自動高通量純化及多重單分子定序。
因而,EFM158用作篩選所關注之額外EFM變異體之主鏈。多個此等EFM變異體表明提高之精確度及/或對諸如脈衝間持續時間之定序具有其他作用(圖22)、脈衝寬度及讀段長度(圖23)。
實例 5. 富集於用 EF 聚合酶進行之基於乳劑之 IVTT-RCA 篩選中的取代 對編碼EF聚合酶之基因使用誘變PCR進行隨機誘變,且將其次選殖至適合於活體外轉錄及轉譯(IVTT)表現系統中之蛋白質表現的環形構築體中,隨後進行滾環複製(IVTT-RCA)。用引子與誘變之EF聚合酶庫進行黏著以用於DNA複製,且使用微流晶片在含有IVTT組分、dNTP及Mg++之緩衝劑中乳化至毫微微升級液滴中(Leman等人. Lab Chip, 2015,15, 753-765);庫之乳化得到每個液滴單個基因。在30℃下培育乳劑16小時。以此方式,使液滴分離之EF變異體藉由RCA複製其自身基因,使得編碼含有有利取代之EF變異體之DNA序列富集,該等取代增加其複製能力;負責增加複製能力之取代可包括改良之蛋白質穩定性及產率、持續效力、股置換、DNA結合及速度。在IVTT-RCA之後,乳劑遭破壞,且回收複製之DNA並對其用引子進行PCR,該等引子經設計以自RCA產物回收含有全長基因之擴增子。使擴增子經受額外一輪IVTT-RCA選擇或與髮夾銜接子接合,且經受高通量單分子DNA定序以便鑑別所回收之基因中存在之取代。亦對起始庫進行定序(亦即在IVTT-RCA選擇之前)以充當參考物。在2輪IVTT-RCA選擇之後,藉由比較該組前後選擇序列讀段中各取代之相對豐度(含有取代之讀段之分率)來鑑別富集之取代(圖25)。
實施例 在一些實施例中,本發明提供: 1.     一種基於選自表1之第一聚合酶的重組聚合酶,其中第一聚合酶之至少一個胺基酸區段已經來自選自表1之第二聚合酶之對應胺基酸區段置換,其中第一及該第二聚合酶不同,且視情況其中重組聚合酶相對於表1之第一及/或第二聚合酶之序列進一步包含一或多個胺基酸插入、缺失或取代。在特定實施例中,第一聚合酶為屎腸球菌聚合酶(SEQ ID No: 2-5)。在特定實施例中,第一聚合酶係選自SEQ ID No. 23-33中之任一者。 2.     如段落1之重組聚合酶,其中第一聚合酶係Φ29聚合酶(SEQ ID NO: 1)且第二聚合酶係選自SEQ ID NO: 2-33中之任一者。在特定實施例中,第二聚合酶係選自SEQ ID NO: 2-5。在特定實施例中,第二聚合酶係選自SEQ ID NO: 23-33。 3.     如任何前述段落之重組聚合酶,其中第一聚合酶之至少一個至三個額外胺基酸區段已經來自表1之一或多個聚合酶之對應的胺基酸區段置換,其中表1之一或多個聚合酶不同於第一聚合酶,且視情況其中對應的胺基酸區段中之一或多者包含相對於表1中之其序列之一或多個胺基酸插入、缺失或取代。 4.     如任何前述段落之重組聚合酶,其中區段中之一或多者包含表1之聚合酶之域。 5.     如任何前述段落之重組聚合酶,其中胺基酸區段中之一或多者包含表1之聚合酶之域之一部分。 6.     如段落4或5之重組聚合酶,其中胺基酸區段中之一或多者包含一或多個在表1之聚合酶中側接該域或其部分之胺基酸。 7.     如任何先前段落之重組聚合酶,其中至少一個胺基酸插入、缺失或取代對應於在表1之不同天然存在聚合酶中發現的胺基酸插入、缺失或取代。 8.     如任何先前段落之重組聚合酶,其中至少一個胺基酸插入、缺失或取代對應於未在表1之天然存在聚合酶中發現的胺基酸插入、缺失或取代。 9.     如任何先前段落之重組聚合酶,其中一或多個對應胺基酸區段係選自由以下組成之群:來自M2Y聚合酶之胺基酸1-51、來自屎腸球菌聚合酶之胺基酸271-375、來自屎腸球菌聚合酶之胺基酸72-89及/或來自屎腸球菌聚合酶之胺基酸445-449。 10.   如任何先前段落之重組聚合酶,其中至少一個胺基酸插入、缺失或取代係在對應於選自以下位置之位置的位置處:Φ29聚合酶中之M8、V51、N62、I71、L107、K131、K135、L142、G135、L142、Y148、G197、Y224、Y226、E239、V250、N251、L253、Y281、I288、T301、R306、R308、D325、D341、K354、T368、E375、K379、Q380、A437、A444、P447、E466、D476、K478、A484、E508、D510、K512、E515、K539、D570及T571。 11.   如段落10之重組聚合酶,其包含一或多個選自以下之胺基酸取代:M8R、V51A、N62D、I71V、L107I、K131E、K135Q、L142K、Y148I、G197D、Y224K、Y226F、E239G、V250A、V250I、N251R、L253A、L253H、Y281H、I288L、T301C、R306Q、R308L、D325E、D341E、K354R、T368F、E375K、E375Y、K379R、Q380R、A437G、A444T、E466K、D476H、P477D、K478D、A484C、A484Q、A484N、A484E、A484D、A484K、A484R、A484H、A484Y及A484X (其中X表示非天然胺基酸,如本文中所描述)、E508R、D510K、D510R、K512Y、E515Q、K539E、D570S及T571V。 12.   如任何先前段落之重組聚合酶,其包含一或多個對應於以下之位置處之胺基酸取代:SEQ ID NO: 1中之I71、L107、K135、L142、G197、Y224、E239、V250、L253、E375、A437、A444、E466、D476、A484、E508、D510、K512、E515、K539、D570及T571。 13.   如段落12之重組聚合酶,其中該一或多個胺基酸取代係選自SEQ ID NO: 1中之I71V、L107I、K135Q、L142K、G197V、Y224K、E239G、V250I、L253A、E375Y、A437G、A444V、E466K、D476H、A484E、E508R、D510R、K512Y、E515Q、K539E、D570S及T571V。 14.   如任何先前段落之重組聚合酶,其包含一或多個對應於以下之位置處之胺基酸取代:SEQ ID NO: 1中之K131、K135、L142、Y148、Y224、E239、V250、L253、R306、R308、E375、A437、E466、D476、A484、E508、D510、K512、E515、K539、D570及T571。 15.   如段落14之重組聚合酶,其中該一或多個胺基酸取代係選自SEQ ID NO: 1中之K131E、K135Q、L142K、Y148I、Y224K、E239G、V250A、V250I、L253A、L253H、R306Q、R308L、E375Y、A437G、E466K、D476H、A484E、E508R、D510K、D510R、K512Y、E515Q、K539E、D570E、D570S及T571V。 16.   如段落14之重組聚合酶,其中該一或多個胺基酸取代係選自SEQ ID NO: 1中之K131E、L142K、Y148I、Y224K、E239G、V250A、L253H、E375Y、A437G、A484E、E508R、D510K、K512Y、E515Q及D570E。 17.   如任何前述段落之重組聚合酶,其中經取代區段中之至少一或多者包含外切核酸酶區域、掌型區域、TPR1區域、手指型區域、TPR2區域、拇指型區域或其中任一者之部分,且視情況包含一或多個側接胺基酸。 18.   一種重組聚合酶,其具有與表1之胺基酸序列至少60%、60-70%、70-80%或至少80%一致且包含表2-7之一或多個胺基酸修飾的胺基酸序列。在特定實施例中,表1之胺基酸序列係選自SEQ ID No. 2-5中之任一者。在特定實施例中,表1之胺基酸序列係選自SEQ ID No. 23-33中之任一者。 19.   如段落18之重組聚合酶,其中一或多個胺基酸修飾包括至少一個胺基酸突變。 20.   如段落18之重組聚合酶,其中一或多個胺基酸修飾包括至少一個域取代。 21.   如段落18之重組聚合酶,其中一或多個胺基酸修飾包括至少一個域取代及至少一個胺基酸突變。 22.   如具有選自表2之序列的段落18之重組聚合酶或具有表7中所列之修飾之組合的段落18之重組聚合酶。 23.   如段落18之重組聚合酶,其具有選自表3或表4之序列。 24.   如任何前述段落之重組聚合酶,其進一步包含純化標籤。 25.   如段落24之重組聚合酶,其中純化標籤係C端標籤。 26.   如段落24之重組聚合酶,其中純化標籤係N端標籤。 27.   如段落24、25或26之重組聚合酶,其中純化標籤為His標籤。 28.   如任何前述段落之重組聚合酶,其進一步包含偶合基團。 29.   如段落28之重組聚合酶,其中偶合基團附接在重組聚合酶之末端處。 30.   如段落28之重組聚合酶,其中偶合基團附接在重組聚合酶之N末端處。 31.   如段落28、29或30之重組聚合酶,其中偶合基團係生物素標記序列或雙生物素標記序列。 32.   如任何先前段落之重組聚合酶,其包含His標籤及生物素標記序列或雙生物素標記序列。 33.   如段落18之重組聚合酶,其固定於表面上。 34.   如段落33之重組聚合酶,其中該表面包含奈米孔口。 35.   一種經分離核酸分子,其編碼如段落18之重組聚合酶。 36.   一種組合物,其包含如段落18之重組聚合酶。 37.   一種定序核酸之方法,該方法包含使如段落18之重組聚合酶與定序反應混合物接觸。 38.   一種重組聚合酶,其具有與表1之胺基酸序列至少60%、60-70%、70-80%或至少80%一致的胺基酸序列,且包含與來自表1、表2、表3或表4之不同聚合酶之外切核酸酶區域至少60%、60-70%、70-80%或至少80%一致的外切核酸酶區域。在特定實施例中,表1之胺基酸序列係選自SEQ ID No. 2-5中之任一者。在特定實施例中,表1之胺基酸序列係選自SEQ ID No. 23-33中之任一者。 39.   一種重組聚合酶,其具有與表1之胺基酸序列至少60%、60-70%、70-80%或至少80%一致的胺基酸序列,且包含與來自表1、表2或表3之不同聚合酶之掌型區域至少60%、60-70%、70-80%或至少80%一致的掌型區域。在特定實施例中,表1之胺基酸序列係選自SEQ ID No. 2-5中之任一者。在特定實施例中,表1之胺基酸序列係選自SEQ ID No. 23-33中之任一者。 40.   一種重組聚合酶,其具有與表1之胺基酸序列至少60%、60-70%、70-80%或至少80%一致的胺基酸序列,且包含與來自表1、表2或表3之不同聚合酶之TPR1區域至少60%、60-70%、70-80%或至少80%一致的TPR1區域。在特定實施例中,表1之胺基酸序列係選自SEQ ID No. 2-5中之任一者。在特定實施例中,表1之胺基酸序列係選自SEQ ID No. 23-33中之任一者。 41.   一種重組聚合酶,其具有與表1之胺基酸序列至少60%、60-70%、70-80%或至少80%一致的胺基酸序列,且包含與來自表1、表2或表3之不同聚合酶之手指型區域至少60%、60-70%、70-80%或至少80%一致的手指型區域。在特定實施例中,表1之胺基酸序列係選自SEQ ID No. 2-5中之任一者。在特定實施例中,表1之胺基酸序列係選自SEQ ID No. 23-33中之任一者。 42.   一種重組聚合酶,其具有與表1之胺基酸序列至少80%一致的胺基酸序列,且包含與來自表1、表2或表3之不同聚合酶之TPR2區域至少80%一致的TPR2區域。在特定實施例中,表1之胺基酸序列係選自SEQ ID No. 2-5中之任一者。在特定實施例中,表1之胺基酸序列係選自SEQ ID No. 23-33中之任一者。 43.   一種重組聚合酶,其具有與表1之胺基酸序列至少60%、60-70%、70-80%或至少80%一致的胺基酸序列,且包含與來自表1、表2或表3之不同聚合酶之拇指型區域至少60%、60-70%、70-80%或至少80%一致的拇指型區域。在特定實施例中,表1之胺基酸序列係選自SEQ ID No. 2-5中之任一者。在特定實施例中,表1之胺基酸序列係選自SEQ ID No. 23-33中之任一者。 44.   一種重組聚合酶,其具有與表1之胺基酸序列至少60%、60-70%、70-80%或至少80%一致且包含兩個或更多個先前段落中之任一者之區域的胺基酸序列。在特定實施例中,表1之胺基酸序列係選自SEQ ID No. 2-5中之任一者。在特定實施例中,表1之胺基酸序列係選自SEQ ID No. 23-33中之任一者。 45.   一種定序方法,其包含使用任何先前段落之一或多個聚合酶進行定序反應。 46.   一種經修飾重組酶,其包含第一區段及第二區段,其中: 該第一區段包含對應於第一參考區段之胺基酸序列,該第一參考區段含有SEQ ID NO: 2之胺基酸197-271,其中該第一區段之胺基酸序列與該第一參考區段之胺基酸序列至少80%、80-90%、90-95%或至少95%一致,且其中該第一區段具有高於該第一參考區段之等電點;及 該第二區段包含對應於第二參考區段之胺基酸序列,該第二參考區段含有SEQ ID NO: 2之胺基酸443-528,其中該第二區段之胺基酸序列與該第二參考區段之胺基酸序列至少80%、80-90%、90-95%或至少95%一致,且其中該第二區段具有高於該第二參考區段之等電點。在特定實施例中,第一區段包含與SEQ ID NO: 2之197-271至少80%、80-90%、90-95%或至少95%一致之胺基酸序列,且第二區段包含與SEQ ID NO: 2之胺基酸443-528至少80%、80-90%、90-95%或至少95%一致之胺基酸序列。 47.   一種包含第一區段之經修飾重組酶,該第一區段包含對應於參考區段之胺基酸序列,該參考區段含有SEQ ID NO: 2之胺基酸1-196,其中該第一區段之胺基酸序列與該參考區段之胺基酸序列至少80%、80-90%、90-95%或至少95%一致;且其中該第一區段具有高於該參考區段之等電點。在特定實施例中,第一區段包含與SEQ ID NO: 2之1-196至少80%、80-90%、90-95%或至少95%一致之胺基酸序列。 48.   一種經修飾重組酶,其包含第一區段及第二區段,其中: 該第一區段包含對應於第一參考區段之胺基酸序列,該第一參考區段含有SEQ ID NO: 2之胺基酸1-271,其中該第一區段之胺基酸序列與該第一參考區段之胺基酸序列至少80%、80-90%、90-95%或至少95%一致,且其中該第一區段具有高於該第一參考區段之等電點;及 該第二區段包含對應於第二參考區段之胺基酸序列,該第二參考區段含有SEQ ID NO: 2之胺基酸443-528,其中該第二區段之胺基酸序列與該第二參考區段之胺基酸序列至少80%、80-90%、90-95%或至少95%一致,且其中該第二區段具有高於該第二參考區段之等電點。在特定實施例中,第一區段包含與SEQ ID NO: 2之1-271至少80%、80-90%、90-95%或至少95%一致之胺基酸序列,且第二區段包含與SEQ ID NO: 2之胺基酸443-528至少80%、80-90%、90-95%或至少95%一致之胺基酸序列。 49.   如段落46至48中任一項之經修飾重組酶,其中經修飾重組酶之胺基酸序列包含對應於以下之一或多個位置處之修飾:SEQ ID NO: 2之K4、T13、S22、V25、C26、D27、N33、I34、F36、S42、D54、N59、E60、E65、E85、M95、N106、T110、T114、K119、Q122、Y133、P136、E139、E142、N145、P147、I148、E152、I153、P160、D167、D171、N175、F188、D189、Q206、T211、S216、R217、D232、A236、V247、I253、V261、L264、S267、V443、L445、A446、S447、V449、T450、W452、G453、Y455、F465、N467、T479、E482、A484、E485、A486、L490、D492、S493、K495、K500、S503、Q506、Q513、E519、D521、E523及V526。 50.   如段落49之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:K4R、T13N、S22A、V25L、C26W、D27E、N33T、I34V、F36V、S42T、D54Y、N59D、E60L、E60V、E65S、E85P、M95T、M95K、N106G、T110I、T114S、K119Q、Q122V、Y133L、P136T、E139K、E139Q、E139R、E139H、E142K、E142Q、E142R、E142H、N145K、P147Q、P147T、I148K、I148H、I148R、E152D、I153V、P160A、D167P、D167K、D171K、D171H、D171R、N175T、F188C、D189K、D189H、D189R、Q206R、Q206K、Q206H、T211A、S216G、S216R、R217G、D232K、A236G、V247D、I253H、I253A、V261A、V261I、V261L、L264H、L264A、L264M、S267A、V443T、L445M、A446G、S447V、V449I、T450A、W452Y、G453A、Y455W、F465Y、N467R、N467K、N467H、N467S、N467T、T479V、E482K、E482H、E482R、A484E、E485D、A486E、L490M、D492H、D492K、D492R、D492A、H492S、S493P、K495R、K500E、S503A、S503T、Q506K、Q513D、D521K、D521R、D521H、E523R、E523V、E523Y、E523F、E523H、E523W及V526L。 51.   如段落49或段落50之經修飾重組酶,其中經修飾重組酶之胺基酸序列包含對應於以下之一或多個位置處之修飾:E139、E142、N145、I148、D167、D171、D189、N467、E482、D492、K495、D521及E523。 52.   如段落51之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:E139K、E139Q、E139R、E139H、E142K、E142H、E142R、E142Q、N145K、I148K、I148H、I148R、D167P、D167K、D171K、D171H、D171R、D189K、D189H、D189R、N467R、N467K、N467H、N467S、N467T、E482K、E482H、E482R、D492H、D492K、D492R、K495R、D521K、D521H、D521R、E523K、E523Y、E523H、E523R、E523F及E523W。 53.   如段落46至52中任一項之經修飾重組酶,其中經修飾重組酶之胺基酸序列包含對應於以下之一或多個位置處之修飾:SEQ ID NO: 2之P273、P275、R308、V315、Q317、S319、L320、I322、Q323、D337、E338、D341、T345、F352、F353、T364、D374、I384、E385、N388、E391、A396、N397、G400、D414、D425、R429、E436、L437、D533、R534、E537、G547、E545、L555、P556、R558、T559、V564、T568、M569及T571。 54.如段落53之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:P273S、P275S、E283K、V315L、S319R、R308G、G308R、Q317R、S319R、L320M、L320T、I322K、Q323G、Q323V、Q323R、D337G、E338K、D341T、T345I、F352I、F353C、T364I、D374G、I384T、I384F、I384S、E385Y、E385Y、N388T、E391Y、E391W、E391F、E391H、E391M、E391K、E391R、A396Q、N397L、G400L、D414V、D425N、R429G、E436R、E436G、L437Y、L437E、D533A、R534K、E537K、E537H、E537R、E545K、G547S、L555K、L555R、P556A、R558H、T559V、V564L、T568D、T568S、M569K、M569T、M569V及T571S。 55.   如段落53之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:D374G、E385Y、E391Y、E391W、E391K、E391F、D533A、E537K、E537H、E537R及E545K。 56.   如段落53至55中任一項之經修飾重組酶,其中經修飾重組酶包含表7中所列之修飾之組合。 57.   如段落53至55中任一項之經修飾重組酶,其中經修飾重組酶之胺基酸序列包含對應於以下之位置處之修飾:E142、I148、D189、V261、L264、R308、E391、E482、D492、K500、D521、E523及E537。 58.   如段落57之經修飾重組酶,其中: 位置E142處之修飾為E142K; 位置I148處之修飾為I148K; 位置D189處之修飾為D189K; 位置V261處之修飾為V261A; 位置L264處之修飾為L264H; 位置R308處之修飾為R308G; 位置E391處之修飾為E391Y; 位置E482處之修飾為E482K; 位置D492之修飾為D492H; 位置K500處之修飾為K500E; 位置D521處之修飾為D521K; 位置E523處之修飾為E523K;及 位置E537處之修飾為E537K。 59.   如段落58之經修飾重組酶,其中經修飾重組酶包含SEQ ID NO: 88之胺基酸序列。 60.   如段落58之經修飾重組酶,其中經修飾重組酶之胺基酸序列包含位置E60處之修飾。 61.   如段落60之經修飾重組酶,其中E60處之修飾為E60L。 62.   如段落61之經修飾重組酶,其中經修飾重組酶包含SEQ ID NO: 157之胺基酸序列。 63.   如段落61之經修飾重組酶,其中經修飾重組酶進一步包含雙生物素標籤。 64.   如段落63之經修飾重組酶,其中經修飾重組酶包含SEQ ID NO: 180之胺基酸序列。 65.   一種經修飾重組酶,其包含一或多個選自以下之區段: 具有與SEQ ID NO: 2之胺基酸1-196至少80%、80-90%、90-95%或至少95%一致之胺基酸序列的第一區段,其中該第一區段之胺基酸序列包含對應於以下之一或多個位置處之修飾:SEQ ID NO: 2之K4、T13、S22、V25、C26、D27、N33、I34、F36、S42、D54、N59、E60、E65、E85、M95、N106、T110、T114、K119、Q122、Y133、P136、E139、E142、N145、P147、I148、E152、I153、P160、D167、D171、N175、F188及D189; 具有與SEQ ID NO: 2之胺基酸197-271至少80%、80-90%、90-95%或至少95%一致之胺基酸序列的第二區段,其中該第二區段之胺基酸序列包含對應於以下之一或多個位置處之修飾:SEQ ID NO: 2之Q206、T211、S216、R217、D232、A236、V247、I253、V261、L264及S267;及/或 具有與SEQ ID NO: 2之胺基酸443-528至少80%、80-90%、90-95%或至少95%一致之胺基酸序列的第三區段,其中該第三區段之胺基酸序列包含對應於以下之一或多個位置處之修飾:SEQ ID NO: 2之V443、L445、A446、S447、V449、T450、W452、G453、Y455、F465、N467、T479、E482、A484、E485、A486、L490、D492、S493、K495、K500、S503、Q506、Q513、E519、D521、E523及V526。 66.   如段落65之經修飾重組酶,其中經修飾重組酶包含第一區段及第二區段。 67.   如段落65之經修飾重組酶,其中經修飾重組酶包含第二區段及第三區段。 68.   如段落65之經修飾重組酶,其中經修飾重組酶包含第一區段及第三區段。 69.   如段落65之經修飾重組酶,其中經修飾重組酶包含第一區段、第二區段及第三區段。 70.   如段落65至69中任一項之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:K4R、T13N、S22A、V25L、C26W、D27E、N33T、I34V、F36V、S42T、D54Y、N59D、E60L、E60V、E65S、E85P、M95T、M95K、N106G、T110I、T114S、K119Q、Q122V、Y133L、P136T、E139K、E139Q、E139R、E139H、E142K、E142Q、E142R、E142H、N145K、P147Q、P147T、I148K、I148H、I148R、E152D、I153V、P160A、D167P、D167K、D171K、D171H、D171R、N175T、F188C、D189K、D189H、D189R、Q206R、Q206K、Q206H、T211A、S216G、S216R、R217G、D232K、A236G、V247D、I253H、I253A、V261A、V261I、V261L、L264H、L264A、L264M、S267A、V443T、L445M、A446G、S447V、V449I、T450A、W452Y、G453A、Y455W、F465Y、N467R、N467K、N467H、N467S、N467T、T479V、E482K、E482H、E482R、A484E、E485D、A486E、L490M、D492H、D492K、D492R、D492A、H492S、S493P、K495R、K500E、S503A、S503T、Q506K、Q513D、D521K、D521R、D521H、E523R、E523V、E523Y、E523F、E523H、E523W及V526L。 71.   如段落65至70中任一項之經修飾重組酶,其中經修飾重組酶之胺基酸序列包含對應於以下之一或多個位置處之修飾:E139、E142、N145、I148、D167、D171、D189、N467、E482、D492、K495、D521及E523。 72.   如段落71之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:E139K、E139Q、E139R、E139H、E142K、E142H、E142R、E142Q、N145K、I148K、I148H、I148R、D167P、D167K、D171K、D171H、D171R、D189K、D189H、D189R、N467R、N467K、N467H、N467S、N467T、E482K、E482H、E482R、D492H、D492K、D492R、K495R、D521K、D521H、D521R、E523K、E523Y、E523H、E523R、E523F及E523W。 73.   如段落65至72中任一項之經修飾重組酶,其中經修飾重組酶之胺基酸序列包含對應於以下之一或多個位置處之修飾:SEQ ID NO: 2之P273、P275、R308、V315、Q317、S319、L320、I322、Q323、D337、E338、D341、T345、F352、F353、T364、D374、I384、E385、N388、E391、A396、N397、G400、D414、D425、R429、E436、L437、D533、R534、E537、G547、E545、L555、P556、R558、T559、V564、T568、M569及T571。 74.   如段落73之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:P273S、P275S、E283K、V315L、S319R、R308G、G308R、Q317R、S319R、L320M、L320T、I322K、Q323G、Q323V、Q323R、D337G、E338K、D341T、T345I、F352I、F353C、T364I、D374G、I384T、I384F、I384S、E385Y、N388T、E391Y、E391W、E391F、E391H、E391M、E391K、E391R、A396Q、N397L、G400L、D414V、D425N、R429G、E436R、E436G、L437Y、L437E、D533A、R534K、E537K、E537H、E537R、E545K、G547S、L555K、L555R、P556A、R558H、T559V、V564L、T568D、T568S、M569K、M569T、M569V及T571S。 75.   如段落73之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:D374G、E385Y、E391Y、E391W、E391K、E391F、D533A、E537K、E537H、E537R及E545K。 76.   如段落73至75中任一項之經修飾重組酶,其中經修飾重組酶包含表7中所列之修飾之組合。 77.   如段落73至76中任一項之經修飾重組酶,其中經修飾重組酶之胺基酸序列包含對應於以下之位置處之修飾:E142、I148、D189、V261、L264、R308、E391、E482、D492、K500、D521、E523及E537。 78.   如段落77之經修飾重組酶,其中: 位置E142處之修飾為E142K; 位置I148處之修飾為I148K; 位置D189處之修飾為D189K; 位置V261處之修飾為V261A; 位置L264處之修飾為L264H; 位置R308處之修飾為R308G; 位置E391處之修飾為E391Y; 位置E482處之修飾為E482K; 位置D492之修飾為D492H; 位置K500處之修飾為K500E; 位置D521處之修飾為D521K; 位置E523處之修飾為E523K;及 位置E537處之修飾為E537K。 79.   如段落78之經修飾重組酶,其中經修飾重組酶包含SEQ ID NO: 88之胺基酸序列。 80.   如段落78之經修飾重組酶,其中經修飾重組酶之胺基酸序列包含位置E60之修飾。 81.   如段落80之經修飾重組酶,其中E60處之修飾為E60L。 82.   如段落81之經修飾重組酶,其中經修飾重組酶包含SEQ ID NO: 157之胺基酸序列。 83.   如段落81之經修飾重組酶,其中經修飾重組酶進一步包含雙生物素標籤。 84.   如段落83之經修飾重組酶,其中經修飾重組酶包含SEQ ID NO: 180之胺基酸序列。 85.   一種經修飾重組酶,其包含含有以下之胺基酸序列:(i)第一區段、第二區段、第三區段、第四區段、第五區段、第六區段及第七區段;及(ii)在對應於SEQ ID NO: 2之E139、E142、N145、I148、D167、D171、D189、D374、E385、E391、N467、E482、D492、K495、D521、E523、D533、E537及E545之一或多個位置處之修飾;其中 該第一區段包含與表1、表2或表3之聚合酶之外切核酸酶區域至少80%、80-90%、90-95%或至少95%一致的胺基酸序列; 該第二區段及該第六區段共同包含與表1、表2或表3之聚合酶之掌型區域至少80%、80-90%、90-95%或至少95%一致的胺基酸序列; 該第三區段包含與表1、表2或表3之聚合酶之TPR1區域至少80%、80-90%、90-95%或至少95%一致的胺基酸序列; 該第四區段包含與表1、表2或表3之聚合酶之手指型區域至少80%、80-90%、90-95%或至少95%一致的胺基酸序列; 該第五區段包含與表1、表2或表3之聚合酶之TPR2區域至少80%、80-90%、90-95%或至少95%一致的胺基酸序列;及 該第七區段包含與表1、表2或表3之聚合酶之拇指型區域至少80%、80-90%、90-95%或至少95%一致的胺基酸序列。在特定實施例中,來自表1之聚合酶係選自SEQ ID No: 2-5中之任一者。在一些實施例中,來自表1之聚合酶係選自SEQ ID NO: 23-33中之任一者。 