TW202045146A - Adhesive sheet for teeth - Google Patents

Abstract

The present invention relates to an adhesive sheet for teeth equipped with two layers that heighten the transparency of the sheet when adhered to a tooth or a peripheral portion of a tooth and permit visual recognition of changes over time in the innermost layer which constitutes the adhering surface. Specifically, the present invention relates to an adhesive sheet for teeth obtained by laminating an innermost adhesive layer (X) that contains a medicinal component (xa) and has adhesiveness to teeth and solubility in water and an outermost protective layer (Y) that is a layer having lower adhesiveness to teeth and solubility in water than the innermost adhesive layer (X), contains a water-insoluble polymer (ya), and contains one or two selected from propylene glycol (yb) and glycerin (xc).

Description

Dental patch

The present invention relates to a dental patch.

Whether it is to maintain health or from a cosmetic point of view, proper care of the teeth and gums and other peripheral parts of the teeth is indispensable every day. If adequate care is not taken, tartar or dirt will adhere to and accumulate on the surface of the teeth, resulting in unwanted staining or degeneration of the gums, which can cause periodontal disease or gingivitis. It may also be a factor in tooth looseness or pain. , And it may damage the beauty. In order to prevent or treat various symptoms related to teeth or tooth peripherals, and to impart aesthetics, a dental patch containing the required ingredients was developed and tried to attach it to teeth or teeth peripherals. And make the required ingredients work for a certain time.

For example, Patent Document 1 discloses a dental patch, which has layers (A) and (B) whose pH values when dissolved in water show mutually different values, and the latter layer contains phytic acid, etc., By attaching the dental patch to the teeth, the pH environment on the surface of the teeth is changed over time, and the phytic acid etc. can work effectively, thereby exerting a whitening effect on the teeth. In addition, Patent Document 2 discloses a film-like external preparation for periodontal disease, which includes the lowermost adhesive layer and the uppermost protective layer directly attached to the side of the teeth and/or gums, and each layer is opposed to the teeth and/or There are differences in gum adhesion and saliva dissolution rate; and the following attempts have been made: the external agent as a whole is set to a dissolution rate that does not completely dissolve saliva within at least 3 hours from the start of sleep to sleep. This wants to make it stay in the oral cavity for a long time, and fully exert the effect of the medicinal ingredient during sleep.

(Patent Document 1) International Publication No. 2014/069595 (Patent Document 2) Japanese Patent Laid-Open No. 2016-84287

The present invention provides a patch for teeth, which is formed by laminating the innermost adhesive layer (X) and the outermost protective layer (Y), The innermost adhesive layer (X) has adhesion to teeth and solubility in water, and contains medicinal ingredients (xa); The outermost protective layer (Y) is a layer whose adhesion to teeth and water solubility are lower than that of the innermost adhesive layer (X), and contains a water-insoluble polymer (ya), and contains selected from propylene glycol (yb) And one or two of glycerin (yc), Preferably, the present invention provides a dental patch, which is formed by laminating the innermost adhesive layer (X) and the outermost protective layer (Y), The innermost adhesive layer (X) has adhesion to teeth and solubility in water, and contains medicinal ingredients (xa); The outermost protective layer (Y) is a layer whose adhesion to teeth and water solubility are lower than that of the innermost adhesive layer (X), and contains a water-insoluble polymer (ya), and contains selected from propylene glycol (yb) And glycerin (yc) one or two, and the content of component (yb), and the mass ratio of the total content of component (yb) and component (yc) ((yb)/((yb) + (yc)) )) is greater than 0.5.

Although the sheets described in the above patent documents can bring the required effects to the teeth or their peripheral parts, all the sheets do not sufficiently ensure the transparency of the outermost layer at the time of attachment, so that the dissolution of the sheet cannot be visually recognized The condition or the diffusion of the required ingredients, and it is difficult to judge the appropriate time of attachment by visual recognition.

Therefore, the inventors conducted various studies and found that by having at least two layers, the innermost adhesive layer and the outermost protective layer showing differences in the adhesion to teeth and water solubility , And in order to bring the desired effect to the teeth or the periphery of the teeth, the innermost adhesive layer contains medicinal ingredients, and the outermost protective layer contains at least one of water-insoluble polymers and propylene glycol or glycerin. A tooth patch with the outermost protective layer that ensures good moldability and shows excellent transparency.

That is, the present invention relates to a dental patch provided with two layers that increase the transparency of the outermost layer when it is attached to a tooth or the periphery of a tooth, so that the innermost layer constituting the attachment surface can be visually changed with time.

