TW202110792A - 殺真菌芳基脒 - Google Patents
殺真菌芳基脒 Download PDFInfo
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- TW202110792A TW202110792A TW109117393A TW109117393A TW202110792A TW 202110792 A TW202110792 A TW 202110792A TW 109117393 A TW109117393 A TW 109117393A TW 109117393 A TW109117393 A TW 109117393A TW 202110792 A TW202110792 A TW 202110792A
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- ITDRVJXDQOONPC-UHFFFAOYSA-N urea;hydrofluoride Chemical compound F.NC(N)=O ITDRVJXDQOONPC-UHFFFAOYSA-N 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 239000004562 water dispersible granule Substances 0.000 description 1
- 238000009333 weeding Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000005943 zeta-Cypermethrin Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- GTLDTDOJJJZVBW-UHFFFAOYSA-N zinc cyanide Chemical compound [Zn+2].N#[C-].N#[C-] GTLDTDOJJJZVBW-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
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- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
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- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/12—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to hydrogen atoms
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Abstract
本揭露關於具有式I之芳基脒及其作為殺真菌劑之用途。
Description
本發明係有關於殺真菌芳基脒。
殺真菌劑係天然或合成來源之化合物,可起到保護和/或治療植物免受農業相關真菌造成的損害之作用。通常,沒有一種殺真菌劑在所有情況下皆為有用的。因此,正在進行研究以產生可能具有更好性能,更易於使用且成本更低之殺真菌劑。
本揭露關於芳基脒及其作為殺真菌劑之用途。本揭露之化合物可以提供針對子囊菌綱、擔子菌綱、半知菌綱和卵菌綱的保護。
本揭露之一個實施方式可以包括具有式I之化合物:
I
其中
R1
選自由以下組成之群組:氫、C1
-C8
烷基、C1
-C8
經取代的烷基、C2
-C8
烯基、C2
-C8
經取代的烯基、C2-
C8
炔基、C2
-C8
經取代的炔基、C3
-C8
環烷基、C3
-C8
經取代的環烷基、C3
-C8
雜環烷基、C3
-C8
經取代的雜環烷基、C5
-C7
雜芳基、C5
-C7
經取代的雜芳基、苯基、經取代的苯基、苄基、和經取代的苄基;
每個R2
、R3
、R4
、和R5
獨立地選自由以下組成之群組:氫、鹵素、氰基、硝基、C1
-C8
烷基、C1
-C8
經取代的烷基、C2
-C8
烯基、C2
-C8
經取代的烯基、C2
-C8
炔基、C2
-C8
經取代的炔基、C1
-C8
烷氧基、和C1
-C8
經取代的烷氧基;
R6
選自由以下組成之群組:氫、C1
-C8
烷基、C1
-C8
經取代的烷基、C2-
C8
烯基、C2-
-C8
經取代的烯基、C2-
C8
炔基、C1
-C8
經取代的炔基、C1
-C8
烷氧基、C1
-C8
經取代的烷氧基、硫醇、烷硫基、和經取代的烷硫基;
或R6
和R7
可以共價鍵合在一起以形成飽和的或不飽和的C3
-C8
雜環烷基或C3
-C8
經取代的雜環烷基基團;
每個R7
和R8
獨立地選自由以下組成之群組:氫、C1
-C8
烷基、C1
-C8
經取代的烷基、C2-
C8
烯基、C2
-C8
經取代的烯基、C2-
C8
炔基、C2
-C8
經取代的炔基、C3
-C8
環烷基、C3
-C8
經取代的環烷基、苯基、經取代的苯基、苄基、和經取代的苄基;
或R7
和R8
可以共價鍵合在一起以形成飽和的或不飽和的C3
-C8
雜環烷基或C3
-C8
經取代的雜環烷基基團;
其中任何和所有雜環可含有至多三個選自由O、N和S組成之群組的雜原子;
或其互變異構物或鹽。
本揭露之另一個實施方式可以包括用於控制或預防真菌侵襲的殺真菌組成物,其包含上述化合物和植物學上可接受的載體物質。
本揭露之又一個實施方式可以包括用於控制或預防植物上真菌侵襲之方法,該方法包括將殺真菌有效量的一種或多種上述化合物施用於真菌、種子、植物以及與植物相鄰的區域中至少一者的步驟。
熟悉該項技術者將理解,以下術語可在其定義內包括通用的「R」-基團,例如「術語烷氧基係指-OR取代基」。還應理解,在以下術語的定義內,包括該等「R」基團係出於說明目的,並且不應解釋為關於式I之限制或受取代基的限制。
術語「烷基」係指由碳和氫原子組成的支鏈、直鏈或飽和的非環取代基,包括但不限於甲基、乙基、丙基、丁基、異丙基、異丁基、三級丁基、戊基、己基等。
術語「烯基」係指由碳和氫組成的無環、不飽和(至少一個碳-碳雙鍵)、支鏈或直鏈的取代基,包括但不限於乙烯基、丙烯基、丁烯基、異丙烯基、異丁烯基等。
術語「炔基」係指由碳和氫組成的無環、不飽和(至少一個碳-碳三鍵)、支鏈或直鏈的取代基,例如乙炔基、炔丙基、丁炔基、和戊炔基。
術語「環烯基」係指由碳和氫組成的單環或多環不飽和(至少一個碳-碳雙鍵)取代基,例如環丁烯基、環戊烯基、環己烯基、降莰烯基、二環[2.2.2]辛烯基、四氫萘基、六氫萘基、和八氫萘基。
術語「環烷基」係指由碳和氫組成的單環或多環飽和取代基,例如環丙基、環丁基、環戊基、降莰基、二環[2.2.2]辛基、和十氫萘基。
術語「環烷氧基」係指進一步由碳-氧單鍵組成的環烷基,例如環丙基氧基、環丁基氧基、環戊基氧基、降莰基氧基、和二環[2.2.2]辛基氧基。
術語「芳基」和「Ar」係指任何含有0個雜原子的單環或雙環的芳香族環,例如苯基和萘基。
術語「雜芳基」係指任何含有1個或多個雜原子的單環或雙環的芳香族環,例如吡啶基、哌𠯤基和噻吩基。
術語「雜環烷基」係指含有碳和氫原子以及一個或多個雜原子的任何非芳香族單環或雙環。
術語「烷氧基」係指-OR取代基。
術語「氰基」係指-C≡N取代基。
術語「胺基」係指-N(R)2
取代基。
術語「鹵素」或「鹵代」係指一個或多個鹵素原子,定義為F、Cl、Br、和I。
術語「硝基」係指-NO2
取代基。
術語「硫醇」係指-SH取代基。
術語「烷硫基」係指-SR取代基。
術語「苄基」係指-CH2
-苯基取代基。
在整個揭露中,提及的具有式I之化合物還應理解為包括所有立體異構物,例如非鏡像異構物、鏡像異構物及其混合物。在另一個實施方式中,式 (I) 應理解為也包括其鹽或水合物。示例性的鹽包括但不限於:鹽酸鹽、氫溴酸鹽、氫碘酸鹽、三氟乙酸鹽和三氟甲烷磺酸鹽。
熟悉該項技術者還應理解,除非另外指出,否則允許另外的取代,只要滿足化學鍵合和應變能的規則並且產物仍顯示出殺真菌活性即可。
本揭露之另一個實施方式係具有式I之化合物用於保護植物免受植物致病性生物的侵襲或治療植物致病性生物侵染的植物之用途,包括施用具有式I之化合物或包含該化合物的組成物至土壤、植物、植物的一部分、葉子和/或根。
另外,本揭露之另一個實施方式係一種組成物,其用於保護植物免受植物致病性生物的攻擊和/或治療由植物致病性生物侵染的植物,該組成物包含具有式I之化合物和植物學上可接受的載體物質。
本揭露之化合物可以藉由多種已知技術中的任一種,作為化合物或作為包含該化合物的配製物來施用。例如,可以在不損害植物的商業價值的情況下將化合物施用於植物的根或葉以控制各種真菌。可以以任何通常使用的配製物類型的形式來施用物質,例如作為溶液、塵劑、可濕性粉劑、可流動的濃縮物或可乳化濃縮物。
較佳的是,本揭露之化合物以配製物的形式施用,該配製物包含一種或多種具有式I之化合物與植物學上可接受的載體。濃縮的配製物可以分散在水或其他液體中以用於施用,或者配製物可以是塵狀或顆粒狀,然後可以不經進一步處理就施用。可以根據農業化學領域中常規的程序來製備配製物。
本揭露設想了可以藉由其來配製一種或多種化合物用於遞送並用作殺真菌劑的所有媒介物。通常,配製物以水性懸浮液或乳液形式施用。這樣的懸浮液或乳液可以由水可溶性、水可懸浮性或可乳化性配製物製成,該配製物係固體(通常被稱為可濕性粉劑);或液體(通常稱為可乳化濃縮物、水性懸浮液或懸浮液濃縮物)。如將容易理解的,可以使用可以添加該等化合物的任何物質,只要其產生期望的效用而不會顯著干擾該等化合物作為抗真菌劑的活性即可。
可壓實形成水可分散顆粒劑的可濕性粉劑包含一種或多種具有式I之化合物、惰性載體和表面活性劑的緊密混合物。基於可濕性粉劑的總重量,化合物在可濕性粉劑中的濃度可以為約10重量%至約90重量%,更較佳的是約25重量%至約75重量%。在製備可濕性粉劑配製物時,可將化合物與任何精細分散的固體(例如,葉蠟石、滑石、白堊、石膏、漂白土、膨潤土、綠坡縷石、澱粉、酪蛋白、麵筋、蒙脫土、矽藻土、純淨的矽酸鹽等)複合。在這樣的操作中,通常將精細分散的載體和表面活性劑與一種或多種化合物共混並研磨。
基於濃縮物的總重量,具有式I之化合物的可乳化濃縮物可在合適的液體中包含便利的濃度,例如化合物的約1重量%至約50重量%。可以將化合物溶解在惰性載體中,該載體係與水可混溶性溶劑或與水不可混溶性有機溶劑和乳化劑的混合物。濃縮物可以用水和油稀釋以形成水包油乳液形式的噴霧混合物。可用的有機溶劑包括芳香族化合物(尤其是石油的高沸點萘和烯部分,諸如重芳香族石腦油)。也可使用其他有機溶劑,諸如包括松香衍生物的萜烯溶劑、諸如環己酮的脂族酮、和諸如2-乙氧基乙醇的複雜醇。
熟悉該項技術者可以容易地確定可以在本文中有利地使用的乳化劑,並且包括各種非離子、陰離子、陽離子和兩性乳化劑,或兩種或更多種乳化劑的共混物。可用於製備可乳化濃縮物的非離子型乳化劑的實例包括聚伸烷基二醇醚以及烷基和芳基酚、脂肪族醇、脂肪族胺或脂肪酸與環氧乙烷、環氧丙烷(如乙氧基化烷基酚)和被多元醇或聚氧化烯溶解的羧酸酯的縮合產物。陽離子乳化劑包括季銨化合物和脂肪胺鹽。陰離子乳化劑包括烷基芳基磺酸的油可溶性鹽(例如鈣)、硫酸化的聚乙二醇醚的油可溶性鹽以及磷酸化的聚乙二醇醚的合適的鹽。
可用於製備本揭露之化合物的可乳化濃縮物的代表性有機液體係芳香族液體,例如二甲苯、丙基苯級分;或混合的萘級分,礦物油,經取代的芳香族有機液體,例如鄰苯二甲酸二辛酯;煤油;各種脂肪酸的二烷基醯胺,特別是脂肪二醇的二甲基醯胺和二醇衍生物,例如二甘醇的正丁基醚、乙基醚或甲基醚,三甘醇的甲基醚,石油級分或碳氫化合物,例如礦物油,芳香族溶劑,石蠟油等;植物油例如大豆油、油菜籽油、橄欖油、蓖麻油、葵花籽油、椰子油、玉米油、棉花子油、亞麻子油、棕櫚油、花生油、紅花油、芝麻油、桐油等;上述植物油的酯;等等。兩種或更多種有機液體的混合物也可以應用於可乳化濃縮物的製備中。有機液體包括二甲苯、和丙基苯級分,在某些情況下最較佳的是二甲苯。表面活性分散劑通常用於液體配製物中,其量為分散劑與一種或多種化合物的總重量的0.1至20重量%。該配製物還可以含有其他相容性添加劑,例如植物生長調節劑和農業中使用的其他生物活性化合物。
水性懸浮液包括一種或多種具有式I之水不溶性化合物的懸浮液,基於水性懸浮液的總重量,以約1至約50重量%的濃度分散在水性媒介物中。懸浮液的製備方法係將一種或多種化合物精細研磨,然後將磨碎的物質劇烈混合到含有水和選自上述相同類型表面活性劑的媒介物中。還可以添加例如無機鹽和合成膠或天然膠的其他組分以增加水性媒介物的密度和黏度。
具有式I之化合物也可以顆粒配製物的形式應用,該顆粒配製物特別可用於應用於土壤。基於顆粒配製物的總重量,顆粒配製物通常含有約0.5至約10重量%的一種或多種化合物,其分散在惰性載體中,該惰性載體完全或大部分由粗分散的惰性物質如綠坡縷石、膨潤土、矽藻土、黏土或類似的廉價物質組成。通常藉由將化合物溶解於合適的溶劑中並且將其應用到已預先形成在約0.5 mm至約3 mm的適當粒度的顆粒載體中來製備此類配製物。合適的溶劑係化合物基本上或完全可溶於其中的溶劑。也可以藉由製造載體和化合物和溶劑的黏團或糊狀物並且擠壓並且乾燥以獲得所希望的顆粒粒度來製備此類配製物。
藉由將呈粉末形式的一種或多種化合物與合適的粉塵狀農業載體(諸如高嶺土、研磨的火山岩等)緊密混合來製備含有具有式I之化合物的塵劑。基於塵劑的總重量,塵劑可以適當地含有約1至約10重量百分比的化合物。
該配製物可以另外含有佐劑表面活性劑,以增強化合物在目標作物和生物上的沈積、潤濕和滲透。該等助劑表面活性劑可以視需要作為配製物的組分或作為桶混物使用。基於水的噴霧量,助劑表面活性劑的量通常為0.01至1.0體積%,較佳的是0.05至0.5體積%。合適的助劑表面活性劑包括但不限於乙氧基化壬基酚、乙氧基化的合成或天然醇、酯或磺基琥珀酸的鹽、乙氧基化有機矽、乙氧基化脂肪胺、表面活性劑與礦物或植物油的共混物、作物濃縮油(礦物油(85%)+ 乳化劑(15%));壬基酚乙氧基化物;苄基可可烷基二甲基季銨鹽;石油烴、烷基酯、有機酸、和陰離子表面活性劑的共混物;C9
-C11
烷基聚糖苷;磷酸化醇乙氧基化物;天然一級醇(C12
-C16
)乙氧基化物;二二級丁基酚EO-PO嵌段共聚物;甲基封端的聚矽氧烷;壬基酚乙氧基化物+尿素硝酸銨;乳化的甲基化種子油;十三烷基醇(合成)乙氧基化物(8EO);牛脂胺乙氧基化物(15 EO);PEG(400)二油酸酯-99。該配製物還可以包括水包油乳液,例如在美國專利申請序號11/495,228中揭露的那些,其揭露內容藉由引用明確地併入本文。
該配製物可視需要包括含有其他殺有害生物化合物的組合。此類另外的殺有害生物化合物可以是在選擇用於施用的介質中與本揭露之化合物相容並且不拮抗本發明的活性的殺真菌劑、殺昆蟲劑、除草劑、殺線蟲劑、殺蟎劑、殺節肢動物劑、殺細菌劑或其組合。因此,在這樣的實施方式中,另一種殺有害生物化合物被用作相同或不同殺有害生物用途的補充毒劑。組合中的具有式I之化合物和殺有害生物化合物通常可以以1 : 100至100 : 1的重量比率存在。
本揭露之化合物也可以與其他殺真菌劑組合以形成殺真菌混合物和其協同混合物。本揭露之殺真菌化合物通常可以與一種或多種其他殺真菌劑結合施用,以控制更廣泛範圍的不期望的疾病。當與其他一種或多種殺真菌劑結合使用時,本發明所要求保護的化合物可以與其他一種或多種殺真菌劑一起配製,與其他一種或多種殺真菌劑桶混或與其他一種或多種殺真菌劑順序施用。此類其他殺真菌劑可以包括2-(硫氰醯甲硫基)-苯并噻唑、2-苯基苯酚、8-羥基喹啉硫酸鹽、唑嘧菌胺、aminopyrifen、安美速、抗黴素、白粉寄生孢(Ampelomyces quisqualis
)、阿紮康唑、枯草芽孢桿菌(Bacillus subtilis
)、枯草芽孢桿菌菌株QST713、苯霜靈、苯菌靈、苯噻菌胺、苯并烯氟菌唑、苄基苯胺-磺酸鹽(BABS)、碳酸氫鹽、聯苯、噻枯唑、聯苯三唑醇、聯苯吡菌胺、滅瘟素、硼砂、波爾多混合劑、啶醯菌胺、溴菌唑、乙嘧酚磺酸酯、多硫化鈣、敵菌丹、克菌丹、多菌靈、萎鏽靈、環丙醯菌胺、香芹酮、氯芬同(chlazafenone)、地茂散、百菌清、乙菌利、盾殼黴(Coniothyrium minitans
)、氫氧化銅、辛酸銅、氯氧化銅、硫酸銅、硫酸銅(三元)、氧化亞銅、氰霜唑、環氟菌胺、霜脲氰、環唑醇、嘧菌環胺、棉隆、咪菌威、聯胺乙烯雙-(二硫代胺基甲酸酯)、抑菌靈、二氯芬、雙氯氰菌胺、噠菌酮、氯硝胺、乙黴威、苯醚甲環唑、野燕枯(difenzoquat ion)、二氟林、烯醯𠰌啉、醚菌胺、烯唑醇、烯唑醇-M、消蟎通、敵蟎普、二苯胺、二噻農、嗎菌靈醋酸鹽、嗎菌靈醋酸鹽、多果定、多果定游離鹼、克瘟散、enestrobin、烯肟菌酯、氟環唑、噻唑菌胺、乙氧喹、土菌靈、㗁唑菌酮、咪唑菌酮、氯苯嘧啶醇、腈苯唑、甲呋醯胺、環醯菌胺、氰菌胺、拌種咯、苯鏽啶、丁苯𠰌啉、胺苯吡菌酮、三苯錫、薯瘟錫、毒菌錫、福美鐵、嘧菌腙、氟啶胺、咯菌腈、氟茚唑菌胺、氟𠰌啉、氟吡菌胺、氟吡菌醯胺、唑呋草、fluoxapiprolin、氟嘧菌酯、氟喹唑、氟矽唑、磺菌胺、flutianil、氟醯胺、粉唑醇、氟唑菌醯胺、滅菌丹、甲醛、乙膦酸、三乙膦酸鋁、麥穗寧、呋霜靈、呋吡菌胺、雙胍鹽、雙胍鹽醋酸鹽、GY-81、六氯苯、己唑醇、惡黴靈、抑黴唑、抑黴唑硫酸鹽、亞胺唑、雙胍辛胺、雙胍辛胺三乙酸鹽、雙胍三辛烷苯基磺酸鹽、inpyrfluxam、iodocarb、種菌唑、ipfenpyrazolone、異稻瘟淨、異菌脲、丙森鋅、isofetamide、isoflucypram、稻瘟靈、吡唑萘菌胺、異噻菌胺、春日黴素、春日黴素鹽酸鹽水合物、kresoxium-methyl、海帶多糖、代森錳銅、代森錳鋅、雙炔醯菌胺、代森錳、精甲霜靈、嘧菌胺、滅鏽胺、敵蟎普、氯化汞、氧化汞、甘汞、甲霜靈、精甲霜靈、威百畝、安百畝、metam-potassium、威百畝、葉菌唑、磺菌威、甲基碘、敵線酯、代森聯、苯氧菌胺、苯菌酮、米多黴素、腈菌唑、代森鈉、酞菌酯、氟苯嘧啶醇、辛噻酮、甲呋醯胺、油酸(脂肪酸)、肟醚菌胺、惡霜靈、氟噻唑吡乙酮、喹啉銅、咪唑富馬酸鹽、氧化萎鏽靈、稻瘟酯、戊菌唑、戊菌隆、氟唑菌苯胺、五氯苯酚、月桂酸五氯苯酯、吡噻菌胺、醋酸苯汞、膦酸、四氯苯酞、啶氧菌酯、多氧菌素B、多抗黴素、保粒黴素、碳酸氫鉀、羥基喹啉硫酸氫鉀鹽、噻菌靈、咪鮮胺、腐黴利、霜黴威、霜黴威鹽酸鹽、丙環唑、甲基代森鋅、丙氧喹啉、丙硫菌唑、氟唑菌醯羥胺、唑胺菌酯、唑菌酯、唑菌胺酯、pyraziflumid、定菌磷、吡菌苯威、稗草畏、啶斑肟、嘧黴胺、甲氧苯啶、咯喹酮、滅藻醌、喹氧靈、五氯硝基苯、大虎杖(Reynoutria sachalinensis
)提取物、氟唑環菌胺、硫矽菌胺、矽氟唑、2-苯基苯酚鈉、碳酸氫鈉、五氯酚酸鈉、螺環菌胺、硫磺、SYP-Z048、煤焦油、戊唑醇、特弗喹啉(tebufloquin)、四氧硝基苯、氟醚唑、噻苯咪唑、噻呋醯胺、甲基硫菌靈、福美雙、噻醯菌胺、甲基立枯磷、對甲抑菌靈、三唑酮、唑菌醇、咪唑𠯤、三環唑、克啉菌、肟菌酯、氟菌唑、𠯤胺靈、滅菌唑、有效黴素、精高效氯氟氰菊酯、霜黴滅、農利靈、代森鋅、福美鋅、苯醯菌胺、嗜油假絲酵母(Candida oleophila
)、尖孢鐮刀菌(Fusarium oxysporum
)、黏帚黴屬(Gliocladium
)物種、大伏革菌(Phlebiopsis gigantea
)、灰綠鏈黴菌(Streptomyces griseoviridis
)、木黴屬(Trichoderma
)物種、(RS
)-N
-(3,5-二氯苯基)-2-(甲氧基甲基)-琥珀醯亞胺、1,2-二氯丙烷、1,3-二氯-1,1,3,3-四氟丙酮水合物、1-氯-2,4-二硝基萘、1-氯-2-硝基丙烷、2-(2-十七烷基-2-咪唑啉-1-基)乙醇、2,3-二氫-5-苯基-1,4-二噻1,1,4,4-四氧化物、2-醋酸甲氧基乙基汞、2-甲氧乙氯汞、2-滅菌矽、3-(4-氯苯基)-5-甲基羅丹寧、4-(2-硝基丙-1-烯基)苯基硫氰酸酯、
胺基丙基磷酸、防黴靈、氧化福美雙、多硫化鋇、Bayer 32394、麥鏽靈、敵菌腙、bentaluron、benzamacril; benzamacril-isobutyl、抑菌啉(benzamorf)、樂殺蟎、雙(甲基汞)硫酸鹽、雙(三丁基錫)氧化物、丁硫啶、鎘鈣銅鋅的硫酸鉻酸鹽、嗎菌威、CECA、滅瘟唑、雙胺靈、chlorfenazole、四氯喹惡啉、氯咪巴唑、雙(3-苯基水楊酸)銅、鉻酸銅鋅、丁香菌酯、硫雜靈、硫酸肼銅、福美銅氯、環菌胺、青菌靈(cypendazole)、酯菌胺、癸磷錫、dichlobentiazox、二氯萘醌、菌核利、苄氯三唑醇、二甲嘧酚、鄰敵蟎消、硝辛酯、硝丁酯、dipymetitrone、雙硫氧吡啶、滅菌磷、多地辛、敵菌酮、EBP、烯肟菌酯(enoxastrobin)、ESBP、乙環唑、代森硫、乙嘧酚(ethirim)、烯肟菌胺、敵磺鈉、咪菌腈、種衣酯、fenpicoxamid、florylpicoxamid、氟菌蟎酯、氟醚菌醯胺、三氟苯唑、二甲呋醯胺、呋菌唑、呋醚唑、拌種胺、呋菌隆、果綠啶、灰黃黴素、丙烯酸喹啉酯、Hercules 3944、環己硫磷、ICIA0858、ipfentrifluconazole、ipflufenoquin、異潘松(isopamphos)、異瓦二酮(isovaledione)、mandestrobin、鄰醯胺、甲威苯咪、氯氟醚菌唑、肼菌酮(metazoxolon)、呋菌胺、氰胍甲汞、噻菌胺、metyltetraprole、代森環、糠氯酸酐、甲菌利、N
-3,5-二氯苯基-琥珀醯亞胺、N
-3-硝基苯基衣康醯亞胺、納他黴素、N
-乙基汞-4-甲苯磺醯苯胺、雙(二甲基二硫胺基甲酸酯)鎳、OCH、苯基汞二甲基二硫代胺基甲酸酯、苯硝酸汞、氯瘟磷、硫菌威;撲菌硫、比鏽靈、pyrapropoyne、pyridachlometyl、定菌腈、啶菌㗁唑、吡氯靈、氯吡呋醚、羥基喹啉基乙酮;喹烯酮硫酸鹽、醌菌腙、quinconazole、quinofumelin、吡咪唑、N-水楊醯苯胺、SSF-109、戊苯碸、福美雙聯(tecoram)、噻二呋(thiadifluor)、噻菌腈、硫氯苯亞胺、托布津、克殺蟎、硫氰苯甲醯胺(tioxymid)、三唑磷胺、嘧菌醇、丁基三唑、水楊菌胺、氯啶菌酯、三氟苯嘧啶、福美甲胂、氰菌胺、及其任何組合。
另外,本文所述之化合物可以在選擇用於施用的介質中與與本揭露之化合物相容以形成殺有害生物混合物及其協同混合物的其他殺有害生物劑(包括殺昆蟲劑、殺線蟲劑、殺蟎劑、殺節肢動物劑、殺細菌劑或其組合)組合。本揭露之殺真菌化合物可以與一種或多種其他殺有害生物劑結合施用,以控制更廣泛範圍的不期望的有害生物。當與其他殺有害生物劑結合使用時,本發明要求保護的化合物可以與其他一種或多種殺有害生物劑一起配製、與其他一種或多種殺有害生物劑桶混或與其他一種或多種殺有害生物劑順序施用。典型的殺昆蟲劑包括但不限於:1,2-二氯丙烷、阿維菌素、高滅磷、啶蟲脒、家蠅磷、乙醯蟲腈、氟丙菊酯、丙烯腈、acynonapyr、雙丙環蟲酯、棉鈴威、涕滅威、涕滅氧威、阿耳德林、亞列寧、阿洛胺菌素、除害威、α-氯氰菊酯、蛻皮激素,α-硫丹、賽硫磷、滅害威、胺吸磷、胺吸磷草酸鹽、雙甲脒、假木賊鹼、乙基殺撲磷、印楝素、甲基吡㗁磷、乙基穀硫磷、甲基穀硫磷、偶氮磷、六氟矽酸鋇、椒菊酯、㗁蟲威、丙硫克百威、殺蟲磺、benzpyrimoxan、高效氟氯氰菊酯、高效氯氰菊酯、聯苯菊酯、生物烯丙菊酯、生物乙酸次甲酯、生物氯菊酯、雙三氟蟲脲、硼砂、硼酸、broflanilide、溴苯烯磷、溴環烯、溴-DDT、溴硫磷、乙基溴硫磷、丁苯胺酯、噻𠯤酮、畜蟲威、脫甲基丁嘧啶磷、丁酮威、布托酯、丁酮氧威、硫線磷、砷酸鈣、多硫化鈣、毒殺芬、氯滅殺威、甲萘威、呋喃丹、二硫化碳、四氯化碳、三硫磷、丁硫克百威、殺螟丹、殺螟丹鹽酸鹽、氯蟲苯甲醯胺、冰片丹、氯丹、開蓬、殺蟲脒、鹽酸殺蟲脒、氯氧磷、溴蟲腈、氯芬磷、定蟲隆、氯甲磷、氯仿、氯化苦、右旋反式氯丙菊酯、氯辛硫磷、氯吡唑磷、毒死蜱、甲基毒死蜱、蟲蟎磷、環蟲醯肼、瓜菊酯I、瓜菊酯II、瓜葉除蟲菊酯、毒死蜱、甲基毒死蜱、蟲蟎磷、環蟲醯肼、瓜菊酯I、瓜菊酯II、砷酸銅、環烷酸銅、油酸銅、庫馬磷、環毒硫磷、克羅米通、丁烯磷、克蘆磷酯、冰晶石、苯腈磷、殺螟腈、果蟲磷、溴氰蟲醯胺、環溴蟲醯胺、環菊酯、乙氰菊酯、百樹菊酯、氯氟氰蟲醯胺、三氯氟氰菊酯、氯氰菊酯、苯醚氰菊酯、環丙胺𠯤、賽滅磷、DDT、單甲基克百威、溴氰菊酯、田樂磷、氧田樂磷、硫田樂磷、內吸磷、甲基內吸磷、內吸氧磷、甲基異內吸磷、內吸磷-S、滅賜松、碸吸磷、殺蟎隆、氯亞磷、矽藻土、二𠯤磷、異氯硫磷、除線磷、敵敵畏、二氯噻吡嘧啶、敵來死、百治磷、地昔尼爾、狄氏劑、伏蟲脲、雙羥丙茶鹼、四氟甲醚菊酯、二美氟、地麥威、樂果、苄菊酯、甲基毒蟲畏、敵蠅威、消蟎酚(dinex或dinex-diclexine)、丙硝酚、戊硝酚、噻蟲胺、苯蟲醚、蔬果磷、二氧威、敵殺磷、乙拌磷、噻喃磷、右旋薴烯、DNOC、DNOC-銨、DNOC-鉀、DNOC-鈉、朵拉克丁、脫皮甾酮、艾瑪菌素(emamectin或emamectin benzoate)、EMPC、烯炔菊酯、硫丹、內毒磷、異狄氏劑、EPN、保幼醚、依立諾克丁、ε-甲氧苄氟菊酯、ε-甲氧苄氟菊酯單體(momfluorothrin)、esdepalléthrine、高氰戊菊酯、依他磷、乙硫苯威、乙硫磷、乙蟲腈、益硫磷、滅線磷、甲酸乙酯、乙滴滴、二溴化乙烯、二氯化乙烯、環氧乙烷、醚菊酯、氧嘧啶磷、EXD、胺磺磷、苯線磷、伏蟎唑、芬氯磷、雙乙威、五氟苯菊酯、殺螟硫磷、仲丁威、氧嘧醯胺、苯氧威、吡氯氰菊酯、甲氰菊酯、葑硫松、倍硫磷、乙基倍硫磷、氰戊菊酯、氟蟲腈、flometoquin、氟啶蟲醯胺、fluazaindolizine、氟蟲雙醯胺、氟氯雙苯隆、氟蟎脲、氟氰菊酯、氟噻蟲碸、嘧蟲胺、氟蟲脲、三氟醚菊酯、丁烯氟蟲腈、氟己芬、氟吡呋喃酮、flupyrimin、氟胺氰菊酯、fluxametamide、地蟲硫磷、伐蟲脒、伐蟲脒鹽酸鹽、安果、胺甲威、胺甲威鹽酸鹽、丁苯硫磷、福司吡酯、伐線丹、呋線威、糠菊酯、γ-三氯氟氰菊酯、γ-HCH、溴氟醚菊酯、氯蟲醯肼、HCH、HEOD、七氯、heptafluthrin、庚烯磷、速殺硫磷、氟鈴脲、HHDN、氟蟻腙、氰化氫、烯蟲乙酯、喹啉威、吡蟲啉、庚烯磷、速殺硫磷、氟鈴脲、HHDN、氟蟻腙、氰化氫、烯蟲乙酯、喹啉威、異柳磷、甲基異柳磷、異丙威、稻瘟靈、異丙磷、異㗁唑磷、伊維菌素、茉莉菊酯I、茉莉菊酯II、碘硫磷、保幼激素I、保幼激素II、保幼激素III、κ-聯苯菊酯、κ-七氟菊酯、氯戊環、烯蟲炔酯、λ-氯氟氰菊酯、砷酸鉛、雷皮菌素、對溴磷、林丹、丙嘧硫磷、氯芬奴隆、噻唑磷、馬拉硫磷、丙蟎氰、疊氮磷、滅蚜磷、甲基滅蚜磷、滅蚜松、氯氟醚菊酯、二噻磷、氯化亞汞、倍硫磷亞碸、氰氟蟲腙、蟲蟎畏、甲胺磷、殺撲磷、滅蟲威、久效磷、滅多蟲、甲氧普烯、甲氧氯、甲氧蟲醯肼、甲基溴、異硫氰酸甲酯、甲基氯仿、二氯甲烷、甲氧苄氟菊酯、速滅威、唾蟲酮、速滅磷、自克威、米爾倍黴素、米爾倍黴素肟、丙胺氟磷、滅蟻靈、殺蟲單(monosultap)、甲氧苄氟菊酯單體、久效磷、殺蟲單(monomehypo)、殺蟲單(monosultap)、茂果、莫昔克丁、萘肽磷、二溴磷、萘、菸鹼、尼氟利地、烯蟲靈、硝蟲噻𠯤、腈叉威、雙苯氟脲、多氟脲、氧化樂果、草胺醯、碸吸磷、異亞碸磷、碸拌磷、對二氯苯、對硫磷、甲基對硫磷、氟幼脲、五氯酚、撲滅司林、芬硫磷、苯氧司林、稻豐散、甲拌磷、伏殺硫磷、環硫磷、亞胺硫磷、對氯硫磷、磷胺、磷化氫、辛硫磷、甲基辛硫磷、甲胺嘧磷、抗蚜威、乙基嘧啶磷、甲基嘧啶磷、亞砷酸氫鉀、硫氰酸鉀、pp'-DDT、右旋丙炔菊酯、早熟烯I、早熟烯II、早熟烯III、乙醯嘧啶磷、丙溴磷、環丙氟靈、丙氟菊酯、蜱虱威、猛殺威、丙蟲磷、胺丙畏、殘殺威、乙噻唑磷、丙硫磷、發果、丙苯烴菊酯、吡唑硫磷、吡𠯤氟蟲腈、定菌磷、呋喃菊酯、除蟲菊酯I、除蟲菊酯II、除蟲菊酯、噠蟎酮、啶蟲丙醚、嗒𠯤硫磷、pyrifluquinazon、嘧蟎醚、嘧蟎胺、嘧啶磷、吡啶氟蟲腈、蚊蠅醚、苦木科植物苦味液(quassia)、喹硫磷、甲基喹硫磷、畜甯磷、雷複尼特、苄呋菊酯、魚藤酮、魚尼丁、藜蘆鹼、八甲磷、司拉克丁、矽烴菊酯、矽膠、亞砷酸鈉、氟化鈉、六氟矽酸鈉、硫氰酸鈉、蘇果、乙基多殺菌素、多殺菌素、螺甲蟎酯、spiropidion、螺蟲乙酯、磺苯醚隆、sulcofuron-sodium、氟蟲胺、治螟磷、氟啶蟲胺腈、氟化硫醯、硫丙磷、氟胺氰菊酯、噻蟎威、TDE、蟲醯肼、吡蟎胺、嘧丙磷、伏蟲脲、七氟菊酯、替美磷、TEPP、環戊烯丙菊酯、三級丁磷、四氯蟲醯胺、四氯乙烷、殺蟲畏、四甲菊酯、四氟醚菊酯、氟氰蟲醯胺、θ-氯氰菊酯、噻蟲啉、噻蟲𠯤、塞克磷、抗蟲威、殺蟲環、草酸殺蟲環、硫雙威、久效威、二甲硫吸磷、殺蟲雙、殺蟲雙鈉(thiosultap-disodium)、殺蟲單鈉(thiosultap-monosodium)、蘇雲金素、tioxazafen、唑蟲醯胺、四溴菊酯、四氟菊酯、反式苄氯菊酯、苯蟎噻、唑蚜威、三唑磷、敵百蟲、異皮蠅磷-3、壤蟲磷、三氯丙氧磷、三氟苯嘧啶、殺蟲脲、混殺威、甲硫保幼素、tyclopyrazoflor、滅蚜硫磷、氟吡唑蟲、XMC、滅殺威、ζ-氯氰菊酯、丙硫㗁唑磷(zolaprofos)、及其任何組合。
另外,本文所述之化合物可以與除草劑組合以形成殺有害生物混合物及其協同混合物,該除草劑在選擇用於施用的介質中與本揭露之化合物相容並且不拮抗本發明的化合物的活性。本揭露之殺真菌化合物可以與一種或多種除草劑結合施用,以控制更廣泛範圍的不期望的植物。當與除草劑結合使用時,本發明要求保護的化合物可以與一種或多種除草劑一起配製、與一種或多種除草劑桶混或與一種或多種除草劑順序施用。典型的除草劑包括但不限於:4-CPA;4-CPB;4-CPP;2,4-D;3,4-DA;2,4-DB;3,4-DB;2,4-DEB;2,4-DEP;3,4-DP;2,3,6-TBA;2,4,5-T;2,4,5-TB;乙草胺、氟鎖草醚、苯草醚、丙烯醛、甲草胺、草毒死、禾草滅、烯丙醇、五氯戊酮酸、胺𠯤酮、莠滅淨、特草𠯤酮、胺唑草酮、醯嘧磺隆、環丙嘧啶酸、氯胺吡啶酸、胺草磷、殺草強、胺基磺酸銨、莎稗磷、疏草隆、黃草靈、莠去通、阿特拉津、唑啶草酮、四唑嘧磺隆、疊氮津、燕麥靈、BCPC、氟丁醯草胺、氟丁醯草胺-M、草除靈、苯卡巴腙、氟草胺除草劑、呋草黃、苄嘧磺隆、地散磷、滅草松、胺酸殺、雙苯嘧草酮、苄草胺、苯并雙環酮、吡草酮、氟磺胺草、新燕靈、噻草隆、氟吡草酮、甲酯除草醚、雙丙胺膦、雙草醚、bixlozone、硼砂、除草定、糠草腈、溴丁醯草胺、殺草全、溴苯腈、溴殺草敏、丁草胺、布他那西、抑草磷、丁烯草胺、丁硫咪唑酮、丁噻隆、二級丁靈、丁苯草酮、播土隆、丁草特、二甲砷酸、唑草胺、氯酸鈣、氰胺化鈣、克草胺酯、威磺靈、長殺草、咔唑、草敗死、唑草酮、CDEA、CEPC、甲氧除草醚、草滅平、丁醯草胺、炔禾靈、可樂津、氯溴隆、氯炔靈、乙氧苯隆、伐草克、燕麥酯、氟啼殺、氯茀素、氯草敏、氯嘧磺隆、草枯醚、三氯丙酸、氯麥隆、枯草隆、羥敵草腈、氯苯胺靈、氯磺隆、敵草索、草克樂、吲哚酮草酯、環庚草醚、醚磺隆、咯草隆、氯醯草膦、烯草同、碘氯啶酯、炔草酸、草氯丙酸、可滅蹤、稗草胺、坐果安、氯丙氧定、畢克草、氯酯磺草胺、CMA、硫酸銅、CPMF、CPPC、醚草敏、甲酚、苄草隆、氰草淨、氰草津、環草敵、cyclopyranil、cyclopyrimorate、環磺隆、環殺草、環莠隆、氰氟草酯、牧草快、環草津、三環塞草胺、環丙草胺、殺草隆、茅草枯、棉隆、敵草樂、甜菜安、敵草淨、燕麥敵、百草敵、敵草腈、氯全隆、苄胺靈、滴丙酸、精滴丙酸、禾草靈、雙氯磺草胺、二乙除草雙、甘草鎖、戊味禾草靈、枯莠隆、野燕枯、吡氟草胺、二氟吡隆、㗁唑隆、哌草丹、二甲草胺、異戊乙淨、二甲噻草胺、精二甲噻草胺、草滅散、草噠酮、敵樂胺、迪樂芬諾、丙硝酚、戊硝酚、地樂酚、特樂酚、草乃敵、異丙淨、敵草快、賽松、氟硫草定、達有龍、DMPA、DNOC、DSMA、EBEP、甘草津、草多索、磺唑草、EPTC、抑草蓬、戊草丹、乙丁烯氟靈、胺苯磺隆、噻二唑隆、抑草威、乙呋草黃、氯氟草醚、乙氧嘧磺隆、硝草酚、乙胺草醚、乙氧苯草胺、EXD、醯苯磺威、涕丙酸、㗁唑禾草靈、精㗁唑禾草靈、fenoxasulfone、fenquinotrione、氯苯氧乙醇、噻唑禾草靈、四唑醯草胺、非草隆、硫酸亞鐵、氟燕靈、強氟燕靈、嘧啶磺隆、雙氟磺草胺、氯氟吡啶酯、吡氟禾草靈、精吡氟禾草靈、異丙吡草酯、氟酮磺隆、氟吡磺隆、氟消草、氟噻草胺、吡氟草胺、氟嗒𠯤草酯、唑嘧磺草胺、氟默𠯤、氟烯草酸、丙炔氟草胺、氟米丙平、伏草隆、消草醚、乙羧氟草醚、唑唆草、氟除草醚、氟硫隆、氟胺草唑、氟丙嘧草、四氟丙酸、氟啶嘧磺隆、氟啶草酮、氟咯草酮、氟草定、呋草酮、𠯤草酸、氟磺胺草醚、甲醯嘧磺隆、殺木膦、呋氧草醚、草丁膦、精草丁膦、草甘膦、氟氯吡啶酯、氟硝磺醯胺、氯吡嘧磺隆、氟啶草、吡氟氯禾靈、精吡氟氯禾靈、六氯丙酮、六氟鹽、六𠯤同、咪草酸、甲氧咪草煙、甲基咪草煙、依滅草、滅草喹、咪草煙、唑吡嘧磺隆、茚草酮、茚𠯤氟草胺、碘草腈、碘甲烷、碘甲磺隆、優芬磺隆、碘苯腈、抑草津、艾分卡巴腙、丙草定、丁咪胺、異草定、丁𠯤草酮、異草完隆、氮草草、異丙樂靈、異丙隆、異惡隆、異㗁醯草胺、異惡氯草酮、異㗁唑草酮、異惡草醚、卡草靈、克螺多、lancotrione、乳氟禾草靈、環草定、利穀隆、MAA、MAMA、MCPA、MCPA-硫乙基、MCPB、甲氯丙酸、精甲氯丙酸、甲基特樂酯、苯噻醯草胺、氟磺醯草胺、滅莠津、甲基二磺隆、甲基磺草酮、威百畝、㗁唑醯草胺、苯𠯤草酮、吡草胺、雙醚氯吡嘧磺隆、二甲達草伏、甲基苯噻隆、美索丙鉑林、滅草唑、甲硫苯威、甲硫唑啉、滅草恒、醚草通、格草淨、甲基溴、異硫氰酸甲酯、甲基殺草隆、哌喃隆、溴穀隆、異丙甲草胺、磺草唑胺、甲氧隆、賽克津、甲磺隆、草達滅、庚醯草胺、特㗁唑隆、一氯乙酸、綠穀隆、滅草隆、伐草快、MSMA、萘丙胺、敵草胺、敵草胺-M、萘草胺、草不隆、煙嘧磺隆、氟氯草胺、磺樂靈、除草醚、三氟甲草醚、達草滅、草完隆、OCH、坪草丹、鄰二氯苯、嘧苯胺磺隆、胺磺樂靈、丙炔㗁草酮、㗁草酮、草噠松、環氧嘧磺隆、㗁𠯤草酮、乙氧氟草醚、對氟隆、百草枯、克草猛、天竺葵酸、二甲戊樂靈、平速爛、五氯苯酚、戊醯苯草胺、環戊㗁草酮、氟草磺胺、烯草胺、棉胺甯、甜菜甯、甜菜寧-乙基、稀草隆、醋酸苯汞、毒莠定、氟吡草胺、唑啉草酯、哌草磷、亞砷酸鉀、疊氮化鉀、氰酸鉀、丙草胺、氟嘧磺隆、環丙腈津、胺基丙氟靈、氟唑草胺、環丙氟靈、環苯草酮、甘撲津、撲滅通、撲草淨、撲草胺、敵稗、喔草酯、撲滅津、苯胺靈、異丙草胺、丙苯磺隆、丙嘧磺隆、戊炔草胺、甲硫磺樂靈、苄草丹、氟磺隆、撲滅生、廣草胺、比達農、雙唑草腈、吡草醚、磺醯草吡唑、吡唑特、吡嘧磺隆、苄草唑、嘧啶肟草醚、稗草丹、氯草定、吡啶達醇、噠草特、環酯草醚、嘧草醚、嘧啶硫蕃、嘧硫草醚、嘧氧碸、甲氧磺草胺、二氯喹啉酸、喹草酸、滅藻醌、氯藻胺、喹禾靈、精喹禾靈、硫氰苯乙胺、碸嘧磺隆、苯嘧磺草胺、S-異丙甲草胺、另丁津、密草通、西殺草、環草隆、西瑪津、西瑪通、西草淨、SMA、亞砷酸鈉、疊氮化鈉、氯酸鈉、磺草酮、草克死、甲磺草胺、甲嘧磺隆、磺醯磺隆、硫酸、吖庚磺酯、滅草靈、TCA、牧草胺、得匍隆、特呋喃隆、環磺酮、哌喃草酮、特草定、特草靈、猛殺草、甲氧去草淨、特丁津、去草淨、四氟隆、甲氧噻草胺、噻氟隆、噻草定、噻二唑胺、噻苯隆、噻酮磺隆-甲基、噻吩磺隆、禾草丹、tiafenacil、仲草丹、替可裡姆、托吡拉特、苯吡唑草酮、肟草酮、氟酮磺草胺、野麥畏、醚苯磺隆、三𠯤氟草胺、苯磺隆、殺草畏、綠草定、滅草環、草達津、三氟啶磺隆、三氟地殺𠯤、氟樂靈、氟胺磺隆、翠福、三氟禾草肟、三羥基三𠯤、三甲隆、弗草酮、草達克、三氟甲磺隆、滅草猛和二甲苯草胺。
在本發明的另一個實施方式中,式1可以與一種或多種活性成分(例如上文所述之那些)組合使用(諸如以組分混合物形式、或同時或依次應用)。
在本公開的另一個實施方式中,式1可以與一種或多種活性成分組合使用(諸如以組分混合物形式、或同時或依次應用),該一種或多種活性成分各自具有與式1的作用模式(MoA)相同、類似、或較佳的是 - 不同的MoA。
在另一個實施方式中,式1可以與具有殺蜱蟎亞綱動物、殺藻、殺鳥、殺細菌、殺真菌、除草、殺昆蟲、殺軟體動物、殺線蟲、殺齧齒動物、和/或殺病毒特性的一種或多種分子組合使用(諸如以組分混合物形式、或同時或依次應用)。
在另一個實施方式中,式1可以與作為拒食劑、驅鳥劑、化學不育劑、除草劑安全劑、昆蟲引誘劑、驅昆蟲劑、驅哺乳動物劑、交配干擾劑、植物活化劑、植物生長調節劑、植物健康刺激劑或促進劑、硝化作用抑制劑,和/或增效劑的一種或多種分子組合使用(諸如以組分混合物形式、或同時或依次應用)。
在另一個實施方式中,式1也可以與一種或多種生物型殺有害生物劑組合使用(諸如以組分混合物形式、或同時或依次應用)。
在另一個實施方式中,在殺有害生物組成物中,式1和活性成分的組合可以廣泛多種重量比率使用。例如,在雙組分混合物中,式1與活性成分的重量比率可使用表1中的重量比率。然而,通常,小於約10 : 1至約1 : 10的重量比率係較佳的。
[表 1 ] |
式一 : 活性成分的重量比率 |
100 : 1至1 : 100 |
50 : 1至1 : 50 |
20 : 1至1 : 20 |
10 : 1至1 : 10 |
5 : 1至1 : 5 |
3 : 1至1 : 3 |
2 : 1至1 : 2 |
1 : 1 |
式1的分子與活性成分的重量比率也可描繪為X : Y;其中X係式1的重量份並且Y係活性成分的重量份。X的重量份的數值範圍為0 < X ≤ 100並且Y的重量份的數值範圍為0 < Y ≤ 100,並且圖表地示出於表2中。作為非限制性實例,式1與活性成分的重量比率可以是20 : 1。
[表 2 ] | ||||||||||
活性成分 (Y )重量份 | 100 | X , Y | X , Y | X , Y | ||||||
50 | X , Y | X , Y | X , Y | X , Y | X , Y | |||||
20 | X , Y | X , Y | X , Y | X , Y | X , Y | |||||
15 | X , Y | X , Y | X , Y | X , Y | X , Y | |||||
10 | X , Y | X , Y | ||||||||
5 | X , Y | X , Y | X , Y | X , Y | ||||||
3 | X , Y | X , Y | X , Y | X , Y | X , Y | X , Y | X , Y | |||
2 | X , Y | X , Y | X , Y | X , Y | X , Y | |||||
1 | X , Y | X , Y | X , Y | X , Y | X , Y | X , Y | X , Y | X , Y | X , Y | |
1 | 2 | 3 | 5 | 10 | 15 | 20 | 50 | 100 | ||
式一,也稱為F1 ,(X )重量份 |
式1與活性成分的重量比率的範圍可描繪為X1
:Y1
至X2
:Y2
,其中X
和Y
係如上定義的。
在一個實施方式中,重量比率的範圍可以是X1
:Y1
至X2
:Y2
,其中X1
>Y1
且X2
<Y2
。作為非限制性實例,式1與活性成分重量比率可以是3 : 1至1 : 3,包括端點。
在另一個實施方式中,重量比率的範圍可以是X1
:Y1
至X2
:Y2
,其中X1
>Y1
且X2
>Y2
。作為非限制性實例,式1與活性成分重量比率可以是15 : 1至3 : 1,包括端點。
在另一個實施方式中,重量比率的範圍可以是X1
:Y1
至X2
:Y2
,其中X1
<Y1
且X2
<Y2
。作為非限制性實例,式1與活性成分重量比率可以是約1 : 3至約1 : 20,包括端點。
本揭露之另一個實施方式係用於控制或預防真菌侵襲之方法。該方法包括向真菌的土壤、植物、根、葉或場所或要防止侵染的場所(例如,施用於穀物或葡萄植物)施用殺真菌有效量的一種或多種具有式I之化合物。該化合物適合於以殺真菌水平處理各種植物,同時表現出低的植物毒性。該等化合物可以以保護劑和/或根除劑的形式使用。
已經發現該化合物具有顯著的殺真菌作用,特別是用於農業用途。該化合物中的許多對農作物和園藝植物特別有效。
熟悉該項技術者將理解,化合物對前述真菌的功效確立了化合物作為殺真菌劑的一般用途。
該化合物對真菌病原體具有廣泛的活性。示例性病原體可包括但不限於以下的致病因子:小麥葉斑病的引發劑(Zymoseptoria tritici
)、小麥褐銹病(小麥葉鏽菌(Puccinia triticina
))、小麥條銹病(條形柄鏽菌(Puccinia striiformis
))、蘋果黑星病(蘋果黑星病菌(Venturia inaequalis
))、葡萄白粉病(葡萄白粉菌(Uncinula necator
))、雲紋病(大麥雲紋病菌(Rhynchosporium commune
))、稻瘟病(稻瘟病菌(Magnaporthe grisea
))、大豆銹病(大豆鏽菌(Phakopsora pachyrhizi
))、小麥穎斑枯病(Parastagonospora nodorum
)、小麥白粉病(Blumeria graminis f. sp. tritici
)、大麥白粉病(大麥白粉病菌(Blumeria graminis f. sp. hordei
))、葫蘆科白粉病(菊科白粉菌(Erysiphe cichoracearum
))、葫蘆科炭疽病(瓜炭疽病菌(Glomerella lagenarium
))、甜菜褐斑病(甜菜生尾孢(Cercospora beticola
))、番茄早疫病(番茄早疫病菌(Alternaria solani
))、大麥斑點病(禾旋孢腔菌(Cochliobolus sativus
))、和大麥網狀斑點病(圓核腔菌(Pyrenophora teres
))。所施加的活性物質的確切量不僅取決於所施加的特定活性物質,還取決於所需的特定作用、所要控制的真菌物種、其生長階段以及與該化合物接觸的植物的部分或其他產物。因此,所有化合物和含有該化合物的配製物在相似的濃度下或針對相同的真菌物種可能不能同樣有效。
該化合物以抑制疾病的量和植物學上可接受的量有效地與植物一起使用。術語「抑制疾病的量和植物學上可接受的量」係指殺死或抑制需要控制的植物病害但對植物無明顯毒性的化合物的量。該量通常為約0.1至約1000 ppm(百萬分率),較佳的是1至500 ppm。所需化合物的確切濃度隨要控制的真菌病害、所用配製物的類型、施用方法、特定植物物種、氣候條件等而變化。合適的施用率通常在約0.10至約4磅/英畝(約0.01至0.45克/平方米,g/m2
)的範圍內。
對於熟悉該項技術者對於理解本文的教導顯而易見的是,本文給出的任何範圍或期望值可以被擴展或改變而不會失去所尋求的效果。
具有式I之化合物可以使用熟知的化學方法製備。在本揭露中未具體提及的中間體係可商購的,可以藉由化學文獻中揭露的途徑製備,或者可以容易地使用標準程序由商業起始物質合成。通用方案
以下方案說明了產生具有式 (I) 的芳基脒化合物之方法。提供以下描述和實例用於說明性目的,並且不應解釋為對取代基或取代方式的限制。
具有式1.4的化合物(其中R2
、R3
、R4
和R5
係如最初定義的)可以藉由方案 1 ,步驟 a-c
中所示之方法製備。具有式1.2的化合物(其中R2 、
R4
和R5
係如最初定義的)可以藉由方案 1 ,步驟 a
中所示之方法製備。具有式1.1的化合物(其中R2 、
R4
和R5
係如最初定義的)可以在碘(I2
)的存在下,在溶劑(例如N
,N
-二甲基甲醯胺(DMF))中,在約23°C至50°C的溫度下,用過碘酸鈉處理以提供具有式1.2的化合物(其中R2 、
R4
和R5
係如最初定義的),如 a
中所示。具有式1.3的化合物(其中R2
、R3
、R4
和R5
係如最初定義的)可以藉由方案 1 ,步驟 b
中所示之方法製備。具有式1.2的化合物(其中R2 、
R4
和R5
係如最初定義的)可以在鹼(例如碳酸銫(Cs2
CO3
))的存在下,在溶劑(例如1,4-二㗁𠮿)中,在約23°C至120°C的溫度下,在微波輻射下,用催化劑(例如與二氯甲烷複合的[1,1’-雙(二苯基膦)二茂鐵]二氯化鈀(II)(PdCl2
(dppf)DCM)和硼酸酐(例如B3
O3
R3 3
(其中R3
係如最初定義的)))處理以提供具有式1.3的化合物(其中R2
、R3
、R4
和R5
係如最初定義的),如 b
中所示。具有式1.4的化合物(其中R2
、R3
、R4
和R5
係如最初定義的)可以藉由方案 1 ,步驟 c
中所示之方法製備。具有式1.3的化合物(其中R2
、R3
、R4
和R5
係如最初定義的)可以在溶劑混合物(例如3 : 2 : 1的四氫呋喃(THF): 甲醇(MeOH): 水(H2
O))中,在約23°C至70°C回流的溫度下,用鹼(例如氫氧化鋰(LiOH))處理以提供具有式1.4的化合物(其中R2
、R3
、R4
和R5
係如最初定義的),如 c
中所示。方案 1
可替代地,具有式1.4的化合物(其中R2
、R3
、R4
和R5
係如最初定義的)可以藉由方案 2 ,步驟 d-f
中所示之方法製備。具有式2.2的化合物(其中R2 、
R4
和R5
係如最初定義的)可以藉由方案 2 ,步驟 d
中所示之方法製備。具有式2.1的化合物(其中R2 、
R4
和R5
係如最初定義的)可以在溶劑(例如N
,N
-二甲基甲醯胺(DMF))中,在約0°C至23°C的溫度下,用鹵化試劑(例如N
-溴代琥珀醯亞胺(NBS))處理以提供的具有式2.2的化合物(其中R2 、
R4
和R5
係如最初定義的),如 d
中所示。具有式2.3的化合物(其中R2
、R3
、R4
和R5
係如最初定義的)可以藉由方案 2 ,步驟 e
中所示之方法製備。具有式2.2的化合物(其中R2 、
R4
和R5
係如最初定義的)可以在鹼(例如磷酸三鉀(K3
PO4
))的存在下,在溶劑混合物(例如10 : 1的1,4-二㗁𠮿 : 水)中,在約23°C至100°C的溫度下,用催化劑(例如(2-二環己基膦-2′,4′,6′-三異丙基-1,1′-聯苯基)[2-(2′-胺基-1,1′-聯苯基)]甲烷磺酸鈀(II)(XPhos-Pd-G3)
和硼酸酐(例如B3
O3
R3 3
(其中R3
係如最初定義的))處理以提供具有式2.3的化合物(其中R2
、R3
、R4
和R5
係如最初定義的),如 e
中所示的。具有式1.4的化合物(其中R2
、R3
、R4
和R5
係如最初定義的)可以藉由方案 2 ,步驟 f
中所示之方法製備。具有式2.3的化合物(其中R2
、R3
、R4
和R5
係如最初定義的)可以在溶劑(例如水)中,在約23°C至60°C的溫度下,用鹼(例如氫氧化鉀(KOH))處理以提供具有式1.4的化合物(其中R2
、R3
、R4
和R5
係如最初定義的),如 f
中所示的。方案 2
可替代地,具有式1.4的化合物(其中R2
、R3
、R4
和R5
係如最初定義的)可以藉由方案 3 ,步驟 g-n
中所示之方法製備。具有式3.2的化合物(其中R2
、R3
、R4
和R5
係如最初定義的)可以藉由方案 3 ,步驟 g
中所示之方法製備。具有式3.1的化合物(其中R2
、R3
、R4
和R5
係如最初定義的)可以在亞硝酸鈉(NaNO2
)的存在下,在溶劑(例如乙酸)中,在約23°C至85°C的溫度下,用溴化氫(HBr)處理以提供具有式3.2的化合物(其中R2
、R3
、R4
和R5
係如最初定義的),如 g
中所示的。具有式3.3的化合物(其中R2
、R3
、R4
和R5
係如最初定義的)可以藉由方案 3 ,步驟 h
中所示之方法製備。具有式3.2的化合物(其中R2
、R3
、R4
和R5
係如最初定義的)可以在銨鹽(例如氯化銨(NH4
Cl))的存在下,在溶劑混合物(例如1 : 1的乙醇(EtOH): H2
O)中,在約23°C至70°C的溫度下,用金屬催化劑(例如鐵(Fe0
)處理以提供具有式3.3的化合物(其中R2
、R3
、R4
和R5
係如最初定義的),如 h
中所示的。可替代地,具有式3.3的化合物(其中R2
、R3
、R4
和R5
係如最初定義的)可以藉由方案 3 ,步驟 i
中所示之方法製備。具有式3.4的化合物(其中R2
、R3
、R4
和R5
係如最初定義的)可以在溶劑(例如N
,N
-二甲基甲醯胺(DMF))中,在約0°C至23°C的溫度下,用鹵化試劑(例如N
-溴代琥珀醯亞胺(NBS))處理以提供具有式3.3的化合物(其中R2 、
R3
、R4
和R5
係如最初定義的),如 i
中所示的。具有式3.5的化合物(其中R2
、R3
、R4
和R5
係如最初定義的)可以藉由方案 3 ,步驟 j
中所示之方法製備。具有式3.3的化合物(其中R2
、R3
、R4
和R5
係如最初定義的)可以在溶劑(例如N
-甲基-2-吡咯啶酮(NMP))中,在約23°C至180°C的溫度下,在微波輻射下,用金屬氰化物(例如CuCN)處理以提供具有式3.5的化合物(其中R2
、R3
、R4
和R5
係如最初定義的),如 j
中所示的。可替代地,具有式3.5的化合物(其中R2
、R3
、R4
和R5
係如最初定義的)可以藉由方案 3 ,步驟 k
中所示之方法製備。具有式3.3的化合物(其中R2
、R3
、R4
和R5
係如最初定義的)可以在金屬催化劑(例如四(三苯基膦)-鈀(0)(Pd(PPh3
)4
)的存在下,在溶劑(例如DMF)中,在約23°C至120°C的溫度下,用金屬氰化物(例如氰化鋅(II)(Zn(CN)2
))處理以提供具有式3.4的化合物(其中R2
、R3
、R4
和R5
係如最初定義的),如 k
中所示的。具有式1.4的化合物(其中R2
、R3
、R4
和R5
係如最初定義的)可以藉由方案 3 ,步驟 l
中所示之方法製備。具有式3.5的化合物(其中R2
、R3
、R4
和R5
係如最初定義的)可以在溶劑(例如H2
O)中,在約23°C至120°C的溫度下,用鹼(例如氫氧化鉀(KOH))處理以提供具有式1.4的化合物(其中R2
、R3
、R4
和R5
係如最初定義的),如 l
中所示的。可替代地,具有式3.6的化合物(其中R2
、R3
、R4
和R5
係如最初定義的)可以藉由方案 3 ,步驟 m
中所示之方法製備。具有式3.3的化合物(其中R2
、R3
、R4
和R5
係如最初定義的)可以在金屬催化劑(例如乙酸鈀(II))的存在下,在配位基(例如1,4-雙(二苯基膦基)丁烷)與鹼(例如三乙胺(TEA))的存在下,在溶劑(例如甲醇)中,在約400 psi的壓力下和約23°C至125°C的溫度下,用一氧化碳(CO)氣體處理以提供具有式3.6的化合物(其中R2
、R3
、R4
和R5
係如最初定義的),如 m
中所示的。具有式1.4的化合物(其中R2
、R3
、R4
和R5
係如最初定義的)可以藉由方案 3 ,步驟 n
中所示之方法製備。具有式3.6的化合物(其中R2
、R3
、R4
和R5
係如最初定義的)可以在溶劑混合物(例如3 : 2 : 1的THF : MeOH : 水)中,在約23°C至125°C的溫度下,用鹼(例如氫氧化鋰(LiOH))處理以提供具有式1.4的化合物(其中R2
、R3
、R4
和R5
係如最初定義的),如 n
中所示的。方案 3
具有式4.1的化合物(其中R1
、R2
、R3
、R4
和R5
係如最初定義的)可以藉由方案 4 、步驟 o
中所示之方法製備。具有式1.4的化合物(其中R2
、R3
、R4
和R5
係如最初定義的)可以在肽偶合試劑(例如1-乙基-3-(3-二甲基胺基丙基)碳二亞胺(EDCI)、N
,N
’-二環己基碳二亞胺(DCC)或苯并三唑-1-基-氧三吡咯啶基鏻六氟磷酸酯(PyBOP))和催化劑(例如二甲胺基吡啶(DMAP)或N
-乙基-N
-異丙基丙-2-胺(DIPEA))的存在下,在溶劑(例如二氯甲烷(DCM))中,在約0°C至環境溫度的溫度下,用醇(例如R1
-OH(其中R1
係如最初定義的))處理以提供具有式4.1的化合物(其中R1
、R2
、R3
、R4
和R5
係如最初定義的),如 o
中所示的。可替代地,具有式4.1的化合物(其中R1
、R2
、R3
、R4
和R5
係如最初定義的)可以藉由方案 4 、步驟 p
中所示之方法製備。具有式1.4的化合物(其中R2
、R3
、R4
和R5
係如最初定義的)可以在鹼(例如碳酸鉀(K2
CO3
))的存在下,在溶劑(例如DMF)中,在約23°C的溫度下,用烷基化劑(例如R1
-Br(其中R1
係如最初定義的))處理以提供具有式4.1的化合物(其中R1
、R2
、R3
、R4
和R5
係如最初定義的),如 p
中所示的。方案 4
具有式5.2的化合物(其中R1
、R2
、R3
、R4
、R5
、R7
和R8
係如最初定義的)可以藉由方案 5 ,步驟 q
中所示之方法製備。具有式4.1的化合物(其中R1
、R2
、R3
、R4
和R5
係如最初定義的)可以在溶劑(例如甲苯)中,在約23°C至90°C的溫度下,用胺(例如具有式5.1的化合物(其中R7
和R8
係如最初定義的))處理以提供具有式5.2的化合物(其中R1
、R2
、R3
、R4
、R5
、R7
和R8
係如最初定義的),如 q
中所示的。方案 5
可替代地,具有式5.2的化合物(其中R1
、R2
、R3
、R4
、R5
、R7
和R8
係如最初定義的)可以藉由方案 6 、步驟 r-s
中所示之方法製備。具有式6.1的化合物(其中R1
、R2
、R3
、R4
和R5
係如最初定義的,並且Z係烷基基團)可以藉由方案 6 、步驟 r
中所示之方法製備。具有式4.1的化合物(其中R1
、R2
、R3
、R4
和R5
係如最初定義的)可以在酸催化劑(例如對甲苯磺酸水合物(pTsOH-H2
O))的存在下,在約回流的溫度(分別約100°C或約140°C)下,用原甲酸三烷基酯(CH(OZ)3
(其中Z係烷基基團,例如原甲酸三甲酯或原甲酸三乙酯))處理以提供具有式6.1的化合物(其中R1
、R2
、R3
、R4
和R5
係如最初定義的,並且Z係烷基基團),如 r
中所示的。具有式5.2的化合物(其中R1
、R2
、R3
、R4
、R5
、R7
和R8
係如最初定義的)可以藉由方案 6 、步驟 s
中所示之方法製備。具有式6.1的化合物(其中R1
、R2
、R3
、R4
和R5
係如最初定義的,並且Z係烷基基團)可以在溶劑(例如DCM)中,在約23°C至40°C的溫度下,用胺(例如具有式6.2的化合物(其中R7
和R8
係如最初定義的))處理以提供具有式5.2的化合物(其中R1
、R2
、R3
、R4
、R5
、R7
和R8
係如最初定義的),如 s
中所示的。方案 6
具有式7.2的化合物(其中R1
、R2
、R3
、R4
、R5
、R6
、R7
和R8
係如最初定義的)可以藉由方案 7 ,步驟 t
中所示之方法製備。具有式4.1的化合物(其中R1
、R2
、R3
、R4
、和R5
係如先前所定義的)可以在脫水試劑(例如三氯氧磷(POCl3
))的存在下,在溶劑(例如甲苯)中,在約23°C至回流(約110°C)的溫度下,用醯胺(例如具有式7.1的化合物(其中R6
、R7
和R8
係如最初定義的))處理以提供具有式7.2的化合物(其中R1
、R2
、R3
、R4
、R5
、R6
、R7
和R8
係如最初定義的),如 t
中所示的。方案 7
具有式8.2的化合物(其中R1
、R2
、R3
、R4
、R5
、R7
和R8
係如最初定義的)可以藉由方案 8 ,步驟 u-v
中所示之方法製備。具有式8.1的化合物(其中R1
、R2
、R3
、R4
和R5
係如最初定義的)可以藉由方案 8 ,步驟 u
中所示之方法製備。具有式4.1的化合物(其中R1
、R2
、R3
、R4
和R5
係如先前所定義的)可以在溶劑混合物(例如1 : 1的DCM : H2
O)中,在鹼的存在下(例如碳酸氫鈉(NaHCO3
)),在約23°C的溫度下,用硫光氣處理以提供具有式8.1的化合物(其中R1
、R2
、R3
、R4
和R5
係如先前所定義的),如 u
中所示的。具有式8.2的化合物(其中R1
、R2
、R3
、R4
、R5
、R7
和R8
係如最初定義的)可以藉由方案 8 ,步驟 v
中所示之方法製備。具有式8.1的化合物(其中R1
、R2
、R3
、R4
和R5
係如先前所定義的)可以在溶劑(例如DCM)中,在約23°C的溫度下,用胺(例如具有式6.2的化合物(其中R7
和R8
係如最初定義的))處理以提供具有式8.2的化合物(其中R1
、R2
、R3
、R4
、R5
、R7
和R8
係如最初定義的),如 v
中所示的。方案 8
可替代地,具有式9.3的化合物(其中R1
、R2
、R3
、R4
、R5
、R7
和R8
係如最初定義的)可以藉由方案 9 ,步驟 w-x
中所示之方法製備。具有式9.1的化合物(其中R1
、R2
、R3
、R4
和R5
係如最初定義的)可以藉由方案 9 ,步驟 w
中所示之方法製備。具有式4.1的化合物(其中R1
、R2
、R3
、R4
和R5
係如最初定義的)可以在酸催化劑(例如對甲苯磺酸水合物(pTsOH-H2
O))的存在下,在約回流(約100°C)的溫度下,用原甲酸三甲酯處理以提供具有式9.1的化合物(其中R1
、R2
、R3
、R4
和R5
係如最初定義的),如 w
中所示的。具有式9.3的化合物(其中R1
、R2
、R3
、R4
、R5
、R7
和R8
係如最初定義的)可以藉由方案 9 ,步驟 x
中所示之方法製備。具有式9.1的化合物(其中R1
、R2
、R3
、R4
和R5
係如最初定義的)可以在鹼(例如三乙胺)的存在下,在溶劑混合物(例如1 : 1的甲醇 : 1,4-二㗁𠮿)中,在約23°C至回流(約80°C)的溫度下,用胺(例如具有式9.2的化合物(其中R7
和R8
係如最初定義的))處理以提供具有式9.3的化合物(其中R1
、R2
、R3
、R4
、R5
、R7
和R8
係如最初定義的),如 x
中所示的。方案 9
具有式10.2的化合物(其中R2
、R3
、R4
、R5
、R6
、R7
和R8
係如最初定義的)可以藉由方案 10 ,步驟 y
中所示之方法製備。具有式10.1的化合物(其中R2
、R3
、R4
、R5
、R6
、R7
和R8
係如最初定義的)可以在溶劑(例如MeOH)中,在約23°C至60°C的溫度下,用鹼(例如氫氧化鈉(NaOH))處理以提供具有式10.2的化合物(其中R2
、R3
、R4
、R5
、R6
、R7
和R8
係如最初定義的),如 y
中所示的。方案 10
具有式11.1的化合物(其中R1
、R2
、R3
、R4
、R5
、R7
和R8
係如最初定義的)可以藉由方案 11 ,步驟 z
中所示之方法製備。具有式8.2的化合物(其中R1
、R2
、R3
、R4
、R5
、R7
和R8
係如最初定義的)可以在鹼(例如碳酸鉀(K2
CO3
))的存在下,在溶劑(例如丙酮)中,在約23°C的溫度下,用烷基化劑(例如碘甲烷)處理以提供具有式11.1的化合物(其中R1
、R2
、R3
、R4
、R5
、R7
和R8
係如最初定義的),如 z
中所示的。方案 11
具有式12.1的化合物(其中R1
、R2
、R3
、R4
、R5
、R7
和R8
係如最初定義的)可以藉由方案 12 ,步驟 aa
中所示之方法製備。具有式5.2的化合物(其中R1
、R2
、R3
、R4
、R5
、R7
和R8
係如最初定義的)可以在溶劑(例如庚烷或乙酸乙酯)中,在約23°C的溫度下,用質子酸(HX)(例如鹽酸(HCl)、氫溴酸(HBr)、乙酸(HOAc)、三氟乙酸、對甲苯磺酸(pTsOH)、或檸檬酸)處理以提供具有式12.1的化合物(其中R1
、R2
、R3
、R4
、R5
、R7
和R8
係如最初定義的),如 aa
中所示的。方案 12 實例 實例 1A : 4- 胺基 -5- 碘 -2- 甲基苯甲酸甲酯的製備。
向4-胺基-2-甲基苯甲酸甲酯(0.29 g,1.76 mmol)在DMF(1.5 mL)中的溶液中分別添加過碘酸鈉(0.14 g,0.70 mmol)和I2
(74 mg,1.41 mmol)。將反應混合物在50°C攪拌3 h。將反應混合物用飽和硫代硫酸鈉溶液(5 mL)稀釋。然後將固體過濾並乾燥。將粗產物與EtOAc(1 mL)和戊烷(9 mL)一起研磨,以提供呈粉紅色固體的標題化合物(0.22 g,43%產率):1
H NMR (400 MHz, CDCl3
) δ 8.27 (s, 1H), 6.54 (s, 1H), 4.38 (brs, 2H), 3.84 (s, 3H), 2.50 (s, 3H); ESIMSm/z
292 ([M+H]+
)。實例 1B : 4- 乙醯胺基 -5- 溴 -2- 甲氧基苯甲酸甲酯的製備。
在0°C下,向4-乙醯胺基-2-甲氧基苯甲酸甲酯(4.04 g,18.1 mmol)在DMF(80 mL)中的溶液中添加N-溴代琥珀醯亞胺(3.22 g,18.1 mmol)。將混合物在0°C下攪拌,並在攪拌過夜的同時使其緩慢升溫至室溫。然後將混合物用水稀釋,並形成沈澱。濾出沈澱物,並用另外的水洗滌。將沈澱物在真空下乾燥,得到不純的產物。將粗產物藉由快速柱層析法(矽膠(SiO2
),在己烷中的0à100%乙酸乙酯溶液)純化以提供呈白色固體的標題化合物(3.89 g,12.9 mmol,71%產率):1
H NMR (400 MHz, CDCl3
) δ 8.32 (s, 1H), 8.04 (s, 1H), 7.76 (s, 1H), 3.93 (s, 3H), 3.87 (s, 3H), 2.28 (s, 3H);13
C NMR (101 MHz, CDCl3
) δ 166.28, 162.47, 157.58, 137.80, 132.74, 113.36, 102.13, 99.53, 54.06, 49.79, 22.92; ESIMSm/z
304 [(M+H)+
]。實例 1C : 4- 溴 -5- 甲基 -2-( 三氟甲基 ) 苯胺的製備。
在25 mL的小瓶中,製備5-甲基-2-(三氟甲基)苯胺(1.00 g,5.71 mmol)在DMF(18 mL)中的溶液。在冰水浴中將反應冷卻至0°C。然後一次性添加N
-溴代琥珀醯亞胺(1.02 g,5.71 mmol)。將反應攪拌過夜,隨著冰融化緩慢升溫至環境溫度。18小時後,將反應用水(50 mL)淬滅,並用EtOAc(50 mL)稀釋。分離各層,並將水層用EtOAc(3 x 50 mL)萃取。然後將合併的有機層用鹽水(3 x 100 mL)洗滌,經MgSO4
乾燥,過濾並濃縮以提供呈深黃色油狀物的標題化合物(1.31 g,5.16 mmol,90%產率),其無需進一步純化即可使用:1
H NMR (400 MHz, CDCl3
) δ 7.54 (s, 1H), 6.63 (s, 1H), 4.09 (s, 2H), 2.32 (s, 3H);19
F NMR (376 MHz, CDCl3
) δ - 62.58;對於C8
H8
BrF3
N計算的HRMS-ESI (m/z
) [M+H]+
為253.9787;實測值為253.9778。實例 2A : 4- 胺基 -2,5- 二甲基苯甲酸甲酯的製備。
向4-胺基-5-碘-2-甲基苯甲酸甲酯(0.22 g,0.75 mmol)在1,4-二㗁𠮿(5 mL)中的溶液中添加碳酸銫(0.98 g,3.02 mmol),然後脫氣5分鐘。然後添加PdCl2
(dppf)DCM(0.061 g,0.07 mmol)和三甲基環三硼氧烷(0.23 g,1.88 mmol),並將反應混合物在微波輻射下加熱至120°C保持1 h。將反應混合物用水(15 mL)稀釋,並用EtOAc(2 × 40 mL)萃取。將合併的有機層經無水Na2
SO4
乾燥,過濾並在減壓下濃縮。將粗產物藉由快速柱層析法(矽膠(SiO2
),在己烷中的20%à25%乙酸乙酯溶液)純化以提供呈褐色固體的標題化合物(0.11 g,84%產率):ESIMSm/z
180 ([M+H]+
)。實例 2B : 4- 乙醯胺基 -2- 甲氧基 -5- 甲基苯甲酸甲酯的製備。
將4-乙醯胺基-5-溴-2-甲氧基苯甲酸甲酯(2.00 g,6.62 mmol)、甲基硼酸(0.594 g,9.93 mmol)、XPhosPd G3(0.112 g,0.132 mmol)、和磷酸三鉀(2.81 g,13.2 mmol)溶解/懸浮於1,4-二㗁𠮿(30.1 mL)/水(3.01 mL)中,並加熱至100°C。將混合物在100°C下攪拌4 h。將該混合物冷卻至室溫(UPLC顯示約50%轉化率),用DCM和水稀釋。然後使混合物通過相分離器,並用DCM萃取產物。將粗產物藉由快速柱層析法純化(矽膠(SiO2
),在己烷中的0à100%乙酸乙酯溶液)以提供呈白色固體的標題化合物(658 mg,2.77 mmol,42%產率)和866 mg(43%)回收的起始物質:1
H NMR (400 MHz, CDCl3
) δ 8.01 (s, 1H), 7.70 - 7.63 (m, 1H), 7.11 (s, 1H), 3.90 (s, 3H), 3.87 (s, 3H), 2.25 (s, 3H), 2.22 (s, 3H);13
C NMR (101 MHz, CDCl3
) δ 167.27, 165.10, 157.74, 139.71, 132.51, 131.72, 115.99, 103.58, 55.11, 50.80, 23.93, 15.45; ESIMSm/z
236 [(M-H)-
]。實例 3A : 4- 胺基 -2,5- 二甲基苯甲酸的製備。
向4-胺基-2,5-二甲基苯甲酸甲酯(0.11 g,0.69 mmol)在THF : MeOH : H2
O(3 : 2 : 1)(2 mL)中的溶液中添加LiOH(0.073 mg,3.07 mmol),並將反應混合物在70°C下攪拌16 h。然後將反應混合物用乙酸(0.5 mL)酸化。過濾並乾燥沈澱出的固體,以提供呈淡黃色固體的標題化合物(0.062 g,68%產率):1
H NMR (400 MHz, CDCl3
) δ 7.82 (s, 1H), 6.48 (s, 1H), 3.97 (brs, 2H), 2.54 (s, 3H), 2.14 (s, 3H); ESIMSm/z
166 ([M+H]+
)。實例 3B : 4- 胺基 -2- 甲氧基 -5- 甲基苯甲酸的製備。
在50 mL的圓底燒瓶中,將4-乙醯胺基-2-甲氧基-5-甲基苯甲酸甲酯(0.658 g,2.77 mmol)溶解/懸浮在6 M KOH水溶液中。在室溫下向懸浮液中添加MeOH(5 mL)。然後將混合物加熱至60°C並攪拌過夜。將反應冷卻至室溫,用水稀釋,並用6N HCl(逐滴)小心酸化至pH約4-5。將產物用EtOAc萃取(3x)。然後將合併的有機層用Na2
SO4
乾燥,過濾並濃縮,以提供呈灰白色固體的標題化合物(437 mg,2.41 mmol,87%產率):1
H NMR (500 MHz, CDCl3
) δ 7.84 (s, 1H), 6.25 (s, 1H), 4.19 (s, 3H), 3.98 (s, 3H), 2.11 (s, 3H);13
C NMR (126 MHz, CDCl3
) δ 165.97, 158.27, 151.07, 135.66, 115.42, 106.65, 96.62, 56.49, 16.15; ESIMSm/z
182 [(M+H)+
]。實例 4 : 1- 溴 -5- 氯 -2- 甲基 -4- 硝基苯的製備。
在室溫下,向5-氯-2-甲基-4-硝基苯胺(5.3 g,28.49 mmol)在乙酸(53 mL)中的溶液中添加HBr水溶液(7.7 mL)。然後經45分鐘添加NaNO2
(1.96 g,28.49 mmol)。將反應混合物在85°C攪拌2 h。2 h後,將反應混合物冷卻至室溫,並倒入冰水(100 mL)中。過濾獲得的固體,用水(100 mL)洗滌,乾燥,以提供呈淡黃色固體的標題化合物(5.5 g,74%產率):1
H NMR (400 MHz, CDCl3
) δ 7.79 (s, 1H), 7.52 (s, 1H), 2.45 (s, 3H)。實例 5 : 4- 溴 -2- 氯 -5- 甲基苯胺的製備。
在室溫下,將Fe0
粉(12.1 g,220.8 mmol)和NH4
Cl(11.7 g,220.8 mmol)添加到1-溴-5-氯-2-甲基-4-硝基苯(5.5 g,22.08 mmol)在EtOH : H2
O(55 mL,1 : 1)的溶液中。將反應混合物在70°C下攪拌30 min。然後將反應混合物冷卻至室溫,並在減壓下濃縮溶劑。用水(30 mL)稀釋粗物質,過濾,並用EtOAc(30 mL)洗滌固體。用EtOAc(2 x 30 mL)萃取水層。將合併的有機層經無水Na2
SO4
乾燥,過濾並在減壓下濃縮。將粗產物經由快速柱層析法(矽膠(SiO2
),在石油醚中的3%à5%乙酸乙酯溶液)純化以提供呈灰白色固體的標題化合物(2.8 g,58%產率):1
H NMR (400 MHz, DMSO-d 6
) δ 7.38 (s, 1H), 6.65 (s, 1H), 3.96 (brs, 2H), 2.27 (s, 1H); ESIMSm/z
220 ([M+H]+
)。實例 6A : 4- 胺基 -2,5- 二氯苄腈的製備。
向4-溴-2,5-二氯苯胺(2 g,8.33 mmol)在NMP(20 mL)中的溶液中添加CuCN(2.2 g,24.99 mmol),並將反應混合物在微波輻射下加熱至180°C持續1.5 h。將反應混合物倒入冰冷的水(30 mL)中,並用EtOAc(3 x 60 mL)萃取。將有機層經無水Na2
SO4
乾燥,過濾並在減壓下濃縮,以獲得粗產物。將粗產物藉由柱層析法(矽膠(SiO2
),在石油醚中的15%à20%乙酸乙酯溶液)純化以提供呈淡黃色固體的標題化合物(1 g,64%產率):1
H NMR (400 MHz, CDCl3
) δ 7.83 (s, 1H), 6.92 (s, 1H), 6.73 (brs, 2H); ESIMSm/z
187 ([M+H]+
)。實例 6B : 4- 胺基 -2,5- 二甲基苄腈的製備。
將4-溴-2,5-二甲基苯胺(15 g,75.00 mmol)和Zn(CN)2
(9.6 g,82.50 mmol)在DMF(150 mL)中的溶液脫氣10 min。然後添加四(三苯基膦)-鈀(0)(12.9 g,11.25 mmol),並將反應混合物在密封管中加熱至120°C保持2天。2天後,將反應混合物倒入冰冷的水(400 mL)中,並用EtOAc(3 × 600 mL)萃取。將合併的有機層經無水Na2
SO4
乾燥,過濾並在減壓下濃縮。將粗產物藉由柱層析法(矽膠(SiO2
),在石油醚中的15%à20%乙酸乙酯溶液)純化以提供呈淡黃色固體的標題化合物(5.7 g,52%產率):1
H NMR (400 MHz, CDCl3
) δ 7.25 (s, 1H), 6.50 (s, 1H), 3.98 (brs, 2H), 2.40 (s, 3H), 2.11 (s, 3H); ESIMSm/z
147 ([M+H]+
)。實例 6C :
4-胺基-5-甲氧基-2-甲基苯甲酸甲酯的製備。
在45 mL Parr反應器中製備4-溴-2-甲氧基-5-甲基苯胺(2.0 g,9.3 mmol)、乙酸鈀(II)(0.302 g,1.345 mmol)、1,4-雙(二苯基膦基)丁烷(1.19 g,2.79 mmol)和三乙胺(2.6 mL,19 mmol)在MeOH(20 mL)中的溶液。密封反應器並用CO吹掃(3個循環至50-100 psi)。然後用CO填充反應器至400 psi,將其置於加熱塊中,並加熱至130°C持續24 h。濃縮粗物質,並將粗殘餘物溶解於水(10 mL)和EtOAc(40 mL)中,並通過矽藻土過濾。用EtOAc(3 x 20 mL)萃取水層。將合併的有機層用鹽水(10 mL)洗滌,經MgSO4
乾燥,過濾並濃縮。將粗產物藉由柱層析法(矽膠(SiO2
),在石油醚中的0à40%乙酸乙酯)純化以提供呈玫瑰紅色固體的標題化合物(363 mg,20%產率):1
H NMR (400 MHz, CDCl3
) δ 7.42 (s, 1H), 6.50 (s, 1H), 4.12 (s, 2H), 3.87 (s, 3H), 3.84 (s, 3H), 2.49 (s, 3H); ESIMSm/z
196 ([M+H]+
)。實例 7A : 4- 胺基 -2,5- 二氯苯甲酸的製備。
在室溫下向4-胺基-2,5-二氯苄腈(1 g,5.37 mmol)在水(10 mL)中的溶液中添加KOH(6.0 g,107.52 mmol),並將反應混合物在密封管中加熱至120°C持續2天。2天後,將反應混合物用EtOAc(2 × 25 mL)萃取。將水層用乙酸(12 mL)酸化,並用10% MeOH(在DCM中)(2 × 75 mL)萃取。合併的有機層經無水Na2
SO4
乾燥,過濾並在減壓下濃縮,以提供呈淡黃色固體的標題化合物(0.7 g,63%產率),其無需進一步純化即可用於下一步驟:1
H NMR (400 MHz, CDCl3
) δ 7.61 (s, 1H), 6.77 (s, 1H), 5.89 (brs, 2H); ESIMSm/z
206 ([M+H]+
)。實例 7B : 4- 胺基 -5- 甲氧基 -2- 甲基苯甲酸的製備。
製備4-胺基-5-甲氧基-2-甲基苯甲酸甲酯(155 mg,0.794 mmol)和氫氧化鋰(86 mg,3.6 mmol)在3 : 2 : 1的THF : MeOH : 水(2.4 mL)中的溶液。將得到的深紫色反應在70°C下攪拌過夜。然後小心地添加1M HCl以將反應酸化至約pH = 4,並沈澱出固體。用EtOAc(3 x 30 mL)萃取水層。將合併的有機層經無水MgSO4
乾燥,過濾並在減壓下濃縮,以提供呈深綠色固體的標題化合物(92 mg,64%產率),其無需進一步純化即可用於下一步驟:1
H NMR (400 MHz, DMSO-d 6
) δ 11.95 (s, 1H), 7.29 (s, 1H), 6.44 (s, 1H), 5.40 (s, 2H), 3.75 (s, 3H), 2.37 (s, 3H);13
C NMR (126 MHz, DMSO-d 6
) δ 168.71, 143.69, 142.34, 134.93, 116.12, 115.89, 113.25, 55.76, 21.98; IR(薄膜)3500, 3396, 2935, 2836, 1669, 1608, 1529, 1451, 1364, 1258, 1217, 1081, 1022, 867 cm-1
; 對於C9
H12
NO3
計算的HRMS-ESI (m/z
) [M+H]+
為182.0812; 實測值為182.0812。實例 8A : 1-( 對甲苯基 ) 丙 -1- 醇的製備。
在250 mL燒瓶中,製備4-甲基苯甲醛(0.736 mL,6.24 mmol)在二乙醚(31.2 mL)中的溶液,並在冰浴中冷卻至0°C。經5分鐘向該澄清溶液中逐滴添加溴化乙基鎂(在THF中1M,7.49 mL,7.49 mmol),並將得到的溶液攪拌過夜,隨著冰浴融化緩慢升溫至室溫。18 h後,TLC表明起始物質消耗,並轉化為極性更大的產物。用飽和NH4
Cl水溶液(50 mL)淬滅反應,並用二乙醚(3 x 50 mL)萃取。合併的有機層通過相分離器並濃縮至澄清油狀物。將粗物質藉由快速柱層析法(矽膠(SiO2
),在己烷中的0à50%乙酸乙酯溶液)純化以提供呈澄清無色油狀物的標題化合物(476 mg,1.89 mmol,51%產率):1
H NMR (500 MHz, CDCl3
) δ 7.24 - 7.20 (m, 2H), 7.15 (d,J
= 7.9 Hz, 2H), 4.54 (ddd,J
= 7.0, 4.7, 1.6 Hz, 1H), 2.34 (s, 3H), 1.88 - 1.68 (m, 3H), 0.90 (t,J
= 7.4 Hz, 3H);13
C NMR (126 MHz, CDCl3
) δ 141.64, 137.15, 129.08, 125.93, 75.89, 31.80, 21.11, 10.20; IR(薄膜)3340, 2962, 2926, 1454, 1097, 1039, 1012, 815 cm-1
。實例 8B : (R)-1-( 對甲苯基 ) 乙 -1- 醇的製備。
在100 mL燒瓶中,製備1-(對甲苯基)乙-1-酮(0.747 mL,5.59 mmol)和(S)-1-甲基-3,3-二苯基四氫-1H,3H-吡咯[1,2-c][1,3,2]㗁唑硼烷((S
)-CBS催化劑,1M的甲苯溶液,1.118 mL,1.118 mmol)在甲苯(37.3 mL)中的溶液,並在冰/水浴中冷卻至0°C。然後經2分鐘經由注射器添加BH3
-DMS(在THF中2M,3.49 mL,6.99 mmol),並除去冰浴。將反應在室溫下攪拌。1 hr後,TLC表明起始物質消耗。緩慢添加甲醇(2.27 mL,55.9 mmol),並將反應濃縮以提供澄清無色油狀物。將粗物質藉由快速柱層析法(矽膠(SiO2
),在己烷中的0à50%乙酸乙酯溶液)純化以提供呈澄清無色油狀物的標題化合物(784 mg,5.76 mmol,量子產率):1
H NMR (500 MHz, CDCl3
) δ 7.26 (d,J
= 8.0 Hz, 2H), 7.16 (d,J
= 7.9 Hz, 2H), 4.86 (qd,J
= 6.4, 2.7 Hz, 1H), 2.34 (s, 3H), 1.78 (d,J
= 3.1 Hz, 1H), 1.48 (d,J
= 6.5 Hz, 3H);13
C NMR (126 MHz, CDCl3
) δ 142.88, 137.16, 129.17, 125.35, 70.26, 25.08, 21.09; IR(薄膜)3341, 2971, 1513, 1071, 1009, 897, 816 cm-1
。實例 9A : 4- 甲基苄基 4- 胺基 -2,5- 二甲基苯甲酸酯的製備。
在20 mL小瓶中,將對甲苯基甲醇(222 mg,1.82 mmol)、4-胺基-2,5-二甲基苯甲酸(150 mg,0.908 mmol)和DMAP(11.1 mg,0.091 mmol)溶解於DCM(4.45 mL)中並在冰/水浴中冷卻至0°C。約5 min後,一次性添加EDC(211 mg,1.36 mmol),並將所得淡黃色反應攪拌過夜,隨著冰融化緩慢升溫至室溫。18 h後,TLC表明起始物質消耗。將反應濃縮,以提供油狀物。將粗物質藉由快速柱層析法(C18反相,在水中的50%à100%乙腈溶液)純化以提供呈灰白色半固體的標題化合物(192 mg,0.712 mmol,78%產率):1
H NMR (400 MHz, CDCl3
) δ 7.74 (s, 1H), 7.36 - 7.29 (m, 2H), 7.18 (d,J
= 7.8 Hz, 2H), 6.46 (s, 1H), 5.25 (s, 2H), 3.88 (s, 2H), 2.52 (s, 3H), 2.36 (s, 3H), 2.12 (s, 3H);13
C NMR (101 MHz, CDCl3
) δ 167.17, 148.26, 140.79, 137.70, 133.84, 133.80, 129.17, 128.24, 118.63, 117.06, 77.22, 65.78, 21.98, 21.20, 16.59;對於C17
H20
NO2
計算的HRMS-ESI (m/z
) [M+H]+
為270.1489;實測值為270.1477。實例 9B : 2- 甲基苄基 4- 胺基 -2,5- 二甲基苯甲酸酯的製備。
分別向4-胺基-2,5-二甲基苯甲酸(4.2 g,25.45 mmol)在DMF(40 mL)中的溶液中添加1-(溴甲基)-2-甲苯(3.5 mL,25.45 mmol)和K2
CO3
(3.8 g,27.99 mmol)。將反應混合物在室溫下攪拌3小時。然後將反應混合物倒入冰冷水(100 mL)中,並用EtOAc(2 × 200 mL)萃取。將合併的有機層經無水Na2
SO4
乾燥,過濾並在減壓下濃縮。將粗產物藉由快速柱層析法(矽膠(SiO2
),在己烷中的10%à15%乙酸乙酯溶液)純化以提供呈灰白色固體的標題化合物(3.8 g,55%產率):1
H NMR (400 MHz, CDCl3
) δ 7.74 (s, 1H), 7.40 (d, 1H), 7.20 (m, 3H), 6.47 (s, 1H), 5.29 (s, 2H), 3.89 (brs, 2H), 2.52 (s, 3H), 2.40 (s, 3H), 2.11 (s, 3H); ESIMSm/z
270 ([M+H]+
)。實例 9C : 1-( 對甲苯基 ) 丙基 4- 胺基 -2,5- 二甲基苯甲酸酯的製備。
向含有4-胺基-2,5-二甲基苯甲酸(200 mg,1.21 mmol)的20 mL小瓶中添加2-(對甲苯基)丙-2-醇(364 mg,2.42 mmol)和PyBOP(945 mg,1.82mmol)。經45秒滴加DCM(12.1 mL),然後滴加N
-乙基-N
-異丙基丙-2-胺(844 μl,4.84 mmol)。10分鐘後,大多數固體溶解,並將所得的淡粉紅色反應在室溫下攪拌過夜。18 h後,將反應過濾並濃縮至棕色油狀物。將粗物質藉由快速柱層析法(C18反相,在水中的50%à100%乙腈溶液)純化以提供呈橙色油狀物的標題化合物(107 mg,0.36 mmol,30%產率):1
H NMR (500 MHz, CDCl3
) δ 7.77 (s, 1H), 7.33 7.27 (m, 2H), 7.18 7.10 (m, 2H), 6.44 (s, 1H), 5.82 (t,J
= 6.8 Hz, 1H), 3.87 (s, 2H), 2.51 (s, 3H), 2.32 (s, 3H), 2.14 (s, 3H), 2.03 (dt,J
= 13.7, 7.5 Hz, 1H), 1.90 (tt,J
= 13.7, 7.4 Hz, 1H), 0.94 (t,J
= 7.4 Hz, 3H);13
C NMR (126 MHz, CDCl3
) δ 166.70, 148.20, 140.65, 138.30, 137.17, 133.76, 129.02, 126.50, 118.97, 118.60, 117.06, 76.92, 29.66, 22.08, 21.14, 16.70, 10.17; IR(薄膜)3376, 2967, 2927, 1689, 1624, 1562, 1253, 1156, 1053, 814 cm-1
; 對於C19
H24
NO2
計算的HRMS-ESI (m/z
) [M+H]+
為298.1802;實測值為298.1801。實例 10A : 4- 甲基苄基 (E)-4-((( 乙基 ( 甲基 ) 胺基 ) 亞甲基 ) 胺基 )-2,5- 二甲基苯甲酸酯的製備。
在100 mL圓底燒瓶中,製備4-甲基苄基4-胺基-2,5-二甲基苯甲酸酯(359 mg,1.33 mmol)在甲苯(26.6 mL)中的溶液。然後添加N
-(二甲氧基甲基)N
-甲基乙胺(532 mg,4.00 mmol),並且將所得溶液配備回流冷凝器,加熱至80°C並攪拌48 h。48 h後,將溶液濃縮至油狀物。將粗物質藉由快速柱層析法(C18反相,在水中的30%à100%乙腈溶液)純化以提供呈棕色油狀物的標題化合物(333 mg,0.98 mmol,74%產率):1
H NMR (400 MHz, CDCl3
) δ 7.79 (s, 1H), 7.45 (s, 1H), 7.33 (d,J
= 7.9 Hz, 2H), 7.17 (d,J
= 7.8 Hz, 2H), 6.56 (s, 1H), 5.26 (s, 2H), 3.39 (bd,J
= 67.1 Hz, 2H), 2.99 (s, 3H), 2.55 (s, 3H), 2.35 (s, 3H), 2.22 (s, 3H), 1.20 (t,J
= 7.1 Hz, 3H);13
C NMR (101 MHz, CDCl3
) δ 167.49, 154.64, 151.69, 139.49, 137.70, 133.73, 132.81, 129.17, 128.79, 128.27, 122.55, 121.90, 65.92, 47.85, 32.02, 21.80, 21.18, 17.41, 14.37; ESIMSm/z
339 [(M+H)+
]。實例 10B : 4- 甲基苄基 (E)-4-((( 二乙基胺基 ) 亞甲基 ) 胺基 )-2,5- 二甲基苯甲酸酯的製備。
在20 mL小瓶中,將4-甲基苄基4-胺基-2,5-二甲基苯甲酸酯(100 mg,0.37 mmol)溶解於原甲酸三乙酯(2 mL,12.00 mmol)中,然後添加對甲苯磺酸一水合物(7.06 mg,0.03 mmol)。將反應加熱至回流(140°C)並攪拌3小時。3 h後,TLC表明起始物質幾乎完全消耗。用飽和NaHCO3
水溶液(10 mL)淬滅反應,並用DCM(3 x 10 mL)萃取。合併的有機相通過相分離器並濃縮至淡黃色油狀物。將殘餘物重新溶解於DCM(0.371 mL)中,並經由注射器逐滴添加二乙胺(0.058 mL,0.55 mmol)。將該溶液加熱至40°C並攪拌3小時。用水(10 mL)淬滅反應,並用DCM(3 x 10 mL)萃取。合併的有機相通過相分離器並濃縮。將粗物質藉由快速柱層析法(C18反相,在水中的30%à100%乙腈溶液)純化以提供呈棕色油狀物的標題化合物(75.8 mg,0.21 mmol,58%產率):1
H NMR (500 MHz, CDCl3
) δ 7.79 (t,J
= 1.4 Hz, 1H), 7.42 (s, 1H), 7.38 7.30 (m, 2H), 7.18 (dt,J
= 6.6, 1.7 Hz, 2H), 6.55 (s, 1H), 5.26 (s, 2H), 3.40 (d,J
= 94.6 Hz, 4H), 2.55 (s, 3H), 2.36 (s, 3H), 2.22 (s, 3H), 1.22 (t,J
= 7.1 Hz, 6H); IR(薄膜)2970, 2927, 1707, 1629, 1592, 1549, 1371, 1250, 1110, 1047 cm-1
; 對於C22
H29
N2
O2
計算的HRMS-ESI (m/z
) [M+H]+
為353.2224;實測值為353.2227。實例 10C : 4- 甲基苄基 (E)-2,5- 二甲基 -4-( 哌啶 -2- 基亞基胺基 ) 苯甲酸酯的製備。
在20 mL的小瓶中,在N2
下製備哌啶-2-酮(0.103 mL,1.11 mmol)在甲苯(9 mL)中的溶液。然後添加三氯化磷(0.052 mL,0.55 mmol),並將渾濁的反應在室溫下攪拌2 h。然後添加4-甲基苄基-4-胺基-2,5-二甲基苯甲酸酯(150 mg,0.55 mmol),並在反應中安裝回流冷凝器,並在回流(110℃)下加熱3 h。然後將所得的澄清的金色反應冷卻至室溫,用10% NaOH水溶液中和至pH 7,並用甲苯(20 mL)稀釋。將粗反應攪拌過夜。分離各層,並將水層用乙酸乙酯(3 x 20 mL)洗滌。將合併的有機層用鹽水洗滌,經Na2
SO4
乾燥,過濾,並濃縮至油狀物。使用SCX柱(用DCM、DMF、MeOH平衡)純化粗物質。將該物質載入到DCM中,並用DCM和MeOH沖洗該柱以洗脫不希望的組分。用在MeOH中的7N NH3
沖洗SCX柱,得到呈黃色油狀物的標題化合物(95.0 mg,0.27 mmol,49%產率):1
H NMR (600 MHz, CDCl3
) δ 7.79 (s, 1H), 7.34 (d,J
= 7.8 Hz, 2H), 7.19 (d,J
= 7.8 Hz, 2H), 6.63 (s, 1H), 5.27 (s, 2H), 4.39 (s, 1H), 3.22 (d,J
= 100.6 Hz, 2H), 2.59 (d,J
= 31.6 Hz, 2H), 2.52 (s, 3H), 2.36 (s, 3H), 2.07 (s, 3H), 1.76 (dh,J
= 8.3, 4.0, 3.3 Hz, 4H);13
C NMR (151 MHz, CDCl3
) δ 167.43, 155.09, 152.08, 139.70, 137.84, 133.52, 133.42, 129.21, 128.35, 127.29, 125.05, 123.33, 66.08, 42.55, 30.85, 23.06, 21.70, 21.22, 21.14, 17.02; ESIMSm/z
351 [(M+H)+
]。實例 10D : 4- 甲基苄基 4(3,3- 二乙基硫脲基 )-2,5- 二甲基苯甲酸酯的製備。
在20 mL小瓶中,製備4-甲基苄基4-胺基-2,5-二甲基苯甲酸酯(100 mg,0.37 mmol)和碳酸氫鈉(312 mg,3.71 mmol)在DCM(1.24 mL)和水(1.24 mL)中的溶液。經由注射器向該溶液中逐滴添加硫光氣(31.3 µL,0.40 mmol)。將得到的橙色兩相混合物在室溫下劇烈攪拌2 h。2 h後,TLC顯示起始物質完全消耗。將兩相混合物用水(5 mL)和DCM(5 mL)稀釋,通過相分離器,並濃縮以提供淡黃色油狀物。將粗物質重新溶解於DCM(1.24 mL)中,並且然後經由注射器一次性添加二乙胺(77 μL,0.74 mmol)。將所得溶液在室溫下攪拌1 h。1 h後,將溶液濃縮至油狀物。將粗物質藉由快速柱層析法(矽膠(SiO2
),在己烷中的0à50%乙酸乙酯溶液)純化以提供呈白色半固體的標題化合物(140.0 mg,0.36 mmol,98%產率):1
H NMR (400 MHz, CDCl3
) δ 7.81 (s, 1H), 7.36 - 7.28 (m, 2H), 7.23 - 7.15 (m, 3H), 6.75 (s, 1H), 5.27 (s, 2H), 3.76 (q,J
= 7.1 Hz, 4H), 2.54 (s, 3H), 2.36 (s, 3H), 2.23 (s, 3H), 1.31 (t,J
= 7.1 Hz, 6H);13
C NMR (101 MHz, CDCl3
) δ 180.90, 167.00, 141.68, 138.92, 138.00, 133.26, 133.19, 130.80, 129.63, 129.26, 128.37, 127.11, 66.42, 45.82, 21.54, 21.21, 17.59, 12.70; IR(薄膜)3240, 2974, 1713, 1516, 1258, 1141, 1055, 806, 728 cm-1
; 對於C22
H29
N2
O2
S計算的HRMS-ESI (m/z
) [M+H]+
為385.1944;實測值為385.1950。實例 10E : 2- 甲基苄基 (Z)-4-(( 甲氧基 ( 甲基胺基 ) 亞甲基 ) 胺基 )-2,5- 二甲基苯甲酸酯的製備。
將2-甲基苄基4-胺基-2,5-二甲基苯甲酸酯(0.22 g,0.81 mmol)在原甲酸三甲酯(6 mL)中的溶液在120°C下回流16 h。然後將反應混合物在減壓下濃縮,以提供0.22 g的呈淡黃色膠狀液體的粗品2-甲基苄基4-((甲氧基亞甲基)胺基)-2,5-二甲基苯甲酸酯。然後將粗物質溶解在1,4-二㗁𠮿(3 mL)和甲醇(3 mL)中。向該溶液中添加N
,O
-二甲基羥胺鹽酸鹽(0.97 g,0.71 mmol)和三乙胺(0.09 mL,0.71 mmmol)。然後將反應混合物在密封管中在80°C下攪拌16 h。將反應混合物在減壓下濃縮,以提供粗物質。經由製備型HPLC純化該物質,以提供呈灰白色固體的標題化合物(12 mg,4%產率):mp 90°C - 92°C;1