86.     如段落85之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:E139K、E139Q、E139R、E139H、E142K、E142H、E142R、E142Q、N145K、I148K、I148H、I148R、D167P、D167K、D171K、D171H、D171R、D189K、D189H、D189R、D374G、E385Y、E391Y、E391W、E391K、E391F、N467R、N467K、N467H、N467S、N467T、E482K、E482H、E482R、D492H、D492K、D492R、K495R、D521K、D521H、D521R、E523K、E523Y、E523H、E523R、E523F、E523W、D533A、E537K、E537H、E537R及E545K。 87.     如段落85或86之經修飾重組酶,其進一步包含一或多個對應於以下之位置處之修飾:SEQ ID NO: 2之K4、T13、S22、V25、C26、D27、N33、I34、F36、S42、D54、N59、E60、E65、E85、M95、N106、T110、T114、K119、Q122、Y133、P136、P147、E152、I153、P160、N175、F188、Q206、T211、S216、R217、D232、A236、V247、I253、V261、L264、S267、P273、P275、R308、V315、Q317、S319、L320、I322、Q323、D337、E338、D341、T345、F352、F353、T364、I384、N388、A396、N397、G400、D414、D425、R429、E436、L437、V443、L445、A446、S447、V449、T450、W452、G453、Y455、F465、T479、A484、E485、A486、L490、S493、K500、S503、Q506、Q513、E519、V526、R534、G547、L555、P556、R558、T559、V564、T568、M569及T571。 88.     如段落87之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:K4R、T13N、S22A、V25L、C26W、D27E、N33T、I34V、F36V、S42T、D54Y、N59D、E60L、E60V、E65S、E85P、M95T、M95K、N106G、T110I、T114S、K119Q、Q122V、Y133L、P136T、P147Q、P147T、E152D、I153V、P160A、N175T、F188C、Q206R、Q206K、Q206H、T211A、S216G、S216R、R217G、D232K、A236G、V247D、I253H、I253A、V261A、V261I、V261L、L264H、L264A、L264M、S267A、P273S、P275S、E283K、V315L、S319R、R308G、G308R、Q317R、S319R、L320M、L320T、I322K、Q323G、Q323V、Q323R、D337G、E338K、D341T、T345I、F352I、F353C、T364I、I384T、I384F、I384S、N388T、A396Q、N397L、G400L、D414V、D425N、R429G、E436R、E436G、L437Y、L437E、V443T、L445M、A446G、S447V、V449I、T450A、W452Y、G453A、Y455W、F465Y、T479V、A484E、E485D、A486E、L490M、S493P、K500E、S503A、S503T、Q506K、Q513D、V526L、R534K、G547S、L555K、L555R、P556A、R558H、T559V、V564L、T568D、T568S、M569K、M569T、M569V及T571S。 89.     如段落87或88之經修飾重組酶,其中經修飾重組酶包含表7中所列之修飾之組合。 90.     一種經修飾重組酶,其包含: 與SEQ ID NO: 2至少60%、60-70%、70-80%或至少80%一致的胺基酸序列;及 延長掌型域,其中該延長掌型域包含與SEQ ID NO: 1之胺基酸505-524至少80%、80-90%、90-95%或至少95%一致之胺基酸序列。 91.     如段落90之經修飾重組酶,其進一步包含一或多個對應於以下之位置處之修飾:SEQ ID NO: 2之K4、T13、S22、V25、C26、D27、N33、I34、F36、S42、D54、N59、E60、E65、E85、M95、N106、T110、T114、K119、Q122、Y133、P136、E139、E142、N145、P147、I148、E152、I153、P160、D167、D171、N175、F188、D189、Q206、T211、S216、R217、D232、A236、V247、I253、V261、L264、S267、V443、L445、A446、S447、V449、T450、W452、G453、Y455、F465、N467、T479、E482、A484、E485、A486、L490、D492、S493、K495、K500、S503、Q506、Q513、E519、D521、E523及V526。 92.     如段落91之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:K4R、T13N、S22A、V25L、C26W、D27E、N33T、I34V、F36V、S42T、D54Y、N59D、E60L、E60V、E65S、E85P、M95T、M95K、N106G、T110I、T114S、K119Q、Q122V、Y133L、P136T、E139K、E139Q、E139R、E139H、E142K、E142Q、E142R、E142H、N145K、P147Q、P147T、I148K、I148H、I148R、E152D、I153V、P160A、D167P、D167K、D171K、D171H、D171R、N175T、F188C、D189K、D189H、D189R、Q206R、Q206K、Q206H、T211A、S216G、S216R、R217G、D232K、A236G、V247D、I253H、I253A、V261A、V261I、V261L、L264H、L264A、L264M、S267A、V443T、L445M、A446G、S447V、V449I、T450A、W452Y、G453A、Y455W、F465Y、N467R、N467K、N467H、N467S、N467T、T479V、E482K、E482H、E482R、A484E、E485D、A486E、L490M、D492H、D492K、D492R、D492A、H492S、S493P、K495R、K500E、S503A、S503T、Q506K、Q513D、D521K、D521R、D521H、E523R、E523V、E523Y、E523F、E523H、E523W及V526L。 93.     如段落91或92之經修飾重組酶,其中經修飾重組酶之胺基酸序列進一步包含對應於以下之一或多個位置處之修飾:E139、E142、N145、I148、D167、D171、D189、N467、E482、D492、K495、D521及E523。 94.     如段落93之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:E139K、E139Q、E139R、E139H、E142K、E142H、E142R、E142Q、N145K、I148K、I148H、I148R、D167P、D167K、D171K、D171H、D171R、D189K、D189H、D189R、N467R、N467K、N467H、N467S、N467T、E482K、E482H、E482R、D492H、D492K、D492R、K495R、D521K、D521H、D521R、E523K、E523Y、E523H、E523R、E523F及E523W。 95.     如段落91至94中任一項之經修飾重組酶,其中經修飾重組酶之胺基酸序列包含對應於以下之一或多個位置處之修飾:SEQ ID NO: 2之P273、P275、R308、V315、Q317、S319、L320、I322、Q323、D337、E338、D341、T345、F352、F353、T364、D374、I384、E385、N388、E391、A396、N397、G400、D414、D425、R429、E436、L437、D533、R534、E537、G547、E545、L555、P556、R558、T559、V564、T568、M569及T571。 96.     如段落95之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:P273S、P275S、E283K、V315L、S319R、R308G、G308R、Q317R、S319R、L320M、L320T、I322K、Q323G、Q323V、Q323R、D337G、E338K、D341T、T345I、F352I、F353C、T364I、D374G、I384T、I384F、I384S、E385Y、N388T、E391Y、E391W、E391F、E391H、E391M、E391K、E391R、A396Q、N397L、G400L、D414V、D425N、R429G、E436R、E436G、L437Y、L437E、D533A、R534K、E537K、E537H、E537R、E545K、G547S、L555K、L555R、P556A、R558H、T559V、V564L、T568D、T568S、M569K、M569T、M569V及T571S。 97.     如段落95之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:D374G、E385Y、E391Y、E391W、E391K、E391F、D533A、E537K、E537H、E537R及E545K。 98.     如段落95至97中任一項之經修飾重組酶,其中經修飾重組酶包含表7中所列之修飾之組合。 99.     一種經修飾重組酶,其具有與SEQ ID NO: 1-33中之任一者至少60%、60-70%、70-80%或至少80%一致之胺基酸序列,其中該胺基酸序列包含對應於以下之一或多個位置處之修飾:屎腸球菌聚合酶(SEQ ID NO: 2)之K4、T13、S22、V25、C26、D27、N33、I34、F36、S42、D54、N59、E60、E65、E85、M95、N106、T110、T114、K119、Q122、Y133、P136、E139、E142、N145、P147、I148、E152、I153、P160、D167、D171、N175、F188、D189、Q206、T211、S216、R217、D232、A236、V247、I253、V261、L264、S267、P273、P275、R308、V315、Q317、S319、L320、I322、Q323、D337、E338、D341、T345、F352、F353、T364、D374、I384、E385、N388、E391、A396、N397、G400、D414、D425、R429、E436、L437、V443、L445、A446、S447、V449、T450、W452、G453、Y455、F465、N467、T479、E482、A484、E485、A486、L490、D492、S493、K495、K500、S503、Q506、Q513、E519、D521、E523、V526、D533、R534、E537、G547、E545、L555、P556、R558、T559、V564、T568、M569及T571。在特定實施例中,經修飾重組酶具有與SEQ ID NO: 2-5中之任一者至少60%、60-70%、70-80%或至少80%一致之胺基酸序列且包含一或多個位置處之修飾。在一個特定實施例中,經修飾重組酶為具有與SEQ ID NO: 2中之任一者至少60%、60-70%、70-80%或至少80%一致之胺基酸序列的經修飾屎腸球菌聚合酶,且包含該等位置中之一或多者處之修飾。在一個特定實施例中,經修飾重組酶為包含SEQ ID NO: 2之胺基酸序列的經修飾屎腸球菌聚合酶,且包含該等位置中之一或多者處之修飾。在一些實施例中,經修飾重組酶具有與SEQ ID NO: 23-33中之任一者60%、60-70%、70-80%或至少80%一致之胺基酸序列,且包含一或多個位置處之修飾。 100.   如段落99之經修飾重組酶,其包含對應於SEQ ID NO: 2之T568及M569的一個或兩個位置處之修飾。 101.   如段落100之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:T568D、T568S、M569T及M569V。 102.   如段落100或段落101之經修飾重組酶,其中經修飾重組酶相對於屎腸球菌聚合酶(SEQ ID NO: 2)具有改良之持續效力。 103.   如段落99至102中任一項之經修飾重組酶,其包含對應於SEQ ID NO: 2之N59的位置處之修飾。 104.   如段落103之經修飾重組酶,其中該修飾為N59D。 105.   如段落103或段落104之經修飾重組酶,其中經修飾重組酶相對於屎腸球菌聚合酶(SEQ ID NO: 2)具有改變之外切核酸酶活性。 106.   如段落99至105中任一項之經修飾重組酶,其包含一或多個對應於SEQ ID NO: 2之V261、L264、S267、I384、E391、W452、G453、Y455、D492及K500的位置處之修飾。 107.   如段落106之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:V261A、V261I、L264A、L264H、L264M、S267A、I384F、I384S、E391Y、E391W、E391F、E391H、E391M、E391K、E391R、W452Y、G453A、Y455W、D492H及K500E。 108.   如段落106或段落107之經修飾重組酶,其中經修飾重組酶相對於屎腸球菌聚合酶(SEQ ID NO: 2)具有改良之核苷酸受質利用率。 109.   如段落99至108中任一項之經修飾重組酶,其包含一或多個對應於以下之位置處之修飾:SEQ ID NO: 2之E65、Y133、E391、G400、V443、L445、A446、S447、V449、T450、S503、E523、L555及P556。 110.   如段落109之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:E65S、Y133L、E391Y、E391W、E391F、E391K、G400L、V443T、L445M、A446G、S447V、V449I、T450A、S503A、E523K、E523Y、E523F、E523H、E523W、L555K及P556A。 111.   如段落109或段落110之經修飾重組酶,其中經修飾重組酶相對於屎腸球菌聚合酶(SEQ ID NO: 2)具有改良之精確度。 112.   如請求項99至111中任一項之經修飾重組酶,其包含一或多個對應於SEQ ID NO: 2之Q317、S319、I322、Q323、R429、L555及T559的位置處之修飾。 113.   如段落112之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:Q317R、S319R、I322K、Q323G、R429G、L555K及T559V。 114.   如段落112或段落113之經修飾重組酶,其中經修飾重組酶相對於屎腸球菌聚合酶(SEQ ID NO: 2)具有增加之DNA結合親和力。 115.   如段落99至114中任一項之經修飾重組酶,其包含一或多個對應於SEQ ID NO: 2之E391、S503及E523的位置處之修飾。 116.   如段落115之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:E391Y、E391W、E391F、E391K、S503A、E523K、E523Y、E523F、E523H及E523W。 117.   如段落115或段落116之經修飾重組酶,其中經修飾重組酶相對於屎腸球菌聚合酶(SEQ ID NO: 2)具有增加之類似物結合親和力。 118.   如段落99至117中任一項之經修飾重組酶,其包含一或多個對應於SEQ ID NO: 2之Q206、E436及L437的位置處之修飾。 119.   如段落118之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:Q206R、Q206K、Q206H、E436R、L437Y及L437E。 120.   如段落118或段落119之經修飾重組酶,其中經修飾重組酶相對於屎腸球菌聚合酶(SEQ ID NO: 2)具有改良之股置換。 121.   如段落99至120中任一項之經修飾重組酶,其包含一或多個對應於SEQ ID NO: 2之E436、L437、R534、T568及M569的位置處之修飾。 122.   如段落121之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:E436R、L437Y、L437E、R534K、T568D、T568S、M569T及M569V。 123.   如段落121或段落122之經修飾重組酶,其中經修飾重組酶相對於屎腸球菌聚合酶(SEQ ID NO: 2)具有增強之平均閱讀長度。 124.   如段落99至123中任一項之經修飾重組酶,其包含一或多個對應於以下之位置處之修飾:SEQ ID NO: 2之T13、V25、C26、D27、N33、I34、F36、S42、D54、M95、T110、T114、K119、P136、P147、E152、I153、P160、N175、F188、S216、R217、D232、A236、V247、P273、E283、V315、S319、L320、Q323、E338、T345、F352、F353、T364、D414、D425、E436、F465、E485、A486、L490、S503、E523、V526、G547、L555、R558、V564、M569及T571。 125.   如段落124之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:T13N、V25L、C26W、D27E、N33T、I34V、F36V、S42T、D54Y、M95T、M95K、T110I、T114S、K119Q、P136T、P147Q、P147T、E152D、I153V、P160A、N175T、F188C、S216G、S216R、R217G、D232H、A236G、V247D、P273S、E283K、V315L、S319R、L320M、L320T、Q323R、E338K、T345I、F352I、F353C、T364I、D414V、D425N、E436G、F465Y、E485D、A486E、L490M、S503T、E523V、V526L、G547S、L555R、R558H、V564L、M569K及T571S。 126.   如段落124或段落125之經修飾重組酶,其中經修飾重組酶相對於屎腸球菌聚合酶(SEQ ID NO: 2)具有增加之複製能力。 127.   如段落99至126中任一項之經修飾重組酶,其包含對應於以下之一或多個位置處之修飾:SEQ ID NO: 2之E139、E142、N145、I148、D167、D171、D189、D374、E385、E391、N467、E482、D492、K495、D521、E523、D533、E537及E545。 128.   如段落127之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:E139K、E139Q、E139R、E139H、E142K、E142H、E142R、E142Q、N145K、I148K、I148H、I148R、D167P、D167K、D171K、D171H、D171R、D189K、D189H、D189R、D374G、E385Y、E391Y、E391W、E391K、E391F、N467R、N467K、N467H、N467S、N467T、E482K、E482H、E482R、D492H、D492K、D492R、K495R、D521K、D521H、D521R、E523K、E523Y、E523H、E523R、E523F、E523W、D533A、E537K、E537H、E537R及E545K。 129.   如段落127或段落128之經修飾重組酶,其中經修飾重組酶相對於屎腸球菌聚合酶(SEQ ID NO: 2)具有增加之正電性表面電荷。 130.   如段落99至129中任一項之經修飾重組酶,其包含一或多個對應於以下之位置處之修飾:SEQ ID NO: 2之K4、S22、D27、I34、D54、E60、E85、M95、N106、T110、Q122、Y133、P136、P147、D167、T211、D232、P275、R308、S319、L320、E323、D337、E338、D341、T345、F352、T364、D414、F465、T479、E485、L490、S493、Q513及R558。 131.   如段落130之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:K4R、S22A、D27E、I34V、D54Y、E60V、E60L、E85P、M95K、T110I、N106G、Q122V、Y133L、P136T、P147Q、P147T、D167P、T211A、D232K、P275S、R308G、S319R、L320M、Q323V、D337G、E338K、D341T、T345I、F352I、T364I、D414V、F465Y、T479V、E485D、L490M、S493P、Q513D及R558H。 132.   如段落130或段落131之經修飾重組酶,其中經修飾重組酶相對於屎腸球菌聚合酶(SEQ ID NO: 2)具有增加之穩定性。 133.   如段落99至132中任一項之經修飾重組酶,其中經修飾重組酶包含表7中所列之修飾之組合。 134.   一種組合物,其包含如段落46至133中任一項之經修飾重組酶。 135.   一種定序核酸之方法,該方法包含使如段落46至133中任一項之經修飾重組酶與定序反應混合物接觸。
本說明書中揭示之所有特點可以任何組合形式組合。本說明書中揭示之各特點可經服務相同、等效或類似目的之替代特點置換。因此,除非另外明確說明,否則所揭示之各特點僅為等效或類似特點之通用系列的一個實例。
根據以上描述,熟悉此項技術者可易於確定本發明之基本特徵,且在不脫離本發明之精神及範疇的情況下可對本發明作出各種改變及修改以使其適應各種用途及條件。因此,其他實施例亦屬於申請專利範圍內。
等效物及範疇 儘管本文中已描述及說明若干個發明實施例,但一般技術者將容易設想多種其他方法及/或結構來執行功能及/或獲得本文所述之結果及/或一或多種優點,且此類變更及/或潤飾中之每一者視為屬於本文所述之本發明實施例之範疇內。更一般化地,熟習此項技術者將易於瞭解本文所述之所有參數、尺寸、物質及組態意欲為例示性且實際參數、尺寸、材料及/或組態將視使用發明的教示所針對之特定應用或應用而定。熟悉此項技術者將認識到或使用不多於常規實驗便能夠確定本文所描述之特定本發明實施例之許多等效物。因此,應理解前述實施例僅借助於實例展現且在隨附申請專利範圍及其等效物之範疇內,發明性實施例可以不同於具體描述及主張之其他方式來實踐。本發明之發明性實施例係關於本文所述之各個別特點、系統、物品、材料、套組及/或方法。另外,若兩種或更多種此類特點、系統、物品、材料、套組及/或方法彼此間無不一致,則此類特點、系統、物品、材料、套組及/或方法之任何組合包括於本發明之發明範疇內。
如本文所定義及使用之所有定義應理解為高於辭典定義、以引用方式所併入之文獻中的定義及/或所定義術語之普通含義。
本文中所揭示之所有參考、專利及專利申請案以引用之方式相關於各自經引用之主題併入,其在一些情況下可涵蓋文件之全部內容。
除非有清晰相反指示,否則如在本說明書及申請專利範圍中所使用之詞「一」應被理解為意謂「至少一個」。
如本文在說明書及申請專利範圍中使用之片語「及/或」應理解為意謂如此結合之要素的「任一者或兩者」,亦即,在一些情況下結合地存在且在其他情況下未結合地存在的要素。使用「及/或」列出之多個元素應以相同方式解釋,亦即,如此結合之「一或多個」元素。可視情況存在除了藉由「及/或」子句所具體標識之元素之外的其他元素,無論與具體標識之彼等元素相關或無關。因此,作為非限制性實例,指代「A及/或B」在結合諸如「包含」等開放式措辭使用時,在一個實施例中,可僅指A (視情況包括除了B以外之要素);在另一實施例中,可僅指B (視情況包括除了A以外之要素);在另一實施例中,可指A及B兩者(視情況包括其他要素);等。
如在本說明書及申請專利範圍中所用,「或」應理解為具有與上文所定義之「及/或」相同的含義。舉例而言,當分離清單中之項目時,「或」或「及/或」應解釋為包括性的,亦即,包括要素之數目或清單及(視情況)額外未列出項目的至少一個以及多於一個。截然相反的術語,諸如「中之僅一者」或「中之恰好一者」或當用於申請專利範圍中時「由……組成」將指包括元素之數目或清單中之恰好一個元素。一般而言,當置於排他性術語,諸如「任一」、「中之一者」、「中之僅一者」或「中之恰好一者」之前時,如本文所用之術語「或」應僅解釋為指示排他性替代方式(亦即「一者或另一者但非二者皆」)。當用於申請專利範圍中時,「基本上由……組成」應具有如其在專利法律領域中所使用之普通含義。
如說明書及申請專利範圍中所用,片語「至少一個」在提及一或多個元素之清單時,應該理解為意謂選自元素清單之任一或多個元素中的至少一個元素,但不一定包括元素清單內具體所列之每一個元素中之至少一者且不排除元素清單中之任何元素組合。此定義亦允許可視情況存在除片語「至少一個」所指的該系列要素內具體識別之要素以外的要素,而無論與具體識別之彼等要素相關抑或不相關。由此,作為非限制性實例,「至少一個A及B」(或等效地「至少一個A或B」,或等效地「至少一個A及/或B」)可在一個實施例中指至少一個(視情況包括超過一個)A而不存在B (且視情況包括除B以外的要素);在另一實施例中,指至少一個(視情況包括超過一個)B而不存在A (且視情況包括除A以外的要素);在又一實施例中,指至少一個(視情況包括超過一個) A及至少一個(視情況包括超過一個) B (且視情況包括其他要素);等。
亦應理解,除非截然相反地指示,否則在本文所主張之包括超過一個步驟或操作之任何方法中,該方法之步驟或操作之次序無需侷限於敍述該方法之步驟或操作之順序。
在申請專利範圍中以及在上述說明書中,諸如「包含」、「包括」、「攜載」、「具有」、「含有」、「涉及」、「擁有」、「由……構成」及其類似者之全部過渡性片語應理解為開放的,亦即,意謂包括但不限於。僅過渡片語「由…組成」及「基本上由…組成」應分別為封閉或半封閉過渡片語,如美國專利局專利審查程序手冊(United States Patent Office Manual of Patent Examining Procedures)第2111.03節中所述。應瞭解,在替代實施例中,亦涵蓋此文件中使用開放式過渡片語(例如「包含」)描述之實施例,如「由……組成」及「基本上由……組成」由開放式過渡片語描述之特點。舉例而言,若本發明描述「包含A及B之組合物」,則本發明亦涵蓋替代實施例「由A及B組成之組合物」及「基本上由A及B組成之組合物」。
100:流程 102:信號讀出/信號跡線 200:Φ29聚合酶 202:覆蓋圖 204:多肽結構 500:全透視圖 502:放大透視圖 504:同源性比對 506:環同源性比對 602:突變嵌合聚合酶 604:突變嵌合聚合酶 606:突變嵌合聚合酶 ①:N端外切核酸酶域 ②:掌型子域 ③:TPR1子域 ④:手指型子域 ⑤:TPR2子域 ⑥:拇指型子域
熟習此項技術者將理解本文所描述之圖式僅出於說明之目的。應理解,在一些情況下,為輔助理解本發明,本發明之各種態樣可能經放大或擴大展示。在圖式中,在通篇各種圖中,相同參考標號一般係指相同特點、功能上類似及/或結構上類似之元素。圖式未必為按比例的,實際上重點在於說明教示內容之原理。圖式不意欲以任何方式限制本教示內容之範疇。 本發明之特點及優勢將自下文結合圖式所述之實施方式而變得更顯而易見。 當參考圖式描述實施例時,可使用方向參考(「之上」、「之下」、「頂部」、「底部」、「左側」、「右側」、「水平」、「垂直」等)。此類參考僅意欲作為讀者在正常定向上觀看圖式之輔助。此等方向參考不意欲描述實施裝置之較佳或唯一定向。裝置可以其他定向實施。 如根據詳細描述顯而易知,在本申請案通篇中,圖中描繪且出於說明目的進一步描述之實例描述非限制性實施例,且在一些情況下出於更清楚說明之目的可以簡化某些方法或省略特點或步驟。 1 係說明監測單分子方法之非限制性方法中與信號讀出相關之聚合反應進程的示意圖。 2 係描繪Φ29聚合酶及該聚合酶之域及子域之結構的非限制性說明。 3 描繪所選擇之具有在多肽股之域及子域中之突變位點的突變變異體的非限制性實例。 4 描繪所選擇之具有經取代至多肽股中之不同域及子域之嵌合聚合酶變異體的非限制性實例。 5A 係描繪Φ29聚合酶之外切核酸酶域中之環區域的非限制性說明。 5B 描繪Φ29聚合酶之外切核酸酶區域與非限制性的一組其他聚合酶之間的序列同源性比對。 6 描繪包含一或多個定點突變之嵌合聚合酶變異體之非限制性通用實例。 7 係經實施以評估在大腸桿菌(E. coli)中表現之聚合酶之純度之SDS-PAGE的圖片。 8A-8D 展示來自用屎腸球菌聚合酶變異體、EFM37、EFM48及EFM66進行之DNA合成實驗的結果。圖8A描繪負載有EFM37啞鈴三元複合物之定序晶片。圖8B說明即時停流股置換DNA合成分析。圖8C展示針對不同變異體測定之DNA合成速率。圖8D展示針對不同變異體測定之幅度。 9A-9B 展示野生型屎腸球菌聚合酶之結構表徵。圖9A展示野生型屎腸球菌聚合酶之建模表面。圖9B展示映射至野生型屎腸球菌多肽之聚合酶同源域。 10A-10F 展示來自用基於EFM37親本研發之屎腸球菌聚合酶變異體進行之DNA合成實驗的結果。圖10A展示在用dN6P類似物及含有雙螺旋DNA連接子之類似物(「Q24」)進行之停流股置換合成分析中針對不同變異體所測定之DNA合成速率。圖10B為展示野生型及變異體聚合酶中帶負電及帶正電殘基之數目的圖。圖10C描繪野生型及變異體聚合酶之建模靜電表面。圖10D-10E展示在用Q24進行之停流股置換合成分析中,用25 mM相對於10 mM MgCl2實現的改良之EFM89速率(圖10D)及幅度(圖10E)。圖10F展示在30℃及25 mM MgCl2情況下,在針對野生型EF、EF exo-及EFM89之停流股置換合成分析中使用dNTP的DNA合成之幅度。 11 展示使用EFM89及M13 ssDNA質體模板自定序反應獲得之例示性定序比對。 12A-12D 展示來自商業平台上的用兩個獨立的EFM89製備物進行之DNA定序反應的結果。圖12A報告各種輸出量測值。圖12B展示指示利用EFM89之插入、缺失及錯配誤差之分佈的盒狀圖,其中平均值在上文各盒狀圖指示出。圖12C展示EFM89 (批次1)之總讀段長度之直方圖。圖12D展示EFM89 (批次1)之亞讀段精確度之直方圖。 13A-13B 展示序列比對結果。圖13A展示四種天然存在屎腸球菌聚合酶變異體之間的序列一致性。圖13B展示變異體之間共有的序列一致性。序列藉由其NCBI蛋白質資料庫寄存編號列出。 14A-14B 展示屎腸球菌聚合酶與Φ29之比較。圖14A展示屎腸球菌聚合酶及Φ29之N端之胺基酸序列比對。圖14B展示屎腸球菌聚合酶與Φ29手指型子域(頂部)及掌型子域(底部)之晶體結構比較。Φ29在掌型域中具有延長結構,其可包括於屎腸球菌聚合酶中,例如以提供與核苷酸類似物之有利相互作用(例如dN6P利用率),且用以提供當結合核苷酸類似物時更接近於手指型域之結構特點。 15 展示相對於Φ29之屎腸球菌聚合酶之域組織,其中指示各域之起始位置。 16 係經實施以評估所指示聚合酶之純度之SDS-PAGE的圖片。 17 展示屎腸球菌聚合酶及十七個同源聚合酶之序列的胺基酸序列比對。自頂部至底部之序列為:WP_060797276.1 (SEQ ID NO: 2);NP_690635.1 (SEQ ID NO: 828);YP_002004529.1 (SEQ ID NO: 829);KNC25437.1 (SEQ ID NO: 830);NP_073685.1 (SEQ ID NO: 10);ARM70154.1 (SEQ ID NO: 22);ARQ95230.1 (SEQ ID NO: 831);QDH50332.1 (SEQ ID NO: 832);HMB70020.1 (SEQ ID NO: 833);YP_009198012.1 (SEQ ID NO: 9);WP_077841611.1 (SEQ ID NO: 834);PWM80583.1 (SEQ ID NO: 835);PWM70763.1 (SEQ ID NO: 836);YP_001333659.1 (SEQ ID NO: 11);KKP77830.1 (SEQ ID NO: 12);AYQ98978.1 (SEQ ID NO: 837);AYQ99922.1 (SEQ ID NO: 838);及AXF52067.1 (SEQ ID NO: 839)。突出顯示各種位置(用星號),包括E60 (取代L)、E139 (取代K、Q、T、A、V)及D167 (取代P、K、S、Q、A)。 18 展示相比於Φ29聚合酶中之相同區域,野生型屎腸球菌聚合酶之內部晶體結構中周圍殘基60的區域。 19 展示來自用EFM89及EFM158製備物進行之DNA定序反應的結果。 20 展示使用EFM89聚合酶(左)及EFM158聚合酶(右)達成之讀段長度。 21 展示野生型屎腸球菌聚合酶與EFM158之晶體結構比較,包括活性位點(左)之視圖及演進型變異體(右)之表面之視圖。 22A-22C 展示在位置I148 (圖22A)、E482 (圖22B)及D492 (圖22C)處引入帶正電胺基酸的情況下脈衝間持續時間減少。針對一對僅在所提及之序列處不同之屎腸球菌聚合酶變異體顯示來自單分子DNA定序之脈衝間持續時間。脈衝間持續時間分別對於I148K、E482K及D492H減少21.3%、5.8%及22.6%。 23 展示改良單分子DNA定序中之比對精確度的單取代及組合。變異序列識別符列於圓括號中。除了在所提及之位置以外,所有變異體均具有等效於EFM182之胺基酸序列。取代係相對於EFM182書寫。 24 展示來自評定EF聚合酶持續效力之滾環分析的結果,該等分析在30℃下用具有dNTP (左)及dN6P類似物(右)之90-聚體啞鈴DNA模板進行30分鐘。關於已知之前進型聚合酶QTDE1.0之結果作為參考展示。 25 展示富集於用屎腸球菌聚合酶進行之基於乳劑之IVTT-RCA篩選中的取代。
 