According to the dental patch of the present invention, since it is covered and protected by the outermost protective layer with higher transparency when it is attached to the tooth or the peripheral part of the tooth, it can be seen through the outermost protective layer to be more inside than the outermost protective layer The transmission and diffusion of the medicinal ingredients in the layer to the tooth or the periphery of the tooth changes over time, and the required time of application can be appropriately determined. In addition, the dental patch of the present invention can be visually assimilated with the teeth or the peripheral part of the teeth, thereby reducing the sensation of foreign bodies.

Hereinafter, the present invention will be described in detail. The dental patch of the present invention includes a structure with at least two layers of the innermost adhesive layer (X) and the outermost protective layer (Y) with higher transparency, and the innermost adhesive layer (X) is attached to Use it on the teeth or around the teeth. In this way, when the dental patch of the present invention is attached to a tooth or a peripheral portion of a tooth, the innermost adhesive layer (X) can be dissolved in saliva well, and can appropriately perform their specific functions. Specifically, the innermost adhesive layer (X) adheres well to the tooth or the periphery of the tooth, dissolves in the saliva before the outermost protective layer (Y), and makes the contained medicinal ingredients (xa) from one side It acts on the teeth or the periphery of the teeth. Meanwhile, compared with the innermost adhesive layer (X), the outermost protective layer (Y) does not excessively adhere to the teeth or the teeth around the oral cavity, and compared to the innermost adhesive layer (X), The outermost protective layer (Y) delays the dissolution of saliva. Therefore, the dissolution of saliva by the innermost adhesive layer (X) will not be unnecessarily hindered by saliva or the tongue. It can promote the good distribution of medicinal ingredients (xa) The tooth or the periphery of the tooth is transmitted and spread, and this change with time is recognized through the outermost protective layer (Y).

Here, the term “tooth periphery” refers to the oral organs located around the teeth including gums and so-called gums. The dental patch of the present invention is attached only to the teeth, only to the periphery of the teeth, or all over the teeth. A sheet used by attaching both to the periphery of the tooth. Hereinafter, the "teeth or the peripheral parts of the teeth" are collectively referred to as "teeth, etc." In addition, with the exception of the stock solution used to manufacture the dental patch of the present invention, each mass is the mass in a dry state (dry mass).

The innermost adhesive layer (X) of the dental patch of the present invention has adhesion to teeth and water solubility, and a layer containing medicinal ingredients (xa), which is useful for using the present invention When using a tooth patch, it is a layer that is directly attached to the surface of the tooth. Thereby, when the dental patch of the present invention is attached to teeth, etc., the innermost adhesive layer (X) can be well attached to the teeth, etc. and gradually dissolved in saliva, thereby making the medicinal ingredient (xa) Transfer and spread from the innermost attachment layer (X) to the teeth, etc., which can bring the required effects to the required parts.

The medicinal ingredients (xa) contained in the innermost adhesive layer (X) include: ingredients effective for preventing or treating periodontal disease or gingivitis, ingredients effective for preventing tooth decay, or whitening Ingredients etc. Specifically, one or more selected from the group consisting of phytic acid, pyrophosphoric acid, tripolyphosphoric acid, glycyrrhizic acid, glycyrrhetinic acid, and salts thereof, potassium nitrate and fluorine, can be cited. Among them, from the viewpoint of a technology in which medicinal ingredients are expected to act concentratedly on the tooth surface, it is more preferable to use phytic acid or its salt, potassium nitrate, and fluoride. Examples of preferable fluorides include fluoride ion-donating compounds such as sodium fluoride, potassium fluoride, and ammonium fluoride, sodium monofluorophosphate, and the like. In particular, from the viewpoint of a simple and convenient technology for beautifying teeth, it is more preferable to use phytic acid or its salt.

From the viewpoint of effectively exerting effects on teeth, etc., the content of the medicinal ingredient (xa) in 100% by mass of the innermost adhesive layer (X) is preferably 0.05% by mass or more, more preferably 0.07% by mass or more , And more preferably 0.1% by mass or more. In addition, from the viewpoint of ensuring good permeability to teeth, the content of the medicinal component (xa) in 100% by mass of the innermost adhesive layer (X) is preferably 30% by mass or less, more preferably 20 Mass% or less, more preferably 15 mass% or less.

More specifically, the content of the medicinal component (xa) is preferably in the following range from the viewpoint of acting on teeth and the like and leading to a good state. When the medicinal component (xa) is phytic acid or its salt, the content of the component (xa) in 100% by mass of the innermost adhesive layer (X) is preferably 1-30% by mass in terms of acid conversion amount, and more It is preferably from 5 to 20% by mass, and more preferably from 10 to 15% by mass.