H NMR (400 MHz, DMSO-d 6
) δ 7.67 (s, 1H), 7.38 (d,J
= 6.8 Hz, 1H), 7.27-7.20 (m, 3H), 6.62 (s, 1H), 5.59-5.51 (m, 1H), 5.28 (s, 2H), 3.73 (s, 3H), 2.54 (d,J
= 4.8 Hz, 3H), 2.43 (s, 3H), 2.35 (s, 3H), 2.01 (s, 3H); ESIMSm/z
341 ([M+H]+
)。實例 11 : (E)-4-((( 乙基 ( 甲基 ) 胺基 ) 亞甲基 ) 胺基 )-2,5- 二甲基苯甲酸的製備。
在25 mL小瓶中,製備(E
)-4-(((乙基(甲基)胺基)亞甲基)胺基)-2,5-二甲基苯甲酸酯(1.20 g,4.83 mmol)在甲醇(9.66mL)中的溶液。然後添加NaOH水溶液(1M,4.83 mL,4.83 mmol),並將反應加熱至60°C並攪拌過夜。18 h後,將反應冷卻至室溫並濃縮至乾燥。將反應重新溶解於水(20 mL)中,並用Et2
O(20 mL)萃取。用1N HCl酸化水層,並用DCM(3 x 20 mL)萃取。在有機層中未觀察到物質,並且將水層濃縮以提供粗物質。將物質藉由快速柱層析(C18反相,在水中的10%à90%乙腈)純化以提供呈黃褐色固體的標題化合物(443 mg,1.89 mmol,39%產率):1
H NMR (400 MHz, DMSO-d 6
) δ 12.94 (s, 1H), 11.20 (s, 1H), 8.40 (d,J
= 56.6 Hz, 1H), 7.76 (s, 1H), 7.31 (d,J
= 10.6 Hz, 1H), 3.70 (dq,J
= 46.9, 7.1 Hz, 2H), 3.30 (d,J
= 2.6 Hz, 3H), 2.50 (dd,J
= 3.7, 1.9 Hz, 2H), 2.36 (d,J
= 2.5 Hz, 3H), 1.26 (dt,J
= 9.7, 7.1 Hz, 3H); mp > 250°C;ESIMSm/z
335 [(M+H)+
]。實例 12 : 3-( 三氟甲基 ) 苄基 (Z)-4-((( 乙基 ( 甲基 ) 胺基 )( 甲硫基 ) 亞甲基 ) 胺基 )-2,5- 二甲基苯甲酸酯的製備。
製備3-(三氟甲基)苄基4-(3-乙基-3-甲基硫脲基)-2,5-二甲基苯甲酸酯(0.050g,0.118mmol)在丙酮(1.18 mL)中的溶液。向該溶液中添加K2
CO3
(0.033 g,0.24 mmol)和碘甲烷(10 μL,0.16 mmol)。然後將混合物在環境溫度下攪拌18 h。然後將反應用乙酸乙酯(50 mL)稀釋,通過矽藻土過濾並濃縮至油狀物。將粗物質藉由快速柱層析法(矽膠(SiO2
),在己烷中的0à70%乙酸乙酯溶液)純化以提供呈澄清油狀物的標題化合物(49 mg,0.11 mmol,95%產率):1
H NMR (500 MHz, CDCl3
) δ 7.82-7.78 (m, 1H), 7.71 (d,J
= 1.8 Hz, 1H), 7.64 (d,J
= 7.6 Hz, 1H), 7.59 (d,J
= 7.8 Hz, 1H), 7.51 (t,J
= 7.7 Hz, 1H), 6.68 (s, 1H), 5.35 (s, 2H), 3.57 (q,J
= 7.1 Hz, 2H), 3.08 (s, 3H), 2.54 (s, 3H), 2.14 (s, 3H), 1.94 (s, 3H), 1.20 (t,J
= 7.0 Hz, 3H);19
F NMR (471 MHz, CDCl3
) δ - 62.60; ESIMSm/z
439 [(M+H)+
]。實例 13 : 3-( 三氟甲基 ) 苄基 4-((( 乙基 ( 甲基 ) 胺基 ) 亞甲基 ) 胺基 )-2,3- 二甲基苯甲酸酯鹽酸鹽的製備。
將3-(三氟甲基)苄基 (E
)-4-(((乙基(甲基)胺基)亞甲基)胺基)-2,3-二甲基苯甲酸酯溶解在庚烷中,並轉移至分液漏斗中。添加2N HCl,並分離得到的層。棄去庚烷層,並將水層用乙酸乙酯萃取。濃縮有機層,以提供呈淺棕色固體的3-(三氟甲基)苄基4-(((乙基(甲基)胺基)亞甲基)胺基)-2,3-二甲基苯甲酸酯鹽酸鹽(237 mg,0.553 mmol)和約2 : 1的E
:Z
異構物的混合物:1
H NMR (500 MHz, CDCl3
) δ 12.64-12.53 (m, 1H), 7.95-7.86 (m, 1H), 7.70-7.65 (m, 1H), 7.65-7.57 (m, 3H), 7.56-7.49 (m, 1H), 7.28-7.22 (m, 0.6H), 5.37 (s, 2H), 4.00 (q,J
= 7.2 Hz, 0.6H), 3.64 (q,J
= 7.2 Hz, 1.4H), 3.50 (s, 2H), 3.33 (s, 1H), 2.44 (s, 3H), 2.38 (s, 3H), 1.36-1.28 (m, 3H);19
F NMR (471 MHz, CDCl3
) δ - 62.64; 對於C21
H23
F3
N2
O2
計算的HRMS-ESI (m/z
) [M+H]+
為393.1784,實測值為393.1793;m.p.172°C -176°C。通用生物學實驗詳述 實例 A :殺真菌活性的評估:小麥斑葉枯病( Zymoseptoria tritici ;拜耳代碼 SEPTTR ):
將工業級的物質溶解在丙酮中,然後將其與九體積的含有110 ppm Triton X-100的水(H2
O)混合。使用自動噴箱噴霧器將殺真菌劑溶液施用到小麥幼苗上,以使其徑流。在進一步處理之前,將所有噴霧的植物風乾。除非另有說明,否則使用前述方法評估所有殺真菌劑相對於所有目標疾病的活性。
在溫室中小麥植物(「Yuma」品種)從在無土的盆栽混合物中的種子生長,直到第一片葉子完全出來,每盆7-10株幼苗。在殺真菌劑處理前3天(3天治療劑;3DC)或在殺真菌劑處理後1天(1天保護劑;1DP)對該等植物接種Zymoseptoria tritici
的孢子水懸液。接種後,將植物在100%相對濕度下保持三天,以使孢子萌發並感染葉片。然後將植物轉移到溫室中以使疾病發展。當未處理的植物的第一片葉子上完全表現出病害症狀時,以病害嚴重程度為0%至100%的等級評估感染水平。使用處理的植物的疾病嚴重程度相對於未處理的植物的疾病嚴重程度的比率來計算疾病控制百分數。實例 B :殺真菌活性的評估:小麥褐銹病(小麥葉鏽菌;同義詞:小麥葉鏽菌( Puccinia recondita f. sp. tritici );拜耳代碼 PUCCRT ):
在溫室中小麥植物(「Yuma」品種)從在無土的盆栽混合物中的種子生長,直到第一片葉子完全出來,每盆7-10株幼苗。在殺真菌劑處理後,將該等植物用小麥葉鏽菌的孢子水懸液接種。接種後,將植物在暗室中在100%相對濕度下保持過夜,以使孢子萌發並感染葉片。然後將植物轉移到溫室中以使疾病發展。殺真菌劑的配製、施用和疾病評估遵循實例A中所述之程序。實例 C :殺真菌活性的評估:亞洲大豆鏽菌病(豆薯層鏽菌( Phakopsora pachyrhizi );拜耳代碼 PHAKPA ):
將工業級的物質溶解在丙酮中,然後將其與九體積的含有0.011% Tween 20的H2
O混合。使用自動噴箱噴霧器將殺真菌劑溶液施用到大豆幼苗上,以使其徑流。在進一步處理之前,將所有噴霧的植物風乾。
在無土的盆栽混合物中,栽培大豆植物(「Williams 82」品種),每盆一株植物。使用十天大的幼苗進行測試。如實例A中該接種植物。將植物在暗室中在100%相對濕度下孵育24小時,然後轉移至生長室以使疾病發展。如實例A中所述進行殺真菌劑的配製和施用。當疾病症狀完全表現後,以0至100百分比的等級評估噴霧葉片的疾病嚴重程度。使用處理的植物的疾病嚴重程度相對於未處理的植物的疾病嚴重程度的比率來計算疾病控制百分數。實例 D :殺真菌活性的評估:大麥斑點病(大麥雲紋病菌( Rhynchosporium secalis ));拜耳代碼 RHYNSE ):
在溫室中大麥植物(「Harrington」品種)從在無土的盆栽混合物中的種子生長,直到第一片葉子完全出來,每盆7-10株幼苗。在殺真菌劑處理後,將該等植物用大麥雲紋病菌的孢子水懸液接種。接種後,將植物在暗室中在100%相對濕度下保持兩天,以使孢子萌發並感染葉片。然後將植物轉移到溫室中以使疾病發展。如實例A中所述進行殺真菌劑的配製和施用。如實例A中所述進行疾病評估。實例 E :殺真菌活性的評估:大麥斑點病(禾旋孢腔菌( Cochliobolus sativus ));拜耳代碼 COCHSA ):
在無土的盆栽混合物中,繁殖大麥幼苗(Harrington品種),每個盆8到12株植物,並當第一片葉子完全出來時用於測試。用殺真菌劑處理後24小時,將測試植物用禾旋孢腔菌的孢子懸浮液接種。接種後,將植物在100%相對濕度下保持兩天,以使孢子萌發並感染葉片。然後將植物轉移到溫室中以使疾病發展。殺真菌劑的配製、施用和疾病評估遵循實例A中所述之程序。
[表 1
]. 化合物的結構、製備方法和外觀
[表 2
]. 分析表徵數據
[表 3
]. 生物測試等級量表
[表 4
]. 生物活性 - 在 200 ppm 施用時 COCHSA 、 PHAKPA 、 PUCCRT 、 RHYNSE 、和 SEPTTR 疾病控制
*Cmpd.No. - 化合物編號
*COCHSA - 大麥斑點病(禾旋孢腔菌(Cochliobolus sativus
))
*PHAKPA - 亞洲大豆鏽菌病(豆薯層鏽菌(Phakopsora pachyrhizi
))
*PUCCRT - 小麥褐銹病(小麥葉鏽菌)
*RHYNSE - 大麥斑點病(大麥雲紋病菌(Rhynochosporium commune
))
*SEPTTR - 小麥斑葉枯病(Zymoseptoria tritici
)
*1DP - 1天保護劑
*3DC - 3天治療劑
*ppm - 百萬分率
化合物編號 | 結構 | 根據如下製備 | 外觀 |
1 | 實例9A;實例10A. | 橙色液體 | |
2 | 實例9A;實例10A;實例11. | 黃褐色固體 | |
3 | 實例9A;實例10A. | 澄清無色油狀物 | |
4 | 實例9A;實例10A. | 澄清無色油狀物 | |
5 | 實例9A;實例10A. | 黃色固體 | |
6 | 實例9A;實例10A. | 黃色油狀物 | |
7 | 實例9A;實例10A. | 白色固體 | |
8 | 實例9A;實例10A. | 澄清無色油狀物 | |
9 | 實例9A;實例10A. | 白色固體 | |
10 | 實例9A;實例10A. | 黃色固體 | |
11 | 實例9A;實例10A. | 橙色固體 | |
12 | 實例9A;實例10A. | 黃色油狀物 | |
13 | 實例9A;實例10A. | 黃色油狀物 | |
14 | 實例9A;實例10A. | 黃色油狀物 | |
15 | 實例9A;實例10A. | 黃色油狀物 | |
16 | 實例9A;實例10A. | 橙色油狀物 | |
17 | 實例9A;實例10A. | 橙色油狀物 | |
18 | 實例9A;實例10A. | 橙色油狀物 | |
19 | 實例9A;實例10A. | 橙色油狀物 | |
20 | 實例9A;實例10A. | 橙色油狀物 | |
21 | 實例9A;實例10A. | 橙色油狀物 | |
22 | 實例9A;實例10A. | 橙色油狀物 | |
23 | 實例9A;實例10A. | 深色油狀物 | |
24 | 實例9A;實例10A. | 橙色油狀物 | |
25 | 實例9B;實例10A. | 黃色油狀物 | |
26 | 實例9A;實例10A. | 黃色油狀物 | |
27 | 實例9A;實例10A. | 黃色油狀物 | |
28 | 實例9A;實例10A. | 黃色油狀物 | |
29 | 實例9A;實例10A. | 黃色油狀物 | |
30 | 實例9B;實例10A. | 橙色油狀物 | |
31 | 實例9A;實例10A. | 白色半固體 | |
32 | 實例9A;實例10A. | 黃色油狀物 | |
33 | 實例9A;實例10A. | 黃色油狀物 | |
34 | 實例9A;實例10A. | 白色固體 | |
35 | 實例9A;實例10A. | 黃色油狀物 | |
36 | 實例9A;實例10A. | 黃色油狀物 | |
37 | 實例9A;實例10A. | 棕色油狀物 | |
38 | 實例9A;實例10A. | 棕色油狀物 | |
39 | 實例9A;實例10A. | 棕色油狀物 | |
40 | 實例9A;實例10A. | 棕色油狀物 | |
41 | 實例9A;實例10A. | 棕色油狀物 | |
42 | 實例9A;實例10A. | 棕色油狀物 | |
43 | 實例9A;實例10A. | 棕色油狀物 | |
44 | 實例9B;實例10A. | 棕色油狀物 | |
45 | 實例9B;實例10A. | 棕色油狀物 | |
46 | 實例9A;實例10A. | 棕色油狀物 | |
47 | 實例9A;實例10A. | 棕色油狀物 | |
48 | 實例9A;實例10A. | 棕色油狀物 | |
49 | 實例9A;實例10A. | 棕色油狀物 | |
50 | 實例9A;實例10A. | 棕色油狀物 | |
51 | 實例9A;實例10A. | 棕色油狀物 | |
52 | 實例9A;實例10A. | 棕色油狀物 | |
53 | 實例9A;實例10A. | 澄清無色油狀物 | |
54 | 實例9A;實例10A. | 澄清無色油狀物 | |
55 | 實例9A;實例10A. | 澄清無色油狀物 | |
56 | 實例9A;實例10A. | 澄清無色油狀物 | |
57 | 實例9A;實例10A. | 澄清無色油狀物 | |
58 | 實例9C;實例10A. | 棕色油狀物 | |
59 | 實例9C;實例10A. | 棕色油狀物 | |
60 | 實例9B;實例10B. | 深棕色半固體 | |
61 | 實例9B;實例10B. | 棕色油狀物 | |
62 | 實例9B;實例10B. | 橙色油狀物 | |
63 | 實例9B;實例10B. | 黃色油狀物 | |
64 | 實例9B;實例10B. | 橙色油狀物 | |
65 | 實例9B;實例10B. | 黃色油狀物 | |
66 | 實例9B;實例10B. | 橙色油狀物 | |
67 | 實例9B;實例10B. | 灰白色半固體 | |
68 | 實例9B;實例10B. | 棕色油狀物 | |
69 | 實例9B;實例10B. | 橙色油狀物 | |
70 | 實例9B;實例10B. | 黃色油狀物 | |
71 | 實例9B;實例10B. | 橙色油狀物 | |
72 | 實例9B;實例10B. | 黃色油狀物 | |
73 | 實例9B;實例10D. | 灰白色半固體 | |
74 | 實例9B;實例10D. | 白色半固體 | |
75 | 實例9B;實例10D. | 白色半固體 | |
76 | 實例9B;實例10D. | 淡玫瑰色半固體 | |
77 | 實例9B;實例10D. | 白色半固體 | |
78 | 實例9B;實例10D. | 白色半固體 | |
79 | 實例9B;實例10D. | 白色半固體 | |
80 | 實例9B;實例10D. | 白色半固體 | |
81 | 實例9B;實例10D. | 澄清無色油狀物 | |
82 | 實例9B;實例10D. | 白色半固體 | |
83 | 實例9B;實例10D. | 白色半固體 | |
84 | 實例9B;實例10D. | 白色半固體 | |
85 | 實例9B;實例10D. | 淡黃色油狀物 | |
86 | 實例9B;實例10D. | 白色半固體 | |
87 | 實例9A;實例10A. | 橙色油狀物 | |
88 | 實例9A;實例10A. | 黃色油狀物 | |
89 | 實例9A;實例10A. | 黃色油狀物 | |
90 | 實例9A;實例10A. | 橙色油狀物 | |
91 | 實例8B;實例9C;實例10A. | 橙色油狀物 | |
92 | 實例8B;實例9C;實例10A. | 橙色油狀物 | |
93 | 實例9A;實例10A. | 棕色油狀物 | |
94 | 實例9A;實例10A. | 棕色油狀物 | |
95 | 實例9A;實例10A. | 黃色油狀物 | |
96 | 實例9A;實例10A. | 灰白色半固體 | |
97 | 實例9B;實例10A. | 黃色油狀物 | |
98 | 實例8A;實例9C;實例10A. | 黃色油狀物 | |
99 | 實例8A;實例9C;實例10A. | 黃色油狀物 | |
100 | 實例8A;實例9C;實例10A. | 黃色油狀物 | |
101 | 實例8A;實例9C;實例10A. | 黃色油狀物 | |
102 | 實例8A;實例9C;實例10A. | 黃色油狀物 | |
103 | 實例8A;實例9C;實例10A. | 黃色油狀物 | |
104 | 實例9B;實例10C. | 黃色油狀物 | |
105 | 實例9B;實例10C. | 淡黃色黏性液體 | |
106 | 實例9B;實例10C. | 灰白色固體 | |
107 | 實例9B;實例10C. | 淡黃色膠狀液體 | |
108 | 實例9B;實例10E. | 灰白色固體 | |
109 | 實例9A;實例10A. | 淡黃色半固體 | |
110 | 實例9A;實例10A. | 棕色膠狀液體 | |
111 | 實例9A;實例10A. | 淡棕色液體 | |
112 | 實例9B;實例10D. | 白色半固體 | |
113 | 實例9B;實例10D. | 白色半固體 | |
114 | 實例9B;實例10D. | 白色半固體 | |
115 | 實例9B;實例10D. | 白色半固體 | |
116 | 實例9B;實例10D. | 白色半固體 | |
117 | 實例9B;實例10D. | 白色半固體 | |
118 | 實例9B;實例10D. | 白色半固體 | |
119 | 實例9B;實例10D. | 白色半固體 | |
120 | 實例9B;實例10D. | 白色半固體 | |
121 | 實例9B;實例10D. | 白色半固體 | |
122 | 實例9B;實例10B. | 淡黃色油狀物 | |
123 | 實例9B;實例10B. | 淡黃色油狀物 | |
124 | 實例9B;實例10B. | 淡黃色油狀物 | |
125 | 實例9B;實例10B. | 淡黃色油狀物 | |
126 | 實例9B;實例10B. | 澄清無色油狀物 | |
127 | 實例9B;實例10B. | 澄清無色油狀物 | |
128 | 實例9B;實例10B. | 淡黃色油狀物 | |
129 | 實例9B;實例10B. | 淡黃色油狀物 | |
130 | 實例8A;實例9C;實例10A. | 橙色油狀物 | |
131 | 實例8A;實例9C;實例10A. | 橙色油狀物 | |
132 | 實例8A;實例9C;實例10A. | 橙色油狀物 | |
133 | 實例8A;實例9C;實例10A. | 橙色油狀物 | |
134 | 實例8A;實例9C;實例10A. | 橙色油狀物 | |
135 | 實例8A;實例9C;實例10A. | 橙色油狀物 | |
136 | 實例8A;實例9C;實例10A. | 橙色油狀物 | |
137 | 實例8A;實例9C;實例10A. | 橙色油狀物 | |
138 | 實例8A;實例9C;實例10A. | 橙色油狀物 | |
139 | 實例8A;實例9C;實例10A. | 橙色油狀物 | |
140 | 實例8A;實例9C;實例10A. | 橙色油狀物 | |
141 | 實例8A;實例9C;實例10A. | 橙色油狀物 | |
142 | 實例8A;實例9C;實例10A. | 橙色油狀物 | |
143 | 實例8A;實例9C;實例10A. | 橙色油狀物 | |
144 | 實例9A;實例10A. | 淡黃色油狀物 | |
145 | 實例9A;實例10A. | 灰白色固體 | |
146 | 實例9A;實例10A. | 蠟質淡黃色半固體 | |
147 | 實例9A;實例10A. | 淡黃色油狀物 | |
148 | 實例9A;實例10A. | 淡黃色油狀物 | |
149 | 實例9A;實例10A. | 棕色油狀物 | |
150 | 實例9A;實例10A. | 棕色固體 | |
151 | 實例9A;實例10A. | 棕色固體 | |
152 | 實例9A;實例10A. | 棕色油狀物 | |
153 | 實例9A;實例10A. | 棕色油狀物 | |
154 | 實例9A;實例10A. | 棕色固體 | |
155 | 實例9A;實例10A. | 黃褐色固體 | |
156 | 實例9A;實例10A. | 淺棕色固體 | |
157 | 實例9A;實例10A. | 棕色油狀物 | |
158 | 實例9A;實例10A. | 淺棕色半固體 | |
159 | 實例9A;實例10A. | 淺棕色油狀物 | |
160 | 實例9A;實例10A. | 黃褐色半固體 | |
161 | 實例9A;實例10A. | 黃褐色固體 | |
162 | 實例9A;實例10A. | 灰白色固體 | |
163 | 實例9C;實例10A. | 棕色油狀物 | |
164 | 實例9A;實例10A. | 淺棕色油狀物 | |
165 | 實例9A;實例10A. | 淺棕色油狀物 | |
166 | 實例9A;實例10A. | 棕色油狀物 | |
167 | 實例9B;實例10A. | 棕色油狀物 | |
168 | 實例9A;實例10A. | 澄清油狀物 | |
169 | 實例9A;實例10A. | 棕色油狀物 | |
170 | 實例9A;實例10A. | 棕色油狀物 | |
171 | 實例9A;實例10A. | 灰白色固體 | |
172 | 實例9A;實例10A. | 棕色油狀物 | |
173 | 實例9A;實例10A. | 棕色油狀物 | |
174 | 實例9A;實例10A. | 棕色油狀物 | |
175 | 實例9A;實例10C. | 黃色油狀物 | |
176 | 實例9A;實例10A. | 淡黃色固體 | |
177 | 實例9A;實例10A. | 淺棕色固體 | |
178 | 實例9A;實例10A. | 淡黃色油狀物 | |
179 | 實例9A;實例10A. | 黃色油狀物 | |
180 | 實例9A;實例10A. | 黃色固體 | |
181 | 實例9A;實例10A. | 黃色油狀物 | |
182 | 實例9A;實例10A. | 黃色油狀物 | |
183 | 實例9B;實例10A. | 黃色油狀物 | |
184 | 實例9A;實例10A. | 黃色油狀物 | |
185 | 實例9A;實例10A. | 黃色油狀物 | |
186 | 實例9A;實例10A. | 黃色固體 | |
187 | 實例9A;實例10A. | 黃色固體 | |
188 | 實例9A;實例10A. | 黃色固體 | |
189 | 實例9A;實例10A. | 淺黃色固體 | |
190 | 實例9A;實例10A. | 黃色固體 | |
191 | 實例9A;實例10A. | 淺黃色固體 | |
192 | 實例9A;實例10A. | 深黃棕色油狀物 | |
193 | 實例9A;實例10A. | 深黃色固體 | |
194 | 實例9A;實例10A. | 深黃色固體 | |
195 | 實例9A;實例10A. | 深黃色油狀物 | |
196 | 實例9A;實例10A. | 黃色油狀物 | |
197 | 實例9A;實例10A. | 深棕色油狀物 | |
198 | 實例9A;實例10A. | 深棕色油狀物 | |
199 | 實例9B;實例10D. | 深黃色油狀物 | |
200 | 實例9A;實例10D. | 黃色固體 | |
201 | 實例9A;實例10D. | 黃色固體 | |
202 | 實例9A;實例10D. | 深黃色油狀物 | |
203 | 實例9A;實例10D. | 黃色固體 | |
204 | 實例9A;實例10A. | 淺棕色油狀物 | |
205 | 實例9A;實例10A. | 淡黃色油狀物 | |
206 | 實例9A;實例10A. | 淺橙色固體 | |
207 | 實例9A;實例10A. | 淡黃色油狀物 | |
208 | 實例9A;實例10A. | 棕色油狀物 | |
209 | 實例9A;實例10A. | 棕色油狀物 | |
210 | 實例9A;實例10A. | 淡棕色油狀物 | |
211 | 實例9A;實例10A. | 淡黃色油狀物 | |
212 | 實例9A;實例10A. | 淡黃色油狀物 | |
213 | 實例9A;實例10A. | 淡黃色油狀物 | |
214 | 實例9A;實例10A. | 澄清無色油狀物 | |
215 | 實例9A;實例10A. | 白色半固體 | |
216 | 實例9A;實例10A. | 澄清無色油狀物 | |
217 | 實例9A;實例10A. | 淡黃色油狀物 | |
218 | 實例9B;實例10C. | 黃色油狀物 | |
219 | 實例9B;實例10C. | 淡黃色油狀物 | |
220 | 實例9A;實例10A. | 灰白色固體 | |
221 | 實例9A;實例10A. | 淡黃色油狀物 | |
222 | 實例9B;實例10B. | 黃色油狀物 | |
223 | 實例9B;實例10B. | 澄清油狀物 | |
224 | 實例9B;實例10B. | 澄清油狀物 | |
225 | 實例9B;實例10B. | 澄清油狀物 | |
226 | 實例9B;實例10B. | 淺黃色油狀物 | |
227 | 實例9B;實例10B. | 澄清油狀物 | |
228 | 實例9B;實例10B. | 淺黃色油狀物 | |
229 | 實例9B;實例10B. | 淺黃色油狀物 | |
230 | 實例9C;實例10A. | 黃色油狀物 | |
231 | 實例9C;實例10A. | 黃色油狀物 | |
232 | 實例9C;實例10A. | 黃色油狀物 | |
233 | 實例8A;實例9C;實例10A. | 黃色油狀物 | |
234 | 實例8A;實例9C;實例10A. | 黃色油狀物 | |
235 | 實例8A;實例9C;實例10A. | 黃色油狀物 | |
236 | 實例8A;實例9C;實例10A. | 黃色油狀物 | |
237 | 實例8A;實例9C;實例10A. | 黃色油狀物 | |
238 | 實例9B;實例10D. | 黃色固體 | |
239 | 實例9B;實例10D. | 黃色固體 | |
240 | 實例9B;實例10D. | 黃色固體 | |
241 | 實例9B;實例10D. | 灰白色固體 | |
242 | 實例9B;實例10D. | 黃色固體 | |
243 | 實例9B;實例10D. | 白色固體 | |
244 | 實例9B;實例10D. | 灰白色固體 | |
245 | 實例9B;實例10D. | 灰白色固體 | |
246 | 實例9A;實例10A. | 深黃色油狀物 | |
247 | 實例9A;實例10A. | 厚黃色油狀物 | |
248 | 實例9A;實例10A. | 棕色油狀物 | |
249 | 實例9A;實例10A. | 黃色油狀物 | |
250 | 實例9A;實例10A. | 深黃色固體 | |
251 | 實例9A;實例10A. | 黃色油狀物 | |
252 | 實例9A;實例10A. | 淺黃色固體 | |
253 | 實例9A;實例10A. | 黃色油狀物 | |
254 | 實例9A;實例10A. | 灰白色固體 | |
255 | 實例9A;實例10A. | 灰白色固體 | |
256 | 實例9A;實例10A. | 澄清油狀物 | |
257 | 實例9A;實例10A. | 淺黃色油狀物 | |
258 | 實例9A;實例10A. | 淺黃色油狀物 | |
259 | 實例9B;實例10C. | 淺黃色油狀物 | |
260 | 實例9B;實例10C. | 白色固體 | |
261 | 實例9B;實例10C. | 澄清油狀物 | |
262 | 實例9B;實例10C. | 黃色油狀物 | |
263 | 實例9B;實例10C. | 棕色油狀物 | |
264 | 實例9B;實例10C. | 淡黃色油狀物 | |
265 | 實例9B;實例10C. | 淡黃色油狀物 | |
266 | 實例9A;實例10A. | 黃色油狀物 | |
267 | 實例9A;實例10A. | 灰白色固體 | |
268 | 實例9A;實例10A. | 黃色油狀物 | |
269 | 實例9A;實例10A. | 黃色油狀物 | |
270 | 實例9A;實例10A. | 黃色油狀物 | |
271 | 實例9A;實例10A. | 黃色油狀物 | |
272 | 實例9A;實例10A. | 黃色油狀物 | |
273 | 實例9A;實例10A. | 黃色油狀物 | |
274 | 實例9A;實例10A. | 深黃色油狀物 | |
275 | 實例9A;實例10A. | 黃色油狀物 | |
276 | 實例9A;實例10A. | 棕色油狀物 | |
277 | 實例9A;實例10A. | 黃色油狀物 | |
278 | 實例9A;實例10A. | 黃色油狀物 | |
279 | 實例9A;實例10A. | 灰白色固體 | |
280 | 實例9A;實例10A. | 黃色油狀物 | |
281 | 實例9B;實例10D. | 淡黃色油狀物 | |
282 | 實例9B;實例10D. | 淡黃色油狀物 | |
283 | 實例9B;實例10D. | 淡黃色油狀物 | |
284 | 實例9B;實例10D. | 淡黃色油狀物 | |
285 | 實例1B;實例3B;實例9A;實例10A. | 黏性蠟狀物 | |
286 | 實例1B;實例3B;實例9A;實例10A. | 白色固體 | |
287 | 實例1B;實例3B;實例9A;實例10A. | 黃色固體 | |
288 | 實例1B;實例3B;實例9A;實例10A. | 白色固體 | |
289 | 實例1B;實例3B;實例9A;實例10A. | 白色固體 | |
290 | 實例1B;實例3B;實例9A;實例10A. | 白色固體 | |
291 | 實例1B;實例3B;實例9A;實例10A. | 白色固體 | |
292 | 實例1B;實例3B;實例9A;實例10A. | 黏性蠟狀物 | |
293 | 實例6A;實例7A;實例9A;實例10A. | 黃色油狀物 | |
294 | 實例6A;實例7A;實例9A;實例10A. | 黃色油狀物 | |
295 | 實例6A;實例7A;實例9A;實例10A. | 淺黃色固體 | |
296 | 實例6A;實例7A;實例9A;實例10A. | 淺黃色油狀物 | |
297 | 實例6A;實例7A;實例9A;實例10D. | 白色固體 | |
298 | 實例6A;實例7A;實例9A;實例10D. | 白色固體 | |
299 | 實例6A;實例7A;實例9A;實例10A. | 棕色油狀物 | |
300 | 實例6A;實例7A;實例9A;實例10A. | 黃色油狀物 | |
301 | 實例9B;實例10A. | 深橙色油性固體 | |
302 | 實例9A;實例10A. | 深橙色油性固體 | |
303 | 實例9A;實例10A. | 深橙色油狀物 | |
304 | 實例6A;實例7A;實例9A;實例10A. | 黃色油狀物 | |
305 | 實例9A;實例10A. | 黃色油狀物 | |
306 | 實例9A;實例10A. | 白色固體 | |
307 | 實例9A;實例10A. | 淡黃色油狀物 | |
308 | 實例9A;實例10A. | 白色固體 | |
309 | 實例9A;實例10A. | 澄清油狀物 | |
310 | 實例9A;實例10A. | 白色固體 | |
311 | 實例9A;實例10A. | 黃色油狀物 | |
312 | 實例9A;實例10A. | 黃色油狀物 | |
313 | 實例9A;實例10A. | 白色固體 | |
314 | 實例9A;實例10A. | 澄清油狀物 | |
315 | 實例6C;實例7B;實例9A;實例10A. | 黃色油狀物 | |
316 | 實例6C;實例7B;實例9A;實例10A. | 黃色油狀物 | |
317 | 實例6C;實例7B;實例9A;實例10A. | 黃色油狀物 | |
318 | 實例9A;實例10A. | 黃色油狀物 | |
319 | 實例6C;實例7B;實例9A;實例10D. | 深黃色油狀物 | |
320 | 實例9B;實例10D. | 淺黃色固體 | |
321 | 實例9A;實例10D. | 黃色油狀物 | |
322 | 實例9A;實例10D. | 黃色油狀物 | |
323 | 實例6C;實例7B;實例9A;實例10C. | 澄清鐵銹棕色油狀物 | |
324 | 實例9A;實例10A. | 白色固體 | |
325 | 實例9A;實例10A. | 淡黃色固體 | |
326 | 實例1B;實例2B;實例3B;實例9A;實例10A. | 澄清無色油狀物 | |
327 | 實例1B;實例2B;實例3B;實例9A;實例10A. | 澄清無色油狀物 | |
328 | 實例1B;實例2B;實例3B;實例9A;實例10A. | 澄清無色油狀物 | |
329 | 實例1B;實例2B;實例3B;實例9A;實例10A. | 澄清無色油狀物 | |
330 | 實例1B;實例2B;實例3B;實例9A;實例10A. | 澄清無色油狀物 | |
331 | 實例1B;實例2B;實例3B;實例9A;實例10A. | 澄清無色油狀物 | |
332 | 實例9B;實例10D. | 灰白色固體 | |
333 | 實例6A;實例7A;實例9A;實例10D. | 白色固體 | |
334 | 實例6A;實例7A;實例9A;實例10A. | 橙色液體 | |
335 | 實例6A;實例7A;實例9A;實例10A. | 白色固體 | |
336 | 實例6A;實例7A;實例9A;實例10A. | 淡棕色固體 | |
337 | 實例6A;實例7A;實例9A;實例10A. | 淡棕色膠狀液體 | |
338 | 實例6A;實例7A;實例9A;實例10A. | 棕色固體 | |
339 | 實例6A;實例7A;實例9A;實例10A. | 灰白色固體 | |
340 | 實例6A;實例7A;實例9A;實例10A. | 灰白色固體 | |
341 | 實例6A;實例7A;實例9A;實例10A. | 灰白色固體 | |
342 | 實例6A;實例7A;實例9A;實例10A. | 灰白色固體 | |
343 | 實例6A;實例7A;實例9A;實例10A. | 黃色液體 | |
344 | 實例6A;實例7A;實例9A;實例10A. | 灰白色固體 | |
345 | 實例6A;實例7A;實例9A;實例10A. | 黃色液體 | |
346 | 實例6A;實例7A;實例9A;實例10A. | 淡微紅色膠狀液體 | |
347 | 實例6A;實例7A;實例9A;實例10A. | 棕色固體 | |
348 | 實例6A;實例7A;實例9A;實例10A. | 淡黃色液體 | |
349 | 實例6A;實例7A;實例9A;實例10A. | 棕色膠狀液體 | |
350 | 實例6A;實例7A;實例9A;實例10A. | 棕色液體 | |
351 | 實例6A;實例7A;實例9A;實例10A. | 淡棕色固體 | |
352 | 實例6A;實例7A;實例9C;實例10A. | 橙色膠狀液體 | |
353 | 實例6A;實例7A;實例9A;實例10A. | 淡橙色液體 | |
354 | 實例6A;實例7A;實例9A;實例10A. | 淡黃色固體 | |
355 | 實例6A;實例7A;實例9A;實例10A. | 灰白色黏性固體 | |
356 | 實例6A;實例7A;實例9A;實例10A. | 淡棕色液體 | |
357 | 實例6A;實例7A;實例9A;實例10A. | 灰白色固體 | |
358 | 實例9A;實例10A. | 淺黃色油狀物 | |
359 | 實例9A;實例10A. | 淺黃色油狀物 | |
360 | 實例9A;實例10A. | 淺黃色半固體 | |
361 | 實例9A;實例10A. | 淺黃色油狀物 | |
362 | 實例9A;實例10D. | 灰白色固體 | |
363 | 實例9A;實例10D. | 灰白色固體 | |
364 | 實例9A;實例10D. | 灰白色固體 | |
365 | 實例9A;實例10D. | 灰白色固體 | |
366 | 實例9A;實例10D. | 白色固體 | |
367 | 實例9A;實例10D. | 白色固體 | |
368 | 實例9A;實例10D. | 灰白色固體 | |
369 | 實例9A;實例10A. | 黃色油狀物 | |
370 | 實例9A;實例10A. | 黃色油狀物 | |
371 | 實例9A;實例10A. | 黃色油狀物 | |
372 | 實例9A;實例10A. | 黃色油狀物 | |
373 | 實例9A;實例10A. | 黃色油狀物 | |
374 | 實例9A;實例10A. | 黃色油狀物 | |
375 | 實例9A;實例10A. | 黃色油狀物 | |
376 | 實例9A;實例10A. | 黃色半固體 | |
377 | 實例9A;實例10A. | 黃色油狀物 | |
378 | 實例9A;實例10A. | 灰白色蠟質固體 | |
379 | 實例9A;實例10A. | 黃色油狀物 | |
380 | 實例9A;實例10A. | 黃色油狀物 | |
381 | 實例9A;實例10A. | 橙色油狀物 | |
382 | 實例9A;實例10A. | 橙色油狀物 | |
383 | 實例9A;實例10A. | 黃色蠟質固體 | |
384 | 實例4;實例5;實例6A;實例7A;實例9A;實例10A. | 淡棕色膠狀液體 | |
385 | 實例4;實例5;實例6A;實例7A;實例9A;實例10A. | 棕色液體 | |
386 | 實例4;實例5;實例6A;實例7A;實例9A;實例10A. | 淡棕色膠狀固體 | |
387 | 實例4;實例5;實例6A;實例7A;實例9A;實例10A. | 淡棕色固體 | |
388 | 實例4;實例5;實例6A;實例7A;實例9A;實例10A. | 棕色液體 | |
389 | 實例4;實例5;實例6A;實例7A;實例9A;實例10A. | 淡棕色黏性固體 | |
390 | 實例4;實例5;實例6A;實例7A;實例9A;實例10A. | 灰白色固體 | |
391 | 實例4;實例5;實例6A;實例7A;實例9A;實例10A. | 淡棕色固體 | |
392 | 實例4;實例5;實例6A;實例7A;實例9A;實例10A. | 淡黃色固體 | |
393 | 實例4;實例5;實例6A;實例7A;實例9A;實例10A. | 淡棕色膠狀液體 | |
394 | 實例4;實例5;實例6A;實例7A;實例9A;實例10A. | 灰白色固體 | |
395 | 實例4;實例5;實例6A;實例7A;實例9A;實例10A. | 淡棕色固體 | |
396 | 實例4;實例5;實例6A;實例7A;實例9A;實例10A. | 淡黃色固體 | |
397 | 實例4;實例5;實例6A;實例7A;實例9C;實例10A. | 棕色膠狀液體 | |
398 | 實例4;實例5;實例6A;實例7A;實例9A;實例10A. | 淡棕色固體 | |
399 | 實例4;實例5;實例6A;實例7A;實例9A;實例10A. | 灰色(ash color)固體 | |
400 | 實例4;實例5;實例6A;實例7A;實例9A;實例10A. | 灰白色固體 | |
401 | 實例4;實例5;實例6A;實例7A;實例9A;實例10A. | 灰白色固體 | |
402 | 實例4;實例5;實例6A;實例7A;實例9A;實例10A. | 灰白色固體 | |
403 | 實例4;實例5;實例6A;實例7A;實例9A;實例10A. | 灰白色固體 | |
404 | 實例4;實例5;實例6A;實例7A;實例9A;實例10A. | 淡棕色黏性固體 | |
405 | 實例4;實例5;實例6A;實例7A;實例9A;實例10A. | 棕色黏性固體 | |
406 | 實例4;實例5;實例6A;實例7A;實例9A;實例10A. | 棕色固體 | |
407 | 實例4;實例5;實例6A;實例7A;實例9A;實例10A. | 灰白色固體 | |
408 | 實例9C;實例10A. | 棕色油狀物 | |
409 | 實例9C;實例10A. | 棕色油狀物 | |
410 | 實例1B;實例9A;實例10A. | 澄清油狀物 | |
411 | 實例1B;實例9A;實例10A. | 澄清油狀物 | |
412 | 實例1B;實例9A;實例10A. | 澄清油狀物 | |
413 | 實例1B;實例9A;實例10A. | 澄清油狀物 | |
414 | 實例9A;實例10A. | 黃褐色半固體 | |
415 | 實例9A;實例10A. | 深棕色油狀物 | |
416 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 棕色油狀物 | |
417 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 棕色油狀物 | |
418 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 黃色油狀物 | |
419 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 灰白色固體 | |
420 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 棕色油狀物 | |
421 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 棕色油狀物 | |
422 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 棕色油狀物 | |
423 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 棕色油狀物 | |
424 | 實例9B;實例10D;實例12. | 澄清油狀物 | |
425 | 實例1B;實例2B;實例3B;實例9A;實例10A. | 澄清油狀物 | |
426 | 實例1B;實例2B;實例3B;實例9A;實例10A. | 無色油狀物 | |
427 | 實例1B;實例2B;實例3B;實例9A;實例10A. | 無色油狀物 | |
428 | 實例1B;實例2B;實例3B;實例9A;實例10A. | 無色油狀物 | |
429 | 實例1B;實例2B;實例3B;實例9A;實例10A. | 無色油狀物 | |
430 | 實例1C;實例6C;實例7B;實例9A;實例10D. | 黃色固體 | |
431 | 實例1C;實例6C;實例7B;實例9A;實例10D. | 灰白色半固體 | |
432 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 黃色油狀物 | |
433 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 黃色油狀物 | |
434 | 實例9A;實例10A. | 黃色固體 | |
435 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 灰白色固體 | |
436 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 淺黃色油狀物 | |
437 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 淺黃色油狀物 | |
438 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 淺黃色油狀物 | |
439 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 淺黃色油狀物 | |
440 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 淺黃色油狀物 | |
441 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 灰白色固體 | |
442 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 淺黃色油狀物 | |
443 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 淺黃色油狀物 | |
444 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 淺黃色油狀物 | |
445 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 淺黃色油狀物 | |
446 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 灰白色固體 | |
447 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 淺黃色油狀物 | |
448 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 淺黃色油狀物 | |
449 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 澄清油狀物 | |
450 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 淺黃色固體 | |
451 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 淺黃色半固體 | |
452 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 淺黃色固體 | |
453 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 淺黃色半固體 | |
454 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 淺黃色固體 | |
455 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 黃色油狀物 | |
456 | 實例9A;實例10A. | 淺黃色油狀物 | |
457 | 實例9A;實例10A. | 淺黃色油狀物 | |
458 | 實例6C;實例7B;實例9A;實例10A. | 米黃色半固體 | |
459 | 實例6C;實例7B;實例9A;實例10A. | 米黃色油狀物 | |
460 | 實例6C;實例7B;實例9A;實例10A. | 橙色油狀物 | |
461 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 澄清油狀物 | |
462 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 黃色油狀物 | |
463 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 澄清油狀物 | |
464 | 實例9A;實例10A. | 灰白色粉末 | |
465 | 實例9A;實例10A. | 灰白色半固體 | |
466 | 實例9A;實例10A. | 橙色油狀物 | |
467 | 實例9A;實例10A. | 棕色油狀物 | |
468 | 實例9A;實例10A. | 棕色油狀物 | |
469 | 實例9A;實例10A. | 棕色油狀物 | |
470 | 實例9A;實例10A. | 棕色油狀物 | |
471 | 實例9A;實例10A. | 灰白色半固體 | |
472 | 實例9A;實例10A. | 灰白色半固體 | |
473 | 實例9A;實例10A. | 灰白色半固體 | |
474 | 實例9A;實例10A. | 棕色油狀物 | |
475 | 實例9A;實例10A. | 灰白色半固體 | |
476 | 實例9A;實例10A. | 灰白色半固體 | |
477 | 實例9A;實例10A. | 棕色油狀物 | |
478 | 實例9A;實例10A. | 灰白色粉末 | |
479 | 實例9A;實例10A. | 棕色油狀物 | |
480 | 實例9A;實例10A. | 棕色油狀物 | |
481 | 實例9A;實例10A. | 棕色油狀物 | |
482 | 實例9A;實例10A. | 棕色半固體 | |
483 | 實例9A;實例10A. | 棕色油狀物 | |
484 | 實例9A;實例10A. | 深棕色油狀物 | |
485 | 實例9A;實例10A. | 棕色油狀物 | |
486 | 實例9A;實例10A. | 深棕色油狀物 | |
487 | 實例4;實例5;實例6C;實例7B;實例9A;實例10A. | 棕色油狀物 | |
488 | 實例4;實例5;實例6C;實例7B;實例9A;實例10A. | 棕色油狀物 | |
489 | 實例4;實例5;實例6C;實例7B;實例9A;實例10A. | 棕色半固體 | |
490 | 實例4;實例5;實例6C;實例7B;實例9A;實例10A. | 橙色油狀物 | |
491 | 實例4;實例5;實例6C;實例7B;實例9A;實例10A. | 橙色油狀物 | |
492 | 實例4;實例5;實例6C;實例7B;實例9A;實例10A. | 橙色油狀物 | |
493 | 實例9B;實例10B;實例13. | 淺棕色固體 | |
494 | 實例9B;實例10B;實例13. | 灰白色固體 | |
495 | 實例9B;實例10B;實例13. | 灰白色固體 | |
496 | 實例9A;實例10A. | 灰白色半固體 | |
497 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 淺黃色油狀物 | |
498 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 淺黃色油狀物 | |
499 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 淺黃色油狀物 | |
500 | 實例9A;實例10A. | 黃色油狀物 | |
501 | 實例9A;實例10A. | 澄清油狀物 | |
502 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 淺黃色油狀物 | |
503 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 淺黃色油狀物 | |
504 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 淺黃色油狀物 | |
505 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 淺黃色油狀物 | |
506 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 淺黃色油狀物 | |
507 | 實例9A;實例10A. | 棕色油狀物 | |
508 | 實例9A;實例10A. | 棕色油狀物 | |
509 | 實例9A;實例10A. | 灰白色半固體 | |
510 | 實例9A;實例10A. | 橙色半固體 | |
511 | 實例9A;實例10A. | 灰白色半固體 | |
512 | 實例9A;實例10A. | 棕色油狀物 | |
513 | 實例9A;實例10A. | 棕色油狀物 | |
514 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 黃色油狀物 | |
515 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 黃色油狀物 | |
516 | 實例9A;實例10A. | 黃色油狀物 | |
517 | 實例9A;實例10A. | 黃色油狀物 | |
518 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 灰白色固體 | |
519 | 實例6C;實例7B;實例9A;實例10A. | 淺黃色油狀物 | |
520 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 淺黃色油狀物 | |
521 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 淺黃色油狀物 | |
522 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 白色固體 | |
523 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 白色固體 | |
524 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 黃色油狀物 | |
525 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 黃色油狀物 | |
526 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 黃色油狀物 | |
527 | 實例9A;實例10A. | 黃色油狀物 | |
528 | 實例1C;實例6C;實例7B;實例9A;實例10A. | 黃色半固體 | |
529 | 實例9A;實例10A. | 棕色油狀物 | |
530 | 實例9A;實例10A. | 棕色油狀物 | |
531 | 實例9A;實例10A. | 黃色油狀物 | |
532 | 實例9A;實例10A. | 黃色油狀物 | |
533 | 實例9A;實例10A. | 黃色油狀物 | |
534 | 實例9A;實例10A. | 黃色油狀物 | |
535 | 實例9A;實例10A. | 黃色油狀物 | |
536 | 實例9A;實例10A. | 黃色油狀物 | |
537 | 實例9A;實例10A. | 黃色油狀物 | |
538 | 實例9A;實例10A. | 黃色油狀物 | |
539 | 實例9A;實例10A. | 黃色油狀物 | |
540 | 實例9A;實例10A. | 黃色油狀物 | |
541 | 實例9A;實例10A. | 黃色油狀物 | |
542 | 實例9A;實例10A. | 黃色油狀物 | |
543 | 實例9A;實例10A. | 黃色油狀物 | |
544 | 實例9A;實例10A. | 黃色油狀物 | |
545 | 實例9A;實例10A. | 黃色油狀物 | |
546 | 實例9A;實例10A. | 黃色油狀物 | |
547 | 實例9A;實例10A. | 黃色油狀物 | |
548 | 實例9A;實例10A. | 黃色油狀物 | |
549 | 實例9A;實例10A. | 黃色油狀物 | |
550 | 實例9A;實例10A. | 黃色油狀物 | |
551 | 實例9A;實例10A. | 黃色油狀物 | |
552 | 實例9A;實例10A. | 黃色油狀物 | |
553 | 實例9A;實例10A. | 黃色油狀物 | |
554 | 實例9A;實例10A. | 黃色油狀物 | |
555 | 實例9A;實例10A. | 黃色油狀物 | |
556 | 實例9A;實例10A. | 黃色油狀物 | |
557 | 實例9A;實例10A. | 黃色油狀物 | |
558 | 實例9A;實例10A. | 黃色油狀物 | |
559 | 實例9A;實例10A. | 黃色油狀物 | |
560 | 實例9B;實例10A;實例13. | 灰白色固體 | |
561 | 實例9B;實例10A;實例13. | 灰白色固體 | |
562 | 實例9B;實例10A;實例13. | 棕色油狀物 | |
563 | 實例9B;實例10A;實例13. | 灰白色固體 |
化合物編號 | IR ( cm-1 ) | 熔點( °C ) | 質量 | NMR ( 1 H 、 13 C 或 19 F ) |
1 | ESIMSm/z 249 ([M+H]+ ) | 1 H NMR(400 MHz, CDCl3 ) δ 7.75 (s, 1H), 7.47 (s, 1H), 6.57 (s, 1H), 3.85 (s, 3H), 3.41 (d,J = 66.1 Hz, 2H), 3.01 (s, 3H), 2.54 (s, 3H), 2.24 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 | ||
2 | > 250 | ESIMSm/z 235 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 11.19 (s, 1H), 8.47 (s, 1H), 7.31 (s, 1H), 3.30 (s, 3H), 3.29 (s, 3H), 2.54 (s, 3H), 2.36 (s, 3H), 1.27 (t,J = 7.1 Hz, 3H)。 | |
3 | (薄膜)2970, 2922, 1589, 1119, 1101 | ESIMSm/z 310 ([M]+ ) | 1 H NMR(300 MHz, CDCl3 ) δ 8.00 (s, 1H), 7.52 (s, 1H), 7.46 - 7.37 (m, 2H), 7.25 - 7.15 (m, 3H), 6.63 (s, 1H), 3.45 (d,J = 56.5 Hz, 2H), 3.04 (s, 3H), 2.60 (s, 3H), 2.29 (s, 3H), 1.24 (t,J = 7.1 Hz, 3H)。 | |
4 | (薄膜)2971, 1631, 1591, 1243, 1084 | ESIMSm/z 344 ([M+H]+ ) | 1 H NMR(300 MHz, CDCl3 ) δ 7.74 (s, 1H), 7.47 (s, 1H), 6.58 (s, 1H), 4.32 (t,J = 6.2 Hz, 2H), 3.34 (s, 2H), 3.02 (s, 3H), 2.54 (s, 3H), 2.37 - 2.17 (m, 5H), 2.11 - 1.94 (m, 2H), 1.23 (t,J = 7.1 Hz, 3H)。 | |
5 | 113-122 | ESIMSm/z 368 ([M+H]+ ) | 1 H NMR(400 MHz, CDCl3 ) δ 7.57 - 7.40 (m, 3H), 7.33 (s, 1H), 7.29 (dd,J = 7.6, 1.5 Hz, 1H), 7.25 - 7.18 (m, 1H), 6.65 (s, 1H), 3.43 (bd,J = 7.2 Hz, 2H), 3.03 (s, 3H), 2.52 (s, 3H), 2.19 (s, 3H), 1.24 (t,J = 7.3, 5.8 Hz, 3H)。 | |
6 | (薄膜)2971, 2922, 1726, 1629, 1588, 1118, 1098 | ESIMSm/z 381 ([M+H]+ ) | 1 H NMR(400 MHz, CDCl3 ) δ 7.95 (s, 1H), 7.53 (s, 1H), 7.47 (d,J = 8.7 Hz, 1H), 7.36 (d,J = 2.7 Hz, 1H), 7.08 (dd,J = 8.7, 2.6 Hz, 1H), 6.63 (s, 1H), 3.45 (bd,J = 76.7 Hz, 2H), 3.04 (s, 3H), 2.59 (s, 3H), 2.29 (s, 3H), 1.24 (t,J = 6.9 Hz, 3H)。 | |
7 | 95-97 | ESIMSm/z 379 ([M+H]+ ) | 1 H NMR(400 MHz, CDCl3 ) δ 7.99 (s, 1H), 7.69 (d,J = 8.5 Hz, 2H), 7.54 (s, 1H), 7.32 (d,J = 8.3 Hz, 2H), 6.64 (s, 1H), 3.45 (bd,J = 76.7 Hz, 2H), 3.05 (s, 3H), 2.60 (s, 3H), 2.30 (s, 3H), 1.25 (t,J = 7.1 Hz, 3H)。 | |
8 | ESIMSm/z 325 ([M+H]+ ) | 1 H NMR(300 MHz, CDCl3 ) δ 7.99 (d,J = 0.9 Hz, 1H), 7.51 (s, 1H), 7.24 - 7.16 (m, 2H), 7.10 - 7.03 (m, 2H), 6.63 (s, 1H), 3.44 (bd,J = 5.39 Hz, 2H), 3.03 (s, 3H), 2.60 (s, 3H), 2.36 (s, 3H), 2.29 (s, 3H), 1.23 (t,J = 7.1 Hz, 3H)。 | ||
9 | 78-80 | ESIMSm/z 345 ([M+H]+ ) | 1 H NMR(300 MHz, CDCl3 ) δ 7.98 (s, 1H), 7.52 (s, 1H), 7.40 - 7.34 (m, 2H), 7.17 - 7.10 (m, 2H), 6.63 (s, 1H), 3.44 (bd,J = 54.2 Hz, 2H), 3.04 (s, 3H), 2.59 (s, 3H), 2.29 (s, 3H), 1.24 (t,J = 7.1 Hz, 3H)。 | |
10 | 110-118 | ESIMSm/z 380 ([M+H]+ ) | 1 H NMR(300 MHz, CDCl3 ) δ 8.04 (s, 1H), 7.53 (bs, 1H),7.49 (d,J = 2.4 Hz, 1H), 7.31 (d,J = 2.4 Hz, 0.36 H), 7.28 (d,J = 2.4 Hz, 0.64H), 7.20 (s, 0.64H), 7.17 (s, 0.36H), 6.64 (s, 1H), 3.45 (bd,J = 55.7 Hz, 2H), 3.04 (s, 3H), 2.60 (s, 3H), 2.29 (s, 3H), 1.24 (t,J = 7.2 Hz, 3H)。 | |
11 | 60-63 | EIMSm/z 340 ([M]+ ) | 1 H NMR(400 MHz, CDCl3 ) δ 7.98 (s, 1H), 7.52 (s, 1H), 7.14 - 7.07 (m, 2H), 6.97 - 6.89 (m, 2H), 6.63 (s, 1H), 3.82 (s, 3H), 3.44 (bd,J = 75.8 Hz, 2H), 3.04 (s, 3H), 2.60 (s, 3H), 2.29 (s, 3H), 1.24 (t,J = 7.1 Hz, 3H)。 | |
12 | (薄膜)2921, 1628, 1587, 1542 | 1 H NMR(400 MHz, CDCl3 ) δ 8.06 (s, 1H), 7.93 - 7.79 (m, 3H), 7.66 (d,J = 2.3 Hz, 1H), 7.60 - 7.40 (m, 3H), 7.35 (dd,J = 8.8, 2.3 Hz, 1H), 6.66 (s, 1H), 3.45 (bd,J = 73.3 Hz, 2H), 3.05 (s, 3H), 2.63 (s, 3H), 2.31 (s, 3H), 1.25 (t,J = 7.1 Hz, 3H)。 | ||
13 | (薄膜)2922, 1719, 1628, 1587, 1099, 1082 | ESIMSm/z 362 ([M+H]+ ) | 1 H NMR(400 MHz, CDCl3 ) δ 8.91 (dd,J = 4.2, 1.7 Hz, 1H), 8.20 - 8.10 (m, 2H), 8.06 (s, 1H), 7.67 (d,J = 2.6 Hz, 1H), 7.59 (dd,J = 9.1, 2.6 Hz, 1H), 7.55 (s, 1H), 7.42 (dd,J = 8.3, 4.2 Hz, 1H), 6.66 (s, 1H), 3.46 (bd,J = 76.8 Hz, 2H), 3.05 (s, 3H), 2.63 (s, 3H), 2.32 (s, 3H), 1.25 (t,J = 7.1 Hz, 3H)。 | |
14 | (薄膜)2923, 1726, 1629, 1588, 1200, 1128, 1080 | ESIMSm/z 346 ([M+H]+ ) | 1 H NMR(400 MHz, CDCl3 ) δ 8.40 (d,J = 2.7 Hz, 1H), 8.04 (s, 1H), 7.78 (dd,J = 8.6, 2.7 Hz, 1H), 7.54 (s, 1H), 7.16 (d,J = 8.6 Hz, 1H), 6.63 (s, 1H), 3.45 (d,J = 75.6 Hz, 2H), 3.04 (s, 3H), 2.60 (s, 3H), 2.28 (s, 3H), 1.24 (t,J = 7.0 Hz, 3H)。 | |
15 | ESIMSm/z 346 ([M+H]+ ) | 1 H NMR(400 MHz, CDCl3 ) δ 8.47 (d,J = 2.1 Hz, 1H), 8.44 (d,J = 2.3 Hz, 1H), 7.98 (s, 1H), 7.65 (t,J = 2.2 Hz, 1H), 7.54 (bs, 1H), 6.65 (s, 1H), 3.36 (bd, 2H), 3.05 (s, 3H), 2.60 (s, 3H), 2.29 (s, 3H), 1.25 (t,J = 7.1 Hz, 3H)。 | ||
16 | (薄膜)1705, 1631, 1592, 1245 | ESIMSm/z 349 ([M+H]+ ) | 1 H NMR(300 MHz, CDCl3 ) δ 7.74 (s, 1H), 7.45 (s, 1H), 6.55 (s, 1H), 4.19 (t,J = 7.0 Hz, 2H), 3.27 (bd,J = 29.9 Hz, 2H), 3.00 (s, 3H), 2.53 (s, 3H), 2.23 (s, 3H), 1.82 - 1.60 (m, 2H), 1.20 (t,J = 7.1 Hz, 3H), 0.66 - 0.45 (m, 2H), 0.01 (s, 9H)。 | |
17 | (薄膜)2923, 1703, 1629, 1591, 1245, 1106 | ESIMSm/z 289 ([M+H]+ ) | 1 H NMR(300 MHz, CDCl3 ) δ 7.78 (s, 1H), 7.46 (s, 1H), 6.57 (s, 1H), 4.09 (d,J = 7.2 Hz, 2H), 3.29 (bd,J = 31.1 Hz, 2H), 3.02 (s, 3H), 2.55 (s, 3H), 2.25 (s, 3H), 1.31 - 1.18 (m, 4H), 0.68 - 0.51 (m, 2H), 0.41 - 0.30 (m, 2H)。 | |
18 | ESIMSm/z 325 ([M+H]+ ) | 1 H NMR(300 MHz, CDCl3 ) δ 7.80 (s, 1H), 7.55 - 7.27 (m, 6H), 6.57 (s, 1H), 5.31 (s, 2H), 3.29 (bd,J = 29.3 Hz, 2H), 3.01 (s, 3H), 2.55 (s, 3H), 2.23 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 | ||
19 | ESIMSm/z 326 ([M+2H] + ) | 1 H NMR(400 MHz, CDCl3 ) δ 7.77 (s, 1H), 7.48 (s, 1H), 6.58 (s, 1H), 4.52 - 4.09 (m, 2H), 3.42 (bd,J = 68.8 Hz, 2H), 3.02 (s, 3H), 2.55 (s, 3H), 2.25 (s, 3H), 2.16 - 2.03 (m, 1H), 1.60 - 1.51 (m, 1H), 1.34 - 1.18 (m, 4H)。 | ||
20 | ESIMSm/z 317 ([M+H]+ ) | 1 H NMR(400 MHz, CDCl3 ) δ 7.74 (s, 1H), 7.45 (s, 1H), 6.56 (s, 1H), 4.98 (dt,J = 9.0, 4.9 Hz, 1H), 3.31 - 3.37 (bd, 2H), 3.01 (s, 3H), 2.54 (s, 3H), 2.25 (s, 3H), 1.91 - 2.00 (m, 2H), 1.77 - 1.83 (m, 2H), 1.51 - 1.29 (m, 6H), 1.22 (t,J = 7.2 Hz, 3H)。 | ||
21 | ESIMSm/z 332 ([M+2H] + ) | 1 H NMR(400 MHz, CDCl3 ) δ 7.75 (s, 1H), 7.46 (s, 1H), 6.57 (s, 1H), 4.07 (d,J = 6.4 Hz, 2H), 3.41 (bd,J = 62.5 Hz, 2H), 3.01 (s, 3H), 2.55 (s, 3H), 2.25 (s, 3H), 1.90 - 1.62 (m, 5H), 1.37 - 1.14 (m, 7H), 1.12 - 0.98 (m, 2H)。 | ||
22 | ESIMSm/z 291 ([M+H]+ ) | 1 H NMR(400 MHz, CDCl3 ) δ 7.77 (s, 1H), 7.47 (s, 1H), 6.57 (s, 1H), 4.05 (d,J = 6.6 Hz, 2H), 3.41 (bd,J = 62.9 Hz, 2H), 3.01 (s, 3H), 2.55 (s, 3H), 2.25 (s, 3H), 2.06 (dq,J = 13.4, 6.7 Hz, 1H), 1.22 (t,J = 7.1 Hz, 3H), 1.02 (d,J = 6.7 Hz, 6H)。 | ||
23 | ESIMSm/z 339 ([M+H]+ ) | 1 H NMR(400 MHz, CDCl3 ) δ 7.71 (s, 1H), 7.46 (s, 1H), 7.37 - 7.18 (m, 5H), 6.55 (s, 1H), 4.47 (t,J = 7.1 Hz, 2H), 3.41 (bd,J = 66.6 Hz, 2H), 3.07 (t,J = 7.1 Hz, 2H), 3.01 (s, 3H), 2.50 (s, 3H), 2.23 (s, 3H), 1.21 (t,J = 7.1 Hz, 3H)。 | ||
24 | ESIMSm/z 314 ([M+2H] + ) | 1 H NMR(400 MHz, CDCl3 ) δ 7.78 (s, 1H), 7.49 (s, 1H), 6.59 (s, 1H), 4.42 (t,J = 12.2 Hz, 2H), 3.43 (bd,J = 71.1 Hz, 2H), 3.02 (s, 3H), 2.55 (s, 3H), 2.25 (s, 3H), 1.73 (t,J = 18.6 Hz, 3H), 1.23 (t,J = 7.1 Hz, 3H)。 | ||
25 | (薄膜)2228, 1631, 1591, 1245, 1107 | ESIMSm/z 393 ([M+H]+ ) | 1 H NMR(400 MHz, CDCl3 ) δ 7.80 (s, 1H), 7.70 (s, 1H), 7.64 (d,J = 7.7 Hz, 1H), 7.59 (d,J = 7.9 Hz, 1H), 7.49 (d,J = 7.6 Hz, 2H), 6.58 (s, 1H), 5.35 (s, 2H), 3.42 (bd,J = 72.4 Hz, 2H), 3.02 (s, 3H), 2.55 (s, 3H), 2.24 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 | |
26 | (薄膜)1708, 1631, 1591, 1107, 1065 | ESIMSm/z 393 ([M+H]+ ) | 1 H NMR(400 MHz, CDCl3 ) δ 7.81 (s, 1H), 7.64 (d,J = 8.2 Hz, 2H), 7.56 (d,J = 8.0 Hz, 2H), 7.49 (s, 1H), 6.58 (s, 1H), 5.36 (s, 2H), 3.42 (bd,J = 69.6 Hz, 2H), 3.02 (s, 3H), 2.55 (s, 3H), 2.24 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 | |
27 | (薄膜)1631, 1591, 1243, 1106 | ESIMSm/z 410 ([M+2H] + ) | 1 H NMR(400 MHz, CDCl3 ) δ 7.79 (s, 1H), 7.51 - 7.42 (m, 3H), 7.24 - 7.19 (m, 2H), 6.58 (s, 1H), 5.30 (s, 2H), 3.42 (d,J = 71.2 Hz, 2H),3.02 (s, 3H), 2.55 (s, 3H), 2.24 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 | |
28 | (薄膜)1708, 1630, 1589, 1242, 1104 | ESIMSm/z 393 ([M+H]+ ) | 1 H NMR(400 MHz, CDCl3 ) δ 7.81 (s, 1H), 7.52 - 7.41 (m, 3H), 7.26 (dd,J = 8.2, 2.2 Hz, 1H), 6.58 (s, 1H), 5.37 (s, 2H), 3.42 (bd,J = 71.9 Hz, 2H), 3.02 (s, 3H), 2.55 (s, 3H), 2.24 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 | |
29 | (薄膜)1706, 1630, 1590, 1242, 1105 | ESIMSm/z 393 ([M+H]+ ) | 1 H NMR(400 MHz, CDCl3 ) δ 7.78 (s, 1H), 7.54 (d,J = 2.0 Hz, 1H), 7.45 (d,J = 8.3 Hz, 1H), 7.29 (d,J = 2.1 Hz, 1H), 7.27 (d,J = 1.9 Hz, 1H), 6.58 (s, 1H), 5.24 (s, 2H), 3.42 (bd,J = 73.0 Hz, 2H), 3.02 (s, 3H), 2.54 (s, 3H), 2.24 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 | |
30 | ESIMSm/z 339 ([M+H]+ ) | 1 H NMR(400 MHz, CDCl3 ) δ 7.78 (s, 1H), 7.46 (bs, 1H), 7.34 (d,J = 7.9 Hz, 2H), 7.19 (d,J = 7.8 Hz, 2H), 6.56 (s, 1H), 5.26 (s, 2H), 3.41 (bd,J = 66.7 Hz, 2H), 3.01 (s, 3H), 2.55 (s, 3H), 2.36 (s, 3H), 2.22 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 | ||
31 | (薄膜)1707, 1630, 1590, 1243, 1106 | ESIMSm/z 350 ([M+H]+ ) | 1 H NMR(400 MHz, CDCl3 ) δ 7.81 (s, 1H), 7.69 - 7.65 (m, 2H), 7.54 (d,J = 8.1 Hz, 2H), 7.49 (bs, 1H), 6.59 (s, 1H), 5.35 (s, 2H), 3.43 (bd,J = 73.5 Hz, 2H), 3.02 (s, 3H), 2.55 (s, 3H), 2.25 (s, 3H), 1.23 (t,J = 7.1 Hz, 3H)。 | |
32 | (薄膜)1705, 1631, 1592, 1242, 1107 | ESIMSm/z 355 ([M+H]+ ) | 1 H NMR(400 MHz, CDCl3 ) δ 7.76 (s, 1H), 7.46 (bs, 1H), 7.43 - 7.32 (m, 2H), 6.94 - 6.87 (m, 2H), 6.56 (s, 1H), 5.24 (s, 2H), 3.82 (s, 3H), 3.42 (bd,J = 72.3 Hz, 2H), 3.01 (s, 3H), 2.54 (s, 3H), 2.22 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 | |
33 | (薄膜)1703, 1530, 1591, 1241, 1107 | ESIMSm/z 369 ([M+H]+ ) | 1 H NMR(400 MHz, CDCl3 ) δ 7.77 (s, 1H), 7.45 (bs, 1H), 6.96 - 6.89 (m, 2H), 6.80 (d,J = 7.9 Hz, 1H), 6.56 (s, 1H), 5.97 (s, 2H), 5.20 (s, 2H), 3.34 (bd,J = 54.2 Hz, 2H), 3.01 (s, 3H), 2.54 (s, 3H), 2.23 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 | |
34 | 69-71 | 1 H NMR(400 MHz, CDCl3 ) δ 7.98 (s, 1H), 7.53 (bs, 1H), 7.21 - 7.27 (m, 4H), 6.64 (s, 1H), 3.45 (bd,J = 74.8 Hz, 2H), 3.04 (s, 3H), 2.60 (s, 3H), 2.29 (s, 3H), 1.24 (t,J = 7.1 Hz, 3H)。 | ||
35 | (薄膜)2973, 2925, 1726, 1590, 1083 | ESIMSm/z 379 ([M+H]+ ) | 1 H NMR(400 MHz, CDCl3 ) δ 8.00 (s, 1H), 7.57 - 7.46 (m, 4H), 7.43 - 7.38 (m, 1H), 6.64 (s, 1H), 3.45 (bd,J = 74.9 Hz, 2H), 3.05 (s, 3H), 2.60 (s, 3H), 2.29 (s, 3H), 1.24 (t,J = 7.2 Hz, 3H)。 | |
36 | (薄膜)2970, 2922, 1727, 1588, 1205, 1083 | ESIMSm/z 391 ([M+2H] + ) | 1 H NMR(400 MHz, CDCl3 ) δ 8.09 (s, 1H), 7.64 (dd,J = 8.0, 1.5 Hz, 1H), 7.52 (bs, 1H), 7.36 (td,J = 7.7, 1.5 Hz, 1H), 7.24 (dd,J = 8.1, 1.6 Hz, 1H), 7.13 (td,J = 7.7, 1.6 Hz, 1H), 6.64 (s, 1H), 3.45 (bd,J = 75.6 Hz, 2H), 3.04 (s, 3H), 2.62 (s, 3H), 2.30 (s, 3H), 1.24 (t,J = 7.1 Hz, 3H)。 | |
37 | (薄膜)2958, 1630, 1591, 1244, 1106 | ESIMSm/z 367 ([M+H]+ ) | 1 H NMR(300 MHz, CDCl3 ) δ 7.79 (s, 1H), 7.46 (bs, 1H), 7.38 (d,J = 8.1 Hz, 2H), 7.24 (d,J = 8.0 Hz, 2H), 6.57 (s, 1H), 5.27 (s, 2H), 3.42 (bd,J = 48.8 Hz, 2H), 3.01 (s, 3H), 2.92 (p,J = 7.0 Hz, 1H), 2.55 (s, 3H), 2.23 (s, 3H), 1.36 - 1.12 (m, 9H)。 | |
38 | (薄膜)2924, 1704, 1630, 1590, 1244, 1106 | ESIMSm/z 365 ([M+H]+ ) | 1 H NMR(300 MHz, CDCl3 ) δ 7.78 (s, 1H), 7.46 (bs, 1H), 7.36 - 7.30 (m, 2H), 7.10 - 7.06 (m, 2H), 6.56 (s, 1H), 5.25 (s, 2H), 3.33 (bd,J = 55.7 Hz, 2H), 3.01 (s, 3H), 2.54 (s, 3H), 2.22 (s, 3H), 1.90 (ddd,J = 13.4, 8.4, 5.0 Hz, 1H), 1.22 (t,J = 7.1 Hz, 3H), 1.01 - 0.91 (m, 2H), 0.73 - 0.66 (m, 2H)。 | |
39 | (薄膜)2924, 1711, 1590, 1242, 1104 | ESIMSm/z 384 ([M+2H] + ) | 1 H NMR(300 MHz, CDCl3 ) δ 8.08 - 8.02 (m, 2H), 7.81 (s, 1H), 7.54 - 7.47 (m, 3H), 6.58 (s, 1H), 5.36 (s, 2H), 3.92 (s, 3H), 3.43 (bd,J = 49.9 Hz, 2H), 3.02 (s, 3H), 2.55 (s, 3H), 2.24 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 | |
40 | (薄膜)2964, 2925, 1629, 1590, 1243, 1105 | ESIMSm/z 353 ([M+H]+ ) | 1 H NMR(300 MHz, CDCl3 ) δ 7.79 (s, 1H), 7.46 (bs, 1H), 7.37 (d,J = 7.9 Hz, 2H), 7.21 (d,J = 7.9 Hz, 2H), 6.56 (s, 1H), 5.27 (s, 2H), 3.34 (bs, 2H), 3.01 (s, 3H), 2.66 (q,J = 7.6 Hz, 2H), 2.55 (s, 3H), 2.22 (s, 3H), 2.19 - 1.23 (m, 6H)。 | |
41 | (薄膜)2923, 1706, 1629, 1589, 1242, 1105 | ESIMSm/z 360 ([M+2H] + ) | 1 H NMR(300 MHz, CDCl3 ) δ 7.78 (s, 1H), 7.47 (bs, 1H), 7.42 - 7.31 (m, 4H), 6.57 (s, 1H), 5.26 (s, 2H), 3.34 (bs, 2H), 3.02 (s, 3H), 2.54 (s, 3H), 2.23 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 | |
42 | (薄膜)2983, 2919, 1706, 1628, 1254, 1075 | ESIMSm/z 407 ([M+H]+ ) | 1 H NMR(300 MHz, CDCl3 ) δ 7.80 (s, 1H), 7.42 - 7.46 (m, 3H), 7.31 (d,J = 7.9 Hz, 2H), 6.57 (s, 1H), 5.31 (s, 2H), 3.36 - 3.38 (m, 4H), 3.02 (s, 3H), 2.55 (s, 3H), 2.24 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 | |
43 | (薄膜)2923, 1705, 1590, 1244, 1105 | ESIMSm/z 370 ([M+2H] + ) | 1 H NMR(300 MHz, CDCl3 ) δ 7.79 (s, 1H), 7.44 - 7.49 (m, 3H), 7.35 (d,J = 8.0 Hz, 2H), 6.57 (s, 1H), 5.30 (s, 2H), 4.47 (s, 2H), 3.27 - 3.54 (s, 5H), 3.01 (s, 3H), 2.55 (s, 3H), 2.23 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 | |
44 | (薄膜)2922, 1705, 1630, 1591, 1243, 1106 | ESIMSm/z 340 ([M+2H] + ) | 1 H NMR(300 MHz, CDCl3 ) δ 7.80 (s, 1H), 7.46 (s, 1H), 7.27 (d,J = 6.2 Hz, 3H), 7.16 - 7.11 (m, 1H), 6.57 (s, 1H), 5.27 (s, 2H), 3.34 (bd,J = 64.4 Hz, 2H), 3.02 (s, 3H), 2.55 (s, 3H), 2.37 (s, 3H), 2.23 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 | |
45 | (薄膜)2923, 1708, 1631, 1591, 1245, 1107 | ESIMSm/z 339 ([M+H]+ ) | 1 H NMR(300 MHz, CDCl3 ) δ 7.78 (s, 1H), 7.50 - 7.39 (m, 2H), 7.25 - 7.17 (m, 3H), 6.57 (s, 1H), 5.31 (s, 2H), 3.29 (bd,J = 29.6 Hz, 2H), 3.01 (s, 3H), 2.55 (s, 3H), 2.41 (s, 3H), 2.22 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 | |
46 | (薄膜)2922, 1712, 1631, 1592, 1245, 1085 | ESIMSm/z 373 ([M+H]+ ) | 1 H NMR(300 MHz, CDCl3 ) δ 7.81 (s, 1H), 7.46 (s, 1H), 7.38 (d,J = 7.8 Hz, 1H), 7.23 (d,J = 1.4 Hz, 1H), 7.08 (d,J = 7.8 Hz, 1H), 6.57 (s, 1H), 5.37 (s, 2H), 3.34 (bs, 2H), 3.02 (s, 3H), 2.55 (s, 3H), 2.34 (s, 3H), 2.24 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 | |
47 | (薄膜)2924, 1711, 1591, 1243, 1106 | ESIMSm/z 353 ([M+H]+ ) | 1 H NMR(300 MHz, CDCl3 ) δ 7.78 (s, 1H), 7.45 (s, 1H), 7.17 (dd,J = 17.5, 8.7 Hz, 3H), 6.56 (s, 1H), 5.24 (bs, 2H), 3.34 (s, 2H), 3.01 (s, 3H), 2.55 (s, 3H), 2.28 (s, 3H), 2.26 (s, 3H), 2.22 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 | |
48 | (薄膜)2969, 1713, 1628, 1593, 1240, 1110 | ESIMSm/z 372 ([M]+ ) | 1 H NMR(300 MHz, CDCl3 ) δ 7.76 (s, 1H), 7.47 (s, 1H), 7.35 (d,J = 7.9 Hz, 1H), 7.23 - 7.15 (m, 2H), 6.57 (s, 1H), 5.26 (s, 2H), 3.29 (bd,J = 29.0 Hz, 2H), 3.02 (s, 3H), 2.54 (s, 3H), 2.39 (s, 3H), 2.23 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 | |
49 | (薄膜)1713, 1363, 1222, 1107 | ESIMSm/z 401 ([M+H]+ ) | 1 H NMR(300 MHz, CDCl3 ) δ 7.82 (s, 1H), 7.64 - 7.57 (m, 4H), 7.56 - 7.39 (m, 5H), 7.39 - 7.31 (m, 1H), 6.58 (s, 1H), 5.37 (s, 2H), 3.34 (s, 2H), 3.02 (s, 3H), 2.57 (s, 3H), 2.24 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 | |
50 | (薄膜)2929, 1629, 1590, 1238, 1106 | ESIMSm/z 385 ([M+H]+ ) | 1 H NMR(300 MHz, CDCl3 ) δ 7.77 (s, 1H), 7.46 (s, 1H), 7.05 - 6.97 (m, 2H), 6.87 (d,J = 8.1 Hz, 1H), 6.57 (s, 1H), 5.24 (s, 2H), 3.90 (s, 3H), 3.89 (s, 3H),3.34 (bs, 2H), 3.01 (s, 3H), 2.55 (s, 3H), 2.22 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 | |