Figure 12_A0101_SEQ_0001
Figure 12_A0101_SEQ_0002
Figure 12_A0101_SEQ_0003
Figure 12_A0101_SEQ_0004
Figure 12_A0101_SEQ_0005
Figure 12_A0101_SEQ_0006
Figure 12_A0101_SEQ_0007
Figure 12_A0101_SEQ_0008
Figure 12_A0101_SEQ_0009
Figure 12_A0101_SEQ_0010
Figure 12_A0101_SEQ_0011
Figure 12_A0101_SEQ_0012
Figure 12_A0101_SEQ_0013
Figure 12_A0101_SEQ_0014
Figure 12_A0101_SEQ_0015
Figure 12_A0101_SEQ_0016
Figure 12_A0101_SEQ_0017
Figure 12_A0101_SEQ_0018
Figure 12_A0101_SEQ_0019
Figure 12_A0101_SEQ_0020
Figure 12_A0101_SEQ_0021
Figure 12_A0101_SEQ_0022
Figure 12_A0101_SEQ_0023
Figure 12_A0101_SEQ_0024
Figure 12_A0101_SEQ_0025
Figure 12_A0101_SEQ_0026
Figure 12_A0101_SEQ_0027
Figure 12_A0101_SEQ_0028
Figure 12_A0101_SEQ_0029
Figure 12_A0101_SEQ_0030
Figure 12_A0101_SEQ_0031
Figure 12_A0101_SEQ_0032
Figure 12_A0101_SEQ_0033
Figure 12_A0101_SEQ_0034
Figure 12_A0101_SEQ_0035
Figure 12_A0101_SEQ_0036
Figure 12_A0101_SEQ_0037
Figure 12_A0101_SEQ_0038
Figure 12_A0101_SEQ_0039
Figure 12_A0101_SEQ_0040
Figure 12_A0101_SEQ_0041
Figure 12_A0101_SEQ_0042
Figure 12_A0101_SEQ_0043
Figure 12_A0101_SEQ_0044
Figure 12_A0101_SEQ_0045
Figure 12_A0101_SEQ_0046
Figure 12_A0101_SEQ_0047
Figure 12_A0101_SEQ_0048
Figure 12_A0101_SEQ_0049
Figure 12_A0101_SEQ_0050
Figure 12_A0101_SEQ_0051
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Figure 12_A0101_SEQ_0053
Figure 12_A0101_SEQ_0054
Figure 12_A0101_SEQ_0055
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Figure 12_A0101_SEQ_0057
Figure 12_A0101_SEQ_0058
Figure 12_A0101_SEQ_0059
Figure 12_A0101_SEQ_0060
Figure 12_A0101_SEQ_0061
Figure 12_A0101_SEQ_0062
Figure 12_A0101_SEQ_0063
Figure 12_A0101_SEQ_0064
Figure 12_A0101_SEQ_0065
Figure 12_A0101_SEQ_0066
Figure 12_A0101_SEQ_0067
Figure 12_A0101_SEQ_0068
Figure 12_A0101_SEQ_0069
Figure 12_A0101_SEQ_0070
Figure 12_A0101_SEQ_0071
Figure 12_A0101_SEQ_0072
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Figure 12_A0101_SEQ_0074
Figure 12_A0101_SEQ_0075
Figure 12_A0101_SEQ_0076
Figure 12_A0101_SEQ_0077
Figure 12_A0101_SEQ_0078
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Figure 12_A0101_SEQ_0080
Figure 12_A0101_SEQ_0081
Figure 12_A0101_SEQ_0082
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Figure 12_A0101_SEQ_0090
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Figure 12_A0101_SEQ_0133
Figure 12_A0101_SEQ_0134
Figure 12_A0101_SEQ_0135
Figure 12_A0101_SEQ_0136
Figure 12_A0101_SEQ_0137
Figure 12_A0101_SEQ_0138
Figure 12_A0101_SEQ_0139
Figure 12_A0101_SEQ_0140
Figure 12_A0101_SEQ_0141
Figure 12_A0101_SEQ_0142
Figure 12_A0101_SEQ_0143
Figure 12_A0101_SEQ_0144
Figure 12_A0101_SEQ_0145
Figure 12_A0101_SEQ_0146
Figure 12_A0101_SEQ_0147
Figure 12_A0101_SEQ_0148
Figure 12_A0101_SEQ_0149
Figure 12_A0101_SEQ_0150
Figure 12_A0101_SEQ_0151
Figure 12_A0101_SEQ_0152
Figure 12_A0101_SEQ_0153
Figure 12_A0101_SEQ_0154
Figure 12_A0101_SEQ_0155
Figure 12_A0101_SEQ_0156
Figure 12_A0101_SEQ_0157
Figure 12_A0101_SEQ_0158
Figure 12_A0101_SEQ_0159
Figure 12_A0101_SEQ_0160
Figure 12_A0101_SEQ_0161
Figure 12_A0101_SEQ_0162
Figure 12_A0101_SEQ_0163
Figure 12_A0101_SEQ_0164
Figure 12_A0101_SEQ_0165
Figure 12_A0101_SEQ_0166
Figure 12_A0101_SEQ_0167
Figure 12_A0101_SEQ_0168
Figure 12_A0101_SEQ_0169
Figure 12_A0101_SEQ_0170
Figure 12_A0101_SEQ_0171
Figure 12_A0101_SEQ_0172
Figure 12_A0101_SEQ_0173
Figure 12_A0101_SEQ_0174
Figure 12_A0101_SEQ_0175
Figure 12_A0101_SEQ_0176
Figure 12_A0101_SEQ_0177
Figure 12_A0101_SEQ_0178
Figure 12_A0101_SEQ_0179
Figure 12_A0101_SEQ_0180
Figure 12_A0101_SEQ_0181
Figure 12_A0101_SEQ_0182
Figure 12_A0101_SEQ_0183
Figure 12_A0101_SEQ_0184
Figure 12_A0101_SEQ_0185
Figure 12_A0101_SEQ_0186
Figure 12_A0101_SEQ_0187
Figure 12_A0101_SEQ_0188
Figure 12_A0101_SEQ_0189
Figure 12_A0101_SEQ_0190
Figure 12_A0101_SEQ_0191
Figure 12_A0101_SEQ_0192
Figure 12_A0101_SEQ_0193
Figure 12_A0101_SEQ_0194
Figure 12_A0101_SEQ_0195
Figure 12_A0101_SEQ_0196
Figure 12_A0101_SEQ_0197
Figure 12_A0101_SEQ_0198
Figure 12_A0101_SEQ_0199
Figure 12_A0101_SEQ_0200
Figure 12_A0101_SEQ_0201
Figure 12_A0101_SEQ_0202
Figure 12_A0101_SEQ_0203
Figure 12_A0101_SEQ_0204
Figure 12_A0101_SEQ_0205
Figure 12_A0101_SEQ_0206
Figure 12_A0101_SEQ_0207
Figure 12_A0101_SEQ_0208
Figure 12_A0101_SEQ_0209
Figure 12_A0101_SEQ_0210
Figure 12_A0101_SEQ_0211
Figure 12_A0101_SEQ_0212
Figure 12_A0101_SEQ_0213
Figure 12_A0101_SEQ_0214
Figure 12_A0101_SEQ_0215
Figure 12_A0101_SEQ_0216
Figure 12_A0101_SEQ_0217
Figure 12_A0101_SEQ_0218
Figure 12_A0101_SEQ_0219
Figure 12_A0101_SEQ_0220
Figure 12_A0101_SEQ_0221
Figure 12_A0101_SEQ_0222
Figure 12_A0101_SEQ_0223
Figure 12_A0101_SEQ_0224
Figure 12_A0101_SEQ_0225
Figure 12_A0101_SEQ_0226
Figure 12_A0101_SEQ_0227
Figure 12_A0101_SEQ_0228
Figure 12_A0101_SEQ_0229
Figure 12_A0101_SEQ_0230
Figure 12_A0101_SEQ_0231
Figure 12_A0101_SEQ_0232
Figure 12_A0101_SEQ_0233
Figure 12_A0101_SEQ_0234
Figure 12_A0101_SEQ_0235
Figure 12_A0101_SEQ_0236
Figure 12_A0101_SEQ_0237
Figure 12_A0101_SEQ_0238
Figure 12_A0101_SEQ_0239
Figure 12_A0101_SEQ_0240
Figure 12_A0101_SEQ_0241
Figure 12_A0101_SEQ_0242
Figure 12_A0101_SEQ_0243
Figure 12_A0101_SEQ_0244
Figure 12_A0101_SEQ_0245
Figure 12_A0101_SEQ_0246
Figure 12_A0101_SEQ_0247
Figure 12_A0101_SEQ_0248
Figure 12_A0101_SEQ_0249
Figure 12_A0101_SEQ_0250
Figure 12_A0101_SEQ_0251
Figure 12_A0101_SEQ_0252
Figure 12_A0101_SEQ_0253
Figure 12_A0101_SEQ_0254
Figure 12_A0101_SEQ_0255
Figure 12_A0101_SEQ_0256
Figure 12_A0101_SEQ_0257
Figure 12_A0101_SEQ_0258
Figure 12_A0101_SEQ_0259
Figure 12_A0101_SEQ_0260
Figure 12_A0101_SEQ_0261
Figure 12_A0101_SEQ_0262
Figure 12_A0101_SEQ_0263
Figure 12_A0101_SEQ_0264
Figure 12_A0101_SEQ_0265
Figure 12_A0101_SEQ_0266
Figure 12_A0101_SEQ_0267
Figure 12_A0101_SEQ_0268
Figure 12_A0101_SEQ_0269
Figure 12_A0101_SEQ_0270
Figure 12_A0101_SEQ_0271
Figure 12_A0101_SEQ_0272
Figure 12_A0101_SEQ_0273
Figure 12_A0101_SEQ_0274
Figure 12_A0101_SEQ_0275
Figure 12_A0101_SEQ_0276
Figure 12_A0101_SEQ_0277
Figure 12_A0101_SEQ_0278
Figure 12_A0101_SEQ_0279
Figure 12_A0101_SEQ_0280
Figure 12_A0101_SEQ_0281
Figure 12_A0101_SEQ_0282
Figure 12_A0101_SEQ_0283
Figure 12_A0101_SEQ_0284
Figure 12_A0101_SEQ_0285
Figure 12_A0101_SEQ_0286
Figure 12_A0101_SEQ_0287
Figure 12_A0101_SEQ_0288
Figure 12_A0101_SEQ_0289
Figure 12_A0101_SEQ_0290
Figure 12_A0101_SEQ_0291
Figure 12_A0101_SEQ_0292
Figure 12_A0101_SEQ_0293
Figure 12_A0101_SEQ_0294
Figure 12_A0101_SEQ_0295
Figure 12_A0101_SEQ_0296
Figure 12_A0101_SEQ_0297
Figure 12_A0101_SEQ_0298
Figure 12_A0101_SEQ_0299
Figure 12_A0101_SEQ_0300
Figure 12_A0101_SEQ_0301
Figure 12_A0101_SEQ_0302
Figure 12_A0101_SEQ_0303
Figure 12_A0101_SEQ_0304
Figure 12_A0101_SEQ_0305
Figure 12_A0101_SEQ_0306
Figure 12_A0101_SEQ_0307
Figure 12_A0101_SEQ_0308
Figure 12_A0101_SEQ_0309
Figure 12_A0101_SEQ_0310
Figure 12_A0101_SEQ_0311
Figure 12_A0101_SEQ_0312
Figure 12_A0101_SEQ_0313
Figure 12_A0101_SEQ_0314
Figure 12_A0101_SEQ_0315
Figure 12_A0101_SEQ_0316
Figure 12_A0101_SEQ_0317
Figure 12_A0101_SEQ_0318
Figure 12_A0101_SEQ_0319
Figure 12_A0101_SEQ_0320
Figure 12_A0101_SEQ_0321
Figure 12_A0101_SEQ_0322
Figure 12_A0101_SEQ_0323
Figure 12_A0101_SEQ_0324
Figure 12_A0101_SEQ_0325
Figure 12_A0101_SEQ_0326
Figure 12_A0101_SEQ_0327
Figure 12_A0101_SEQ_0328
Figure 12_A0101_SEQ_0329
Figure 12_A0101_SEQ_0330
Figure 12_A0101_SEQ_0331
Figure 12_A0101_SEQ_0332
Figure 12_A0101_SEQ_0333
Figure 12_A0101_SEQ_0334
Figure 12_A0101_SEQ_0335
Figure 12_A0101_SEQ_0336
Figure 12_A0101_SEQ_0337
Figure 12_A0101_SEQ_0338
Figure 12_A0101_SEQ_0339
Figure 12_A0101_SEQ_0340
Figure 12_A0101_SEQ_0341
Figure 12_A0101_SEQ_0342
Figure 12_A0101_SEQ_0343
Figure 12_A0101_SEQ_0344
Figure 12_A0101_SEQ_0345
Figure 12_A0101_SEQ_0346
Figure 12_A0101_SEQ_0347
Figure 12_A0101_SEQ_0348
Figure 12_A0101_SEQ_0349
Figure 12_A0101_SEQ_0350
Figure 12_A0101_SEQ_0351
Figure 12_A0101_SEQ_0352
Figure 12_A0101_SEQ_0353
Figure 12_A0101_SEQ_0354
Figure 12_A0101_SEQ_0355
Figure 12_A0101_SEQ_0356
Figure 12_A0101_SEQ_0357
Figure 12_A0101_SEQ_0358
Figure 12_A0101_SEQ_0359
Figure 12_A0101_SEQ_0360
Figure 12_A0101_SEQ_0361
Figure 12_A0101_SEQ_0362
Figure 12_A0101_SEQ_0363
Figure 12_A0101_SEQ_0364
Figure 12_A0101_SEQ_0365
Figure 12_A0101_SEQ_0366
Figure 12_A0101_SEQ_0367
Figure 12_A0101_SEQ_0368
Figure 12_A0101_SEQ_0369
Figure 12_A0101_SEQ_0370
Figure 12_A0101_SEQ_0371
Figure 12_A0101_SEQ_0372
Figure 12_A0101_SEQ_0373
Figure 12_A0101_SEQ_0374
Figure 12_A0101_SEQ_0375
Figure 12_A0101_SEQ_0376
Figure 12_A0101_SEQ_0377
Figure 12_A0101_SEQ_0378
Figure 12_A0101_SEQ_0379
Figure 12_A0101_SEQ_0380
Figure 12_A0101_SEQ_0381
Figure 12_A0101_SEQ_0382
Figure 12_A0101_SEQ_0383
Figure 12_A0101_SEQ_0384
Figure 12_A0101_SEQ_0385
Figure 12_A0101_SEQ_0386
Figure 12_A0101_SEQ_0387
Figure 12_A0101_SEQ_0388
Figure 12_A0101_SEQ_0389
Figure 12_A0101_SEQ_0390
Figure 12_A0101_SEQ_0391
Figure 12_A0101_SEQ_0392
Figure 12_A0101_SEQ_0393
Figure 12_A0101_SEQ_0394
Figure 12_A0101_SEQ_0395
Figure 12_A0101_SEQ_0396
Figure 12_A0101_SEQ_0397
Figure 12_A0101_SEQ_0398
Figure 12_A0101_SEQ_0399
Figure 12_A0101_SEQ_0400
Figure 12_A0101_SEQ_0401
Figure 12_A0101_SEQ_0402
Figure 12_A0101_SEQ_0403
Figure 12_A0101_SEQ_0404
Figure 12_A0101_SEQ_0405
Figure 12_A0101_SEQ_0406
Figure 12_A0101_SEQ_0407
Figure 12_A0101_SEQ_0408
Figure 12_A0101_SEQ_0409
Figure 12_A0101_SEQ_0410
Figure 12_A0101_SEQ_0411
Figure 12_A0101_SEQ_0412
Figure 12_A0101_SEQ_0413
Figure 12_A0101_SEQ_0414
Figure 12_A0101_SEQ_0415
Figure 12_A0101_SEQ_0416
Figure 12_A0101_SEQ_0417
Figure 12_A0101_SEQ_0418
Figure 12_A0101_SEQ_0419
Figure 12_A0101_SEQ_0420
Figure 12_A0101_SEQ_0421
Figure 12_A0101_SEQ_0422
Figure 12_A0101_SEQ_0423
Figure 12_A0101_SEQ_0424
Figure 12_A0101_SEQ_0425
Figure 12_A0101_SEQ_0426
Figure 12_A0101_SEQ_0427
Figure 12_A0101_SEQ_0428
Figure 12_A0101_SEQ_0429
Figure 12_A0101_SEQ_0430
Figure 12_A0101_SEQ_0431
Figure 12_A0101_SEQ_0432
Figure 12_A0101_SEQ_0433
Figure 12_A0101_SEQ_0434
Figure 12_A0101_SEQ_0435
Figure 12_A0101_SEQ_0436
Figure 12_A0101_SEQ_0437
Figure 12_A0101_SEQ_0438
Figure 12_A0101_SEQ_0439
Figure 12_A0101_SEQ_0440
Figure 12_A0101_SEQ_0441
Figure 12_A0101_SEQ_0442
Figure 12_A0101_SEQ_0443
Figure 12_A0101_SEQ_0444
Figure 12_A0101_SEQ_0445
Figure 12_A0101_SEQ_0446
Figure 12_A0101_SEQ_0447
Figure 12_A0101_SEQ_0448
Figure 12_A0101_SEQ_0449
Figure 12_A0101_SEQ_0450
Figure 12_A0101_SEQ_0451
Figure 12_A0101_SEQ_0452
Figure 12_A0101_SEQ_0453
Figure 12_A0101_SEQ_0454
Figure 12_A0101_SEQ_0455
Figure 12_A0101_SEQ_0456
Figure 12_A0101_SEQ_0457
Figure 12_A0101_SEQ_0458
Figure 12_A0101_SEQ_0459
Figure 12_A0101_SEQ_0460
Figure 12_A0101_SEQ_0461
Figure 12_A0101_SEQ_0462
Figure 12_A0101_SEQ_0463
Figure 12_A0101_SEQ_0464
Figure 12_A0101_SEQ_0465
Figure 12_A0101_SEQ_0466
Figure 12_A0101_SEQ_0467
Figure 12_A0101_SEQ_0468
Figure 12_A0101_SEQ_0469
Figure 12_A0101_SEQ_0470
Figure 12_A0101_SEQ_0471
Figure 12_A0101_SEQ_0472
Figure 12_A0101_SEQ_0473
Figure 12_A0101_SEQ_0474
Figure 12_A0101_SEQ_0475
Figure 12_A0101_SEQ_0476
Figure 12_A0101_SEQ_0477
Figure 12_A0101_SEQ_0478
Figure 12_A0101_SEQ_0479
Figure 12_A0101_SEQ_0480
Figure 12_A0101_SEQ_0481
Figure 12_A0101_SEQ_0482
Figure 12_A0101_SEQ_0483
Figure 12_A0101_SEQ_0484
Figure 12_A0101_SEQ_0485
Figure 12_A0101_SEQ_0486
Figure 12_A0101_SEQ_0487
Figure 12_A0101_SEQ_0488
Figure 12_A0101_SEQ_0489
Figure 12_A0101_SEQ_0490
Figure 12_A0101_SEQ_0491
Figure 12_A0101_SEQ_0492
Figure 12_A0101_SEQ_0493
Figure 12_A0101_SEQ_0494
Figure 12_A0101_SEQ_0495
Figure 12_A0101_SEQ_0496
Figure 12_A0101_SEQ_0497
Figure 12_A0101_SEQ_0498
Figure 12_A0101_SEQ_0499
Figure 12_A0101_SEQ_0500
Figure 12_A0101_SEQ_0501
Figure 12_A0101_SEQ_0502
Figure 12_A0101_SEQ_0503
Figure 12_A0101_SEQ_0504
Figure 12_A0101_SEQ_0505
Figure 12_A0101_SEQ_0506
Figure 12_A0101_SEQ_0507
Figure 12_A0101_SEQ_0508
Figure 12_A0101_SEQ_0509
Figure 12_A0101_SEQ_0510
Figure 12_A0101_SEQ_0511
Figure 12_A0101_SEQ_0512
Figure 12_A0101_SEQ_0513
Figure 12_A0101_SEQ_0514
Figure 12_A0101_SEQ_0515
Figure 12_A0101_SEQ_0516
Figure 12_A0101_SEQ_0517
Figure 12_A0101_SEQ_0518
Figure 12_A0101_SEQ_0519
Figure 12_A0101_SEQ_0520
Figure 12_A0101_SEQ_0521
Figure 12_A0101_SEQ_0522
Figure 12_A0101_SEQ_0523
Figure 12_A0101_SEQ_0524
Figure 12_A0101_SEQ_0525
Figure 12_A0101_SEQ_0526
Figure 12_A0101_SEQ_0527
Figure 12_A0101_SEQ_0528
Figure 12_A0101_SEQ_0529
Figure 12_A0101_SEQ_0530
Figure 12_A0101_SEQ_0531
Figure 12_A0101_SEQ_0532
Figure 12_A0101_SEQ_0533
Figure 12_A0101_SEQ_0534
Figure 12_A0101_SEQ_0535
Figure 12_A0101_SEQ_0536
Figure 12_A0101_SEQ_0537
Figure 12_A0101_SEQ_0538
Figure 12_A0101_SEQ_0539
Figure 12_A0101_SEQ_0540
Figure 12_A0101_SEQ_0541
Figure 12_A0101_SEQ_0542
Figure 12_A0101_SEQ_0543
Figure 12_A0101_SEQ_0544
Figure 12_A0101_SEQ_0545
Figure 12_A0101_SEQ_0546
Figure 12_A0101_SEQ_0547
Figure 12_A0101_SEQ_0548
Figure 12_A0101_SEQ_0549
Figure 12_A0101_SEQ_0550
Figure 12_A0101_SEQ_0551
Figure 12_A0101_SEQ_0552
Figure 12_A0101_SEQ_0553
Figure 12_A0101_SEQ_0554
Figure 12_A0101_SEQ_0555
Figure 12_A0101_SEQ_0556
Figure 12_A0101_SEQ_0557