In order to ensure good solubility in saliva, it not only improves the transparency of the outermost protective layer (Y) but also increases the transparency of the innermost attachment layer (X), and imparts higher transparency to the dental patch as a whole, further From the viewpoint of enhancing the visualization of the dissolution and diffusion of the component (xa) to teeth, etc., the innermost adhesion layer (X) preferably further contains a nonionic surfactant (xb). The nonionic surfactant (xb) preferably contains either polyoxyethylene hydrogenated castor oil (xb-1) and polyglycerol fatty acid ester (xb-2), and more preferably contains polyoxyethylene hydrogenated castor. Both sesame oil (xb-1) and polyglycerol fatty acid ester (xb-2). As polyoxyethylene hydrogenated castor oil (xb-1), from the viewpoint of ensuring the adhesion to teeth and further improving the transparency of the innermost adhesion layer (X), the average addition of ethoxylate is preferred The number of moles is 20-60, more preferably 40-60. As polyglycerol fatty acid ester (xb-2), from the viewpoint of ensuring good solubility in saliva and further improving the transparency of the innermost adhesion layer (X), the fatty acid part constituting it is preferred It is derived from a fatty acid having 10 to 16 carbon atoms, and more preferably derived from a fatty acid having 12 to 14 carbon atoms. In addition, from the same viewpoint as the above, the average condensation degree of glycerin is preferably 5-12.

In terms of ensuring the adhesion to teeth and the solubility to saliva, and further improving the transparency of the innermost adhesion layer (X), the polyoxyethylene hydrogenated castor oil in the innermost adhesion layer (X) ( The mass ratio of the content of xb-1) to the content of polyglycerin fatty acid ester (xb-2) ((xb-1)/(xb-2)) is preferably 0.1 or more, more preferably 0.5 or more, and more preferably It is 1 or more, and is preferably 10 or less, more preferably 9 or less, and still more preferably 7 or less.

The innermost adhesive layer (X) can also contain nonionic surfactants other than polyoxyethylene hydrogenated castor oil (xb-1) and polyglycerol fatty acid esters (xb-2) as nonionic surfactants (xb) . Examples of the nonionic surfactant include those selected from polyoxyethylene alkyl ethers, polyoxyethylene polyoxypropylene copolymers, sucrose fatty acid esters, sorbitan fatty acid esters, glycerin fatty acid esters, and polyoxyethylene sorbitan Fatty acid esters, polyoxyethylene sorbitol fatty acid esters, polyoxyethylene glycerol fatty acid esters, polyoxyethylene glycol fatty acid esters, polyoxyethylene phytosterol and plant sterols, polyoxyethylene lanolin and wool Alcohol, polyoxyethylene alkyl amine and fatty amide, polyoxyethylene alkyl phenyl formaldehyde condensate, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene alkyl phenyl ether, polyoxyethylene alkyl phenyl ether and One type or two or more types of fatty acid ethanolamide. Among them, preferably one or two selected from sucrose fatty acid esters and polyoxyethylene sorbitan fatty acid esters.

From the viewpoint of maintaining the adhesion of the innermost attachment layer (X) to teeth and the solubility to saliva, and further improving the transparency of the innermost attachment layer (X), polyoxyethylene hydrogenated castor oil is included The total content of the nonionic surfactant (xb) of (xb-1) and polyglycerol fatty acid ester (xb-2) in 100% by mass of the innermost adhesive layer (X) is preferably 0.8% by mass or more, which is more It is preferably 2% by mass or more, more preferably 3% by mass or more, still more preferably 4% by mass or more, and more preferably 6% by mass or less, more preferably 5% by mass or less, and still more preferably 4.7% by mass or less.

In addition, from the same viewpoint as the above, the content of polyoxyethylene hydrogenated castor oil (xb-1) in 100% by mass of the innermost adhesion layer (X) is preferably 0.2 to 5.5% by mass, more preferably 0.6 -4.5% by mass, more preferably 1.5 to 3.5% by mass. Furthermore, from the same viewpoint as the above, the content of the polyglycerin fatty acid ester (xb-2) in 100% by mass of the innermost adhesion layer (X) is preferably 0.1-3% by mass, more preferably 0.2- 2.2% by mass, more preferably 0.5 to 2% by mass.