51 | (薄膜)2923, 1711, 1631, 1591, 1244, 1106 | ESIMSm/z 356 ([M]+ ) | 1 H NMR(300 MHz, CDCl3 ) δ 7.77 (s, 1H), 7.46 (s, 1H), 7.35 (t,J = 7.7 Hz, 1H), 6.93 (dd,J = 12.8, 9.5 Hz, 2H), 6.56 (s, 1H), 5.32 (s, 2H), 3.33 (bs, 2H), 3.01 (s, 3H), 2.54 (s, 3H), 2.36 (s, 3H), 2.22 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 | |
52 | (薄膜)2924, 1630, 1591, 1246, 1107 | ESIMSm/z 365 ([M+2H] + ) | 1 H NMR(300 MHz, CDCl3 ) δ 7.79 (s, 1H), 7.50 - 7.41 (m, 3H), 7.35 (d,J = 8.1 Hz, 2H), 6.58 (s, 1H), 5.30 (s, 2H), 3.76 (s, 2H), 3.31 (bd,J = 18.5 Hz, 2H), 3.02 (s, 3H), 2.55 (s, 3H), 2.24 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 | |
53 | (薄膜)2951, 2926, 1631, 1593, 1248, 730 | ESIMSm/z 303 ([M+H]+ ) | ||
54 | (薄膜)2923, 1631, 1593, 1246, 1108 | ESIMSm/z 304 ([M+2H] + ) | 1 H NMR(400 MHz, CDCl3 ) δ 7.78 (s, 1H), 7.47 (s, 1H), 6.58 (s, 1H), 4.06 (s, 2H), 3.43 (bd,J = 64.9 Hz, 2H), 3.04 (s, 3H), 2.56 (s, 3H), 2.26 (s, 3H), 1.21 - 1.25 (m, 6H), 0.59 - 0.48 (m, 2H), 0.48 - 0.36 (m, 2H)。 | |
55 | (薄膜)2971, 2932, 1704, 1631, 1592, 1249, 1108, 731 | ESIMSm/z 304 ([M+2H] + ) | 1 H NMR(400 MHz, CDCl3 ) δ 7.75 (s, 1H), 7.46 (s, 1H), 6.57 (s, 1H), 4.23 (d,J = 6.8 Hz, 2H), 3.42 (bd,J = 64.8 Hz, 2H), 3.02 (s, 3H), 2.75 (hept,J = 7.2 Hz, 1H), 2.53 (s, 3H), 2.25 (s, 3H), 2.17 - 2.04 (m, 2H), 2.02 - 1.80 (m, 4H), 1.22 (t,J = 7.1 Hz, 3H)。 | |
56 | (薄膜)2969, 2923, 1629, 1590, 1243, 1106, 711 | ESIMSm/z 326 ([M+H]+ ) | 1 H NMR(400 MHz, CDCl3 ) δ 8.75 - 8.69 (m, 1H), 8.59 (dd,J = 4.9, 1.7 Hz, 1H), 7.83 - 7.74 (m, 2H), 7.48 (s, 1H), 7.32 (ddd,J = 7.8, 4.9, 0.9 Hz, 1H), 6.58 (s, 1H), 5.32 (s, 2H), 3.42 (bd,J = 71.1 Hz, 2H), 3.02 (s, 3H), 2.55 (s, 3H), 2.23 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 | |
57 | (薄膜)2974, 1632, 1592, 1109, 731 | ESIMSm/z 394 ([M+H]+ ) | 1 H NMR(400 MHz, CDCl3 ) δ 7.93 - 7.85 (m, 2H), 7.63 (t,J = 7.8 Hz, 2H), 7.50 (s, 1H), 6.60 (s, 1H), 5.50 (s, 2H), 3.43 (d,J = 70.1 Hz, 2H), 3.03 (s, 3H), 2.57 (s, 3H), 2.26 (s, 3H), 1.23 (t,J = 7.1 Hz, 3H)。 | |
58 | (薄膜)2976, 2927, 1701, 1631, 1592, 1246, 1109, 1058, 908, 815, 730 | 對於C22 H29 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為353.2224;實測值為353.2214 | 1 H NMR(400 MHz, CDCl3 ) δ 7.79 (s, 1H), 7.34 (d,J = 8.0 Hz, 2H), 7.20 - 7.12 (m, 1H), 6.56 (s, 1H), 6.06 (p,J = 6.6 Hz, 2H), 3.41 (d,J = 68.9 Hz, 3H), 3.01 (s, 3H), 2.53 (s, 3H), 2.34 (s, 3H), 2.24 (s, 3H), 1.63 (d,J = 6.6 Hz, 3H), 1.21 (t,J = 7.2 Hz, 3H)。 | |
59 | (薄膜)2974, 2923, 1708, 1632, 1593, 1548, 1257, 1107, 816 | 對於C23 H31 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為367.2380;實測值為367.2370 | 1 H NMR(400 MHz, CDCl3 ) δ 7.78 (s, 1H), 7.44 (s, 1H), 7.36 - 7.27 (m, 2H), 7.13 (d,J = 8.0 Hz, 2H), 6.54 (s, 1H), 3.25 (d,J = 64.1 Hz, 2H), 3.01 (s, 3H), 2.50 (s, 3H), 2.31 (s, 3H), 2.25 (s, 3H), 1.87 (s, 6H), 1.21 (t,J = 7.1 Hz, 3H)。 | |
60 | (薄膜)2956, 2923, 1707, 1632, 1594, 1549, 1372, 1247, 1114 | 對於C23 H31 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為367.2380;實測值為367.2385 | 1 H NMR(500 MHz, CDCl3 ) δ 7.79 (s, 1H), 7.43 (s, 1H), 7.36 - 7.31 (m, 2H), 7.18 (d,J = 7.8 Hz, 2H), 6.55 (s, 1H), 5.26 (s, 2H), 3.31 (s, 1H), 3.03 (s, 1H), 3.01 (s, 3H), 2.55 (s, 3H), 2.36 (s, 3H), 2.22 (s, 3H), 2.00 - 1.93 (m, 1H), 0.91 (d,J = 6.7 Hz, 6H)。 13 C NMR (126 MHz, CDCl3 ) δ 167.49, 154.64, 152.56, 139.55, 137.73, 133.67, 132.81, 129.18, 128.79, 128.29, 122.50, 122.11, 65.93, 61.17, 33.07, 27.25, 21.87, 21.21, 19.80, 17.45。 | |
61 | (薄膜)2970, 2927, 1707, 1629, 1592, 1549, 1371, 1250, 1110, 1047 | 對於C22 H29 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為353.2224;實測值為353.2227 | 1 H NMR(500 MHz, CDCl3 ) δ 7.79 (t,J = 1.4 Hz, 1H), 7.42 (s, 1H), 7.38 - 7.30 (m, 2H), 7.18 (dt,J = 6.6, 1.7 Hz, 2H), 6.55 (s, 1H), 5.26 (s, 2H), 3.40 (d,J = 94.6 Hz, 4H), 2.55 (s, 3H), 2.36 (s, 3H), 2.22 (s, 3H), 1.22 (t,J = 7.1 Hz, 6H)。 | |
62 | (薄膜)2922, 1708, 1637, 1596, 1550, 1367, 1249, 1098, 909, 734 | 對於C20 H25 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為325.1911;實測值為325.1914 | 1 H NMR(600 MHz, CDCl3 ) δ 7.78 (s, 1H), 7.43 (s, 1H), 7.34 (d,J = 8.0 Hz, 2H), 7.19 (d,J = 7.7 Hz, 2H), 6.56 (s, 1H), 5.26 (s, 2H), 3.03 (s, 6H), 2.54 (s, 3H), 2.36 (s, 3H), 2.22 (s, 3H)。 13 C NMR (151 MHz, CDCl3 ) δ 167.50, 154.43, 152.29, 139.54, 137.76, 133.66, 132.83, 129.19, 128.77, 128.31, 122.59, 121.99, 65.96, 39.99, 34.35, 21.86, 21.22, 17.39。 | |
63 | (薄膜)2926, 1709, 1641, 1599, 1370, 1254, 1155, 1114, 1086 | 對於C21 H24 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為393.1784;實測值為393.1791 | 1 H NMR(600 MHz, CDCl3 ) δ 7.78 (s, 1H), 7.44 (s, 1H), 7.34 (d,J = 7.9 Hz, 2H), 7.19 (d,J = 7.8 Hz, 2H), 6.56 (s, 1H), 5.27 (s, 2H), 4.17 (s, 1H), 3.77 (s, 1H), 3.15 (s, 3H), 2.55 (s, 3H), 2.36 (s, 3H), 2.20 (s, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 69.05, -71.73。 | |
64 | (薄膜)2921, 1707, 1631, 1594, 1549, 1370, 1248, 1132, 1085 | 對於C22 H27 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為351.2067;實測值為351.2073 | 1 H NMR(600 MHz, CDCl3 ) δ 7.78 (s, 1H), 7.49 - 7.46 (m, 1H), 7.36 - 7.32 (m, 2H), 7.21 - 7.16 (m, 2H), 6.57 (s, 1H), 5.84 (s, 1H), 5.26 (d,J = 9.9 Hz, 3H), 5.23 - 5.20 (m, 1H), 4.10 (s, 1H), 3.85 (s, 1H), 2.99 (s, 3H), 2.55 (s, 3H), 2.36 (s, 3H), 2.22 (s, 3H)。 | |
65 | (薄膜)2970, 1708, 1628, 1592, 1549, 1366, 1246, 1133, 1103 | 對於C22 H29 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為353.2224;實測值為353.2230 | 1 H NMR(600 MHz, CDCl3 ) δ 7.78 (s, 1H), 7.57 (d,J = 22.4 Hz, 1H), 7.36 - 7.31 (m, 2H), 7.21 - 7.16 (m, 2H), 6.58 (d,J = 17.8 Hz, 1H), 5.27 (d,J = 7.9 Hz, 2H), 4.34 (q,J = 7.1 Hz, 1H), 3.66 (s, 1H), 2.93 (s, 2H), 2.55 (s, 3H), 2.36 (s, 3H), 2.22 (s, 3H), 1.27 - 1.23 (m, 6H)。 | |
66 | (薄膜)2923, 1709, 1632, 1595, 1340, 1252, 1135, 1052 | 對於C22 H27 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為351.2067;實測值為351.2072 | 1 H NMR(600 MHz, CDCl3 ) δ 7.78 (d,J = 0.9 Hz, 1H), 7.61 (s, 1H), 7.37 - 7.31 (m, 2H), 7.22 - 7.16 (m, 2H), 6.55 (s, 1H), 5.26 (s, 2H), 3.04 (s, 3H), 2.71 (ddd,J = 10.5, 6.8, 3.8 Hz, 1H), 2.55 (s, 3H), 2.36 (s, 3H), 2.21 (s, 3H), 0.80 - 0.75 (m, 2H), 0.72 (dddd,J = 6.8, 4.5, 3.7, 0.8 Hz, 2H)。 | |
67 | (薄膜)2928, 1707, 1627, 1591, 1549, 1245, 1128, 1071 | 對於C25 H33 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為393.2537;實測值為393.2541 | 1 H NMR(600 MHz, CDCl3 ) δ 7.78 (d,J = 0.9 Hz, 1H), 7.57 (s, 1H), 7.37 - 7.30 (m, 2H), 7.22 - 7.14 (m, 2H), 6.56 (s, 1H), 5.26 (s, 2H), 3.16 (s, 1H), 3.05 - 2.82 (m, 3H), 2.55 (s, 3H), 2.36 (s, 3H), 2.22 (s, 3H), 1.84 (t,J = 15.8 Hz, 4H), 1.74 - 1.62 (m, 1H), 1.55 (d,J = 33.6 Hz, 3H), 1.33 (d,J = 13.5 Hz, 1H), 1.13 (qt,J = 13.1, 3.5 Hz, 1H)。 13 C NMR (151 MHz, CDCl3 ) δ 167.54, 154.88, 151.83, 139.55, 137.74, 133.70, 132.82, 129.19, 128.81, 128.31, 122.32, 121.94, 65.93, 61.73, 31.72, 29.50, 25.76, 25.38, 21.88, 21.22, 17.46。 | |
68 | (薄膜)2970, 2871, 1707, 1629, 1591, 1548, 1366, 1253, 1125 | 對於C22 H27 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為351.2067;實測值為351.2072 | 1 H NMR(600 MHz, CDCl3 ) δ 7.78 (d,J = 0.9 Hz, 1H), 7.67 (s, 1H), 7.37 - 7.32 (m, 2H), 7.21 - 7.15 (m, 2H), 6.57 (s, 1H), 5.26 (s, 2H), 3.59 - 3.46 (m, 4H), 2.54 (s, 3H), 2.36 (s, 3H), 2.23 (s, 3H), 1.96 (s, 4H)。 13 C NMR (151 MHz, CDCl3 ) δ 167.52, 154.81, 149.43, 139.53, 137.74, 133.66, 132.82, 129.18, 128.71, 128.31, 122.49, 122.14, 65.94, 48.62, 45.29, 24.93, 21.87, 21.21, 17.38。 | |
69 | (薄膜)2936, 2854, 1708, 1630, 1592, 1549, 1447, 1372, 1243, 1138, 1113 | 對於C23 H29 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為365.2224;實測值為365.2228 | 1 H NMR(600 MHz, CDCl3 ) δ 7.78 (d,J = 0.9 Hz, 1H), 7.41 (s, 1H), 7.37 - 7.32 (m, 2H), 7.22 - 7.16 (m, 2H), 6.57 (s, 1H), 5.26 (s, 2H), 3.70 - 3.28 (m, 1H), 2.55 (s, 3H), 2.36 (s, 3H), 2.21 (s, 3H), 1.74 - 1.65 (m, 2H), 1.65 - 1.58 (m, 4H), 1.56 (s, 3H)。 | |
70 | (薄膜)2920, 2853, 1706, 1629, 1593, 1550, 1436, 1373, 1230, 1128, 1112, 1023 | 對於C22 H27 N2 O3 計算的HRMS-ESI (m/z ) [M+H]+ 為367.2016;實測值為367.2020 | 1 H NMR(600 MHz, CDCl3 ) δ 7.78 (s, 1H), 7.44 (s, 1H), 7.37 - 7.31 (m, 2H), 7.19 (d,J = 7.8 Hz, 2H), 6.58 (s, 1H), 5.27 (s, 2H), 3.75 (dd,J = 5.6, 4.2 Hz, 4H), 3.54 (s, 4H), 2.55 (s, 3H), 2.36 (s, 3H), 2.20 (s, 3H)。 | |
71 | (薄膜)2923, 1709, 1630, 1586, 1553, 1495, 1349, 1251, 1132, 1049 | 對於C25 H27 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為387.2067;實測值為387.2073 | 1 H NMR(600 MHz, CDCl3 ) δ 8.01 (s, 1H), 7.82 (d,J = 0.9 Hz, 1H), 7.43 - 7.32 (m, 4H), 7.22 - 7.13 (m, 5H), 6.64 (s, 1H), 5.28 (s, 2H), 3.52 (s, 3H), 2.55 (s, 3H), 2.36 (s, 3H), 2.28 (s, 3H)。 13 C NMR (151 MHz, CDCl3 ) δ 167.42, 153.73, 150.06, 144.90, 139.59, 137.83, 133.56, 132.91, 129.51, 129.21, 128.83, 128.34, 124.27, 123.61, 122.09, 119.86, 66.08, 33.99, 21.79, 21.22, 17.45。 | |
72 | (薄膜)2921, 1709, 1633, 1594, 1550, 1371, 1251, 1131, 1088, 737 | 對於C26 H29 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為401.2224;實測值為401.2226 | 1 H NMR(600 MHz, CDCl3 ) δ 7.80 (s, 1H), 7.62 (d,J = 65.8 Hz, 1H), 7.44 - 7.28 (m, 7H), 7.19 (d,J = 7.8 Hz, 2H), 6.62 (s, 1H), 5.27 (s, 2H), 4.72 (s, 1H), 4.43 (s, 1H), 2.96 (s, 3H), 2.56 (s, 3H), 2.36 (s, 3H), 2.24 (s, 3H)。 | |
73 | (薄膜)3226, 2925, 1710, 1517, 1324, 1256, 1140, 1051, 908, 808, 729 | 對於C21 H27 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為371.1788;實測值為371.1792 | 1 H NMR(400 MHz, CDCl3 ) δ 7.82 (s, 1H), 7.36 - 7.30 (m, 2H), 7.19 (d,J = 7.8 Hz, 2H), 7.09 (s, 1H), 6.74 (s, 1H), 5.28 (s, 2H), 3.86 (q,J = 7.2 Hz, 2H), 3.21 (s, 3H), 2.54 (s, 3H), 2.36 (s, 3H), 2.23 (s, 3H), 1.29 (t,J = 7.2 Hz, 3H)。 13 C NMR (101 MHz, CDCl3 ) δ 182.03, 166.93, 141.63, 139.11, 138.03, 133.38, 133.19, 129.92, 129.27, 128.52, 128.41, 126.85, 66.45, 48.96, 38.43, 21.59, 21.22, 17.52, 12.05。 | |
74 | (薄膜)3240, 2974, 1713, 1516, 1258, 1141, 1055, 806, 728 | 對於C22 H29 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為385.1944;實測值為385.1950 | 1 H NMR(400 MHz, CDCl3 ) δ 7.81 (s, 1H), 7.36 - 7.28 (m, 2H), 7.23 - 7.15 (m, 3H), 6.75 (s, 1H), 5.27 (s, 2H), 3.76 (q,J = 7.1 Hz, 4H), 2.54 (s, 3H), 2.36 (s, 3H), 2.23 (s, 3H), 1.31 (t,J = 7.1 Hz, 6H)。 13 C NMR (101 MHz, CDCl3 ) δ 180.90, 167.00, 141.68, 138.92, 138.00, 133.26, 133.19, 130.80, 129.63, 129.26, 128.37, 127.11, 66.42, 45.82, 21.54, 21.21, 17.59, 12.70。 | |
75 | (薄膜)3236, 2970, 1716, 1526, 1371, 1330, 1216, 1144, 1055, 733 | 對於C20 H25 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為357.1631;實測值為357.1634 | 1 H NMR(400 MHz, CDCl3 ) δ 7.80 (s, 1H), 7.36 - 7.28 (m, 2H), 7.19 (d,J = 7.8 Hz, 2H), 7.03 (s, 1H), 6.84 (s, 1H), 5.27 (s, 2H), 3.30 (s, 6H), 2.53 (s, 3H), 2.36 (s, 3H), 2.22 (s, 3H)。 13 C NMR (101 MHz, CDCl3 ) δ 182.78, 166.94, 141.64, 139.08, 138.03, 133.37, 133.15, 129.78, 129.26, 128.39, 128.24, 126.80, 66.45, 41.71, 21.59, 21.21, 17.51。 | |
76 | (薄膜)3243, 2958, 1716, 1517, 1328, 1249, 1144, 1054, 733 | 對於C23 H31 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為399.2101;實測值為399.2107 | 1 H NMR(400 MHz, CDCl3 ) δ 7.81 (s, 1H), 7.36 - 7.28 (m, 2H), 7.19 (d,J = 7.8 Hz, 2H), 7.11 (s, 1H), 6.80 (s, 1H), 5.27 (s, 2H), 3.58 (d,J = 7.4 Hz, 2H), 3.27 (s, 3H), 2.53 (s, 3H), 2.36 (s, 3H), 2.28 - 2.11 (m, 4H), 0.99 (d,J = 6.7 Hz, 6H)。 13 C NMR (101 MHz, CDCl3 ) δ 182.72, 166.97, 141.72, 139.01, 138.01, 133.33, 133.17, 130.31, 129.26, 128.96, 128.38, 126.94, 66.43, 61.40, 40.46, 27.64, 21.56, 21.21, 20.20, 17.58。 | |
77 | (薄膜)3321, 2970, 1715, 1513, 1346, 1261, 1144, 736 | 對於C21 H24 F3 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為425.1505;實測值為425.1509 | 1 H NMR(400 MHz, CDCl3 ) δ 7.79 (s, 1H), 7.37 - 7.28 (m, 2H), 7.19 (d,J = 7.8 Hz, 2H), 7.14 (s, 1H), 7.10 (s, 1H), 5.27 (s, 2H), 4.71 (q,J = 8.8 Hz, 2H), 3.31 (s, 3H), 2.52 (s, 3H), 2.36 (s, 3H), 2.21 (s, 3H)。 13 C NMR (101 MHz, CDCl3 ) δ 185.02, 166.99, 140.94, 139.06, 138.12, 133.34, 133.04, 131.08, 129.67, 129.30, 128.43, 127.98, 124.47 (q,J = 281.6 Hz), 66.60, 54.39 (q,J = 33.4 Hz), 39.31, 21.41, 21.21, 17.41。 19 F NMR (376 MHz, CDCl3 ) δ - 69.18。 | |
78 | (薄膜)3240, 2924, 1714, 1517, 1328, 1232, 1143, 1053, 916, 806, 736 | 對於C22 H27 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為383.1788;實測值為383.1791 | 1 H NMR(400 MHz, CDCl3 ) δ 7.81 (s, 1H), 7.36 - 7.29 (m, 2H), 7.19 (d,J = 8.4 Hz, 3H), 6.88 (s, 1H), 5.92 (ddt,J = 17.2, 10.3, 5.1 Hz, 1H), 5.40 - 5.23 (m, 4H), 4.38 (d,J = 5.1 Hz, 2H), 3.30 (s, 3H), 2.54 (s, 3H), 2.36 (s, 3H), 2.20 (s, 3H)。 13 C NMR (101 MHz, CDCl3 ) δ 182.61, 166.94, 141.54, 138.94, 138.00, 133.31, 133.18, 131.62, 130.25, 129.26, 129.23, 128.38, 127.02, 117.96, 66.43, 56.01, 39.62, 21.57, 21.21, 17.61。 | |
79 | (薄膜)3228, 2971, 1714, 1510, 1312, 1248, 1143, 1114, 1056, 807, 733 | 對於C22 H29 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為385.1944;實測值為385.1950 | 1 H NMR(400 MHz, CDCl3 ) δ 7.81 (s, 1H), 7.36 - 7.30 (m, 2H), 7.19 (d,J = 7.8 Hz, 2H), 7.02 (s, 1H), 6.76 (s, 1H), 5.37 (s, 1H), 5.27 (s, 2H), 2.95 (s, 3H), 2.53 (s, 3H), 2.36 (s, 3H), 2.22 (s, 3H), 1.23 (d,J = 6.7 Hz, 6H)。 13 C NMR (101 MHz, CDCl3 ) δ 182.45, 166.92, 141.78, 139.12, 138.02, 133.41, 133.18, 129.52, 129.26, 128.40, 127.88, 126.58, 66.43, 52.27, 31.56, 21.58, 21.21, 19.40, 17.49。 | |
80 | (薄膜)3386, 2924, 1713, 1511, 1337, 1249, 1147, 1088, 1046, 731 | 對於C22 H27 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為383.1788;實測值為383.1795 | 1 H NMR(400 MHz, CDCl3 ) δ 7.84 (s, 1H), 7.81 (s, 1H), 7.41 (s, 1H), 7.37 - 7.31 (m, 2H), 7.19 (d,J = 7.8 Hz, 2H), 5.28 (s, 2H), 3.44 (s, 3H), 2.83 - 2.70 (m, 1H), 2.56 (s, 3H), 2.36 (s, 3H), 2.26 (s, 3H), 1.12 - 1.02 (m, 2H), 1.02 - 0.93 (m, 2H)。 13 C NMR (101 MHz, CDCl3 ) δ 182.90, 166.94, 141.23, 138.83, 137.99, 133.19, 133.16, 130.91, 130.29, 129.25, 128.36, 127.37, 66.42, 40.99, 31.52, 21.57, 21.21, 17.74, 9.35。 | |
81 | (薄膜)3225, 2926, 1713, 1508, 1242, 1142, 1053, 910, 731 | 對於C25 H33 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為425.2257;實測值為425.2263 | 1 H NMR(400 MHz, CDCl3 ) δ 7.81 (s, 1H), 7.35 - 7.28 (m, 2H), 7.19 (d,J = 7.8 Hz, 2H), 7.02 (s, 1H), 6.77 (s, 1H), 5.27 (s, 2H), 4.91 (s, 1H), 2.97 (s, 3H), 2.53 (s, 3H), 2.36 (s, 3H), 2.21 (s, 3H), 1.93 - 1.76 (m, 4H), 1.76 - 1.63 (m, 1H), 1.50 - 1.32 (m, 4H), 1.11 (dtt,J = 12.7, 9.2, 3.5 Hz, 1H)。 13 C NMR (101 MHz, CDCl3 ) δ 182.53, 166.92, 141.84, 139.13, 138.02, 133.41, 133.19, 129.36, 129.26, 128.40, 127.70, 126.44, 66.42, 60.67, 33.08, 29.81, 25.53, 25.48, 21.59, 21.21, 17.49。 | |
82 | (薄膜)3217, 2970, 2872, 1713, 1518, 1342, 1292, 1235, 1131, 1054, 915, 732 | 對於C22 H27 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為383.1788;實測值為383.1793 | 1 H NMR(400 MHz, CDCl3 ) δ 7.80 (s, 1H), 7.37 - 7.29 (m, 2H), 7.19 (d,J = 7.8 Hz, 2H), 6.75 (s, 1H), 5.27 (s, 2H), 3.65 (d,J = 133.9 Hz, 4H), 2.54 (s, 3H), 2.36 (s, 3H), 2.24 (s, 3H), 2.15 - 1.83 (m, 5H)。 | |
83 | (薄膜)3201, 2935, 1714, 1515, 1232, 1147, 1052, 999, 910, 730 | 對於C23 H29 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為397.1944;實測值為397.1950 | 1 H NMR(400 MHz, CDCl3 ) δ 7.80 (s, 1H), 7.37 - 7.29 (m, 2H), 7.19 (d,J = 7.8 Hz, 2H), 6.88 (d,J = 6.2 Hz, 2H), 5.27 (s, 2H), 3.72 (t,J = 5.0 Hz, 4H), 2.53 (s, 3H), 2.36 (s, 3H), 2.21 (s, 3H), 1.78 - 1.56 (m, 6H)。 13 C NMR (101 MHz, CDCl3 ) δ 182.98, 166.85, 142.10, 139.35, 138.04, 133.58, 133.17, 129.26, 128.42, 127.59, 125.80, 125.56, 66.43, 51.12, 25.45, 24.05, 21.66, 21.21, 17.39。 | |
84 | (薄膜)3218, 2969, 2856, 1713, 1515, 1228, 1114, 1028, 911, 731 | 對於C22 H27 N2 O3 S計算的HRMS-ESI (m/z ) [M+H]+ 為399.1737;實測值為399.1741 | 1 H NMR(400 MHz, CDCl3 ) δ 7.79 (s, 1H), 7.37 - 7.28 (m, 2H), 7.19 (d,J = 7.8 Hz, 2H), 7.01 (s, 1H), 6.91 (s, 1H), 5.27 (s, 2H), 3.87 - 3.63 (m, 8H), 2.53 (s, 3H), 2.36 (s, 3H), 2.21 (s, 3H)。 13 C NMR (101 MHz, CDCl3 ) δ 184.00, 166.81, 141.57, 139.37, 138.11, 133.66, 133.07, 129.29, 128.44, 128.16, 126.48, 126.12, 66.54, 66.06, 49.86, 21.61, 21.21, 17.39。 | |
85 | (薄膜)3379, 2924, 1712, 1491, 1339, 1249, 1090, 1041, 910, 731, 701 | 對於C25 H27 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為419.1788;實測值為419.1792 | 1 H NMR(400 MHz, CDCl3 ) δ 7.75 (s, 1H), 7.53 (dd,J = 8.3, 7.1 Hz, 2H), 7.46 - 7.39 (m, 2H), 7.38 - 7.33 (m, 2H), 7.33 - 7.28 (m, 2H), 7.18 (d,J = 7.8 Hz, 2H), 6.74 (s, 1H), 5.25 (s, 2H), 3.74 (s, 3H), 2.54 (s, 3H), 2.35 (s, 3H), 2.05 (s, 3H)。 | |
86 | (薄膜)3328, 2923, 1713, 1515, 1329, 1251, 1209, 1142, 1054, 910, 733 | 對於C26 H29 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為433.1944;實測值為433.1950 | 1 H NMR(400 MHz, CDCl3 ) δ 7.77 (s, 1H), 7.43 - 7.35 (m, 2H), 7.35 - 7.28 (m, 5H), 7.18 (d,J = 7.8 Hz, 2H), 7.12 (s, 1H), 6.87 (s, 1H), 5.25 (s, 2H), 5.04 (s, 2H), 3.29 (s, 3H), 2.50 (s, 3H), 2.35 (s, 3H), 2.07 (s, 3H)。 | |
87 | (薄膜)2930, 1705, 1631, 1581, 1370, 1264, 1165, 1089, 774 | 對於C19 H23 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為311.1754;實測值為311.1760 | 1 H NMR(500 MHz, CDCl3 ) δ 8.01 - 7.93 (m, 2H), 7.56 (d,J = 49.8 Hz, 1H), 7.33 (d,J = 7.9 Hz, 2H), 7.18 (d,J = 7.7 Hz, 2H), 6.95 (d,J = 8.1 Hz, 2H), 5.28 (s, 2H), 3.67 3.20 (m, 2H), 3.02 (s, 3H), 2.35 (s, 3H), 1.21 (t,J = 7.1 Hz, 3H)。 13 C NMR (126 MHz, CDCl3 ) δ 166.69, 156.72, 153.18, 137.87, 133.42, 131.03, 129.20, 128.28, 123.79, 120.85, 66.23, 48.14, 32.20, 21.21, 14.31。 | |
88 | (薄膜)2934, 1710, 1633, 1577, 1369, 1233, 1112, 1070 | 對於C20 H25 N2 O3 計算的HRMS-ESI (m/z ) [M+H]+ 為341.1860;實測值為341.1864 | 1 H NMR(500 MHz, CDCl3 ) δ 7.81 (d,J = 8.4 Hz, 1H), 7.63 (s, 1H), 7.34 (d,J = 7.8 Hz, 2H), 7.17 (d,J = 7.7 Hz, 2H), 6.58 (s, 1H), 6.53 - 6.44 (m, 1H), 5.27 (s, 2H), 3.90 (s, 3H), 3.65 - 3.20 (m, 2H), 3.02 (s, 2H), 2.35 (s, 3H), 2.16 (s, 1H), 1.22 (t,J = 7.2 Hz, 3H)。 13 C NMR (126 MHz, CDCl3 ) δ 165.69, 161.11, 157.87, 153.23, 137.63, 133.67, 133.26, 129.12, 128.19, 111.81, 105.82, 65.94, 55.86, 48.19, 32.22, 30.92, 21.20, 14.30。 | |
89 | (薄膜)2920, 1706, 1639, 1592, 1297, 1180, 1111, 772 | 對於C21 H27 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為339.2067;實測值為339.2072 | 1 H NMR(500 MHz, CDCl3 ) δ 7.72 (s, 2H), 7.38 - 7.32 (m, 2H), 7.19 (d,J = 7.7 Hz, 2H), 7.15 (s, 1H), 5.28 (s, 2H), 3.66 - 3.13 (m, 1H), 3.00 (s, 3H), 2.36 (s, 3H), 2.15 (s, 6H), 1.62 (s, 1H), 1.21 (t,J = 7.1 Hz, 3H)。 | |
90 | (薄膜)2934, 1718, 1632, 1577, 1372, 1226, 1083 | 對於C20 H24 ClN2 O3 計算的HRMS-ESI (m/z ) [M+H]+ 為375.1470;實測值為375.1477 | 1 H NMR(500 MHz, CDCl3 ) δ 7.89 (s, 1H), 7.49 (d,J = 62.9 Hz, 1H), 7.38 - 7.31 (m, 2H), 7.18 (d,J = 7.8 Hz, 2H), 6.44 (d,J = 15.7 Hz, 1H), 5.26 (s, 2H), 3.88 (s, 3H), 3.45 (dq,J = 108.8, 7.1 Hz, 2H), 3.04 (d,J = 14.1 Hz, 3H), 2.35 (s, 3H), 1.24 (t,J = 7.2 Hz, 3H)。 | |
91 | (薄膜)2974, 2924, 1703, 1632, 1593, 1548, 1368, 1246, 1108, 1059, 816 | 對於C22 H29 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為353.2224;實測值為353.2229 | 1 H NMR(500 MHz, CDCl3 ) δ 7.79 (s, 1H), 7.54 - 7.36 (m, 1H), 7.36 - 7.30 (m, 2H), 7.16 (d,J = 7.9 Hz, 2H), 6.55 (s, 1H), 6.05 (q,J = 6.6 Hz, 1H), 3.41 (d,J = 90.5 Hz, 2H), 3.01 (s, 3H), 2.53 (s, 3H), 2.34 (s, 3H), 2.24 (s, 3H), 1.63 (d,J = 6.6 Hz, 3H), 1.21 (t,J = 7.2 Hz, 3H)。 | |
92 | (薄膜)2974, 2924, 1704, 1632, 1593, 1548, 1369, 1246, 1142, 1109, 1060, 816 | 對於C22 H29 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為353.2224;實測值為353.2230 | 1 H NMR(500 MHz, CDCl3 ) δ 7.80 (s, 1H), 7.46 (t,J = 10.0 Hz, 1H), 7.36 - 7.30 (m, 2H), 7.16 (d,J = 7.8 Hz, 2H), 6.55 (s, 1H), 6.05 (q,J = 6.6 Hz, 1H), 3.40 (d,J = 93.0 Hz, 2H), 3.00 (s, 3H), 2.53 (s, 3H), 2.33 (s, 3H), 2.25 (s, 3H), 1.63 (d,J = 6.6 Hz, 3H), 1.21 (t,J = 7.1 Hz, 3H)。 | |
93 | (薄膜)2925, 1706, 1631, 1581, 1368, 1243, 1112, 1068, 778 | 對於C20 H25 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為325.1911;實測值為325.1915 | 1 H NMR(500 MHz, CDCl3 ) δ 7.91 (d,J = 8.1 Hz, 1H), 7.37 - 7.28 (m, 2H), 7.18 (d,J = 7.7 Hz, 2H), 6.78 (d,J = 8.2 Hz, 2H), 5.26 (s, 2H), 3.58 - 3.22 (m, 2H), 3.01 (s, 3H), 2.58 (s, 3H), 2.35 (s, 3H), 1.28 - 1.14 (m, 4H)。 | |
94 | (薄膜)2932, 1722, 1627, 1564, 1370, 1229, 1109, 1074, 807, 775 | 對於C19 H21 Cl2 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為379.0975;實測值為379.0979 | 1 H NMR(500 MHz, CDCl3 ) δ 7.94 (d,J = 2.2 Hz, 1H), 7.51 (d,J = 63.1 Hz, 1H), 7.39 - 7.32 (m, 2H), 7.19 (d,J = 7.8 Hz, 2H), 6.91 (d,J = 11.7 Hz, 1H), 5.29 (s, 2H), 3.46 (dq,J = 104.7, 7.2 Hz, 2H), 3.05 (d,J = 13.3 Hz, 3H), 2.36 (s, 3H), 1.24 (dt,J = 12.1, 7.1 Hz, 3H)。 | |
95 | (薄膜)2933, 1704, 1630, 1577, 1371, 1261, 1221, 1107, 1033, 968, 807, 766 | 對於C20 H25 N2 O3 計算的HRMS-ESI (m/z ) [M+H]+ 為341.1860;實測值為341.1864 | 1 H NMR(500 MHz, CDCl3 ) δ 7.62 (dd,J = 8.1, 1.9 Hz, 1H), 7.54 (d,J = 1.9 Hz, 1H), 7.36 - 7.32 (m, 2H), 7.19 (d,J = 7.7 Hz, 2H), 6.80 (d,J = 8.2 Hz, 1H), 5.30 (s, 2H), 3.87 (s, 3H), 3.67 - 3.50 (m, 1H), 3.31 (q,J = 7.3 Hz, 2H), 3.03 (d,J = 32.5 Hz, 3H), 2.36 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 | |
96 | (薄膜)2920, 1704, 1631, 1586, 1368, 1255, 1178, 1106, 806, 771 | 對於C20 H25 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為325.1911;實測值為325.1916 | 1 H NMR(500 MHz, CDCl3 ) δ 7.85 (d,J = 2.0 Hz, 1H), 7.81 (dd,J = 8.2, 2.1 Hz, 1H), 7.48 (s, 1H), 7.37 - 7.30 (m, 2H), 7.18 (d,J = 7.7 Hz, 2H), 6.74 (d,J = 8.2 Hz, 1H), 5.28 (s, 2H), 3.41 (d,J = 106.9 Hz, 2H), 3.01 (s, 3H), 2.35 (s, 3H), 2.28 (s, 3H), 1.21 (t,J = 7.1 Hz, 3H)。 | |
97 | (薄膜)2923, 1707, 1628, 1573, 1365, 1248, 1140, 1062, 968, 805, 778 | 對於C21 H27 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為339.2067;實測值為339.2071 | 1 H NMR(500 MHz, CDCl3 ) δ 7.67 (d,J = 8.3 Hz, 1H), 7.41 (s, 1H), 7.36 - 7.29 (m, 2H), 7.17 (d,J = 7.9 Hz, 2H), 6.59 (d,J = 8.4 Hz, 1H), 5.26 (s, 2H), 3.40 (d,J = 104.0 Hz, 2H), 3.00 (s, 3H), 2.51 (s, 3H), 2.35 (s, 3H), 2.27 (s, 3H), 1.20 (t,J = 7.1 Hz, 3H)。 | |
98 | (薄膜)2969, 2924, 1704, 1631, 1592, 1547, 1367, 1244, 1108, 1083, 1044, 813, 781 | 對於C23 H31 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為367.2380;實測值為367.2386 | 1 H NMR(500 MHz, CDCl3 ) δ 7.81 (s, 1H), 7.46 (s, 1H), 7.35 - 7.28 (m, 2H), 7.15 (d,J = 7.8 Hz, 2H), 6.55 (s, 1H), 5.83 (t,J = 6.8 Hz, 1H), 3.41 (d,J = 90.3 Hz, 2H), 3.01 (s, 3H), 2.53 (s, 3H), 2.33 (s, 3H), 2.25 (s, 3H), 2.11 - 1.98 (m, 1H), 1.91 (ddd,J = 13.9, 7.6, 6.5 Hz, 1H), 1.21 (t,J = 7.1 Hz, 3H), 0.95 (t,J = 7.4 Hz, 3H)。 | |
99 | (薄膜)2922, 1706, 1631, 1591, 1546, 1242, 1106, 1085, 1042, 730, 697 | 對於C27 H31 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為415.2380;實測值為415.2385 | 1 H NMR(500 MHz, CDCl3 ) δ 7.90 (s, 1H), 7.53 - 7.38 (m, 3H), 7.38 - 7.28 (m, 4H), 7.28 - 7.23 (m, 1H), 7.15 (d,J = 7.8 Hz, 2H), 7.05 (s, 1H), 6.56 (s, 1H), 3.41 (d,J = 96.5 Hz, 2H), 3.00 (s, 3H), 2.55 (s, 3H), 2.32 (s, 3H), 2.26 (s, 3H), 1.21 (t,J = 7.1 Hz, 3H)。 | |
100 | (薄膜)2925, 1707, 1632, 1592, 1547, 1244, 1130, 1107, 817, 732 | 對於C24 H30 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為435.2254;實測值為435.2261 | 1 H NMR(500 MHz, CDCl3 ) δ 7.80 (s, 1H), 7.57 - 7.35 (m, 1H), 7.34 - 7.27 (m, 2H), 7.17 (d,J = 7.9 Hz, 2H), 6.56 (s, 1H), 5.95 (dd,J = 7.9, 4.9 Hz, 1H), 3.42 (d,J = 96.3 Hz, 2H), 3.01 (s, 3H), 2.53 (s, 3H), 2.34 (s, 3H), 2.32 - 2.08 (m, 7H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 66.29 (t,J = 10.3 Hz)。 | |
101 | (薄膜)2922, 1704, 1631, 1591, 1547, 1367, 1244, 1007, 730, 699 | 對於C28 H33 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為429.2537;實測值為429.2544 | 1 H NMR(500 MHz, CDCl3 ) δ 7.76 (s, 1H), 7.58 - 7.33 (m, 1H), 7.26 - 7.19 (m, 5H), 7.19 - 7.13 (m, 4H), 7.11 (d,J = 7.9 Hz, 2H), 6.52 (s, 1H), 6.11 (dd,J = 7.6, 6.2 Hz, 1H), 3.32 (dd,J = 13.7, 7.6 Hz, 1H), 3.15 (dd,J = 13.7, 6.2 Hz, 1H), 3.00 (s, 3H), 2.46 (s, 3H), 2.32 (s, 3H), 2.24 (s, 3H), 1.21 (t,J = 7.2 Hz, 3H)。 | |
102 | (薄膜)2974, 2927, 1703, 1632, 1580, 1243, 1112, 1059, 815, 778 | 對於C21 H27 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為339.2067;實測值為339.2074 | 1 H NMR(500 MHz, CDCl3 ) δ 7.93 (d,J = 8.2 Hz, 1H), 7.60 (s, 1H), 7.37 - 7.30 (m, 2H), 7.16 (d,J = 7.8 Hz, 2H), 6.80 (d,J = 9.4 Hz, 2H), 6.05 (q,J = 6.6 Hz, 1H), 3.64 - 3.18 (m, 2H), 3.01 (s, 3H), 2.58 (s, 3H), 2.33 (s, 3H), 1.63 (d,J = 6.6 Hz, 3H), 1.21 (t,J = 7.1 Hz, 3H)。 | |
103 | (薄膜)2975, 2929, 1702, 1631, 1587, 1255, 1108, 1058, 815, 771 | 對於C21 H27 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為339.2067;實測值為339.2074 | 1 H NMR(500 MHz, CDCl3 ) δ 7.85 (d,J = 2.0 Hz, 1H), 7.81 (dd,J = 8.1, 2.1 Hz, 1H), 7.49 (d,J = 10.2 Hz, 1H), 7.38 - 7.30 (m, 2H), 7.16 (d,J = 7.8 Hz, 2H), 6.74 (d,J = 8.2 Hz, 1H), 6.07 (q,J = 6.6 Hz, 1H), 3.42 (d,J = 104.4 Hz, 2H), 3.02 (s, 3H), 2.33 (s, 3H), 2.29 (s, 3H), 1.63 (d,J = 6.7 Hz, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 | |
104 | ESIMSm/z 351 [(M+H)+ ] | 1 H NMR(600 MHz, CDCl3 ) δ 7.79 (s, 1H), 7.34 (d,J = 7.8 Hz, 2H), 7.19 (d,J = 7.8 Hz, 2H), 6.63 (s, 1H), 5.27 (s, 2H), 4.39 (s, 1H), 3.22 (d,J = 100.6 Hz, 2H), 2.59 (d,J = 31.6 Hz, 2H), 2.52 (s, 3H), 2.36 (s, 3H), 2.07 (s, 3H), 1.76 (dh,J = 8.3, 4.0, 3.3 Hz, 4H)。 13 C NMR (151 MHz, CDCl3 ) δ 167.43, 155.09, 152.08, 139.70, 137.84, 133.52, 133.42, 129.21, 128.35, 127.29, 125.05, 123.33, 66.08, 42.55, 30.85, 23.06, 21.70, 21.22, 21.14, 17.02。 | ||
105 | ESIMSm/z 351 ([M+H]+ ) | 1 H NMR(400 MHz, CDCl3 ) δ 7.77 (s, 1H), 7.44-7.41 (m, 1H), 7.28-7.19 (m, 3H), 6.56 (s, 1H), 5.31 (s, 2H), 3.37 (t,J = 6.8 Hz, 2H), 2.97 (s, 3H), 2.52 (s, 3H), 2.41 (s, 3H), 2.22 (t,J = 8.0 Hz, 2H), 2.09 (s, 3H), 1.97-1.89 (m, 2H) 13 C NMR (101 MHz, CDCl3 ) δ 167.51, 161.12, 155.64, 139.28, 136.98, 134.60, 132.87, 130.30, 129.22, 128.26, 127.49, 125.98, 124.91, 122.09, 64.39, 51.28, 31.28, 27.65, 21.81, 19.73, 19.05, 17.48 | ||
106 | 69-73 | ESIMSm/z 366 ([M+H]+ ) | 1 H NMR(300 MHz, CDCl3 ) δ 7.77 (s, 1H), 7.44-7.41 (m, 1H), 7.24-7.20 (m, 3H), 6.49 (s, 1H), 5.31 (s, 2H), 3.26 (t,J = 6.0 Hz, 2H), 3.01 (s, 3H), 2.52 (s, 3H), 2.41 (s, 3H), 2.08 (t,J = 6.3 Hz, 2H), 2.04 (s, 3H), 1.82-1.76 (m, 2H) 1.66-1.60 (m, 2H) 13 C NMR (75 MHz, CDCl3 ) δ 167.45, 156.13, 154.43, 139.35, 136.94, 134.59, 132.91, 130.25, 129.16, 128.20, 126.89, 125.94, 124.99, 121.78, 64.33, 50.62, 37.22, 26.99, 23.67, 21.78, 21.37, 19.01, 17.47 | |
107 | ESIMSm/z 353 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.66 (s, 1H), 7.38 (d,J = 7.2 Hz, 1H), 7.27-7.19 (m, 3H), 6.42 (s, 1H), 5.27 (s, 2H), 3.44-3.39 (q,J = 6.8 Hz, 2H), 2.94 (s, 3H), 2.42 (s, 3H), 2.36 (s, 3H), 1.95 (s, 3H), 1.76 (s, 3H), 1.09 (t,J = 6.8 Hz, 3H) | ||
108 | 90-92 | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.67 (s, 1H), 7.38 (d,J = 6.8 Hz, 1H), 7.27-7.20 (m, 3H), 6.62 (s, 1H), 5.59-5.51 (m, 1H), 5.28 (s, 2H), 3.73 (s, 3H), 2.54 (d,J = 4.8 Hz, 3H), 2.43 (s, 3H), 2.35 (s, 3H), 2.01 (s, 3H) | ||
109 | ESIMSm/z 379 ([M+H]+ ) | 1 H NMR(300 MHz, DMSO-d 6 , 90°C) δ 7.90 (s, 1H ), 7.79 (s, 1H), 7.39 (d,J = 6.9 Hz, 1H), 7.25 - 7.17 (m, 4H), 5.33 (s, 2H), 3.50-3.36 (m, 2H), 3.01 (s, 3H), 2.36 (s, 3H), 1.18 (t,J = 7.2 Hz, 3H) | ||
110 | ESIMSm/z 359 ([M+H]+ ) | 1 H NMR(300 MHz, DMSO-d 6 , 80°C) δ 7.79 (s, 1H), 7.60 (s, 1H), 7.39 (d,J = 6.9 Hz, 1H), 7.25-71.8 (m, 3H), 6.95 (s, 1H), 5.30 (s, 2H), 3.48-3.36 (m, 2H), 2.98 (s, 3H), 2.36 (s, 3H), 2.16 (s, 3H), 1.16 (t,J = 7.2 Hz, 3H) 13 C NMR (75 MHz, DMSO-d 6 ) δ 164.49, 155.13, 153.47, 136.65, 134.04, 132.56, 130.95, 130.14, 129.95, 129.01, 128.33, 125.88, 120.36, 119.64, 64.60, 47.08, 31.54, 18.50, 17.19, 13.98 | ||
111 | ESIMSm/z 359 ([M+H]+ ) | 1 H NMR(300 MHz, DMSO-d 6 , 80°C) δ 7.78 (brs, 2H), 7.34 (d,J = 7.2 Hz, 1H), 7.25 - 7.17 (m, 3H), 6.89 (s, 1H), 5.30 (s, 2H), 3.48-3.36 (m, 2H), 2.99 (s, 3H), 2.46 (s, 3H),2.36 (s, 3H), 1.17 (t,J = 7.2 Hz, 3H) | ||
112 | (薄膜)3239, 2972, 1713, 1520, 1327, 1260, 1142, 1052, 745 | 對於C21 H27 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為371.1788;實測值為371.1793 | 1 H NMR(600 MHz, CDCl3 ) δ 7.82 (s, 1H), 7.43 - 7.38 (m, 1H), 7.29 - 7.19 (m, 3H), 7.11 (s, 1H), 6.72 (s, 1H), 5.33 (s, 2H), 3.86 (q,J = 7.2 Hz, 2H), 3.22 (s, 3H), 2.55 (s, 3H), 2.41 (s, 3H), 2.24 (s, 3H), 1.30 (t,J = 7.1 Hz, 3H)。 13 C NMR (151 MHz, CDCl3 ) δ 181.89, 166.82, 141.63, 139.20, 137.01, 134.08, 133.35, 130.38, 129.96, 129.31, 128.60, 128.48, 126.68, 126.03, 64.87, 48.93, 38.40, 21.60, 19.01, 17.55, 12.05。 | |
113 | (薄膜)3240, 2973, 1712, 1515, 1257, 1139, 1051, 728 | 對於C22 H29 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為385.1944;實測值為385.1951 | 1 H NMR(600 MHz, CDCl3 ) δ 7.82 (s, 1H), 7.43 - 7.38 (m, 1H), 7.29 - 7.24 (m, 1H), 7.22 (d,J = 5.3 Hz, 3H), 6.72 (s, 1H), 5.33 (s, 2H), 3.77 (q,J = 7.1 Hz, 4H), 2.55 (s, 3H), 2.41 (s, 3H), 2.24 (s, 3H), 1.32 (t,J = 7.2 Hz, 6H)。 13 C NMR (151 MHz, CDCl3 ) δ 180.80, 166.87, 141.66, 139.06, 137.00, 134.09, 133.26, 130.77, 130.37, 129.66, 129.30, 128.47, 126.94, 126.03, 64.86, 45.81, 21.57, 19.01, 17.62, 12.69。 | |
114 | (薄膜)3227, 2972, 1712, 1508, 1310, 1247, 1142, 1056, 911, 732 | 對於C22 H29 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為385.1944;實測值為385.1950 | 1 H NMR(600 MHz, CDCl3 ) δ 7.82 (s, 1H), 7.43 - 7.38 (m, 1H), 7.26 (ddd,J = 8.0, 6.9, 1.5 Hz, 1H), 7.24 - 7.19 (m, 2H), 7.04 (s, 1H), 6.72 (s, 1H), 5.38 (s, 1H), 5.33 (s, 2H), 2.96 (s, 3H), 2.55 (s, 3H), 2.41 (s, 3H), 2.23 (s, 3H), 1.24 (d,J = 6.7 Hz, 6H)。 13 C NMR (151 MHz, CDCl3 ) δ 182.35, 166.81, 141.75, 139.25, 137.01, 134.08, 133.40, 130.38, 129.46, 129.32, 128.48, 127.86, 126.39, 126.03, 64.87, 52.28, 31.55, 21.60, 19.40, 19.01, 17.52。 | |
115 | (薄膜)3222, 2970, 1713, 1522, 1343, 1304, 1260, 1239, 1160, 1132, 734 | 對於C22 H27 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為383.1788;實測值為383.1791 | 1 H NMR(600 MHz, CDCl3 ) δ 7.82 (s, 1H), 7.43 - 7.38 (m, 1H), 7.30 (s, 1H), 7.29 - 7.24 (m, 1H), 7.24 - 7.19 (m, 2H), 6.68 (s, 1H), 5.33 (s, 2H), 3.69 (d,J = 248.1 Hz, 4H), 2.56 (s, 3H), 2.41 (s, 3H), 2.26 (s, 3H), 2.04 (s, 4H)。 | |
116 | (薄膜)3212, 2935, 1711, 1513, 1231, 1146, 908, 728 | 對於C23 H29 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為397.1944;實測值為397.1952 | 1 H NMR(600 MHz, CDCl3 ) δ 7.80 (s, 1H), 7.43 - 7.38 (m, 1H), 7.29 - 7.24 (m, 1H), 7.24 - 7.19 (m, 2H), 6.90 (s, 1H), 6.81 (s, 1H), 5.33 (s, 2H), 3.73 (t,J = 5.2 Hz, 4H), 2.54 (s, 3H), 2.41 (s, 3H), 2.22 (s, 3H), 1.65 (tt,J = 10.9, 4.2 Hz, 6H)。 13 C NMR (151 MHz, CDCl3 ) δ 182.94, 166.76, 142.09, 139.50, 137.01, 134.08, 133.57, 130.39, 129.33, 128.50, 127.37, 126.04, 125.56, 125.37, 64.86, 51.17, 25.44, 24.03, 21.69, 19.02, 17.41。 | |
117 | (薄膜)3227, 2929, 1713, 1519, 1328, 1123, 908, 729, 701 | 對於C21 H24 F3 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為425.1505;實測值為425.1516 | 1 H NMR(600 MHz, CDCl3 ) δ 7.84 (s, 1H), 7.70 (d,J = 1.8 Hz, 1H), 7.65 - 7.58 (m, 2H), 7.51 (t,J = 7.7 Hz, 1H), 7.13 (s, 1H), 6.74 (s, 1H), 5.36 (s, 2H), 3.87 (q,J = 7.2 Hz, 2H), 3.23 (s, 3H), 2.56 (s, 3H), 2.26 (s, 3H), 1.30 (t,J = 7.2 Hz, 3H)。 19 F NMR (564 MHz, CDCl3 ) δ - 62.65。 | |
118 | (薄膜)3238, 2976, 1716, 1517, 1329, 1258, 1126 | 對於C22 H26 F3 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為439.1662;實測值為439.1667 | 1 H NMR(600 MHz, CDCl3 ) δ 7.85 (s, 1H), 7.70 (s, 1H), 7.62 (dd,J = 15.7, 7.8 Hz, 2H), 7.51 (t,J = 7.7 Hz, 1H), 7.25 (s, 1H), 6.72 (s, 1H), 5.37 (s, 2H), 3.78 (q,J = 6.9 Hz, 4H), 2.56 (s, 3H), 2.26 (s, 3H), 1.33 (t,J = 7.2 Hz, 6H)。 19 F NMR (564 MHz, CDCl3 ) δ - 62.65。 | |
119 | (薄膜)3224, 2974, 1715, 1511, 1329, 1163, 1123 | 對於C22 H26 F3 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為439.1662;實測值為439.1669 | 1 H NMR(600 MHz, CDCl3 ) δ 7.84 (s, 1H), 7.70 (s, 1H), 7.62 (dd,J = 15.4, 7.8 Hz, 2H), 7.52 (t,J = 7.7 Hz, 1H), 7.07 (s, 1H), 6.72 (s, 1H), 5.37 (s, 2H), 2.98 (s, 3H), 2.55 (s, 3H), 2.25 (s, 3H), 1.56 (s, 1H), 1.24 (d,J = 6.7 Hz, 6H)。 19 F NMR (564 MHz, CDCl3 ) δ - 62.65。 | |
120 | (薄膜)3218, 2971, 1716, 1522, 1330, 1162, 1125, 734 | 對於C22 H24 F3 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為437.1505;實測值為437.1513 | 1 H NMR(600 MHz, CDCl3 ) δ 7.84 (s, 1H), 7.70 (s, 1H), 7.62 (dd,J = 14.9, 7.7 Hz, 2H), 7.51 (t,J = 7.7 Hz, 1H), 7.33 (s, 1H), 6.69 (s, 1H), 5.37 (s, 2H), 4.02 - 3.37 (m, 4H), 2.56 (s, 3H), 2.27 (s, 3H), 2.19 - 1.92 (m, 4H)。 19 F NMR (564 MHz, CDCl3 ) δ - 62.65。 | |
121 | (薄膜)3205, 2937, 1715, 1515, 1329, 1233, 1126, 730 | 對於C23 H26 F3 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為451.1662;實測值為451.1669 | 1 H NMR(600 MHz, CDCl3 ) δ 7.83 (s, 1H), 7.70 (s, 1H), 7.62 (dd,J = 14.8, 7.8 Hz, 2H), 7.52 (t,J = 7.7 Hz, 1H), 6.92 (s, 1H), 6.80 (s, 1H), 5.36 (s, 2H), 3.74 (t,J = 5.1 Hz, 4H), 2.55 (s, 3H), 2.24 (s, 3H), 1.66 (tt,J = 10.5, 4.3 Hz, 6H)。 19 F NMR (564 MHz, CDCl3 ) δ - 62.65。 | |
122 | (薄膜)2970, 2929, 1705, 1628, 1590, 1546, 1370, 1249, 1108, 742 | 對於C22 H29 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為353.2224;實測值為353.2227 | 1 H NMR(600 MHz, CDCl3 ) δ 7.78 (s, 1H), 7.43 (s, 2H), 7.28 - 7.18 (m, 3H), 6.56 (s, 1H), 5.31 (s, 2H), 3.50 (s, 2H), 3.30 (s, 2H), 2.55 (s, 3H), 2.41 (s, 3H), 2.22 (s, 3H), 1.22 (t,J = 7.1 Hz, 6H)。 13 C NMR (151 MHz, CDCl3 ) δ 167.44, 154.92, 151.08, 139.66, 136.94, 134.60, 132.74, 130.28, 129.12, 128.93, 128.22, 125.96, 122.19, 121.88, 64.38, 45.56, 39.77, 21.84, 19.02, 17.51。 | |
123 | (薄膜)2970, 2925, 1707, 1627, 1590, 1548, 1243, 1131, 1101, 1045, 741 | 對於C22 H29 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為353.2224;實測值為353.2229 | 1 H NMR(600 MHz, CDCl3 ) δ 7.79 (d,J = 4.9 Hz, 1H), 7.55 (s, 1H), 7.42 (dt,J = 7.1, 2.7 Hz, 1H), 7.29 - 7.18 (m, 3H), 6.59 (d,J = 21.5 Hz, 1H), 5.32 (d,J = 10.5 Hz, 3H), 3.89 (s, 1H), 3.66 (s, 1H), 2.92 (s, 2H), 2.55 (s, 3H), 2.41 (d,J = 2.1 Hz, 3H), 2.23 (s, 2H), 1.32 - 1.15 (m, 6H)。 | |
124 | (薄膜)2966, 2870, 1704, 1626, 1589, 1546, 1365, 1244, 1124, 740 | 對於C22 H27 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為351.2067;實測值為351.2073 | 1 H NMR(600 MHz, CDCl3 ) δ 7.78 (s, 1H), 7.67 (s, 1H), 7.44 - 7.40 (m, 1H), 7.28 - 7.18 (m, 3H), 6.58 (s, 1H), 5.31 (s, 2H), 3.54 - 3.49 (m, 4H), 2.55 (s, 3H), 2.41 (s, 3H), 2.24 (s, 3H), 1.95 (s, 4H)。 13 C NMR (151 MHz, CDCl3 ) δ 167.43, 154.86, 149.41, 139.61, 136.95, 134.58, 132.78, 130.28, 129.14, 128.75, 128.23, 125.96, 122.33, 122.16, 64.39, 48.69, 45.34, 21.85, 19.02, 17.41。 | |
125 | (薄膜)2934, 2853, 1705, 1627, 1590, 1546, 1369, 1240, 1110, 737 | 對於C23 H29 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為365.2224;實測值為365.2230 | 1 H NMR(600 MHz, CDCl3 ) δ 7.78 (s, 1H), 7.42 (d,J = 7.0 Hz, 2H), 7.28 - 7.18 (m, 3H), 6.58 (s, 1H), 5.31 (s, 2H), 3.47 (d,J = 141.0 Hz, 4H), 2.55 (s, 3H), 2.41 (s, 3H), 2.22 (s, 3H), 1.69 (pd,J = 5.6, 3.6 Hz, 2H), 1.65 1.59 (m, 4H)。 | |
126 | (薄膜)2972, 2932, 1708, 1629, 1590, 1547, 1329, 1250, 1109, 701 | 對於C22 H26 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為407.1941;實測值為407.1948 | 1 H NMR(600 MHz, CDCl3 ) δ 7.80 (d,J = 1.1 Hz, 1H), 7.72 - 7.68 (m, 1H), 7.64 (d,J = 7.7 Hz, 1H), 7.61 - 7.56 (m, 1H), 7.50 (t,J = 7.8 Hz, 1H), 7.44 (s, 1H), 6.57 (s, 1H), 5.35 (s, 2H), 3.41 (d,J = 120.6 Hz, 4H), 2.56 (s, 3H), 2.24 (s, 3H), 1.23 (t,J = 7.1 Hz, 6H)。 13 C NMR (151 MHz, CDCl3 ) δ 167.18, 155.18, 151.14, 139.82, 137.77, 132.77, 131.31, 130.92 (q,J = 32.3 Hz), 129.10, 129.04, 124.76 (dq,J = 7.5, 3.8 Hz, 2個碳), 124.05 (q,J = 272.3 Hz), 121.94, 121.77, 65.08, 45.49, 39.78, 21.87, 17.54。 19 F NMR (564 MHz, CDCl3 ) δ - 62.63。 | |
127 | (薄膜)2972, 1708, 1628, 1590, 1547, 1329, 1244, 1124, 1098, 701 | 對於C22 H26 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為407.1941;實測值為407.1948 | 1 H NMR(600 MHz, CDCl3 ) δ 7.81 (d,J = 5.8 Hz, 1H), 7.70 (s, 1H), 7.66 - 7.55 (m, 3H), 7.50 (t,J = 7.7 Hz, 1H), 6.58 (s, 1H), 5.36 (d,J = 9.1 Hz, 2H), 3.67 (s, 1H), 2.94 (s, 3H), 2.56 (s, 3H), 2.23 (d,J = 17.9 Hz, 3H), 1.26 (d,J = 6.6 Hz, 6H)。 19 F NMR (564 MHz, CDCl3 ) δ - 62.63。 | |
128 | (薄膜)2968, 2973, 1707, 1628, 1589, 1546, 1329, 1244, 1117, 701 | 對於C22 H24 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為405.1784;實測值為405.1791 | 1 H NMR(600 MHz, CDCl3 ) δ 7.80 (s, 1H), 7.69 (d,J = 12.7 Hz, 2H), 7.63 (d,J = 7.7 Hz, 1H), 7.58 (d,J = 7.8 Hz, 1H), 7.50 (t,J = 7.7 Hz, 1H), 6.59 (s, 1H), 5.35 (s, 2H), 3.52 (t,J = 6.5 Hz, 4H), 2.55 (s, 3H), 2.26 (s, 3H), 1.96 (s, 4H)。 13 C NMR (151 MHz, CDCl3 ) δ 167.15, 155.11, 149.43, 139.75, 137.73, 132.79, 131.31, 130.89 (q,J = 32.3 Hz), 129.02, 128.89, 124.75 (p,J = 3.9 Hz), 123.56 (q,J = 413.9 Hz), 122.18, 121.87, 65.07, 48.72, 45.36, 24.96, 21.86, 17.41。 19 F NMR (564 MHz, CDCl3 ) δ - 62.62。 | |
129 | (薄膜)2937, 2855, 1708, 1628, 1590, 1547, 1329, 1240, 1111, 701 | 對於C23 H26 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為419.1941;實測值為419.1951 | 1 H NMR(600 MHz, CDCl3 ) δ 7.80 (s, 1H), 7.70 (d,J = 1.7 Hz, 1H), 7.63 (d,J = 7.7 Hz, 1H), 7.58 (d,J = 7.8 Hz, 1H), 7.50 (t,J = 7.7 Hz, 1H), 7.43 (s, 1H), 6.59 (s, 1H), 5.35 (s, 2H), 4.10 - 3.09 (m, 4H), 2.55 (s, 3H), 2.24 (s, 3H), 1.73 - 1.66 (m, 2H), 1.66 - 1.59 (m, 4H)。 19 F NMR (564 MHz, CDCl3 ) δ - 62.63。 | |
130 | (薄膜)2958, 2928, 1705, 1633, 1593, 1247, 1108, 1086, 815 | 對於C24 H33 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為381.2537;實測值為381.2543 | 1 H NMR(400 MHz, CDCl3 ) δ 7.81 (s, 1H), 7.43 (d,J = 19.5 Hz, 1H), 7.36 - 7.27 (m, 2H), 7.14 (d,J = 7.9 Hz, 2H), 6.55 (s, 1H), 5.91 (dd,J = 7.7, 6.2 Hz, 1H), 3.40 (d,J = 72.3 Hz, 2H), 3.00 (s, 3H), 2.53 (s, 3H), 2.32 (s, 3H), 2.25 (s, 3H), 2.02 (dddd,J = 13.3, 10.0, 7.7, 5.4 Hz, 1H), 1.83 (ddt,J = 13.6, 9.9, 6.0 Hz, 1H), 1.54 - 1.25 (m, 2H), 1.21 (t,J = 7.2 Hz, 3H), 0.94 (t,J = 7.4 Hz, 3H)。 13 C NMR (101 MHz, CDCl3 ) δ 166.97, 154.51, 151.73, 139.41, 138.52, 137.19, 132.74, 129.04, 128.75, 126.53, 122.96, 121.96, 75.62, 47.72, 38.81, 37.24, 31.92, 21.90, 21.14, 18.97, 17.51, 13.90。 | |
131 | (薄膜)2923, 1705, 1632, 1593, 1548, 1246, 1108, 1086 | 對於C24 H31 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為379.2380;實測值為379.2386 | 1 H NMR(400 MHz, CDCl3 ) δ 7.81 (s, 1H), 7.44 (q,J = 13.0, 10.0 Hz, 1H), 7.34 - 7.28 (m, 2H), 7.15 (d,J = 7.9 Hz, 2H), 6.55 (s, 1H), 5.97 (dd,J = 7.6, 6.0 Hz, 1H), 5.79 (ddt,J = 17.1, 10.3, 6.9 Hz, 1H), 5.11 (dq,J = 17.1, 1.6 Hz, 1H), 5.05 (dq,J = 10.1, 1.2 Hz, 1H), 3.41 (d,J = 70.9 Hz, 2H), 3.00 (s, 3H), 2.78 (dtt,J = 14.6, 7.3, 1.3 Hz, 1H), 2.71 - 2.58 (m, 1H), 2.53 (s, 3H), 2.33 (s, 3H), 2.25 (s, 3H), 1.21 (t,J = 7.1 Hz, 3H)。 13 C NMR (101 MHz, CDCl3 ) δ 166.81, 154.59, 151.73, 139.47, 137.74, 137.37, 133.83, 132.80, 129.07, 128.76, 126.56, 122.80, 121.94, 117.79, 75.05, 47.80, 41.06, 37.45, 31.95, 21.90, 21.15, 17.51。 | |
132 | (薄膜)2956, 2924, 1704, 1632, 1593, 1548, 1367, 1246, 1107 | 對於C25 H35 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為395.2693;實測值為395.2702 | 1 H NMR(400 MHz, CDCl3 ) δ 7.80 (s, 1H), 7.42 (d,J = 20.5 Hz, 1H), 7.35 - 7.26 (m, 2H), 7.14 (d,J = 7.8 Hz, 2H), 6.54 (s, 1H), 5.98 (dd,J = 8.5, 5.3 Hz, 1H), 3.40 (d,J = 68.8 Hz, 2H), 3.00 (s, 3H), 2.52 (s, 3H), 2.32 (s, 3H), 2.25 (s, 3H), 2.06 1.90 (m, 1H), 1.68 (dtd,J = 12.8, 6.9, 2.6 Hz, 2H), 1.21 (t,J = 7.1 Hz, 3H), 0.96 (dd,J = 10.2, 6.2 Hz, 6H)。 13 C NMR (101 MHz, CDCl3 ) δ 166.93, 154.51, 151.71, 139.41, 138.79, 137.23, 132.74, 129.08, 128.74, 126.55, 122.98, 121.94, 74.29, 47.74, 45.83, 37.19, 31.88, 24.86, 22.86, 22.50, 21.88, 21.14, 17.50。 | |
133 | (薄膜)2964, 2925, 1704, 1631, 1592, 1547, 1366, 1244, 1107, 1085 | 對於C24 H33 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為381.2537;實測值為381.2543 | 1 H NMR(400 MHz, CDCl3 ) δ 7.84 (s, 1H), 7.39 (d,J = 47.1 Hz, 1H), 7.32 - 7.23 (m, 2H), 7.13 (d,J = 7.8 Hz, 2H), 6.55 (s, 1H), 5.66 (d,J = 7.2 Hz, 1H), 3.40 (d,J = 58.0 Hz, 2H), 3.01 (s, 3H), 2.54 (s, 3H), 2.32 (s, 3H), 2.26 (s, 3H), 2.25 - 2.17 (m, 1H), 1.21 (t,J = 7.2 Hz, 3H), 1.04 (d,J = 6.7 Hz, 3H), 0.88 (d,J = 6.8 Hz, 3H)。 13 C NMR (101 MHz, CDCl3 ) δ 166.88, 154.53, 151.74, 139.50, 137.31, 137.02, 132.75, 128.81, 128.76, 127.01, 122.98, 121.98, 80.70, 47.83, 37.33, 33.84, 31.97, 21.94, 21.14, 18.97, 18.68, 17.57。 | |
134 | (薄膜)2963, 2929, 1706, 1633, 1593, 1549, 1247, 1109, 1086 | 對於C26 H37 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為409.2850;實測值為409.2855 | 1 H NMR(400 MHz, CDCl3 ) δ 7.83 (s, 1H), 7.58 - 7.33 (m, 1H), 7.31 - 7.21 (m, 2H), 7.12 (d,J = 7.8 Hz, 2H), 6.55 (s, 1H), 5.92 (d,J = 7.0 Hz, 1H), 3.41 (d,J = 71.9 Hz, 2H), 3.01 (s, 3H), 2.53 (s, 3H), 2.32 (s, 3H), 2.26 (s, 3H), 1.89 - 1.65 (m, 1H), 1.65 - 1.39 (m, 2H), 1.39 - 1.24 (m, 2H), 1.21 (t,J = 7.2 Hz, 3H), 0.97 - 0.78 (m, 6H)。 13 C NMR (101 MHz, CDCl3 ) δ 166.83, 154.53, 151.76, 139.56, 137.69, 136.87, 132.77, 128.85, 128.76, 126.92, 123.01, 121.98, 77.12, 47.82, 46.36, 37.30, 32.02, 21.92, 21.78, 21.25, 21.13, 17.58, 11.18, 11.05。 | |