Figure 12_A0101_SEQ_0558
Figure 12_A0101_SEQ_0559
Figure 12_A0101_SEQ_0560
Figure 12_A0101_SEQ_0561
Figure 12_A0101_SEQ_0562
Figure 12_A0101_SEQ_0563
Figure 12_A0101_SEQ_0564
Figure 12_A0101_SEQ_0565
Figure 12_A0101_SEQ_0566
Figure 12_A0101_SEQ_0567
Figure 12_A0101_SEQ_0568
Figure 12_A0101_SEQ_0569
Figure 12_A0101_SEQ_0570
Figure 12_A0101_SEQ_0571
Figure 12_A0101_SEQ_0572
Figure 12_A0101_SEQ_0573
Figure 12_A0101_SEQ_0574
Figure 12_A0101_SEQ_0575
Figure 12_A0101_SEQ_0576
Figure 12_A0101_SEQ_0577
Figure 12_A0101_SEQ_0578
Figure 12_A0101_SEQ_0579
Figure 12_A0101_SEQ_0580
Figure 12_A0101_SEQ_0581
Figure 12_A0101_SEQ_0582
Figure 12_A0101_SEQ_0583
Figure 12_A0101_SEQ_0584
Figure 12_A0101_SEQ_0585
Figure 12_A0101_SEQ_0586
Figure 12_A0101_SEQ_0587
Figure 12_A0101_SEQ_0588
Figure 12_A0101_SEQ_0589
Figure 12_A0101_SEQ_0590
Figure 12_A0101_SEQ_0591
Figure 12_A0101_SEQ_0592
Figure 12_A0101_SEQ_0593
Figure 12_A0101_SEQ_0594
Figure 12_A0101_SEQ_0595
Figure 12_A0101_SEQ_0596
Figure 12_A0101_SEQ_0597
Figure 12_A0101_SEQ_0598
Figure 12_A0101_SEQ_0599
Figure 12_A0101_SEQ_0600
Figure 12_A0101_SEQ_0601
Figure 12_A0101_SEQ_0602
Figure 12_A0101_SEQ_0603
Figure 12_A0101_SEQ_0604
Figure 12_A0101_SEQ_0605
Figure 12_A0101_SEQ_0606
Figure 12_A0101_SEQ_0607
Figure 12_A0101_SEQ_0608
Figure 12_A0101_SEQ_0609
Figure 12_A0101_SEQ_0610
Figure 12_A0101_SEQ_0611
Figure 12_A0101_SEQ_0612
Figure 12_A0101_SEQ_0613
Figure 12_A0101_SEQ_0614
Figure 12_A0101_SEQ_0615
Figure 12_A0101_SEQ_0616
Figure 12_A0101_SEQ_0617
Figure 12_A0101_SEQ_0618
Figure 12_A0101_SEQ_0619
Figure 12_A0101_SEQ_0620
Figure 12_A0101_SEQ_0621
Figure 12_A0101_SEQ_0622
Figure 12_A0101_SEQ_0623
Figure 12_A0101_SEQ_0624
Figure 12_A0101_SEQ_0625
Figure 12_A0101_SEQ_0626
Figure 12_A0101_SEQ_0627
Figure 12_A0101_SEQ_0628
Figure 12_A0101_SEQ_0629
Figure 12_A0101_SEQ_0630
Figure 12_A0101_SEQ_0631
Figure 12_A0101_SEQ_0632
Figure 12_A0101_SEQ_0633
Figure 12_A0101_SEQ_0634
Figure 12_A0101_SEQ_0635
Figure 12_A0101_SEQ_0636
Figure 12_A0101_SEQ_0637
Figure 12_A0101_SEQ_0638
Figure 12_A0101_SEQ_0639
Figure 12_A0101_SEQ_0640
Figure 12_A0101_SEQ_0641
Figure 12_A0101_SEQ_0642
Figure 12_A0101_SEQ_0643
Figure 12_A0101_SEQ_0644
Figure 12_A0101_SEQ_0645
Figure 12_A0101_SEQ_0646
Figure 12_A0101_SEQ_0647
Figure 12_A0101_SEQ_0648
Figure 12_A0101_SEQ_0649
Figure 12_A0101_SEQ_0650
Figure 12_A0101_SEQ_0651
Figure 12_A0101_SEQ_0652
Figure 12_A0101_SEQ_0653
Figure 12_A0101_SEQ_0654
Figure 12_A0101_SEQ_0655
Figure 12_A0101_SEQ_0656
Figure 12_A0101_SEQ_0657
Figure 12_A0101_SEQ_0658
Figure 12_A0101_SEQ_0659
Figure 12_A0101_SEQ_0660
Figure 12_A0101_SEQ_0661
Figure 12_A0101_SEQ_0662
Figure 12_A0101_SEQ_0663
Figure 12_A0101_SEQ_0664
Figure 12_A0101_SEQ_0665
Figure 12_A0101_SEQ_0666
Figure 12_A0101_SEQ_0667
Figure 12_A0101_SEQ_0668
Figure 12_A0101_SEQ_0669
Figure 12_A0101_SEQ_0670
Figure 12_A0101_SEQ_0671
Figure 12_A0101_SEQ_0672
Figure 12_A0101_SEQ_0673
Figure 12_A0101_SEQ_0674
Figure 12_A0101_SEQ_0675
Figure 12_A0101_SEQ_0676
Figure 12_A0101_SEQ_0677
Figure 12_A0101_SEQ_0678
Figure 12_A0101_SEQ_0679
Figure 12_A0101_SEQ_0680
Figure 12_A0101_SEQ_0681
Figure 12_A0101_SEQ_0682
Figure 12_A0101_SEQ_0683
Figure 12_A0101_SEQ_0684
Figure 12_A0101_SEQ_0685
Figure 12_A0101_SEQ_0686
Figure 12_A0101_SEQ_0687
Figure 12_A0101_SEQ_0688
Figure 12_A0101_SEQ_0689
Figure 12_A0101_SEQ_0690
Figure 12_A0101_SEQ_0691
Figure 12_A0101_SEQ_0692
Figure 12_A0101_SEQ_0693
Figure 12_A0101_SEQ_0694
Figure 12_A0101_SEQ_0695
Figure 12_A0101_SEQ_0696
Figure 12_A0101_SEQ_0697
Figure 12_A0101_SEQ_0698
Figure 12_A0101_SEQ_0699
Figure 12_A0101_SEQ_0700
Figure 12_A0101_SEQ_0701
Figure 12_A0101_SEQ_0702
Figure 12_A0101_SEQ_0703
Figure 12_A0101_SEQ_0704
Figure 12_A0101_SEQ_0705
Figure 12_A0101_SEQ_0706
Figure 12_A0101_SEQ_0707
Figure 12_A0101_SEQ_0708
Figure 12_A0101_SEQ_0709
Figure 12_A0101_SEQ_0710
Figure 12_A0101_SEQ_0711
Figure 12_A0101_SEQ_0712
Figure 12_A0101_SEQ_0713
Figure 12_A0101_SEQ_0714
Figure 12_A0101_SEQ_0715
Figure 12_A0101_SEQ_0716
Figure 12_A0101_SEQ_0717
Figure 12_A0101_SEQ_0718
Figure 12_A0101_SEQ_0719
Figure 12_A0101_SEQ_0720
Figure 12_A0101_SEQ_0721
Figure 12_A0101_SEQ_0722
Figure 12_A0101_SEQ_0723
Figure 12_A0101_SEQ_0724
Figure 12_A0101_SEQ_0725
Figure 12_A0101_SEQ_0726
Figure 12_A0101_SEQ_0727
Figure 12_A0101_SEQ_0728
Figure 12_A0101_SEQ_0729
Figure 12_A0101_SEQ_0730
Figure 12_A0101_SEQ_0731
Figure 12_A0101_SEQ_0732
Figure 12_A0101_SEQ_0733
Figure 12_A0101_SEQ_0734
Figure 12_A0101_SEQ_0735
Figure 12_A0101_SEQ_0736
Figure 12_A0101_SEQ_0737
Figure 12_A0101_SEQ_0738
Figure 12_A0101_SEQ_0739
Figure 12_A0101_SEQ_0740
Figure 12_A0101_SEQ_0741
Figure 12_A0101_SEQ_0742
Figure 12_A0101_SEQ_0743
Figure 12_A0101_SEQ_0744
Figure 12_A0101_SEQ_0745
Figure 12_A0101_SEQ_0746
Figure 12_A0101_SEQ_0747
Figure 12_A0101_SEQ_0748
Figure 12_A0101_SEQ_0749
Figure 12_A0101_SEQ_0750
Figure 12_A0101_SEQ_0751
Figure 12_A0101_SEQ_0752
Figure 12_A0101_SEQ_0753
Figure 12_A0101_SEQ_0754
Figure 12_A0101_SEQ_0755
Figure 12_A0101_SEQ_0756
Figure 12_A0101_SEQ_0757
Figure 12_A0101_SEQ_0758
Figure 12_A0101_SEQ_0759
Figure 12_A0101_SEQ_0760
Figure 12_A0101_SEQ_0761
Figure 12_A0101_SEQ_0762
Figure 12_A0101_SEQ_0763
Figure 12_A0101_SEQ_0764
Figure 12_A0101_SEQ_0765
Figure 12_A0101_SEQ_0766
Figure 12_A0101_SEQ_0767
Figure 12_A0101_SEQ_0768
Figure 12_A0101_SEQ_0769
Figure 12_A0101_SEQ_0770
Figure 12_A0101_SEQ_0771
Figure 12_A0101_SEQ_0772
Figure 12_A0101_SEQ_0773
Figure 12_A0101_SEQ_0774
Figure 12_A0101_SEQ_0775
Figure 12_A0101_SEQ_0776
Figure 12_A0101_SEQ_0777
Figure 12_A0101_SEQ_0778
Figure 12_A0101_SEQ_0779
Figure 12_A0101_SEQ_0780
Figure 12_A0101_SEQ_0781
Figure 12_A0101_SEQ_0782
Figure 12_A0101_SEQ_0783
Figure 12_A0101_SEQ_0784
Figure 12_A0101_SEQ_0785
Figure 12_A0101_SEQ_0786
Figure 12_A0101_SEQ_0787
Figure 12_A0101_SEQ_0788
Figure 12_A0101_SEQ_0789
Figure 12_A0101_SEQ_0790
Figure 12_A0101_SEQ_0791
Figure 12_A0101_SEQ_0792
Figure 12_A0101_SEQ_0793
Figure 12_A0101_SEQ_0794
Figure 12_A0101_SEQ_0795
Figure 12_A0101_SEQ_0796
Figure 12_A0101_SEQ_0797
Figure 12_A0101_SEQ_0798
Figure 12_A0101_SEQ_0799
Figure 12_A0101_SEQ_0800
Figure 12_A0101_SEQ_0801
Figure 12_A0101_SEQ_0802
Figure 12_A0101_SEQ_0803
Figure 12_A0101_SEQ_0804
Figure 12_A0101_SEQ_0805
Figure 12_A0101_SEQ_0806
Figure 12_A0101_SEQ_0807
Figure 12_A0101_SEQ_0808
Figure 12_A0101_SEQ_0809
Figure 12_A0101_SEQ_0810
Figure 12_A0101_SEQ_0811
Figure 12_A0101_SEQ_0812
Figure 12_A0101_SEQ_0813
Figure 12_A0101_SEQ_0814
Figure 12_A0101_SEQ_0815
Figure 12_A0101_SEQ_0816
Figure 12_A0101_SEQ_0817
Figure 12_A0101_SEQ_0818
Figure 12_A0101_SEQ_0819
Figure 12_A0101_SEQ_0820
Figure 12_A0101_SEQ_0821
Figure 12_A0101_SEQ_0822
Figure 12_A0101_SEQ_0823
Figure 12_A0101_SEQ_0824
Figure 12_A0101_SEQ_0825
Figure 12_A0101_SEQ_0826
Figure 12_A0101_SEQ_0827
Figure 12_A0101_SEQ_0828
Figure 12_A0101_SEQ_0829
Figure 12_A0101_SEQ_0830
Figure 12_A0101_SEQ_0831
Figure 12_A0101_SEQ_0832
Figure 12_A0101_SEQ_0833
Figure 12_A0101_SEQ_0834
Figure 12_A0101_SEQ_0835
Figure 12_A0101_SEQ_0836
Figure 12_A0101_SEQ_0837
Figure 12_A0101_SEQ_0838
Figure 12_A0101_SEQ_0839
Figure 12_A0101_SEQ_0840
Figure 12_A0101_SEQ_0841
Figure 12_A0101_SEQ_0842
Figure 12_A0101_SEQ_0843
Figure 12_A0101_SEQ_0844
Figure 12_A0101_SEQ_0845
Figure 12_A0101_SEQ_0846
Figure 12_A0101_SEQ_0847
Figure 12_A0101_SEQ_0848
Figure 12_A0101_SEQ_0849
Figure 12_A0101_SEQ_0850
Figure 12_A0101_SEQ_0851
Figure 12_A0101_SEQ_0852
Figure 12_A0101_SEQ_0853
Figure 12_A0101_SEQ_0854
Figure 12_A0101_SEQ_0855
Figure 12_A0101_SEQ_0856
Figure 12_A0101_SEQ_0857
Figure 12_A0101_SEQ_0858
Figure 12_A0101_SEQ_0859
Figure 12_A0101_SEQ_0860
Figure 12_A0101_SEQ_0861
Figure 12_A0101_SEQ_0862
Figure 12_A0101_SEQ_0863
Figure 12_A0101_SEQ_0864
Figure 12_A0101_SEQ_0865
Figure 12_A0101_SEQ_0866
Figure 12_A0101_SEQ_0867
Figure 12_A0101_SEQ_0868
Figure 12_A0101_SEQ_0869
Figure 12_A0101_SEQ_0870
Figure 12_A0101_SEQ_0871
Figure 12_A0101_SEQ_0872
Figure 12_A0101_SEQ_0873
Figure 12_A0101_SEQ_0874
Figure 12_A0101_SEQ_0875
Figure 12_A0101_SEQ_0876
Figure 12_A0101_SEQ_0877
Figure 12_A0101_SEQ_0878
Figure 12_A0101_SEQ_0879
Figure 12_A0101_SEQ_0880
Figure 12_A0101_SEQ_0881
Figure 12_A0101_SEQ_0882
Figure 12_A0101_SEQ_0883
Figure 12_A0101_SEQ_0884
Figure 12_A0101_SEQ_0885
Figure 12_A0101_SEQ_0886
Figure 12_A0101_SEQ_0887
Figure 12_A0101_SEQ_0888
Figure 12_A0101_SEQ_0889
Figure 12_A0101_SEQ_0890
Figure 12_A0101_SEQ_0891
Figure 12_A0101_SEQ_0892
Figure 12_A0101_SEQ_0893
Figure 12_A0101_SEQ_0894
Figure 12_A0101_SEQ_0895
Figure 12_A0101_SEQ_0896
Figure 12_A0101_SEQ_0897
Figure 12_A0101_SEQ_0898
Figure 12_A0101_SEQ_0899
Figure 12_A0101_SEQ_0900
Figure 12_A0101_SEQ_0901
Figure 12_A0101_SEQ_0902
Figure 12_A0101_SEQ_0903
Figure 12_A0101_SEQ_0904
Figure 12_A0101_SEQ_0905
Figure 12_A0101_SEQ_0906
Figure 12_A0101_SEQ_0907
Figure 12_A0101_SEQ_0908
Figure 12_A0101_SEQ_0909
Figure 12_A0101_SEQ_0910
Figure 12_A0101_SEQ_0911
Figure 12_A0101_SEQ_0912
Figure 12_A0101_SEQ_0913
Figure 12_A0101_SEQ_0914
Figure 12_A0101_SEQ_0915
Figure 12_A0101_SEQ_0916
Figure 12_A0101_SEQ_0917
Figure 12_A0101_SEQ_0918
Figure 12_A0101_SEQ_0919
Figure 12_A0101_SEQ_0920
Figure 12_A0101_SEQ_0921
Figure 12_A0101_SEQ_0922
Figure 12_A0101_SEQ_0923
Figure 12_A0101_SEQ_0924
Figure 12_A0101_SEQ_0925
Figure 12_A0101_SEQ_0926
Figure 12_A0101_SEQ_0927
Figure 12_A0101_SEQ_0928
Figure 12_A0101_SEQ_0929
Figure 12_A0101_SEQ_0930
Figure 12_A0101_SEQ_0931
Figure 12_A0101_SEQ_0932
Figure 12_A0101_SEQ_0933
Figure 12_A0101_SEQ_0934
Figure 12_A0101_SEQ_0935
Figure 12_A0101_SEQ_0936
Figure 12_A0101_SEQ_0937
Figure 12_A0101_SEQ_0938
Figure 12_A0101_SEQ_0939
Figure 12_A0101_SEQ_0940
Figure 12_A0101_SEQ_0941
Figure 12_A0101_SEQ_0942
Figure 12_A0101_SEQ_0943
Figure 12_A0101_SEQ_0944
Figure 12_A0101_SEQ_0945
Figure 12_A0101_SEQ_0946
Figure 12_A0101_SEQ_0947
Figure 12_A0101_SEQ_0948
Figure 12_A0101_SEQ_0949
Figure 12_A0101_SEQ_0950
Figure 12_A0101_SEQ_0951
Figure 12_A0101_SEQ_0952
Figure 12_A0101_SEQ_0953
Figure 12_A0101_SEQ_0954
Figure 12_A0101_SEQ_0955
Figure 12_A0101_SEQ_0956
Figure 12_A0101_SEQ_0957
Figure 12_A0101_SEQ_0958
Figure 12_A0101_SEQ_0959
Figure 12_A0101_SEQ_0960
Figure 12_A0101_SEQ_0961
Figure 12_A0101_SEQ_0962
Figure 12_A0101_SEQ_0963
Figure 12_A0101_SEQ_0964
Figure 12_A0101_SEQ_0965
Figure 12_A0101_SEQ_0966
Figure 12_A0101_SEQ_0967
Figure 12_A0101_SEQ_0968
Figure 12_A0101_SEQ_0969
Figure 12_A0101_SEQ_0970
Figure 12_A0101_SEQ_0971
Figure 12_A0101_SEQ_0972
Figure 12_A0101_SEQ_0973
Figure 12_A0101_SEQ_0974
Figure 12_A0101_SEQ_0975
Figure 12_A0101_SEQ_0976
Figure 12_A0101_SEQ_0977
Figure 12_A0101_SEQ_0978
Figure 12_A0101_SEQ_0979
Figure 12_A0101_SEQ_0980
Figure 12_A0101_SEQ_0981
Figure 12_A0101_SEQ_0982
Figure 12_A0101_SEQ_0983
Figure 12_A0101_SEQ_0984
Figure 12_A0101_SEQ_0985
Figure 12_A0101_SEQ_0986
Figure 12_A0101_SEQ_0987
Figure 12_A0101_SEQ_0988
Figure 12_A0101_SEQ_0989
Figure 12_A0101_SEQ_0990
Figure 12_A0101_SEQ_0991
Figure 12_A0101_SEQ_0992
Figure 12_A0101_SEQ_0993
Figure 12_A0101_SEQ_0994
Figure 12_A0101_SEQ_0995
Figure 12_A0101_SEQ_0996
Figure 12_A0101_SEQ_0997
Figure 12_A0101_SEQ_0998
Figure 12_A0101_SEQ_0999
Figure 12_A0101_SEQ_1000
Figure 12_A0101_SEQ_1001
Figure 12_A0101_SEQ_1002
Figure 12_A0101_SEQ_1003
Figure 12_A0101_SEQ_1004
Figure 12_A0101_SEQ_1005
Figure 12_A0101_SEQ_1006
Figure 12_A0101_SEQ_1007
Figure 12_A0101_SEQ_1008
Figure 12_A0101_SEQ_1009
Figure 12_A0101_SEQ_1010
Figure 12_A0101_SEQ_1011
Figure 12_A0101_SEQ_1012
Figure 12_A0101_SEQ_1013
Figure 12_A0101_SEQ_1014
Figure 12_A0101_SEQ_1015
Figure 12_A0101_SEQ_1016
Figure 12_A0101_SEQ_1017
Figure 12_A0101_SEQ_1018
Figure 12_A0101_SEQ_1019
Figure 12_A0101_SEQ_1020
Figure 12_A0101_SEQ_1021
Figure 12_A0101_SEQ_1022
Figure 12_A0101_SEQ_1023
Figure 12_A0101_SEQ_1024
Figure 12_A0101_SEQ_1025
Figure 12_A0101_SEQ_1026
Figure 12_A0101_SEQ_1027
Figure 12_A0101_SEQ_1028
Figure 12_A0101_SEQ_1029
Figure 12_A0101_SEQ_1030
Figure 12_A0101_SEQ_1031
Figure 12_A0101_SEQ_1032
Figure 12_A0101_SEQ_1033
Figure 12_A0101_SEQ_1034
Figure 12_A0101_SEQ_1035
Figure 12_A0101_SEQ_1036
Figure 12_A0101_SEQ_1037
Figure 12_A0101_SEQ_1038
Figure 12_A0101_SEQ_1039
Figure 12_A0101_SEQ_1040
Figure 12_A0101_SEQ_1041
Figure 12_A0101_SEQ_1042
Figure 12_A0101_SEQ_1043
Figure 12_A0101_SEQ_1044
Figure 12_A0101_SEQ_1045
Figure 12_A0101_SEQ_1046
Figure 12_A0101_SEQ_1047
Figure 12_A0101_SEQ_1048
Figure 12_A0101_SEQ_1049
Figure 12_A0101_SEQ_1050
Figure 12_A0101_SEQ_1051
Figure 12_A0101_SEQ_1052
Figure 12_A0101_SEQ_1053
Figure 12_A0101_SEQ_1054
Figure 12_A0101_SEQ_1055
Figure 12_A0101_SEQ_1056
Figure 12_A0101_SEQ_1057
Figure 12_A0101_SEQ_1058
Figure 12_A0101_SEQ_1059
Figure 12_A0101_SEQ_1060
Figure 12_A0101_SEQ_1061
Figure 12_A0101_SEQ_1062
Figure 12_A0101_SEQ_1063
Figure 12_A0101_SEQ_1064
Figure 12_A0101_SEQ_1065
Figure 12_A0101_SEQ_1066
Figure 12_A0101_SEQ_1067
Figure 12_A0101_SEQ_1068
Figure 12_A0101_SEQ_1069
Figure 12_A0101_SEQ_1070
Figure 12_A0101_SEQ_1071
Figure 12_A0101_SEQ_1072
Figure 12_A0101_SEQ_1073
Figure 12_A0101_SEQ_1074
Figure 12_A0101_SEQ_1075
Figure 12_A0101_SEQ_1076
Figure 12_A0101_SEQ_1077
Figure 12_A0101_SEQ_1078
Figure 12_A0101_SEQ_1079
Figure 12_A0101_SEQ_1080
Figure 12_A0101_SEQ_1081
Figure 12_A0101_SEQ_1082
Figure 12_A0101_SEQ_1083
Figure 12_A0101_SEQ_1084
Figure 12_A0101_SEQ_1085
Figure 12_A0101_SEQ_1086
Figure 12_A0101_SEQ_1087
Figure 12_A0101_SEQ_1088
Figure 12_A0101_SEQ_1089
Figure 12_A0101_SEQ_1090
Figure 12_A0101_SEQ_1091
Figure 12_A0101_SEQ_1092
Figure 12_A0101_SEQ_1093
Figure 12_A0101_SEQ_1094
Figure 12_A0101_SEQ_1095
Figure 12_A0101_SEQ_1096
Figure 12_A0101_SEQ_1097
Figure 12_A0101_SEQ_1098
Figure 12_A0101_SEQ_1099
Figure 12_A0101_SEQ_1100
Figure 12_A0101_SEQ_1101
Figure 12_A0101_SEQ_1102
Figure 12_A0101_SEQ_1103
Figure 12_A0101_SEQ_1104
Figure 12_A0101_SEQ_1105
Figure 12_A0101_SEQ_1106
Figure 12_A0101_SEQ_1107
Figure 12_A0101_SEQ_1108
Figure 12_A0101_SEQ_1109
Figure 12_A0101_SEQ_1110
Figure 12_A0101_SEQ_1111
Figure 12_A0101_SEQ_1112
Figure 12_A0101_SEQ_1113
Figure 12_A0101_SEQ_1114
Figure 12_A0101_SEQ_1115
Figure 12_A0101_SEQ_1116
Figure 12_A0101_SEQ_1117
Figure 12_A0101_SEQ_1118
Figure 12_A0101_SEQ_1119
Figure 12_A0101_SEQ_1120
