TW202106290A - 用於調節補體活性之組成物及方法 - Google Patents

用於調節補體活性之組成物及方法 Download PDF

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Publication number
TW202106290A
TW202106290A TW109113822A TW109113822A TW202106290A TW 202106290 A TW202106290 A TW 202106290A TW 109113822 A TW109113822 A TW 109113822A TW 109113822 A TW109113822 A TW 109113822A TW 202106290 A TW202106290 A TW 202106290A
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TW
Taiwan
Prior art keywords
sustained
release formulation
polypeptide
release
zirupram
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TW109113822A
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English (en)
Chinese (zh)
Inventor
西蒙 瑞德
伊凡 塔卡貝里
王洪
Original Assignee
美商Ｒａ製藥公司
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Application filed by 美商Ｒａ製藥公司 filed Critical 美商Ｒａ製藥公司
Publication of TW202106290A publication Critical patent/TW202106290A/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW109113822A 2019-04-24 2020-04-24 用於調節補體活性之組成物及方法 TW202106290A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201962837978P 2019-04-24 2019-04-24
US62/837,978 2019-04-24
US201962947183P 2019-12-12 2019-12-12
US201962947188P 2019-12-12 2019-12-12
US62/947,183 2019-12-12
US62/947,188 2019-12-12

Publications (1)

Publication Number Publication Date
TW202106290A true TW202106290A (zh) 2021-02-16

Family

ID=70977557

Family Applications (1)

Application Number Title Priority Date Filing Date
TW109113822A TW202106290A (zh) 2019-04-24 2020-04-24 用於調節補體活性之組成物及方法

Country Status (13)

Country Link
US (1) US20220211799A1 (enExample)
EP (1) EP3958842A1 (enExample)
JP (2) JP7726791B2 (enExample)
KR (1) KR20220004039A (enExample)
CN (1) CN113710230A (enExample)
AU (1) AU2020261059A1 (enExample)
BR (1) BR112021017820A2 (enExample)
CA (1) CA3137895A1 (enExample)
IL (1) IL287079A (enExample)
MX (1) MX2021013010A (enExample)
SG (1) SG11202109837SA (enExample)
TW (1) TW202106290A (enExample)
WO (1) WO2020219822A1 (enExample)

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* Cited by examiner, † Cited by third party
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AP2016009612A0 (en) 2014-06-12 2016-12-31 Ra Pharmaceuticals Inc Modulation of complement activity
HRP20211824T1 (hr) 2015-01-28 2022-03-04 Ra Pharmaceuticals, Inc. Modulatori aktivnosti komplementa
HUE061759T2 (hu) 2015-12-16 2023-08-28 Ra Pharmaceuticals Inc Komplement aktivitás modulátorai
BR112019011053A2 (pt) 2016-12-07 2019-10-15 Ra Pharmaceuticals Inc moduladores da atividade do complemento
CN113226368A (zh) * 2018-10-22 2021-08-06 Ra制药公司 采用齐鲁考普的神经疾病治疗

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MXPA05011886A (es) 2003-05-15 2006-02-17 Tanox Inc Metodos y composiciones para la prevencion y tratamiento de septicemia.
CN1289066C (zh) * 2003-09-18 2006-12-13 中国人民解放军第二军医大学 胰高血糖素样肽－1缓释微球制剂及其用途
US20060270590A1 (en) 2005-03-29 2006-11-30 Lockwood Samuel F Reduction in complement activation and inflammation during tissue injury by carotenoids, carotenoid analogs, or derivatives thereof
EP1885398B1 (en) 2005-05-26 2015-07-08 The Regents of the University of Colorado, a body corporate Inhibition of the alternative complement pathway for treatment of traumatic brain injury, spinal cord injury and related conditions
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MX2009009738A (es) 2007-04-30 2009-09-24 Alcon Res Ltd Tratamiento de degeneracion macular relacionada con la edad usando inhibidores de factor d de complemento.
BRPI0812767A2 (pt) 2007-06-07 2014-12-02 Genentech Inc Anticorpos para c3b e métodos para prevenção e tratamento de distúrbios associados ao complemento
WO2009014633A1 (en) 2007-07-20 2009-01-29 Trustees Of The University Of Pennsylvania Method of treating acute respiratory distress syndrome
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HUE061759T2 (hu) 2015-12-16 2023-08-28 Ra Pharmaceuticals Inc Komplement aktivitás modulátorai
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Also Published As

Publication number Publication date
KR20220004039A (ko) 2022-01-11
CA3137895A1 (en) 2020-10-29
US20220211799A1 (en) 2022-07-07
AU2020261059A1 (en) 2021-10-14
JP2022530042A (ja) 2022-06-27
SG11202109837SA (en) 2021-10-28
MX2021013010A (es) 2022-01-18
BR112021017820A2 (pt) 2022-02-08
IL287079A (en) 2021-12-01
JP2025118607A (ja) 2025-08-13
EP3958842A1 (en) 2022-03-02
JP7726791B2 (ja) 2025-08-20
CN113710230A (zh) 2021-11-26
WO2020219822A1 (en) 2020-10-29

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