135 | (薄膜)2923, 1702, 1632, 1593, 1548, 1246, 1108, 967, 908, 731 | 對於C24 H31 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為379.2380;實測值為379.2386 | 1 H NMR(400 MHz, CDCl3 ) δ 7.82 (s, 1H), 7.44 (s, 1H), 7.39 - 7.32 (m, 2H), 7.15 (d,J = 7.9 Hz, 2H), 6.56 (s, 1H), 5.42 (d,J = 8.5 Hz, 1H), 3.63 - 3.18 (m, 2H), 3.01 (s, 3H), 2.54 (s, 3H), 2.33 (s, 3H), 2.25 (s, 3H), 1.51 - 1.34 (m, 1H), 1.21 (t,J = 7.2 Hz, 3H), 0.61 (dddd,J = 15.8, 9.3, 5.6, 3.4 Hz, 3H), 0.51 - 0.31 (m, 1H)。 13 C NMR (101 MHz, CDCl3 ) δ 167.06, 154.55, 151.75, 139.35, 138.08, 137.30, 132.78, 129.03, 128.78, 126.65, 123.08, 121.94, 79.23, 47.72, 37.296, 31.95, 21.84, 21.15, 17.49, 16.85, 4.11, 3.13。 | |
136 | (薄膜)2954, 1704, 1633, 1593, 1549, 1246, 1109, 1085 | 對於C26 H35 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為407.2693;實測值為407.2699 | 1 H NMR(500 MHz, CDCl3 ) δ 7.80 (s, 1H), 7.44 (t,J = 16.6 Hz, 1H), 7.35 - 7.28 (m, 2H), 7.12 (d,J = 7.8 Hz, 2H), 6.54 (s, 1H), 5.71 (d,J = 8.8 Hz, 1H), 3.40 (d,J = 92.9 Hz, 3H), 3.00 (s, 3H), 2.57 - 2.41 (m, 5H), 2.31 (s, 3H), 2.25 (s, 3H), 1.97 - 1.81 (m, 1H), 1.81 - 1.41 (m, 4H), 1.32 - 1.13 (m, 4H)。 13 C NMR (126 MHz, CDCl3 ) δ 166.99, 154.49, 139.39, 138.28, 137.10, 132.77, 128.91, 128.72, 126.99, 123.03, 121.94, 79.64, 47.78, 45.78, 32.04, 30.92, 29.78, 29.35, 25.33, 21.94, 21.16, 17.55。 | |
137 | (薄膜)2924, 1704, 1632, 1592, 1548, 1246, 1108, 1085, 731 | 對於C27 H37 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為421.2850;實測值為421.2859 | 1 H NMR(500 MHz, CDCl3 ) δ 7.83 (s, 1H), 7.42 (d,J = 29.0 Hz, 1H), 7.30 - 7.22 (m, 2H), 7.13 (d,J = 7.8 Hz, 2H), 6.55 (s, 1H), 5.68 (d,J = 7.6 Hz, 1H), 3.41 (d,J = 90.8 Hz, 2H), 3.01 (s, 3H), 2.53 (s, 3H), 2.32 (s, 3H), 2.26 (s, 3H), 2.17 (s, 2H), 2.01 - 1.92 (m, 1H), 1.87 (dtt,J = 11.1, 7.0, 3.6 Hz, 1H), 1.80 - 1.57 (m, 3H), 1.57 - 1.45 (m, 1H), 1.36 - 0.93 (m, 6H)。 13 C NMR (126 MHz, CDCl3 ) δ 166.90, 154.51, 139.50, 137.26, 137.02, 132.71, 128.80, 128.73, 127.12, 122.95, 121.97, 80.01, 47.80, 43.30, 37.33, 30.93, 29.25, 29.11, 26.38, 26.02, 25.98, 21.98, 21.16, 17.59。 | |
138 | (薄膜)2970, 1707, 1633, 1593, 1548, 1364, 1248, 1109, 1086 | 對於C25 H35 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為395.2693;實測值為395.2700 | 1 H NMR(500 MHz, CDCl3 ) δ 7.89 (s, 1H), 7.44 (d,J = 28.2 Hz, 1H), 7.30 - 7.21 (m, 2H), 7.10 (d,J = 7.9 Hz, 2H), 6.56 (s, 1H), 3.41 (d,J = 93.2 Hz, 2H), 3.01 (s, 3H), 2.54 (s, 3H), 2.31 (s, 3H), 2.28 (s, 3H), 2.17 (s, 1H), 1.22 (t,J = 7.1 Hz, 3H), 1.01 (s, 9H)。 13 C NMR (126 MHz, CDCl3 ) δ 166.61, 154.55, 139.70, 136.85, 136.01, 132.71, 128.77, 128.30, 127.77, 122.90, 122.01, 82.82, 47.82, 37.33, 35.32, 31.96, 30.93, 26.36, 22.03, 21.13, 17.68。 | |
139 | (薄膜)2962, 2932, 1707, 1633, 1593, 1548, 1328, 1246, 1109, 703 | 對於C24 H30 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為435.2254;實測值為435.2262 | 1 H NMR(500 MHz, CDCl3 ) δ 7.82 (s, 1H), 7.66 (d,J = 1.9 Hz, 1H), 7.64 - 7.57 (m, 1H), 7.53 (d,J = 7.9 Hz, 1H), 7.46 (q,J = 8.3, 7.7 Hz, 2H), 6.57 (s, 1H), 5.98 (dd,J = 8.0, 5.8 Hz, 1H), 3.42 (d,J = 98.1 Hz, 2H), 3.01 (s, 3H), 2.53 (s, 3H), 2.27 (s, 3H), 2.11 - 1.97 (m, 1H), 1.85 (ddt,J = 13.8, 10.0, 5.8 Hz, 1H), 1.55 - 1.29 (m, 2H), 1.22 (t,J = 7.1 Hz, 3H), 0.96 (t,J = 7.4 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 62.53。 | |
140 | (薄膜)2925, 1707, 1632, 1592, 1548, 1328, 1244, 1108, 701 | 對於C28 H30 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為483.2254;實測值為483.2263 | 1 H NMR(500 MHz, CDCl3 ) δ 7.77 (s, 1H), 7.56 (d,J = 1.8 Hz, 1H), 7.54 - 7.49 (m, 1H), 7.49 - 7.46 (m, 1H), 7.41 (t,J = 7.7 Hz, 1H), 7.28 - 7.15 (m, 3H), 7.14 - 7.08 (m, 2H), 6.55 (s, 1H), 6.17 (t,J = 6.8 Hz, 1H), 3.66 - 3.23 (m, 3H), 3.16 (dd,J = 13.7, 6.4 Hz, 1H), 3.02 (d,J = 5.1 Hz, 3H), 2.47 (s, 3H), 2.26 (s, 3H), 2.16 (s, 1H), 1.21 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 62.58。 | |
141 | (薄膜)2928, 1707, 1633, 1593, 1548, 1328, 1246, 1225, 1109, 733, 704 | 對於C27 H34 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為475.2567;實測值為475.2577 | 1 H NMR(500 MHz, CDCl3 ) δ 7.83 (s, 1H), 7.61 (d,J = 2.0 Hz, 1H), 7.59 - 7.49 (m, 2H), 7.48 (s, 1H), 6.57 (s, 1H), 5.75 (d,J = 7.3 Hz, 1H), 3.42 (d,J = 98.6 Hz, 2H), 3.01 (s, 3H), 2.53 (s, 3H), 2.28 (s, 3H), 1.90 (dddd,J = 22.3, 11.3, 7.0, 3.5 Hz, 2H), 1.83 - 1.60 (m, 4H), 1.49 (ddt,J = 13.6, 6.1, 2.6 Hz, 1H), 1.37 - 0.95 (m, 8H)。 19 F NMR (471 MHz, CDCl3 ) δ - 62.48。 | |
142 | (薄膜)2973, 2927, 1704, 1632, 1593, 1548, 1368, 1248, 1109, 1064, 759, 725 | 對於C22 H29 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為353.2224;實測值為353.2229 | 1 H NMR(500 MHz, CDCl3 ) δ 7.82 (s, 1H), 7.56 - 7.33 (m, 2H), 7.24 - 7.09 (m, 3H), 6.56 (s, 1H), 6.28 (p,J = 6.6, 6.1 Hz, 1H), 3.41 (d,J = 94.1 Hz, 2H), 3.00 (s, 3H), 2.54 (s, 3H), 2.44 (s, 3H), 2.26 (s, 3H), 1.61 (d,J = 6.5 Hz, 3H), 1.21 (t,J = 7.1 Hz, 3H)。 13 C NMR (126 MHz, CDCl3 ) δ 166.83, 154.56, 151.80, 140.74, 139.44, 134.66, 132.73, 130.37, 128.80, 127.38, 126.26, 125.36, 122.81, 121.98, 69.03, 47.78, 37.27, 31.93, 21.86, 21.65, 19.15, 17.51。 | |
143 | (薄膜)2974, 2925, 1705, 1633, 1593, 1549, 1247, 1110, 1065, 783 | 對於C22 H29 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為353.2224;實測值為353.2229 | 1 H NMR(500 MHz, CDCl3 ) δ 7.81 (s, 1H), 7.57 - 7.31 (m, 1H), 7.28 - 7.22 (m, 3H), 7.15 - 7.06 (m, 1H), 6.56 (s, 1H), 6.05 (q,J = 6.6 Hz, 1H), 3.41 (d,J = 93.4 Hz, 2H), 3.00 (s, 3H), 2.54 (s, 3H), 2.36 (s, 3H), 2.25 (s, 3H), 1.63 (d,J = 6.6 Hz, 3H), 1.21 (t,J = 7.1 Hz, 3H)。 | |
144 | ESIMSm/z 353 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.76 (s, 1H), 7.46 (s, 1H), 7.30 (d,J = 7.6 Hz, 1H), 7.07 - 7.00 (m, 2H), 6.56 (s, 1H), 5.27 (s, 2H), 3.41 (d,J = 90.0 Hz, 2H), 3.01 (s, 3H), 2.54 (s, 3H), 2.38 (s, 3H), 2.33 (s, 3H), 2.21 (s, 3H), 1.21 (t,J = 7.1 Hz, 3H)。 13 C NMR (126 MHz, CDCl3 ) δ 167.52, 154.61, 151.77, 139.59, 138.07, 137.01, 132.79, 131.57, 131.16, 129.52, 128.80, 126.57, 122.45, 121.98, 64.39, 47.84, 31.96, 21.84, 21.11, 18.97, 17.43, 14.30。 | ||
145 | 110-112 | ESIMSm/z 367 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.70 (s, 1H), 7.43 (d,J = 23.6 Hz, 1H), 6.91 (d,J = 5.3 Hz, 2H), 6.55 (s, 1H), 5.33 (s, 2H), 3.31 (s, 2H), 3.00 (s, 3H), 2.53 (s, 3H), 2.40 (s, 6H), 2.29 (s, 3H), 2.19 (s, 3H), 1.22 (d,J = 7.2 Hz, 3H)。 13 C NMR (126 MHz, CDCl3 ) δ 167.87, 154.57, 151.78, 139.49, 138.36, 138.17, 132.81, 129.67, 128.98, 128.77, 122.48, 121.97, 60.77, 47.84, 32.28, 21.83, 21.04, 19.66, 17.37, 14.32。 | |
146 | ESIMSm/z 395 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.72 (s, 1H), 7.45 (s, 1H), 6.55 (s, 1H), 5.40 (s, 2H), 3.31 (s, 2H), 3.00 (s, 3H), 2.55 (s, 3H), 2.35 (s, 6H), 2.27 (s, 3H), 2.26 (s, 6H), 2.18 (s, 3H), 1.21 (t,J = 7.3 Hz, 3H)。 13 C NMR (126 MHz, CDCl3 ) δ 167.94, 154.54, 151.78, 139.50, 135.69, 134.12, 132.88, 132.75, 129.85, 128.73, 122.55, 121.95, 61.98, 47.85, 32.03, 21.84, 17.32, 17.13, 16.73, 16.49, 14.39。 | ||
147 | ESIMSm/z 375 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.76 (s, 1H), 7.49 (s, 1H), 7.11 (ddd,J = 8.1, 6.4, 1.8 Hz, 1H), 6.96 - 6.91 (m, 1H), 6.56 (s, 1H), 5.33 (d,J = 1.3 Hz, 2H), 3.32 (s, 2H), 3.01 (s, 3H), 2.54 (s, 3H), 2.31 (d,J = 2.2 Hz, 3H), 2.23 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 142.57 (d,J = 19.8 Hz), - 143.59 (d,J = 19.9 Hz)。 | ||
148 | ESIMSm/z 373 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.78 (d,J = 2.1 Hz, 1H), 7.47 (d,J = 12.5 Hz, 1H), 7.33 (d,J = 8.1 Hz, 1H), 7.30 (d,J = 2.2 Hz, 1H), 7.24 - 7.19 (m, 1H), 6.57 (d,J = 4.1 Hz, 1H), 5.23 (s, 2H), 3.33 (s, 2H), 3.01 (s, 3H), 2.54 (s, 3H), 2.38 (d,J = 5.3 Hz, 3H), 2.24 (d,J = 6.0 Hz, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 13 C NMR (126 MHz, CDCl3 ) δ 167.75 - 167.02 (m), 154.79, 151.83, 139.71 (d,J = 9.5 Hz), 136.17, 135.23, 132.86 - 132.74 (m), 131.01, 130.78, 129.16, 128.90, 126.93, 126.42, 122.00, 65.26, 47.86, 31.98, 21.86, 20.07, 17.45, 14.34。 | ||
149 | ESIMSm/z 384 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 8.06 (d,J = 1.9 Hz, 1H), 7.79 (s, 1H), 7.58 (dd,J = 7.8, 1.8 Hz, 1H), 7.49 (s, 1H), 7.35 (d,J = 7.9 Hz, 1H), 6.58 (s, 1H), 5.32 (s, 2H), 3.42 (d,J = 93.7 Hz, 2H), 3.02 (s, 3H), 2.61 (s, 3H), 2.55 (s, 3H), 2.24 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 13 C NMR (126 MHz, CDCl3 ) δ 167.07, 155.01, 151.84, 149.22, 139.86, 136.24, 133.21, 133.02, 132.80, 132.52, 129.02, 124.17, 122.05, 121.71, 64.43, 47.90, 31.98, 21.89, 20.26, 17.48, 14.35。 | ||
150 | 78-79 | ESIMSm/z 411 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.81 (s, 1H), 7.61 (t,J = 7.7 Hz, 1H), 7.50 (s, 1H), 7.33 - 7.26 (m, 2H), 6.59 (s, 1H), 5.33 (s, 2H), 3.34 (s, 2H), 3.02 (s, 3H), 2.56 (s, 3H), 2.25 (s, 3H), 1.23 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 61.30 (d,J = 12.4 Hz), - 114.01 (td,J = 12.0, 7.4 Hz)。 | |
151 | 50-51 | ESIMSm/z 423 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.80 (s, 1H), 7.68 (d,J = 2.4 Hz, 1H), 7.57 (dd,J = 8.8, 2.3 Hz, 1H), 7.48 (s, 1H), 6.96 (d,J = 8.5 Hz, 1H), 6.58 (s, 1H), 5.36 (s, 2H), 3.91 (s, 3H), 3.42 (d,J = 90.3 Hz, 2H), 3.02 (s, 3H), 2.55 (s, 3H), 2.24 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 61.47。 | |
152 | ESIMSm/z 402 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 8.70 (dt,J = 4.8, 1.5 Hz, 1H), 8.02 - 7.99 (m, 2H), 7.82 (s, 1H), 7.78 - 7.72 (m, 2H), 7.58 - 7.53 (m, 2H), 7.48 (s, 1H), 7.23 (ddd,J = 6.7, 4.8, 2.1 Hz, 1H), 6.58 (s, 1H), 5.36 (s, 2H), 3.33 (s, 2H), 3.01 (s, 3H), 2.56 (s, 3H), 2.24 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 13 C NMR (126 MHz, CDCl3 ) δ 167.43, 157.10, 154.75, 151.82, 149.72, 139.64, 139.11, 137.47, 136.76, 132.85, 128.89, 128.52, 127.07, 122.17, 121.99, 120.55, 65.69, 47.84, 31.99, 30.94, 21.89, 17.45, 14.36。 | ||
153 | ESIMSm/z 427 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.84 (s, 1H), 7.67 (d,J = 1.8 Hz, 1H), 7.63 (d,J = 8.1 Hz, 1H), 7.54 (dd,J = 7.9, 1.8 Hz, 1H), 7.52 - 7.44 (m, 1H), 6.60 (s, 1H), 5.45 (s, 2H), 3.33 (s, 2H), 3.02 (s, 3H), 2.56 (s,J = 4.8 Hz, 3H), 2.25 (s,J = 4.4 Hz, 3H), 1.23 (t,J = 7.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 62.76。 | ||
154 | 60-62 | ESIMSm/z 461 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.90 (s, 2H), 7.84 (s, 1H), 7.80 (s, 1H), 7.49 (s, 1H), 6.59 (s, 1H), 5.40 (s, 2H), 3.34 (s, 2H), 3.02 (d,J = 2.2 Hz, 3H), 2.55 (s, 3H), 2.25 (s, 3H), 1.23 (td,J = 7.1, 3.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 62.87。 | |
155 | 73-74 | ESIMSm/z 407 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.79 (s, 1H), 7.50 (s, 2H), 7.43 (s, 1H), 7.39 (s, 1H), 6.58 (s, 1H), 5.31 (s, 2H), 3.33 (s, 2H), 3.02 (s, 3H), 2.55 (s, 3H), 2.43 (s, 3H), 2.24 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 62.56。 | |
156 | 75-76 | ESIMSm/z 407 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.78 (s, 1H), 7.62 (d,J = 7.8 Hz, 2H), 7.49 (d,J = 9.5 Hz, 1H), 7.30 (t,J = 7.8 Hz, 1H), 6.58 (s, 1H), 5.36 (s, 2H), 3.33 (s, 2H), 3.02 (s, 3H), 2.55 (s, 3H), 2.51 (d,J = 1.8 Hz, 3H), 2.24 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 60.46。 | |
157 | ESIMSm/z 357 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.79 (s, 1H), 7.48 (s, 1H), 7.17 (t,J = 7.9 Hz, 1H), 7.13 - 7.08 (m, 2H), 6.57 (s, 1H), 5.25 (s, 2H), 3.33 (s, 2H), 3.01 (s, 3H), 2.55 (s, 3H), 2.27 (d,J = 2.0 Hz, 3H), 2.23 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 117.34。 | ||
158 | ESIMSm/z 411 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.80 (s, 1H), 7.62 (t,J = 7.5 Hz, 1H), 7.49 (s, 1H), 7.46 - 7.41 (m, 1H), 7.40 - 7.32 (m, 1H), 6.58 (s, 1H), 5.41 (s, 2H), 3.33 (s, 2H), 3.02 (s, 3H), 2.55 (s, 3H), 2.24 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 62.77, - 115.46 (d,J = 8.0 Hz)。 | ||
159 | ESIMSm/z 369 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.78 (s, 1H), 7.46 (s, 1H), 7.29 (d,J = 7.5 Hz, 1H), 6.81 - 6.75 (m, 1H), 6.72 (d,J = 1.5 Hz, 1H), 6.55 (s, 1H), 5.31 (s, 2H), 3.84 (s, 3H), 3.32 (s, 2H), 3.00 (s, 3H), 2.54 (s, 3H), 2.36 (s, 3H), 2.22 (s, 3H), 1.21 (t,J = 7.1 Hz, 3H)。 13 C NMR (126 MHz, CDCl3 ) δ 167.75, 157.55, 154.45, 151.80, 139.44, 139.36, 132.83, 129.67, 128.69, 122.92, 121.99, 121.92, 120.95, 111.41, 61.47, 55.37, 47.89, 31.97, 21.74, 21.67, 17.42, 14.33。 | ||
160 | ESIMSm/z 407 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.78 (s, 1H), 7.71 - 7.66 (m, 1H), 7.54 - 7.49 (m, 1H), 7.48 (s, 1H), 7.29 (d,J = 7.9 Hz, 1H), 6.57 (s, 1H), 5.29 (s, 2H), 3.33 (s, 2H), 3.01 (s, 3H), 2.55 (s, 3H), 2.49 (p,J = 2.3, 1.9 Hz, 3H), 2.23 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 61.73。 | ||
161 | 62-64 | ESIMSm/z 411 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.78 (d,J = 5.7 Hz, 2H), 7.60 (ddd,J = 7.8, 4.5, 2.4 Hz, 1H), 7.47 (d,J = 15.0 Hz, 1H), 7.21 (t,J = 9.0 Hz, 1H), 6.58 (s, 1H), 5.39 (d,J = 1.1 Hz, 2H), 3.33 (s, 2H), 3.02 (d,J = 3.7 Hz, 3H), 2.55 (s, 3H), 2.24 (s, 3H), 1.23 (td,J = 7.2, 3.9 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 61.97, - 112.09 (d,J = 99.9 Hz)。 | |
162 | 63-64 | ESIMSm/z 407 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.81 (s, 1H), 7.61 (d,J = 8.4 Hz, 1H), 7.52 - 7.44 (m, 1H), 7.37 - 7.31 (m, 2H), 6.58 (s, 1H), 5.31 (s, 2H), 3.33 (s, 2H), 3.02 (s, 3H), 2.56 (s, 3H), 2.50 (q,J = 1.9 Hz, 3H), 2.24 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 61.55。 | |
163 | ESIMSm/z 407 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.80 (s, 1H), 7.69 (d,J = 1.8 Hz, 1H), 7.62 (dd,J = 7.7, 1.8 Hz, 1H), 7.57 - 7.53 (m, 1H), 7.48 (t,J = 7.7 Hz, 2H), 6.57 (s, 1H), 6.11 (q,J = 6.6 Hz, 1H), 3.33 (s, 2H), 3.02 (s, 3H), 2.53 (s, 3H), 2.26 (s, 3H), 1.66 (d,J = 6.6 Hz, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 62.57。 | ||
164 | ESIMSm/z 423 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.82 (s, 1H), 7.54 - 7.49 (m, 1H), 7.48 (s, 1H), 7.25 - 7.20 (m, 1H), 7.10 (d,J = 1.6 Hz, 1H), 6.58 (s, 1H), 5.38 (s, 2H), 3.91 (s, 3H), 3.33 (s, 2H), 3.02 (s, 3H), 2.55 (s, 3H), 2.25 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 62.51。 | ||
165 | ESIMSm/z 392 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.93 (s, 1H), 7.76 (s, 1H), 7.74 - 7.67 (m, 2H), 7.50 - 7.43 (m, 3H), 7.43 - 7.36 (m, 1H), 6.56 (s, 1H), 5.41 (s, 2H), 3.32 (s, 2H), 3.00 (s, 3H), 2.55 (s, 3H), 2.19 (s, 3H), 1.21 (t,J = 7.1 Hz, 3H)。 | ||
166 | ESIMSm/z 367 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.76 (s, 1H), 7.39 (s, 1H), 7.17 (s, 1H), 6.99 (s, 1H), 6.56 (s, 1H), 5.25 (s, 2H), 3.41 (d,J = 89.8 Hz, 2H), 3.01 (s, 3H), 2.55 (s, 3H), 2.35 (s, 3H), 2.24 (s, 6H), 2.21 (s, 3H), 1.21 (t,J = 7.2 Hz, 3H)。 13 C NMR (126 MHz, CDCl3 ) δ 167.56, 154.40, 151.81, 139.56, 136.67, 134.47, 133.91, 132.82, 131.78, 131.76, 131.10, 128.77, 122.59, 122.01, 64.50, 47.87, 32.01, 21.83, 19.38, 19.19, 18.45, 17.41, 14.30。 | ||
167 | ESIMSm/z 343 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.79 (s, 1H), 7.48 (td,J = 7.5, 1.9 Hz, 2H), 7.32 (tdd,J = 7.5, 5.3, 1.8 Hz, 1H), 7.15 (td,J = 7.5, 1.2 Hz, 1H), 7.09 (ddd,J = 9.6, 8.1, 1.1 Hz, 1H), 6.57 (s, 1H), 5.37 (d,J = 1.1 Hz, 2H), 3.42 (d,J = 90.0 Hz, 2H), 3.01 (s, 3H), 2.54 (s, 3H), 2.23 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 117.95。 | ||
168 | ESIMSm/z 343 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.80 (s, 1H), 7.46 (d,J = 20.3 Hz, 1H), 7.34 (td,J = 7.9, 5.8 Hz, 1H), 7.23 - 7.19 (m, 1H), 7.16 (dt,J = 9.6, 2.1 Hz, 1H), 7.05 - 6.99 (m, 1H), 6.58 (s, 1H), 5.30 (s, 2H), 3.33 (s, 2H), 3.02 (s, 3H), 2.55 (s, 3H), 2.24 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 113.00。 | ||
169 | ESIMSm/z 343 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.77 (s, 1H), 7.48 (s, 1H), 7.45 - 7.39 (m, 2H), 7.09 - 7.03 (m, 2H), 6.57 (s, 1H), 5.26 (s, 2H), 3.42 (d,J = 92.1 Hz, 2H), 3.01 (s, 3H), 2.54 (s, 3H), 2.23 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 114.22。 | ||
170 | ESIMSm/z 357 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.71 (s, 1H), 7.46 (s, 1H), 7.23 (td,J = 8.0, 5.8 Hz, 1H), 7.01 (d,J = 7.6 Hz, 1H), 6.95 (t,J = 8.9 Hz, 1H), 6.55 (s, 1H), 5.38 (d,J = 1.7 Hz, 2H), 3.32 (s, 2H), 3.00 (s, 3H), 2.53 (s, 3H), 2.45 (s, 3H), 2.20 (s, 3H), 1.21 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 117.45 (dd,J = 9.9, 5.8 Hz)。 | ||
171 | 87-88 | ESIMSm/z 357 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.75 (s, 1H), 7.45 (s, 1H), 7.38 (dd,J = 8.4, 5.9 Hz, 1H), 6.96 - 6.86 (m, 2H), 6.57 (s, 1H), 5.26 (s, 2H), 3.32 (s, 2H), 3.01 (s, 3H), 2.54 (s, 3H), 2.41 (s, 3H), 2.22 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 114.63。 | |
172 | ESIMSm/z 357 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.77 (s, 1H), 7.29 - 7.20 (m, 3H), 6.99 (dd,J = 9.6, 8.2 Hz, 1H), 6.57 (s, 1H), 5.23 (s, 2H), 3.32 (s, 2H), 3.01 (s, 3H), 2.54 (s, 3H), 2.28 (d,J = 2.0 Hz, 3H), 2.23 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 118.58。 | ||
173 | ESIMSm/z 373 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.75 (s, 1H), 7.38 (t,J = 8.5 Hz, 1H), 6.72 - 6.63 (m, 2H), 6.55 (s, 1H), 5.29 (d,J = 1.1 Hz, 2H), 3.81 (s, 3H), 3.41 (d,J = 89.6 Hz, 2H), 3.01 (s, 3H), 2.53 (s, 3H), 2.22 (s, 3H), 1.21 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 115.40 --115.85 (m)。 | ||
174 | ESIMSm/z 377 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.80 (s, 1H), 7.49 (dd,J = 8.6, 6.0 Hz, 1H), 7.40 (s, 1H), 7.17 (dd,J = 8.4, 2.6 Hz, 1H), 7.00 (td,J = 8.3, 2.6 Hz, 1H), 6.58 (s, 1H), 5.37 (s, 2H), 3.33 (s, 2H), 3.02 (s, 3H), 2.55 (s, 3H), 2.24 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 111.90 - -112.17 (m)。 | ||
175 | ESIMSm/z 365 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.78 (s, 1H), 7.37 - 7.32 (m, 2H), 7.18 (d,J = 7.8 Hz, 2H), 6.49 (s, 1H), 5.26 (s, 2H), 3.26 (t,J = 6.1 Hz, 2H), 3.01 (s, 3H), 2.52 (s, 3H), 2.36 (s, 3H), 2.08 (t,J = 6.5 Hz, 2H), 2.04 (s, 3H), 1.83 - 1.76 (m, 2H), 1.66 - 1.60 (m, 2H)。 13 C NMR (126 MHz, CDCl3 ) δ 167.57, 156.16, 154.50, 139.29, 137.74, 133.69, 132.96, 129.18, 128.34, 126.86, 124.95, 121.90, 65.91, 50.66, 37.25, 27.01, 23.72, 21.83, 21.41, 21.22, 17.46。 | ||
176 | 106-108 | ESIMSm/z 399 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.68 (s, 1H), 7.43 (s, 1H), 6.53 (s, 1H), 6.40 (s, 2H), 5.35 (s, 2H), 3.81 (s, 6H), 3.39 (d,J = 81.7 Hz, 2H), 2.99 (s, 3H), 2.50 (s, 3H), 2.37 (s, 3H), 2.18 (s, 3H), 1.20 (t,J = 7.1 Hz, 3H)。 13 C NMR (126 MHz, CDCl3 ) δ 168.44, 159.40, 154.08, 151.75, 140.48, 138.93, 132.83, 128.48, 123.61, 121.80, 109.67, 104.62, 55.79, 52.39, 47.79, 31.96, 22.32, 21.54, 17.34, 14.30。 | |
177 | 75-77 | ESIMSm/z 273 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.80 (s, 1H), 7.49 (s, 1H), 6.58 (s, 1H), 4.86 (d,J = 2.4 Hz, 2H), 3.33 (s, 2H), 3.02 (s, 3H), 2.56 (s, 3H), 2.48 (t,J = 2.4 Hz, 1H), 2.25 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 13 C NMR (126 MHz, CDCl3 ) δ 166.60, 155.00, 151.83, 139.99, 132.95, 128.94, 121.98, 121.47, 78.43, 74.42, 51.61, 47.88, 31.99, 21.80, 17.43, 14.33。 | |
178 | ESIMSm/z 287 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.80 (s, 1H), 7.48 (s, 1H), 6.57 (s, 1H), 4.83 (q,J = 2.4 Hz, 2H), 3.42 (d,J = 93.8 Hz, 2H), 3.02 (s, 3H), 2.56 (s, 3H), 2.24 (s, 3H), 1.88 (t,J = 2.4 Hz, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 13 C NMR (126 MHz, CDCl3 ) δ 166.88, 154.81, 151.82, 139.83, 132.91, 128.85, 121.96, 121.87, 82.64, 73.86, 52.42, 47.85, 31.98, 21.77, 17.41, 14.33, 3.75。 | ||
179 | (薄膜)2971, 2931, 1708, 1631, 1576, 1251, 1142, 1065, 778 | ESIMSm/z 325 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.69 (d,J = 8.3 Hz, 1H), 7.47 - 7.35 (m, 5H), 7.35 - 7.29 (m, 1H), 6.61 (d,J = 8.4 Hz, 1H), 5.31 (s, 2H), 3.61 - 3.22 (m, 2H), 3.02 (s, 3H), 2.52 (s, 3H), 2.27 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H) | |
180 | 58-60 | ESIMSm/z 339 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.67 (d,J = 8.3 Hz, 1H), 7.45 - 7.40 (m, 2H), 7.26 - 7.17 (m, 3H), 6.60 (d,J = 8.3 Hz, 1H), 5.32 (s, 2H), 3.64 - 3.23 (m, 2H), 3.02 (s, 3H), 2.53 (s, 3H), 2.41 (s, 3H), 2.27 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H) | |
181 | (薄膜)2973, 2933, 1711, 1631, 1576, 1314, 1250, 1117, 1060, 769 | ESIMSm/z 393 [(M+H)+ ] | 1 H NMR(400 MHz, CDCl3 ) δ 7.76 - 7.63 (m, 3H), 7.56 (t,J = 7.5 Hz, 1H), 7.47 - 7.36 (m, 2H), 6.62 (d,J = 8.3 Hz, 1H), 5.51 (s, 2H), 3.64 - 3.22 (m, 2H), 3.02 (s, 3H), 2.53 (s, 3H), 2.28 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H) 19 F NMR (376 MHz, CDCl3 ) δ - 59.96 | |
182 | (薄膜)2972, 2931, 1709, 1630, 1574, 1366, 1250, 1142, 1066, 753 | ESIMSm/z 360 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.72 (d,J = 8.3 Hz, 1H), 7.53 - 7.49 (m, 1H), 7.46 - 7.38 (m, 2H), 7.29 - 7.26 (m, 2H), 6.62 (d,J = 8.3 Hz, 1H), 5.42 (s, 2H), 3.62 - 3.25 (m, 2H), 3.02 (s, 3H), 2.53 (s, 3H), 2.28 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H) | |
183 | (薄膜)2973, 2934, 1710, 1631, 1576, 1330, 1250, 1123, 1066, 778 | ESIMSm/z 393 [(M+H)+ ] | 1 H NMR(400 MHz, CDCl3 ) δ 7.69 (d,J = 8.5 Hz, 2H), 7.63 (d,J = 7.7 Hz, 1H), 7.59 (d,J = 7.8 Hz, 1H), 7.50 (t,J = 7.8 Hz, 1H), 7.43 (s, 1H), 6.63 (d,J = 8.4 Hz, 1H), 5.35 (s, 2H), 3.63 - 3.18 (m, 2H), 3.02 (s, 3H), 2.52 (s, 3H), 2.28 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 62.64。 | |
184 | (薄膜)2933, 1706, 1630, 1575, 1514, 1366, 1245, 1141, 1064, 822 | ESIMSm/z 355 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.64 (d,J = 8.3 Hz, 1H), 7.46 - 7.36 (m, 3H), 6.90 (d,J = 8.7 Hz, 2H), 6.59 (d,J = 8.3 Hz, 1H), 5.24 (s, 2H), 3.81 (s, 3H), 3.60 - 3.24 (m, 2H), 3.01 (s, 3H), 2.50 (s, 3H), 2.26 (s, 3H), 1.21 (t,J = 7.1 Hz, 3H) | |
185 | (薄膜)2965, 2930, 1707, 1630, 1575, 1365, 1250, 1141, 1064, 969, 821 | ESIMSm/z 354 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.67 (d,J = 8.3 Hz, 1H), 7.42 (s, 1H), 7.36 (d,J = 8.0 Hz, 2H), 7.21 (d,J = 8.0 Hz, 2H), 6.60 (d,J = 8.4 Hz, 1H), 5.28 (s, 2H), 3.59 - 3.25 (m, 2H), 3.01 (s, 3H), 2.66 (q,J = 7.6 Hz, 2H), 2.52 (s, 3H), 2.27 (s, 3H), 1.24 (t,J = 7.6 Hz, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 | |
186 | 67-70 | ESIMSm/z 393 [(M+H)+ ] | 1 H NMR(400 MHz, CDCl3 ) δ 7.70 (d,J = 8.4 Hz, 1H), 7.63 (d,J = 8.1 Hz, 2H), 7.55 (d,J = 8.1 Hz, 2H), 7.47 - 7.37 (m, 1H), 6.62 (d,J = 8.4 Hz, 1H), 5.36 (s, 2H), 3.62 - 3.22 (m, 2H), 3.02 (s, 3H), 2.52 (s, 3H), 2.28 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 62.57。 | |
187 | 92-95 | ESIMSm/z 360 [(M+H)+ ] | 1 H NMR(400 MHz, CDCl3 ) δ 7.66 (d,J = 8.4 Hz, 1H), 7.47 - 7.31 (m, 5H), 6.61 (d,J = 8.3 Hz, 1H), 5.27 (s, 2H), 3.60 - 3.27 (m, 2H), 3.02 (s, 3H), 2.51 (s, 3H), 2.27 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 | |
188 | 40-42 | ESIMSm/z 409 [(M+H)+ ] | 1 H NMR(400 MHz, CDCl3 ) δ 7.68 (d,J = 8.3 Hz, 1H), 7.47 (d,J = 8.7 Hz, 2H), 7.44 - 7.37 (m, 1H), 7.22 (d,J = 7.9 Hz, 2H), 6.61 (d,J = 8.4 Hz, 1H), 5.30 (s, 2H), 3.62 - 3.26 (m, 2H), 3.02 (s, 3H), 2.52 (s, 3H), 2.28 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 57.85。 | |
189 | 82-84 | ESIMSm/z 407 [(M+H)+ ] | 1 H NMR(400 MHz, CDCl3 ) δ 7.67 (d,J = 8.4 Hz, 1H), 7.62 (d,J = 7.8 Hz, 2H), 7.42 (s, 1H), 7.30 (t,J = 7.8 Hz, 1H), 6.62 (d,J = 8.3 Hz, 1H), 5.36 (s, 2H), 3.60 - 3.23 (m, 2H), 3.02 (s, 3H), 2.52 (s, 3H), 2.51 (s, 3H), 2.28 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 60.48。 | |
190 | 82-84 | ESIMSm/z 357 [(M+H)+ ] | 1 H NMR(400 MHz, CDCl3 ) δ 7.65 (d,J = 8.3 Hz, 1H), 7.41 (s, 1H), 7.35 (t,J = 7.7 Hz, 1H), 6.97 - 6.87 (m, 2H), 6.59 (d,J = 8.4 Hz, 1H), 5.32 (s, 2H), 3.58 - 3.25 (m, 2H), 3.01 (s, 3H), 2.50 (s, 3H), 2.35 (s, 3H), 2.26 (s, 3H), 1.21 (t,J = 7.1 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 118.94。 | |
191 | 102-105 | ESIMSm/z 374 [(M+H)+ ] | 1 H NMR(400 MHz, CDCl3 ) δ 7.65 (d,J = 8.3 Hz, 1H), 7.42 (s, 1H), 7.35 (d,J = 8.1 Hz, 1H), 7.22 - 7.14 (m, 2H), 6.60 (d,J = 8.4 Hz, 1H), 5.26 (s, 2H), 3.60 - 3.24 (m, 2H), 3.02 (s, 3H), 2.51 (s, 3H), 2.38 (s, 3H), 2.27 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 | |
192 | (薄膜)2972, 2930, 1709, 1630, 1575, 1365, 1250, 1140, 1064, 970, 778 | ESIMSm/z 357 [(M+H)+ ] | 1 H NMR(400 MHz, CDCl3 ) δ 7.68 (d,J = 8.3 Hz, 1H), 7.42 (s, 1H), 7.17 (t,J = 7.6 Hz, 1H), 7.10 (d,J = 9.0 Hz, 2H), 6.61 (d,J = 8.3 Hz, 1H), 5.25 (s, 2H), 3.62 - 3.24 (m, 2H), 3.02 (s, 3H), 2.52 (s, 3H), 2.27 (s, 6H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 117.33。 | |
193 | 65-67 | ESIMSm/z 411 [(M+H)+ ] | 1 H NMR(400 MHz, CDCl3 ) δ 7.69 (d,J = 8.3 Hz, 1H), 7.62 (t,J = 7.5 Hz, 1H), 7.48 - 7.33 (m, 3H), 6.62 (d,J = 8.3 Hz, 1H), 5.41 (s, 2H), 3.58 - 3.24 (m, 2H), 3.02 (s, 3H), 2.52 (s, 3H), 2.28 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 62.78, -115.44。 | |
194 | 63-65 | ESIMSm/z 375 [(M+H)+ ] | 1 H NMR(400 MHz, CDCl3 ) δ 7.66 (d,J = 8.3 Hz, 1H), 7.41 (s, 1H), 7.11 (t,J = 7.7 Hz, 1H), 6.93 (t,J = 7.3 Hz, 1H), 6.60 (d,J = 8.4 Hz, 1H), 5.33 (s, 2H), 3.57 - 3.22 (m, 2H), 3.02 (s, 3H), 2.51 (s, 3H), 2.31 (d,J = 2.2 Hz, 3H), 2.27 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 142.56 (d,J = 20.0 Hz), - 143.57 (d,J = 19.9 Hz)。 | |
195 | (薄膜)2970, 2922, 1707, 1630, 1575, 1364, 1250, 1142, 1064, 969, 778 | ESIMSm/z 353 [(M+H)+ ] | 1 H NMR(400 MHz, CDCl3 ) δ 7.67 (d,J = 8.3 Hz, 1H), 7.41 (s, 1H), 7.24 - 7.09 (m, 3H), 6.59 (d,J = 8.3 Hz, 1H), 5.24 (s, 2H), 3.58 - 3.24 (m, 2H), 3.01 (s, 3H), 2.52 (s, 3H), 2.31 - 2.24 (m, 9H), 1.21 (t,J = 7.1 Hz, 3H)。 | |
196 | (薄膜)2950, 1707, 1631, 1577, 1364, 1248, 1146, 1066, 970, 837 | ESIMSm/z 350 [(M+H)+ ] | 1 H NMR(400 MHz, CDCl3 ) δ 7.63 (d,J = 8.3 Hz, 1H), 7.42 (s, 1H), 6.62 (d,J = 8.3 Hz, 1H), 4.22 (t,J = 6.9 Hz, 2H), 3.58 - 3.26 (m, 2H), 3.02 (s, 3H), 2.50 (s, 3H), 2.27 (s, 3H), 1.73 (ddt,J = 11.3, 8.5, 7.0 Hz, 2H), 1.22 (t,J = 7.1 Hz, 3H), 0.63 - 0.53 (m, 2H), 0.01 (s, 9H)。 | |
197 | (薄膜)2972, 2935, 1709, 1631, 1576, 1377, 1250, 1145, 1065, 1030, 779 | ESIMSm/z 345 [(M+H)+ ] | 1 H NMR(400 MHz, CDCl3 ) δ 7.62 (d,J = 8.3 Hz, 1H), 7.43 (s, 1H), 6.63 (d,J = 8.3 Hz, 1H), 4.32 (t,J = 6.3 Hz, 2H), 3.59 - 3.25 (m, 2H), 3.02 (s, 3H), 2.51 (s, 3H), 2.37 - 2.16 (m, 5H), 2.11 - 1.89 (m, 2H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 66.40。 | |
198 | (薄膜)2960, 2933, 1707, 1630, 1576, 1366, 1251, 1145, 1064, 1036, 970, 779 | ESIMSm/z 291 [(M+H)+ ] | 1 H NMR(400 MHz, CDCl3 ) δ 7.64 (d,J = 8.3 Hz, 1H), 7.42 (s, 1H), 6.62 (d,J = 8.3 Hz, 1H), 4.05 (d,J = 6.6 Hz, 2H), 3.61 - 3.26 (m, 2H), 3.02 (s, 3H), 2.51 (s, 3H), 2.27 (s, 3H), 2.06 (hept,J = 6.8 Hz, 1H), 1.22 (t,J = 7.1 Hz, 3H), 1.01 (d,J = 6.7 Hz, 6H)。 | |
199 | (薄膜)3226, 2968, 1717, 1520, 1330, 1249, 1124, 1074, 800 | ESIMSm/z 425 [(M+H)+ ] | 1 H NMR(400 MHz, CDCl3 ) δ 7.74 - 7.66 (m, 2H), 7.61 (t,J = 8.8 Hz, 2H), 7.51 (t,J = 7.7 Hz, 1H), 7.10 (d,J = 8.4 Hz, 1H), 6.77 (s, 1H), 5.37 (s, 2H), 3.87 (q,J = 7.2 Hz, 2H), 3.23 (s, 3H), 2.52 (s, 3H), 2.22 (s, 3H), 1.30 (t,J = 7.2 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 62.64。 | |
200 | 138-141 | ESIMSm/z 371 [(M+H)+ ] | 1 H NMR(400 MHz, CDCl3 ) δ 7.69 (d,J = 8.3 Hz, 1H), 7.43 - 7.38 (m, 1H), 7.25 - 7.16 (m, 3H), 7.07 (d,J = 8.4 Hz, 1H), 6.76 (s, 1H), 5.34 (s, 2H), 3.87 (q,J = 7.1 Hz, 2H), 3.22 (s, 3H), 2.52 (s, 3H), 2.41 (s, 3H), 2.21 (s, 3H), 1.30 (t,J = 7.2 Hz, 3H)。 | |
201 | 84-87 | ESIMSm/z 389 [(M+H)+ ] | 1 H NMR(400 MHz, CDCl3 ) δ 7.66 (d,J = 8.4 Hz, 1H), 7.33 (t,J = 7.7 Hz, 1H), 7.05 (d,J = 8.4 Hz, 1H), 6.95 (d,J = 7.2 Hz, 1H), 6.91 (d,J = 11.1 Hz, 1H), 6.78 (s, 1H), 5.34 (s, 2H), 3.86 (q,J = 7.1 Hz, 2H), 3.21 (s, 3H), 2.49 (s, 3H), 2.36 (s, 3H), 2.20 (s, 3H), 1.29 (t,J = 7.2 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 118.85。 | |
202 | (薄膜)3329, 3240, 2951, 1715, 1518, 1248, 1142, 1083, 837 | ESIMSm/z 381 [(M+H)+ ] | 1 H NMR(400 MHz, CDCl3 ) δ 7.65 (d,J = 8.3 Hz, 1H), 7.09 (d,J = 8.4 Hz, 1H), 6.78 (s, 1H), 4.24 (t,J = 6.9 Hz, 2H), 3.88 (q,J = 7.1 Hz, 2H), 3.22 (s, 3H), 2.50 (s, 3H), 2.21 (s, 3H), 1.79 - 1.66 (m, 2H), 1.30 (t,J = 7.2 Hz, 3H), 0.63 - 0.52 (m, 2H), 0.02 (s, 9H)。 | |
203 | 91-93 | ESIMSm/z 377 [(M+H)+ ] | 1 H NMR(400 MHz, CDCl3 ) δ 7.65 (d,J = 8.4 Hz, 1H), 7.11 (d,J = 8.4 Hz, 1H), 6.77 (s, 1H), 4.34 (t,J = 6.3 Hz, 2H), 3.88 (q,J = 7.2 Hz, 2H), 3.24 (s, 3H), 2.51 (s, 3H), 2.36 - 2.24 (m, 2H), 2.22 (s, 3H), 2.10 - 1.97 (m, 2H), 1.31 (t,J = 7.2 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 66.36。 | |
204 | ESIMSm/z 405 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.93 (d,J = 2.4 Hz, 1H), 7.78 (s, 1H), 7.72 (d,J = 1.7 Hz, 1H), 7.61 (d,J = 1.8 Hz, 1H), 7.49 (d,J = 1.9 Hz, 3H), 6.57 (s, 1H), 6.46 (t,J = 2.1 Hz, 1H), 5.33 (s, 2H), 3.41 (d,J = 93.3 Hz, 2H), 3.01 (s, 3H), 2.55 (s, 3H), 2.48 (s, 3H), 2.23 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 13 C NMR (126 MHz, CDCl3 ) δ 167.37, 154.78, 151.79, 141.06, 139.94, 139.67, 138.67, 132.92, 132.78, 130.39, 128.91, 126.75, 122.18, 122.00, 121.07, 116.38, 107.57, 63.83, 47.86, 31.98, 21.86, 19.24, 17.47, 14.32。 | ||
205 | ESIMSm/z 355 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.79 (s, 1H), 7.48 (s, 1H), 6.57 (s, 1H), 4.86 (d,J = 2.0 Hz, 2H), 3.42 (d,J = 91.1 Hz, 2H), 3.02 (s, 3H), 2.55 (s, 3H), 2.42 (q,J = 7.6, 6.2 Hz, 1H), 2.25 (s, 3H), 1.81 (dq,J = 12.8, 3.5 Hz, 2H), 1.71 (dh,J = 9.5, 3.5 Hz, 2H), 1.48 (dddd,J = 32.0, 16.2, 7.7, 3.5 Hz, 3H), 1.37 - 1.25 (m, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 13 C NMR (126 MHz, CDCl3 ) δ 166.95, 154.75, 151.82, 139.67, 132.90, 128.83, 122.09, 121.94, 91.18, 74.52, 52.56, 47.86, 32.47, 31.97, 29.14, 25.85, 24.87, 21.74, 17.42, 14.33。 | ||
206 | 102-104 | ESIMSm/z 384 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 8.33 (d,J = 2.5 Hz, 1H), 8.10 (dd,J = 8.4, 2.5 Hz, 1H), 7.80 (s, 1H), 7.50 (s, 1H), 7.36 (d,J = 8.3 Hz, 1H), 6.59 (s, 1H), 5.36 (s, 2H), 3.33 (s, 2H), 3.02 (s, 3H), 2.56 (s, 3H), 2.50 (s, 3H), 2.25 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 13 C NMR (126 MHz, CDCl3 ) δ 167.01, 155.09, 151.85, 146.50, 144.38, 139.92, 136.50, 132.80, 131.12, 129.09, 123.55, 123.01, 122.08, 121.58, 63.11, 47.83, 32.08, 21.89, 19.34, 17.52, 14.35。 | |
207 | ESIMSm/z 345 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.81 (s, 1H), 7.49 (s, 1H), 6.58 (s, 1H), 4.87 (d,J = 2.6 Hz, 2H), 3.43 (d,J = 95.7 Hz, 2H), 3.02 (s, 3H), 2.56 (d,J = 3.5 Hz, 3H), 2.25 (d,J = 2.4 Hz, 3H), 1.23 (t,J = 7.2 Hz, 3H), 0.20 (s, 9H)。 | ||
208 | (薄膜)2920, 1717, 1630, 1579, 1542, 1369, 1246, 1106, 1086, 998, 731 | ESIMSm/z 360 [(M+H)+ ] | 1 H NMR(600 MHz, CDCl3 ) δ 7.73 - 7.70 (m, 1H), 7.47 (s, 1H), 7.37 - 7.32 (m, 2H), 7.16 (d,J = 7.8 Hz, 2H), 6.78 (d,J = 8.0 Hz, 1H), 5.28 (s, 2H), 3.52 - 3.45 (m, 1H), 3.26 (q,J = 7.3 Hz, 1H), 2.99 - 2.94 (m, 3H), 2.33 (s, 3H), 2.21 (s, 3H), 1.17 (t,J = 7.2 Hz, 3H)。 13 C NMR (151 MHz, CDCl3 ) δ 165.45, 155.18, 152.10, 137.85, 133.31, 133.13, 132.27, 130.33, 129.17, 128.41, 121.63, 120.56, 66.54, 47.92, 41.70, 31.96, 21.17, 17.39, 14.25, 11.14。 | |
209 | (薄膜)2928, 1709, 1629, 1576, 1539, 1370, 1227, 1082, 905, 779, 731 | ESIMSm/z 359 [(M)+ ] | 1 H NMR(600 MHz, CDCl3 ) δ 8.00 (s, 1H), 7.54 (s, 1H), 7.34 - 7.30 (m, 2H), 7.18 (d,J = 7.9 Hz, 2H), 6.68 (d,J = 15.1 Hz, 1H), 5.25 (s, 2H), 3.54 (q,J = 7.3 Hz, 1H), 3.30 (q,J = 7.2 Hz, 1H), 3.04 (s, 2H), 2.99 (s, 1H), 2.57 - 2.52 (m, 3H), 2.35 (s, 3H), 1.21 (t,J = 7.2 Hz, 3H)。 13 C NMR (151 MHz, CDCl3 ) δ 166.19, 153.10, 152.43, 140.55, 137.94, 133.21, 132.34, 129.23, 128.38, 124.91, 123.85, 123.32, 66.27, 48.07, 37.69, 32.10, 21.69, 21.19, 14.28, 11.20。 | |
210 | (薄膜)2921, 1718, 1628, 1576, 1369, 1243, 1105, 1085, 973, 806 | ESIMSm/z 403 [(M+H)+ ] | 1 H NMR(600 MHz, CDCl3 ) δ 7.70 (d,J = 5.0 Hz, 1H), 7.40 - 7.31 (m, 2H), 7.19 (dd,J = 7.9, 3.1 Hz, 2H), 7.00 (s, 1H), 5.30 (d,J = 9.3 Hz, 2H), 3.89 (s, 1H), 3.61 - 3.44 (m, 1H), 3.32 (q,J = 6.6 Hz, 1H), 3.01 (s, 3H), 2.36 (d,J = 1.9 Hz, 3H), 2.18 (d,J = 17.0 Hz, 3H), 1.22 (dd,J = 11.4, 5.0 Hz, 3H)。 | |
211 | (薄膜)2969, 2929, 1715, 1629, 1595, 1369, 1249, 1227, 1190, 1111, 1071, 968, 806 | ESIMSm/z 339 [(M+H)+ ] | 1 H NMR(600 MHz, CDCl3 ) δ 7.54 (s, 1H), 7.45 (d,J = 2.4 Hz, 1H), 7.38 - 7.31 (m, 2H), 7.21 - 7.16 (m, 2H), 7.13 (d,J = 8.2 Hz, 1H), 7.03 (dd,J = 8.2, 2.5 Hz, 1H), 5.32 - 5.24 (m, 2H), 3.61 - 3.15 (m, 2H), 2.98 (s, 3H), 2.90 (q,J = 7.5 Hz, 2H), 2.36 (s, 3H), 1.18 (dt,J = 10.0, 7.3 Hz, 6H)。 13 C NMR (151 MHz, CDCl3 ) δ 167.88, 153.12, 149.92, 139.77, 137.92, 133.20, 130.81, 129.76, 129.19, 128.45, 125.20, 122.76, 66.45, 48.00, 32.16, 26.97, 21.21, 16.10, 14.31。 | |
212 | (薄膜)2965, 2929, 1705, 1631, 1586, 1563, 1368, 1256, 1231, 1107, 1085, 774 | ESIMSm/z 339 [(M+H)+ ] | 1 H NMR(600 MHz, CDCl3 ) δ 7.87 (d,J = 2.1 Hz, 1H), 7.82 (dd,J = 8.2, 2.1 Hz, 1H), 7.52 - 7.36 (m, 1H), 7.35 - 7.30 (m, 2H), 7.16 (d,J = 7.9 Hz, 2H), 6.73 (d,J = 8.2 Hz, 1H), 5.28 (s, 2H), 3.49 (s, 1H), 3.25 (s, 1H), 2.96 (d,J = 15.4 Hz, 3H), 2.72 (q,J = 7.5 Hz, 2H), 2.33 (s, 3H), 1.18 (q,J = 7.2 Hz, 6H)。 13 C NMR (151 MHz, CDCl3 ) δ 166.96, 155.11, 151.80, 137.74, 137.51, 133.57, 129.98, 129.17, 128.62, 128.23, 123.65, 118.36, 66.08, 47.74, 31.91, 24.80, 21.17, 14.45, 11.29。 | |
213 | (薄膜)2923, 1720, 1631, 1580, 1329, 1246, 1107, 1000, 907, 701 | ESIMSm/z 413 [(M)+ ] | 1 H NMR(600 MHz, CDCl3 ) δ 7.74 (d,J = 6.4 Hz, 2H), 7.64 (d,J = 7.7 Hz, 1H), 7.57 (d,J = 7.8 Hz, 1H), 7.49 (q,J = 7.7 Hz, 2H), 6.81 (d,J = 6.4 Hz, 1H), 5.37 (s, 2H), 3.52 (d,J = 7.8 Hz, 1H), 3.31 (q,J = 7.2 Hz, 1H), 3.01 (s, 3H), 2.24 (s, 3H), 1.20 (q,J = 7.6 Hz, 3H)。 19 F NMR (564 MHz, CDCl3 ) δ - 62.59。 | |
214 | (薄膜)2932, 1713, 1630, 1576, 1329, 1226, 1118, 1082, 906, 778, 701 | ESIMSm/z 414 [(M+H)+ ] | 1 H NMR(600 MHz, CDCl3 ) δ 8.01 (s, 1H), 7.69 (d,J = 1.8 Hz, 1H), 7.65 - 7.61 (m, 1H), 7.61 - 7.55 (m, 2H), 7.50 (t,J = 7.7 Hz, 1H), 6.71 (d,J = 15.0 Hz, 1H), 5.34 (s, 2H), 3.56 (q,J = 7.1 Hz, 1H), 3.33 (q,J = 7.2 Hz, 1H), 3.06 (s, 2H), 3.01 (s, 1H), 2.55 (s, 3H), 1.23 (t,J = 7.1 Hz, 3H)。 19 F NMR (564 MHz, CDCl3 ) δ - 62.60。 | |
215 | (薄膜)2934, 1718, 1630, 1576, 1329, 1244, 1108, 701 | ESIMSm/z 457 [(M+H)+ ] | 1 H NMR(600 MHz, CDCl3 ) δ 7.75 - 7.70 (m, 2H), 7.66 (d,J = 7.8 Hz, 1H), 7.59 (d,J = 7.6 Hz, 1H), 7.50 (td,J = 7.7, 4.6 Hz, 2H), 7.02 (d,J = 6.0 Hz, 1H), 5.39 (d,J = 9.5 Hz, 2H), 3.54 (dd,J = 18.3, 10.9 Hz, 1H), 3.33 (dt,J = 12.2, 6.0 Hz, 1H), 3.02 (s, 3H), 2.21 (d,J = 18.2 Hz, 3H), 1.22 (dq,J = 17.1, 7.3 Hz, 3H)。 19 F NMR (564 MHz, CDCl3 ) δ - 62.61。 | |
216 | (薄膜)2971, 2932, 1718, 1630, 1595, 1329, 1119, 1072, 797, 701 | ESIMSm/z 394 [(M+H)+ ] | 1 H NMR(600 MHz, CDCl3 ) δ 7.75 - 7.70 (m, 1H), 7.63 (d,J = 7.5 Hz, 1H), 7.61 - 7.55 (m, 2H), 7.54 - 7.46 (m, 2H), 7.16 (d,J = 8.1 Hz, 1H), 7.06 (dd,J = 8.1, 2.5 Hz, 1H), 5.41 - 5.33 (m, 2H), 3.66 - 3.21 (m, 2H), 2.99 (s, 3H), 2.91 (q,J = 7.5 Hz, 2H), 1.19 (dt,J = 9.1, 7.3 Hz, 6H)。 19 F NMR (564 MHz, CDCl3 ) δ - 62.63。 | |
217 | (薄膜)2968, 2932, 1708, 1632, 1586, 1329, 1231, 1108, 773, 701 | ESIMSm/z 394 [(M+H)+ ] | 1 H NMR(600 MHz, CDCl3 ) δ 7.89 (d,J = 2.1 Hz, 1H), 7.83 (dd,J = 8.2, 2.1 Hz, 1H), 7.71 (s, 1H), 7.62 (d,J = 7.7 Hz, 1H), 7.56 (d,J = 7.7 Hz, 1H), 7.53 - 7.39 (m, 2H), 6.77 (d,J = 8.1 Hz, 1H), 5.37 (s, 2H), 3.52 (s, 1H), 3.29 (s, 1H), 3.00 (s, 3H), 2.74 (q,J = 7.5 Hz, 2H), 1.20 (td,J = 7.3, 3.4 Hz, 6H)。 19 F NMR (564 MHz, CDCl3 ) δ - 62.57。 | |
218 | ESIMSm/z 367 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.78 (s, 1H), 7.35 (d,J = 7.9 Hz, 2H), 7.19 (d,J = 7.8 Hz, 2H), 6.47 (s, 1H), 5.26 (s, 2H), 3.43 (q,J = 7.1 Hz, 2H), 2.99 (s, 3H), 2.53 (s, 3H), 2.36 (s, 3H), 2.16 (q,J = 7.6 Hz, 2H), 2.03 (s, 3H), 1.18 (t,J = 7.1 Hz, 3H), 0.96 (t,J = 7.6 Hz, 3H)。 | ||
219 | ESIMSm/z 421 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.80 (s, 1H), 7.71 (s, 1H), 7.65 (d,J = 7.7 Hz, 1H), 7.59 (d,J = 7.8 Hz, 1H), 7.51 (d,J = 7.7 Hz, 1H), 6.49 (s, 1H), 5.35 (s, 2H), 3.44 (q,J = 7.0 Hz, 2H), 3.00 (s, 3H), 2.53 (s, 3H), 2.18 (q,J = 7.6 Hz, 2H), 2.05 (s, 3H), 1.19 (t,J = 7.1 Hz, 3H), 0.98 (t,J = 7.6 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 62.63。 | ||
220 | 103-105 | 1 H NMR(500 MHz, CDCl3 ) δ 7.70 (s, 1H), 7.48 (s, 1H), 7.16 (dd,J = 8.1, 6.9 Hz, 1H), 7.07 (d,J = 7.5 Hz, 2H), 6.55 (s, 1H), 5.36 (s, 2H), 3.41 (d,J = 91.3 Hz, 2H), 3.00 (s, 3H), 2.53 (s, 3H), 2.44 (s, 6H), 2.20 (s, 3H), 1.22 (q,J = 7.6 Hz, 3H)。 13 C NMR (126 MHz, CDCl3 ) δ 167.80, 154.59, 151.78, 139.52, 138.45, 132.80, 132.64, 128.81, 128.47, 128.22, 122.40, 121.98, 60.88, 47.87, 31.98, 21.82, 19.77, 17.39, 14.31。 | ||
221 | ESIMSm/z 391 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.78 (s, 1H), 7.48 (s, 1H), 7.26 - 7.21 (m, 1H), 6.71 (dd,J = 12.0, 6.5 Hz, 1H), 6.58 (s, 1H), 5.27 (s, 2H), 3.82 (s, 3H), 3.42 (d,J = 95.8 Hz, 2H), 3.02 (s, 3H), 2.54 (s, 3H), 2.24 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 136.21 (dt,J = 21.7, 10.2 Hz), - 148.49 - - 149.06 (m)。 | ||
222 | (薄膜)2920, 1707, 1634, 1576, 1366, 1255, 1142, 1064, 780 | 對於C20 H25 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為325.1911;實測值為325.1918 | 1 H NMR(400 MHz, CDCl3 ) δ 7.66 (d,J = 8.3 Hz, 1H), 7.38 (s, 1H), 7.34 (d,J = 8.1 Hz, 2H), 7.18 (d,J = 7.9 Hz, 2H), 6.59 (d,J = 8.3 Hz, 1H), 5.27 (s, 2H), 3.03 (s, 6H), 2.51 (s, 3H), 2.36 (s, 3H), 2.27 (s, 3H)。 | |
223 | (薄膜)2971, 2926, 1708, 1626, 1576, 1250, 1142, 1067, 806 | 對於C22 H29 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為353.2224;實測值為353.2233 | 1 H NMR(400 MHz, CDCl3 ) δ 7.67 (d,J = 8.3 Hz, 1H), 7.51 (s, 1H), 7.34 (d,J = 8.0 Hz, 2H), 7.18 (d,J = 7.8 Hz, 2H), 6.60 (d,J = 8.4 Hz, 1H), 5.27 (s, 2H), 3.65 (s, 1H), 2.93 (s, 3H), 2.51 (s, 3H), 2.36 (s, 3H), 2.27 (s, 3H), 1.24 (d,J = 6.7 Hz, 6H)。 | |
224 | (薄膜)2948, 2872, 1707, 1627, 1575, 1366, 1235, 1142, 1067, 806 | 對於C22 H27 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為351.2067;實測值為351.2075 | 1 H NMR(400 MHz, CDCl3 ) δ 7.66 (d,J = 8.3 Hz, 1H), 7.63 (s, 1H), 7.34 (d,J = 8.0 Hz, 2H), 7.18 (d,J = 7.8 Hz, 2H), 6.61 (d,J = 8.3 Hz, 1H), 5.26 (s, 2H), 3.52 (s, 4H), 2.51 (s, 3H), 2.36 (s, 3H), 2.28 (s, 3H), 1.96 (s, 4H)。 | |
225 | (薄膜)2936, 2854, 1708, 1627, 1575, 1446, 1366, 1254, 1142, 1061, 777 | 對於C23 H29 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為365.2224;實測值為365.2232 | 1 H NMR(400 MHz, CDCl3 ) δ 7.66 (d,J = 8.4 Hz, 1H), 7.37 (s, 1H), 7.34 (d,J = 7.9 Hz, 2H), 7.18 (d,J = 7.8 Hz, 2H), 6.61 (d,J = 8.4 Hz, 1H), 5.26 (s, 2H), 3.51 (s, 4H), 2.51 (s, 3H), 2.36 (s, 3H), 2.26 (s, 3H), 1.75 - 1.58 (m, 6H)。 | |
226 | (薄膜)2923, 1711, 1636, 1577, 1330, 1255, 1125, 1065, 779 | 對於C20 H22 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為379.1628;實測值為379.1637 | 1 H NMR(400 MHz, CDCl3 ) δ 7.71 - 7.67 (m, 2H), 7.63 (d,J = 7.7 Hz, 1H), 7.59 (d,J = 7.8 Hz, 1H), 7.50 (t,J = 7.7 Hz, 1H), 7.40 (s, 1H), 6.63 (d,J = 8.3 Hz, 1H), 5.35 (s, 2H), 3.04 (s, 6H), 2.52 (s, 3H), 2.28 (s, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 62.63。 | |
227 | (薄膜)2973, 2932, 1711, 1627, 1576, 1330, 1250, 1126, 1071, 779 | 對於C22 H26 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為407.1941;實測值為407.1951 | 1 H NMR(400 MHz, CDCl3 ) δ 7.71 - 7.67 (m, 2H), 7.63 (d,J = 7.7 Hz, 1H), 7.59 (d,J = 7.9 Hz, 1H), 7.54 - 7.47 (m, 2H), 6.63 (d,J = 8.4 Hz, 1H), 5.35 (s, 2H), 3.65 (s, 1H), 2.94 (s, 3H), 2.52 (s, 3H), 2.28 (s, 3H), 1.25 (d,J = 6.7 Hz, 6H)。 19 F NMR (376 MHz, CDCl3 ) δ - 62.63。 | |
228 | (薄膜)2950, 2873, 1710, 1628, 1576, 1331, 1236, 1125, 1070, 800 | 對於C22 H24 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為405.1784;實測值為405.1794 | 1 H NMR(400 MHz, CDCl3 ) δ 7.71 - 7.67 (m, 2H), 7.66 - 7.62 (m, 2H), 7.59 (d,J = 7.8 Hz, 1H), 7.50 (t,J = 7.7 Hz, 1H), 6.64 (d,J = 8.4 Hz, 1H), 5.35 (s, 2H), 3.53 (s, 4H), 2.52 (s, 3H), 2.29 (s, 3H), 1.97 (s, 4H)。 19 F NMR (376 MHz, CDCl3 ) δ - 62.62。 | |