Figure 12_A0101_SEQ_1121
Figure 12_A0101_SEQ_1122
Figure 12_A0101_SEQ_1123
Figure 12_A0101_SEQ_1124
Figure 12_A0101_SEQ_1125
Figure 12_A0101_SEQ_1126
Figure 12_A0101_SEQ_1127
Figure 12_A0101_SEQ_1128
Figure 12_A0101_SEQ_1129
Figure 12_A0101_SEQ_1130
Figure 12_A0101_SEQ_1131
Figure 12_A0101_SEQ_1132
Figure 12_A0101_SEQ_1133
Figure 12_A0101_SEQ_1134
Figure 12_A0101_SEQ_1135
Figure 12_A0101_SEQ_1136
Figure 12_A0101_SEQ_1137
Figure 12_A0101_SEQ_1138
Figure 12_A0101_SEQ_1139
Figure 12_A0101_SEQ_1140
Figure 12_A0101_SEQ_1141
Figure 12_A0101_SEQ_1142
Figure 12_A0101_SEQ_1143
Figure 12_A0101_SEQ_1144
Figure 12_A0101_SEQ_1145
Figure 12_A0101_SEQ_1146
Figure 12_A0101_SEQ_1147
Figure 12_A0101_SEQ_1148
Figure 12_A0101_SEQ_1149
Figure 12_A0101_SEQ_1150
Figure 12_A0101_SEQ_1151
Figure 12_A0101_SEQ_1152
Figure 12_A0101_SEQ_1153
Figure 12_A0101_SEQ_1154
Figure 12_A0101_SEQ_1155
Figure 12_A0101_SEQ_1156
Figure 12_A0101_SEQ_1157
Figure 12_A0101_SEQ_1158
Figure 12_A0101_SEQ_1159
Figure 12_A0101_SEQ_1160
Figure 12_A0101_SEQ_1161
Figure 12_A0101_SEQ_1162
Figure 12_A0101_SEQ_1163
Figure 12_A0101_SEQ_1164
Figure 12_A0101_SEQ_1165
Figure 12_A0101_SEQ_1166
Figure 12_A0101_SEQ_1167
Figure 12_A0101_SEQ_1168
Figure 12_A0101_SEQ_1169
Figure 12_A0101_SEQ_1170
Figure 12_A0101_SEQ_1171
Figure 12_A0101_SEQ_1172
Figure 12_A0101_SEQ_1173
Figure 12_A0101_SEQ_1174
Figure 12_A0101_SEQ_1175
Figure 12_A0101_SEQ_1176
Figure 12_A0101_SEQ_1177
Figure 12_A0101_SEQ_1178
Figure 12_A0101_SEQ_1179
Figure 12_A0101_SEQ_1180
Figure 12_A0101_SEQ_1181
Figure 12_A0101_SEQ_1182
Figure 12_A0101_SEQ_1183
Figure 12_A0101_SEQ_1184
Figure 12_A0101_SEQ_1185
Figure 12_A0101_SEQ_1186
Figure 12_A0101_SEQ_1187
Figure 12_A0101_SEQ_1188
Figure 12_A0101_SEQ_1189
Figure 12_A0101_SEQ_1190
Figure 12_A0101_SEQ_1191
Figure 12_A0101_SEQ_1192
Figure 12_A0101_SEQ_1193
Figure 12_A0101_SEQ_1194
Figure 12_A0101_SEQ_1195
Figure 12_A0101_SEQ_1196
Figure 12_A0101_SEQ_1197
Figure 12_A0101_SEQ_1198
Figure 12_A0101_SEQ_1199
Figure 12_A0101_SEQ_1200
Figure 12_A0101_SEQ_1201
Figure 12_A0101_SEQ_1202
Figure 12_A0101_SEQ_1203
Figure 12_A0101_SEQ_1204
Figure 12_A0101_SEQ_1205
Figure 12_A0101_SEQ_1206
Figure 12_A0101_SEQ_1207
Figure 12_A0101_SEQ_1208
Figure 12_A0101_SEQ_1209
Figure 12_A0101_SEQ_1210
Figure 12_A0101_SEQ_1211
Figure 12_A0101_SEQ_1212
Figure 12_A0101_SEQ_1213
Figure 12_A0101_SEQ_1214
Figure 12_A0101_SEQ_1215
Figure 12_A0101_SEQ_1216
Figure 12_A0101_SEQ_1217
Figure 12_A0101_SEQ_1218
Figure 12_A0101_SEQ_1219
Figure 12_A0101_SEQ_1220
Figure 12_A0101_SEQ_1221
Figure 12_A0101_SEQ_1222
Figure 12_A0101_SEQ_1223
Figure 12_A0101_SEQ_1224
Figure 12_A0101_SEQ_1225
Figure 12_A0101_SEQ_1226
Figure 12_A0101_SEQ_1227
Figure 12_A0101_SEQ_1228
Figure 12_A0101_SEQ_1229
Figure 12_A0101_SEQ_1230
Figure 12_A0101_SEQ_1231
Figure 12_A0101_SEQ_1232
Figure 12_A0101_SEQ_1233
Figure 12_A0101_SEQ_1234
Figure 12_A0101_SEQ_1235
Figure 12_A0101_SEQ_1236
Figure 12_A0101_SEQ_1237
Figure 12_A0101_SEQ_1238
Figure 12_A0101_SEQ_1239
Figure 12_A0101_SEQ_1240
Figure 12_A0101_SEQ_1241
Figure 12_A0101_SEQ_1242
Figure 12_A0101_SEQ_1243
Figure 12_A0101_SEQ_1244
Figure 12_A0101_SEQ_1245
Figure 12_A0101_SEQ_1246
Figure 12_A0101_SEQ_1247
Figure 12_A0101_SEQ_1248
Figure 12_A0101_SEQ_1249
Figure 12_A0101_SEQ_1250
Figure 12_A0101_SEQ_1251
Figure 12_A0101_SEQ_1252
Figure 12_A0101_SEQ_1253
Figure 12_A0101_SEQ_1254
Figure 12_A0101_SEQ_1255
Figure 12_A0101_SEQ_1256
Figure 12_A0101_SEQ_1257
Figure 12_A0101_SEQ_1258
Figure 12_A0101_SEQ_1259
Figure 12_A0101_SEQ_1260
Figure 12_A0101_SEQ_1261
Figure 12_A0101_SEQ_1262
Figure 12_A0101_SEQ_1263
Figure 12_A0101_SEQ_1264
Figure 12_A0101_SEQ_1265
Figure 12_A0101_SEQ_1266
Figure 12_A0101_SEQ_1267
Figure 12_A0101_SEQ_1268
Figure 12_A0101_SEQ_1269
Figure 12_A0101_SEQ_1270
Figure 12_A0101_SEQ_1271
Figure 12_A0101_SEQ_1272
Figure 12_A0101_SEQ_1273
Figure 12_A0101_SEQ_1274
Figure 12_A0101_SEQ_1275
Figure 12_A0101_SEQ_1276
Figure 12_A0101_SEQ_1277
Figure 12_A0101_SEQ_1278
Figure 12_A0101_SEQ_1279
Figure 12_A0101_SEQ_1280
Figure 12_A0101_SEQ_1281
Figure 12_A0101_SEQ_1282
Figure 12_A0101_SEQ_1283
Figure 12_A0101_SEQ_1284
Figure 12_A0101_SEQ_1285
Figure 12_A0101_SEQ_1286
Figure 12_A0101_SEQ_1287
Figure 12_A0101_SEQ_1288
Figure 12_A0101_SEQ_1289
Figure 12_A0101_SEQ_1290
Figure 12_A0101_SEQ_1291
Figure 12_A0101_SEQ_1292
Figure 12_A0101_SEQ_1293
Figure 12_A0101_SEQ_1294
Figure 12_A0101_SEQ_1295
Figure 12_A0101_SEQ_1296
Figure 12_A0101_SEQ_1297
Figure 12_A0101_SEQ_1298
Figure 12_A0101_SEQ_1299
Figure 12_A0101_SEQ_1300
Figure 12_A0101_SEQ_1301
Figure 12_A0101_SEQ_1302
Figure 12_A0101_SEQ_1303
Figure 12_A0101_SEQ_1304
Figure 12_A0101_SEQ_1305
Figure 12_A0101_SEQ_1306
Figure 12_A0101_SEQ_1307
Figure 12_A0101_SEQ_1308
Figure 12_A0101_SEQ_1309
Figure 12_A0101_SEQ_1310
Figure 12_A0101_SEQ_1311
Figure 12_A0101_SEQ_1312
Figure 12_A0101_SEQ_1313
Figure 12_A0101_SEQ_1314
Figure 12_A0101_SEQ_1315
Figure 12_A0101_SEQ_1316
Figure 12_A0101_SEQ_1317
Figure 12_A0101_SEQ_1318
Figure 12_A0101_SEQ_1319
Figure 12_A0101_SEQ_1320
Figure 12_A0101_SEQ_1321
Figure 12_A0101_SEQ_1322
Figure 12_A0101_SEQ_1323
Figure 12_A0101_SEQ_1324
Figure 12_A0101_SEQ_1325
Figure 12_A0101_SEQ_1326
Figure 12_A0101_SEQ_1327
Figure 12_A0101_SEQ_1328
Figure 12_A0101_SEQ_1329
Figure 12_A0101_SEQ_1330
Figure 12_A0101_SEQ_1331
Figure 12_A0101_SEQ_1332
Figure 12_A0101_SEQ_1333
Figure 12_A0101_SEQ_1334
Figure 12_A0101_SEQ_1335
Figure 12_A0101_SEQ_1336
Figure 12_A0101_SEQ_1337
Figure 12_A0101_SEQ_1338
Figure 12_A0101_SEQ_1339
Figure 12_A0101_SEQ_1340
Figure 12_A0101_SEQ_1341
Figure 12_A0101_SEQ_1342
Figure 12_A0101_SEQ_1343
Figure 12_A0101_SEQ_1344
Figure 12_A0101_SEQ_1345
Figure 12_A0101_SEQ_1346
Figure 12_A0101_SEQ_1347
Figure 12_A0101_SEQ_1348
Figure 12_A0101_SEQ_1349
Figure 12_A0101_SEQ_1350
Figure 12_A0101_SEQ_1351
Figure 12_A0101_SEQ_1352
Figure 12_A0101_SEQ_1353
Figure 12_A0101_SEQ_1354
Figure 12_A0101_SEQ_1355
Figure 12_A0101_SEQ_1356
Figure 12_A0101_SEQ_1357
Figure 12_A0101_SEQ_1358
Figure 12_A0101_SEQ_1359
Figure 12_A0101_SEQ_1360
Figure 12_A0101_SEQ_1361
Figure 12_A0101_SEQ_1362
Figure 12_A0101_SEQ_1363
Figure 12_A0101_SEQ_1364
Figure 12_A0101_SEQ_1365
Figure 12_A0101_SEQ_1366
Figure 12_A0101_SEQ_1367
Figure 12_A0101_SEQ_1368
Figure 12_A0101_SEQ_1369
Figure 12_A0101_SEQ_1370
Figure 12_A0101_SEQ_1371
Figure 12_A0101_SEQ_1372
Figure 12_A0101_SEQ_1373
Figure 12_A0101_SEQ_1374
Figure 12_A0101_SEQ_1375
Figure 12_A0101_SEQ_1376
Figure 12_A0101_SEQ_1377
Figure 12_A0101_SEQ_1378
Figure 12_A0101_SEQ_1379
Figure 12_A0101_SEQ_1380
Figure 12_A0101_SEQ_1381
Figure 12_A0101_SEQ_1382
Figure 12_A0101_SEQ_1383
Figure 12_A0101_SEQ_1384
Figure 12_A0101_SEQ_1385
Figure 12_A0101_SEQ_1386
Figure 12_A0101_SEQ_1387
Figure 12_A0101_SEQ_1388
Figure 12_A0101_SEQ_1389
Figure 12_A0101_SEQ_1390
Figure 12_A0101_SEQ_1391
Figure 12_A0101_SEQ_1392
Figure 12_A0101_SEQ_1393
Figure 12_A0101_SEQ_1394
Figure 12_A0101_SEQ_1395
Figure 12_A0101_SEQ_1396
Figure 12_A0101_SEQ_1397
Figure 12_A0101_SEQ_1398
Figure 12_A0101_SEQ_1399
Figure 12_A0101_SEQ_1400
Figure 12_A0101_SEQ_1401
Figure 12_A0101_SEQ_1402
Figure 12_A0101_SEQ_1403
Figure 12_A0101_SEQ_1404
Figure 12_A0101_SEQ_1405
Figure 12_A0101_SEQ_1406
Figure 12_A0101_SEQ_1407
Figure 12_A0101_SEQ_1408
Figure 12_A0101_SEQ_1409
Figure 12_A0101_SEQ_1410
Figure 12_A0101_SEQ_1411
Figure 12_A0101_SEQ_1412
Figure 12_A0101_SEQ_1413
Figure 12_A0101_SEQ_1414
Figure 12_A0101_SEQ_1415
Figure 12_A0101_SEQ_1416
Figure 12_A0101_SEQ_1417
Figure 12_A0101_SEQ_1418
Figure 12_A0101_SEQ_1419
Figure 12_A0101_SEQ_1420
Figure 12_A0101_SEQ_1421
Figure 12_A0101_SEQ_1422
Figure 12_A0101_SEQ_1423
Figure 12_A0101_SEQ_1424
Figure 12_A0101_SEQ_1425
Figure 12_A0101_SEQ_1426
Figure 12_A0101_SEQ_1427
Figure 12_A0101_SEQ_1428
Figure 12_A0101_SEQ_1429
Figure 12_A0101_SEQ_1430
Figure 12_A0101_SEQ_1431
Figure 12_A0101_SEQ_1432
Figure 12_A0101_SEQ_1433
Figure 12_A0101_SEQ_1434
Figure 12_A0101_SEQ_1435
Figure 12_A0101_SEQ_1436
Figure 12_A0101_SEQ_1437
Figure 12_A0101_SEQ_1438
Figure 12_A0101_SEQ_1439
Figure 12_A0101_SEQ_1440
Figure 12_A0101_SEQ_1441
Figure 12_A0101_SEQ_1442
Figure 12_A0101_SEQ_1443
Figure 12_A0101_SEQ_1444
Figure 12_A0101_SEQ_1445
Figure 12_A0101_SEQ_1446
Figure 12_A0101_SEQ_1447
Figure 12_A0101_SEQ_1448
Figure 12_A0101_SEQ_1449
Figure 12_A0101_SEQ_1450
Figure 12_A0101_SEQ_1451
Figure 12_A0101_SEQ_1452
Figure 12_A0101_SEQ_1453
Figure 12_A0101_SEQ_1454
Figure 12_A0101_SEQ_1455
Figure 12_A0101_SEQ_1456
Figure 12_A0101_SEQ_1457
Figure 12_A0101_SEQ_1458
Figure 12_A0101_SEQ_1459
Figure 12_A0101_SEQ_1460
Figure 12_A0101_SEQ_1461
Figure 12_A0101_SEQ_1462
Figure 12_A0101_SEQ_1463
Figure 12_A0101_SEQ_1464
Figure 12_A0101_SEQ_1465
Figure 12_A0101_SEQ_1466
Figure 12_A0101_SEQ_1467
Figure 12_A0101_SEQ_1468
Figure 12_A0101_SEQ_1469
Figure 12_A0101_SEQ_1470
Figure 12_A0101_SEQ_1471
Figure 12_A0101_SEQ_1472
Figure 12_A0101_SEQ_1473
Figure 12_A0101_SEQ_1474
Figure 12_A0101_SEQ_1475
Figure 12_A0101_SEQ_1476
Figure 12_A0101_SEQ_1477
Figure 12_A0101_SEQ_1478
Figure 12_A0101_SEQ_1479
Figure 12_A0101_SEQ_1480
Figure 12_A0101_SEQ_1481
Figure 12_A0101_SEQ_1482
Figure 12_A0101_SEQ_1483
Figure 12_A0101_SEQ_1484
Figure 12_A0101_SEQ_1485
Figure 12_A0101_SEQ_1486
Figure 12_A0101_SEQ_1487
Figure 12_A0101_SEQ_1488
Figure 12_A0101_SEQ_1489
Figure 12_A0101_SEQ_1490
Figure 12_A0101_SEQ_1491
Figure 12_A0101_SEQ_1492
Figure 12_A0101_SEQ_1493
Figure 12_A0101_SEQ_1494
Figure 12_A0101_SEQ_1495
Figure 12_A0101_SEQ_1496
Figure 12_A0101_SEQ_1497
Figure 12_A0101_SEQ_1498
Figure 12_A0101_SEQ_1499
Figure 12_A0101_SEQ_1500
Figure 12_A0101_SEQ_1501
Figure 12_A0101_SEQ_1502
Figure 12_A0101_SEQ_1503
Figure 12_A0101_SEQ_1504
Figure 12_A0101_SEQ_1505
Figure 12_A0101_SEQ_1506
Figure 12_A0101_SEQ_1507
Figure 12_A0101_SEQ_1508
Figure 12_A0101_SEQ_1509
Figure 12_A0101_SEQ_1510
Figure 12_A0101_SEQ_1511
Figure 12_A0101_SEQ_1512
Figure 12_A0101_SEQ_1513
Figure 12_A0101_SEQ_1514
Figure 12_A0101_SEQ_1515
Figure 12_A0101_SEQ_1516
Figure 12_A0101_SEQ_1517
Figure 12_A0101_SEQ_1518
Figure 12_A0101_SEQ_1519
Figure 12_A0101_SEQ_1520
Figure 12_A0101_SEQ_1521
Figure 12_A0101_SEQ_1522
Figure 12_A0101_SEQ_1523
Figure 12_A0101_SEQ_1524
Figure 12_A0101_SEQ_1525
Figure 12_A0101_SEQ_1526
Figure 12_A0101_SEQ_1527
Figure 12_A0101_SEQ_1528
Figure 12_A0101_SEQ_1529
Figure 12_A0101_SEQ_1530
Figure 12_A0101_SEQ_1531
Figure 12_A0101_SEQ_1532
Figure 12_A0101_SEQ_1533
Figure 12_A0101_SEQ_1534
Figure 12_A0101_SEQ_1535
Figure 12_A0101_SEQ_1536
Figure 12_A0101_SEQ_1537
Figure 12_A0101_SEQ_1538
Figure 12_A0101_SEQ_1539
Figure 12_A0101_SEQ_1540
Figure 12_A0101_SEQ_1541
Figure 12_A0101_SEQ_1542
Figure 12_A0101_SEQ_1543
Figure 12_A0101_SEQ_1544
Figure 12_A0101_SEQ_1545
Figure 12_A0101_SEQ_1546
Figure 12_A0101_SEQ_1547
Figure 12_A0101_SEQ_1548
Figure 12_A0101_SEQ_1549
Figure 12_A0101_SEQ_1550
Figure 12_A0101_SEQ_1551
Figure 12_A0101_SEQ_1552
Figure 12_A0101_SEQ_1553
Figure 12_A0101_SEQ_1554
Figure 12_A0101_SEQ_1555
Figure 12_A0101_SEQ_1556
Figure 12_A0101_SEQ_1557
Figure 12_A0101_SEQ_1558
Figure 12_A0101_SEQ_1559
Figure 12_A0101_SEQ_1560
Figure 12_A0101_SEQ_1561
Figure 12_A0101_SEQ_1562
Figure 12_A0101_SEQ_1563
Figure 12_A0101_SEQ_1564
Figure 12_A0101_SEQ_1565
Figure 12_A0101_SEQ_1566
Figure 12_A0101_SEQ_1567
Figure 12_A0101_SEQ_1568
Figure 12_A0101_SEQ_1569
Figure 12_A0101_SEQ_1570
Figure 12_A0101_SEQ_1571
Figure 12_A0101_SEQ_1572
Figure 12_A0101_SEQ_1573
Figure 12_A0101_SEQ_1574
Figure 12_A0101_SEQ_1575
Figure 12_A0101_SEQ_1576
Figure 12_A0101_SEQ_1577
Figure 12_A0101_SEQ_1578
Figure 12_A0101_SEQ_1579
Figure 12_A0101_SEQ_1580
Figure 12_A0101_SEQ_1581
Figure 12_A0101_SEQ_1582
Figure 12_A0101_SEQ_1583
Figure 12_A0101_SEQ_1584
Figure 12_A0101_SEQ_1585
Figure 12_A0101_SEQ_1586
Figure 12_A0101_SEQ_1587
Figure 12_A0101_SEQ_1588
Figure 12_A0101_SEQ_1589
Figure 12_A0101_SEQ_1590
Figure 12_A0101_SEQ_1591
Figure 12_A0101_SEQ_1592
Figure 12_A0101_SEQ_1593
Figure 12_A0101_SEQ_1594
Figure 12_A0101_SEQ_1595
Figure 12_A0101_SEQ_1596
Figure 12_A0101_SEQ_1597
Figure 12_A0101_SEQ_1598
Figure 12_A0101_SEQ_1599
Figure 12_A0101_SEQ_1600
Figure 12_A0101_SEQ_1601
Figure 12_A0101_SEQ_1602
Figure 12_A0101_SEQ_1603
Figure 12_A0101_SEQ_1604
Figure 12_A0101_SEQ_1605
Figure 12_A0101_SEQ_1606
Figure 12_A0101_SEQ_1607
Figure 12_A0101_SEQ_1608
Figure 12_A0101_SEQ_1609
Figure 12_A0101_SEQ_1610
Figure 12_A0101_SEQ_1611
Figure 12_A0101_SEQ_1612
Figure 12_A0101_SEQ_1613
Figure 12_A0101_SEQ_1614
Figure 12_A0101_SEQ_1615
Figure 12_A0101_SEQ_1616
Figure 12_A0101_SEQ_1617
Figure 12_A0101_SEQ_1618
Figure 12_A0101_SEQ_1619
Figure 12_A0101_SEQ_1620
Figure 12_A0101_SEQ_1621
Figure 12_A0101_SEQ_1622
Figure 12_A0101_SEQ_1623
Figure 12_A0101_SEQ_1624
Figure 12_A0101_SEQ_1625
Figure 12_A0101_SEQ_1626
Figure 12_A0101_SEQ_1627
Figure 12_A0101_SEQ_1628
Figure 12_A0101_SEQ_1629
Figure 12_A0101_SEQ_1630
Figure 12_A0101_SEQ_1631
Figure 12_A0101_SEQ_1632
Figure 12_A0101_SEQ_1633
Figure 12_A0101_SEQ_1634
Figure 12_A0101_SEQ_1635
Figure 12_A0101_SEQ_1636
Figure 12_A0101_SEQ_1637
Figure 12_A0101_SEQ_1638
Figure 12_A0101_SEQ_1639
Figure 12_A0101_SEQ_1640
Figure 12_A0101_SEQ_1641
Figure 12_A0101_SEQ_1642
Figure 12_A0101_SEQ_1643
Figure 12_A0101_SEQ_1644
Figure 12_A0101_SEQ_1645
Figure 12_A0101_SEQ_1646
Figure 12_A0101_SEQ_1647
Figure 12_A0101_SEQ_1648
Figure 12_A0101_SEQ_1649
Figure 12_A0101_SEQ_1650
Figure 12_A0101_SEQ_1651
Figure 12_A0101_SEQ_1652
Figure 12_A0101_SEQ_1653
Figure 12_A0101_SEQ_1654
Figure 12_A0101_SEQ_1655
Figure 12_A0101_SEQ_1656
Figure 12_A0101_SEQ_1657
Figure 12_A0101_SEQ_1658
Figure 12_A0101_SEQ_1659
Figure 12_A0101_SEQ_1660
Figure 12_A0101_SEQ_1661
Figure 12_A0101_SEQ_1662
Figure 12_A0101_SEQ_1663
Figure 12_A0101_SEQ_1664
Figure 12_A0101_SEQ_1665
Figure 12_A0101_SEQ_1666
Figure 12_A0101_SEQ_1667
Figure 12_A0101_SEQ_1668
Figure 12_A0101_SEQ_1669
Figure 12_A0101_SEQ_1670
Figure 12_A0101_SEQ_1671
Figure 12_A0101_SEQ_1672
Figure 12_A0101_SEQ_1673
Figure 12_A0101_SEQ_1674
Figure 12_A0101_SEQ_1675
Figure 12_A0101_SEQ_1676
Figure 12_A0101_SEQ_1677
Figure 12_A0101_SEQ_1678
Figure 12_A0101_SEQ_1679
Figure 12_A0101_SEQ_1680
Figure 12_A0101_SEQ_1681
Figure 12_A0101_SEQ_1682
Figure 12_A0101_SEQ_1683
Figure 12_A0101_SEQ_1684
Figure 12_A0101_SEQ_1685
Figure 12_A0101_SEQ_1686
Figure 12_A0101_SEQ_1687
Figure 12_A0101_SEQ_1688
Figure 12_A0101_SEQ_1689
Figure 12_A0101_SEQ_1690
Figure 12_A0101_SEQ_1691
Figure 12_A0101_SEQ_1692
Figure 12_A0101_SEQ_1693
Figure 12_A0101_SEQ_1694
Figure 12_A0101_SEQ_1695
Figure 12_A0101_SEQ_1696
Figure 12_A0101_SEQ_1697
Figure 12_A0101_SEQ_1698
Figure 12_A0101_SEQ_1699
Figure 12_A0101_SEQ_1700
Figure 12_A0101_SEQ_1701
Figure 12_A0101_SEQ_1702
Figure 12_A0101_SEQ_1703
Figure 12_A0101_SEQ_1704
Figure 12_A0101_SEQ_1705
Figure 12_A0101_SEQ_1706
Figure 12_A0101_SEQ_1707
Figure 12_A0101_SEQ_1708
Figure 12_A0101_SEQ_1709
Figure 12_A0101_SEQ_1710
Figure 12_A0101_SEQ_1711
Figure 12_A0101_SEQ_1712
Figure 12_A0101_SEQ_1713
Figure 12_A0101_SEQ_1714
Figure 12_A0101_SEQ_1715
Figure 12_A0101_SEQ_1716
Figure 12_A0101_SEQ_1717
Figure 12_A0101_SEQ_1718
Figure 12_A0101_SEQ_1719
Figure 12_A0101_SEQ_1720
Figure 12_A0101_SEQ_1721
Figure 12_A0101_SEQ_1722
Figure 12_A0101_SEQ_1723
Figure 12_A0101_SEQ_1724
Figure 12_A0101_SEQ_1725
Figure 12_A0101_SEQ_1726
Figure 12_A0101_SEQ_1727
Figure 12_A0101_SEQ_1728
Figure 12_A0101_SEQ_1729
Figure 12_A0101_SEQ_1730
Figure 12_A0101_SEQ_1731
Figure 12_A0101_SEQ_1732
Figure 12_A0101_SEQ_1733
Figure 12_A0101_SEQ_1734
Figure 12_A0101_SEQ_1735
Figure 12_A0101_SEQ_1736
Figure 12_A0101_SEQ_1737
Figure 12_A0101_SEQ_1738
Figure 12_A0101_SEQ_1739
Figure 12_A0101_SEQ_1740
Figure 12_A0101_SEQ_1741
Figure 12_A0101_SEQ_1742
Figure 12_A0101_SEQ_1743
Figure 12_A0101_SEQ_1744
Figure 12_A0101_SEQ_1745
Figure 12_A0101_SEQ_1746
Figure 12_A0101_SEQ_1747
Figure 12_A0101_SEQ_1748
Figure 12_A0101_SEQ_1749
Figure 12_A0101_SEQ_1750
Figure 12_A0101_SEQ_1751
Figure 12_A0101_SEQ_1752
Figure 12_A0101_SEQ_1753
Figure 12_A0101_SEQ_1754
Figure 12_A0101_SEQ_1755
Figure 12_A0101_SEQ_1756
Figure 12_A0101_SEQ_1757
Figure 12_A0101_SEQ_1758
Figure 12_A0101_SEQ_1759
Figure 12_A0101_SEQ_1760
Figure 12_A0101_SEQ_1761
Figure 12_A0101_SEQ_1762
Figure 12_A0101_SEQ_1763
Figure 12_A0101_SEQ_1764
Figure 12_A0101_SEQ_1765
Figure 12_A0101_SEQ_1766
Figure 12_A0101_SEQ_1767
Figure 12_A0101_SEQ_1768
Figure 12_A0101_SEQ_1769
Figure 12_A0101_SEQ_1770
Figure 12_A0101_SEQ_1771
Figure 12_A0101_SEQ_1772
Figure 12_A0101_SEQ_1773
Figure 12_A0101_SEQ_1774
Figure 12_A0101_SEQ_1775
Figure 12_A0101_SEQ_1776
Figure 12_A0101_SEQ_1777
Figure 12_A0101_SEQ_1778
Figure 12_A0101_SEQ_1779
Figure 12_A0101_SEQ_1780
Figure 12_A0101_SEQ_1781
Figure 12_A0101_SEQ_1782
Figure 12_A0101_SEQ_1783
Figure 12_A0101_SEQ_1784
Figure 12_A0101_SEQ_1785
Figure 12_A0101_SEQ_1786
Figure 12_A0101_SEQ_1787
Figure 12_A0101_SEQ_1788
Figure 12_A0101_SEQ_1789
Figure 12_A0101_SEQ_1790
Figure 12_A0101_SEQ_1791
Figure 12_A0101_SEQ_1792
Figure 12_A0101_SEQ_1793
Figure 12_A0101_SEQ_1794
Figure 12_A0101_SEQ_1795
Figure 12_A0101_SEQ_1796
Figure 12_A0101_SEQ_1797
Figure 12_A0101_SEQ_1798
Figure 12_A0101_SEQ_1799
Figure 12_A0101_SEQ_1800
Figure 12_A0101_SEQ_1801
Figure 12_A0101_SEQ_1802
Figure 12_A0101_SEQ_1803
Figure 12_A0101_SEQ_1804
Figure 12_A0101_SEQ_1805
Figure 12_A0101_SEQ_1806
Figure 12_A0101_SEQ_1807
Figure 12_A0101_SEQ_1808
Figure 12_A0101_SEQ_1809
Figure 12_A0101_SEQ_1810
Figure 12_A0101_SEQ_1811
Figure 12_A0101_SEQ_1812
Figure 12_A0101_SEQ_1813
Figure 12_A0101_SEQ_1814
Figure 12_A0101_SEQ_1815
Figure 12_A0101_SEQ_1816
Figure 12_A0101_SEQ_1817
Figure 12_A0101_SEQ_1818
Figure 12_A0101_SEQ_1819
Figure 12_A0101_SEQ_1820
Figure 12_A0101_SEQ_1821
Figure 12_A0101_SEQ_1822
Figure 12_A0101_SEQ_1823
Figure 12_A0101_SEQ_1824
Figure 12_A0101_SEQ_1825
Figure 12_A0101_SEQ_1826
Figure 12_A0101_SEQ_1827
Figure 12_A0101_SEQ_1828
Figure 12_A0101_SEQ_1829
Figure 12_A0101_SEQ_1830
Figure 12_A0101_SEQ_1831
Figure 12_A0101_SEQ_1832
Figure 12_A0101_SEQ_1833
Figure 12_A0101_SEQ_1834
Figure 12_A0101_SEQ_1835
Figure 12_A0101_SEQ_1836
Figure 12_A0101_SEQ_1837
Figure 12_A0101_SEQ_1838
Figure 12_A0101_SEQ_1839
Figure 12_A0101_SEQ_1840
Figure 12_A0101_SEQ_1841
Figure 12_A0101_SEQ_1842
Figure 12_A0101_SEQ_1843
Figure 12_A0101_SEQ_1844
Figure 12_A0101_SEQ_1845
Figure 12_A0101_SEQ_1846
Figure 12_A0101_SEQ_1847
Figure 12_A0101_SEQ_1848
Figure 12_A0101_SEQ_1849
Figure 12_A0101_SEQ_1850
Figure 12_A0101_SEQ_1851
Figure 12_A0101_SEQ_1852
Figure 12_A0101_SEQ_1853
Figure 12_A0101_SEQ_1854
Figure 12_A0101_SEQ_1855
Figure 12_A0101_SEQ_1856
Figure 12_A0101_SEQ_1857
Figure 12_A0101_SEQ_1858
Figure 12_A0101_SEQ_1859
Figure 12_A0101_SEQ_1860
Figure 12_A0101_SEQ_1861
Figure 12_A0101_SEQ_1862
Figure 12_A0101_SEQ_1863
Figure 12_A0101_SEQ_1864
Figure 12_A0101_SEQ_1865
Figure 12_A0101_SEQ_1866
Figure 12_A0101_SEQ_1867
Figure 12_A0101_SEQ_1868
Figure 12_A0101_SEQ_1869
Figure 12_A0101_SEQ_1870
Figure 12_A0101_SEQ_1871
Figure 12_A0101_SEQ_1872
Figure 12_A0101_SEQ_1873
Figure 12_A0101_SEQ_1874
Figure 12_A0101_SEQ_1875
Figure 12_A0101_SEQ_1876
Figure 12_A0101_SEQ_1877
Figure 12_A0101_SEQ_1878
Figure 12_A0101_SEQ_1879
Figure 12_A0101_SEQ_1880
Figure 12_A0101_SEQ_1881
Figure 12_A0101_SEQ_1882
Figure 12_A0101_SEQ_1883
Figure 12_A0101_SEQ_1884
Figure 12_A0101_SEQ_1885
Figure 12_A0101_SEQ_1886
Figure 12_A0101_SEQ_1887
Figure 12_A0101_SEQ_1888
Figure 12_A0101_SEQ_1889
Figure 12_A0101_SEQ_1890
Figure 12_A0101_SEQ_1891
Figure 12_A0101_SEQ_1892
Figure 12_A0101_SEQ_1893
Figure 12_A0101_SEQ_1894
Figure 12_A0101_SEQ_1895
Figure 12_A0101_SEQ_1896
Figure 12_A0101_SEQ_1897
Figure 12_A0101_SEQ_1898
Figure 12_A0101_SEQ_1899
Figure 12_A0101_SEQ_1900
Figure 12_A0101_SEQ_1901
Figure 12_A0101_SEQ_1902
Figure 12_A0101_SEQ_1903
Figure 12_A0101_SEQ_1904
Figure 12_A0101_SEQ_1905
Figure 12_A0101_SEQ_1906
Figure 12_A0101_SEQ_1907
Figure 12_A0101_SEQ_1908
Figure 12_A0101_SEQ_1909
Figure 12_A0101_SEQ_1910
Figure 12_A0101_SEQ_1911
Figure 12_A0101_SEQ_1912
Figure 12_A0101_SEQ_1913
Figure 12_A0101_SEQ_1914
Figure 12_A0101_SEQ_1915
Figure 12_A0101_SEQ_1916
Figure 12_A0101_SEQ_1917
Figure 12_A0101_SEQ_1918
Figure 12_A0101_SEQ_1919
Figure 12_A0101_SEQ_1920
Figure 12_A0101_SEQ_1921
Figure 12_A0101_SEQ_1922
Figure 12_A0101_SEQ_1923
Figure 12_A0101_SEQ_1924
Figure 12_A0101_SEQ_1925
Figure 12_A0101_SEQ_1926
Figure 12_A0101_SEQ_1927
Figure 12_A0101_SEQ_1928
Figure 12_A0101_SEQ_1929
Figure 12_A0101_SEQ_1930
Figure 12_A0101_SEQ_1931
Figure 12_A0101_SEQ_1932
Figure 12_A0101_SEQ_1933
Figure 12_A0101_SEQ_1934
Figure 12_A0101_SEQ_1935
Figure 12_A0101_SEQ_1936
Figure 12_A0101_SEQ_1937
Figure 12_A0101_SEQ_1938
Figure 12_A0101_SEQ_1939
Figure 12_A0101_SEQ_1940
Figure 12_A0101_SEQ_1941
Figure 12_A0101_SEQ_1942
Figure 12_A0101_SEQ_1943
Figure 12_A0101_SEQ_1944
Figure 12_A0101_SEQ_1945
Figure 12_A0101_SEQ_1946
Figure 12_A0101_SEQ_1947
Figure 12_A0101_SEQ_1948
Figure 12_A0101_SEQ_1949
Figure 12_A0101_SEQ_1950
Figure 12_A0101_SEQ_1951
Figure 12_A0101_SEQ_1952
Figure 12_A0101_SEQ_1953
Figure 12_A0101_SEQ_1954
Figure 12_A0101_SEQ_1955
Figure 12_A0101_SEQ_1956
Figure 12_A0101_SEQ_1957
Figure 12_A0101_SEQ_1958
Figure 12_A0101_SEQ_1959
Figure 12_A0101_SEQ_1960
Figure 12_A0101_SEQ_1961
Figure 12_A0101_SEQ_1962
Figure 12_A0101_SEQ_1963
Figure 12_A0101_SEQ_1964
Figure 12_A0101_SEQ_1965
Figure 12_A0101_SEQ_1966
Figure 12_A0101_SEQ_1967
Figure 12_A0101_SEQ_1968
Figure 12_A0101_SEQ_1969
Figure 12_A0101_SEQ_1970
Figure 12_A0101_SEQ_1971
Figure 12_A0101_SEQ_1972
Figure 12_A0101_SEQ_1973
Figure 12_A0101_SEQ_1974
Figure 12_A0101_SEQ_1975
Figure 12_A0101_SEQ_1976
Figure 12_A0101_SEQ_1977
Figure 12_A0101_SEQ_1978
Figure 12_A0101_SEQ_1979
Figure 12_A0101_SEQ_1980
Figure 12_A0101_SEQ_1981
Figure 12_A0101_SEQ_1982
Figure 12_A0101_SEQ_1983
Figure 12_A0101_SEQ_1984
Figure 12_A0101_SEQ_1985
Figure 12_A0101_SEQ_1986
Figure 12_A0101_SEQ_1987
Figure 12_A0101_SEQ_1988
Figure 12_A0101_SEQ_1989
Figure 12_A0101_SEQ_1990
Figure 12_A0101_SEQ_1991
Figure 12_A0101_SEQ_1992
Figure 12_A0101_SEQ_1993
Figure 12_A0101_SEQ_1994
Figure 12_A0101_SEQ_1995
Figure 12_A0101_SEQ_1996
Figure 12_A0101_SEQ_1997
Figure 12_A0101_SEQ_1998
Figure 12_A0101_SEQ_1999
Figure 12_A0101_SEQ_2000
Figure 12_A0101_SEQ_2001
Figure 12_A0101_SEQ_2002
Figure 12_A0101_SEQ_2003
Figure 12_A0101_SEQ_2004
Figure 12_A0101_SEQ_2005
Figure 12_A0101_SEQ_2006
Figure 12_A0101_SEQ_2007
Figure 12_A0101_SEQ_2008
Figure 12_A0101_SEQ_2009
Figure 12_A0101_SEQ_2010
Figure 12_A0101_SEQ_2011
Figure 12_A0101_SEQ_2012
Figure 12_A0101_SEQ_2013
Figure 12_A0101_SEQ_2014
Figure 12_A0101_SEQ_2015
Figure 12_A0101_SEQ_2016
Figure 12_A0101_SEQ_2017
Figure 12_A0101_SEQ_2018
Figure 12_A0101_SEQ_2019
Figure 12_A0101_SEQ_2020
Figure 12_A0101_SEQ_2021
Figure 12_A0101_SEQ_2022
Figure 12_A0101_SEQ_2023
Figure 12_A0101_SEQ_2024
Figure 12_A0101_SEQ_2025
Figure 12_A0101_SEQ_2026
Figure 12_A0101_SEQ_2027
Figure 12_A0101_SEQ_2028
Figure 12_A0101_SEQ_2029
Figure 12_A0101_SEQ_2030
Figure 12_A0101_SEQ_2031
Figure 12_A0101_SEQ_2032
Figure 12_A0101_SEQ_2033
Figure 12_A0101_SEQ_2034
Figure 12_A0101_SEQ_2035
Figure 12_A0101_SEQ_2036
Figure 12_A0101_SEQ_2037
Figure 12_A0101_SEQ_2038
Figure 12_A0101_SEQ_2039
Figure 12_A0101_SEQ_2040
Figure 12_A0101_SEQ_2041
Figure 12_A0101_SEQ_2042
Figure 12_A0101_SEQ_2043
Figure 12_A0101_SEQ_2044
Figure 12_A0101_SEQ_2045
Figure 12_A0101_SEQ_2046
Figure 12_A0101_SEQ_2047
Figure 12_A0101_SEQ_2048
Figure 12_A0101_SEQ_2049
Figure 12_A0101_SEQ_2050
Figure 12_A0101_SEQ_2051
Figure 12_A0101_SEQ_2052
Figure 12_A0101_SEQ_2053
Figure 12_A0101_SEQ_2054
Figure 12_A0101_SEQ_2055
Figure 12_A0101_SEQ_2056
Figure 12_A0101_SEQ_2057
Figure 12_A0101_SEQ_2058
Figure 12_A0101_SEQ_2059
Figure 12_A0101_SEQ_2060
Figure 12_A0101_SEQ_2061
Figure 12_A0101_SEQ_2062
Figure 12_A0101_SEQ_2063
Figure 12_A0101_SEQ_2064
Figure 12_A0101_SEQ_2065
Figure 12_A0101_SEQ_2066
Figure 12_A0101_SEQ_2067
Figure 12_A0101_SEQ_2068
Figure 12_A0101_SEQ_2069
Figure 12_A0101_SEQ_2070
Figure 12_A0101_SEQ_2071
Figure 12_A0101_SEQ_2072
Figure 12_A0101_SEQ_2073
Figure 12_A0101_SEQ_2074
Figure 12_A0101_SEQ_2075
Figure 12_A0101_SEQ_2076
Figure 12_A0101_SEQ_2077
Figure 12_A0101_SEQ_2078
Figure 12_A0101_SEQ_2079
Figure 12_A0101_SEQ_2080
Figure 12_A0101_SEQ_2081
Figure 12_A0101_SEQ_2082
Figure 12_A0101_SEQ_2083
Figure 12_A0101_SEQ_2084
Figure 12_A0101_SEQ_2085
Figure 12_A0101_SEQ_2086
Figure 12_A0101_SEQ_2087
Figure 12_A0101_SEQ_2088
Figure 12_A0101_SEQ_2089
Figure 12_A0101_SEQ_2090
Figure 12_A0101_SEQ_2091
Figure 12_A0101_SEQ_2092
Figure 12_A0101_SEQ_2093
Figure 12_A0101_SEQ_2094
Figure 12_A0101_SEQ_2095
Figure 12_A0101_SEQ_2096
Figure 12_A0101_SEQ_2097
Figure 12_A0101_SEQ_2098
Figure 12_A0101_SEQ_2099
Figure 12_A0101_SEQ_2100
Figure 12_A0101_SEQ_2101
Figure 12_A0101_SEQ_2102
Figure 12_A0101_SEQ_2103
Figure 12_A0101_SEQ_2104
Figure 12_A0101_SEQ_2105
Figure 12_A0101_SEQ_2106
Figure 12_A0101_SEQ_2107
Figure 12_A0101_SEQ_2108
Figure 12_A0101_SEQ_2109
Figure 12_A0101_SEQ_2110
Figure 12_A0101_SEQ_2111
Figure 12_A0101_SEQ_2112
Figure 12_A0101_SEQ_2113
Figure 12_A0101_SEQ_2114
Figure 12_A0101_SEQ_2115
Figure 12_A0101_SEQ_2116
Figure 12_A0101_SEQ_2117
Figure 12_A0101_SEQ_2118
Figure 12_A0101_SEQ_2119
Figure 12_A0101_SEQ_2120
Figure 12_A0101_SEQ_2121
Figure 12_A0101_SEQ_2122
Figure 12_A0101_SEQ_2123
Figure 12_A0101_SEQ_2124
Figure 12_A0101_SEQ_2125
Figure 12_A0101_SEQ_2126
Figure 12_A0101_SEQ_2127
Figure 12_A0101_SEQ_2128
Figure 12_A0101_SEQ_2129
Figure 12_A0101_SEQ_2130
Figure 12_A0101_SEQ_2131
Figure 12_A0101_SEQ_2132
Figure 12_A0101_SEQ_2133
Figure 12_A0101_SEQ_2134
Figure 12_A0101_SEQ_2135
Figure 12_A0101_SEQ_2136
Figure 12_A0101_SEQ_2137
Figure 12_A0101_SEQ_2138
Figure 12_A0101_SEQ_2139
Figure 12_A0101_SEQ_2140
Figure 12_A0101_SEQ_2141
Figure 12_A0101_SEQ_2142
Figure 12_A0101_SEQ_2143
Figure 12_A0101_SEQ_2144
Figure 12_A0101_SEQ_2145
Figure 12_A0101_SEQ_2146
Figure 12_A0101_SEQ_2147
Figure 12_A0101_SEQ_2148
Figure 12_A0101_SEQ_2149
Figure 12_A0101_SEQ_2150
Figure 12_A0101_SEQ_2151
Figure 12_A0101_SEQ_2152
Figure 12_A0101_SEQ_2153
Figure 12_A0101_SEQ_2154
Figure 12_A0101_SEQ_2155
Figure 12_A0101_SEQ_2156
Figure 12_A0101_SEQ_2157
Figure 12_A0101_SEQ_2158
Figure 12_A0101_SEQ_2159
Figure 12_A0101_SEQ_2160
Figure 12_A0101_SEQ_2161
Figure 12_A0101_SEQ_2162
Figure 12_A0101_SEQ_2163
Figure 12_A0101_SEQ_2164
Figure 12_A0101_SEQ_2165
Figure 12_A0101_SEQ_2166
Figure 12_A0101_SEQ_2167
Figure 12_A0101_SEQ_2168
Figure 12_A0101_SEQ_2169
Figure 12_A0101_SEQ_2170
Figure 12_A0101_SEQ_2171
Figure 12_A0101_SEQ_2172
Figure 12_A0101_SEQ_2173
Figure 12_A0101_SEQ_2174
Figure 12_A0101_SEQ_2175
Figure 12_A0101_SEQ_2176
Figure 12_A0101_SEQ_2177
Figure 12_A0101_SEQ_2178
Figure 12_A0101_SEQ_2179
Figure 12_A0101_SEQ_2180
Figure 12_A0101_SEQ_2181
Figure 12_A0101_SEQ_2182
Figure 12_A0101_SEQ_2183
Figure 12_A0101_SEQ_2184
Figure 12_A0101_SEQ_2185
Figure 12_A0101_SEQ_2186
Figure 12_A0101_SEQ_2187
Figure 12_A0101_SEQ_2188
Figure 12_A0101_SEQ_2189
Figure 12_A0101_SEQ_2190
Figure 12_A0101_SEQ_2191
Figure 12_A0101_SEQ_2192
Figure 12_A0101_SEQ_2193
Figure 12_A0101_SEQ_2194
Figure 12_A0101_SEQ_2195
Figure 12_A0101_SEQ_2196
Figure 12_A0101_SEQ_2197
Figure 12_A0101_SEQ_2198
Figure 12_A0101_SEQ_2199
Figure 12_A0101_SEQ_2200
Figure 12_A0101_SEQ_2201
Figure 12_A0101_SEQ_2202
Figure 12_A0101_SEQ_2203
Figure 12_A0101_SEQ_2204
Figure 12_A0101_SEQ_2205
Figure 12_A0101_SEQ_2206
Figure 12_A0101_SEQ_2207
Figure 12_A0101_SEQ_2208
Figure 12_A0101_SEQ_2209
Figure 12_A0101_SEQ_2210
Figure 12_A0101_SEQ_2211
Figure 12_A0101_SEQ_2212
Figure 12_A0101_SEQ_2213
Figure 12_A0101_SEQ_2214
Figure 12_A0101_SEQ_2215
Figure 12_A0101_SEQ_2216
Figure 12_A0101_SEQ_2217
Figure 12_A0101_SEQ_2218
Figure 12_A0101_SEQ_2219
Figure 12_A0101_SEQ_2220
Figure 12_A0101_SEQ_2221
Figure 12_A0101_SEQ_2222
Figure 12_A0101_SEQ_2223
Figure 12_A0101_SEQ_2224
Figure 12_A0101_SEQ_2225
Figure 12_A0101_SEQ_2226
Figure 12_A0101_SEQ_2227
Figure 12_A0101_SEQ_2228
Figure 12_A0101_SEQ_2229
Figure 12_A0101_SEQ_2230
Figure 12_A0101_SEQ_2231
Figure 12_A0101_SEQ_2232
Figure 12_A0101_SEQ_2233
Figure 12_A0101_SEQ_2234
Figure 12_A0101_SEQ_2235
Figure 12_A0101_SEQ_2236
Figure 12_A0101_SEQ_2237
Figure 12_A0101_SEQ_2238
Figure 12_A0101_SEQ_2239
Figure 12_A0101_SEQ_2240
Figure 12_A0101_SEQ_2241
Figure 12_A0101_SEQ_2242
Figure 12_A0101_SEQ_2243
Figure 12_A0101_SEQ_2244
Figure 12_A0101_SEQ_2245
Figure 12_A0101_SEQ_2246
Figure 12_A0101_SEQ_2247