229 | (薄膜)2939, 2856, 1711, 1629, 1576, 1330, 1255, 1123, 1073, 777 | 對於C23 H26 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為419.1941;實測值為419.1952 | 1 H NMR(400 MHz, CDCl3 ) δ 7.73 - 7.66 (m, 2H), 7.63 (d,J = 7.7 Hz, 1H), 7.59 (d,J = 7.8 Hz, 1H), 7.50 (t,J = 7.7 Hz, 1H), 7.38 (s, 1H), 6.64 (d,J = 8.4 Hz, 1H), 5.35 (s, 2H), 3.52 (s, 4H), 2.52 (s, 3H), 2.27 (s, 3H), 1.74 - 1.58 (m, 6H)。 19 F NMR (376 MHz, CDCl3 ) δ - 62.63。 | |
230 | (薄膜)2976, 2929, 1709, 1632, 1577, 1251, 1147, 1061, 779 | 對於C22 H29 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為353.2224;實測值為353.2234 | 1 H NMR(500 MHz, CDCl3 ) δ 7.66 (d,J = 8.3 Hz, 1H), 7.41 (s, 1H), 7.34 (d,J = 8.1 Hz, 2H), 7.16 (d,J = 7.9 Hz, 2H), 6.61 (d,J = 8.3 Hz, 1H), 6.06 (q,J = 6.6 Hz, 1H), 3.59 - 3.23 (m, 2H), 3.02 (s, 3H), 2.48 (s, 3H), 2.34 (s, 3H), 2.26 (s, 3H), 1.63 (d,J = 6.6 Hz, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 | |
231 | (薄膜)2975, 2929, 1709, 1632, 1577, 1252, 1147, 1063, 779 | 對於C22 H29 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為353.2224;實測值為353.2232 | 1 H NMR(500 MHz, CDCl3 ) δ 7.68 (d,J = 8.3 Hz, 1H), 7.42 (s, 1H), 7.25 - 7.22 (m, 3H), 7.12 - 7.08 (m, 1H), 6.62 (d,J = 8.3 Hz, 1H), 6.05 (q,J = 6.6 Hz, 1H), 3.59 - 3.23 (m, 2H), 3.02 (s, 3H), 2.49 (s, 3H), 2.36 (s, 3H), 2.26 (s, 3H), 1.63 (d,J = 6.6 Hz, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 | |
232 | (薄膜)2976, 2930, 1710, 1632, 1577, 1253, 1149, 1062, 910, 733 | 對於C22 H29 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為353.2224;實測值為353.2233 | 1 H NMR(500 MHz, CDCl3 ) δ 7.69 (d,J = 8.4 Hz, 1H), 7.50 (dd,J = 7.5, 1.6 Hz, 1H), 7.42 (s, 1H), 7.25 - 7.15 (m, 3H), 6.62 (d,J = 8.3 Hz, 1H), 6.28 (q,J = 6.5 Hz, 1H), 3.58 - 3.24 (m, 2H), 3.02 (s, 3H), 2.49 (s, 3H), 2.44 (s, 3H), 2.26 (s, 3H), 1.61 (d,J = 6.6 Hz, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 | |
233 | (薄膜)2932, 2872, 1709, 1632, 1577, 1252, 1147, 1063, 779 | 對於C24 H33 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為381.2537;實測值為381.2546 | 1 H NMR(500 MHz, CDCl3 ) δ 7.67 (d,J = 8.3 Hz, 1H), 7.41 (s, 1H), 7.30 (d,J = 8.0 Hz, 2H), 7.15 (d,J = 7.9 Hz, 2H), 6.61 (d,J = 8.3 Hz, 1H), 5.91 (dd,J = 7.6, 6.2 Hz, 1H), 3.60 - 3.23 (m, 2H), 3.02 (s, 3H), 2.47 (s, 3H), 2.33 (s, 3H), 2.26 (s, 3H), 2.01 (dddd,J = 13.2, 10.0, 7.6, 5.4 Hz, 1H), 1.83 (ddt,J = 13.6, 10.0, 6.0 Hz, 1H), 1.49 - 1.30 (m, 2H), 1.22 (t,J = 7.1 Hz, 3H), 0.94 (t,J = 7.4 Hz, 3H)。 | |
234 | (薄膜)2963, 2928, 1712, 1633, 1577, 1364, 1251, 1148, 1064, 812 | 對於C24 H33 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為381.2537;實測值為381.2545 | 1 H NMR(500 MHz, CDCl3 ) δ 7.72 (d,J = 8.3 Hz, 1H), 7.42 (s, 1H), 7.26 - 7.24 (m, 2H), 7.13 (d,J = 7.9 Hz, 2H), 6.63 (d,J = 8.2 Hz, 1H), 5.66 (d,J = 7.2 Hz, 1H), 3.64 - 3.22 (m, 2H), 3.02 (s, 3H), 2.47 (s, 3H), 2.32 (s, 3H), 2.26 (s, 3H), 2.19 (h,J = 6.8 Hz, 1H), 1.22 (t,J = 7.2 Hz, 3H), 1.03 (d,J = 6.6 Hz, 3H), 0.88 (d,J = 6.7 Hz, 3H)。 | |
235 | (薄膜)2972, 2922, 1708, 1631, 1576, 1251, 1146, 1064, 1020, 778 | 對於C24 H31 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為379.238;實測值為379.2388 | 1 H NMR(500 MHz, CDCl3 ) δ 7.69 (d,J = 8.2 Hz, 1H), 7.41 (s, 1H), 7.36 (d,J = 8.1 Hz, 2H), 7.16 (d,J = 7.7 Hz, 2H), 6.62 (d,J = 8.3 Hz, 1H), 5.42 (d,J = 8.5 Hz, 1H), 3.62 - 3.21 (m, 2H), 3.02 (s, 3H), 2.49 (s, 3H), 2.34 (s, 3H), 2.26 (s, 3H), 1.46 - 1.35 (m, 1H), 1.22 (t,J = 7.2 Hz, 3H), 0.71 - 0.55 (m, 3H), 0.49 - 0.38 (m, 1H)。 | |
236 | (薄膜)2973, 2930, 1711, 1632, 1576, 1249, 1142, 1064, 1027, 777 | 對於C27 H31 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為415.238;實測值為415.2391 | 1 H NMR(500 MHz, CDCl3 ) δ 7.79 (d,J = 8.4 Hz, 1H), 7.42 (d,J = 7.2 Hz, 2H), 7.36 - 7.30 (m, 4H), 7.29 - 7.24 (m, 2H), 7.14 (d,J = 7.8 Hz, 2H), 7.04 (s, 1H), 6.63 (d,J = 8.3 Hz, 1H), 3.62 - 3.25 (m, 2H), 3.02 (s, 3H), 2.49 (s, 3H), 2.32 (s, 3H), 2.27 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 | |
237 | (薄膜)2932, 1713, 1633, 1577, 1364, 1252, 1145, 1064, 918, 736 | 對於C24 H30 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為435.2254;實測值為435.2263 | 1 H NMR(500 MHz, CDCl3 ) δ 7.69 (d,J = 8.3 Hz, 1H), 7.47 - 7.39 (m, 1H), 7.30 (d,J = 8.1 Hz, 2H), 7.17 (d,J = 7.8 Hz, 2H), 6.63 (d,J = 8.3 Hz, 1H), 6.02 - 5.85 (m, 1H), 3.60 - 3.28 (m, 2H), 3.02 (s, 3H), 2.48 (s, 3H), 2.34 (s, 3H), 2.26 (s, 3H), 2.26 - 2.10 (m, 4H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 66.32。 | |
238 | 133-136 | 對於C20 H25 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為357.1631;實測值為357.1632 | 1 H NMR(500 MHz, CDCl3 ) δ 7.68 (d,J = 8.4 Hz, 1H), 7.32 (d,J = 7.8 Hz, 2H), 7.19 (d,J = 7.8 Hz, 2H), 7.03 (d,J = 8.4 Hz, 1H), 6.80 (s, 1H), 5.28 (s, 2H), 3.31 (s, 6H), 2.51 (s, 3H), 2.36 (s, 3H), 2.21 (s, 3H)。 | |
239 | 84-87 | 對於C20 H22 F3 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為411.1349;實測值為411.1352 | 1 H NMR(500 MHz, CDCl3 ) δ 7.73 - 7.67 (m, 2H), 7.66 - 7.57 (m, 2H), 7.51 (dd,J = 9.4, 6.2 Hz, 1H), 7.07 (d,J = 8.5 Hz, 1H), 6.80 (s, 1H), 5.37 (s, 2H), 3.32 (s, 6H), 2.52 (s, 3H), 2.22 (s, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 62.65。 | |
240 | 110-112 | 對於C22 H29 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為385.1944;實測值為385.1951 | 1 H NMR(500 MHz, CDCl3 ) δ 7.68 (d,J = 8.4 Hz, 1H), 7.33 (d,J = 8.0 Hz, 2H), 7.19 (d,J = 7.7 Hz, 2H), 7.01 (d,J = 8.4 Hz, 1H), 6.75 (s, 1H), 5.39 (s, 1H), 5.28 (s, 2H), 2.95 (s, 3H), 2.51 (s, 3H), 2.36 (s, 3H), 2.20 (s, 3H), 1.23 (d,J = 6.7 Hz, 6H)。 | |
241 | 100-103 | 對於C22 H26 F3 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為439.1662;實測值為439.1674 | 1 H NMR(500 MHz, CDCl3 ) δ 7.72 - 7.67 (m, 2H), 7.61 (dd,J = 12.5, 7.7 Hz, 2H), 7.51 (dd,J = 9.9, 5.5 Hz, 1H), 7.06 (d,J = 8.4 Hz, 1H), 6.76 (s, 1H), 5.45 - 5.34 (m, 3H), 2.97 (s, 3H), 2.52 (s, 3H), 2.22 (s, 3H), 1.24 (d,J = 6.7 Hz, 6H)。 19 F NMR (471 MHz, CDCl3 ) δ - 62.65。 | |
242 | 169-172 | 對於C22 H27 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為383.1788;實測值為383.1792 | 1 H NMR(500 MHz, CDCl3 ) δ 7.68 (d,J = 8.4 Hz, 1H), 7.32 (d,J = 7.7 Hz, 2H), 7.21 - 7.16 (m, 3H), 6.70 (s, 1H), 5.28 (s, 2H), 4.04 - 3.35 (m, 4H), 2.51 (s, 3H), 2.36 (s, 3H), 2.22 (s, 3H), 2.10 - 1.94 (m, 4H)。 | |
243 | 139-142 | 對於C22 H24 F3 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為437.1505;實測值為437.1512 | 1 H NMR(500 MHz, CDCl3 ) δ 7.74 - 7.67 (m, 2H), 7.66 - 7.57 (m, 2H), 7.55 - 7.47 (m, 1H), 7.23 (d,J = 8.5 Hz, 1H), 6.70 (s, 1H), 5.37 (s, 2H), 4.06 - 3.38 (m, 4H), 2.51 (d,J = 3.0 Hz, 3H), 2.24 (s, 3H), 2.13 - 1.96 (m, 4H)。 19 F NMR (471 MHz, CDCl3 ) δ - 62.65。 | |
244 | 136-139 | 對於C23 H29 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為397.1944;實測值為397.1951 | 1 H NMR(500 MHz, CDCl3 ) δ 7.67 (d,J = 8.4 Hz, 1H), 7.33 (d,J = 7.9 Hz, 2H), 7.19 (d,J = 7.8 Hz, 2H), 6.92 (d,J = 8.5 Hz, 1H), 6.82 (s, 1H), 5.28 (s, 2H), 3.74 - 3.66 (m, 4H), 2.51 (s, 3H), 2.36 (s, 3H), 2.20 (s, 3H), 1.68 - 1.60 (m, 6H)。 | |
245 | 106-109 | 對於C23 H26 F3 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為451.1662;實測值為451.1671 | 1 H NMR(600 MHz, CDCl3 ) δ 7.73 - 7.68 (m, 2H), 7.63 (d,J = 7.7 Hz, 1H), 7.60 (d,J = 7.8 Hz, 1H), 7.51 (t,J = 7.7 Hz, 1H), 6.96 (d,J = 8.5 Hz, 1H), 6.82 (s, 1H), 5.37 (s, 2H), 3.77 - 3.69 (m, 4H), 2.52 (s, 3H), 2.22 (s, 3H), 1.69 - 1.63 (m, 6H)。 19 F NMR (564 MHz, CDCl3 ) δ - 62.66。 | |
246 | (薄膜)3031, 2931, 1707, 1628, 1573, 1366, 1249, 1140, 1063, 1025, 970, 777 | 對於C19 H24 N3 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為326.1863;實測值為326.1868 | 1 H NMR(600 MHz, CDCl3 ) δ 8.72 (dd,J = 2.2, 0.8 Hz, 1H), 8.58 (dd,J = 4.8, 1.7 Hz, 1H), 7.80 - 7.75 (m, 1H), 7.67 (d,J = 8.3 Hz, 1H), 7.46 - 7.41 (m, 1H), 7.31 (ddd,J = 7.8, 4.9, 0.9 Hz, 1H), 6.61 (d,J = 8.3 Hz, 1H), 5.32 (s, 2H), 3.60 - 3.22 (m, 2H), 3.02 (s, 3H), 2.52 (s, 3H), 2.27 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 | |
247 | (薄膜)2930, 1710, 1628, 1572, 1365, 1249, 1139, 1063, 971, 777 | 對於C19 H24 N3 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為326.1863;實測值為326.1870 | 1 H NMR(600 MHz, CDCl3 ) δ 8.64 - 8.59 (m, 2H), 7.74 (d,J = 8.3 Hz, 1H), 7.46 (d,J = 10.6 Hz, 1H), 7.36 - 7.31 (m, 2H), 6.64 (d,J = 8.3 Hz, 1H), 5.32 (s, 2H), 3.62 - 3.22 (m, 2H), 3.03 (s, 3H), 2.53 (s, 3H), 2.29 (s, 3H), 1.23 (t,J = 7.2 Hz, 3H)。 | |
248 | (薄膜)2931, 1710, 1627, 1572, 1364, 1249, 1139, 1065, 972, 777 | 對於C18 H23 N4 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為327.1816;實測值為327.1824 | 1 H NMR(600 MHz, CDCl3 ) δ 9.30 - 9.27 (m, 1H), 9.19 (dd,J = 5.3, 1.3 Hz, 1H), 7.74 (d,J = 8.4 Hz, 1H), 7.56 - 7.50 (m, 1H), 7.47 (s, 1H), 6.65 (d,J = 8.4 Hz, 1H), 5.35 (s, 2H), 3.61 - 3.25 (m, 2H), 3.04 (s, 3H), 2.53 (s, 3H), 2.29 (s, 3H), 1.23 (t,J = 7.2 Hz, 3H)。 | |
249 | (薄膜)2919, 2876, 1706, 1628, 1573, 1364, 1248, 1137, 1062, 1025, 966, 778 | 對於C19 H25 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為345.1631;實測值為345.1641 | 1 H NMR(600 MHz, CDCl3 ) δ 7.64 (d,J = 8.3 Hz, 1H), 7.42 (s, 1H), 6.92 (d,J = 3.4 Hz, 1H), 6.63 (dq,J = 3.4, 1.1 Hz, 1H), 6.59 (d,J = 8.3 Hz, 1H), 5.36 (s, 2H), 3.68 - 3.15 (m, 2H), 3.01 (s, 3H), 2.51 (s, 3H), 2.47 (d,J = 1.1 Hz, 3H), 2.26 (s, 3H), 1.21 (t,J = 7.2 Hz, 3H)。 | |
250 | (薄膜)2931, 1708, 1628, 1573, 1485, 1364, 1245, 1140, 1063, 970, 828 | 對於C19 H23 FN3 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為344.1769;實測值為344.1778 | 1 H NMR(600 MHz, CDCl3 ) δ 8.32 (dt,J = 2.9, 0.8 Hz, 1H), 7.90 (ddd,J = 8.4, 7.6, 2.5 Hz, 1H), 7.65 (d,J = 8.3 Hz, 1H), 7.47 - 7.36 (m, 1H), 6.95 (ddd,J = 8.4, 3.0, 0.7 Hz, 1H), 6.61 (d,J = 8.3 Hz, 1H), 5.30 (s, 2H), 3.59 - 3.26 (m, 2H), 3.02 (s, 3H), 2.51 (s, 3H), 2.27 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (564 MHz, CDCl3 ) δ - 68.52。 | |
251 | (薄膜)2932, 1709, 1628, 1573, 1433, 1365, 1248, 1139, 1063, 971, 876, 778 | 對於C19 H23 FN3 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為344.1769;實測值為344.1777 | 1 H NMR(600 MHz, CDCl3 ) δ 8.54 - 8.51 (m, 1H), 8.44 (d,J = 2.8 Hz, 1H), 7.68 (d,J = 8.4 Hz, 1H), 7.51 (ddd,J = 9.0, 2.7, 1.8 Hz, 1H), 7.45 (s, 1H), 6.62 (d,J = 8.4 Hz, 1H), 5.34 (s, 2H), 3.62 - 3.23 (m, 2H), 3.02 (s, 3H), 2.52 (s, 3H), 2.28 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 | |
252 | 73-76 | 對於C20 H23 F3 N3 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為394.1737;實測值為394.1748 | 1 H NMR(600 MHz, CDCl3 ) δ 8.82 (d,J = 2.1 Hz, 1H), 7.98 - 7.93 (m, 1H), 7.72 - 7.67 (m, 2H), 7.45 (s, 1H), 6.62 (d,J = 8.4 Hz, 1H), 5.39 (s, 2H), 3.63 - 3.23 (m, 2H), 3.03 (s, 3H), 2.52 (s, 3H), 2.28 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (564 MHz, CDCl3 ) δ - 67.90。 | |
253 | (薄膜)2933, 1710, 1630, 1574, 1366, 1249, 1131, 1087, 971, 889 | 對於C20 H23 F3 N3 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為394.1737;實測值為394.1747 | 1 H NMR(600 MHz, CDCl3 ) δ 8.90 (d,J = 2.1 Hz, 1H), 8.86 (dd,J = 2.2, 1.0 Hz, 1H), 8.01 (ddq,J = 2.3, 1.6, 0.7 Hz, 1H), 7.68 (d,J = 8.4 Hz, 1H), 7.45 (s, 1H), 6.63 (d,J = 8.4 Hz, 1H), 5.38 (s, 2H), 3.64 - 3.22 (m, 2H), 3.02 (s, 3H), 2.52 (s, 3H), 2.28 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (564 MHz, CDCl3 ) δ - 62.43。 | |
254 | 84-87 | 對於C19 H23 FN3 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為344.1769;實測值為344.1778 | 1 H NMR(600 MHz, CDCl3 ) δ 8.21 (dd,J = 5.2, 0.8 Hz, 1H), 7.75 (d,J = 8.3 Hz, 1H), 7.47 (s, 1H), 7.21 (ddt,J = 4.0, 2.0, 1.0 Hz, 1H), 7.01 - 6.97 (m, 1H), 6.66 (d,J = 8.4 Hz, 1H), 5.34 (d,J = 0.8 Hz, 2H), 3.65 - 3.24 (m, 2H), 3.03 (s, 3H), 2.54 (s, 3H), 2.29 (s, 3H), 1.23 (t,J = 7.2 Hz, 3H)。 19 F NMR (564 MHz, CDCl3 ) δ - 67.58。 | |
255 | 57-59 | 對於C20 H23 F3 N3 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為394.1737;實測值為394.1747 | 1 H NMR(600 MHz, CDCl3 ) δ 8.73 (d,J = 5.0 Hz, 1H), 7.77 - 7.71 (m, 2H), 7.56 - 7.51 (m, 1H), 7.47 (s, 1H), 6.66 (d,J = 8.4 Hz, 1H), 5.39 (s, 2H), 3.60 - 3.23 (m, 2H), 3.03 (s, 3H), 2.54 (s, 3H), 2.30 (s, 3H), 1.23 (t,J = 7.2 Hz, 3H)。 19 F NMR (564 MHz, CDCl3 ) δ - 68.04。 | |
256 | (薄膜)2924, 2851, 1707, 1630, 1576, 1251, 1145, 1064, 779 | 對於C20 H31 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為331.2380;實測值為331.2388 | 1 H NMR(400 MHz, CDCl3 ) δ 7.63 (d,J = 8.3 Hz, 1H), 7.42 (s, 1H), 6.62 (d,J = 8.3 Hz, 1H), 4.07 (d,J = 6.4 Hz, 2H), 3.56 - 3.24 (m, 2H), 3.02 (s, 3H), 2.51 (s, 3H), 2.27 (s, 3H), 1.89 - 1.64 (m, 6H), 1.39 - 1.00 (m, 8H)。 | |
257 | (薄膜)2930, 1726, 1630, 1573, 1250, 1193, 1122, 1061, 773 | 對於C19 H23 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為311.1754;實測值為311.1763 | 1 H NMR(400 MHz, CDCl3 ) δ 7.92 (d,J = 8.4 Hz, 1H), 7.48 (s, 1H), 7.44 - 7.39 (m, 2H), 7.25 - 7.18 (m, 3H), 6.70 (d,J = 8.4 Hz, 1H), 3.67 - 3.27 (m, 2H), 3.04 (s, 3H), 2.59 (s, 3H), 2.32 (s, 3H), 1.24 (t,J = 7.1 Hz, 3H)。 | |
258 | (薄膜)2924, 1724, 1630, 1575, 1508, 1251, 1195, 1124, 1061, 773 | 對於C20 H25 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為325.1911;實測值為325.1919 | 1 H NMR(400 MHz, CDCl3 ) δ 7.90 (d,J = 8.4 Hz, 1H), 7.47 (s, 1H), 7.24 - 7.17 (m, 2H), 7.11 - 7.04 (m, 2H), 6.69 (d,J = 8.4 Hz, 1H), 3.67 - 3.28 (m, 2H), 3.04 (s, 3H), 2.58 (s, 3H), 2.36 (s, 3H), 2.31 (s, 3H), 1.24 (t,J = 7.1 Hz, 3H)。 | |
259 | (薄膜)2973, 2932, 1709, 1611, 1580, 1246, 1140, 1081, 841 | 對於C23 H31 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為367.238;實測值為367.2389 | 1 H NMR(400 MHz, CDCl3 ) δ 7.65 (d,J = 8.3 Hz, 1H), 7.35 (d,J = 8.0 Hz, 2H), 7.18 (d,J = 7.4 Hz, 2H), 6.48 (d,J = 8.3 Hz, 1H), 5.26 (s, 2H), 3.44 (q,J = 7.0 Hz, 2H), 3.00 (s, 3H), 2.51 (s, 3H), 2.36 (s, 3H), 2.13 (q,J = 7.6 Hz, 2H), 2.05 (s, 3H), 1.19 (t,J = 7.0 Hz, 3H), 0.94 (t,J = 7.6 Hz, 3H)。 | |
260 | (薄膜)2943, 2863, 1708, 1613, 1579, 1286, 1247, 1139, 1045, 839 | 112-115 | 對於C23 H29 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為365.2224;實測值為365.2231 | 1 H NMR(400 MHz, CDCl3 ) δ 7.64 (d,J = 8.3 Hz, 1H), 7.34 (d,J = 8.0 Hz, 2H), 7.18 (d,J = 7.5 Hz, 2H), 6.50 (d,J = 8.3 Hz, 1H), 5.26 (s, 2H), 3.27 (t,J = 6.1 Hz, 2H), 3.03 (s, 3H), 2.51 (s, 3H), 2.36 (s, 3H), 2.07 - 2.01 (m, 5H), 1.84 - 1.75 (m, 2H), 1.65 - 1.57 (m, 2H)。 |
261 | 對於C23 H28 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為421.2097;實測值為421.2107 | 1 H NMR(400 MHz, CDCl3 ) δ 7.73 - 7.62 (m, 3H), 7.59 (d,J = 7.8 Hz, 1H), 7.50 (t,J = 7.7 Hz, 1H), 6.51 (d,J = 8.3 Hz, 1H), 5.35 (s, 2H), 3.44 (q,J = 7.0 Hz, 2H), 3.00 (s, 3H), 2.52 (s, 3H), 2.15 (q,J = 7.6 Hz, 2H), 2.06 (s, 3H), 1.19 (t,J = 7.0 Hz, 3H), 0.95 (t,J = 7.6 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 62.63。 | ||
262 | (薄膜)2944, 2864, 1710, 1613, 1578, 1329, 1246, 1125, 1074, 1045, 840 | 對於C23 H26 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為419.1941;實測值為419.1953 | 1 H NMR(400 MHz, CDCl3 ) δ 7.71 - 7.62 (m, 3H), 7.58 (d,J = 7.8 Hz, 1H), 7.50 (t,J = 7.7 Hz, 1H), 6.53 (d,J = 8.4 Hz, 1H), 5.34 (s, 2H), 3.27 (t,J = 6.1 Hz, 2H), 3.03 (s, 3H), 2.52 (s, 3H), 2.10 - 2.02 (m, 5H), 1.85 - 1.75 (m, 2H), 1.68 - 1.58 (m, 2H)。 19 F NMR (376 MHz, CDCl3 ) δ - 62.63。 | |
263 | ESIMSm/z 351 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.78 (s, 1H), 7.38 - 7.31 (m, 2H), 7.18 (d,J = 7.8 Hz, 2H), 6.55 (s, 1H), 5.26 (s, 2H), 3.37 (t,J = 6.9 Hz, 2H), 2.97 (s, 3H), 2.52 (s, 3H), 2.36 (s, 3H), 2.22 (t,J = 7.8 Hz, 2H), 2.09 (s, 3H), 1.97 - 1.89 (m, 2H)。 13 C NMR (126 MHz, CDCl3 ) δ 167.56, 161.12, 155.56, 139.18, 137.76, 133.66, 132.88, 129.18, 128.35, 127.44, 124.88, 122.22, 65.94, 51.28, 31.28, 27.63, 21.82, 21.22, 19.72, 17.43。 | ||
264 | ESIMSm/z 405 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.79 (s, 1H), 7.71 (d,J = 2.1 Hz, 1H), 7.64 (d,J = 7.7 Hz, 1H), 7.59 (d,J = 7.8 Hz, 1H), 7.50 (t,J = 7.7 Hz, 1H), 6.57 (s, 1H), 5.35 (s, 2H), 3.38 (t,J = 6.8 Hz, 2H), 2.98 (s, 3H), 2.53 (s, 3H), 2.24 (t,J = 7.8 Hz, 2H), 2.11 (s, 3H), 1.94 (tt,J = 7.6, 6.7 Hz, 2H)。 19 F NMR (471 MHz, CDCl3 ) δ - 62.63。 | ||
265 | ESIMSm/z 419 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.80 (s, 1H), 7.71 (d,J = 1.9 Hz, 1H), 7.64 (d,J = 7.7 Hz, 1H), 7.59 (d,J = 7.8 Hz, 1H), 7.50 (t,J = 7.7 Hz, 1H), 6.51 (s, 1H), 5.35 (s, 2H), 3.27 (t,J = 6.1 Hz, 2H), 3.02 (s, 3H), 2.53 (s, 3H), 2.10 (t,J = 6.6 Hz, 2H), 2.06 (s, 3H), 1.84 - 1.78 (m, 2H), 1.67 - 1.61 (m, 2H)。 19 F NMR (471 MHz, CDCl3 ) δ - 62.63。 | ||
266 | ESIMSm/z 326 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 8.64 - 8.58 (m, 2H), 7.84 (s, 1H), 7.47 (d,J = 24.1 Hz, 1H), 7.36 - 7.31 (m, 2H), 6.60 (s, 1H), 5.32 (s, 2H), 3.43 (d,J = 96.9 Hz, 2H), 3.02 (s, 3H), 2.56 (s, 3H), 2.26 (s, 3H), 1.23 (t,J = 7.2 Hz, 3H)。 13 C NMR (126 MHz, CDCl3 ) δ 166.91, 155.09, 151.99, 150.02, 145.80, 140.01, 132.79, 129.07, 122.05, 121.90, 121.55, 64.01, 47.90, 32.00, 21.91, 17.52, 14.35。 | ||
267 | 88-90 | ESIMSm/z 394 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 8.73 (d,J = 5.0 Hz, 1H), 7.84 (s, 1H), 7.73 (d,J = 1.6 Hz, 1H), 7.54 (dd,J = 5.0, 1.5 Hz, 1H), 7.52 - 7.42 (m, 1H), 6.61 (s, 1H), 5.39 (s, 2H), 3.44 (d,J = 98.6 Hz, 2H), 3.03 (s, 3H), 2.56 (s, 3H), 2.27 (s, 3H), 1.23 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 68.04。 | |
268 | ESIMSm/z 344 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 8.33 (d,J = 2.5 Hz, 1H), 7.90 (td,J = 8.0, 2.5 Hz, 1H), 7.75 (s, 1H), 7.45 (d,J = 37.7 Hz, 1H), 6.95 (dd,J = 8.4, 2.9 Hz, 1H), 6.58 (s, 1H), 5.30 (s, 2H), 3.42 (d,J = 96.4 Hz, 2H), 3.02 (s, 3H), 2.54 (s, 3H), 2.23 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 68.55 (d,J = 7.4 Hz)。 | ||
269 | ESIMSm/z 289 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.80 (s, 1H), 7.45 (d,J = 31.4 Hz, 1H), 6.58 (s, 1H), 5.09 - 5.04 (m, 1H), 4.96 (t,J = 1.5 Hz, 1H), 4.69 (s, 2H), 3.42 (d,J = 91.6 Hz, 2H), 3.02 (s, 3H), 2.56 (s, 3H), 2.25 (s, 3H), 1.84 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 13 C NMR (126 MHz, CDCl3 ) δ 167.29, 154.63, 151.79, 140.56, 139.56, 132.76, 128.84, 122.47, 121.98, 112.59, 67.52, 47.87, 31.93, 21.84, 19.74, 17.49, 14.43。 | ||
270 | ESIMSm/z 275 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.79 (s, 1H), 7.48 (s, 1H), 6.57 (s, 1H), 6.05 (ddt,J = 17.2, 10.9, 5.6 Hz, 1H), 5.40 (dq,J = 17.2, 1.6 Hz, 1H), 5.26 (dq,J = 10.4, 1.4 Hz, 1H), 4.77 (dt,J = 5.6, 1.5 Hz, 2H), 3.42 (d,J = 92.9 Hz, 2H), 3.01 (s, 3H), 2.55 (s, 3H), 2.24 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 13 C NMR (126 MHz, CDCl3 ) δ 167.28, 154.63, 151.80, 139.55, 132.88, 132.75, 128.83, 122.43, 121.98, 117.74, 64.90, 47.86, 31.97, 21.80, 17.46, 14.35。 | ||
271 | ESIMSm/z 329 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.74 (s, 1H), 7.46 (s, 1H), 6.55 (s, 1H), 5.60 (dq,J = 3.3, 1.5 Hz, 1H), 5.44 (dqd,J = 5.7, 4.3, 3.5, 1.6 Hz, 1H), 3.40 (d,J = 79.6 Hz, 2H), 3.01 (s, 3H), 2.54 (s, 3H), 2.24 (s, 3H), 1.99 (tdd,J = 23.1, 17.6, 6.0 Hz, 2H), 1.90 - 1.80 (m, 3H), 1.73 (d,J = 2.5 Hz, 3H), 1.68 (ddt,J = 9.0, 6.4, 3.7 Hz, 1H), 1.22 (t,J = 7.1 Hz, 3H)。 13 C NMR (126 MHz, CDCl3 ) δ 167.59, 154.34, 151.79, 140.45, 139.08, 132.69, 128.70, 123.38, 121.92, 120.69, 68.52, 47.81, 31.92, 30.04, 28.28, 23.79, 21.84, 19.35, 17.43, 14.40。 | ||
272 | ESIMSm/z 332 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.74 (s, 1H), 7.53 - 7.36 (m, 1H), 6.56 (s, 1H), 5.06 (tq,J = 8.5, 4.2 Hz, 1H), 3.42 (d,J = 90.3 Hz, 2H), 3.01 (s, 3H), 2.92 (dd,J = 10.8, 3.8 Hz, 1H), 2.61 (dt,J = 10.4, 4.2 Hz, 1H), 2.53 (s, 3H), 2.31 (s, 3H), 2.30 - 2.26 (m, 1H), 2.24 (s, 3H), 2.14 (q,J = 11.5, 10.6 Hz, 1H), 2.03 (dt,J = 12.9, 4.8 Hz, 1H), 1.87 - 1.79 (m, 1H), 1.72 - 1.64 (m, 1H), 1.54 - 1.46 (m, 1H), 1.22 (t,J = 7.2 Hz, 3H)。 13 C NMR (126 MHz, CDCl3 ) δ 167.07, 154.51, 151.79, 139.23, 132.74, 128.75, 122.94, 121.94, 69.39, 59.51, 55.43, 48.86, 46.34, 32.05, 29.32, 23.08, 21.84, 17.43, 14.32。 | ||
273 | ESIMSm/z 332 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.75 (s, 1H), 7.47 (s, 1H), 6.56 (s, 1H), 5.01 (dh,J = 8.1, 4.3 Hz, 1H), 3.42 (d,J = 93.3 Hz, 2H), 3.01 (s, 3H), 2.77 - 2.67 (m, 2H), 2.54 (s, 3H), 2.31 (d,J = 12.5 Hz, 5H), 2.25 (s, 3H), 2.03 (ddt,J = 13.5, 7.0, 3.2 Hz, 2H), 1.86 (dtd,J = 16.3, 8.0, 3.7 Hz, 2H), 1.22 (t,J = 7.1 Hz, 3H)。 | ||
274 | (薄膜)2972, 2931, 1709, 1630, 1576, 1251, 1144, 1064, 779 | 對於C16 H23 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為275.1754;實測值為275.1760 | 1 H NMR(400 MHz, CDCl3 ) δ 7.67 (d,J = 8.3 Hz, 1H), 7.43 (s, 1H), 6.62 (d,J = 8.4 Hz, 1H), 6.04 (ddt,J = 17.2, 10.5, 5.6 Hz, 1H), 5.40 (dq,J = 17.2, 1.6 Hz, 1H), 5.26 (dq,J = 10.4, 1.4 Hz, 1H), 4.77 (dt,J = 5.6, 1.5 Hz, 2H), 3.62 - 3.24 (m, 2H), 3.02 (s, 3H), 2.51 (s, 3H), 2.28 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 | |
275 | (薄膜)2972, 2930, 2876, 1710, 1630, 1575, 1364, 1253, 1143, 1063, 778 | 對於C17 H25 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為289.1911;實測值為289.1918 | 1 H NMR(400 MHz, CDCl3 ) δ 7.69 (d,J = 8.3 Hz, 1H), 7.43 (s, 1H), 6.62 (d,J = 8.4 Hz, 1H), 5.06 (dd,J = 1.7, 0.9 Hz, 1H), 4.99 - 4.93 (m, 1H), 4.69 (s, 2H), 3.63 - 3.26 (m, 2H), 3.02 (s, 3H), 2.52 (s, 3H), 2.28 (s, 3H), 1.84 (dd,J = 1.5, 0.9 Hz, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 | |
276 | (薄膜)3286, 2972, 2932, 2876, 2127, 1710, 1627, 1572, 1363, 1248, 1137, 1062, 777 | 對於C16 H21 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為273.1598;實測值為273.1603 | 1 H NMR(400 MHz, CDCl3 ) δ 7.70 (d,J = 8.3 Hz, 1H), 7.43 (s, 1H), 6.62 (d,J = 8.4 Hz, 1H), 4.86 (d,J = 2.5 Hz, 2H), 3.58 - 3.25 (m, 2H), 3.02 (s, 3H), 2.52 (s, 3H), 2.48 (t,J = 2.4 Hz, 1H), 2.28 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 | |
277 | (薄膜)2971, 2920, 2239, 1710, 1629, 1574, 1364, 1249, 1139, 1063, 778 | 對於C17 H23 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為287.1754;實測值為287.1761 | 1 H NMR(400 MHz, CDCl3 ) δ 7.69 (d,J = 8.3 Hz, 1H), 7.42 (s, 1H), 6.62 (d,J = 8.3 Hz, 1H), 4.83 (q,J = 2.4 Hz, 2H), 3.58 - 3.25 (m, 2H), 3.02 (s, 3H), 2.52 (s, 3H), 2.27 (s, 3H), 1.87 (t,J = 2.4 Hz, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 | |
278 | (薄膜)2960, 2934, 2184, 1714, 1631, 1576, 1363, 1249, 1138, 1063, 843 | 對於C19 H29 N2 O2 Si計算的HRMS-ESI (m/z ) [M+H]+ 為345.1993;實測值為345.2003 | 1 H NMR(400 MHz, CDCl3 ) δ 7.69 (d,J = 8.3 Hz, 1H), 7.43 (s, 1H), 6.63 (d,J = 8.4 Hz, 1H), 4.87 (s, 2H), 3.59 - 3.27 (m, 2H), 3.02 (s, 3H), 2.51 (s, 3H), 2.27 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H), 0.19 (s, 9H)。 | |
279 | 65-66 | ESIMSm/z 394 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 8.91 (d,J = 2.1 Hz, 1H), 8.89 - 8.85 (m, 1H), 8.01 (d,J = 2.3 Hz, 1H), 7.78 (s, 1H), 7.45 (d,J = 40.3 Hz, 1H), 6.59 (s, 1H), 5.38 (s, 2H), 3.43 (d,J = 95.6 Hz, 2H), 3.02 (s, 3H), 2.55 (s, 3H), 2.24 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 62.42。 | |
280 | ESIMSm/z 345 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.76 (s, 1H), 7.47 (s, 1H), 6.93 (d,J = 3.4 Hz, 1H), 6.63 (dt,J = 3.4, 1.2 Hz, 1H), 6.55 (s, 1H), 5.36 (s, 2H), 3.41 (d,J = 90.9 Hz, 2H), 3.01 (s, 3H), 2.55 (s, 3H), 2.47 (d,J = 1.1 Hz, 3H), 2.22 (s, 3H), 1.21 (t,J = 7.1 Hz, 3H)。 13 C NMR (126 MHz, CDCl3 ) δ 167.32, 154.70, 151.76, 141.33, 139.59, 136.38, 132.88, 128.81, 127.91, 124.76, 122.27, 121.93, 60.68, 47.86, 31.97, 21.85, 17.42, 15.40, 14.44。 | ||
281 | (薄膜)3240, 2929, 1715, 1536, 1330, 1164, 1125, 701 | 對於C21 H25 F3 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為440.1614;實測值為440.1619 | 1 H NMR(400 MHz, CDCl3 ) δ 7.97 (s, 1H), 7.84 (s, 1H), 7.69 (s, 1H), 7.63 (t,J = 6.8 Hz, 2H), 7.53 (t,J = 7.7 Hz, 1H), 7.13 (s, 1H), 5.38 (s, 2H), 3.75 (s, 2H), 3.47 (s, 2H), 2.90 - 2.69 (m, 2H), 2.54 (s, 3H), 2.27 (s, 3H), 1.76 - 1.51 (m, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 62.67。 | |
282 | (薄膜)3254, 2928, 1714, 1532, 1330, 1163, 1124, 701 | 對於C20 H23 F3 N3 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為426.1458;實測值為426.1468 | 1 H NMR(500 MHz, CDCl3 ) δ 7.87 (s, 1H), 7.70 (s, 1H), 7.62 (t,J = 8.2 Hz, 2H), 7.52 (t,J = 7.7 Hz, 1H), 7.18 (s, 1H), 5.38 (s, 2H), 3.62 (d,J = 23.2 Hz, 2H), 3.46 (s, 2H), 3.00 - 2.84 (m, 2H), 2.74 (s, 2H), 2.56 (s, 3H), 2.28 (s, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 62.68。 | |
283 | (薄膜)3222, 2924, 1710, 1518, 1251, 1139, 1045, 807, 731 | 對於C20 H26 N3 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為372.1740;實測值為372.1739 | 1 H NMR(500 MHz, CDCl3 ) δ 7.85 (s, 1H), 7.33 (d,J = 7.7 Hz, 2H), 7.20 (d,J = 7.7 Hz, 2H), 7.14 (d,J = 6.6 Hz, 1H), 5.29 (s, 2H), 3.63 (d,J = 9.8 Hz, 2H), 3.45 (s, 3H), 2.95 - 2.85 (m, 2H), 2.74 (s, 2H), 2.54 (s, 3H), 2.37 (s, 3H), 2.26 (s, 3H)(以NH3 + 鹽形式存在)。 | |
284 | (薄膜)3233, 2925, 1711, 1533, 1245, 1156, 806, 731 | 對於C21 H28 N3 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為386.1897;實測值為386.1900 | 1 H NMR(500 MHz, CDCl3 ) δ 7.82 (s, 1H), 7.33 (dd,J = 7.8, 5.8 Hz, 2H), 7.20 (d,J = 7.8 Hz, 2H), 7.09 (s, 1H), 5.29 (s, 2H), 3.75 (s, 2H), 3.46 (s, 2H), 3.03 - 2.97 (m, 4H), 2.77 (p,J = 6.7, 6.0 Hz, 3H), 2.53 (s, 2H), 2.37 (s, 3H), 2.25 (d,J = 3.3 Hz, 3H)。 | |
285 | (薄膜)2933, 1715, 1630, 1571, 1196, 1175, 1224, | 對於C20 H24 BrN2 O3 計算的HRMS-ESI (m/z ) [M+H]+ 為419.0965;實測值為419.0971 | 1 H NMR(500 MHz, CDCl3 ) δ 8.06 (s, 1H), 7.52 (s, 1H), 7.37 - 7.31 (m, 2H), 7.18 (d,J = 7.8 Hz, 2H), 6.44 (s, 1H), 5.26 (s, 2H), 3.88 (s, 3H), 3.35 (q,J = 7.2 Hz, 2H), 3.07 (s, 3H), 2.36 (s, 3H), 1.26 (t,J = 7.2 Hz, 3H)。 | |
286 | (薄膜)2935, 1717, 1631, 1572, 1329, 1225 | 對於C20 H21 BrF3 N2 O3 計算的HRMS-ESI (m/z ) [M+H]+ 為473.0682;實測值為473.0692 | 1 H NMR(500 MHz, CDCl3 ) δ 8.10 (s, 1H), 7.76 (s, 1H), 7.62 (d,J = 7.7 Hz, 1H), 7.58 (d,J = 7.9 Hz, 1H), 7.54 (s, 1H), 7.50 (t,J = 7.7 Hz, 1H), 6.46 (s, 1H), 5.36 (s, 2H), 3.90 (s, 3H), 3.36 (q,J = 7.2 Hz, 2H), 3.08 (s, 3H), 1.26 (t,J = 7.2 Hz, 3H)。 | |
287 | (薄膜)2935, 1717, 1632, 1574, 1223, 1081 | 對於C19 H21 BrFN2 O3 計算的HRMS-ESI (m/z ) [M+H]+ 為423.0714;實測值為423.072 | 1 H NMR(500 MHz, CDCl3 ) δ 8.06 (s, 1H), 7.53 (s, 1H), 7.45 - 7.41 (m, 2H), 7.13 - 6.97 (m, 2H), 6.45 (s, 1H), 5.26 (s, 2H), 3.89 (s, 3H), 3.36 (q,J = 7.2 Hz, 2H), 3.07 (s, 3H), 1.26 (t,J = 7.2 Hz, 3H)。 | |
288 | (薄膜)2934, 1715, 1628, 1572, 1223, 1073 | 對於C20 H23 BrFN2 O4 計算的HRMS-ESI (m/z ) [M+H]+ 為453.0820;實測值為453.0829 | 1 H NMR(500 MHz, CDCl3 ) δ 8.03 (s, 1H), 7.52 (s, 1H), 7.39 (t,J = 8.5 Hz, 1H), 6.69 (dd,J = 8.5, 2.6 Hz, 1H), 6.65 (dd,J = 11.6, 2.5 Hz, 1H), 6.44 (s, 1H), 5.29 (d,J = 1.0 Hz, 2H), 3.88 (s, 3H), 3.80 (s, 3H), 3.35 (q,J = 7.2 Hz, 2H), 3.07 (s, 3H), 1.26 (t,J = 7.1 Hz, 3H)。 | |
289 | (薄膜)2934, 1719, 1631, 1573, 1226, 1083 | 對於C19 H20 BrClFN2 O3 計算的HRMS-ESI (m/z ) [M+H]+ 為457.0324;實測值為457.0329 | 1 H NMR(500 MHz, CDCl3 ) δ 8.08 (s, 1H), 7.56 - 7.49 (m, 2H), 7.16 (dd,J = 8.5, 2.6 Hz, 1H), 7.00 (td,J = 8.3, 2.6 Hz, 1H), 6.45 (s, 1H), 5.36 (s, 2H), 3.89 (s, 3H), 3.36 (q,J = 7.2 Hz, 2H), 3.08 (s, 3H), 1.26 (t,J = 7.2 Hz, 3H)。 | |
290 | (薄膜)2936, 1709, 1630, 1574, 1225, 1134, 1080 | 對於C22 H28 BrN2 O5 計算的HRMS-ESI (m/z ) [M+H]+ 為479.1176;實測值為479.1184 | 1 H NMR(500 MHz, CDCl3 ) δ 7.94 (s, 1H), 7.50 (s, 1H), 6.42 (s, 1H), 6.40 (s, 3H), 5.36 (s, 2H), 3.86 (s, 3H), 3.81 (s, 6H), 3.34 (q,J = 7.2 Hz, 2H), 3.05 (s, 3H), 2.37 (s, 3H), 1.25 (t,J = 7.2 Hz, 3H)。 | |
291 | (薄膜)2932, 1716, 1632, 1574, 1226, 1079 | 對於C21 H26 BrN2 O3 計算的HRMS-ESI (m/z ) [M+H]+ 為433.1121;實測值為433.1125 | 1 H NMR(500 MHz, CDCl3 ) δ 8.03 (s, 1H), 7.52 (s, 1H), 7.31 (d,J = 7.6 Hz, 1H), 7.04 - 6.99 (m, 2H), 6.44 (s, 1H), 5.27 (s, 2H), 3.88 (s, 3H), 3.35 (q,J = 7.2 Hz, 2H), 3.06 (s, 3H), 2.38 (s, 3H), 2.32 (s, 3H), 1.26 (t,J = 7.2 Hz, 3H)。 | |
292 | (薄膜)2932, 1714, 1630, 1570, 1220, 1074 | 對於C20 H23 BrFN2 O3 計算的HRMS-ESI (m/z ) [M+H]+ 為437.0871;實測值為437.0879 | 1 H NMR(500 MHz, CDCl3 ) δ 7.98 (s, 1H), 7.51 (s, 1H), 7.22 (td,J = 7.9, 5.8 Hz, 1H), 7.00 (d,J = 7.6 Hz, 1H), 6.94 (t,J = 8.9 Hz, 1H), 6.43 (s, 1H), 5.37 (d,J = 1.6 Hz, 2H), 3.86 (s, 3H), 3.34 (q,J = 7.1 Hz, 2H), 3.06 (s, 3H), 2.45 (s, 3H), 1.25 (t,J = 7.2 Hz, 3H)。 | |
293 | ESIMSm/z 397 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.73 - 7.68 (m, 2H), 7.66 (d,J = 7.7 Hz, 1H), 7.58 (d,J = 7.8 Hz, 1H), 7.51 (q,J = 7.7, 7.2 Hz, 2H), 6.59 (d,J = 8.3 Hz, 1H), 5.39 (s, 2H), 3.62 - 3.29 (m, 2H), 3.04 (s, 3H), 2.22 (d,J = 2.9 Hz, 3H), 1.24 (t,J = 7.3 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 62.64, - 110.96。 | ||
294 | ESIMSm/z 397 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.75 - 7.69 (m, 2H), 7.65 (d,J = 7.7 Hz, 1H), 7.58 (d,J = 7.9 Hz, 1H), 7.55 - 7.47 (m, 2H), 6.51 (d,J = 12.6 Hz, 1H), 5.39 (s, 2H), 3.54 (s, 1H), 3.39 - 3.29 (m, 1H), 3.04 (s, 3H), 2.23 (s, 3H), 1.29 - 1.17 (m, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 62.65, - 111.99。 | ||
295 | (薄膜)2979, 2937, 1700, 1586, 1425, 1330, 1246, 1114, 1074, 894, 795 | 對於C19 H18 F5 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為401.1283;實測值為401.1292 | 1 H NMR(600 MHz, CDCl3 ) δ 7.74 - 7.69 (m, 2H), 7.66 - 7.56 (m, 3H), 7.50 (t,J = 7.7 Hz, 1H), 6.69 (ddd,J = 12.2, 10.2, 6.8 Hz, 1H), 5.38 (s, 2H), 3.56 (q,J = 7.2 Hz, 1H), 3.35 (q,J = 7.2 Hz, 1H), 3.05 (s, 2H), 3.03 (s, 1H), 1.24 (t,J = 7.2 Hz, 2H), 1.21 (t,J = 7.2 Hz, 1H)。 | |
296 | (薄膜)2977, 2937, 1714, 1585, 1464, 1330, 1287, 1197, 1118, 1073, 1040, 974, 775 | 對於C19 H18 F5 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為401.1283;實測值為401.1292 | 1 H NMR(600 MHz, CDCl3 ) δ 7.70 (d,J = 12.3 Hz, 2H), 7.63 (d,J = 7.7 Hz, 1H), 7.62 - 7.58 (m, 1H), 7.58 - 7.54 (m, 1H), 7.48 (t,J = 7.7 Hz, 1H), 6.76 - 6.68 (m, 1H), 5.38 (s, 2H), 3.55 (q,J = 7.2 Hz, 1H), 3.33 (q,J = 7.2 Hz, 1H), 3.04 (s, 2H), 3.01 (s, 1H), 1.22 (t,J = 7.2 Hz, 2H), 1.19 (t,J = 7.2 Hz, 1H)。 | |
297 | 126-127 | ESIMSm/z 429 [(M+H)+ ] | 1 H NMR(500 MHz, DMSO-d 6 ) δ 8.92 (s, 1H), 7.85 (s, 1H), 7.80 (d,J = 7.7 Hz, 1H), 7.76 (d,J = 8.1 Hz, 1H), 7.73 (d,J = 7.8 Hz, 1H), 7.66 (t,J = 7.7 Hz, 1H), 7.14 (d,J = 12.0 Hz, 1H), 5.46 (s, 2H), 3.81 (q,J = 7.1 Hz, 2H), 3.22 (s, 3H), 2.19 (s, 3H), 1.15 (t,J = 7.0 Hz, 3H)。 19 F NMR (471 MHz, DMSO-d 6 ) δ - 61.10, - 113.98。 | |
298 | 121-122 | ESIMSm/z 429 [(M+H)+ ] | 1 H NMR(500 MHz, DMSO-d 6 ) δ 9.01 (s, 1H), 7.85 (s, 1H), 7.80 (d,J = 7.7 Hz, 1H), 7.72 (t,J = 8.4 Hz, 2H), 7.67 (t,J = 7.7 Hz, 1H), 7.07 (d,J = 8.4 Hz, 1H), 5.45 (s, 2H), 3.81 (q,J = 7.1 Hz, 2H), 3.23 (s, 3H), 2.09 (d,J = 2.4 Hz, 3H), 1.16 (t,J = 7.0 Hz, 3H)。 19 F NMR (471 MHz, DMSO-d 6 ) δ - 61.08, - 112.36。 | |
299 | ESIMSm/z 343 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.70 (d,J = 8.3 Hz, 1H), 7.45 (d,J = 53.6 Hz, 1H), 7.35 (d,J = 7.7 Hz, 2H), 7.18 (d,J = 7.6 Hz, 2H), 6.48 (d,J = 12.6 Hz, 1H), 5.30 (s, 2H), 3.59 - 3.29 (m, 2H), 3.02 (s, 3H), 2.35 (s, 3H), 2.21 (s, 3H), 1.27 - 1.18 (m, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 112.41。 | ||
300 | ESIMSm/z 397 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.70 (dd,J = 13.2, 4.0 Hz, 3H), 7.63 (d,J = 7.7 Hz, 1H), 7.60 (d,J = 7.5 Hz, 1H), 7.51 (t,J = 7.7 Hz, 1H), 6.80 (d,J = 8.3 Hz, 1H), 5.34 (s, 2H), 3.62 - 3.30 (m, 2H), 3.04 (d,J = 12.7 Hz, 3H), 2.55 (s, 3H), 1.24 (t,J = 7.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 62.66, - 132.80。 | ||
301 | 對於C20 H24 FN2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為343.1816;實測值為343.1819 | 1 H NMR(400 MHz, CDCl3 ) δ 7.68 (d,J = 8.3 Hz, 1H), 7.48 (td,J = 7.5, 1.8 Hz, 1H), 7.44 - 7.36 (m, 1H), 7.32 (tdd,J = 7.4, 5.3, 1.8 Hz, 1H), 7.18 - 7.03 (m, 2H), 6.61 (d,J = 8.4 Hz, 1H), 5.37 (s, 2H), 3.62 - 3.23 (m, 2H), 3.02 (s, 3H), 2.51 (s, 3H), 2.27 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 117.92。 | ||
302 | 對於C20 H24 FN2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為343.1816;實測值為343.1828 | 1 H NMR(400 MHz, CDCl3 ) δ 7.70 (d,J = 8.3 Hz, 1H), 7.47 - 7.38 (m, 1H), 7.33 (td,J = 7.9, 5.8 Hz, 1H), 7.23 - 7.19 (m, 1H), 7.15 (dt,J = 9.8, 2.1 Hz, 1H), 7.01 (ddt,J = 8.9, 7.9, 1.6 Hz, 1H), 6.62 (d,J = 8.4 Hz, 1H), 5.30 (s, 2H), 3.61 - 3.24 (m, 2H), 3.02 (s, 3H), 2.52 (s, 3H), 2.28 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 112.98。 | ||
303 | 對於C20 H24 FN2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為343.1816;實測值為343.1821 | 1 H NMR(400 MHz, CDCl3 ) δ 7.66 (d,J = 8.3 Hz, 1H), 7.45 - 7.35 (m, 3H), 7.09 - 7.02 (m, 2H), 6.60 (d,J = 8.3 Hz, 1H), 5.27 (s, 2H), 3.57 - 3.22 (m, 2H), 3.02 (s, 3H), 2.51 (s, 3H), 2.27 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 114.17。 | ||
304 | ESIMSm/z 343 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.74 - 7.56 (m, 2H), 7.33 (d,J = 7.8 Hz, 2H), 7.19 (d,J = 7.8 Hz, 2H), 6.77 (d,J = 8.3 Hz, 1H), 5.26 (s, 2H), 3.60 - 3.29 (m, 2H), 3.03 (d,J = 13.5 Hz, 3H), 2.54 (s, 3H), 2.36 (s, 3H), 1.23 (t,J = 7.3 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 133.06。 | ||
305 | (薄膜)2927, 1709, 1627, 1572, 1369, 1228, 1079 | 對於C20 H24 BrN2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為403.1016;實測值為403.0994 | 1 H NMR(500 MHz, CDCl3 ) δ 8.17 (s, 1H), 7.53 (s, 1H), 7.33 (d,J = 7.8 Hz, 2H), 7.19 (d,J = 7.7 Hz, 2H), 6.68 (s, 1H), 5.26 (s, 2H), 3.34 (q,J = 7.2 Hz, 2H), 3.06 (s, 3H), 2.53 (s, 3H), 2.36 (s, 3H), 1.25 (t,J = 7.2 Hz, 3H)。 | |
306 | 對於C20 H21 BrF3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為457.0733;實測值為457.0741 | 1 H NMR(500 MHz, CDCl3 ) δ 8.19 (s, 1H), 7.69 (s, 1H), 7.64 (d,J = 7.7 Hz, 1H), 7.60 (d,J = 7.9 Hz, 1H), 7.55 (s, 1H), 7.52 (t,J = 7.7 Hz, 1H), 6.70 (s, 1H), 5.34 (s, 2H), 3.35 (q,J = 7.2 Hz, 2H), 3.07 (s, 3H), 2.54 (s, 3H), 1.25 (t,J = 7.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 62.64。 | ||
307 | 對於C20 H23 BrFN2 O3 計算的HRMS-ESI (m/z ) [M+H]+ 為437.0871;實測值為437.0877 | 1 H NMR(500 MHz, CDCl3 ) δ 8.14 (s, 1H), 7.53 (s, 1H), 7.37 (t,J = 8.5 Hz, 1H), 6.70 (dd,J = 8.6, 2.6 Hz, 1H), 6.69 - 6.61 (m, 2H), 5.28 (d,J = 1.1 Hz, 2H), 3.81 (s, 3H), 3.34 (q,J = 7.2 Hz, 2H), 3.06 (s, 3H), 2.52 (s, 3H), 1.24 (t,J = 7.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 115.54。 | ||
308 | 對於C19 H20 BrClFN2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為441.0375;實測值為441.0381 | 1 H NMR(500 MHz, CDCl3 ) δ 8.18 (s, 1H), 7.54 (s, 1H), 7.48 (dd,J = 8.6, 6.0 Hz, 1H), 7.17 (dd,J = 8.5, 2.6 Hz, 1H), 7.01 (td,J = 8.3, 2.6 Hz, 1H), 6.70 (s, 1H), 5.36 (s, 2H), 3.35 (q,J = 7.2 Hz, 2H), 3.07 (s, 3H), 2.53 (s, 3H), 1.25 (t,J = 7.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 111.59。 | ||
309 | 對於C20 H23 BrFN2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為421.0921;實測值為421.0927 | 1 H NMR(500 MHz, CDCl3 ) δ 8.09 (s, 1H), 7.53 (s, 1H), 7.25 - 7.20 (m, 1H), 7.02 (d,J = 7.6 Hz, 1H), 6.95 (t,J = 8.9 Hz, 1H), 6.68 (s, 1H), 5.38 (d,J = 1.6 Hz, 2H), 3.34 (q,J = 7.2 Hz, 2H), 3.06 (s, 3H), 2.52 (s, 3H), 2.44 (s, 3H), 1.24 (t,J = 7.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 117.39。 | ||
310 | 對於C19 H21 BrFN2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為407.0765;實測值為407.077 | 1 H NMR(500 MHz, CDCl3 ) δ 8.16 (s, 1H), 7.54 (s, 1H), 7.46 - 7.39 (m, 2H), 7.07 (t,J = 8.7 Hz, 2H), 6.69 (s, 1H), 5.26 (s, 2H), 3.34 (q,J = 7.2 Hz, 2H), 3.07 (s, 3H), 2.53 (s, 3H), 1.25 (t,J = 7.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 113.86。 | ||
311 | (薄膜)2964, 1710, 1628, 1573, 1369, 1228, 1080 | ESIMSm/z 417 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 8.18 (s, 1H), 7.53 (s, 1H), 7.36 (d,J = 7.8 Hz, 2H), 7.22 (d,J = 7.8 Hz, 2H), 6.68 (s, 1H), 5.27 (s, 2H), 3.34 (q,J = 7.0 Hz, 2H), 3.06 (s, 3H), 2.66 (q,J = 7.6 Hz, 2H), 2.54 (s, 3H), 1.25 (t,J = 7.4 Hz, 6H)。 | |
312 | (薄膜)2929, 1711, 1627, 1571, 1226, 1078 | 對於C19 H21 BrClN2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為423.0469;實測值為423.0477 | 1 H NMR(500 MHz, CDCl3 ) δ 8.17 (s, 1H), 7.54 (s, 1H), 7.40 - 7.33 (m, 4H), 6.69 (s, 1H), 5.26 (s, 2H), 3.34 (q,J = 7.2 Hz, 2H), 3.07 (s, 3H), 2.53 (s, 3H), 1.25 (t,J = 7.2 Hz, 3H)。 | |
313 | (薄膜)2928, 1712, 1627, 1571, 1226, 1081, 751 | 對於C19 H21 BrClN2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為423.0469;實測值為423.0477 | 1 H NMR(500 MHz, CDCl3 ) δ 8.21 (s, 1H), 7.54 (s, 1H), 7.51 - 7.47 (m, 1H), 7.44 - 7.39 (m, 1H), 7.31 - 7.27 (m, 2H), 6.70 (s, 1H), 5.41 (s, 2H), 3.35 (q,J = 7.2 Hz, 2H), 3.07 (s, 3H), 2.54 (s, 3H), 1.25 (t,J = 7.2 Hz, 3H)。 | |
314 | 對於C16 H21 BrF3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為409.0733;實測值為409.0739 | 1 H NMR(500 MHz, CDCl3 ) δ 8.13 (s, 1H), 7.55 (s, 1H), 6.70 (s, 1H), 4.32 (t,J = 6.3 Hz, 2H), 3.35 (q,J = 7.2 Hz, 2H), 3.08 (s, 3H), 2.53 (s, 3H), 2.34 - 2.19 (m, 2H), 2.11 - 1.97 (m, 2H), 1.26 (t,J = 7.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 66.35。 | ||
315 | (薄膜)2929, 1708, 1632, 1585, 1372, 1256, 1149, 1110, 1086, 910, 804 | 對於C21 H27 N2 O3 計算的HRMS-ESI (m/z ) [M+H]+ 為355.2016;實測值為355.2021 | 1 H NMR(400 MHz, CDCl3 ) δ 7.63 (s, 1H), 7.49 (s, 1H), 7.34 (d,J = 8.0 Hz, 2H), 7.19 (d,J = 7.8 Hz, 2H), 6.63 (s, 1H), 5.29 (s, 2H), 3.84 (s, 3H), 3.64 - 3.25 (m, 2H), 3.11 - 2.97 (m, 3H), 2.52 (s, 3H), 2.36 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 | |
316 | (薄膜)2931, 1711, 1634, 1586, 1330, 1258, 1202, 1111, 1087, 795 | 對於C21 H24 F3 N2 O3 計算的HRMS-ESI (m/z ) [M+H]+ 為409.1734;實測值為409.1738 | 1 H NMR(400 MHz, CDCl3 ) δ 7.72 (s, 1H), 7.66 - 7.56 (m, 3H), 7.54 - 7.47 (m, 2H), 6.65 (s, 1H), 5.37 (s, 2H), 3.85 (s, 3H), 3.61 - 3.26 (m, 2H), 3.09 - 2.96 (m, 3H), 2.53 (s, 3H), 1.23 (t,J = 7.2 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 62.67。 | |
317 | (薄膜)2931, 1711, 1632, 1585, 1374, 1258, 1229, 1148, 1110, 1086 | ESIMSm/z 359 [(M+H)+ ] | 1 H NMR(400 MHz, CDCl3 ) δ 7.63 (s, 1H), 7.54 - 7.43 (m, 2H), 7.36 - 7.29 (m, 1H), 7.21 - 7.05 (m, 2H), 6.64 (s, 1H), 5.40 (s, 2H), 3.84 (s, 3H), 3.62 - 3.27 (m, 2H), 3.10 - 2.97 (m, 3H), 2.51 (s, 3H), 1.23 (t,J = 7.1 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 117.89。 | |
318 | ESIMSm/z 377 [(M+H)+ ] | 1 H NMR(600 MHz, CDCl3 ) δ 7.76 (s, 1H), 7.48 (s, 1H), 7.42 (t,J = 8.0 Hz, 1H), 7.14 (ddd,J = 11.5, 9.9, 2.1 Hz, 2H), 6.57 (s, 1H), 5.32 (d,J = 1.2 Hz, 2H), 3.42 (d,J = 117.8 Hz, 2H), 3.01 (s, 3H), 2.53 (s, 3H), 2.23 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 115.19。 | ||
319 | (薄膜)3397, 2933, 1714, 1592, 1329, 1206, 1124, 1073, 702 | ESIMSm/z 441 [(M+H)+ ] | 1 H NMR(400 MHz, CDCl3 ) δ 8.34 (s, 1H), 7.71 (s, 1H), 7.66 - 7.57 (m, 3H), 7.52 (d,J = 7.3 Hz, 2H), 5.39 (s, 2H), 3.95 - 3.81 (m, 5H), 3.31 (s, 3H), 2.57 (s, 3H), 1.31 (t,J = 7.2 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 62.70。 | |
320 | (薄膜)3349, 3229, 2930, 1717, 1520, 1381, 1329, 1250, 1143, 1033, 760 | 126-130 | ESIMSm/z 375 [(M+H)+ ] | 1 H NMR(400 MHz, CDCl3 ) δ 7.69 (d,J = 8.4 Hz, 1H), 7.46 (td,J = 7.4, 1.8 Hz, 1H), 7.39 - 7.30 (m, 1H), 7.20 - 7.04 (m, 3H), 6.77 (s, 1H), 5.39 (s, 2H), 3.87 (q,J = 7.2 Hz, 2H), 3.21 (s, 3H), 2.51 (s, 3H), 2.21 (s, 3H), 1.29 (t,J = 7.2 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 117.83。 |
321 | (薄膜)3345, 3233.2930, 1715, 1519, 1328, 1252, 1142, 1037, 783 | ESIMSm/z 375 [(M+H)+ ] | 1 H NMR(400 MHz, CDCl3 ) δ 7.71 (d,J = 8.4 Hz, 1H), 7.35 (td,J = 8.0, 5.8 Hz, 1H), 7.20 (dt,J = 7.9, 1.1 Hz, 1H), 7.17 - 7.07 (m, 2H), 7.06 - 6.95 (m, 1H), 6.78 (s, 1H), 5.31 (s, 2H), 3.87 (q,J = 7.1 Hz, 2H), 3.22 (s, 3H), 2.52 (s, 3H), 2.22 (s, 3H), 1.30 (t,J = 7.2 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 112.77。 | |
322 | (薄膜)3346, 3259, 2930, 1716, 1512, 1329, 1143, 1036, 739 | ESIMSm/z 375 [(M+H)+ ] | 1 H NMR(400 MHz, CDCl3 ) δ 7.68 (d,J = 8.4 Hz, 1H), 7.42 (dd,J = 8.6, 5.4 Hz, 2H), 7.12 - 7.03 (m, 3H), 6.76 (s, 1H), 5.29 (s, 2H), 3.87 (q,J = 7.2 Hz, 2H), 3.22 (s, 3H), 2.50 (s, 3H), 2.21 (s, 3H), 1.30 (t,J = 7.3 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 113.70。 | |
323 | ESIMSm/z 435 [(M+H)+ ] | 1 H NMR(400 MHz, CDCl3 ) δ 7.72 (s, 1H), 7.63 (d,J = 7.7 Hz, 1H), 7.59 (d,J = 7.9 Hz, 1H), 7.53 - 7.46 (m, 2H), 6.60 (d,J = 0.8 Hz, 1H), 5.37 (s, 2H), 3.79 (s, 3H), 3.28 (t,J = 6.1 Hz, 2H), 3.05 (s, 3H), 2.50 (s, 3H), 2.19 (t,J = 6.6 Hz, 2H), 1.87 - 1.76 (m, 2H), 1.67 - 1.60 (m, 2H)。 19 F NMR (376 MHz, CDCl3 ) δ - 62.69。 | ||
324 | (薄膜)3405, 2920, 1712, 1629, 1574, 1255, 1129, 1113, 792 | 85-87 | 對於C21 H23 F4 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為411.1690;實測值為411.1700 | 1 H NMR(500 MHz, CDCl3 ) δ 7.69 (d,J = 8.1 Hz, 2H), 7.57 (t,J = 7.3 Hz, 1H), 7.52 - 7.30 (m, 1H), 7.29 - 7.19 (m, 1H), 6.62 (d,J = 8.3 Hz, 1H), 5.40 (s, 2H), 3.41 (d,J = 107.5 Hz, 2H), 3.01 (s, 3H), 2.52 (s, 3H), 2.28 (s, 3H), 1.21 (td,J = 7.2, 1.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 61.26 (d,J = 12.1 Hz), - 119.49 (q,J = 13.6 Hz)。 |