Figure 12_A0101_SEQ_2248
Figure 12_A0101_SEQ_2249
Figure 12_A0101_SEQ_2250
Figure 12_A0101_SEQ_2251
Figure 12_A0101_SEQ_2252
Figure 12_A0101_SEQ_2253
Figure 12_A0101_SEQ_2254
Figure 12_A0101_SEQ_2255
Figure 12_A0101_SEQ_2256
Figure 12_A0101_SEQ_2257
Figure 12_A0101_SEQ_2258
Figure 12_A0101_SEQ_2259
Figure 12_A0101_SEQ_2260
Figure 12_A0101_SEQ_2261
Figure 12_A0101_SEQ_2262
Figure 12_A0101_SEQ_2263
Figure 12_A0101_SEQ_2264
Figure 12_A0101_SEQ_2265
Figure 12_A0101_SEQ_2266
Figure 12_A0101_SEQ_2267
Figure 12_A0101_SEQ_2268
Figure 12_A0101_SEQ_2269
Figure 12_A0101_SEQ_2270
Figure 12_A0101_SEQ_2271
Figure 12_A0101_SEQ_2272
Figure 12_A0101_SEQ_2273
Figure 12_A0101_SEQ_2274
Figure 12_A0101_SEQ_2275
Figure 12_A0101_SEQ_2276
Figure 12_A0101_SEQ_2277
Figure 12_A0101_SEQ_2278
Figure 12_A0101_SEQ_2279
Figure 12_A0101_SEQ_2280
Figure 12_A0101_SEQ_2281
Figure 12_A0101_SEQ_2282
Figure 12_A0101_SEQ_2283
Figure 12_A0101_SEQ_2284
Figure 12_A0101_SEQ_2285
Figure 12_A0101_SEQ_2286
Figure 12_A0101_SEQ_2287
Figure 12_A0101_SEQ_2288
Figure 12_A0101_SEQ_2289
Figure 12_A0101_SEQ_2290
Figure 12_A0101_SEQ_2291
Figure 12_A0101_SEQ_2292
Figure 12_A0101_SEQ_2293
Figure 12_A0101_SEQ_2294
Figure 12_A0101_SEQ_2295
Figure 12_A0101_SEQ_2296
Figure 12_A0101_SEQ_2297
Figure 12_A0101_SEQ_2298
Figure 12_A0101_SEQ_2299
Figure 12_A0101_SEQ_2300
Figure 12_A0101_SEQ_2301
Figure 12_A0101_SEQ_2302
Figure 12_A0101_SEQ_2303
Figure 12_A0101_SEQ_2304
Figure 12_A0101_SEQ_2305
Figure 12_A0101_SEQ_2306
Figure 12_A0101_SEQ_2307
Figure 12_A0101_SEQ_2308
Figure 12_A0101_SEQ_2309
Figure 12_A0101_SEQ_2310
Figure 12_A0101_SEQ_2311
Figure 12_A0101_SEQ_2312
Figure 12_A0101_SEQ_2313
Figure 12_A0101_SEQ_2314
Figure 12_A0101_SEQ_2315
Figure 12_A0101_SEQ_2316
Figure 12_A0101_SEQ_2317
Figure 12_A0101_SEQ_2318
Figure 12_A0101_SEQ_2319
Figure 12_A0101_SEQ_2320
Figure 12_A0101_SEQ_2321
Figure 12_A0101_SEQ_2322
Figure 12_A0101_SEQ_2323
Figure 12_A0101_SEQ_2324
Figure 12_A0101_SEQ_2325
Figure 12_A0101_SEQ_2326
Figure 12_A0101_SEQ_2327
Figure 12_A0101_SEQ_2328
Figure 12_A0101_SEQ_2329
Figure 12_A0101_SEQ_2330
Figure 12_A0101_SEQ_2331
Figure 12_A0101_SEQ_2332
Figure 12_A0101_SEQ_2333
Figure 12_A0101_SEQ_2334
Figure 12_A0101_SEQ_2335
Figure 12_A0101_SEQ_2336
Figure 12_A0101_SEQ_2337
Figure 12_A0101_SEQ_2338
Figure 12_A0101_SEQ_2339
Figure 12_A0101_SEQ_2340
Figure 12_A0101_SEQ_2341
Figure 12_A0101_SEQ_2342
Figure 12_A0101_SEQ_2343
Figure 12_A0101_SEQ_2344
Figure 12_A0101_SEQ_2345
Figure 12_A0101_SEQ_2346
Figure 12_A0101_SEQ_2347
Figure 12_A0101_SEQ_2348
Figure 12_A0101_SEQ_2349
Figure 12_A0101_SEQ_2350
Figure 12_A0101_SEQ_2351
Figure 12_A0101_SEQ_2352
Figure 12_A0101_SEQ_2353
Figure 12_A0101_SEQ_2354
Figure 12_A0101_SEQ_2355
Figure 12_A0101_SEQ_2356
Figure 12_A0101_SEQ_2357
Figure 12_A0101_SEQ_2358
Figure 12_A0101_SEQ_2359
Figure 12_A0101_SEQ_2360
Figure 12_A0101_SEQ_2361
Figure 12_A0101_SEQ_2362
Figure 12_A0101_SEQ_2363
Figure 12_A0101_SEQ_2364
Figure 12_A0101_SEQ_2365
Figure 12_A0101_SEQ_2366
Figure 12_A0101_SEQ_2367
Figure 12_A0101_SEQ_2368
Figure 12_A0101_SEQ_2369
Figure 12_A0101_SEQ_2370
Figure 12_A0101_SEQ_2371
Figure 12_A0101_SEQ_2372
Figure 12_A0101_SEQ_2373
Figure 12_A0101_SEQ_2374
Figure 12_A0101_SEQ_2375
Figure 12_A0101_SEQ_2376
Figure 12_A0101_SEQ_2377
Figure 12_A0101_SEQ_2378
Figure 12_A0101_SEQ_2379
Figure 12_A0101_SEQ_2380
Figure 12_A0101_SEQ_2381
Figure 12_A0101_SEQ_2382
Figure 12_A0101_SEQ_2383
Figure 12_A0101_SEQ_2384
Figure 12_A0101_SEQ_2385
Figure 12_A0101_SEQ_2386
Figure 12_A0101_SEQ_2387
Figure 12_A0101_SEQ_2388
Figure 12_A0101_SEQ_2389
Figure 12_A0101_SEQ_2390
Figure 12_A0101_SEQ_2391
Figure 12_A0101_SEQ_2392
Figure 12_A0101_SEQ_2393
Figure 12_A0101_SEQ_2394
Figure 12_A0101_SEQ_2395
Figure 12_A0101_SEQ_2396
Figure 12_A0101_SEQ_2397
Figure 12_A0101_SEQ_2398
Figure 12_A0101_SEQ_2399
Figure 12_A0101_SEQ_2400
Figure 12_A0101_SEQ_2401
Figure 12_A0101_SEQ_2402
Figure 12_A0101_SEQ_2403
Figure 12_A0101_SEQ_2404
Figure 12_A0101_SEQ_2405
Figure 12_A0101_SEQ_2406
Figure 12_A0101_SEQ_2407
Figure 12_A0101_SEQ_2408
Figure 12_A0101_SEQ_2409
Figure 12_A0101_SEQ_2410
Figure 12_A0101_SEQ_2411
Figure 12_A0101_SEQ_2412
Figure 12_A0101_SEQ_2413
Figure 12_A0101_SEQ_2414
Figure 12_A0101_SEQ_2415
Figure 12_A0101_SEQ_2416
Figure 12_A0101_SEQ_2417
Figure 12_A0101_SEQ_2418
Figure 12_A0101_SEQ_2419
Figure 12_A0101_SEQ_2420
Figure 12_A0101_SEQ_2421
Figure 12_A0101_SEQ_2422
Figure 12_A0101_SEQ_2423
Figure 12_A0101_SEQ_2424
Figure 12_A0101_SEQ_2425
Figure 12_A0101_SEQ_2426
Figure 12_A0101_SEQ_2427
Figure 12_A0101_SEQ_2428
Figure 12_A0101_SEQ_2429
Figure 12_A0101_SEQ_2430
Figure 12_A0101_SEQ_2431
Figure 12_A0101_SEQ_2432
Figure 12_A0101_SEQ_2433
Figure 12_A0101_SEQ_2434
Figure 12_A0101_SEQ_2435
Figure 12_A0101_SEQ_2436
Figure 12_A0101_SEQ_2437
Figure 12_A0101_SEQ_2438
Figure 12_A0101_SEQ_2439
Figure 12_A0101_SEQ_2440
Figure 12_A0101_SEQ_2441
Figure 12_A0101_SEQ_2442
Figure 12_A0101_SEQ_2443
Figure 12_A0101_SEQ_2444
Figure 12_A0101_SEQ_2445
Figure 12_A0101_SEQ_2446
Figure 12_A0101_SEQ_2447
Figure 12_A0101_SEQ_2448
Figure 12_A0101_SEQ_2449
Figure 12_A0101_SEQ_2450
Figure 12_A0101_SEQ_2451
Figure 12_A0101_SEQ_2452
Figure 12_A0101_SEQ_2453
Figure 12_A0101_SEQ_2454
Figure 12_A0101_SEQ_2455
Figure 12_A0101_SEQ_2456
Figure 12_A0101_SEQ_2457
Figure 12_A0101_SEQ_2458
Figure 12_A0101_SEQ_2459
Figure 12_A0101_SEQ_2460
Figure 12_A0101_SEQ_2461
Figure 12_A0101_SEQ_2462
Figure 12_A0101_SEQ_2463
Figure 12_A0101_SEQ_2464
Figure 12_A0101_SEQ_2465
Figure 12_A0101_SEQ_2466
Figure 12_A0101_SEQ_2467
Figure 12_A0101_SEQ_2468
Figure 12_A0101_SEQ_2469
Figure 12_A0101_SEQ_2470
Figure 12_A0101_SEQ_2471
Figure 12_A0101_SEQ_2472
Figure 12_A0101_SEQ_2473
Figure 12_A0101_SEQ_2474
Figure 12_A0101_SEQ_2475
Figure 12_A0101_SEQ_2476
Figure 12_A0101_SEQ_2477
Figure 12_A0101_SEQ_2478
Figure 12_A0101_SEQ_2479
Figure 12_A0101_SEQ_2480
Figure 12_A0101_SEQ_2481
Figure 12_A0101_SEQ_2482
Figure 12_A0101_SEQ_2483
Figure 12_A0101_SEQ_2484
Figure 12_A0101_SEQ_2485
Figure 12_A0101_SEQ_2486
Figure 12_A0101_SEQ_2487
Figure 12_A0101_SEQ_2488
Figure 12_A0101_SEQ_2489
Figure 12_A0101_SEQ_2490
Figure 12_A0101_SEQ_2491
Figure 12_A0101_SEQ_2492
Figure 12_A0101_SEQ_2493
Figure 12_A0101_SEQ_2494
Figure 12_A0101_SEQ_2495
Figure 12_A0101_SEQ_2496
Figure 12_A0101_SEQ_2497
Figure 12_A0101_SEQ_2498
Figure 12_A0101_SEQ_2499
Figure 12_A0101_SEQ_2500
Figure 12_A0101_SEQ_2501
Figure 12_A0101_SEQ_2502
Figure 12_A0101_SEQ_2503
Figure 12_A0101_SEQ_2504
Figure 12_A0101_SEQ_2505
Figure 12_A0101_SEQ_2506
Figure 12_A0101_SEQ_2507
Figure 12_A0101_SEQ_2508
Figure 12_A0101_SEQ_2509
Figure 12_A0101_SEQ_2510
Figure 12_A0101_SEQ_2511
Figure 12_A0101_SEQ_2512
Figure 12_A0101_SEQ_2513
Figure 12_A0101_SEQ_2514
Figure 12_A0101_SEQ_2515
Figure 12_A0101_SEQ_2516
Figure 12_A0101_SEQ_2517
Figure 12_A0101_SEQ_2518
Figure 12_A0101_SEQ_2519
Figure 12_A0101_SEQ_2520
Figure 12_A0101_SEQ_2521
Figure 12_A0101_SEQ_2522
Figure 12_A0101_SEQ_2523
Figure 12_A0101_SEQ_2524
Figure 12_A0101_SEQ_2525
Figure 12_A0101_SEQ_2526
Figure 12_A0101_SEQ_2527
Figure 12_A0101_SEQ_2528
Figure 12_A0101_SEQ_2529
Figure 12_A0101_SEQ_2530
Figure 12_A0101_SEQ_2531
Figure 12_A0101_SEQ_2532
Figure 12_A0101_SEQ_2533
Figure 12_A0101_SEQ_2534
Figure 12_A0101_SEQ_2535
Figure 12_A0101_SEQ_2536
Figure 12_A0101_SEQ_2537
Figure 12_A0101_SEQ_2538
Figure 12_A0101_SEQ_2539
Figure 12_A0101_SEQ_2540
Figure 12_A0101_SEQ_2541
Figure 12_A0101_SEQ_2542
Figure 12_A0101_SEQ_2543
Figure 12_A0101_SEQ_2544
Figure 12_A0101_SEQ_2545
Figure 12_A0101_SEQ_2546
Figure 12_A0101_SEQ_2547
Figure 12_A0101_SEQ_2548
Figure 12_A0101_SEQ_2549
Figure 12_A0101_SEQ_2550
Figure 12_A0101_SEQ_2551
Figure 12_A0101_SEQ_2552
Figure 12_A0101_SEQ_2553
Figure 12_A0101_SEQ_2554
Figure 12_A0101_SEQ_2555
Figure 12_A0101_SEQ_2556
Figure 12_A0101_SEQ_2557
Figure 12_A0101_SEQ_2558
Figure 12_A0101_SEQ_2559
Figure 12_A0101_SEQ_2560
Figure 12_A0101_SEQ_2561
Figure 12_A0101_SEQ_2562
Figure 12_A0101_SEQ_2563
Figure 12_A0101_SEQ_2564
Figure 12_A0101_SEQ_2565
Figure 12_A0101_SEQ_2566
Figure 12_A0101_SEQ_2567
Figure 12_A0101_SEQ_2568
Figure 12_A0101_SEQ_2569
Figure 12_A0101_SEQ_2570
Figure 12_A0101_SEQ_2571
Figure 12_A0101_SEQ_2572
Figure 12_A0101_SEQ_2573
Figure 12_A0101_SEQ_2574
Figure 12_A0101_SEQ_2575
Figure 12_A0101_SEQ_2576
Figure 12_A0101_SEQ_2577
Figure 12_A0101_SEQ_2578
Figure 12_A0101_SEQ_2579
Figure 12_A0101_SEQ_2580
Figure 12_A0101_SEQ_2581
Figure 12_A0101_SEQ_2582
Figure 12_A0101_SEQ_2583
Figure 12_A0101_SEQ_2584
Figure 12_A0101_SEQ_2585
Figure 12_A0101_SEQ_2586
Figure 12_A0101_SEQ_2587
Figure 12_A0101_SEQ_2588
Figure 12_A0101_SEQ_2589
Figure 12_A0101_SEQ_2590
Figure 12_A0101_SEQ_2591
Figure 12_A0101_SEQ_2592
Figure 12_A0101_SEQ_2593
Figure 12_A0101_SEQ_2594
Figure 12_A0101_SEQ_2595
Figure 12_A0101_SEQ_2596
Figure 12_A0101_SEQ_2597
Figure 12_A0101_SEQ_2598
Figure 12_A0101_SEQ_2599
Figure 12_A0101_SEQ_2600
Figure 12_A0101_SEQ_2601
Figure 12_A0101_SEQ_2602

Claims (103)

  1. 一種經修飾重組酶,其包含第一區段及第二區段,其中: 該第一區段包含對應於第一參考區段之胺基酸序列,該第一參考區段含有SEQ ID NO: 2之胺基酸197至271,其中該第一區段之胺基酸序列與該第一參考區段之胺基酸序列至少80%、80至90%、90至95%或至少95%一致,且其中該第一區段具有高於該第一參考區段之等電點;及 該第二區段包含對應於第二參考區段之胺基酸序列,該第二參考區段含有SEQ ID NO: 2之胺基酸443至528,其中該第二區段之胺基酸序列與該第二參考區段之胺基酸序列至少80%、80至90%、90至95%或至少95%一致,且其中該第二區段具有高於該第二參考區段之等電點。
  2. 一種包含第一區段之經修飾重組酶,該第一區段包含對應於參考區段之胺基酸序列,該參考區段含有SEQ ID NO: 2之胺基酸1至196,其中該第一區段之胺基酸序列與該參考區段之胺基酸序列至少80%、80至90%、90至95%或至少95%一致;且其中該第一區段具有高於該參考區段之等電點。
  3. 一種經修飾重組酶,其包含第一區段及第二區段,其中: 該第一區段包含對應於第一參考區段之胺基酸序列,該第一參考區段含有SEQ ID NO: 2之胺基酸1至271,其中該第一區段之胺基酸序列與該第一參考區段之胺基酸序列至少80%、80至90%、90至95%或至少95%一致,且其中該第一區段具有高於該第一參考區段之等電點;及 該第二區段包含對應於第二參考區段之胺基酸序列,該第二參考區段含有SEQ ID NO: 2之胺基酸443至528,其中該第二區段之胺基酸序列與該第二參考區段之胺基酸序列至少80%、80至90%、90至95%或至少95%一致,且其中該第二區段具有高於該第二參考區段之等電點。
  4. 如請求項1至3中任一項之經修飾重組酶,其中該經修飾重組酶之胺基酸序列包含對應於SEQ ID NO: 2之以下之一或多個位置處之修飾: K4、T13、S22、V25、C26、D27、N33、I34、F36、S42、D54、N59、E60、E65、E85、M95、N106、T110、T114、K119、Q122、Y133、P136、E139、E142、N145、P147、I148、E152、I153、P160、D167、D171、N175、F188、D189、Q206、T211、S216、R217、D232、A236、V247、I253、V261、L264、S267、V443、L445、A446、S447、V449、T450、W452、G453、Y455、F465、N467、T479、E482、A484、E485、A486、L490、D492、S493、K495、K500、S503、Q506、Q513、E519、D521、E523及V526。
  5. 如請求項4之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:K4R、T13N、S22A、V25L、C26W、D27E、N33T、I34V、F36V、S42T、D54Y、N59D、E60L、E60V、E65S、E85P、M95T、M95K、N106G、T110I、T114S、K119Q、Q122V、Y133L、P136T、E139K、E139Q、E139R、E139H、E142K、E142Q、E142R、E142H、N145K、N145H、N145R、P147Q、P147T、I148K、I148H、I148R、E152D、I153V、P160A、D167P、D167K、D167H、D167R、D171K、D171H、D171R、N175T、N175Y、F188C、D189K、D189H、D189R、Q206R、Q206K、Q206H、T211A、S216G、S216R、R217G、D232K、A236G、V247D、I253H、I253A、V261A、V261I、V261L、L264H、L264A、L264M、S267A、V443T、L445M、A446G、S447V、V449I、T450A、W452Y、G453A、Y455W、F465Y、N467R、N467K、N467H、N467S、N467T、T479V、E482K、E482H、E482R、A484E、E485D、A486E、L490M、D492H、D492K、D492R、D492A、H492S、S493P、K495R、K500E、S503A、S503T、Q506K、Q513D、D521K、D521R、D521H、E523R、E523V、E523Y、E523F、E523H、E523W及V526L。
  6. 如請求項3或4之經修飾重組酶,其中該經修飾重組酶之胺基酸序列包含對應於以下之一或多個位置處之修飾:E139、E142、N145、I148、D167、D171、D189、N467、E482、D492、K495、D521及E523。
  7. 如請求項6之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:E139K、E139Q、E139R、E139H、E142K、E142H、E142R、E142Q、N145K、N145H、N145R、I148K、I148H、I148R、D167P、D167K、D167H、D167R、D171K、D171H、D171R、D189K、D189H、D189R、N467R、N467K、N467H、N467S、N467T、E482K、E482H、E482R、D492H、D492K、D492R、K495R、D521K、D521H、D521R、E523K、E523Y、E523H、E523R、E523F及E523W。
  8. 如請求項1至7中任一項之經修飾重組酶,其中該經修飾重組酶之胺基酸序列包含對應於SEQ ID NO: 2之以下之一或多個位置處之修飾: P273、P275、R308、V315、Q317、S319、L320、I322、Q323、D337、E338、D341、T345、F352、F353、T364、D374、I384、E385、N388、E391、A396、N397、G400、D414、D425、R429、E436、L437、D533、R534、E537、G547、E545、L555、P556、R558、T559、V564、T568、M569及T571。
  9. 如請求項8之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:P273S、P273R、P275S、E283K、V315L、S319R、R308G、G308R、Q317R、S319R、L320M、L320T、I322K、Q323G、Q323V、Q323R、D337G、E338K、D341T、T345I、F352I、F353C、T364I、D374G、D374Q、D374H、I384T、I384F、I384S、E385Y、E385K、E385R、E385N、E385Q、E385L、E385A、N388T、E391Y、E391W、E391F、E391H、E391M、E391K、E391R、A396Q、N397L、G400L、D414V、D425N、R429G、E436R、E436G、L437Y、L437E、D533A、D533Q、D533T、D533R、D533S、R534K、E537K、E537H、E537R、E545K、E545H、E545R、G547S、L555K、L555R、P556A、R558H、T559V、V564L、T568D、T568S、M569K、M569T、M569V及T571S。
  10. 如請求項8之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:D374G、D374Q、D374H、E385Y、E385K、E385R、E385N、E385Q、E385L、E385A、E391Y、E391W、E391K、E391F、D533A、D533Q、D533T、D533R、D533S、E537K、E537H、E537R、E545K、E545H及E545R。
  11. 如請求項8至10中任一項之經修飾重組酶,其中該經修飾重組酶包含表7中所列之修飾之組合。
  12. 如請求項1至11中任一項之經修飾重組酶,其中該經修飾重組酶之胺基酸序列包含對應於SEQ ID NO: 2之以下之一或多個位置處之修飾: E142、I148、D189、V261、L264、R308、E391、E482、D492、K500、D521、E523及E537。
  13. 如請求項12之經修飾重組酶,其中: 位置E142處之修飾為E142K; 位置I148處之修飾為I148K; 位置D189處之修飾為D189K; 位置V261處之修飾為V261A; 位置L264處之修飾為L264H; 位置R308處之修飾為R308G; 位置E391處之修飾為E391Y; 位置E482處之修飾為E482K; 位置D492之修飾為D492H; 位置K500處之修飾為K500E; 位置D521處之修飾為D521K; 位置E523處之修飾為E523K;及 位置E537處之修飾為E537K。
  14. 如請求項13之經修飾重組酶,其中該經修飾重組酶包含SEQ ID NO: 88之胺基酸序列。
  15. 如請求項13之經修飾重組酶,其中該經修飾重組酶之胺基酸序列包含位置E60處之修飾。
  16. 如請求項15之經修飾重組酶,其中E60處之修飾為E60L。
  17. 如請求項16之經修飾重組酶,其中該經修飾重組酶包含SEQ ID NO: 157之胺基酸序列。
  18. 如請求項17之經修飾重組酶,其中該經修飾重組酶進一步包含雙生物素標籤。
  19. 如請求項18之經修飾重組酶,其中該經修飾重組酶包含SEQ ID NO: 180之胺基酸序列。
  20. 一種經修飾重組酶,其包含一或多個選自以下之區段: 具有與SEQ ID NO: 2之胺基酸1至196至少80%、80至90%、90至95%或至少95%一致之胺基酸序列的第一區段,其中該第一區段之胺基酸序列包含對應於SEQ ID NO: 2之以下之一或多個位置處之修飾: K4、T13、S22、V25、C26、D27、N33、I34、F36、S42、D54、N59、E60、E65、E85、M95、N106、T110、T114、K119、Q122、Y133、P136、E139、E142、N145、P147、I148、E152、I153、P160、D167、D171、N175、F188及D189; 具有與SEQ ID NO: 2之胺基酸197至271至少80%、80至90%、90至95%或至少95%一致之胺基酸序列的第二區段,其中該第二區段之胺基酸序列包含對應於SEQ ID NO: 2之以下之一或多個位置處之修飾: Q206、T211、S216、R217、D232、A236、V247、I253、V261、L264及S267;及/或 具有與SEQ ID NO: 2之胺基酸443至528至少80%、80至90%、90至5%或至少95%一致之胺基酸序列的第三區段,其中該第三區段之胺基酸序列包含對應於SEQ ID NO: 2之以下之一或多個位置處之修飾: V443、L445、A446、S447、V449、T450、W452、G453、Y455、F465、N467、T479、E482、A484、E485、A486、L490、D492、S493、K495、K500、S503、Q506、Q513、E519、D521、E523及V526。
  21. 如請求項20之經修飾重組酶,其中該經修飾重組酶包含該第一區段及該第二區段。
  22. 如請求項20之經修飾重組酶,其中該經修飾重組酶包含該第二區段及該第三區段。
  23. 如請求項20之經修飾重組酶,其中該經修飾重組酶包含該第一區段及該第三區段。
  24. 如請求項20之經修飾重組酶,其中該經修飾重組酶包含該第一區段、該第二區段及該第三區段。
  25. 如請求項20至24中任一項之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:K4R、T13N、S22A、V25L、C26W、D27E、N33T、I34V、F36V、S42T、D54Y、N59D、E60L、E60V、E65S、E85P、M95T、M95K、N106G、T110I、T114S、K119Q、Q122V、Y133L、P136T、E139K、E139Q、E139R、E139H、E142K、E142Q、E142R、E142H、N145K、N145H、N145R、P147Q、P147T、I148K、I148H、I148R、E152D、I153V、P160A、D167P、D167K、D167H、D167R、D171K、D171H、D171R、N175T、N175Y、F188C、D189K、D189H、D189R、Q206R、Q206K、Q206H、T211A、S216G、S216R、R217G、D232K、A236G、V247D、I253H、I253A、V261A、V261I、V261L、L264H、L264A、L264M、S267A、V443T、L445M、A446G、S447V、V449I、T450A、W452Y、G453A、Y455W、F465Y、N467R、N467K、N467H、N467S、N467T、T479V、E482K、E482H、E482R、A484E、E485D、A486E、L490M、D492H、D492K、D492R、D492A、H492S、S493P、K495R、K500E、S503A、S503T、Q506K、Q513D、D521K、D521R、D521H、E523R、E523V、E523Y、E523F、E523H、E523W及V526L。
  26. 如請求項20至25中任一項之經修飾重組酶,其中該經修飾重組酶之胺基酸序列包含對應於以下之一或多個位置處之修飾:E139、E142、N145、I148、D167、D171、D189、N467、E482、D492、K495、D521及E523。
  27. 如請求項26之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:E139K、E139Q、E139R、E139H、E142K、E142H、E142R、E142Q、N145K、N145H、N145R、I148K、I148H、I148R、D167P、D167K、D167H、D167R、D171K、D171H、D171R、D189K、D189H、D189R、N467R、N467K、N467H、N467S、N467T、E482K、E482H、E482R、D492H、D492K、D492R、K495R、D521K、D521H、D521R、E523K、E523Y、E523H、E523R、E523F及E523W。
  28. 如請求項20至27中任一項之經修飾重組酶,其中該經修飾重組酶之胺基酸序列包含對應於SEQ ID NO: 2之以下之一或多個位置處之修飾: P273、P275、R308、V315、Q317、S319、L320、I322、Q323、D337、E338、D341、T345、F352、F353、T364、D374、I384、E385、N388、E391、A396、N397、G400、D414、D425、R429、E436、L437、D533、R534、E537、G547、E545、L555、P556、R558、T559、V564、T568、M569及T571。
  29. 如請求項28之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:P273S、P273R、P275S、E283K、V315L、S319R、R308G、G308R、Q317R、S319R、L320M、L320T、I322K、Q323G、Q323V、Q323R、D337G、E338K、D341T、T345I、F352I、F353C、T364I、D374G、D374Q、D374H、I384T、I384F、I384S、E385Y、E385K、E385R、E385N、E385Q、E385L、E385A、N388T、E391Y、E391W、E391F、E391H、E391M、E391K、E391R、A396Q、N397L、G400L、D414V、D425N、R429G、E436R、E436G、L437Y、L437E、D533A、D533Q、D533T、D533R、D533S、R534K、E537K、E537H、E537R、E545K、E545H、E545R、G547S、L555K、L555R、P556A、R558H、T559V、V564L、T568D、T568S、M569K、M569T、M569V及T571S。
  30. 如請求項28之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:D374G、D374Q、D374H、E385Y、E385K、E385R、E385N、E385Q、E385L、E385A、E391Y、E391W、E391K、E391F、D533A、D533Q、D533T、D533R、D533S、E537K、E537H、E537R、E545K、E545H、E545R。
  31. 如請求項28至30中任一項之經修飾重組酶,其中該經修飾重組酶包含表7中所列之修飾之組合。
  32. 如請求項20至31中任一項之經修飾重組酶,其中該經修飾重組酶之胺基酸序列包含對應於SEQ ID NO: 2之以下之一或多個位置處之修飾: E142、I148、D189、V261、L264、R308、E391、E482、D492、K500、D521、E523及E537。
  33. 如請求項32之經修飾重組酶,其中: 位置E142處之修飾為E142K; 位置I148處之修飾為I148K; 位置D189處之修飾為D189K; 位置V261處之修飾為V261A; 位置L264處之修飾為L264H; 位置R308處之修飾為R308G; 位置E391處之修飾為E391Y; 位置E482處之修飾為E482K; 位置D492之修飾為D492H; 位置K500處之修飾為K500E; 位置D521處之修飾為D521K; 位置E523處之修飾為E523K;及 位置E537處之修飾為E537K。
  34. 如請求項33之經修飾重組酶,其中該經修飾重組酶包含SEQ ID NO: 88之胺基酸序列。
  35. 如請求項33之經修飾重組酶,其中該經修飾重組酶之胺基酸序列包含位置E60處之修飾。
  36. 如請求項35之經修飾重組酶,其中E60處之修飾為E60L。
  37. 如請求項36之經修飾重組酶,其中該經修飾重組酶包含SEQ ID NO: 157之胺基酸序列。
  38. 如請求項36之經修飾重組酶,其中該經修飾重組酶進一步包含雙生物素標籤。
  39. 如請求項38之經修飾重組酶,其中該經修飾重組酶包含SEQ ID NO: 180之胺基酸序列。
  40. 一種經修飾重組酶,其包含含有以下之胺基酸序列:(i)第一區段、第二區段、第三區段、第四區段、第五區段、第六區段及第七區段;及(ii)在對應於SEQ ID NO: 2之E139、E142、N145、I148、D167、D171、D189、D374、E385、E391、N467、E482、D492、K495、D521、E523、D533、E537及E545之一或多個位置處之修飾;其中 該第一區段包含與表1、表2或表3之聚合酶之外切核酸酶區域至少80%、80至90%、90至95%或至少95%一致的胺基酸序列; 該第二區段及該第六區段共同包含與表1、表2或表3之聚合酶之掌型區域至少80%、80至90%、90至95%或至少95%一致的胺基酸序列; 該第三區段包含與表1、表2或表3之聚合酶之TPR1區域至少80%、80至90%、90至95%或至少95%一致的胺基酸序列; 該第四區段包含與表1、表2或表3之聚合酶之手指型區域至少80%、80至90%、90至95%或至少95%一致的胺基酸序列; 該第五區段包含與表1、表2或表3之聚合酶之TPR2區域至少80%、80至90%、90至95%或至少95%一致的胺基酸序列;及 該第七區段包含與表1、表2或表3之聚合酶之拇指型區域至少80%、80至90%、90至95%或至少95%一致的胺基酸序列。
  41. 如請求項40之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:E139K、E139Q、E139R、E139H、E142K、E142H、E142R、E142Q、N145K、N145H、N145R、I148K、I148H、I148R、D167P、D167K、D167H、D167R、D171K、D171H、D171R、D189K、D189H、D189R、D374G、D374Q、D374H、E385Y、E385K、E385R、E385N、E385Q、E385L、E385A、E391Y、E391W、E391K、E391F、N467R、N467K、N467H、N467S、N467T、E482K、E482H、E482R、D492H、D492K、D492R、K495R、D521K、D521H、D521R、E523K、E523Y、E523H、E523R、E523F、E523W、D533A、D533Q、D533T、D533R、D533S、E537K、E537H、E537R、E545K、E545H、E545R。
  42. 如請求項40或41之經修飾重組酶,其進一步包含對應於以下之一或多個位置處之修飾:SEQ ID NO: 2之K4、T13、S22、V25、C26、D27、N33、I34、F36、S42、D54、N59、E60、E65、E85、M95、N106、T110、T114、K119、Q122、Y133、P136、P147、E152、I153、P160、N175、F188、Q206、T211、S216、R217、D232、A236、V247、I253、V261、L264、S267、P273、P275、R308、V315、Q317、S319、L320、I322、Q323、D337、E338、D341、T345、F352、F353、T364、I384、N388、A396、N397、G400、D414、D425、R429、E436、L437、V443、L445、A446、S447、V449、T450、W452、G453、Y455、F465、T479、A484、E485、A486、L490、S493、K500、S503、Q506、Q513、E519、V526、R534、G547、L555、P556、R558、T559、V564、T568、M569及T571。
  43. 如請求項42之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:K4R、T13N、S22A、V25L、C26W、D27E、N33T、I34V、F36V、S42T、D54Y、N59D、E60L、E60V、E65S、E85P、M95T、M95K、N106G、T110I、T114S、K119Q、Q122V、Y133L、P136T、P147Q、P147T、E152D、I153V、P160A、N175T、N175Y、F188C、Q206R、Q206K、Q206H、T211A、S216G、S216R、R217G、D232K、A236G、V247D、I253H、I253A、V261A、V261I、V261L、L264H、L264A、L264M、S267A、P273S、P273R、P275S、E283K、V315L、S319R、R308G、G308R、Q317R、S319R、L320M、L320T、I322K、Q323G、Q323V、Q323R、D337G、E338K、D341T、T345I、F352I、F353C、T364I、I384T、I384F、I384S、N388T、A396Q、N397L、G400L、D414V、D425N、R429G、E436R、E436G、L437Y、L437E、V443T、L445M、A446G、S447V、V449I、T450A、W452Y、G453A、Y455W、F465Y、T479V、A484E、E485D、A486E、L490M、S493P、K500E、S503A、S503T、Q506K、Q513D、V526L、R534K、G547S、L555K、L555R、P556A、R558H、T559V、V564L、T568D、T568S、M569K、M569T、M569V及T571S。
  44. 如請求項42或43之經修飾重組酶,其中該經修飾重組酶包含表7中所列之修飾之組合。
  45. 一種經修飾重組酶,其包含: 與SEQ ID NO: 2至少60%、60至70%、70至80%或至少80%一致的胺基酸序列;及 延長掌型域,其中該延長掌型域包含與SEQ ID NO: 1之胺基酸505至524至少80%、80至90%、90至95%或至少95%一致之胺基酸序列之添加。
  46. 如請求項45之經修飾重組酶,其進一步包含對應於以下之一或多個位置處之修飾:SEQ ID NO: 2之K4、T13、S22、V25、C26、D27、N33、I34、F36、S42、D54、N59、E60、E65、E85、M95、N106、T110、T114、K119、Q122、Y133、P136、E139、E142、N145、P147、I148、E152、I153、P160、D167、D171、N175、F188、D189、Q206、T211、S216、R217、D232、A236、V247、I253、V261、L264、S267、V443、L445、A446、S447、V449、T450、W452、G453、Y455、F465、N467、T479、E482、A484、E485、A486、L490、D492、S493、K495、K500、S503、Q506、Q513、E519、D521、E523及V526。
  47. 如請求項46之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:K4R、T13N、S22A、V25L、C26W、D27E、N33T、I34V、F36V、S42T、D54Y、N59D、E60L、E60V、E65S、E85P、M95T、M95K、N106G、T110I、T114S、K119Q、Q122V、Y133L、P136T、E139K、E139Q、E139R、E139H、E142K、E142Q、E142R、E142H、N145K、N145H、N145R、P147Q、P147T、I148K、I148H、I148R、E152D、I153V、P160A、D167P、D167K、D167H、D167R、D171K、D171H、D171R、N175T、N175Y、F188C、D189K、D189H、D189R、Q206R、Q206K、Q206H、T211A、S216G、S216R、R217G、D232K、A236G、V247D、I253H、I253A、V261A、V261I、V261L、L264H、L264A、L264M、S267A、V443T、L445M、A446G、S447V、V449I、T450A、W452Y、G453A、Y455W、F465Y、N467R、N467K、N467H、N467S、N467T、T479V、E482K、E482H、E482R、A484E、E485D、A486E、L490M、D492H、D492K、D492R、D492A、H492S、S493P、K495R、K500E、S503A、S503T、Q506K、Q513D、D521K、D521R、D521H、E523R、E523V、E523Y、E523F、E523H、E523W及V526L。
  48. 如請求項46或47之經修飾重組酶,其中該經修飾重組酶之胺基酸序列進一步包含對應於以下之一或多個位置處之修飾:E139、E142、N145、I148、D167、D171、D189、N467、E482、D492、K495、D521及E523。
  49. 如請求項48之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:E139K、E139Q、E139R、E139H、E142K、E142H、E142R、E142Q、N145K、N145H、N145R、I148K、I148H、I148R、D167P、D167K、D167H、D167R、D171K、D171H、D171R、D189K、D189H、D189R、N467R、N467K、N467H、N467S、N467T、E482K、E482H、E482R、D492H、D492K、D492R、K495R、D521K、D521H、D521R、E523K、E523Y、E523H、E523R、E523F及E523W。
  50. 如請求項46至49中任一項之經修飾重組酶,其中該經修飾重組酶之胺基酸序列包含對應於SEQ ID NO: 2之以下之一或多個位置處之修飾: P273、P275、R308、V315、Q317、S319、L320、I322、Q323、D337、E338、D341、T345、F352、F353、T364、D374、I384、E385、N388、E391、A396、N397、G400、D414、D425、R429、E436、L437、D533、R534、E537、G547、E545、L555、P556、R558、T559、V564、T568、M569及T571。
  51. 如請求項50之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:P273S、P273R、P275S、E283K、V315L、S319R、R308G、G308R、Q317R、S319R、L320M、L320T、I322K、Q323G、Q323V、Q323R、D337G、E338K、D341T、T345I、F352I、F353C、T364I、D374G、D374Q、D374H、I384T、I384F、I384S、E385Y、E385K、E385R、E385N、E385Q、E385L、E385A、N388T、E391Y、E391W、E391F、E391H、E391M、E391K、E391R、A396Q、N397L、G400L、D414V、D425N、R429G、E436R、E436G、L437Y、L437E、D533A、D533Q、D533T、D533R、D533S、R534K、E537K、E537H、E537R、E545K、E545H、E545R、G547S、L555K、L555R、P556A、R558H、T559V、V564L、T568D、T568S、M569K、M569T、M569V及T571S。
  52. 如請求項50之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:D374G、D374Q、D374H、E385Y、E385K、E385R、E385N、E385Q、E385L、E385A、E391Y、E391W、E391K、E391F、D533A、D533Q、D533T、D533R、D533S、E537K、E537H、E537R、E545K E545H、E545R。
  53. 如請求項50至52中任一項之經修飾重組酶,其中該經修飾重組酶包含表7中所列之修飾之組合。
  54. 一種經修飾重組酶,其具有與SEQ ID NO: 1至33中之任一者至少60%、60至70%、70至80%或至少80%一致之胺基酸序列,其中該胺基酸序列包含對應於屎腸球菌(E. faecium )聚合酶(SEQ ID NO: 2)之以下之一或多個位置處之修飾: K4、T13、S22、V25、C26、D27、N33、I34、F36、S42、D54、N59、E60、E65、E85、M95、N106、T110、T114、K119、Q122、Y133、P136、E139、E142、N145、P147、I148、E152、I153、P160、D167、D171、N175、F188、D189、Q206、T211、S216、R217、D232、A236、V247、I253、V261、L264、S267、P273、P275、R308、V315、Q317、S319、L320、I322、Q323、D337、E338、D341、T345、F352、F353、T364、D374、I384、E385、N388、E391、A396、N397、G400、D414、D425、R429、E436、L437、V443、L445、A446、S447、V449、T450、W452、G453、Y455、F465、N467、T479、E482、A484、E485、A486、L490、D492、S493、K495、K500、S503、Q506、Q513、E519、D521、E523、V526、D533、R534、E537、G547、E545、L555、P556、R558、T559、V564、T568、M569及T571。
  55. 如請求項54之經修飾重組酶,其包含對應於SEQ ID NO: 2之T568及M569的一個或兩個位置處之修飾。
  56. 如請求項55之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:T568D、T568S、M569T及M569V。
  57. 如請求項55或請求項56之經修飾重組酶,其中該經修飾重組酶相對於屎腸球菌聚合酶(SEQ ID NO: 2)具有改良之持續效力。
  58. 如請求項54至57中任一項之經修飾重組酶,其包含對應於SEQ ID NO: 2之N59的位置處之修飾。
  59. 如請求項58之經修飾重組酶,其中該修飾為N59D。
  60. 如請求項58或請求項59之經修飾重組酶,其中該經修飾重組酶相對於屎腸球菌聚合酶(SEQ ID NO: 2)具有改變之外切核酸酶活性。
  61. 如請求項54至60中任一項之經修飾重組酶,其包含一或多個對應於SEQ ID NO: 2之V261、L264、S267、I384、E391、W452、G453、Y455、D492及K500的位置處之修飾。
  62. 如請求項61之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:V261A、V261I、L264A、L264H、L264M、S267A、I384F、I384S、E391Y、E391W、E391F、E391H、E391M、E391K、E391R、W452Y、G453A、Y455W、D492H及K500E。
  63. 如請求項61或請求項62之經修飾重組酶,其中該經修飾重組酶相對於屎腸球菌聚合酶(SEQ ID NO: 2)具有改良之核苷酸受質利用率。
  64. 如請求項54至63中任一項之經修飾重組酶,其包含對應於SEQ ID NO: 2之以下之一或多個位置處之修飾: E65、Y133、V261、L264、S267、I384、E391、G400、V443、L445、A446、S447、V449、T450、W452、G453、Y455、K500、S503、E523、L555及P556。
  65. 如請求項64之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:E65S、Y133L、V261A、V261I、L264A、L264H、S267A、I384F、I384S、E391Y、E391W、E391F、E391K、G400L、V443T、L445M、A446G、S447V、V449I、T450A、W452Y、G453A、Y455W、K500E、S503A、E523K、E523Y、E523F、E523H、E523W、L555K及P556A。
  66. 如請求項64或請求項65之經修飾重組酶,其中該經修飾重組酶相對於屎腸球菌聚合酶(SEQ ID NO: 2)具有改良之精確度。
  67. 如請求項54至66中任一項之經修飾重組酶,其包含一或多個對應於SEQ ID NO: 2之Q317、S319、I322、Q323、R429、L555及T559的位置處之修飾。
  68. 如請求項67之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:Q317R、S319R、I322K、Q323G、R429G、L555K及T559V。
  69. 如請求項67或請求項68之經修飾重組酶,其中該經修飾重組酶相對於屎腸球菌聚合酶(SEQ ID NO: 2)具有增加之DNA結合親和力。
  70. 如請求項54至69中任一項之經修飾重組酶,其包含一或多個對應於SEQ ID NO: 2之E391、S503及E523的位置處之修飾。
  71. 如請求項70之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:E391Y、E391W、E391F、E391K、S503A、E523K、E523Y、E523F、E523H及E523W。
  72. 如請求項70或請求項71之經修飾重組酶,其中該經修飾重組酶相對於屎腸球菌聚合酶(SEQ ID NO: 2)具有增加之類似物結合親和力。
  73. 如請求項54至72中任一項之經修飾重組酶,其包含一或多個對應於SEQ ID NO: 2之Q206、E436及L437的位置處之修飾。
  74. 如請求項73之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:Q206R、Q206K、Q206H、E436R、L437Y及L437E。
  75. 如請求項73或請求項74之經修飾重組酶,其中該經修飾重組酶相對於屎腸球菌聚合酶(SEQ ID NO: 2)具有改良之股置換作用。
  76. 如請求項54至75中任一項之經修飾重組酶,其包含一或多個對應於SEQ ID NO: 2之E436、L437、R534、T568及M569的位置處之修飾。
  77. 如請求項76之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:E436R、L437Y、L437E、R534K、T568D、T568S、M569T及M569V。
  78. 如請求項76或請求項77之經修飾重組酶,其中該經修飾重組酶相對於屎腸球菌聚合酶(SEQ ID NO: 2)具有增強之平均讀段長度。
  79. 如請求項54至78中任一項之經修飾重組酶,其包含對應於SEQ ID NO: 2之以下之一或多個位置處之修飾: T13、V25、C26、D27、N33、I34、F36、S42、D54、E60、M95、T110、T114、K119、P136、P147、E152、I153、P160、N175、F188、S216、R217、D232、A236、V247、P273、P275、E283、V315、S319、L320、Q323、E338、T345、F352、F353、T364、D414、D425、E436、F465、E485、A486、L490、S503、E523、V526、G547、L555、R558、V564、M569及T571。
  80. 如請求項79之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:T13N、V25L、C26W、D27E、N33T、I34V、F36V、S42T、D54Y、E60V、M95T、M95K、T110I、T114S、K119Q、P136T、P147Q、P147T、E152D、I153V、P160A、N175Y、F188C、S216G、S216R、R217G、D232H、A236G、V247D、P273R、P275S、E283K、V315L、S319R、L320M、L320T、Q323R、E338K、T345I、F352I、F353C、T364I、D414V、D425N、E436G、F465Y、E485D、A486E、L490M、S503T、E523V、V526L、G547S、L555R、R558H、V564L、M569K及T571S。
  81. 如請求項79或請求項80之經修飾重組酶,其中該經修飾重組酶相對於屎腸球菌聚合酶(SEQ ID NO: 2)具有增加之複製能力。
  82. 如請求項54至81中任一項之經修飾重組酶,其包含對應於SEQ ID NO: 2之以下之一或多個位置處之修飾: E139、E142、N145、I148、D167、D171、D189、D374、E385、E391、N467、E482、D492、K495、D521、E523、D533、E537及E545。
  83. 如請求項82之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:E139K、E139Q、E139R、E139H、E142K、E142H、E142R、E142Q、N145K、N145H、N145R、I148K、I148H、I148R、D167P、D167K、D167H、D167R、D171K、D171H、D171R、D189K、D189H、D189R、D374G、D374Q、D374H、E385Y、E385K、E385R、E385N、E385Q、E385L、E385A、E391Y、E391W、E391K、E391F、N467R、N467K、N467H、N467S、N467T、E482K、E482H、E482R、D492H、D492K、D492R、K495R、D521K、D521H、D521R、E523K、E523Y、E523H、E523R、E523F、E523W、D533A、D533Q、D533T、D533R、D533S、E537K、E537H、E537R、E545K、E545H及E545R。
  84. 如請求項82或請求項83之經修飾重組酶,其中該經修飾重組酶相對於屎腸球菌聚合酶(SEQ ID NO: 2)具有增加之正電性表面電荷。
  85. 如請求項54至84中任一項之經修飾重組酶,其包含對應於SEQ ID NO: 2之以下之一或多個位置處之修飾: K4、S22、D27、I34、D54、E60、E85、M95、N106、T110、Q122、Y133、P136、P147、D167、T211、D232、P275、R308、S319、L320、E323、D337、E338、D341、T345、F352、T364、D414、F465、T479、E485、L490、S493、Q513及R558。
  86. 如請求項85之經修飾重組酶,其中修飾為選自由以下組成之群的胺基酸取代:K4R、S22A、D27E、I34V、D54Y、E60V、E60L、E85P、M95K、T110I、N106G、Q122V、Y133L、P136T、P147Q、P147T、D167P、T211A、D232K、P275S、R308G、S319R、L320M、Q323V、D337G、E338K、D341T、T345I、F352I、T364I、D414V、F465Y、T479V、E485D、L490M、S493P、Q513D及R558H。
  87. 如請求項85或請求項86之經修飾重組酶,其中該經修飾重組酶相對於屎腸球菌聚合酶(SEQ ID NO: 2)具有增加之穩定性。
  88. 如請求項54至87中任一項之經修飾重組酶,其中該經修飾重組酶包含表7中所列之修飾之組合。
  89. 如請求項1至88中任一項之經修飾重組酶,其進一步包含純化標籤。
  90. 如請求項89之經修飾重組酶,其中該純化標籤為C端標籤。
  91. 如請求項89之經修飾重組酶,其中該純化標籤為N端標籤。
  92. 如請求項89至91中任一項之經修飾重組酶,其中該純化標籤為His標籤。
  93. 如請求項1至92中任一項之經修飾重組酶,其進一步包含偶合基團。
  94. 如請求項93之經修飾重組酶,其中該偶合基團附接在該重組聚合酶之C末端處。
  95. 如請求項93之經修飾重組酶,其中該偶合基團附接在該重組聚合酶之N末端處。
  96. 如請求項93至95中任一項之經修飾重組酶,其中該偶合基團係生物素標記序列。
  97. 如請求項93至95中任一項之經修飾重組酶,其中該偶合基團係雙生物素標記序列。
  98. 如請求項1至88中任一項之經修飾重組酶,其包含His標籤及生物素標記或雙生物素標記序列。
  99. 如請求項1至98中任一項之經修飾重組酶,其固定於表面上。
  100. 如請求項99之經修飾重組酶,其中該表面包含奈米孔口。
  101. 一種經分離核酸分子,其編碼如請求項1至98中任一項之經修飾重組酶。
  102. 一種組合物,其包含如請求項1至98中任一項之經修飾重組酶。
  103. 一種定序核酸之方法,該方法包含使如請求項1至98中任一項之經修飾重組酶與定序反應混合物接觸。
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