325 | (薄膜)2925, 1709, 1631, 1591, 1547, 1371, 1327, 1245, 1106, 782, 748 | 54-56 | 對於C21 H23 F4 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為411.169;實測值為411.1700 | 1 H NMR(500 MHz, CDCl3 ) δ 7.80 (s, 1H), 7.75 - 7.68 (m, 1H), 7.63 - 7.55 (m, 1H), 7.55 - 7.43 (m, 1H), 7.31 - 7.16 (m, 1H), 6.58 (s, 1H), 5.41 (d,J = 1.4 Hz, 2H), 3.42 (d,J = 98.7 Hz, 2H), 3.01 (s, 3H), 2.55 (s, 3H), 2.24 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 61.26 (d,J = 13.8 Hz), - 119.48 - - 119.60 (m)。 |
326 | ESIMSm/z 356 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.67 (s, 1H), 7.46 (s, 1H), 7.35 (d,J = 7.9 Hz, 2H), 7.17 (d,J = 7.8 Hz, 2H), 6.33 (s, 1H), 5.27 (s, 2H), 3.88 (s, 3H), 3.59 - 3.27 (m, 2H), 3.01 (s, 3H), 2.35 (s, 3H), 2.16 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 13 C NMR (126 MHz, CDCl3 ) δ 165.89, 159.40, 156.40, 151.82, 137.60, 133.78, 133.42, 129.13, 128.24, 123.29, 112.68, 103.35, 65.90, 56.17, 47.88, 32.01, 21.22, 17.03, 14.34。 | ||
327 | ESIMSm/z 410 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.78 (s, 1H), 7.71 (s, 1H), 7.63 (d,J = 7.7 Hz, 1H), 7.57 (d,J = 7.9 Hz, 1H), 7.48 (t,J = 7.7 Hz, 2H), 6.35 (s, 1H), 5.37 (s, 2H), 3.90 (s, 3H), 3.43 (d,J = 98.4 Hz, 2H), 3.03 (s, 3H), 2.19 (s, 3H), 1.23 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 62.57。 | ||
328 | ESIMSm/z 360 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.69 (s, 1H), 7.53 (td,J = 7.5, 1.8 Hz, 1H), 7.42 (d,J = 44.3 Hz, 1H), 7.29 (tdd,J = 7.4, 5.2, 1.8 Hz, 1H), 7.14 (td,J = 7.5, 1.2 Hz, 1H), 7.07 (ddd,J = 9.6, 8.3, 1.1 Hz, 1H), 6.34 (s, 1H), 5.38 (s, 2H), 3.88 (s, 3H), 3.61 - 3.26 (m, 2H), 3.02 (s, 3H), 2.18 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 118.07。 | ||
329 | ESIMSm/z 374 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.60 (s, 1H), 7.45 (s, 1H), 7.21 (td,J = 7.9, 5.7 Hz, 1H), 7.00 (d,J = 7.6 Hz, 1H), 6.93 (t,J = 8.9 Hz, 1H), 6.31 (s, 1H), 5.37 (d,J = 1.6 Hz, 2H), 3.85 (s, 3H), 3.42 (d,J = 96.7 Hz, 2H), 3.01 (s, 3H), 2.45 (s, 3H), 2.14 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 117.43。 | ||
330 | ESIMSm/z 377 [(M+2H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.67 (s, 1H), 7.47 (s, 1H), 7.40 (d,J = 8.3 Hz, 2H), 7.35 - 7.31 (m, 2H), 6.33 (s, 1H), 5.27 (s, 2H), 3.88 (s, 3H), 3.43 (d,J = 98.8 Hz, 2H), 3.02 (s, 3H), 2.18 (s, 3H), 1.23 (t,J = 7.2 Hz, 3H)。 13 C NMR (126 MHz, CDCl3 ) δ 165.74, 159.46, 156.63, 151.83, 135.37, 133.66, 133.41, 129.44, 128.62, 123.40, 112.24, 103.28, 65.12, 56.13, 47.91, 32.01, 31.60, 17.06。 | ||
331 | ESIMSm/z 377 [(M+2H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.73 (s, 1H), 7.59 - 7.55 (m, 1H), 7.48 (s, 1H), 7.39 (dd,J = 7.2, 2.1 Hz, 1H), 7.30 - 7.22 (m, 2H), 6.34 (s, 1H), 5.42 (s, 2H), 3.89 (s, 3H), 3.61 - 3.27 (m, 2H), 3.02 (s, 3H), 2.19 (s, 3H), 1.23 (t,J = 7.2 Hz, 3H)。 | ||
332 | 141-144 | ESIMSm/z 375 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.82 (s, 1H), 7.46 (td,J = 7.5, 1.8 Hz, 1H), 7.34 (tdd,J = 7.5, 5.3, 1.8 Hz, 1H), 7.16 (td,J = 7.5, 1.2 Hz, 1H), 7.13 - 7.07 (m, 2H), 6.78 (s, 1H), 5.38 (s, 2H), 3.86 (q,J = 7.2 Hz, 2H), 3.21 (s, 3H), 2.54 (s, 3H), 2.24 (s, 3H), 1.29 (t,J = 7.1 Hz, 3H)。 13 C NMR (126 MHz, CDCl3 ) δ 181.71, 166.75, 161.06 (d,J = 248.4 Hz), 141.73, 139.15, 133.38, 130.70 (d,J = 3.7 Hz), 130.27 - 130.16 (m, 2C), 128.77, 126.54, 124.18 (d,J = 3.7 Hz), 123.27 (d,J = 14.5 Hz), 115.51 (d,J = 21.2 Hz), 60.40, 48.92, 38.36, 21.58, 17.57, 12.07。 19 F NMR (471 MHz, CDCl3 ) δ - 117.82。 | |
333 | 130-132 | ESIMSm/z 429 [(M+H)+ ] | 1 H NMR(500 MHz, DMSO-d 6 ) δ 8.94 (s, 1H), 7.86 (s, 1H), 7.82 (d,J = 7.7 Hz, 1H), 7.73 (d,J = 7.8 Hz, 1H), 7.69 - 7.63 (m, 2H), 7.25 (d,J = 7.5 Hz, 1H), 5.42 (s, 2H), 3.81 (q,J = 7.0 Hz, 2H), 3.22 (s, 3H), 2.48 (s, 3H), 1.15 (q,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, DMSO-d 6 ) δ - 61.06, -122.55。 | |
334 | ESIMSm/z 359 ([M+H]+ )。 | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.90 - 7.75 (m, 1H), 7.65 (d,J = 0.8 Hz, 1H), 7.31 - 7.20 (m, 3H), 7.16 (d,J = 7.6 Hz, 1H), 7.08 - 6.98 (m, 1H), 5.25 (s, 2H), 3.51 - 3.38 (m, 2H), 3.05 - 2.95 (m, 3H), 2.32 (s, 3H), 2.17 (s, 3H), 1.17 - 1.11 (m, 3H)。 | ||
335 | 82-85 | ESIMSm/z 429 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.91 - 7.79 (m, 1H), 7.68 (d,J = 0.8 Hz, 1H), 7.64 - 7.57 (m, 2H), 7.41 (d,J = 8.0 Hz, 2H), 7.06 - 6.95 (m, 1H), 5.33 (s, 2H), 3.58 - 3.35 (m, 2H), 3.08 - 2.85 (m, 3H), 2.18 (s, 3H), 1.17 - 1.11 (m, 3H)。 19 F NMR (376 MHz, DMSO-d 6 ) δ - 56.78。 | |
336 | 54-58 | ESIMSm/z 379 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.92 - 7.87 (m, 1H), 7.66 (s, 1H), 7.04 - 6.90 (m, 4H), 7.05 - 6.95 (m, 1H), 5.28 (s, 2H), 3.55 - 3.35 (m, 2H), 3.10 - 2.88 (m, 3H), 2.17 (s, 3H), 1.21 - 1.08 (m, 3H)。 | |
337 | ESIMSm/z 365 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.98 - 7.74 (m, 1H), 7.65 (d,J = 0.4 Hz, 1H), 7.08 - 6.92 (m, 1H), 4.27 (t,J =6.4 Hz, 2H), 3.55 - 3.35 (m, 2H), 3.12 - 2.90 (m, 3H), 2.48 - 2.32 (m, 2H), 2.40 (s, 3H), 2.01 - 1.82 (m, 2H), 1.22 - 1.08 (m, 3H)。 19 F NMR (376 MHz, DMSO-d 6 ) δ - 64.83。 | ||
338 | 69-72 | ESIMSm/z 377 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.94 - 7.73 (m, 1H), 7.59 (s, 1H), 7.48 - 7.32 (m, 1H), 7.17 - 6.92 (m, 3H), 5.28 (s, 2H), 3.52 - 3.33 (m, 2H), 3.10 - 2.90 (m, 3H), 2.33 (s, 3H), 2.16 (s, 3H), 1.25 - 1.05 (m, 3H)。 19 F NMR (376 MHz, DMSO-d 6 ) δ - 118.97。 | |
339 | 84-88 | ESIMSm/z 377 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.96 - 7.75 (m, 1H), 7.61 (d,J = 0.4 Hz, 1H), 7.50 - 7.40 (m, 1H), 7.11 (dd,J = 10.0, 2.4 Hz, 1H), 7.08 - 6.95 (m, 2H), 5.28 (s, 2H), 3.50 - 3.35 (m, 2H), 3.05 - 2.95 (m, 3H), 2.38 (s, 3H), 2.16 (s, 3H), 1.20 - 1.05 (m, 3H)。 19 F NMR (376 MHz, DMSO-d 6 ) δ - 114.39。 | |
340 | 75-79 | ESIMSm/z 414 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 8.89 (d,J = 0.8 Hz, 1H), 8.19 (dd,J = 8.0, 1.6 Hz, 1H), 7.97 (d,J = 8.0 Hz, 1H), 7.94 - 7.78 (m, 1H), 7.72 (d,J = 0.4 Hz, 1H), 7.10 - 6.99 (m, 1H), 5.45 (s, 2H), 3.50 - 3.35 (m, 2H), 3.06 - 2.90 (m, 3H), 2.18 (s, 3H), 1.21 - 1.08 (m, 3H)。 19 F NMR (376 MHz, DMSO-d 6 ) δ - 66.38。 | |
341 | 75-79 | ESIMSm/z 360 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 8.55 (d,J = 1.6 Hz, 1H), 7.95 - 7.75 (m, 2H), 7.64 (s, 1H), 7.29 (d,J = 8.0 Hz, 1H), 7.03 - 6.95 (m, 1H), 5.28 (s, 2H), 3.50 - 3.37 (m, 2H), 3.07 - 2.91 (m, 3H), 2.47 (s, 3H), 2.17 (s, 3H), 1.22 - 1.07 (m, 3H)。 | |
342 | 94-97 | ESIMSm/z 414 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 8.79 (d,J = 4.8 Hz, 1H), 7.98 (s, 1H), 7.92 - 7.75 (m, 3H), 7.10 - 6.95 (m, 1H), 5.47 (s, 2H), 3.51 - 3.38 (m, 2H), 3.08 - 2.95 (m, 3H), 2.20 (s, 3H), 1.25 - 1.10 (m, 3H)。 19 F NMR (376 MHz, DMSO-d 6 ) δ - 66.58。 | |
343 | ESIMSm/z 359 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.93 - 7.73 (m, 1H), 7.51 (s, 1H), 7.37 - 7.28 (m, 4H), 7.28 - 7.18 (m, 1H), 7.05 - 6.92 (m, 1H), 4.42 (t,J = 6.8 Hz, 2H), 3.55 - 3.35 (m, 2H), 3.10 - 2.95 (m, 5H), 2.15 (s, 3H), 1.25 - 1.05 (m, 3H)。 | ||
344 | 52-56 | ESIMSm/z 427 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.93 - 7.75 (m, 1H), 7.68 (d,J = 8.0 Hz, 2H), 7.56 (d,J = 8.0 Hz, 2H), 7.46 (s, 1H), 7.00 - 6.92 (m, 1H), 4.48 (t,J = 6.8 Hz, 2H), 3.48 - 3.36 (m, 2H), 3.13 (t,J = 6.8 Hz, 2H), 3.05 - 2.96 (m, 3H), 2.13 (s, 3H), 1.21 - 1.07 (m, 3H)。 19 F NMR (376 MHz, DMSO-d 6 ) δ - 60.78。 | |
345 | ESIMSm/z 355 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.93 - 7.74 (m, 1H), 7.60 (s, 1H), 7.04 - 6。92 (m, 1H), 4.40 - 4.25 (m, 2H), 3.51 - 3.36 (m, 2H), 3.10 - 2.88 (m, 3H), 2.17 (s, 3H), 1.25 - 1.02 (m, 5H), 0.05 (m, 9H)。 | ||
346 | ESIMSm/z 351 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.96 - 7.73 (m, 1H), 7.60 (s, 1H), 7.07 - 6.90 (m, 1H), 4.04 (d,J = 5.6 Hz, 2H), 3.55 - 3.38 (m, 2H), 3.08 - 2.90 (m, 3H), 2.18 (s, 3H), 1.85 - 1.53 (m, 6H), 1.40 - 0.98 (m, 8H)。 | ||
347 | 46-50 | ESIMSm/z 337 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ7.92 - 7.87 (m, 1H), 7.60 (d,J = 0.8 Hz, 1H), 7.04 - 6.90 (m, 1H), 4.11 (d,J = 7.2 Hz, 2H), 3.55 - 3.35 (m, 2H), 3.09 - 2.88 (m, 3H), 2.32 - 2.22 (m, 1H), 2.17 (s, 3H), 1.83 - 1.68 (m, 2H), 1.68 - 1.46 (m, 4H),1.40 - 1.25 (m, 2H), 1.21 - 1.08 (m, 3H)。 | |
348 | ESIMSm/z 369 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.92 - 7.75 (m, 1H), 7.60 (s, 1H), 7.03 - 6.93 (m, 1H), 4.16 (t,J = 6.8 Hz, 2H), 3.42 - 3.35 (m, 2H), 3.10 - 2.90 (m, 3H), 2.17 (s, 3H), 1.75 - 1.62 (m, 2H), 1.21 - 1.05 (m, 3H), 0.61 - 0.50 (m, 2H), 0.00 (s, 9H)。 | ||
349 | 49-53 | ESIMSm/z 360 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 8.41 (s, 1H), 7.94 - 7.78 (m, 1H), 7.70 (s, 1H), 7.68 - 7.60 (m, 1H), 7.40 (d,J = 8.0 Hz, 1H), 7.10 - 6.96 (m, 1H), 5.31 (s, 2H), 3.55 - 3.35 (m, 2H), 3.04 - 2.96 (m, 3H), 2.30 (s, 3H), 2.18 (s, 3H), 1.17 - 1.11 (m, 3H)。 | |
350 | ESIMSm/z 431 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.98 - 7.73 (m, 3H), 7.71 - 7.61 (m, 2H), 7.07 - 6.97 (m, 1H), 5.42 (s, 2H), 3.48 - 3.35 (m, 2H), 3.11 - 2.80 (m, 3H), 2.18 (s, 3H), 1.20 - 1.05 (m, 3H)。 19 F NMR (376 MHz, DMSO-d 6 ) δ - 61.16, - 115.13。 | ||
351 | 84-88 | ESIMSm/z 410 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.93 - 7.76 (m, 1H),7.65 (s, 1H), 7.48 (d,J = 8.4 Hz, 2H), 7.40 - 7.32 (m, 2H), 7.05 - 6.95 (m, 1H), 5.28 (s, 2H), 3.50 - 3.35 (m, 2H), 3.08 - 2.92 (m, 3H), 2.17 (s, 3H), 1.78 - 1.74 (m, 2H), 1.54 - 1.49 (m, 2H), 1.21 - 1.08 (m, 3H)。 | |
352 | ESIMSm/z 373 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.94 - 7.72 (m, 1H), 7.67 (s, 1H), 7.46 (d,J = 6.8 Hz, 1H), 7.80 - 7.25 (m, 3H), 7.06 - 6.92 (m, 1H), 6.13 (q,J = 6.8 Hz, 1H), 3.50 - 3.32 (m, 2H), 3.03 - 2.95 (m, 3H), 2.38 (s, 3H), 2.19 (s, 3H), 1.56 (d,J = 6.4 Hz, 3H), 1.17 - 1.11 (m, 3H)。 | ||
353 | ESIMSm/z 373 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.91 - 7.76 (m, 1H), 7.51 (s, 1H), 7.19 (d,J = 8.0 Hz, 2H), 7.12 (d,J = 8.0 Hz, 2H), 7.02 - 6.92 (m, 1H), 4.38 (t,J = 6.8 Hz, 2H), 3.49 - 3.38 (m, 2H), 3.12 - 2.90 (m, 5H), 2.27 (s, 3H), 2.15 (s, 3H), 1.23 - 1.08 (m, 3H)。 | ||
354 | 45-49 | ESIMSm/z 427 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.95 - 7.53 (m, 5H), 7.48 (s, 1H), 7.00 - 6.91 (m, 1H), 4.47 (t,J = 6.4 Hz, 2H), 3.51 - 3.36 (m, 2H), 3.13 (t,J = 6.4 Hz, 2H), 3.08 - 2.92 (m, 3H), 2.13 (s, 3H), 1.22 - 1.05 (m, 3H)。 19 F NMR (376 MHz, DMSO-d 6 ) δ - 60.99。 | |
355 | ESIMSm/z 309 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.94 - 7.75 (m, 1H), 7.61 (d,J = 0.8 Hz, 1H), 7.05 - 6.93 (m, 1H), 4.06 (d,J = 7.2 Hz, 2H), 3.52 - 3.36 (m, 2H), 3.08 - 2.92 (m, 3H), 2.18 (s, 3H), 1.28 - 1.08 (m, 4H),0.63 - 0.52 (m, 2H), 0.38 - 0.28 (m, 2H)。 | ||
356 | ESIMSm/z 345 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.95 - 7.75 (m, 1H), 7.63 (d,J = 0.8 Hz, 1H), 7.05 - 6.94 (m, 1H), 4.45 - 4.34 (m, 1H), 4.22 - 4.12 (m, 1H), 3.50 - 3.36 (m, 2H), 3.08 - 2.92 (m, 3H), 2.28 - 2.20 (m, 1H), 2.19 (s, 3H), 1.82 - 1.56 (m, 1H), 1.60 - 1.46 (m, 1H), 1.22 - 1.08 (m, 3H)。 19 F NMR (376 MHz, DMSO-d 6 ) δ - 127.82 (dt,J = 154.5, 11.3 Hz, 1F), - 141.79 (ddd,J = 158.2, 15.1, 3.8 Hz, 1F)。 | ||
357 | 52-56 | ESIMSm/z 351 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.95 - 7.77 (m, 1H), 7.64 (d,J = 0.8 Hz, 1H), 7.08 - 6.92 (m, 1H), 4.43 (t,J = 6.0 Hz, 2H), 3.48 - 3.38 (m, 2H), 3.08 - 2.92 (m, 3H), 2.88 - 2.72 (m, 2H), 2.17 (s, 3H), 1.21 - 1.08 (m, 3H)。 19 F NMR (376 MHz, DMSO-d 6 ) δ - 63.33。 | |
358 | (薄膜)2971, 2927, 1709, 1630, 1575, 1368, 1250, 1140, 1064, 777 | 對於C21 H26 FN2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為357.1973;實測值為357.1972 | 1 H NMR(400 MHz, CDCl3 ) δ 7.68 (d,J = 8.3 Hz, 1H), 7.41 (s, 1H), 7.33 - 7.27 (m, 1H), 7.16 (td,J = 7.5, 1.8 Hz, 1H), 7.03 (t,J = 7.6 Hz, 1H), 6.61 (d,J = 8.3 Hz, 1H), 5.36 (s, 2H), 3.61 - 3.23 (m, 2H), 3.01 (s, 3H), 2.52 (s, 3H), 2.30 (d,J = 2.2 Hz, 3H), 2.27 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 122.43。 | |
359 | (薄膜)2973, 2929, 1711, 1630, 1575, 1518, 1249, 1139, 1063, 778 | 對於C20 H22 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為379.1628;實測值為379.1626 | 1 H NMR(400 MHz, CDCl3 ) δ 7.67 (d,J = 8.3 Hz, 1H), 7.43 (s, 1H), 7.32 (ddd,J = 10.4, 8.7, 6.6 Hz, 1H), 6.95 (ddd,J = 10.1, 9.1, 6.4 Hz, 1H), 6.62 (d,J = 8.4 Hz, 1H), 5.29 (s, 2H), 3.60 - 3.22 (m, 2H), 3.02 (s, 3H), 2.51 (s, 3H), 2.28 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 119.29 (dd,J = 15.6, 4.0 Hz), - 133.56 (dd,J = 21.1, 4.2 Hz), - 142.51 (dd,J = 21.3, 15.6 Hz)。 | |
360 | (薄膜)2932.1707.1627、1574、1511、1248、1140、1063、833 | 對於C21 H26 FN2 O3 計算的HRMS-ESI (m/z ) [M+H]+ 為373.1922;實測值為373.1920 | 1 H NMR(400 MHz, CDCl3 ) δ 7.63 (d,J = 8.3 Hz, 1H), 7.41 - 7.33 (m, 2H), 6.72 - 6.62 (m, 2H), 6.59 (d,J = 8.3 Hz, 1H), 5.29 (d,J = 1.2 Hz, 2H), 3.80 (s, 3H), 3.59 - 3.20 (m, 2H), 3.01 (s, 3H), 2.50 (s, 3H), 2.26 (s, 3H), 1.21 (t,J = 7.2 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 115.64。 | |
361 | (薄膜)2931, 1709, 1629, 1575, 1369, 1247, 1139, 1064, 778 | 對於C21 H25 F2 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為375.1879;實測值為375.1875 | 1 H NMR(400 MHz, CDCl3 ) δ 7.65 (d,J = 8.3 Hz, 1H), 7.41 (s, 1H), 7.31 - 7.23 (m, 1H), 6.84 (td,J = 8.6, 1.6 Hz, 1H), 6.60 (d,J = 8.4 Hz, 1H), 5.31 (s, 2H), 3.59 - 3.20 (m, 2H), 3.01 (s, 3H), 2.50 (s, 3H), 2.27 (s, 3H), 2.21 (t,J = 1.9 Hz, 3H), 1.21 (t,J = 7.2 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 114.41, - 118.32。 | |
362 | 163-165 | ESIMSm/z 393 [(M+H)+ ] | 1 H NMR(500 MHz, DMSO-d 6 ) δ 8.83 (s, 1H), 7.60 (s, 1H), 7.53 (tt,J = 8.5, 6.7 Hz, 1H), 7.19 (t,J = 8.0 Hz, 2H), 7.01 (s, 1H), 5.38 (s, 2H), 3.79 (q,J = 7.0 Hz, 2H), 3.20 (s, 3H), 2.42 (s, 3H), 2.14 (s, 3H), 1.14 (t,J = 7.0 Hz, 3H)。 19 F NMR (471 MHz, DMSO-d 6 ) δ - 114.58。 | |
363 | 126-128 | ESIMSm/z 409 [(M+H)+ ] | 1 H NMR(500 MHz, DMSO-d 6 ) δ 8.83 (s, 1H), 7.67 (s, 1H), 7.61 (t,J = 8.2 Hz, 1H), 7.52 (dd,J = 10.0, 2.1 Hz, 1H), 7.36 (dd,J = 8.3, 2.1 Hz, 1H), 7.02 (s, 1H), 5.35 (s, 2H), 3.80 (q,J = 7.0 Hz, 2H), 3.20 (s, 3H), 2.44 (s, 3H), 2.15 (s, 3H), 1.14 (t,J = 7.0 Hz, 3H)。 19 F NMR (471 MHz, DMSO-d 6 ) δ - 114.90。 | |
364 | 132-134 | ESIMSm/z 393 [(M+H)+ ] | 1 H NMR(500 MHz, DMSO-d 6 ) δ 8.84 (s, 1H), 7.70 (s, 1H), 7.44 (ddd,J = 8.9, 5.7, 3.2 Hz, 1H), 7.40 - 7.25 (m, 2H), 7.03 (s, 1H), 5.34 (s, 2H), 3.80 (q,J = 7.0 Hz, 2H), 3.21 (s, 3H), 2.45 (s, 3H), 2.16 (s, 3H), 1.14 (t,J = 7.0 Hz, 3H)。 19 F NMR (471 MHz, DMSO-d 6 ) δ - 118.41, - 123.42。 | |
365 | 137-139 | ESIMSm/z 409 [(M+H)+ ] | 1 H NMR(500 MHz, DMSO-d 6 ) δ 8.83 (s, 1H), 7.61 (s, 1H), 7.52 (td,J = 8.2, 6.1 Hz, 1H), 7.46 - 7.41 (m, 1H), 7.34 (ddd,J = 9.5, 8.3, 1.2 Hz, 1H), 7.01 (s, 1H), 5.43 (d,J = 1.7 Hz, 2H), 3.79 (q,J = 7.0 Hz, 2H), 3.20 (s, 3H), 2.43 (s, 3H), 2.13 (s, 3H), 1.14 (t,J = 7.0 Hz, 3H)。 19 F NMR (471 MHz, DMSO-d 6 ) δ - 112.97。 | |
366 | 167-169 | ESIMSm/z 443 [(M+H)+ ] | 1 H NMR(500 MHz, DMSO-d 6 ) δ 8.82 (s, 1H), 7.76 - 7.67 (m, 3H), 7.57 (s, 1H), 7.01 (s, 1H), 5.45 (s, 2H), 3.79 (q,J = 7.0 Hz, 2H), 3.20 (s, 3H), 2.41 (s, 3H), 2.12 (s, 3H), 1.13 (t,J = 7.0 Hz, 3H)。 19 F NMR (471 MHz, DMSO-d 6 ) δ - 57.62, - 113.62。 | |
367 | 127-129 | ESIMSm/z 393 [(M+H)+ ] | 1 H NMR(500 MHz, DMSO-d 6 ) δ 8.84 (s, 1H), 7.69 (s, 1H), 7.47 (dtd,J = 9.8, 8.1, 1.6 Hz, 1H), 7.42 - 7.36 (m, 1H), 7.30 - 7.23 (m, 1H), 7.03 (s, 1H), 5.41 (s, 2H), 3.80 (q,J = 7.0 Hz, 2H), 3.21 (s, 3H), 2.45 (s, 3H), 2.16 (s, 3H), 1.14 (t,J = 7.0 Hz, 3H)。 19 F NMR (471 MHz, DMSO-d 6 ) δ - 57.62, - 113.62。 | |
368 | 116-118 | ESIMSm/z 393 [(M+H)+ ] | 1 H NMR(500 MHz, DMSO-d 6 ) δ 8.83 (s, 1H), 7.65 (d,J = 7.5 Hz, 2H), 7.33 (ddd,J = 10.4, 9.4, 2.6 Hz, 1H), 7.18 - 7.11 (m, 1H), 7.02 (s, 1H), 5.33 (s, 2H), 3.80 (q,J = 7.0 Hz, 2H), 3.20 (s, 3H), 2.44 (s, 3H), 2.15 (s, 3H), 1.14 (t,J = 7.0 Hz, 3H)。 19 F NMR (471 MHz, DMSO-d 6 ) δ - 109.39, - 113.46。 | |
369 | ESIMSm/z 361 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.72 (s, 1H), 7.46 (s, 1H), 7.32 (tt,J = 8.6, 6.4 Hz, 1H), 6.97 - 6.90 (m, 2H), 6.55 (s, 1H), 5.38 (d,J = 1.6 Hz, 2H), 3.41 (d,J = 90.3 Hz, 2H), 3.00 (s, 3H), 2.52 (s, 3H), 2.21 (s, 3H), 1.21 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 114.13。 | ||
370 | ESIMSm/z 361 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.78 (s, 1H), 7.48 (s, 1H), 7.26 - 7.21 (m, 1H), 7.19 - 7.10 (m, 1H), 7.08 (dtd,J = 9.6, 4.9, 2.5 Hz, 1H), 6.57 (s, 1H), 5.38 (d,J = 1.4 Hz, 2H), 3.42 (d,J = 93.9 Hz, 2H), 3.01 (s, 3H), 2.54 (s, 3H), 2.24 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 138.34 (d,J = 16.8 Hz), - 142.81 (dt,J = 20.8, 6.8 Hz)。 | ||
371 | ESIMSm/z 361 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.76 (s, 1H), 7.47 (td,J = 8.4, 6.4 Hz, 2H), 6.92 - 6.81 (m, 2H), 6.57 (s, 1H), 5.32 (s, 2H), 3.42 (d,J = 92.4 Hz, 2H), 3.01 (s, 3H), 2.53 (s, 3H), 2.23 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 109.87 (t,J = 7.9 Hz), - 113.49 (q,J = 8.7 Hz)。 | ||
372 | 對於C20 H23 F2 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為361.1722;實測值為361.1720 | 1 H NMR(400 MHz, CDCl3 ) δ 7.68 (d,J = 8.4 Hz, 1H), 7.42 (s, 1H), 7.25 - 7.22 (m, 1H), 7.19 - 7.03 (m, 2H), 6.61 (d,J = 8.3 Hz, 1H), 5.38 (d,J = 1.5 Hz, 2H), 3.61 - 3.23 (m, 2H), 3.02 (s, 3H), 2.51 (s, 3H), 2.27 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 138.34 (d,J = 20.8 Hz), -142.79 (d,J = 20.1 Hz)。 | ||
373 | 對於C20 H23 F2 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為361.1722;實測值為361.1720 | 1 H NMR(400 MHz, CDCl3 ) δ 7.65 (d,J = 8.4 Hz, 1H), 7.51 - 7.37 (m, 2H), 6.91 - 6.80 (m, 2H), 6.60 (d,J = 8.4 Hz, 1H), 5.32 (s, 2H), 3.62 - 3.21 (m, 2H), 3.02 (s, 3H), 2.50 (s, 3H), 2.27 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 109.82 (d,J = 8.2 Hz), - 113.47 (d,J = 8.2 Hz)。 | ||
374 | 對於C20 H23 F2 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為361.1722;實測值為361.1720 | 1 H NMR(400 MHz, CDCl3 ) δ 7.69 (d,J = 8.3 Hz, 1H), 7.43 (s, 1H), 7.19 (ddd,J = 8.6, 5.6, 3.1 Hz, 1H), 7.09 - 6.92 (m, 2H), 6.62 (d,J = 8.4 Hz, 1H), 5.34 (s, 2H), 3.69 - 3.24 (m, 2H), 3.02 (s, 3H), 2.52 (s, 3H), 2.28 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 118.77 (d,J = 18.0 Hz), - 124.04 (d,J = 18.0 Hz)。 | ||
375 | 對於C20 H23 F2 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為361.1722;實測值為361.1720 | 1 H NMR(400 MHz, CDCl3 ) δ 7.61 (d,J = 8.4 Hz, 1H), 7.47 - 7.27 (m, 2H), 6.93 (dd,J = 8.4, 7.3 Hz, 2H), 6.58 (d,J = 8.3 Hz, 1H), 5.39 (d,J = 1.3 Hz, 2H), 3.64 - 3.15 (m, 2H), 3.01 (s, 3H), 2.50 (s, 3H), 2.26 (s, 3H), 1.21 (t,J = 7.1 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 114.18。 | ||
376 | ESIMSm/z 378 [(M+H)+ ] | 1 H NMR(400 MHz, CDCl3 ) δ 7.62 (d,J = 8.3 Hz, 1H), 7.39 (s, 1H), 7.33 - 7.18 (m, 2H), 7.04 (ddd,J = 9.3, 7.9, 1.5 Hz, 1H), 6.58 (d,J = 8.3 Hz, 1H), 5.45 (d,J = 1.9 Hz, 2H), 3.67 - 3.20 (m, 2H), 3.01 (s, 3H), 2.51 (s, 3H), 2.26 (s, 3H), 1.21 (t,J = 7.2 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 112.76。 | ||
377 | ESIMSm/z 411 [(M+H)+ ] | 1 H NMR(400 MHz, CDCl3 ) δ 7.57 (d,J = 8.3 Hz, 1H), 7.56 - 7.44 (m, 2H), 7.43 - 7.30 (m, 2H), 6.56 (d,J = 8.3 Hz, 1H), 5.47 (s, 2H), 3.57 - 3.21 (m, 2H), 3.00 (s, 3H), 2.50 (s, 3H), 2.26 (s, 3H), 1.20 (t,J = 7.1 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 58.78, - 113.20。 | ||
378 | ESIMSm/z 361 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.79 (s, 1H), 7.48 (s, 1H), 7.19 (ddd,J = 8.7, 5.7, 3.1 Hz, 1H), 7.04 (td,J = 9.0, 4.4 Hz, 1H), 6.99 (dq,J = 8.7, 4.1 Hz, 1H), 6.58 (s, 1H), 5.34 (s, 2H), 3.42 (d,J = 92.1 Hz, 2H), 3.02 (s, 3H), 2.55 (s, 3H), 2.24 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 118.62 - - 118.88 (m), - 123.84 - - 124.22 (m)。 | ||
379 | ESIMSm/z 377 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.72 (s, 1H), 7.46 (s, 1H), 7.29 (td,J = 8.1, 5.7 Hz, 2H), 7.05 (td,J = 8.6, 8.0, 1.3 Hz, 1H), 6.55 (s, 1H), 5.45 (d,J = 1.8 Hz, 2H), 3.41 (d,J = 90.2 Hz, 2H), 3.00 (s, 3H), 2.53 (s, 3H), 2.21 (s, 3H), 1.21 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 112.71。 | ||
380 | ESIMSm/z 411 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.68 (s, 1H), 7.54 (d,J = 7.9 Hz, 1H), 7.49 (td,J = 8.1, 5.2 Hz, 2H), 7.34 (t,J = 8.7 Hz, 1H), 6.55 (s, 1H), 5.46 (s, 2H), 3.41 (d,J = 89.6 Hz, 2H), 3.00 (s, 3H), 2.51 (s, 3H), 2.19 (s, 3H), 1.21 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 58.78, -113.15 (d,J = 7.2 Hz)。 | ||
381 | ESIMSm/z 379 [(M+H)+ ] | 1 H NMR(400 MHz, CDCl3 ) δ 7.77 (s, 1H), 7.44 (d,J = 27.1 Hz, 1H), 7.32 (ddd,J = 10.3, 8.6, 6.6 Hz, 1H), 6.96 (td,J = 9.6, 6.5 Hz, 1H), 6.58 (s, 1H), 5.29 (s, 2H), 3.42 (d,J = 69.3 Hz, 2H), 3.02 (s, 3H), 2.54 (s, 3H), 2.24 (s, 3H), 1.23 (q,J = 7.1, 6.2 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 119.31 (dd,J = 15.3, 4.1 Hz), -133.58 (dd,J = 21.3, 4.9 Hz), -142.50 (dd,J = 21.5, 15.9 Hz)。 | ||
382 | ESIMSm/z 357 [(M+H)+ ] | 1 H NMR(400 MHz, CDCl3 ) δ 7.79 (s, 1H), 7.46 (s, 1H), 7.34 - 7.27 (m, 1H), 7.20 - 7.12 (m, 1H), 7.03 (t,J = 7.6 Hz, 1H), 6.57 (s, 1H), 5.36 (d,J = 1.3 Hz, 2H), 3.42 (d,J = 67.9 Hz, 2H), 3.01 (s, 3H), 2.55 (s, 3H), 2.30 (d,J = 2.1 Hz, 3H), 2.23 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 122.47。 | ||
383 | ESIMSm/z 375 [(M+H)+ ] | 1 H NMR(600 MHz, CDCl3 ) δ 7.76 (s, 1H), 7.47 (s, 1H), 7.28 (dd,J = 8.4, 6.3 Hz, 1H), 6.84 (td,J = 8.6, 1.5 Hz, 1H), 6.56 (s, 1H), 5.31 (d,J = 1.2 Hz, 2H), 3.42 (d,J = 115.8 Hz, 2H), 3.01 (s, 3H), 2.54 (s, 3H), 2.22 (dd,J = 4.6, 2.8 Hz, 6H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (564 MHz, CDCl3 ) δ - 114.48, - 118.37。 | ||
384 | ESIMSm/z 369 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.95 - 7.75 (m, 2H), 7.00 - 6.90 (m, 1H), 4.15 (t,J = 6.8 Hz, 2H), 3.55 - 3.35 (m, 2H), 3.10 - 2.90 (m, 3H), 2.47 (s, 3H), 1.80 - 1.62 (m, 2H), 1.25 - 1.10 (m, 3H), 0.65 - 0.50 (m, 2H), 0.00 (s, 9H)。 | ||
385 | ESIMSm/z 359 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.95 - 7.75 (m, 2H), 7.35 - 7.20 (m, 3H), 7.16 (d,J = 7.2 Hz, 1H), 6.97 - 6.92 (m, 1H), 5.23 (s, 2H), 3.51 - 3.38 (m, 2H), 3.05 - 2.90 (m, 3H), 2.47 (s, 3H), 2.32 (s, 3H), 1.20 - 1.10 (m, 3H)。 | ||
386 | ESIMSm/z 429 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.91 - 7.78 (m, 2H), 7.60 (d,J = 8.8 Hz, 2H), 7.41 (d,J = 8.0 Hz, 2H), 7.00 - 6.91 (m, 1H), 5.31 (s, 2H), 3.55 - 3.38 (m, 2H), 3.08 - 2.90 (m, 3H), 2.48 (s, 3H), 1.20 - 1.11 (m, 3H)。 19 F NMR (376 MHz, DMSO-d 6 ) δ - 56.77。 | ||
387 | 59-63 | ESIMSm/z 379 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.93 - 7.75 (m, 2H), 7.54 - 7.42 (m, 4H), 6.97 - 6.93 (m, 1H), 5.27 (s, 2H), 3.52 - 3.33 (m, 2H), 3.10 - 2.93 (m, 3H), 2.47 (s, 3H), 1.24 - 1.10 (m, 3H)。 | |
388 | ESIMSm/z 365 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.95 - 7.75 (m, 2H), 6.96 - 6.92 (m, 1H), 4.25 (t,J = 6.4 Hz, 2H), 3.51 - 3.35 (m, 2H), 3.10 - 2.90 (m, 3H), 2.49 (s, 3H), 2.48 - 2.34 (m, 2H), 2.00 - 1.85 (m, 2H), 1.20 - 1.10 (m, 3H)。 19 F NMR (376 MHz, DMSO-d 6 ) δ - 64.80。 | ||
389 | 67-70 | ESIMSm/z 377 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.92 - 7.72 (m, 2H), 7.42 (dd,J =8.0, 7.6 Hz, 1H), 7.14 - 7.00 (m, 2H), 6.99 - 6.89 (m, 1H), 5.27 (s, 2H), 3.51 - 3.35 (m, 2H), 3.08 - 2.92 (m, 3H), 2.45 (s, 3H), 2.33 (s, 3H), 1.20 - 1.05 (m, 3H)。 19 F NMR (376 MHz, DMSO-d 6 ) δ - 119.13。 | |
390 | 83-87 | ESIMSm/z 377 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.95 - 7.72 (m, 2H), 7.50 - 7.40 (m, 1H), 7.12 (dd,J = 10.0, 2.8 Hz, 1H), 7.10 - 7.00 (m, 1H), 6.98 - 6.89 (m, 1H), 5.26 (s, 2H), 3.50 - 3.33 (m, 2H), 3.10 - 2.90 (m, 3H), 2.46 (s, 3H), 2.37 (s, 3H), 1.22 - 1.10 (m, 3H)。 19 F NMR (376 MHz, DMSO-d 6 ) δ - 114.36。 | |
391 | 93-97 | ESIMSm/z 414 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 8.89 (s, 1H), 8.21 - 8.18 (m, 1H), 7.96 (d,J = 8.0 Hz, 1H), 7.92 - 7.75 (m, 2H), 7.00 - 6.90 (m, 1H), 5.42 (s, 2H), 3.50 - 3.38 (m, 2H), 3.08 - 2.92 (m, 3H), 2.48 (s, 3H), 1.21 - 1.10 (m, 3H)。 19 F NMR (376 MHz, DMSO-d 6 ) δ - 66.38。 | |
392 | 64-68 | ESIMSm/z 360 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 8.54 (d,J = 2.0 Hz, 1H), 7.92 - 7.75 (m, 3H), 7.29 (d,J = 8.0 Hz, 1H), 7.00 - 6.90 (m, 1H), 5.26 (s, 2H), 3.50 - 3.37 (m, 2H), 3.07 - 2.91 (m, 3H), 2.48 (s, 3H), 2.46 (s, 3H), 1.25 - 1.05 (m, 3H)。 | |
393 | ESIMSm/z 360 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 8.41 (d,J = 2.0 Hz, 1H), 7.95 - 7.78 (m, 2H), 7.66 (dd,J = 8.0, 1.6 Hz, 1H), 7.38 (d,J = 8.0 Hz, 1H), 7.00 - 6.90 (m, 1H), 5.29 (s, 2H), 3.50 - 3.35 (m, 2H), 3.10 - 2.90 (m, 3H), 2.48 (s, 3H), 2.30 (s, 3H), 1.20 - 1.10 (m, 3H)。 | ||
394 | 82-86 | ESIMSm/z 414 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 8.79 (d,J = 5.2 Hz, 1H), 7.97 (s, 1H), 7.93 - 7.72 (m, 3H), 7.05 - 6.92 (m, 1H), 5.44 (s, 2H), 3.54 - 3.38 (m, 2H), 3.08 - 2.94 (m, 3H), 2.51 (s, 3H), 1.23 - 1.10 (m, 3H)。 19 F NMR (376 MHz, DMSO-d 6 ) δ - 66.54。 | |
395 | 62-66 | ESIMSm/z 431 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.95 - 7.72 (m, 4H), 7.70 - 7.62 (m, 1H), 7.00 - 6.92 (m, 1H), 5.41 (s, 2H), 3.50 - 3.38 (m, 2H), 3.10 - 2.90 (m, 3H), 2.47 (s, 3H), 1.20 - 1.05 (m, 3H)。 19 F NMR (376 MHz, DMSO-d 6 ) δ - 61.17, - 115.31。 | |
396 | 101-105 | ESIMSm/z 410 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.93 - 7.75 (m, 2H),7.48 (d,J = 8.4 Hz, 2H), 7.36 (dd,J = 6.8, 2.0 Hz, 2H), 7.00 - 6.88 (m, 1H), 5.26 (s, 2H), 3.52 - 3.35 (m, 2H), 3.10 - 2.90 (m, 3H), 2.47 (s, 3H), 1.80 - 1.70 (m, 2H), 1.58 - 1.48 (m, 2H), 1.20 - 1.08 (m, 3H)。 | |
397 | ESIMSm/z 373 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 8.03 (s, 1H), 7.60 - 7.40 (m, 2H), 7.25 - 7.12 (m, 3H), 6.75 - 6.65 (m, 1H), 6.26 (q,J = 6.8 Hz, 1H), 3.65 - 3.32 (m, 2H), 3.10 - 2.98 (m, 3H), 2.53 (s, 3H), 2.43 (s, 3H), 1.61 (d,J = 6.8 Hz, 3H), 1.25 (t, J = 7.2 Hz, 3H)。 | ||
398 | 72-76 | ESIMSm/z 359 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.90 - 7.70 (m, 2H), 7.35 - 7.28 (m, 4H), 7.25 - 7.20 (m, 1H), 6.95 - 6.85 (m, 1H), 4.42 (t,J = 6.8 Hz, 2H), 3.55 - 3.35 (m, 2H), 3.02 (t,J = 6.4 Hz, 2H), 2.96 (s, 3H), 2.40 (s, 3H), 1.22 - 1.06 (m, 3H)。 | |
399 | 71-74 | ESIMSm/z 373 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.90 - 7.68 (m, 2H), 7.18 (d,J = 8.0 Hz, 2H), 7.12 (d,J = 7.6 Hz, 2H), 6.96 - 6.86 (m, 1H), 4.38 (t,J = 6.8 Hz, 2H), 3.56 - 3.35 (m, 2H), 3.10 - 2.86 (m, 5H), 2.41 (s, 3H), 2.27 (s, 3H), 1.22 - 1.05 (m, 3H)。 | |
400 | 120-124 | ESIMSm/z 427 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.92 - 7.74 (m, 1H), 7.70 - 7.66 (m, 3H), 7.55 (d,J = 8.0 Hz, 2H), 6.94 - 6.86 (m, 1H), 4.47 (t,J = 6.8 Hz, 2H), 3.52 - 3.35 (m, 2H), 3.13 (t,J = 6.6 Hz, 2H), 3.06 - 2.94 (m, 3H), 2.37 (s, 3H), 1.24 - 1.07 (m, 3H)。 19 F NMR (376 MHz, DMSO-d 6 ) δ - 60.79。 | |
401 | 93-97 | ESIMSm/z 426 ([M]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.92 - 7.74 (m, 1H), 7.72 - 7.52 (m, 5H),6.94 - 6.86 (m, 1H), 4.46 (t,J = 6.4 Hz, 2H), 3.50 - 3.35 (m, 2H), 3.14 (t,J = 6.4 Hz, 2H), 3.08 - 2.88 (m, 3H), 2.37 (s, 3H), 1.20 - 1.08 (m, 3H)。 19 F NMR (376 MHz, DMSO-d 6 ) δ - 61.02。 | |
402 | 75-79 | ESIMSm/z 355 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.94 - 7.72 (m, 2H), 7.00 - 6。85 (m, 1H), 4.35 - 4.22 (m, 2H), 3.54 - 3.36 (m, 2H), 3.08 - 2.90 (m, 3H), 2.47 (s, 3H), 1.19- 1.02 (m, 5H), 0.05 (m, 9H)。 | |
403 | 50-54 | ESIMSm/z 351 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.93 - 7.74 (m, 2H), 7.02 - 6.88 (m, 1H), 4.02 (d,J = 6.0 Hz, 2H), 3.53 - 3.36 (m, 2H), 3.09 - 2.90 (m, 3H), 2.47 (s, 3H), 1.82 - 1.58 (m, 6H), 1.32 - 0.96 (m, 8H)。 | |
404 | 52-56 | ESIMSm/z 337 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.92 - 7.74 (m, 2H), 6.97 - 6.85 (m, 1H), 4.10 (d,J = 7.2 Hz, 2H), 3.54 - 3.36 (m, 2H), 3.08 - 2.92 (m, 3H), 2.49 (s, 3H), 2.34 - 2.22 (m, 1H), 1.84 - 1.70 (m, 2H),1.68 - 1.46 (m, 4H),1.38 - 1.26 (m, 2H), 1.24 - 1.08 (m, 3H)。 | |
405 | ESIMSm/z 309 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.94 - 7.72 (m, 2H), 6.98 - 6.86 (m, 1H), 4.04 (d,J = 7.2 Hz, 2H), 3.52 - 3.38 (m, 2H), 3.10 - 2.92 (m, 3H), 2.48 (s, 3H), 1.34 - 1.04 (m, 4H), 0.68 - 0.48 (m, 2H), 0.42 - 0.36 (m, 2H)。 | ||
406 | 80-84 | ESIMSm/z 345 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.95 - 7.76 (m, 2H), 7.02 - 6.90 (m, 1H), 4.46 - 4.32 (m, 1H), 4.25 - 4.12 (m, 1H), 3.55 - 3.36 (m, 2H), 3.10 - 2.90 (m, 3H), 2.48 (s, 3H), 2.32 - 2.14 (m, 1H), 1.82 - 1.66 (m, 1H), 1.62 - 1.48 (m, 1H), 1.22 - 1.08 (m, 3H)。 19 F NMR (376 MHz, DMSO-d 6 ) δ - 127.74 (dt,J = 154.5, 11.3 Hz, 1F), - 141.98 (ddd,J = 158.2, 15.1, 3.8 Hz, 1F)。 | |
407 | 93-97 | ESIMSm/z 351 ([M+H]+ ) | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.95 - 7.75 (m, 2H), 7.02 - 6.90 (m, 1H), 4.41 (t,J = 5.6 Hz, 2H), 3.54 - 3.36 (m, 2H), 3.08 - 2.90 (m, 3H), 2.90 - 2.72 (m, 2H), 2.48 (s, 3H), 1.22 - 1.08 (m, 3H)。 19 F NMR (376 MHz, DMSO-d 6 ) δ - 63.33。 | |
408 | (薄膜)3258, 2973, 1702, 1633, 1594, 1371, 1248, 1109, 1080, 760, 728 | 對於C24 H33 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為381.2537;實測值為381.2532 | 1 H NMR(500 MHz, CDCl3 ) δ 7.79 (s, 1H), 7.45 (d,J = 43.6 Hz, 1H), 7.26 (dd,J = 7.9, 1.5 Hz, 1H), 7.22 - 7.14 (m, 2H), 7.10 (td,J = 7.3, 1.4 Hz, 1H), 6.59 (s, 1H), 5.33 (dq,J = 8.7, 6.2 Hz, 1H), 3.52 (s, 1H), 3.43 - 3.21 (m, 2H), 3.02 (s, 3H), 2.56 (s, 3H), 2.38 (s, 3H), 2.28 (s, 3H), 1.32 (d,J = 6.9 Hz, 3H), 1.22 (t,J = 7.2 Hz, 3H), 1.17 (d,J = 6.3 Hz, 3H)。 13 C NMR (126 MHz, CDCl3 ) δ 167.32, 154.46, 142.37, 139.38, 135.65, 132.51, 130.41, 128.77, 126.51, 126.28, 126.06, 123.05, 121.99, 74.66, 47.90, 40.17, 32.01, 30.95, 21.84, 20.11, 18.64, 18.33, 17.53, 14.40。 | |
409 | (薄膜)2972, 2929, 1702, 1631, 1592, 1548, 1369, 1246, 1108, 1078, 728 | 對於C24 H33 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為381.2537;實測值為381.2535 | 1 H NMR(500 MHz, CDCl3 ) δ 7.79 (s, 1H), 7.45 (d,J = 43.4 Hz, 1H), 7.31 - 7.22 (m, 1H), 7.22 - 7.14 (m, 2H), 7.10 (td,J = 7.3, 1.4 Hz, 1H), 6.59 (s, 1H), 5.33 (dq,J = 8.8, 6.2 Hz, 1H), 3.30 (dq,J = 8.8, 6.9 Hz, 3H), 3.02 (s, 3H), 2.57 (s, 3H), 2.38 (s, 3H), 2.28 (s, 3H), 1.32 (d,J = 6.9 Hz, 3H), 1.22 (t,J = 7.1 Hz, 3H), 1.17 (d,J = 6.3 Hz, 3H)。 13 C NMR (126 MHz, CDCl3 ) δ 167.31, 154.47, 142.37, 139.38, 135.64, 132.51, 130.41, 128.76, 126.50, 126.28, 126.05, 123.04, 121.99, 74.66, 47.89, 40.16, 30.94, 29.80, 21.83, 20.11, 18.63, 18.33, 17.52, 14.47。 | |
410 | ESIMSm/z 473 [(M+2H)+ ] | 1 H NMR(400 MHz, CDCl3 ) δ 7.97 (s, 1H), 7.69 (s, 1H), 7.62 (dd,J = 13.8, 7.7 Hz, 2H), 7.52 (t,J = 7.7 Hz, 1H), 7.14 (s, 1H), 5.35 (s, 2H), 3.63 - 3.21 (m, 2H), 3.08 - 2.97 (m, 3H), 2.46 (s, 3H), 2.19 (s, 3H), 1.25 (d,J = 6.3 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 62.63。 | ||
411 | ESIMSm/z 423 [(M+2H)+ ] | 1 H NMR(400 MHz, CDCl3 ) δ 7.95 (s, 1H), 7.47 (td,J = 7.5, 1.8 Hz, 1H), 7.33 (tdd,J = 7.5, 5.3, 1.8 Hz, 1H), 7.25 - 7.22 (m, 1H), 7.16 (td,J = 7.5, 1.2 Hz, 1H), 7.10 (ddd,J = 9.6, 8.2, 1.2 Hz, 1H), 5.37 (d,J = 1.1 Hz, 2H), 3.63 - 3.24 (m, 2H), 3.10 - 2.92 (m, 3H), 2.45 (s, 3H), 2.18 (s, 3H), 1.23 (t,J = 7.3 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 117.80。 | ||
412 | ESIMSm/z 435 [(M+H)+ ] | 1 H NMR(400 MHz, CDCl3 ) δ 7.87 (s, 1H), 7.26 - 7.20 (m, 1H), 7.12 (s, 1H), 7.01 (d,J = 7.6 Hz, 1H), 6.95 (t,J = 8.9 Hz, 1H), 5.38 (d,J = 1.7 Hz, 2H), 3.62 - 3.19 (m, 2H), 3.07 - 2.95 (m, 3H), 2.45 (s, 3H), 2.44 (s, 3H), 2.18 (s, 3H), 1.43 - 1.10 (m, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 117.36。 | ||
413 | ESIMSm/z 491 [(M+2H)+ ] | 1 H NMR(400 MHz, CDCl3 ) δ 7.96 (s, 1H), 7.78 - 7.64 (m, 1H), 7.65 - 7.56 (m, 1H), 7.27 (t,J = 7.8 Hz, 1H), 7.14 (s, 1H), 5.41 (d,J = 1.4 Hz, 2H), 3.67 - 3.18 (m, 2H), 3.10 - 2.94 (m, 3H), 2.46 (s, 3H), 2.19 (s, 3H), 1.24 (t,J = 6.7 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 61.28 (d,J = 12.5 Hz), - 119.36 (q,J = 12.9 Hz)。 | ||
414 | ESIMSm/z 375 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.76 (s, 1H), 7.44 (d,J = 41.3 Hz, 1H), 7.29 (d,J = 8.4 Hz, 1H), 6.80 (t,J = 9.6 Hz, 1H), 6.57 (s, 1H), 5.28 (s, 2H), 3.42 (d,J = 97.6 Hz, 2H), 3.01 (s, 3H), 2.54 (s, 3H), 2.29 - 2.15 (m, 6H), 1.23 (q,J = 8.9, 7.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 113.09 (d,J = 8.7 Hz), -118.03 (d,J = 8.6 Hz)。 | ||
415 | ESIMSm/z 379 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.71 (s, 1H), 7.43 (d,J = 39.0 Hz, 1H), 6.75 - 6.68 (m, 2H), 6.56 (s, 1H), 5.32 (d,J = 1.4 Hz, 2H), 3.42 (d,J = 97.7 Hz, 2H), 3.01 (s, 3H), 2.52 (s, 3H), 2.21 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 106.59 (t,J = 7.8 Hz), - 110.87 (t,J = 7.3 Hz)。 | ||
416 | (薄膜)2975, 2934, 1725, 1629, 1580, 1370, 1290, 1171, 1108, 1018, 807, 732 | 對於C21 H24 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為393.1784;實測值為393.1780 | 1 H NMR(400 MHz, CDCl3 ) δ 7.40 (s, 1H), 7.31 (d,J = 8.1 Hz, 2H), 7.24 (d,J = 8.4 Hz, 1H), 7.17 (d,J = 7.7 Hz, 2H), 6.84 (d,J = 8.1 Hz, 1H), 5.25 (s, 2H), 3.60 - 3.22 (m, 2H), 3.02 (s, 3H), 2.45 - 2.38 (m, 3H), 2.35 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 55.79。 | |
417 | (薄膜)2974, 2924, 1727, 1631, 1591, 1556, 1370, 1244, 1108, 992 | 對於C21 H24 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為393.1784;實測值為393.1782 | 1 H NMR(400 MHz, CDCl3 ) δ 7.66 (s, 1H), 7.55 - 7.38 (m, 1H), 7.34 (d,J = 8.0 Hz, 2H), 7.19 (d,J = 7.8 Hz, 2H), 7.05 (s, 1H), 5.29 (s, 2H), 3.63 - 3.26 (m, 2H), 3.03 (s, 3H), 2.36 (s, 3H), 2.29 (s, 3H), 1.28 - 1.17 (m, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 58.83。 | |
418 | (薄膜)2977, 2937, 1729, 1630, 1580, 1330, 1166, 1120, 1019, 701 | 對於C21 H21 F6 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為447.1502;實測值為447.1499 | 1 H NMR(400 MHz, CDCl3 ) δ 7.68 (s, 1H), 7.60 (t,J = 6.9 Hz, 2H), 7.49 (t,J = 7.7 Hz, 1H), 7.45 - 7.30 (m, 1H), 7.29 - 7.26 (m, 1H), 6.87 (d,J = 8.1 Hz, 1H), 5.34 (s, 2H), 3.62 - 3.26 (m, 2H), 3.03 (s, 3H), 2.42 (q,J = 2.6 Hz, 3H), 1.23 (t,J = 7.1 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 55.78, - 62.71。 | |
419 | (薄膜)2978, 2936, 1729, 1633, 1592, 1246, 1111, 908, 733 | 對於C21 H21 F6 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為447.1502;實測值為447.1498 | 1 H NMR(400 MHz, CDCl3 ) δ 7.69 (d,J = 10.6 Hz, 2H), 7.61 (dd,J = 13.5, 7.7 Hz, 2H), 7.55 - 7.37 (m, 2H), 7.07 (s, 1H), 5.37 (s, 2H), 3.61 - 3.27 (m, 2H), 3.04 (s, 3H), 2.31 (s, 3H), 1.30 - 1.15 (m, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 58.87, - 62.69。 | |
420 | (薄膜)2975, 2935, 1729, 1630, 1581, 1372, 1292, 1171, 1109, 1019, 757 | 對於C20 H21 F4 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為397.1534;實測值為397.1536 | 1 H NMR(400 MHz, CDCl3 ) δ 7.46 (td,J = 7.5, 1.8 Hz, 1H), 7.43 - 7.29 (m, 2H), 7.28 - 7.25 (m, 1H), 7.14 (td,J = 7.5, 1.2 Hz, 1H), 7.08 (ddd,J = 9.6, 8.1, 1.2 Hz, 1H), 6.86 (d,J = 8.1 Hz, 1H), 5.37 (s, 2H), 3.61 - 3.19 (m, 2H), 3.02 (s, 3H), 2.44 - 2.37 (m, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 55.88, - 117.96。 | |
421 | (薄膜)2974, 2933, 1729, 1631, 1590, 1556, 1371, 1243, 1108, 757 | 對於C20 H21 F4 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為397.1534;實測值為397.1531 | 1 H NMR(400 MHz, CDCl3 ) δ 7.68 (s, 1H), 7.53 - 7.38 (m, 2H), 7.38 - 7.29 (m, 1H), 7.15 (td,J = 7.5, 1.2 Hz, 1H), 7.12 - 7.04 (m, 2H), 5.40 (s, 2H), 3.59 - 3.29 (m, 2H), 3.03 (s, 3H), 2.30 (s, 3H), 1.24 (dd,J = 10.6, 3.9 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 58.95, - 117.90。 | |
422 | (薄膜)2977, 2936, 1732, 1631, 1581, 1478, 1329, 1292, 1124, 1019, 974 | 對於C21 H20 F7 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為465.1408;實測值為465.1406 | 1 H NMR(400 MHz, CDCl3 ) δ 7.72 - 7.65 (m, 1H), 7.63 - 7.55 (m, 1H), 7.44 - 7.30 (m, 1H), 7.30 - 7.21 (m, 2H), 6.87 (d,J = 8.1 Hz, 1H), 5.40 (d,J = 1.4 Hz, 2H), 3.62 - 3.23 (m, 2H), 3.03 (s, 3H), 2.41 (d,J = 2.6 Hz, 3H), 1.23 (t,J = 7.2 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 55.86, - 61.35 (d,J = 12.5 Hz), - 119.33 (q,J = 12.8 Hz)。 | |
423 | (薄膜)2977, 2934, 1733, 1632, 1591, 1373, 1246, 1110, 1000 | 對於C21 H20 F7 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為465.1408;實測值為465.1407 | 1 H NMR(400 MHz, CDCl3 ) δ 7.74 - 7.66 (m, 2H), 7.64 - 7.56 (m, 1H), 7.54 - 7.39 (m, 1H), 7.30 - 7.22 (m, 1H), 7.07 (s, 1H), 5.44 (d,J = 1.4 Hz, 2H), 3.64 - 3.28 (m, 2H), 3.04 (s, 3H), 2.31 (s, 3H), 1.25 (t,J = 7.5 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 58.98, - 61.33 (d,J = 12.5 Hz), -119.33 (q,J = 12.8 Hz)。 | |
424 | ESIMSm/z 439 [(M+H)+ ] | 1 H NMR(500 MHz, CDCl3 ) δ 7.82 - 7.78 (m, 1H), 7.71 (d,J = 1.8 Hz, 1H), 7.64 (d,J = 7.6 Hz, 1H), 7.59 (d,J = 7.8 Hz, 1H), 7.51 (t,J = 7.7 Hz, 1H), 6.68 (s, 1H), 5.35 (s, 2H), 3.57 (q,J = 7.1 Hz, 2H), 3.08 (s, 3H), 2.54 (s, 3H), 2.14 (s, 3H), 1.94 (s, 3H), 1.20 (t,J = 7.0 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 62.60。 | ||
425 | ESIMSm/z 354 [(M+H)+ ] | 1 H NMR(600 MHz, CDCl3 ) δ 7.55 (s, 1H), 7.38 - 7.29 (m, 2H), 7.18 (d,J = 7.8 Hz, 2H), 7.08 (s, 1H), 5.26 (s, 2H), 3.63 - 3.15 (m, 2H), 3.00 (s, 3H), 2.47 (s, 3H), 2.36 (s, 3H), 2.10 (s, 3H), 2.09 (s, 3H), 1.31 - 0.95 (m, 3H)。 | ||
426 | ESIMSm/z 408 [(M+H)+ ] | 1 H NMR(600 MHz, CDCl3 ) δ 7.71 (d,J = 2.0 Hz, 1H), 7.64 (d,J = 7.6 Hz, 1H), 7.61 - 7.56 (m, 2H), 7.50 (t,J = 7.7 Hz, 1H), 7.09 (s, 1H), 5.35 (s, 2H), 3.68 - 3.13 (m, 2H), 3.00 (s, 3H), 2.48 (s, 3H), 2.12 (s, 3H), 2.11 (s, 3H), 1.21 (t,J = 7.2 Hz, 3H)。 19 F NMR (564 MHz, CDCl3 ) δ - 62.63。 | ||
427 | ESIMSm/z 358 [(M+H)+ ] | 1 H NMR(600 MHz, CDCl3 ) δ 7.56 (s, 1H), 7.48 (td,J = 7.5, 1.8 Hz, 1H), 7.31 (tdd,J = 7.5, 5.3, 1.8 Hz, 1H), 7.15 (td,J = 7.5, 1.2 Hz, 1H), 7.12 - 7.03 (m, 2H), 5.37 (d,J = 1.1 Hz, 2H), 3.69 - 3.14 (m, 2H), 3.00 (s, 3H), 2.47 (s, 3H), 2.11 (s, 3H), 2.10 (s, 3H), 1.30 - 1.09 (m, 3H)。 19 F NMR (564 MHz, CDCl3 ) δ - 117.87 - - 117.95 (m)。 | ||
428 | ESIMSm/z 372 [(M+H)+ ] | 1 H NMR(600 MHz, CDCl3 ) δ 7.48 (s, 1H), 7.22 (td,J = 8.0, 5.8 Hz, 1H), 7.06 (s, 1H), 7.00 (d,J = 7.6 Hz, 1H), 6.94 (t,J = 8.9 Hz, 1H), 5.38 (d,J = 1.7 Hz, 2H), 3.65 - 3.15 (m, 2H), 2.99 (s, 3H), 2.46 (s, 3H), 2.45 (s, 3H), 2.10 (s, 3H), 2.07 (s, 3H), 1.30 - 1.09 (m, 3H)。 19 F NMR (564 MHz, CDCl3 ) δ - 117.41 - - 117.46 (m)。 | ||
429 | ESIMSm/z 426 [(M+H)+ ] | 1 H NMR(600 MHz, CDCl3 ) δ 7.75 - 7.65 (m, 1H), 7.61 - 7.56 (m, 2H), 7.26 (t,J = 7.8 Hz, 1H), 7.09 (s, 1H), 5.41 (d,J = 1.3 Hz, 2H), 3.64 - 3.15 (m, 2H), 3.01 (s, 3H), 2.47 (s, 3H), 2.12 (s, 3H), 2.11 (s, 3H), 1.29 - 1.06 (m, 3H)。 19 F NMR (564 MHz, CDCl3 ) δ - 61.28 (d,J = 13.5 Hz), - 119.43 (qt,J = 13.1, 6.6 Hz)。 | ||
430 | 對於C20 H21 F4 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為429.1254;實測值為429.1254 | 1 H NMR(400 MHz, CDCl3 ) δ 7.49 - 7.42 (m, 2H), 7.37 - 7.30 (m, 2H), 7.15 (td,J = 7.5, 1.2 Hz, 1H), 7.09 (ddd,J = 9.7, 8.2, 1.2 Hz, 1H), 6.80 - 6.75 (m, 1H), 5.39 (s, 2H), 3.88 (q,J = 7.1 Hz, 2H), 3.28 (s, 3H), 2.37 (d,J = 2.2 Hz, 3H), 1.31 (t,J = 7.2 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 56.01, - 117.87。 | ||
431 | 對於C20 H21 F4 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為429.1254;實測值為429.1251 | 1 H NMR(400 MHz, CDCl3 ) δ 7.71 (s, 1H), 7.66 (s, 1H), 7.47 (td,J = 7.5, 1.8 Hz, 1H), 7.39 - 7.30 (m, 1H), 7.16 (td,J = 7.5, 1.2 Hz, 1H), 7.10 (ddd,J = 9.7, 8.3, 1.2 Hz, 1H), 6.76 (s, 1H), 5.42 (s, 2H), 3.89 (q,J = 7.1 Hz, 2H), 3.26 (s, 3H), 2.33 (s, 3H), 1.31 (t,J = 7.2 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 59.25, - 117.84。 | ||
432 | (薄膜)2965, 2927, 1709, 1632, 1593, 1546, 1370, 1248, 1108, 1082, 757 | 對於C22 H28 FN2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為371.2129;實測值為371.2131 | 1 H NMR(400 MHz, CDCl3 ) δ 7.65 (s, 1H), 7.53 - 7.38 (m, 2H), 7.32 (tdd,J = 7.4, 5.2, 1.8 Hz, 1H), 7.15 (td,J = 7.6, 1.2 Hz, 1H), 7.09 (ddd,J = 9.7, 8.2, 1.2 Hz, 1H), 6.72 (s, 1H), 5.37 (d,J = 1.1 Hz, 2H), 3.85 (p,J = 6.8 Hz, 1H), 3.61 - 3.19 (m, 2H), 3.01 (s, 3H), 2.21 (s, 3H), 1.28 - 1.17 (m, 9H)。 19 F NMR (376 MHz, CDCl3 ) δ - 117.95。 | |
433 | (薄膜)2966, 2929, 1710, 1633, 1594, 1546, 1329, 1246, 1163, 1108, 1082, 790 | 對於C23 H28 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為421.2097;實測值為421.2102 | 1 H NMR(400 MHz, CDCl3 ) δ 7.72 - 7.66 (m, 2H), 7.61 (dd,J = 16.8, 7.8 Hz, 2H), 7.53 - 7.40 (m, 2H), 6.73 (s, 1H), 5.35 (s, 2H), 3.85 (p,J = 6.8 Hz, 1H), 3.66 - 3.24 (m, 2H), 3.02 (s, 3H), 2.23 (s, 3H), 1.30 - 1.17 (m, 9H)。 19 F NMR (376 MHz, CDCl3 ) δ - 62.66。 | |
434 | 110-112 | 對於C20 H24 N3 O4 計算的HRMS-ESI (m/z ) [M+H]+ 為370.1761;實測值為370.1763 | 1 H NMR(400 MHz, CDCl3 ) δ 8.18 - 8.10 (m, 1H), 7.85 (s, 1H), 7.73 - 7.58 (m, 2H), 7.53 - 7.39 (m, 2H), 6.60 (s, 1H), 5.73 (s, 2H), 3.68 - 3.26 (m, 2H), 3.03 (s, 3H), 2.55 (s, 3H), 2.27 (s, 3H), 1.23 (t,J = 7.1 Hz, 3H)。 | |
435 | 對於C20 H21 F4 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為397.1534;實測值為397.1535 | 1 H NMR(400 MHz, CDCl3 ) δ 8.25 - 8.17 (m, 1H), 7.69 - 7.30 (m, 3H), 7.20 - 7.05 (m, 2H), 6.78 - 6.66 (m, 1H), 5.45 - 5.32 (m, 2H), 3.61 - 3.25 (m, 2H), 3.04 (s, 3H), 2.67 - 2.51 (m, 3H), 1.35 - 1.10 (m, 3H)(多個構象的混合物)。 19 F NMR (376 MHz, CDCl3 ) δ - 60.94, - 61.10, - 117.86(多個構象的混合物)。 | ||
436 | (薄膜)2935, 1716, 1635, 1597, 1546, 1330, 1229, 1167, 1117, 1074, 780 | 對於C21 H21 F6 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為447.1502;實測值為447.1509 | 1 H NMR(400 MHz, CDCl3 ) δ 8.27 - 8.19 (m, 1H), 7.70 (s, 1H), 7.66 - 7.43 (m, 4H), 6.80 - 6.66 (m, 1H), 5.52 - 5.19 (m, 2H), 3.60 - 3.26 (m, 2H), 3.04 (s, 3H), 2.61 (s, 3H), 1.28 - 1.13 (m, 3H)(多個構象的混合物)。 19 F NMR (376 MHz, CDCl3 ) δ - 60.99, - 62.69(多個構象的混合物)。 | |
437 | (薄膜)2975, 2932, 1712, 1635, 1597, 1546, 1370, 1229, 1172, 1116, 1080 | 對於C21 H24 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為393.1784;實測值為393.1787 | 1 H NMR(400 MHz, CDCl3 ) δ 8.27 - 8.16 (m, 1H), 7.69 - 7.30 (m, 3H), 7.19 (d,J = 8.0 Hz, 2H), 6.77 - 6.63 (m, 1H), 5.33 - 5.26 (m, 2H), 3.62 - 3.23 (m, 2H), 3.03 (s, 3H), 2.69 - 2.50 (m, 3H), 2.36 (s, 3H), 1.34 - 1.12 (m, 3H)(多個構象的混合物)。 19 F NMR (376 MHz, CDCl3 ) δ - 60.87, - 61.04(多個構象的混合物)。 | |
438 | (薄膜)2977, 2937, 1729, 1630, 1580, 1325, 1292, 1168, 1109, 1066, 1019, 824 | 對於C21 H21 F6 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為447.1502;實測值為447.1506 | 1 H NMR(400 MHz, CDCl3 ) δ 7.63 (d,J = 8.1 Hz, 2H), 7.53 (d,J = 8.1 Hz, 2H), 7.44 - 7.31 (m, 1H), 7.28 - 7.26 (m, 1H), 6.87 (d,J = 8.1 Hz, 1H), 5.34 (s, 2H), 3.65 - 3.23 (m, 2H), 3.03 (s, 3H), 2.49 - 2.35 (m, 3H), 1.23 (t,J = 7.2 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 55.75, - 62.62。 | |
439 | (薄膜)2978, 2937, 1731, 1630, 1581, 1330, 1292, 1169, 1123, 1019, 908 | 對於C21 H20 F7 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為465.1408;實測值為465.1415 | 1 H NMR(400 MHz, CDCl3 ) δ 7.60 (t,J = 7.5 Hz, 1H), 7.46 - 7.31 (m, 3H), 7.29 - 7.25 (m, 1H), 6.87 (d,J = 8.1 Hz, 1H), 5.40 (s, 2H), 3.61 - 3.22 (m, 2H), 3.03 (s, 3H), 2.47 - 2.32 (m, 3H), 1.23 (t,J = 7.1 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 55.83, - 62.83, - 115.39。 | |
440 | (薄膜)2975, 2934, 1730, 1629, 1580, 1479, 1372, 1291, 1171, 1124, 1108, 1018 | 對於C21 H22 F5 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為429.1596;實測值為429.1601 | 1 H NMR(400 MHz, CDCl3 ) δ 7.46 - 7.29 (m, 1H), 7.26 - 7.23 (m, 1H), 7.14 - 7.02 (m, 1H), 6.93 (t,J = 7.3 Hz, 1H), 6.85 (d,J = 8.1 Hz, 1H), 5.33 (s, 2H), 3.65 - 3.22 (m, 2H), 3.02 (s, 3H), 2.43 - 2.37 (m, 3H), 2.30 (d,J = 2.2 Hz, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 55.87, - 142.49 (d,J = 20.5 Hz), - 143.51 (d,J = 20.8 Hz)。 | |
441 | 對於C21 H21 F6 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為447.1502;實測值為447.1504 | 1 H NMR(400 MHz, CDCl3 ) δ 7.69 (s, 1H), 7.64 (d,J = 8.1 Hz, 2H), 7.58 - 7.40 (m, 3H), 7.07 (s, 1H), 5.38 (s, 2H), 3.67 - 3.26 (m, 2H), 3.04 (s, 3H), 2.31 (s, 3H), 1.35 - 0.98 (m, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 58.85, - 62.61。 | ||
442 | (薄膜)2976, 2936, 1716, 1633, 1577, 1372, 1240, 1205, 1110, 1080, 1035, 756 | 對於C20 H21 F4 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為397.1534;實測值為397.1537 | 1 H NMR(400 MHz, CDCl3 ) δ 7.78 (d,J = 8.4 Hz, 1H), 7.46 (td,J = 7.5, 1.8 Hz, 1H), 7.38 - 7.29 (m, 2H), 7.16 (t,J = 7.5 Hz, 1H), 7.10 (t,J = 9.1 Hz, 1H), 6.65 (d,J = 8.4 Hz, 1H), 5.38 (s, 2H), 3.57 - 3.22 (m, 2H), 3.00 (s, 3H), 2.62 (q,J = 3.3 Hz, 3H), 1.20 (s, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 51.77, - 51.94, - 117.76(多個構象的混合物)。 | |
443 | (薄膜)2978, 2938, 1717, 1634, 1578, 1330, 1240, 1204, 1164, 1115, 1074, 1036 | 對於C21 H21 F6 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為447.1502;實測值為447.1507 | 1 H NMR(400 MHz, CDCl3 ) δ 7.79 (d,J = 8.5 Hz, 1H), 7.69 (s, 1H), 7.62 (t,J = 7.9 Hz, 2H), 7.51 (t,J = 7.7 Hz, 1H), 7.39 - 7.26 (m, 1H), 6.75 - 6.62 (m, 1H), 5.36 (s, 2H), 3.62 - 3.18 (m, 2H), 3.01 (s, 3H), 2.63 (t,J = 3.3 Hz, 3H), 1.21 (d,J = 7.4 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 51.80, - 62.66。 | |
444 | (薄膜)2975, 2935, 1713, 1633, 1578, 1370, 1240, 1205, 1111, 1081, 1035 | 對於C21 H24 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為393.1784;實測值為393.1789 | 1 H NMR(400 MHz, CDCl3 ) δ 7.77 (d,J = 8.5 Hz, 1H), 7.36 - 7.29 (m, 3H), 7.19 (d,J = 7.7 Hz, 2H), 6.64 (d,J = 8.4 Hz, 1H), 5.28 (s, 2H), 3.56 - 3.20 (m, 2H), 3.00 (s, 3H), 2.62 (d,J = 3.4 Hz, 3H), 2.36 (s, 3H), 1.21 (t,J = 7.1 Hz, 3H)(多個構象的混合物)。 19 F NMR (376 MHz, CDCl3 ) δ - 51.76, - 51.93(多個構象的混合物)。 | |
445 | (薄膜)2978, 2939, 1720, 1634, 1578, 1476, 1375, 1329, 1241, 1205, 1113, 1082, 1036 | 對於C21 H20 F7 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為465.1408;實測值為465.1412 | 1 H NMR(400 MHz, CDCl3 ) δ 7.85 - 7.76 (m, 1H), 7.69 (t,J = 7.2 Hz, 1H), 7.61 (t,J = 7.2 Hz, 1H), 7.40 - 7.24 (m, 2H), 6.71 - 6.61 (m, 1H), 5.42 (s, 2H), 3.64 - 3.23 (m, 2H), 3.01 (s, 3H), 2.63 (q,J = 3.3 Hz, 3H), 1.22 (t,J = 7.6 Hz, 3H)(多個構象的混合物)。 19 F NMR (376 MHz, CDCl3 ) δ - 51.80, - 61.31 (d,J = 13.7 Hz), - 119.26 (q,J = 13.1 Hz)(多個構象的混合物)。 | |
446 | 對於C21 H21 F6 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為447.1502;實測值為447.1506 | 1 H NMR(400 MHz, CDCl3 ) δ 7.80 (d,J = 8.4 Hz, 1H), 7.65 (d,J = 8.0 Hz, 2H), 7.55 (d,J = 7.9 Hz, 2H), 7.41 - 7.26 (m, 1H), 6.72 - 6.61 (m, 1H), 5.37 (s, 2H), 3.71 - 3.21 (m, 2H), 3.03 - 2.96 (m, 3H), 2.63 (q,J = 3.4 Hz, 3H), 1.22 (t,J = 7.6 Hz, 3H)(多個構象的混合物)。 19 F NMR (376 MHz, CDCl3 ) δ - 51.79, - 62.62, - 62.65(多個構象的混合物)。 | ||
447 | (薄膜)2978, 2937, 1719, 1636, 1597, 1546, 1328, 1224, 1169, 1115, 1079 | 對於C21 H20 F7 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為465.1408;實測值為465.1416 | 1 H NMR(400 MHz, CDCl3 ) δ 8.27 - 8.18 (m, 1H), 7.76 - 7.42 (m, 3H), 7.33 - 7.26 (m, 1H), 6.81 - 6.65 (m, 1H), 5.48 - 5.39 (m, 2H), 3.66 - 3.24 (m, 2H), 3.04 (s, 3H), 2.68 - 2.56 (m, 3H), 1.30 - 1.07 (m, 3H)(多個構象的混合物)。 19 F NMR (376 MHz, CDCl3 ) δ - 61.01, - 61.31 (d,J = 12.6 Hz), - 119.39 (q,J = 13.1 Hz)(多個構象的混合物)。 | |
448 | (薄膜)2978, 2937, 1717, 1636, 1598, 1546, 1324, 1230, 1170, 1113, 1082, 1066, 1019, 823 | 對於C21 H21 F6 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為447.1502;實測值為447.1506 | 1 H NMR(400 MHz, CDCl3 ) δ 8.28 - 8.21 (m, 1H), 7.69 - 7.38 (m, 5H), 6.81 - 6.68 (m, 1H), 5.44 - 5.34 (m, 2H), 3.62 - 3.26 (m, 3H), 3.04 (s, 3H), 2.67 - 2.56 (m, 3H), 1.30 - 1.15 (m, 2H)(多個構象的混合物)。 19 F NMR (376 MHz, CDCl3 ) δ - 60.98, - 61.15, - 62.60, - 62.63(多個構象的混合物)。 | |
449 | (薄膜)2965, 2924, 1706, 1633, 1594, 1547, 1247, 1108, 1083, 789 | 對於C23 H31 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為367.238;實測值為367.2384 | 1 H NMR(400 MHz, CDCl3 ) δ 7.65 (s, 1H), 7.43 (s, 1H), 7.34 (d,J = 7.9 Hz, 2H), 7.19 (d,J = 7.9 Hz, 2H), 6.72 (s, 1H), 5.26 (s, 2H), 3.87 (p,J = 6.8 Hz, 1H), 3.61 - 3.24 (m, 2H), 3.01 (s, 3H), 2.36 (s, 3H), 2.21 (s, 3H), 1.26 - 1.19 (m, 9H)。 | |
450 | 對於C21 H20 F7 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為465.1408;實測值為465.1410 | 1 H NMR(400 MHz, CDCl3 ) δ 7.69 (s, 1H), 7.62 (t,J = 7.6 Hz, 1H), 7.54 - 7.41 (m, 2H), 7.37 (d,J = 9.7 Hz, 1H), 7.07 (s, 1H), 5.43 (s, 2H), 3.73 - 3.20 (m, 2H), 3.04 (s, 3H), 2.31 (s, 3H), 1.28 - 1.18 (m, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 58.95, - 62.82, - 115.35。 | ||
451 | 對於C21 H22 F5 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為429.1596;實測值為429.1601 | 1 H NMR(400 MHz, CDCl3 ) δ 7.66 (s, 1H), 7.52 - 7.36 (m, 1H), 7.11 (t,J = 7.3 Hz, 1H), 7.05 (s, 1H), 6.93 (t,J = 7.4 Hz, 1H), 5.36 (s, 2H), 3.66 - 3.26 (m, 2H), 3.03 (d,J = 1.5 Hz, 3H), 2.39 - 2.15 (m, 6H), 1.24 (t,J = 7.4 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 58.96, - 142.46 (d,J = 20.4 Hz), - 143.48 (d,J = 20.3 Hz)。 | ||
452 | 對於C21 H20 F7 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為465.1408;實測值為465.1415 | 1 H NMR(400 MHz, CDCl3 ) δ 8.22 (s, 1H), 7.71 - 7.41 (m, 3H), 7.37 (d,J = 9.8 Hz, 1H), 6.79 - 6.65 (m, 1H), 5.43 (s, 2H), 3.65 - 3.14 (m, 2H), 3.04 (s, 3H), 2.61 (s, 3H), 1.42 - 1.02 (m, 3H)(多個構象的混合物)。 19 F NMR (376 MHz, CDCl3 ) δ - 61.02, - 62.81, - 115.34(多個構象的混合物)。 | ||
453 | 對於C21 H22 F5 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為429.1596;實測值為429.1601 | 1 H NMR(400 MHz, CDCl3 ) δ 8.20 (s, 1H), 7.68 - 7.38 (m, 1H), 7.10 (t,J = 7.2 Hz, 1H), 6.94 (t,J = 7.3 Hz, 1H), 6.77 - 6.65 (m, 1H), 5.35 (s, 2H), 3.64 - 3.14 (m, 2H), 3.03 (d,J = 1.1 Hz, 3H), 2.60 (s, 3H), 2.31 (d,J = 2.2 Hz, 3H), 1.22 (dt,J = 15.9, 7.2 Hz, 3H)(多個構象的混合物)。 19 F NMR (376 MHz, CDCl3 ) δ - 60.95, - 142.31 (d,J = 20.6 Hz), - 143.50 (d,J = 19.7 Hz)。 | ||
454 | 對於C21 H20 F7 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為465.1408;實測值為465.1412 | 1 H NMR(400 MHz, CDCl3 ) δ 7.80 (d,J = 8.4 Hz, 1H), 7.60 (t,J = 7.5 Hz, 1H), 7.44 (d,J = 8.0 Hz, 1H), 7.41 - 7.32 (m, 2H), 6.67 (d,J = 8.4 Hz, 1H), 5.42 (s, 2H), 3.62 - 3.18 (m, 2H), 3.01 (s, 3H), 2.65 - 2.61 (m, 3H), 1.29 - 1.10 (m, 3H)(多個構象的混合物)。 19 F NMR (376 MHz, CDCl3 ) δ - 51.80, - 62.83, - 115.21(多個構象的混合物)。 | ||
455 | 對於C21 H22 F5 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為429.1596;實測值為429.1602 | 1 H NMR(400 MHz, CDCl3 ) δ 7.76 (d,J = 8.5 Hz, 1H), 7.35 (s, 1H), 7.09 (t,J = 7.2 Hz, 1H), 6.94 (t,J = 7.3 Hz, 1H), 6.69 - 6.56 (m, 1H), 5.34 (s, 2H), 3.62 - 3.21 (m, 2H), 3.00 (d,J = 1.4 Hz, 3H), 2.61 (d,J = 3.5 Hz, 3H), 2.31 (d,J = 2.2 Hz, 3H), 1.30 - 1.13 (m, 3H)(多個構象的混合物)。 19 F NMR (376 MHz, CDCl3 ) δ - 51.79, - 142.23 (d,J = 20.0 Hz), - 143.38 (d,J = 20.5 Hz)(多個構象的混合物)。 | ||
456 | (薄膜)2974, 2935, 1710, 1631, 1575, 1250, 1140, 1064, 841 | 對於C20 H24 F5 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為451.1473;實測值為451.1479 | 1 H NMR(400 MHz, CDCl3 ) δ 7.84 (s, 1H), 7.76 - 7.63 (m, 2H), 7.59 (d,J = 7.7 Hz, 1H), 7.52 - 7.37 (m, 2H), 6.63 (d,J = 8.4 Hz, 1H), 5.35 (s, 2H), 3.62 - 3.19 (m, 2H), 3.02 (s, 3H), 2.52 (s, 3H), 2.28 (s, 3H), 1.27 - 1.13 (m, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ 87.70 - 79.33 (m), 65.49 - 57.60 (m)。 | |
457 | (薄膜)2974, 2927, 1708, 1632, 1592, 1370, 1246, 1108, 841 | 對於C20 H24 F5 N2 O2 S計算的HRMS-ESI (m/z ) [M+H]+ 為451.1473;實測值為451.1481 | 1 H NMR(400 MHz, CDCl3 ) δ 7.85 (s, 1H), 7.79 (s, 1H), 7.72 (d,J = 8.3 Hz, 1H), 7.60 (d,J = 7.7 Hz, 1H), 7.54 - 7.34 (m, 2H), 6.58 (s, 1H), 5.35 (s, 2H), 3.64 - 3.18 (m, 2H), 3.02 (s, 3H), 2.55 (s, 3H), 2.24 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ 85.95 - 82.73 (m), 63.31 - 61.10 (m)。 | |
458 | ESIMSm/z 361 [(M+2H)+ ] | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.74 (d,J = 45.7 Hz, 1H), 7.59 - 7.50 (m, 1H), 7.34 (d,J = 7.6 Hz, 2H), 7.20 (d,J = 7.5 Hz, 2H), 6.86 (t,J = 9.5 Hz, 1H), 5.24 (s, 2H), 3.47 (q,J = 7.7 Hz, 1H), 3.39 (dd,J = 7.1, 3.3 Hz, 1H), 2.99 (d,J = 24.2 Hz, 3H), 2.31 (d,J = 3.5 Hz, 6H), 1.33 - 1.01 (m, 3H)。 | ||
459 | ESIMSm/z 415 [(M+2H)+ ] | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.93 - 7.46 (m, 6H), 6.89 (t,J = 9.7 Hz, 1H), 5.40 (s, 2H), 3.54 - 3.36 (m, 2H), 3.00 (d,J = 25.2 Hz, 3H), 2.32 (d,J = 3.1 Hz, 3H), 1.31 - 0.93 (m, 3H)。 | ||
460 | ESIMSm/z 365 [(M+2H)+ ] | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.74 (d,J = 45.2 Hz, 1H), 7.62 - 7.49 (m, 2H), 7.44 (q,J = 7.5, 6.9 Hz, 1H), 7.36 - 7.17 (m, 2H), 6.88 (d,J = 9.0 Hz, 1H), 5.34 (s, 2H), 3.47 (q,J = 7.9 Hz, 1H), 3.38 (d,J = 8.6 Hz, 1H), 2.99 (d,J = 24.5 Hz, 3H), 2.31 (d,J = 3.0 Hz, 3H), 1.34 - 0.98 (m, 3H)。 | ||
461 | (薄膜)2971, 2932, 1716, 1630, 1575, 1367, 1254, 1122, 1074, 1004, 758 | 對於C20 H24 FN2 O3 計算的HRMS-ESI (m/z ) [M+H]+ 為359.1765;實測值為359.1771 | 1 H NMR(400 MHz, CDCl3 ) δ 7.69 (d,J = 8.4 Hz, 1H), 7.55 - 7.38 (m, 2H), 7.31 (q,J = 7.2 Hz, 1H), 7.15 (t,J = 7.5 Hz, 1H), 7.12 - 7.04 (m, 1H), 6.56 (d,J = 8.4 Hz, 1H), 5.40 (s, 2H), 3.75 (d,J = 1.2 Hz, 3H), 3.62 - 3.20 (m, 2H), 3.02 (s, 3H), 2.23 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 117.92。 | |
462 | (薄膜)2973, 2934, 1716, 1631, 1575, 1329, 1254, 1118, 1072, 1003, 792 | 對於C21 H24 F3 N2 O3 計算的HRMS-ESI (m/z ) [M+H]+ 為409.1734;實測值為409.1736 | 1 H NMR(400 MHz, CDCl3 ) δ 7.75 - 7.67 (m, 2H), 7.65 (d,J = 7.7 Hz, 1H), 7.58 (d,J = 7.8 Hz, 1H), 7.54 - 7.34 (m, 2H), 6.58 (d,J = 8.4 Hz, 1H), 5.38 (s, 2H), 3.75 (s, 3H), 3.64 - 3.20 (m, 2H), 3.03 (s, 3H), 2.24 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 62.63。 | |
463 | (薄膜)2971, 2930, 1715, 1630, 1575, 1366, 1283, 1253, 1120, 1073, 1004, 972 | 對於C21 H27 N2 O3 計算的HRMS-ESI (m/z ) [M+H]+ 為355.2016;實測值為355.2018 | 1 H NMR(400 MHz, CDCl3 ) δ 7.67 (d,J = 8.4 Hz, 1H), 7.48 (s, 1H), 7.35 (d,J = 7.6 Hz, 2H), 7.18 (d,J = 7.7 Hz, 2H), 6.54 (d,J = 8.4 Hz, 1H), 5.29 (s, 2H), 3.74 (d,J = 1.4 Hz, 3H), 3.62 - 3.18 (m, 2H), 3.02 (s, 3H), 2.35 (s, 3H), 2.23 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 | |
464 | (薄膜)2915, 1713, 1423, 1326, 1122, 909, 736 | 對於C15 H20 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為317.1471;實測值為317.1466 | 1 H NMR(500 MHz, CDCl3 ) δ 7.80 (s, 1H), 7.57 - 7.34 (m, 1H), 6.59 (s, 1H), 4.65 (dq,J = 14.4, 8.5 Hz, 2H), 3.43 (d,J = 96.6 Hz, 2H), 3.03 (s, 3H), 2.55 (s, 3H), 2.25 (s, 3H), 1.27 - 1.17 (m, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 73.50 (t,J = 8.6 Hz)。 | |
465 | (薄膜)2943, 1694, 1425, 1375, 1328, 1165, 1126, 1038, 918, 735 | 對於C16 H22 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為331.1628;實測值為331.1627 | 1 H NMR(500 MHz, CDCl3 ) δ 7.76 (s, 1H), 7.48 (s, 1H), 6.57 (s, 1H), 4.47 (t,J = 6.4 Hz, 2H), 3.42 (d,J = 94.1 Hz, 2H), 3.02 (s, 3H), 2.60 (dddd,J = 17.0, 10.6, 6.4, 3.7 Hz, 2H), 2.54 (s, 3H), 2.24 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 64.90 (d,J = 21.6 Hz)。 | |
466 | (薄膜)1713, 1364, 1327, 1224, 1128, 1030, 915, 736 | 對於C18 H26 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為359.1941;實測值為359.1935 | 1 H NMR(500 MHz, CDCl3 ) δ 7.74 (s, 1H), 7.48 (s, 1H), 6.57 (s, 1H), 4.28 (t,J = 6.3 Hz, 2H), 3.42 (d,J = 91.8 Hz, 2H), 3.02 (s, 3H), 2.54 (s, 3H), 2.25 (s, 3H), 2.23 - 2.10 (m, 2H), 1.95 - 1.80 (m, 2H), 1.80 - 1.65 (m, 2H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 66.36 (t,J = 10.9 Hz)。 | |
467 | (薄膜)2972, 2925, 1708, 1631, 1592, 1547, 1368, 1253, 1108, 1086, 907 | 對於C17 H25 F2 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為327.1879;實測值為327.1874 | 1 H NMR(500 MHz, CDCl3 ) δ 7.74 (s, 1H), 7.48 (s, 1H), 6.57 (s, 1H), 4.44 (t,J = 6.7 Hz, 2H), 3.42 (d,J = 93.6 Hz, 2H), 3.02 (s, 3H), 2.54 (s, 3H), 2.35 (tt,J = 15.4, 6.7 Hz, 2H), 2.24 (s, 3H), 1.69 (t,J = 18.6 Hz, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 89.25 - - 89.56 (m)。 | |
468 | (薄膜)2971, 2930, 1709, 1635, 1594, 1256, 1110, 918 | 對於C18 H27 F2 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為341.2035;實測值為341.2028 | 1 H NMR(500 MHz, CDCl3 ) δ 7.74 (s, 1H), 7.47 (s, 1H), 6.57 (s, 1H), 4.30 (t,J = 6.1 Hz, 2H), 3.42 (d,J = 94.4 Hz, 2H), 3.02 (s, 3H), 2.54 (s, 3H), 2.25 (s, 3H), 2.15 - 1.85 (m, 4H), 1.63 (t,J = 18.4 Hz, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 91.13 (qt,J = 18.2, 15.4 Hz)。 | |
469 | (薄膜)2972, 2928, 1709, 1634, 1594, 1549, 1251, 1110, 1087, 953, 780 | 對於C18 H24 BrClF3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為471.0656;實測值為471.0645 | 1 H NMR(500 MHz, CDCl3 ) δ 7.74 (s, 1H), 7.47 (s, 1H), 6.58 (s, 1H), 4.42 - 4.27 (m, 2H), 3.42 (d,J = 94.3 Hz, 2H), 3.02 (s, 3H), 2.59 - 2.48 (m, 4H), 2.44 - 2.06 (m, 6H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 60.72 (dd,J = 11.6, 6.7 Hz), - 117.66 - - 118.09 (m)。 | |
470 | (薄膜)2972, 2926, 1708, 1633, 1593, 1549, 1370, 1250, 1142, 1109, 1087, 906 | 對於C18 H24 BrF4 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為455.0952;實測值為455.0945 | 1 H NMR(500 MHz, CDCl3 ) δ 7.74 (s, 1H), 7.47 (s, 1H), 6.58 (s, 1H), 4.33 (t,J = 6.3 Hz, 2H), 3.42 (d,J = 92.6 Hz, 2H), 3.02 (s, 3H), 2.54 (s, 3H), 2.35 - 2.19 (m, 5H), 2.17 - 2.00 (m, 2H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 65.55 - - 65.61 (m), -111.98 (tt,J = 18.2, 3.9 Hz)。 | |
471 | (薄膜)2973, 2926, 1713, 1636, 1594, 1256, 1196, 1110, 1086, 736 | 對於C17 H22 F5 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為381.1596;實測值為381.1590 | 1 H NMR(500 MHz, CDCl3 ) δ 7.75 (s, 1H), 7.45 (s, 1H), 6.57 (s, 1H), 4.54 (t,J = 6.6 Hz, 2H), 3.42 (d,J = 95.2 Hz, 2H), 3.02 (s, 3H), 2.66 - 2.44 (m, 5H), 2.24 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 85.65, - 117.38 (t,J = 17.8 Hz)。 | |
472 | (薄膜)2974, 2932, 1726, 1636, 1595, 1259, 1201, 1108, 736 | 對於C16 H20 F5 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為367.1439;實測值為367.1436 | 1 H NMR(500 MHz, CDCl3 ) δ 7.79 (s, 1H), 7.47 (s, 1H), 6.59 (s, 1H), 4.70 (td,J = 13.0, 1.2 Hz, 2H), 3.43 (d,J = 97.5 Hz, 2H), 3.02 (s, 3H), 2.55 (s, 3H), 2.25 (s, 3H), 1.33 - 1.13 (m, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 83.73 (d,J = 4.1 Hz), - 123.10 (t,J = 13.0 Hz)。 | |
473 | (薄膜)2972, 2929, 1711, 1635, 1594, 1549, 1247, 1109, 736 | 對於C17 H23 F2 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為325.1722;實測值為325.1717 | 1 H NMR(500 MHz, CDCl3 ) δ 7.75 (s, 1H), 7.48 (d,J = 11.6 Hz, 1H), 6.58 (s, 1H), 5.09 (dddq,J = 9.5, 5.6, 3.7, 1.8 Hz, 1H), 3.43 (d,J = 95.9 Hz, 2H), 3.20 - 3.05 (m, 2H), 3.02 (s, 3H), 2.87 - 2.71 (m, 2H), 2.54 (s, 3H), 2.25 (s, 3H), 1.23 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 84.71 (dtd,J = 199.4, 13.2, 6.5 Hz), -95.90 - -97.65 (m)。 | |
474 | (薄膜)2926, 1707, 1631, 1591, 1547, 1295, 1247, 1108, 1085, 922, 781 | 對於C18 H25 F2 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為339.1879;實測值為339.1879 | 1 H NMR(500 MHz, CDCl3 ) δ 7.75 (s, 1H), 7.48 (s, 1H), 6.57 (s, 1H), 4.31 (d,J = 6.3 Hz, 2H), 3.42 (d,J = 93.9 Hz, 2H), 3.02 (s, 3H), 2.81 - 2.67 (m, 2H), 2.67 - 2.57 (m, 1H), 2.57 - 2.38 (m, 5H), 2.24 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 83.35 (ddddd,J = 193.5, 20.8, 12.4, 8.0, 4.2 Hz), -93.91 (dp,J = 194.0, 14.3 Hz)。 | |
475 | (薄膜)2937, 1706, 1632, 1592, 1548, 1364, 1248, 1108, 1085, 972, 782 | 對於C20 H29 F2 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為367.2192;實測值為367.2190 | 1 H NMR(500 MHz, CDCl3 ) δ 7.74 (s, 1H), 7.48 (s, 1H), 6.57 (s, 1H), 4.14 (d,J = 6.3 Hz, 2H), 3.42 (d,J = 93.5 Hz, 2H), 3.02 (s, 3H), 2.54 (s, 3H), 2.25 (s, 3H), 2.14 (ddt,J = 17.5, 7.3, 2.8 Hz, 2H), 1.91 (tt,J = 15.9, 8.0 Hz, 3H), 1.75 (dtt,J = 32.0, 13.7, 4.3 Hz, 2H), 1.44 (qd,J = 12.6, 12.2, 3.7 Hz, 2H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 91.65 (d,J = 235.9 Hz), - 102.06 (d,J = 231.6 Hz)。 | |
476 | (薄膜)2974, 2927, 1714, 1635, 1593, 1507, 1262, 1109, 1087, 736 | 對於C20 H21 F4 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為397.1534;實測值為397.1531 | 1 H NMR(500 MHz, CDCl3 ) δ 7.72 (s, 1H), 7.47 (s, 1H), 7.09 (tt,J = 9.7, 7.3 Hz, 1H), 6.56 (s, 1H), 5.40 (t,J = 1.6 Hz, 2H), 3.42 (d,J = 93.6 Hz, 2H), 3.01 (s, 3H), 2.53 (s, 3H), 2.22 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 138.89 (ddd,J = 22.4, 13.3, 9.8 Hz), -142.50 (ddd,J = 21.5, 13.4, 7.3 Hz)。 | |
477 | (薄膜)2971, 2925, 1709, 1631, 1591, 1547, 1513, 1487, 1369, 1244, 1107, 1085, 781 | 對於C20 H22 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為379.1628;實測值為379.1630 | 1 H NMR(500 MHz, CDCl3 ) δ 7.76 (s, 1H), 7.42 (s, 1H), 7.21 (tdd,J = 7.9, 5.6, 2.5 Hz, 1H), 6.97 (tdd,J = 9.1, 6.9, 2.1 Hz, 1H), 6.57 (s, 1H), 5.33 (d,J = 1.4 Hz, 2H), 3.42 (d,J = 95.0 Hz, 2H), 3.01 (s, 3H), 2.53 (s, 3H), 2.23 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 134.00 - -134.30 (m), -137.98 (dt,J = 20.3, 7.5 Hz), - 160.21 - - 160.51 (m)。 | |
478 | (薄膜)2924, 1704, 1631, 1592, 1529, 1246, 1109, 1087, 1041, 776 | 對於C20 H22 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為379.1628;實測值為379.1627 | 1 H NMR(500 MHz, CDCl3 ) δ 7.78 (s, 1H), 7.56 - 7.37 (m, 1H), 7.11 - 7.03 (m, 2H), 6.58 (s, 1H), 5.21 (s, 2H), 3.43 (d,J = 95.9 Hz, 2H), 3.02 (s, 3H), 2.54 (s, 3H), 2.25 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 133.89 - - 134.02 (m), - 161.33 (tt,J = 20.3, 6.5 Hz)。 | |
479 | (薄膜)2974, 2928, 1713, 1634, 1593, 1506, 1245, 1108, 1045, 934 | 對於C20 H20 F5 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為415.1439;實測值為415.1442 | 1 H NMR(500 MHz, CDCl3 ) δ 7.70 (s, 1H), 7.59 - 7.36 (m, 1H), 6.56 (s, 1H), 5.37 (t,J = 1.6 Hz, 2H), 3.42 (d,J = 95.5 Hz, 2H), 3.01 (s, 3H), 2.52 (s, 3H), 2.22 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 141.71 (dd,J = 21.9, 8.6 Hz), - 153.11 (t,J = 20.7 Hz), - 161.75 (td,J = 21.3, 20.8, 8.1 Hz)。 | |
480 | (薄膜)2972, 2926, 1712, 1633, 1592, 1548, 1489, 1369, 1244, 1107, 1085, 875, 780 | 對於C21 H23 F4 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為411.1690;實測值為411.1695 | 1 H NMR(500 MHz, CDCl3 ) δ 7.71 (s, 1H), 7.58 - 7.33 (m, 1H), 6.56 (s, 1H), 5.37 (d,J = 1.5 Hz, 2H), 3.41 (d,J = 90.0 Hz, 2H), 3.01 (s, 3H), 2.52 (s, 3H), 2.29 (t,J = 2.1 Hz, 3H), 2.21 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 143.77 (dd,J = 22.1, 13.0 Hz), - 144.31 (dd,J = 21.8, 13.0 Hz)。 | |
481 | (薄膜)2970, 2924, 1710, 1630, 1589, 1546, 1258, 1244, 1107, 970, 779 | 對於C18 H23 N4 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為327.1816;實測值為327.1812 | 1 H NMR(500 MHz, CDCl3 ) δ 9.20 (d,J = 1.4 Hz, 1H), 8.74 (d,J = 5.2 Hz, 1H), 7.89 (s, 1H), 7.61 - 7.46 (m, 1H), 7.44 (dd,J = 5.2, 1.4 Hz, 1H), 6.61 (s, 1H), 5.41 (s, 2H), 3.44 (d,J = 96.7 Hz, 2H), 3.03 (s, 3H), 2.58 (s, 3H), 2.27 (s, 3H), 1.23 (t,J = 7.2 Hz, 3H)。 | |
482 | (薄膜)2970, 2924, 1708, 1629, 1590, 1545, 1367, 1243, 1107, 1085, 1047, 732 | 對於C19 H25 N4 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為341.1972;實測值為341.1969 | 1 H NMR(500 MHz, CDCl3 ) δ 7.82 (s, 1H), 7.53 (d,J = 8.6 Hz, 1H), 7.48 (d,J = 10.7 Hz, 1H), 7.34 (d,J = 8.6 Hz, 1H), 6.59 (s, 1H), 5.61 (s, 2H), 3.42 (d,J = 92.7 Hz, 2H), 3.02 (s, 3H), 2.73 (s, 3H), 2.56 (s, 3H), 2.24 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 | |
483 | (薄膜)2971, 2924, 1710, 1631, 1592, 1547, 1368, 1255, 1108, 1086 | 對於C18 H23 N4 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為327.1816;實測值為327.1810 | 1 H NMR(500 MHz, CDCl3 ) δ 8.78 (d,J = 1.6 Hz, 1H), 8.58 (dd,J = 2.6, 1.5 Hz, 1H), 8.54 (d,J = 2.6 Hz, 1H), 7.85 (s, 1H), 7.50 (s, 1H), 6.59 (s, 1H), 5.47 (s, 2H), 3.43 (d,J = 96.3 Hz, 2H), 3.02 (s, 3H), 2.57 (s, 3H), 2.25 (s, 3H), 1.23 (t,J = 7.2 Hz, 3H)。 | |
484 | (薄膜)2970, 2924, 1708, 1629, 1590, 1545, 1368, 1243, 1107, 1085, 1060, 971, 780 | 對於C18 H23 N4 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為327.1816;實測值為327.1808 | 1 H NMR(500 MHz, CDCl3 ) δ 9.16 (dd,J = 4.9, 1.7 Hz, 1H), 7.89 - 7.79 (m, 1H), 7.65 (dd,J = 8.5, 1.7 Hz, 1H), 7.58 - 7.33 (m, 2H), 6.60 (s, 1H), 5.67 (s, 2H), 3.43 (d,J = 94.9 Hz, 2H), 3.02 (s, 3H), 2.57 (s, 3H), 2.25 (s, 3H), 1.23 (t,J = 7.1 Hz, 3H)。 | |
485 | (薄膜)2971, 2925, 1710, 1631, 1592, 1565, 1432, 1369, 1258, 1242, 1110, 1087, 779 | 對於C18 H23 N4 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為327.1816;實測值為327.1808 | 1 H NMR(500 MHz, CDCl3 ) δ 8.74 (d,J = 4.9 Hz, 2H), 7.92 (s, 1H), 7.48 (s, 1H), 7.21 (t,J = 4.9 Hz, 1H), 6.58 (s, 1H), 5.51 (s, 2H), 3.42 (d,J = 91.6 Hz, 2H), 3.02 (s, 3H), 2.57 (s, 3H), 2.25 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 | |
486 | (薄膜)2971, 2924, 1709, 1631, 1591, 1547, 1450, 1368, 1254, 1108, 1086, 1049, 802, 780 | 對於C19 H23 FN3 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為344.1769;實測值為344.1766 | 1 H NMR(500 MHz, CDCl3 ) δ 8.44 (dt,J = 4.6, 1.5 Hz, 1H), 7.87 - 7.77 (m, 1H), 7.57 - 7.35 (m, 2H), 7.30 (dt,J = 8.5, 4.4 Hz, 1H), 6.56 (s, 1H), 5.48 (d,J = 2.1 Hz, 2H), 3.41 (d,J = 91.5 Hz, 2H), 3.01 (d,J = 3.7 Hz, 3H), 2.54 (d,J = 2.4 Hz, 3H), 2.21 (s, 3H), 1.22 (td,J = 7.1, 3.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 124.40 - - 124.46 (m)。 | |
487 | ESIMSm/z 361 [(M+2H)+ ] | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.76 (d,J = 45.3 Hz, 1H), 7.64 (d,J = 8.5 Hz, 1H), 7.39 - 7.29 (m, 2H), 7.21 (d,J = 7.9 Hz, 2H), 6.90 (t,J = 8.6 Hz, 1H), 5.24 (s, 2H), 3.43 (dd,J = 40.3, 7.1 Hz, 2H), 3.00 (d,J = 22.6 Hz, 3H), 2.56 (s, 3H), 2.31 (s, 3H), 1.15 (td,J = 7.2, 2.2 Hz, 3H)。 | ||
488 | ESIMSm/z 415 [(M+2H)+ ] | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.87 - 7.60 (m, 6H), 6.93 (t,J = 8.9 Hz, 1H), 5.39 (s, 2H), 3.43 (dq,J = 40.0, 7.3 Hz, 2H), 3.01 (d,J = 23.1 Hz, 3H), 2.58 (s, 3H), 1.28 - 1.05 (m, 3H)。 19 F NMR (376 MHz, DMSO-d 6 ) δ - 61.10。 | ||
489 | ESIMSm/z 364 [(M+2H)+ ] | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.76 (d,J = 45.2 Hz, 1H), 7.64 (d,J = 8.5 Hz, 1H), 7.56 (td,J = 7.6, 1.7 Hz, 1H), 7.50 - 7.38 (m, 1H), 7.35 - 7.20 (m, 2H), 6.90 (t,J = 8.6 Hz, 1H), 5.34 (s, 2H), 3.53 - 3.35 (m, 2H), 3.00 (d,J = 22.5 Hz, 3H), 2.56 (s, 3H), 1.15 (td,J = 7.2, 2.4 Hz, 3H)。 19 F NMR (376 MHz, DMSO-d 6 ) δ - 118.14。 | ||
490 | ESIMSm/z 344 [(M+2H)+ ] | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.84 (d,J = 37.0 Hz, 1H), 7.57 (dd,J = 8.5, 1.3 Hz, 1H), 7.41 - 7.28 (m, 2H), 7.21 (d,J = 7.8 Hz, 2H), 6.91 (td,J = 8.5, 4.3 Hz, 1H), 5.23 (s, 2H), 3.51 - 3.34 (m, 2H), 2.98 (d,J = 31.0 Hz, 3H), 2.41 (d,J = 2.7 Hz, 3H), 2.31 (s, 3H), 1.13 (dt,J = 12.2, 7.1 Hz, 3H)。 19 F NMR (376 MHz, DMSO-d 6 ) δ - 130.63 (d,J = 18.8 Hz)。 | ||
491 | ESIMSm/z 398 [(M+2H)+ ] | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.93 - 7.59 (m, 6H), 6.94 (td,J = 8.5, 4.7 Hz, 1H), 5.38 (s, 2H), 3.53 - 3.35 (m, 2H), 2.99 (d,J = 30.8 Hz, 3H), 2.42 (d,J = 2.7 Hz, 3H), 1.13 (dt,J = 12.4, 7.1 Hz, 3H)。 19 F NMR (376 MHz, DMSO-d 6 ) δ - 61.10, - 130.53。 | ||
492 | ESIMSm/z 348 [(M+2H)+ ] | 1 H NMR(400 MHz, DMSO-d 6 ) δ 7.84 (d,J = 37.0 Hz, 1H), 7.56 (ddd,J = 7.7, 6.5, 1.5 Hz, 2H), 7.51 - 7.37 (m, 1H), 7.33 - 7.14 (m, 2H), 6.91 (td,J = 8.5, 4.2 Hz, 1H), 5.34 (s, 2H), 3.52 - 3.35 (m, 2H), 2.98 (d,J = 31.0 Hz, 3H), 2.42 (dd,J = 12.2, 2.7 Hz, 3H), 1.13 (dt,J = 12.3, 7.1 Hz, 3H)。 19 F NMR (376 MHz, DMSO-d 6 ) δ - 118.16, - 130.54。 | ||
493 | 172-176 | 對於C21 H24 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為393.1784,實測值為393.1793 | 1 H NMR(500 MHz, CDCl3 ) δ 12.64 - 12.53 (m, 1H), 7.95 - 7.86 (m, 1H), 7.70 - 7.65 (m, 1H), 7.65 - 7.57 (m, 3H), 7.56 - 7.49 (m, 1H), 7.28 - 7.22 (m, 0.6H), 5.37 (s, 2H), 4.00 (q,J = 7.2 Hz, 0.6H), 3.64 (q,J = 7.2 Hz, 1.4H), 3.50 (s, 2H), 3.33 (s, 1H), 2.44 (s, 3H), 2.38 (s, 3H), 1.36 - 1.28 (m, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 62.64。 | |
494 | 152-159 | 對於C21 H24 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為393.1784,實測值為393.1788 | 1 H NMR(400 MHz, CDCl3 ) δ 12.81 - 12.74 (m, 1H), 7.81 (s, 1H), 7.75 - 7.67 (m, 2H), 7.67 - 7.58 (m, 2H), 7.57 - 7.49 (m, 1H), 7.25 - 7.18 (m, 1H), 5.37 (s, 2H), 4.18 - 4.12 (m, 0.6H), 3.68 - 3.61 (m, 3.4H), 3.36 (s, 0.7H), 2.52 (s, 3H), 2.50 (s, 3H), 1.46 - 1.35 (m, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 62.67。 | |
495 | 125-129 | 對於C20 H24 FN2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為343.1816,實測值為343.1819 | 1 H NMR(500 MHz, CDCl3 ) δ 12.59 - 12.53 (m, 1H), 8.05 - 7.93 (m, 1H), 7.77 - 7.72 (m, 1H), 7.49 - 7.42 (m, 1H), 7.39 - 7.31 (m, 1H), 7.28 - 7.21 (m, 1H), 7.20 - 7.12 (m, 1H), 7.15 - 7.06 (m, 1H), 5.38 (s, 2H), 4.04 (q,J = 7.0 Hz, 0.6H), 3.67 (q,J = 7.1 Hz, 1.3H), 3.53 (s, 2H), 3.36 (s, 0.8H), 2.49 (s, 3H), 2.45 (s, 3H), 1.37 - 1.30 (m, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 117.81。 | |
496 | ESIMSm/z 379 [(M+H)+ ] | 1 H NMR (400 MHz, CDCl3 ) δ 7.60 (d,J = 8.4 Hz, 1H), 7.40 (s, 1H), 6.74 - 6.64 (m, 2H), 6.58 (d,J = 8.3 Hz, 1H), 5.32 (s, 2H), 3.60 - 3.22 (m, 2H), 3.01 (s, 3H), 2.49 (s, 3H), 2.26 (s, 3H), 1.21 (t,J = 7.1 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 106.57 (t,J = 7.0 Hz), - 110.91 (d,J = 6.9 Hz)。 | ||
497 | (薄膜)2965, 2934, 2875, 1716, 1634, 1591, 1554, 1494, 1456, 1370, 1236, 1109, 1065, 1001, 972 | 對於C22 H28 FN2 O3 計算的HRMS-ESI (m/z ) [M+H]+ 為387.2078;實測值為387.2080 | 1 H NMR (400 MHz, CDCl3 ) δ 7.68 (d,J = 0.9 Hz, 1H), 7.53 (td,J = 7.5, 1.9 Hz, 1H), 7.44 (s, 1H), 7.36 - 7.26 (m, 1H), 7.13 (td,J = 7.5, 1.2 Hz, 1H), 7.07 (ddd,J = 9.7, 8.2, 1.2 Hz, 1H), 6.31 (s, 1H), 5.38 (d,J = 1.2 Hz, 2H), 3.94 (t,J = 6.6 Hz, 2H), 3.65 - 3.17 (m, 2H), 3.01 (s, 3H), 2.17 (s, 3H), 1.79 (dtd,J = 13.9, 7.4, 6.5 Hz, 2H), 1.22 (t,J = 7.1 Hz, 3H), 0.98 (t,J = 7.4 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 118.01。 | |
498 | (薄膜)2968, 2935, 2877, 1635, 1591, 1555, 1329, 1237, 1162, 1110, 1073, 1001 | 對於C23 H28 F3 N2 O3 計算的HRMS-ESI (m/z ) [M+H]+ 為437.2047;實測值為437.2047 | 1 H NMR (400 MHz, CDCl3 ) δ 7.77 - 7.66 (m, 2H), 7.65 (d,J = 7.7 Hz, 1H), 7.57 (d,J = 7.8 Hz, 1H), 7.52 - 7.30 (m, 2H), 6.32 (s, 1H), 5.36 (s, 2H), 3.96 (t,J = 6.6 Hz, 2H), 3.62 - 3.23 (m, 2H), 3.02 (s, 3H), 2.18 (s, 3H), 1.87 - 1.68 (m, 2H), 1.23 (t,J = 7.1 Hz, 3H), 0.97 (t,J = 7.4 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 62.59。 | |
499 | (薄膜)2925, 1714, 1634, 1591, 1369, 1237, 1108, 1066, 1000 | 對於C23 H31 N2 O3 計算的HRMS-ESI (m/z ) [M+H]+ 為383.2329;實測值為383.2332 | 1 H NMR (400 MHz, CDCl3 ) δ 7.68 - 7.64 (m, 1H), 7.44 (s, 1H), 7.35 (d,J = 8.0 Hz, 2H), 7.17 (d,J = 7.7 Hz, 2H), 6.31 (s, 1H), 5.27 (s, 2H), 3.95 (t,J = 6.6 Hz, 2H), 3.59 - 3.25 (m, 2H), 3.01 (s, 3H), 2.35 (s, 3H), 2.16 (s, 3H), 1.86 - 1.73 (m, 2H), 1.22 (t,J = 7.2 Hz, 3H), 0.99 (t,J = 7.4 Hz, 3H)。 | |
500 | (薄膜)2973, 2930, 1712, 1631, 1575, 1536, 1362, 1252, 1139, 1064 | 對於C20 H23 FN3 O4 計算的HRMS-ESI (m/z ) [M+H]+ 為388.1667;實測值為388.1669 | 1 H NMR (500 MHz, CDCl3 ) δ 7.76 (dd,J = 8.2, 1.2 Hz, 1H), 7.53 (d,J = 8.4 Hz, 1H), 7.52 - 7.46 (m, 1H), 7.42 - 7.35 (m, 2H), 6.58 (d,J = 8.4 Hz, 1H), 5.62 (d,J = 1.6 Hz, 2H), 3.72 - 3.12 (m, 2H), 3.01 (s, 3H), 2.48 (s, 3H), 2.25 (s, 3H), 1.21 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 111.81。 | |
501 | (薄膜)2972, 2933, 1708, 1629, 1574, 1364, 1250, 1141, 1062, 1028, 971 | 對於C21 H25 F2 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為375.1879;實測值為375.1881 | 1 H NMR (500 MHz, CDCl3 ) δ 7.69 (d,J = 8.3 Hz, 1H), 7.59 - 7.53 (m, 2H), 7.51 - 7.40 (m, 3H), 6.66 (t,J = 56.5 Hz, 1H), 6.62 (d,J = 8.3 Hz, 1H), 5.34 (s, 2H), 3.60 - 3.21 (m, 2H), 3.02 (s, 3H), 2.52 (s, 3H), 2.28 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 110.78。 | |
502 | ESIMSm/z 387 [(M+H)+ ] | 1 H NMR (400 MHz, CDCl3 ) δ 7.80 - 7.56 (m, 1H), 7.52 (s, 1H), 7.47 (td,J = 7.5, 1.8 Hz, 1H), 7.31 (tdd,J = 7.4, 5.2, 1.8 Hz, 1H), 7.14 (td,J = 7.5, 1.2 Hz, 1H), 7.08 (ddd,J = 9.6, 8.2, 1.2 Hz, 1H), 6.71 (s, 1H), 5.38 (d,J = 1.1 Hz, 2H), 3.92 (t,J = 6.6 Hz, 2H), 3.61 - 3.21 (m, 2H), 3.01 (s, 3H), 2.50 (s, 3H), 1.80 (h,J = 7.2 Hz, 2H), 1.21 (t,J = 7.2 Hz, 3H), 1.01 (t,J = 7.4 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 117.92。 | ||
503 | (薄膜)2967, 2932, 1711, 1633, 1583, 1329, 1110, 1073, 971 | 對於C23 H28 F3 N2 O3 計算的HRMS-ESI (m/z ) [M+H]+ 為437.2047;實測值為437.2052 | 1 H NMR (400 MHz, CDCl3 ) δ 7.80 - 7.69 (m, 2H), 7.65 - 7.56 (m, 2H), 7.55 - 7.46 (m, 2H), 6.73 (s, 1H), 5.36 (s, 2H), 3.93 (t,J = 6.6 Hz, 2H), 3.61 - 3.21 (m, 2H), 3.02 (s, 3H), 2.52 (s, 3H), 1.80 (p,J = 7.1 Hz, 2H), 1.22 (t,J = 7.1 Hz, 3H), 1.01 (t,J = 7.4 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 62.67。 | |
504 | ESIMSm/z 455 [(M+H)+ ] | 1 H NMR (400 MHz, CDCl3 ) δ 7.76 (t,J = 7.3 Hz, 1H), 7.69 (d,J = 0.8 Hz, 1H), 7.60 - 7.52 (m, 1H), 7.50 - 7.34 (m, 1H), 7.25 - 7.19 (m, 1H), 6.31 (s, 1H), 5.44 - 5.38 (m, 2H), 3.95 (t,J = 6.6 Hz, 2H), 3.60 - 3.23 (m, 2H), 3.02 (s, 3H), 2.18 (s, 3H), 1.78 (dtd,J = 13.9, 7.4, 6.5 Hz, 2H), 1.23 (t,J = 7.2 Hz, 3H), 0.97 (t,J = 7.4 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 61.26 (d,J = 13.7 Hz), - 119.49 (q,J = 12.7 Hz)。 | ||
505 | ESIMSm/z 455 [(M+H)+ ] | 1 H NMR (400 MHz, CDCl3 ) δ 7.73 - 7.65 (m, 2H), 7.50 - 7.39 (m, 2H), 7.34 (dd,J = 9.7, 1.7 Hz, 1H), 6.32 (s, 1H), 5.42 (s, 2H), 3.96 (t,J = 6.5 Hz, 2H), 3.70 - 3.17 (m, 2H), 3.02 (s, 3H), 2.18 (s, 3H), 1.80 (dtd,J = 13.8, 7.4, 6.5 Hz, 2H), 1.23 (t,J = 7.1 Hz, 3H), 0.98 (t,J = 7.4 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 62.74, - 115.58。 | ||
506 | (薄膜)2964, 2928, 1708, 1632, 1583, 1371, 1251, 1109, 1085, 970 | 對於C23 H31 N2 O3 計算的HRMS-ESI (m/z ) [M+H]+ 為383.2329;實測值為383.2330 | 1 H NMR (400 MHz, CDCl3 ) δ 7.73 (s, 1H), 7.52 (s, 1H), 7.34 (d,J = 8.0 Hz, 2H), 7.18 (d,J = 7.8 Hz, 2H), 6.71 (s, 1H), 5.28 (s, 2H), 3.91 (t,J = 6.6 Hz, 2H), 3.68 - 3.17 (m, 2H), 3.02 (s, 3H), 2.50 (s, 3H), 2.36 (s, 3H), 1.79 (h,J = 7.2 Hz, 2H), 1.21 (t,J = 7.2 Hz, 3H), 1.01 (t,J = 7.4 Hz, 3H)。 | |
507 | (薄膜)2927, 1708, 1633, 1592, 1520, 1246, 1109, 1086, 776 | 對於C20 H23 F2 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為361.1722;實測值為361.1732 | 1 H NMR (500 MHz, CDCl3 ) δ 7.78 (s, 1H), 7.55 - 7.36 (m, 1H), 7.31 - 7.24 (m, 1H), 7.21 - 7.11 (m, 2H), 6.58 (s, 1H), 5.24 (s, 2H), 3.42 (d,J = 95.0 Hz, 2H), 3.02 (s, 3H), 2.54 (s, 3H), 2.24 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 137.32 - -137.65 (m), - 138.59 - - 139.16 (m)。 | |
508 | (薄膜)2927, 1710, 1631, 1593, 1548, 1247, 1109, 1086, 850 | 對於C20 H23 F2 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為361.1722;實測值為361.1733 | 1 H NMR (500 MHz, CDCl3 ) δ 7.81 (s, 1H), 7.60 - 7.39 (m, 1H), 7.00 - 6.92 (m, 2H), 6.75 (tt,J = 9.0, 2.4 Hz, 1H), 6.59 (s, 1H), 5.27 (s, 2H), 3.43 (d,J = 95.9 Hz, 2H), 3.02 (s, 3H), 2.56 (s, 3H), 2.25 (s, 3H), 1.23 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 109.42 - - 109.64 (m)。 | |
509 | (薄膜)2926, 1712, 1634, 1593, 1548, 1500, 1247, 1109, 780 | 對於C20 H22 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為379.1628;實測值為379.1640 | 1 H NMR (500 MHz, CDCl3 ) δ 7.79 (s, 1H), 7.45 (d,J = 37.3 Hz, 1H), 6.99 (dp,J = 8.1, 2.4 Hz, 1H), 6.95 - 6.87 (m, 1H), 6.58 (s, 1H), 5.36 (d,J = 1.5 Hz, 2H), 3.43 (d,J = 95.9 Hz, 2H), 3.02 (s, 3H), 2.55 (s, 3H), 2.25 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 114.61 - - 115.47 (m), - 133.47 (ddt,J = 20.8, 10.1, 2.8 Hz), - 147.62 (ddt,J = 20.6, 15.0, 5.6 Hz)。 | |
510 | (薄膜)2927, 1710, 1633, 1592, 1498, 1250, 1108, 1086, 811 | 對於C20 H22 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為379.1628;實測值為379.1639 | 1 H NMR (500 MHz, CDCl3 ) δ 7.72 (s, 1H), 7.43 (d,J = 37.9 Hz, 1H), 7.16 (qd,J = 9.3, 5.0 Hz, 1H), 6.94 - 6.82 (m, 1H), 6.56 (s, 1H), 5.38 (d,J = 1.4 Hz, 2H), 3.42 (d,J = 92.9 Hz, 2H), 3.01 (s, 3H), 2.53 (s, 3H), 2.22 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 119.16 (dt,J = 14.6, 6.5 Hz), - 136.70 (dd,J = 20.9, 8.6 Hz), - 141.34 - - 142.48 (m)。 | |
511 | (薄膜)2927, 1711, 1633, 1591, 1525, 1368, 1244, 1108, 861, 780, 714 | 對於C20 H21 F4 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為397.1534;實測值為397.1547 | 1 H NMR (500 MHz, CDCl3 ) δ 7.77 (s, 1H), 7.55 - 7.33 (m, 1H), 7.13 (dddd,J = 10.3, 8.1, 5.9, 2.5 Hz, 1H), 6.58 (s, 1H), 5.39 - 5.23 (m, 2H), 3.43 (d,J = 96.0 Hz, 2H), 3.02 (s, 3H), 2.54 (s, 3H), 2.24 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 138.48 - - 139.72 (m), - 142.38 - - 144.78 (m), - 155.44 (td,J = 19.9, 2.5 Hz), - 155.72 (tdd,J = 20.0, 7.9, 3.4 Hz)。 | |
512 | (薄膜)2926, 1710, 1632, 1592, 1518, 1244, 1107, 1083, 994, 837 | 對於C20 H21 F4 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為397.1534;實測值為397.1550 | 1 H NMR (500 MHz, CDCl3 ) δ 7.70 (s, 1H), 7.43 (d,J = 33.6 Hz, 1H), 6.83 (dddd,J = 10.1, 8.5, 5.8, 2.4 Hz, 1H), 6.56 (s, 1H), 5.33 (d,J = 1.4 Hz, 2H), 3.42 (d,J = 91.8 Hz, 2H), 3.01 (s, 3H), 2.52 (s, 3H), 2.22 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 117.31 (t,J = 10.5 Hz), - 130.34 - - 131.66 (m), - 134.36 (dd,J = 20.8, 6.7 Hz), - 164.73 (tdd,J = 21.2, 11.4, 5.9 Hz)。 | |
513 | (薄膜)2974, 1704, 1631, 1591, 1549, 1365, 1249, 1108, 782 | 對於C15 H23 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為263.1754;實測值為263.1763 | 1 H NMR (500 MHz, CDCl3 ) δ 7.75 (s, 1H), 7.43 (d,J = 34.9 Hz, 1H), 6.57 (s, 1H), 4.31 (q,J = 7.1 Hz, 2H), 3.41 (d,J = 85.5 Hz, 2H), 3.01 (s, 3H), 2.54 (s, 3H), 2.25 (s, 3H), 1.38 (t,J = 7.1 Hz, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 | |
514 | 對於C21 H27 N2 O3 計算的HRMS-ESI (m/z ) [M+H]+ 為355.2016;實測值為355.2019 | 1 H NMR (500 MHz, CDCl3 ) δ 7.64 (d,J = 8.4 Hz, 1H), 7.62 - 7.45 (m, 1H), 7.37 - 7.29 (m, 2H), 7.18 (d,J = 7.8 Hz, 2H), 6.71 (d,J = 8.3 Hz, 1H), 5.26 (s, 2H), 3.72 (s, 3H), 3.43 (d,J = 126.4 Hz, 2H), 3.04 (s, 3H), 2.53 (s, 3H), 2.35 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 | ||
515 | 對於C21 H24 F3 N2 O3 計算的HRMS-ESI (m/z ) [M+H]+ 為409.1734;實測值為409.1737 | 1 H NMR (500 MHz, CDCl3 ) δ 7.70 (s, 1H), 7.68 - 7.44 (m, 5H), 6.74 (d,J = 8.4 Hz, 1H), 5.35 (s, 2H), 3.73 (s, 3H), 3.44 (d,J = 124.9 Hz, 2H), 3.05 (s, 3H), 2.54 (s, 3H), 1.23 (t,J = 7.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 62.64。 | ||
516 | (薄膜)2972, 2925, 1708, 1632, 1591, 1547, 1486, 1369, 1245, 1106, 1085, 907 | 對於C20 H23 ClFN2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為377.1427;實測值為377.1437 | 1 H NMR (400 MHz, CDCl3 ) δ 7.79 (s, 1H), 7.55 - 7.40 (m, 2H), 7.32 - 7.25 (m, 1H), 7.03 (t,J = 9.0 Hz, 1H), 6.58 (s, 1H), 5.33 (d,J = 1.3 Hz, 2H), 3.76 - 3.22 (m, 2H), 3.02 (s, 3H), 2.55 (s, 3H), 2.24 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 120.52。 | |
517 | (薄膜)2970, 2923, 1707, 1631, 1591, 1547, 1501, 1368, 1244, 1106, 1085, 814 | 對於C21 H26 FN2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為357.1973;實測值為357.1984 | 1 H NMR (400 MHz, CDCl3 ) δ 7.78 (s, 1H), 7.49 (s, 1H), 7.25 - 7.23 (m, 1H), 7.10 (ddd,J = 7.8, 5.1, 2.3 Hz, 1H), 6.97 (dd,J = 9.8, 8.4 Hz, 1H), 6.57 (s, 1H), 5.44 - 5.23 (m, 2H), 3.62 - 3.18 (m, 2H), 3.01 (s, 3H), 2.54 (s, 3H), 2.32 (d,J = 1.1 Hz, 3H), 2.23 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 123.34。 | |
518 | 對於C20 H22 F3 N2 O3 計算的HRMS-ESI (m/z ) [M+H]+ 為395.1577;實測值為395.1589 | 1 H NMR (400 MHz, CDCl3 ) δ 7.63 (d,J = 8.4 Hz, 1H), 7.52 - 7.33 (m, 1H), 6.78 - 6.63 (m, 2H), 6.54 (d,J = 8.4 Hz, 1H), 5.35 (s, 2H), 3.74 (s, 3H), 3.62 - 3.19 (m, 2H), 3.02 (s, 3H), 2.22 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 106.49 (t,J = 6.9 Hz), -110.80 (d,J = 6.9 Hz)。 | ||
519 | 對於C20 H22 F3 N2 O3 計算的HRMS-ESI (m/z ) [M+H]+ 為395.1577;實測值為395.1587 | 1 H NMR (400 MHz, CDCl3 ) δ 7.66 - 7.47 (m, 1H), 7.43 (s, 1H), 6.77 - 6.66 (m, 2H), 6.62 (s, 1H), 5.35 (d,J = 1.3 Hz, 2H), 3.82 (s, 3H), 3.64 - 3.24 (m, 2H), 3.10 - 2.97 (m, 3H), 2.48 (s, 3H), 1.22 (t,J = 7.0 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 106.44 (t,J = 6.9 Hz), -110.84 (d,J = 6.9 Hz)。 | ||
520 | 對於C20 H19 F6 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為433.1345;實測值為433.1357 | 1 H NMR (400 MHz, CDCl3 ) δ 7.47 - 7.29 (m, 1H), 7.26 - 7.23 (m, 1H), 6.85 (d,J = 8.2 Hz, 1H), 6.69 (dd,J = 8.8, 7.3 Hz, 2H), 5.33 (s, 2H), 3.64 - 3.24 (m, 2H), 3.02 (s, 3H), 2.48 - 2.31 (m, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 56.14, - 105.99 (t,J = 6.8 Hz), - 110.89 (d,J = 7.4 Hz)。 | ||
521 | 對於C20 H19 F6 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為433.1345;實測值為433.1358 | 1 H NMR (400 MHz, CDCl3 ) δ 7.64 (s, 1H), 7.56 - 7.34 (m, 1H), 7.04 (s, 1H), 6.77 - 6.60 (m, 2H), 5.36 (s, 2H), 3.72 - 3.22 (m, 2H), 3.03 (s, 3H), 2.29 (s, 3H), 1.27 - 1.20 (m, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 59.13, - 106.07 (t,J = 6.9 Hz), - 110.85 (d,J = 7.0 Hz)。 | ||
522 | 對於C20 H19 F6 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為433.1345;實測值為433.1359 | 1 H NMR (400 MHz, CDCl3 ) δ 7.72 (d,J = 8.5 Hz, 1H), 7.34 (s, 1H), 6.78 - 6.66 (m, 2H), 6.64 (d,J = 8.1 Hz, 1H), 5.34 (s, 2H), 3.57 - 3.22 (m, 2H), 3.00 (s, 3H), 2.60 (q,J = 3.2 Hz, 3H), 1.24 - 1.12 (m, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 51.81, -105.97 (t,J = 7.0 Hz), -110.96 (d,J = 7.1 Hz)。 | ||
523 | 對於C20 H19 F6 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為433.1345;實測值為433.1357 | 1 H NMR (400 MHz, CDCl3 ) δ 8.13 (s, 1H), 7.59 - 7.40 (m, 1H), 6.79 - 6.65 (m, 3H), 5.34 (d,J = 1.3 Hz, 2H), 3.56 - 3.26 (m, 2H), 3.03 (s, 3H), 2.58 (s, 3H), 1.28 - 1.11 (m, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 60.96, - 106.17 (t,J = 6.5 Hz), - 110.92 (d,J = 6.9 Hz)。 | ||
524 | 對於C20 H24 FN2 O3 計算的HRMS-ESI (m/z ) [M+H]+ 為359.1765;實測值為359.1780 | 1 H NMR (500 MHz, CDCl3 ) δ 7.73 - 7.52 (m, 2H), 7.48 (td,J = 7.5, 1.8 Hz, 1H), 7.32 (tdd,J = 7.5, 5.3, 1.8 Hz, 1H), 7.15 (td,J = 7.5, 1.2 Hz, 1H), 7.09 (ddd,J = 9.6, 8.2, 1.2 Hz, 1H), 6.72 (d,J = 8.4 Hz, 1H), 5.37 (d,J = 1.1 Hz, 2H), 3.72 (s, 3H), 3.66 - 3.40 (m, 1H), 3.31 (s, 1H), 3.05 (s, 3H), 2.53 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H) 19 F NMR (471 MHz, CDCl3 ) δ - 117.92 | ||
525 | 對於C20 H22 F3 N2 O3 計算的HRMS-ESI (m/z ) [M+H]+ 為395.1577;實測值為395.1582 | 1 H NMR (500 MHz, CDCl3 ) δ 7.58 (d,J = 8.4 Hz, 2H), 6.70 (ddd,J = 10.6, 6.4, 4.3 Hz, 3H), 5.33 (d,J = 1.3 Hz, 2H), 3.71 (s, 3H), 3.66 - 3.48 (m, 1H), 3.31 (s, 1H), 3.04 (s, 3H), 2.51 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 106.47, - 110.89 (t,J = 7.2 Hz)。 | ||
526 | 對於C20 H23 ClFN2 O3 計算的HRMS-ESI (m/z ) [M+H]+ 為393.1376;實測值為393.1378 | 1 H NMR (500 MHz, CDCl3 ) δ 7.84 - 7.43 (m, 2H), 7.42 (t,J = 8.1 Hz, 1H), 7.22 - 6.88 (m, 2H), 6.72 (d,J = 8.4 Hz, 1H), 5.32 (d,J = 1.2 Hz, 2H), 3.72 (s, 3H), 3.45 (d,J = 129.0 Hz, 2H), 3.05 (s, 3H), 2.52 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 115.15 (t,J = 8.5 Hz)。 | ||
527 | 對於C20 H23 ClFN2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為377.1427;實測值為377.1435 | 1 H NMR (400 MHz, CDCl3 ) δ 7.78 (s, 1H), 7.57 - 7.32 (m, 3H), 7.09 (td,J = 7.9, 1.2 Hz, 1H), 6.57 (s, 1H), 5.38 (d,J = 1.4 Hz, 2H), 3.70 - 3.17 (m, 2H), 3.01 (s, 3H), 2.54 (s, 3H), 2.24 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 119.76。 | ||
528 | ESIMSm/z 357 [(M+H)+ ] | 1 H NMR (400 MHz, CDCl3 ) δ 7.48 (td,J = 7.5, 1.9 Hz, 1H), 7.37 - 7.29 (m, 2H), 7.14 (td,J = 7.5, 1.3 Hz, 1H), 7.08 (ddd,J = 9.6, 8.3, 1.2 Hz, 1H), 6.43 (s, 1H), 5.40 (d,J = 1.3 Hz, 2H), 3.56 - 3.29 (m, 2H), 2.99 (s, 3H), 2.22 (s, 3H), 2.18 (s, 3H), 2.17 (s, 3H), 1.20 (t,J = 7.1 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 117.60。 | ||
529 | ESIMSm/z 383 [(M+H)+ ] | 1 H NMR (400 MHz, CDCl3 ) δ 7.81 (d,J = 8.3 Hz, 1H), 7.64 - 7.44 (m, 2H), 7.38 - 7.28 (m, 2H), 7.15 (td,J = 7.5, 1.2 Hz, 1H), 7.11 - 7.01 (m, 2H), 5.41 (d,J = 1.2 Hz, 2H), 3.64 - 3.25 (m, 2H), 3.04 (s, 3H), 1.24 (q,J = 8.0, 7.5 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 59.52, - 117.89。 | ||
530 | ESIMSm/z 383 [(M+H)+ ] | 1 H NMR (400 MHz, CDCl3 ) δ 8.27 (d,J = 2.1 Hz, 1H), 8.07 (dd,J = 8.4, 2.1 Hz, 1H), 7.59 - 7.44 (m, 2H), 7.34 (tdd,J = 7.4, 5.2, 1.8 Hz, 1H), 7.16 (td,J = 7.5, 1.2 Hz, 1H), 7.10 (ddd,J = 9.7, 8.2, 1.2 Hz, 1H), 6.90 (t,J = 8.0 Hz, 1H), 5.42 (d,J = 1.2 Hz, 2H), 3.59 - 3.30 (m, 2H), 3.05 (d,J = 2.2 Hz, 3H), 1.25 (t,J = 7.1 Hz, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 61.41, - 117.87。 | ||
531 | 對於C20 H23 F2 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為361.1722;實測值為361.1735 | 1 H NMR (600 MHz, CDCl3 ) δ 7.68 (d,J = 8.3 Hz, 1H), 7.39 (d,J = 58.0 Hz, 1H), 7.23 (ddd,J = 10.5, 7.1, 2.9 Hz, 1H), 7.16 - 7.03 (m, 2H), 6.62 (d,J = 8.4 Hz, 1H), 5.20 (s, 2H), 3.38 (d,J = 147.5 Hz, 2H), 2.99 (s, 3H), 2.51 (s, 3H), 2.28 (s, 3H), 1.17 (t,J = 7.1 Hz, 3H)。 19 F NMR (564 MHz, CDCl3 ) δ - 137.49 (dd,J = 19.3, 11.2 Hz), - 138.85 (dt,J = 22.0, 6.9 Hz)。 | ||
532 | 對於C20 H23 F2 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為361.1722;實測值為361.1736 | 1 H NMR (600 MHz, CDCl3 ) δ 7.72 (d,J = 8.4 Hz, 1H), 7.39 (d,J = 57.3 Hz, 1H), 6.92 (h,J = 4.6 Hz, 2H), 6.70 (tt,J = 8.9, 2.4 Hz, 1H), 6.62 (d,J = 8.4 Hz, 1H), 5.22 (s, 2H), 3.37 (d,J = 151.7 Hz, 2H), 2.97 (d,J = 22.1 Hz, 3H), 2.53 (s, 3H), 2.28 (s, 3H), 1.17 (t,J = 7.2 Hz, 3H)。 19 F NMR (564 MHz, CDCl3 ) δ - 107.07 - - 114.05 (m)。 | ||
533 | 對於C20 H22 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為379.1628;實測值為379.1639 | 1 H NMR (600 MHz, CDCl3 ) δ 7.69 (d,J = 8.4 Hz, 1H), 7.55 - 7.26 (m, 1H), 6.96 (ddt,J = 7.7, 4.7, 2.3 Hz, 1H), 6.84 (dtt,J = 9.5, 5.9, 3.1 Hz, 1H), 6.61 (d,J = 8.3 Hz, 1H), 5.32 (s, 2H), 3.39 (d,J = 144.1 Hz, 2H), 3.00 (s, 3H), 2.52 (s, 3H), 2.28 (s, 3H), 1.19 (t,J = 7.1 Hz, 3H)。 19 F NMR (564 MHz, CDCl3 ) δ - 111.63 - - 121.11 (m), - 133.52 (dd,J = 20.5, 10.1 Hz), - 141.90 - - 155.42 (m)。 | ||
534 | 對於C20 H22 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為379.1628;實測值為379.1641 | 1 H NMR (600 MHz, CDCl3 ) δ 7.62 (d,J = 8.4 Hz, 1H), 7.38 (d,J = 46.3 Hz, 1H), 7.10 (qd,J = 9.2, 4.9 Hz, 1H), 6.87 - 6.77 (m, 1H), 6.58 (d,J = 8.4 Hz, 1H), 5.37 (s, 2H), 3.38 (d,J = 143.7 Hz, 2H), 2.98 (s, 3H), 2.50 (s, 3H), 2.26 (s, 3H), 1.17 (t,J = 7.2 Hz, 3H)。 19 F NMR (564 MHz, CDCl3 ) δ - 119.24 (dt,J = 14.1, 6.3 Hz), - 136.98 (dd,J = 20.6, 9.0 Hz), - 139.18 - - 145.28 (m)。 | ||
535 | 對於C20 H21 F4 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為397.1534;實測值為397.1544 | 1 H NMR (600 MHz, CDCl3 ) δ 7.66 (d,J = 8.3 Hz, 1H), 7.41 (d,J = 56.1 Hz, 1H), 7.10 (dddd,J = 10.3, 8.1, 5.8, 2.4 Hz, 1H), 6.61 (d,J = 8.4 Hz, 1H), 5.28 (s, 2H), 3.41 (d,J = 137.7 Hz, 2H), 3.01 (s, 3H), 2.50 (s, 3H), 2.27 (s, 3H), 1.21 (t,J = 7.1 Hz, 3H)。 19 F NMR (564 MHz, CDCl3 ) δ - 139.15 (dt,J = 22.0, 11.7 Hz), - 143.09 (t,J = 16.7 Hz), - 155.72 (t,J = 19.6 Hz), -156.00 (td,J = 20.4, 8.3 Hz)。 | ||
536 | 對於C20 H21 F4 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為397.1534;實測值為397.1546 | 1 H NMR (600 MHz, CDCl3 ) δ 7.60 (d,J = 8.4 Hz, 1H), 7.51 - 7.30 (m, 1H), 6.84 - 6.71 (m, 1H), 6.57 (d,J = 8.4 Hz, 1H), 5.31 (s, 2H), 3.39 (d,J = 141.6 Hz, 2H), 2.99 (s, 3H), 2.49 (s, 3H), 2.26 (s, 3H), 1.18 (t,J = 7.2 Hz, 3H)。 19 F NMR (564 MHz, CDCl3 ) δ - 117.38 (t,J = 10.5 Hz), - 131.08 (dt,J = 18.4, 8.6 Hz), - 134.71 (dd,J = 20.7, 6.3 Hz), - 165.04 (dd,J = 12.8, 7.3 Hz)。 | ||
537 | 對於C18 H25 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為359.1941;實測值為359.1956 | |||
538 | 對於C19 H25 N4 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為341.1972;實測值為341.1976 | |||
539 | 對於C18 H23 N4 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為327.1816;實測值為327.1820 | |||
540 | 對於C15 H20 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為317.1471;實測值為317.1487 | 1 H NMR (500 MHz, CDCl3 ) δ 7.72 (d,J = 8.4 Hz, 1H), 7.41 (d,J = 39.9 Hz, 1H), 6.64 (d,J = 8.4 Hz, 1H), 4.63 (q,J = 8.6 Hz, 2H), 3.41 (d,J = 113.7 Hz, 2H), 3.01 (s, 3H), 2.52 (s, 3H), 2.29 (s, 3H), 1.21 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 73.54 (d,J = 8.7 Hz)。 | ||
541 | 對於C18 H23 N4 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為327.1816;實測值為327.1829 | 1 H NMR (500 MHz, CDCl3 ) δ 8.77 (d,J = 1.5 Hz, 1H), 8.62 - 8.44 (m, 2H), 7.76 (d,J = 8.4 Hz, 1H), 7.58 - 7.30 (m, 1H), 6.66 (d,J = 8.4 Hz, 1H), 5.46 (s, 2H), 3.44 (d,J = 109.0 Hz, 2H), 3.04 (s, 3H), 2.54 (s, 3H), 2.29 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 | ||
542 | 對於C18 H23 N4 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為327.1816;實測值為327.1826 | 1 H NMR (500 MHz, CDCl3 ) δ 9.19 (s, 1H), 8.73 (d,J = 5.2 Hz, 1H), 7.80 (d,J = 8.3 Hz, 1H), 7.59 - 7.33 (m, 2H), 6.71 (d,J = 8.5 Hz, 1H), 5.40 (s, 2H), 3.75 - 3.19 (m, 2H), 3.07 (s, 3H), 2.55 (s, 3H), 2.31 (s, 3H), 1.24 (t,J = 7.1 Hz, 3H)。 | ||
543 | 對於C21 H23 F4 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為411.1690;實測值為411.1701 | 1 H NMR (500 MHz, CDCl3 ) δ 7.61 (d,J = 8.3 Hz, 1H), 7.42 (s, 1H), 6.58 (d,J = 8.4 Hz, 1H), 5.38 (d,J = 1.9 Hz, 2H), 3.41 (d,J = 105.2 Hz, 2H), 3.01 (s, 3H), 2.50 (s, 3H), 2.31 - 2.22 (m, 6H), 1.21 (t,J = 7.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 143.78 (dd,J = 21.9, 12.9 Hz), - 144.37 (dd,J = 21.7, 13.1 Hz)。 | ||
544 | 對於C20 H20 F5 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為415.1439;實測值為415.1452 | 1 H NMR (500 MHz, CDCl3 ) δ 7.60 (d,J = 8.3 Hz, 1H), 7.43 (s, 1H), 6.59 (d,J = 8.4 Hz, 1H), 5.36 (d,J = 1.7 Hz, 2H), 3.42 (d,J = 105.5 Hz, 2H), 3.01 (s, 3H), 2.50 (s, 3H), 2.27 (s, 3H), 1.21 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 141.78 (dd,J = 21.6, 8.3 Hz), - 153.14 (t,J = 20.7 Hz), - 161.81 (td,J = 22.5, 21.8, 8.0 Hz)。 | ||
545 | 對於C20 H22 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為379.1628;實測值為379.1643 | 1 H NMR (500 MHz, CDCl3 ) δ 7.68 (d,J = 8.3 Hz, 1H), 7.58 - 7.26 (m, 1H), 7.12 - 6.97 (m, 2H), 6.63 (d,J = 8.4 Hz, 1H), 5.20 (s, 2H), 3.42 (d,J = 108.5 Hz, 2H), 3.02 (s, 3H), 2.52 (s, 3H), 2.28 (s, 3H), 1.21 (t,J = 7.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 133.97 (d,J = 28.0 Hz), -159.36 - - 163.92 (m)。 | ||
546 | 對於C20 H22 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為379.1628;實測值為379.1639 | 1 H NMR (500 MHz, CDCl3 ) δ 7.65 (d,J = 8.4 Hz, 1H), 7.43 (s, 1H), 7.24 - 7.16 (m, 1H), 6.95 (tdd,J = 9.2, 6.8, 2.1 Hz, 1H), 6.61 (d,J = 8.4 Hz, 1H), 5.32 (s, 2H), 3.41 (d,J = 106.2 Hz, 2H), 3.01 (s, 3H), 2.50 (s, 3H), 2.27 (s, 3H), 1.21 (t,J = 7.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 134.15 (dt,J = 21.2, 7.5 Hz), -137.66 - - 138.58 (m), -160.43 (td,J = 20.6, 7.1 Hz)。 | ||
547 | 對於C20 H21 F4 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為397.1534;實測值為397.1549 | 1 H NMR (500 MHz, CDCl3 ) δ 7.62 (d,J = 8.3 Hz, 1H), 7.42 (s, 1H), 7.07 (tt,J = 9.8, 7.3 Hz, 1H), 6.59 (d,J = 8.4 Hz, 1H), 5.40 (t,J = 1.5 Hz, 2H), 3.41 (d,J = 107.8 Hz, 2H), 3.01 (s, 3H), 2.50 (s, 3H), 2.27 (s, 3H), 1.21 (t,J = 7.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 138.91 (ddd,J = 22.5, 13.7, 8.8 Hz), - 142.61 (ddd,J = 21.9, 13.5, 7.5 Hz)。 | ||
548 | 對於C20 H29 F2 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為367.2192;實測值為367.2205 | 1 H NMR (500 MHz, CDCl3 ) δ 7.63 (d,J = 8.3 Hz, 1H), 7.54 - 7.28 (m, 1H), 6.63 (d,J = 8.3 Hz, 1H), 4.13 (d,J = 6.3 Hz, 2H), 3.77 - 3.19 (m, 2H), 3.02 (s, 3H), 2.51 (s, 3H), 2.28 (s, 3H), 2.12 (ddq,J = 10.5, 7.1, 3.3 Hz, 2H), 1.98 - 1.59 (m, 5H), 1.52 - 1.33 (m, 2H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 91.61 (d,J = 235.8 Hz), - 102.02 (d,J = 235.8 Hz)。 | ||
549 | 對於C18 H25 F2 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為339.1879;實測值為339.1893 | 1 H NMR (500 MHz, CDCl3 ) δ 7.63 (d,J = 8.3 Hz, 1H), 7.45 (d,J = 6.9 Hz, 1H), 6.64 (d,J = 8.3 Hz, 1H), 4.30 (d,J = 6.3 Hz, 2H), 3.42 (d,J = 107.5 Hz, 2H), 3.02 (s, 3H), 2.71 (ddt,J = 14.0, 11.0, 8.2 Hz, 2H), 2.59 (dddd,J = 11.2, 8.9, 5.0, 2.3 Hz, 1H), 2.53 - 2.38 (m, 5H), 2.28 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 83.30 (ddd,J = 194.1, 13.4, 7.4 Hz), - 93.99 (dt,J = 193.3, 14.2 Hz)。 | ||
550 | 對於C17 H23 F2 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為325.1722;實測值為325.1734 | 1 H NMR (500 MHz, CDCl3 ) δ 7.66 (d,J = 8.3 Hz, 1H), 7.45 (s, 1H), 6.63 (d,J = 8.4 Hz, 1H), 5.08 (dtdd,J = 13.3, 7.7, 5.6, 3.7 Hz, 1H), 3.70 - 3.19 (m, 2H), 3.10 (ddt,J = 15.6, 11.7, 7.1 Hz, 2H), 3.02 (s, 3H), 2.77 (tdd,J = 15.2, 13.0, 5.5 Hz, 2H), 2.51 (s, 3H), 2.28 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 84.79 (ddd,J = 199.4, 13.8, 6.9 Hz), -94.24 - - 104.28 (m)。 | ||
551 | 對於C16 H20 F5 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為367.1439;實測值為367.1453 | 1 H NMR (500 MHz, CDCl3 ) δ 7.72 (d,J = 8.4 Hz, 1H), 7.42 (d,J = 39.6 Hz, 1H), 6.64 (d,J = 8.4 Hz, 1H), 4.70 (t,J = 13.0 Hz, 2H), 3.42 (d,J = 112.9 Hz, 2H), 3.02 (s, 3H), 2.53 (s, 3H), 2.29 (s, 3H), 1.21 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 83.78, - 123.16。 | ||
552 | 對於C17 H22 F5 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為381.1596;實測值為381.1610 | 1 H NMR (500 MHz, CDCl3 ) δ 7.65 (d,J = 8.3 Hz, 1H), 7.44 (s, 1H), 6.62 (d,J = 8.3 Hz, 1H), 4.53 (t,J = 6.6 Hz, 2H), 3.74 - 3.18 (m, 2H), 3.01 (s, 3H), 2.64 - 2.44 (m, 5H), 2.28 (s, 3H), 1.21 (t,J = 7.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 85.71, - 117.40。 | ||
553 | 對於C18 H24 BrF4 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為455.0952;實測值為455.0962 | 1 H NMR (500 MHz, CDCl3 ) δ 7.62 (d,J = 8.3 Hz, 1H), 7.44 (s, 1H), 6.63 (d,J = 8.3 Hz, 1H), 4.33 (t,J = 6.2 Hz, 2H), 3.42 (d,J = 102.4 Hz, 2H), 3.02 (s, 3H), 2.51 (s, 3H), 2.34 - 2.19 (m, 5H), 2.08 (dt,J = 10.0, 6.1 Hz, 2H), 1.22 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 65.60, - 111.99。 | ||
554 | 對於C18 H24 BrClF3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為473.0635;實測值為473.0648 | 1 H NMR (500 MHz, CDCl3 ) δ 7.62 (d,J = 8.3 Hz, 1H), 7.44 (s, 1H), 6.63 (d,J = 8.3 Hz, 1H), 4.34 (hept,J = 5.6 Hz, 2H), 3.42 (d,J = 104.4 Hz, 2H), 3.02 (s, 3H), 2.51 (s, 4H), 2.45 - 1.99 (m, 6H), 1.21 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 60.24 - - 61.99 (m), - 114.78 - - 121.09 (m)。 | ||
555 | 對於C18 H27 F2 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為341.2035;實測值為341.2049 | 1 H NMR (500 MHz, CDCl3 ) δ 7.62 (d,J = 8.3 Hz, 1H), 7.43 (s, 1H), 6.62 (d,J = 8.3 Hz, 1H), 4.29 (t,J = 6.1 Hz, 2H), 3.41 (d,J = 102.7 Hz, 2H), 3.01 (s, 3H), 2.51 (s, 3H), 2.28 (s, 3H), 2.13 - 1.89 (m, 4H), 1.62 (t,J = 18.3 Hz, 3H), 1.21 (t,J = 7.1 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 91.13 (q,J = 16.7, 16.0 Hz)。 | ||
556 | 對於C17 H25 F2 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為327.1879;實測值為327.1892 | 1 H NMR (500 MHz, CDCl3 ) δ 7.63 (d,J = 8.3 Hz, 1H), 7.54 - 7.28 (m, 1H), 6.62 (d,J = 8.3 Hz, 1H), 4.43 (t,J = 6.6 Hz, 2H), 3.41 (d,J = 105.0 Hz, 2H), 3.01 (s, 3H), 2.51 (s, 3H), 2.34 (tt,J = 15.5, 6.7 Hz, 2H), 2.28 (s, 3H), 1.68 (t,J = 18.6 Hz, 3H), 1.21 (t,J = 7.1 Hz, 3H) 19 F NMR (471 MHz, CDCl3 ) δ - 89.32 (d,J = 17.7 Hz)。 | ||
557 | 對於C16 H22 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為331.1628;實測值為331.1640 | 1 H NMR (500 MHz, CDCl3 ) δ 7.65 (d,J = 8.3 Hz, 1H), 7.45 (d,J = 11.7 Hz, 1H), 6.62 (d,J = 8.4 Hz, 1H), 4.48 (t,J = 6.4 Hz, 2H), 3.75 - 3.18 (m, 2H), 3.02 (s, 3H), 2.58 (qt,J = 10.7, 6.4 Hz, 2H), 2.51 (s, 3H), 2.28 (s, 3H), 1.22 (t,J = 7.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 64.85。 | ||
558 | 對於C18 H23 N4 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為327.1816;實測值為327.1828 | 1 H NMR (500 MHz, CDCl3 ) δ 8.73 (d,J = 4.9 Hz, 2H), 7.82 (d,J = 8.3 Hz, 1H), 7.46 (s, 1H), 7.20 (t,J = 4.9 Hz, 1H), 6.67 (d,J = 8.3 Hz, 1H), 5.51 (s, 2H), 3.44 (d,J = 107.5 Hz, 2H), 3.04 (s, 3H), 2.54 (s, 3H), 2.29 (s, 3H), 1.22 (t,J = 7.1 Hz, 3H)。 | ||
559 | 對於C19 H23 FN3 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為344.1769;實測值為344.1780 | 1 H NMR (500 MHz, CDCl3 ) δ 8.46 - 8.37 (m, 1H), 7.69 (d,J = 8.3 Hz, 1H), 7.42 (ddd,J = 9.7, 8.4, 1.3 Hz, 2H), 7.31 - 7.27 (m, 1H), 6.59 (d,J = 8.4 Hz, 1H), 5.48 (d,J = 2.0 Hz, 2H), 3.40 (d,J = 101.2 Hz, 2H), 3.00 (s, 3H), 2.51 (s, 3H), 2.26 (s, 3H), 1.20 (t,J = 7.2 Hz, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 124.50 (d,J = 8.8 Hz)。 | ||
560 | 158-165 | 對於C21 H24 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為393.1784,實測值為393.1800 | 1 H NMR (500 MHz, CDCl3 ) δ 11.28 - 11.05 (m, 1H), 8.30 - 8.10 (m, 1H), 7.76 - 7.72 (m, 1H), 7.68 (s, 1H), 7.65 - 7.57 (m, 2H), 7.55 - 7.49 (m, 1H), 7.46 - 7.39 (m, 1H), 5.35 (s, 2H), 3.99 (q,J = 7.2 Hz, 0.5H), 3.75 (q,J = 7.1 Hz, 1.5H), 3.50 (s, 2.25H), 3.40 (s, 0.75H), 2.50 - 2.44 (m, 6H), 1.34 - 1.27 (m, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 62.61 | |
561 | 114-118 | 對於C21 H24 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為393.1784,實測值為393.1799 | 1 H NMR (500 MHz, CDCl3 ) δ 10.53 (s, 1H), 7.82 - 7.66 (m, 3H), 7.65 - 7.58 (m, 2H), 7.55 - 7.49 (m, 1H), 7.03 (s, 1H), 5.36 (s, 2H), 3.81 (q,J = 7.5 Hz, 0.5H), 3.58 (q,J = 7.2 Hz, 1.5H), 3.37 (s, 2H), 3.27 (s, 1H), 2.50 (s, 3H), 2.34 (s, 3H), 1.37 - 1.27 (m, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 62.66, - 75.55 | |
562 | 對於C21 H24 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為393.1784,實測值為393.1798 | 1 H NMR (500 MHz, CDCl3 ) δ 11.08 (d,J = 12.9 Hz, 1H), 8.19 - 8.00 (m, 1H), 7.69 (s, 1H), 7.65 - 7.58 (m, 3H), 7.55 - 7.49 (m, 1H), 7.45 - 7.39 (m, 2H), 7.10 - 7.06 (m, 1H), 6.90 (m, 2H), 5.35 (s, 2H), 3.70 (q,J = 7.2 Hz, 0.5H), 3.62 (q,J = 7.1 Hz, 1.5H), 3.27 (s, 3H), 2.40 - 2.36 (m, 3H), 2.23 - 2.13 (m, 6H), 1.24 - 1.16 (m, 3H)。 19 F NMR (471 MHz, CDCl3 ) δ - 62.61 | ||
563 | 172-178 | 對於C20 H22 F3 N2 O2 計算的HRMS-ESI (m/z ) [M+H]+ 為379.1628,實測值為379.1640 | 1 H NMR (400 MHz, CDCl3 ) δ 13.54 - 13.31 (m, 1H), 7.76 (s, 1H), 7.61 - 7.43 (m, 1H), 7.15 - 7.08 (m, 1H), 6.79 - 6.67 (m, 2H), 5.36 (s, 2H), 4.24 (q,J = 7.1 Hz, 0.6H), 3.70 (s, 2H), 3.61 (q,J = 7.2 Hz, 1.4H), 3.35 (s, 1H), 2.54 - 2.48 (m, 6H), 1.49 - 1.37 (m, 3H)。 19 F NMR (376 MHz, CDCl3 ) δ - 105.75, - 110.91 |
真菌病原體評級表 | |
% 疾病控制 | 評級 |
> 85% | A |
50 - 85% | B |
20 - < 50% | C |
< 20% | D |
未測試 | E |
化合物編號 | % 疾病控制評級 | ||||||
CD-1DP | CD-3DC | ||||||
COCHSA | PHAKPA | PUCCRT | RHYNSE | SEPTTR | PHAKPA | SEPTTR | |
200 ppm | 200 ppm | 200 ppm | 200 ppm | 200 ppm | 200 ppm | 200 ppm | |
1 | E | B | A | E | D | A | D |
2 | D | D | D | E | D | D | D |
3 | D | A | A | E | C | A | B |
4 | C | A | A | E | D | A | D |
5 | D | E | D | E | C | E | D |
6 | C | C | A | E | D | A | D |
7 | B | B | A | E | C | A | C |
8 | B | A | A | E | A | A | D |
9 | A | A | A | A | B | A | B |
10 | C | A | A | A | B | A | C |
11 | A | B | A | B | A | A | C |
12 | A | C | B | A | A | B | B |
13 | D | E | A | E | C | E | C |
14 | D | D | C | E | D | B | D |
15 | D | D | D | E | C | B | D |
16 | B | A | A | A | A | A | B |
17 | C | A | A | E | D | A | D |
18 | A | A | A | A | B | A | A |
19 | C | A | A | E | D | A | D |
20 | B | A | A | E | C | A | D |
21 | B | A | A | A | C | A | B |
22 | B | A | A | C | C | A | C |
23 | A | A | A | E | C | A | D |
24 | B | A | A | E | D | A | D |
25 | A | A | A | A | B | A | C |
26 | A | A | A | A | A | A | B |
27 | A | A | A | A | A | A | B |
28 | A | A | A | A | A | A | B |
29 | A | A | A | A | B | A | B |
30 | A | A | A | A | A | A | A |
31 | A | A | A | E | C | A | C |
32 | A | A | A | B | B | A | C |
33 | A | A | A | A | A | A | B |
34 | B | C | A | E | D | B | D |
35 | D | A | A | E | C | A | D |
36 | D | A | A | A | A | A | D |
37 | A | A | A | E | A | A | B |
38 | B | A | A | E | A | A | A |
39 | A | C | D | E | C | C | B |
40 | A | A | A | E | A | A | A |
41 | A | A | A | E | A | A | A |
42 | A | A | A | E | A | A | A |
43 | A | A | A | E | B | A | C |
44 | A | A | A | E | A | A | A |
45 | A | A | A | E | A | A | A |
46 | B | A | A | E | A | A | B |
47 | A | A | A | E | A | A | B |
48 | A | A | A | E | A | A | A |
49 | B | A | A | E | A | A | B |
50 | B | B | A | E | C | A | B |
51 | A | A | A | E | A | A | A |
52 | A | A | A | E | A | A | A |
53 | E | A | E | E | E | A | E |
54 | E | A | E | E | E | A | E |
55 | C | A | A | E | C | A | B |
56 | D | B | A | E | D | A | D |
57 | E | A | A | A | A | A | C |
58 | D | A | A | E | B | A | D |
59 | D | D | D | E | D | D | D |
60 | D | D | D | E | D | C | C |
61 | D | A | A | E | C | A | C |
62 | A | A | A | E | B | A | B |
63 | D | D | D | E | D | C | D |
64 | B | C | A | E | B | B | A |
65 | A | A | A | A | A | A | A |
66 | B | B | A | E | B | A | B |
67 | D | D | D | E | D | D | D |
68 | A | A | D | A | B | A | A |
69 | A | A | A | A | A | A | B |
70 | D | D | D | E | C | D | D |
71 | D | D | D | E | D | C | D |
72 | D | D | D | E | D | C | D |
73 | A | A | A | E | B | B | D |
74 | D | D | D | E | D | D | D |
75 | D | D | D | E | D | D | D |
76 | D | D | D | E | D | D | D |
77 | D | D | D | E | D | D | C |
78 | D | D | D | E | D | D | D |
79 | C | A | B | E | B | A | B |
80 | D | C | C | E | B | C | C |
81 | D | C | D | E | D | D | C |
82 | C | B | C | E | B | C | C |
83 | B | B | A | E | B | B | A |
84 | D | D | D | E | D | D | D |
85 | D | D | D | E | D | D | D |
86 | D | D | D | E | D | D | C |
87 | D | D | D | E | D | D | D |
88 | A | C | D | E | D | D | D |
89 | D | C | D | E | D | D | C |
90 | C | D | D | E | C | D | D |
91 | B | A | C | E | B | A | A |
92 | D | A | B | E | D | A | D |
93 | D | B | C | E | D | C | D |
94 | D | C | D | E | C | D | D |
95 | D | C | D | E | D | D | C |
96 | D | C | B | E | D | A | D |
97 | D | A | A | C | D | A | B |
98 | D | B | A | E | A | A | B |
99 | D | C | D | E | A | D | D |
100 | D | C | B | E | A | C | D |
101 | D | C | C | E | B | D | D |
102 | D | C | D | E | D | D | C |
103 | D | A | B | E | B | A | D |
104 | D | C | C | E | D | D | D |
105 | D | C | A | E | D | C | C |
106 | D | A | A | E | B | C | B |
107 | D | A | A | E | A | A | B |
108 | E | D | E | E | E | D | E |
109 | D | C | D | E | D | D | B |
110 | D | A | A | E | B | A | A |
111 | D | A | A | E | A | A | C |
112 | B | A | A | A | A | A | B |
113 | D | A | D | D | D | A | C |
114 | D | A | A | D | D | A | B |
115 | C | A | A | C | D | B | D |
116 | B | A | A | C | D | A | B |
117 | C | A | A | A | A | A | A |
118 | D | A | B | D | D | B | B |
119 | D | A | A | D | D | A | A |
120 | D | A | A | C | D | A | C |
121 | C | A | A | B | A | A | B |
122 | D | A | A | C | D | A | D |
123 | B | A | A | A | B | A | C |
124 | C | A | A | B | A | A | D |
125 | A | A | A | A | A | A | B |
126 | D | A | A | D | D | A | A |
127 | C | A | A | A | A | A | A |
128 | C | A | A | B | A | A | B |
129 | B | A | A | A | A | A | A |
130 | C | C | A | A | A | B | C |
131 | D | C | A | B | A | A | D |
132 | D | D | B | A | A | C | D |
133 | D | C | A | D | B | C | D |
134 | D | D | B | D | A | D | D |
135 | D | D | C | D | D | B | D |
136 | C | D | A | B | B | D | D |
137 | C | D | D | D | B | D | D |
138 | D | D | A | D | D | D | D |
139 | D | D | A | A | C | D | B |
140 | D | D | D | D | B | D | D |
141 | D | D | D | D | D | D | D |
142 | A | A | A | A | A | A | D |
143 | A | A | A | A | A | A | D |
144 | A | A | A | E | A | A | D |
145 | A | A | A | E | A | A | D |
146 | C | B | A | E | B | B | D |
147 | A | A | A | E | A | A | D |
148 | A | A | A | E | A | A | D |
149 | A | B | A | E | A | B | D |
150 | A | A | A | E | A | A | D |
151 | C | D | A | E | D | D | D |
152 | C | B | A | E | A | C | D |
153 | A | A | A | E | A | A | D |
154 | D | C | A | E | D | D | D |
155 | D | A | A | E | B | A | D |
156 | A | A | A | E | A | A | B |
157 | A | A | A | E | A | A | B |
158 | A | A | A | A | A | A | B |
159 | B | A | A | E | A | A | D |
160 | B | A | A | E | A | A | A |
161 | D | A | A | E | A | A | B |
162 | A | A | A | E | A | A | B |
163 | B | A | A | E | A | A | A |
164 | A | A | A | E | A | A | D |
165 | D | C | A | E | D | D | D |
166 | A | A | A | E | B | A | D |
167 | E | A | A | A | A | A | B |
168 | E | A | A | A | A | A | C |
169 | E | A | A | A | A | A | B |
170 | E | A | A | A | A | A | C |
171 | E | A | A | A | A | A | B |
172 | E | A | A | A | A | A | B |
173 | E | A | A | A | A | A | C |
174 | E | A | A | A | A | A | B |
175 | D | C | A | E | D | B | D |
176 | E | D | D | D | D | D | D |
177 | E | A | A | C | D | A | D |
178 | E | A | A | A | D | A | D |
179 | D | A | A | E | B | A | D |
180 | B | A | A | E | C | A | D |
181 | D | A | A | E | B | A | D |
182 | B | A | A | E | A | A | C |
183 | D | A | A | E | A | A | D |
184 | D | A | A | E | C | A | D |
185 | D | A | A | E | A | A | D |
186 | D | A | A | E | A | A | C |
187 | C | A | A | E | A | A | D |
188 | D | A | A | E | A | A | D |
189 | C | A | A | E | A | A | D |
190 | D | A | A | E | A | A | C |
191 | D | A | A | E | A | A | C |
192 | D | A | A | E | B | A | D |
193 | D | A | A | E | A | A | C |
194 | D | A | A | E | B | A | D |
195 | D | A | A | E | A | A | C |
196 | D | A | A | E | A | A | D |
197 | D | A | A | E | C | A | D |
198 | C | A | A | E | D | A | D |
199 | D | A | A | E | B | A | D |
200 | D | A | A | E | C | A | D |
201 | D | A | A | E | B | A | D |
202 | D | A | A | E | B | A | D |
203 | D | A | A | E | D | A | D |
204 | E | B | A | A | A | B | B |
205 | E | A | A | A | A | A | C |
206 | E | B | A | A | B | B | D |
207 | E | A | A | A | B | A | B |
208 | E | B | A | B | A | B | B |
209 | E | B | A | B | B | A | C |
210 | E | C | A | A | A | B | B |
211 | E | B | A | D | A | B | D |
212 | E | B | A | D | C | A | D |
213 | E | A | A | C | B | A | B |
214 | E | C | A | C | B | B | C |
215 | E | A | A | A | D | A | B |
216 | E | B | A | D | B | B | D |
217 | E | C | A | D | B | A | D |
218 | E | B | A | D | D | B | D |
219 | E | B | A | D | D | B | D |
220 | E | A | A | A | A | A | D |
221 | E | A | A | A | A | B | C |
222 | D | A | B | E | D | A | D |
223 | D | A | A | E | B | A | D |
224 | D | A | A | E | C | A | D |
225 | D | A | A | E | B | A | D |
226 | D | A | A | E | D | A | D |
227 | D | A | A | E | A | A | D |
228 | D | A | A | E | D | A | D |
229 | D | A | A | E | D | A | D |
230 | E | A | A | D | B | A | B |
231 | E | A | A | D | B | A | B |
232 | E | A | A | D | A | A | D |
233 | E | A | A | C | A | A | B |
234 | E | A | A | D | A | A | D |
235 | E | C | D | D | C | C | D |
236 | E | A | A | D | A | B | D |
237 | E | A | A | D | A | B | C |
238 | E | A | A | D | D | A | D |
239 | E | A | A | D | A | B | A |
240 | E | A | A | D | C | A | D |
241 | E | A | A | D | B | A | D |
242 | E | B | D | D | D | B | D |
243 | E | A | A | D | D | B | D |
244 | E | A | A | D | D | A | D |
245 | E | A | A | D | C | A | C |
246 | E | B | A | D | D | B | D |
247 | E | A | A | D | D | A | D |
248 | E | D | D | D | D | D | D |
249 | E | D | D | D | D | A | D |
250 | E | A | A | D | D | A | D |
251 | E | B | A | D | D | A | D |
252 | E | A | A | D | D | A | D |
253 | E | A | A | D | D | A | D |
254 | E | A | A | D | D | A | D |
255 | E | A | A | D | D | B | D |
256 | E | A | A | D | D | A | D |
257 | E | C | A | D | D | A | D |
258 | E | C | A | D | D | A | D |
259 | E | A | A | D | D | B | D |
260 | E | B | D | D | D | B | D |
261 | E | B | A | D | D | B | D |
262 | E | C | B | D | D | C | D |
263 | E | C | C | D | D | C | D |
264 | E | B | A | D | D | C | C |
265 | E | A | A | D | D | B | D |
266 | E | A | A | A | D | A | D |
267 | E | A | A | A | B | A | D |
268 | E | A | A | A | C | A | D |
269 | E | A | A | A | C | A | D |
270 | E | A | A | A | D | A | D |
271 | E | C | D | D | D | C | D |
272 | E | B | E | E | E | B | E |
273 | E | B | A | D | D | B | D |
274 | E | B | B | D | D | A | D |
275 | E | A | A | D | D | A | D |
276 | E | C | C | B | D | B | D |
277 | E | A | B | D | C | A | D |
278 | E | A | A | D | B | A | D |
279 | E | A | A | B | B | A | D |
280 | E | A | A | D | D | A | D |
281 | E | B | A | A | A | C | D |
282 | E | B | A | D | D | D | D |
283 | E | B | A | D | C | C | D |
284 | E | B | A | A | A | C | D |
285 | E | D | B | D | C | D | D |
286 | E | D | D | D | D | D | D |
287 | E | C | A | D | C | D | D |
288 | E | D | A | D | B | C | D |
289 | E | D | D | D | C | D | D |
290 | E | D | D | D | D | D | D |
291 | E | D | D | D | D | D | D |
292 | E | A | B | D | C | B | D |
293 | E | D | D | D | D | C | D |
294 | E | D | D | D | D | C | D |
295 | E | D | D | D | D | D | D |
296 | E | C | D | D | D | C | D |
297 | E | D | D | D | D | C | D |
298 | E | D | D | D | D | C | D |
299 | E | D | D | D | D | B | D |
300 | E | C | A | C | D | B | D |
301 | E | A | A | D | C | A | D |
302 | E | A | A | D | D | A | D |
303 | E | A | A | D | D | A | D |
304 | E | A | A | D | D | A | D |
305 | E | B | A | C | B | B | D |
306 | E | B | A | D | D | B | D |
307 | E | B | A | D | D | B | D |
308 | E | B | A | B | D | B | D |
309 | E | A | A | A | D | A | D |
310 | E | B | A | A | C | B | D |
311 | E | A | B | B | B | A | C |
312 | E | C | B | C | B | C | C |
313 | E | A | A | D | D | A | D |
314 | E | D | A | D | D | C | D |
315 | E | A | A | C | D | A | D |
316 | E | A | A | C | D | A | D |
317 | E | A | A | D | C | A | D |
318 | E | A | A | A | A | A | D |
319 | E | A | A | D | D | A | D |
320 | E | A | A | D | D | A | D |
321 | E | A | D | D | C | A | D |
322 | E | A | A | D | D | A | D |
323 | E | A | D | D | D | C | D |
324 | E | A | A | B | B | A | D |
325 | E | A | A | A | A | A | D |
326 | E | B | A | A | B | A | C |
327 | E | A | A | A | A | A | C |
328 | E | A | A | A | C | A | C |
329 | E | A | A | A | C | A | C |
330 | E | C | A | A | A | B | D |
331 | E | A | A | A | C | A | C |
332 | E | A | A | A | C | A | D |
333 | E | D | A | A | A | D | A |
334 | E | B | D | D | D | A | D |
335 | E | D | D | A | C | D | C |
336 | E | D | B | B | D | C | C |
337 | E | D | D | D | D | A | D |
338 | E | A | B | D | D | A | C |
339 | E | A | B | B | B | A | C |
340 | E | D | D | D | D | D | D |
341 | E | D | D | D | D | D | D |
342 | E | D | B | C | D | D | D |
343 | E | B | A | B | D | A | D |
344 | E | D | D | B | D | D | D |
345 | E | A | A | C | B | A | D |
346 | E | C | A | D | D | A | D |
347 | E | A | C | C | D | A | D |
348 | E | C | A | C | D | B | C |
349 | E | D | D | D | D | D | D |
350 | E | D | D | B | B | B | B |
351 | E | D | D | A | B | D | C |
352 | E | C | A | A | C | B | C |
353 | E | D | D | D | D | D | D |
354 | E | D | B | A | D | D | D |
355 | E | A | D | B | D | A | D |
356 | E | C | D | D | D | A | D |
357 | E | C | D | D | D | A | D |
358 | E | A | A | C | D | A | D |
359 | E | A | A | C | D | A | D |
360 | E | A | A | D | D | A | D |
361 | E | A | A | B | B | A | B |
362 | E | A | A | A | D | A | D |
363 | E | A | A | A | B | A | B |
364 | E | A | A | A | D | A | D |
365 | E | A | A | A | C | A | D |
366 | E | A | A | B | D | A | D |
367 | E | A | A | A | D | A | D |
368 | E | A | A | A | B | A | B |
369 | E | A | A | A | C | A | D |
370 | E | A | A | A | B | A | B |
371 | E | A | A | A | B | A | B |
372 | E | A | A | B | D | A | D |
373 | E | A | A | C | C | A | C |
374 | E | A | A | C | D | A | D |
375 | E | A | A | D | D | A | D |
376 | E | A | A | D | D | A | D |
377 | E | A | A | D | D | A | D |
378 | E | A | A | A | B | A | D |
379 | E | A | A | A | B | A | C |
380 | E | A | A | A | B | A | C |
381 | E | A | A | A | A | A | C |
382 | E | A | A | A | A | A | B |
383 | E | A | A | A | B | A | D |
384 | E | D | A | A | D | B | D |
385 | E | B | A | A | C | A | D |
386 | E | C | D | A | C | B | D |
387 | E | D | A | A | C | D | D |
388 | E | C | D | C | D | D | D |
389 | E | A | A | A | C | A | D |
390 | E | B | C | A | C | B | D |
391 | E | D | C | A | C | D | D |
392 | E | D | D | A | D | D | D |
393 | E | D | A | B | D | D | D |
394 | E | D | D | B | D | D | D |
395 | E | D | C | A | B | B | D |
396 | E | D | C | A | D | D | D |
397 | E | D | B | A | B | D | D |
398 | E | D | A | A | D | C | D |
399 | E | D | D | B | D | D | D |
400 | E | D | D | D | D | D | D |
401 | E | D | D | A | D | D | D |
402 | E | B | A | A | D | B | D |
403 | E | C | A | A | D | B | D |
404 | E | D | B | D | D | B | D |
405 | E | B | B | B | D | A | D |
406 | E | C | C | A | D | B | D |
407 | E | C | D | D | D | B | D |
408 | E | A | A | A | A | A | A |
409 | E | A | A | A | A | A | B |
410 | E | D | D | D | D | C | D |
411 | E | D | D | D | D | D | D |
412 | E | D | D | C | D | D | D |
413 | E | D | D | D | D | D | B |
414 | E | A | A | A | A | A | A |
415 | E | A | A | A | A | A | A |
416 | E | A | A | D | C | A | D |
417 | E | A | A | A | A | A | B |
418 | E | B | A | C | C | B | D |
419 | E | A | A | A | B | A | D |
420 | E | A | A | D | C | A | D |
421 | E | A | A | A | A | A | D |
422 | E | A | A | D | B | A | D |
423 | E | A | A | A | A | A | B |
424 | E | C | A | C | D | D | D |
425 | E | A | D | D | B | A | D |
426 | E | A | C | D | D | B | D |
427 | E | A | C | D | B | A | D |
428 | E | A | D | C | B | A | D |
429 | E | A | A | D | B | A | D |
430 | E | B | C | D | B | A | D |
431 | E | A | A | A | B | A | C |
432 | E | A | A | A | A | A | B |
433 | E | A | A | A | A | A | B |
434 | E | A | A | A | B | B | D |
435 | E | D | B | D | D | D | D |
436 | E | D | D | D | D | B | D |
437 | E | C | D | D | D | D | D |
438 | E | A | A | B | B | A | D |
439 | E | A | A | B | A | A | C |
440 | E | A | A | D | D | A | D |
441 | E | D | A | A | A | D | B |
442 | E | A | A | C | A | A | D |
443 | E | A | A | B | D | A | D |
444 | E | A | A | B | D | A | D |
445 | E | A | A | D | D | A | D |
446 | E | A | A | D | C | A | D |
447 | E | D | D | D | D | C | D |
448 | E | D | D | D | D | D | D |
449 | E | E | E | E | E | E | E |
450 | E | A | A | A | A | A | C |
451 | E | A | A | A | A | A | C |
452 | E | D | D | D | D | D | D |
453 | E | D | D | D | D | D | D |
454 | E | A | A | C | B | A | C |
455 | E | A | A | D | C | A | D |
456 | E | A | A | A | B | A | D |
457 | E | A | A | A | A | A | D |
458 | E | B | A | C | D | A | D |
459 | E | D | A | C | C | A | C |
460 | E | A | A | D | D | A | D |
461 | E | A | A | D | D | A | D |
462 | E | A | A | D | D | A | D |
463 | E | A | A | D | C | A | C |
464 | E | A | A | B | D | A | D |
465 | E | A | A | A | C | A | C |
466 | E | A | A | A | D | A | D |
467 | E | A | A | A | D | A | B |
468 | E | A | A | A | B | A | D |
469 | E | A | A | A | A | A | A |
470 | E | A | A | A | A | A | A |
471 | E | A | A | B | C | A | B |
472 | E | A | A | C | D | A | C |
473 | E | A | A | A | D | A | B |
474 | E | A | A | A | B | A | D |
475 | E | A | A | A | A | A | D |
476 | E | A | A | A | A | A | A |
477 | E | A | A | A | A | A | B |
478 | E | A | A | A | A | A | D |
479 | E | A | A | A | A | A | D |
480 | E | A | A | A | A | A | B |
481 | E | B | A | A | D | A | B |
482 | E | B | C | C | D | C | D |
483 | E | A | A | D | D | A | D |
484 | E | B | A | C | D | B | D |
485 | E | B | A | C | D | B | D |
486 | E | A | A | B | D | A | D |
487 | E | A | A | D | D | A | D |
488 | E | C | A | B | D | B | D |
489 | E | A | A | D | D | A | D |
490 | E | D | D | D | D | C | D |
491 | E | D | B | D | D | C | D |
492 | E | A | B | D | D | A | D |
493 | E | A | A | A | C | A | B |
494 | E | A | A | A | A | A | B |
495 | E | A | A | A | A | A | A |
496 | C | A | A | A | A | A | B |
497 | E | D | A | B | D | C | D |
498 | E | D | A | D | D | C | D |
499 | E | D | A | B | B | B | D |
500 | E | A | A | C | C | A | D |
501 | C | A | A | A | A | A | D |
502 | E | D | B | D | D | D | D |
503 | E | D | D | C | D | D | D |
504 | E | A | A | D | D | A | D |
505 | E | D | D | A | B | D | C |
506 | E | D | C | D | D | D | D |
507 | E | A | A | A | A | A | D |
508 | E | A | A | A | A | A | D |
509 | E | A | A | A | A | A | D |
510 | E | A | A | A | A | A | D |
511 | E | A | A | A | A | A | D |
512 | E | A | A | A | A | A | D |
513 | E | C | A | D | D | B | D |
514 | E | A | A | D | D | A | D |
515 | E | A | E | E | E | A | E |
516 | E | A | A | A | A | A | D |
517 | E | A | A | B | A | A | D |
518 | E | A | A | D | D | A | D |
519 | E | A | A | A | A | A | D |
520 | E | A | A | D | D | A | D |
521 | E | A | A | A | A | A | B |
522 | E | A | A | D | B | A | D |
523 | E | D | D | D | D | D | D |
524 | E | A | E | E | E | A | E |
525 | E | A | A | D | C | A | D |
526 | E | A | A | D | C | A | D |
527 | E | A | A | A | A | A | C |
528 | E | A | A | A | A | A | A |
529 | E | A | A | D | D | A | D |
530 | E | D | D | D | D | C | D |
531 | E | A | A | B | D | A | D |
532 | E | A | A | C | D | A | D |
533 | E | A | A | B | D | A | D |
534 | E | A | A | D | D | A | D |
535 | E | A | A | B | D | A | D |
536 | E | A | A | D | D | A | D |
537 | E | E | E | E | E | E | E |
538 | E | E | E | E | E | E | E |
539 | E | E | E | E | E | E | E |
540 | E | B | B | D | D | A | D |
541 | E | C | D | D | D | A | D |
542 | E | C | D | C | D | B | D |
543 | E | A | A | A | C | A | D |
544 | E | A | A | D | D | A | D |
545 | E | A | A | D | D | A | D |
546 | E | A | A | D | D | A | D |
547 | E | A | A | B | D | A | D |
548 | E | A | A | D | D | A | D |
549 | E | A | A | D | D | A | C |
550 | E | A | A | C | D | A | D |
551 | E | A | A | D | D | A | D |
552 | E | A | A | B | D | A | D |
553 | E | A | A | D | D | A | D |
554 | E | A | A | B | C | A | D |
555 | E | A | A | D | D | A | D |
556 | E | A | A | C | D | A | D |
557 | E | E | E | E | E | E | E |
558 | E | D | D | D | D | B | D |
559 | E | A | B | D | D | A | D |
560 | E | A | A | A | A | A | B |
561 | E | A | A | A | A | A | D |
562 | E | A | A | A | B | A | C |
563 | E | A | A | A | A | A | B |
Claims (23)
- 一種具有式I之化合物: I 其中 R1 選自由以下組成之群組:氫、C1 -C8 烷基、C1 -C8 經取代的烷基、C2 -C8 烯基、C2 -C8 經取代的烯基、C2- C8 炔基、C2 -C8 經取代的炔基、C3 -C8 環烷基、C3 -C8 經取代的環烷基、C3 -C8 雜環烷基、C3 -C8 經取代的雜環烷基、C5 -C7 雜芳基、C5 -C7 經取代的雜芳基、苯基、經取代的苯基、苄基、和經取代的苄基; 每個R2 、R3 、R4 、和R5 獨立地選自由以下組成之群組:氫、鹵素、氰基、硝基、C1 -C8 烷基、C1 -C8 經取代的烷基、C2 -C8 烯基、C2 -C8 經取代的烯基、C2 -C8 炔基、C2 -C8 經取代的炔基、C1 -C8 烷氧基、和C1 -C8 經取代的烷氧基; R6 選自由以下組成之群組:氫、C1 -C8 烷基、C1 -C8 經取代的烷基、C2- C8 烯基、C2- -C8 經取代的烯基、C2- C8 炔基、C1 -C8 經取代的炔基、C1 -C8 烷氧基、C1 -C8 經取代的烷氧基、硫醇、烷硫基、和經取代的烷硫基; 或R6 和R7 可以共價鍵合在一起以形成飽和的或不飽和的C3 -C8 雜環烷基或C3 -C8 經取代的雜環烷基基團; 每個R7 和R8 獨立地選自由以下組成之群組:氫、C1 -C8 烷基、C1 -C8 經取代的烷基、C2- C8 烯基、C2 -C8 經取代的烯基、C2- C8 炔基、C2 -C8 經取代的炔基、C3 -C8 環烷基、C3 -C8 經取代的環烷基、苯基、經取代的苯基、苄基、和經取代的苄基; 或R7 和R8 可以共價鍵合在一起以形成飽和的或不飽和的C3 -C8 雜環烷基或C3 -C8 經取代的雜環烷基基團; 其中任何和所有雜環可含有至多三個選自由O、N和S組成之群組的雜原子; 或其互變異構物或鹽。
- 如請求項1所述之化合物,其中R1 選自由以下組成之群組:C1 -C8 烷基、C1 -C8 經取代的烷基、C2 -C8 炔基、C2 -C8 經取代的炔基、C3 -C8 環烷基、C3 -C8 經取代的環烷基、苯基、經取代的苯基、苄基、和經取代的苄基。
- 如請求項2所述之化合物,其中R1 選自由以下組成之群組:苄基和經取代的苄基。
- 如請求項1-3所述之化合物,其中R2 和R5 二者皆為氫。
- 如請求項4所述之化合物,其中R3 和R4 獨立地選自由以下組成之群組:鹵素、C1 -C8 烷基、C1 -C8 經取代的烷基、和C1 -C8 烷氧基。
- 如請求項5所述之化合物,其中R3 和R4 二者皆為CH3 。
- 如請求項1-3所述之化合物,其中R4 和R5 二者皆為氫。
- 如請求項7所述之化合物,其中R2 和R3 獨立地選自由以下組成之群組:鹵素、C1 -C8 烷基、C1 -C8 經取代的烷基、和C1 -C8 烷氧基。
- 如請求項8所述之化合物,其中R2 和R3 二者皆為CH3 。
- 如請求項1-10中任一項所述之化合物,其中每個R7 和R8 獨立地選自由以下組成之群組:氫、C1 -C8 烷基、C1 -C8 經取代的烷基、C2- C8 烯基、C3 -C8 環烷基、苯基、經取代的苯基、苄基、和經取代的苄基。
- 如請求項1-11中任一項所述之化合物,其中R6 選自由以下組成之群組:氫、C1 -C8 烷基、C1 -C8 經取代的烷基、硫醇、烷硫基、和經取代的烷硫基。
- 一種根據表1中的化合物的任一者的化合物。
- 一種殺真菌劑組成物,其包含植物學上可接受量的具有式I中任一者的化合物或如請求項1-12中任一項所述之化合物和載體。
- 如請求項13所述之組成物,其中該載體係增稠劑、乳化劑、流變劑、分散劑和聚合物中的一種或多種。
- 一種控制真菌侵襲植物之方法,該方法包括用植物學上可接受的量的具有式I中任一者的化合物或如請求項1-14中任一項所述之化合物與該植物相鄰的區域、適於該植物生長的土壤、該植物的根和該植物的葉子接觸。
- 具有式I中任一者的化合物或如請求項1-14中任一項所述之化合物,用於在控制真菌病原體中使用。
- 如請求項16所述之化合物,其中該真菌病原體係Zymoseptoria tritici 、禾旋孢腔菌(Cochliobolus sativus)、小麥葉鏽菌(Puccinia triticina )、條形柄鏽菌(Puccinia striiformis )、蘋果黑星病菌(Venturia inaequalis )、玉米黑粉菌(Ustilago maydis )、葡萄白粉菌(Uncinula necator )、大麥雲紋病菌(Rhynchosporium commune )、稻瘟病菌(Magnaporthe grisea )、豆薯層鏽菌(Phakopsora pachyrhizi )、Parastagonospora nodorum 、瓜炭疽病菌(Glomerella lagenarium )、甜菜生尾孢(Cercospora beticola )、番茄早疫病菌(Alternaria solani )、圓核腔菌(Pyrenophora teres )、小麥白粉病菌(Blumeria graminis f. sp. tritici )、大麥白粉病菌(Blumeria graminis f. sp. hordei )、菊科白粉菌(Erysiphe cichoracearum )、北美大豆猝死綜合症病菌(Fusarium virguliforme )、立枯絲核菌(Rhizoctonia solani )、終極腐黴菌(Pythium ultimum )和灰黴菌(Botrytis cinerea )之一。
- 如請求項16所述之化合物,其中該化合物治療來自該真菌病原體的以下疾病之一:小麥斑葉枯病(Zymoseptoria tritici )、大麥斑點病(禾旋孢腔菌(Cochliobolus sativus ))、小麥褐銹病(小麥葉鏽菌(Puccinia triticina ))、條銹病(條形柄鏽菌(Puccinia striiformis ))、蘋果黑星病(蘋果黑星病菌(Venturia inaequalis ))、玉米皰黑穗病(玉米黑粉菌(Ustilago maydis ))、葡萄白粉病(葡萄白粉菌(Uncinula necator ))、大麥雲紋病(大麥雲紋病菌(Rhynchosporium commune ))、稻瘟病(稻瘟病菌(Magnaporthe grisea ))、亞洲大豆鏽菌病(豆薯層鏽菌(Phakopsora pachyrhizi ))、小麥穎斑枯病(Parastagonospora nodorum )、葫蘆科炭疽病(瓜炭疽病菌(Glomerella lagenarium ))、甜菜褐斑病(甜菜生尾孢(Cercospora beticola ))、番茄早疫病(番茄早疫病菌(Alternaria solani ))、大麥網狀斑點病(圓核腔菌(Pyrenophora teres ))、小麥白粉病(小麥白粉病菌(Blumeria graminis f. sp.tritici ))、大麥白粉病(大麥白粉病菌(Blumeria graminis f. sp. hordei ))、葫蘆科白粉病(菊科白粉菌(Erysiphe cichoracearum ))、大豆猝死綜合症(北美大豆猝死綜合症病菌(Fusarium virguliforme ))、幼苗頸腐病或猝倒病(立枯絲核菌(Rhizoctonia solani ))、爛根病(終極腐黴菌(Pythium ultimum ))、灰黴病(灰黴菌(Botrytis cinerea ))。
- 一種用於控制真菌病原體在組成物,該組成物包含植物學上可接受量的具有式I中任一者的化合物或如請求項1-18中任一項所述之化合物和載體。
- 如請求項19所述之組成物,其中該真菌病原體係Zymoseptoria tritici 、禾旋孢腔菌、小麥葉鏽菌、條形柄鏽菌、蘋果黑星病菌、玉米黑粉菌、葡萄白粉菌、大麥雲紋病菌、稻瘟病菌、豆薯層鏽菌、Parastagonospora nodorum 、瓜炭疽病菌、甜菜生尾孢、番茄早疫病菌、圓核腔菌、小麥白粉病菌、大麥白粉病菌、菊科白粉菌、北美大豆猝死綜合症病菌、立枯絲核菌、終極腐黴菌和灰黴菌之一。
- 如請求項19所述之組成物,其中該組成物治療來自該真菌病原體的以下疾病之一:小麥斑葉枯病(Zymoseptoria tritici )、大麥斑點病(禾旋孢腔菌)、小麥褐銹病(小麥葉鏽菌)、條銹病(條形柄鏽菌)、蘋果黑星病(蘋果黑星病菌)、玉米皰黑穗病(玉米黑粉菌)、葡萄白粉病(葡萄白粉菌)、大麥雲紋病(大麥雲紋病菌)、稻瘟病(稻瘟病菌)、亞洲大豆鏽菌病(豆薯層鏽菌)、小麥穎斑枯病(Parastagonospora nodorum )、葫蘆科炭疽病(瓜炭疽病菌)、甜菜褐斑病(甜菜生尾孢)、番茄早疫病(番茄早疫病菌)、大麥網狀斑點病(圓核腔菌)、小麥白粉病(小麥白粉病菌)、大麥白粉病(大麥白粉病菌)、葫蘆科白粉病(菊科白粉菌)、大豆猝死綜合症(北美大豆猝死綜合症病菌)、幼苗頸腐病或猝倒病(立枯絲核菌)、爛根病(終極腐黴菌)、灰黴病(灰黴菌)。
- 如請求項19所述之組成物,其中該疾病係小麥斑葉枯病、大麥斑點病、小麥褐銹病、和亞洲大豆鏽菌病之一。
- 一種用植物學上可接受量的具有式I中任一者的化合物或如請求項1-12中任一項所述之化合物處理的種子。
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