The innermost adhesive layer (X) may further contain fragrance (xc). As the fragrance (xc), for example, menthol, pulegol, valvone, anethole, cineole, methyl salicylate, cinnamaldehyde, eugenol, 3-menthol Oxypropane-1,2-diol, revanol, citronellyl acetate, linalol, linalyl acetate, geraniol, geranyl acetate, citronellol, limonene, menthone, menthyl acetate, N-substituted-p-menthane-3-carboxamide, pinene, caprylic aldehyde, citral, pulegone, carvyl acetate, dihydrocarvyl acetate, anisaldehyde, benzaldehyde, camphor, Lactone, ethyl acetate, ethyl butyrate, allyl cyclohexyl propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecanoic acid lactone, hexanal, acetic acid Butyl ester, isoamyl acetate, hexenol, dimethyl sulfide, cyclotene, furfural, trimethylpyridine, ethyl lactate, methyl lactate, ethyl thioacetate Other single-product flavor ingredients; strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mixed flavor, tropical fruit flavor and other blended flavor ingredients; peppermint oil, spearmint oil, Ceylon cinnamon oil, star anise oil, eucalyptus oil, wintergrass oil, cinnamon oil, clove oil, thyme oil, sage oil, scented perilla oil, nutmeg oil, anise oil, lemon oil, sweet oil, peppermint Oil, cardamom oil, coriander oil, basil oil, tangerine oil, lime oil, lavender oil, rosemary oil, ginger oil, grapefruit oil, bay oil, rudbeckia oil, caraway oil, marjoram Oil, geraniol oil, lemongrass oil, lemon balm oil, allspice oil, palmarosa oil, frankincense oil, pine needle oil, base lime oil, neroli oil, rose oil, jasmine oil and other natural fragrance ingredients, and will These natural flavor ingredients are processed to obtain flavor ingredients. From the viewpoint of bringing a good flavor and masking the peculiar smell of the component (xa) to reduce the uncomfortable feeling during application, the content of the component (xc) is more than 100% by mass in the innermost adhesive layer (X) It is preferably 0.1 to 3% by mass, more preferably 0.2 to 2% by mass, and still more preferably 0.3 to 1% by mass.

From the viewpoint of ensuring the good formability of the innermost adhesive layer (X) itself and the viewpoint of promoting the transmission and diffusion of the component (xa) to teeth, etc., it is preferable that the innermost adhesive layer (X) contains water-soluble性polymer (xd). Here, water solubility means that 0.1 g or more of ingredients are dissolved in 100 g of water at 25°C. As the water-soluble polymer (xd), specific examples include: selected from pullulan, hydroxyethyl cellulose, guar gum, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, gelatin, and agar One or more of them. Among them, from the viewpoint of improving the transparency of the innermost adhesive layer (X) and visualizing the transmission and diffusion of the component (xa) to teeth, etc., it is preferably selected from pullulan, agar, and hydroxypropylmethyl One or two of cellulose.

Regarding the content of the water-soluble polymer (xd), from the viewpoint of ensuring good formability of the innermost adhesive layer (X) itself, and the viewpoint of promoting the transfer and diffusion of the component (xa) to teeth, etc., water-soluble The content of the polymer (xd) in 100% by mass of the innermost adhesive layer (X) is preferably 30 to 70% by mass, more preferably 40 to 65% by mass, and still more preferably 45 to 60% by mass.

In addition to the above-mentioned components, the innermost adhesive layer (X) may also contain pH regulators such as sodium hydroxide or potassium hydroxide, humectants such as propylene glycol and glycerin, sodium saccharin or within a range that does not impair the effects of the present invention. Sweeteners such as sucralose, preservatives, pigments, etc. are used as ingredients other than the above. Among them, if potassium hydroxide is used as a pH adjuster, it can also help improve the solubility or dispersibility of the contained components in the dental patch. Furthermore, when using the dental patch of the present invention, it is more important from the viewpoint of maintaining good adhesion or flexibility and ensuring the solubility or dispersibility of the ingredients contained in the dental patch. It is ideal to maintain a moderate moisture content in the innermost adhesive layer (X) after the drying step during manufacturing. The water content in 100% by mass of the innermost adhesive layer (X) is preferably 5-16% by mass, more preferably 6-15% by mass, and still more preferably 7-14% by mass.

The outermost protective layer (Y) of the dental patch of the present invention is a layer that has lower adhesion to teeth and water solubility than the innermost adhesive layer (X), and contains a water-insoluble polymer (ya) , And contains one or two selected from propylene glycol (yb) and glycerin (yc). Thereby, the adhesion to teeth and the solubility to saliva can be made lower than the innermost attachment layer (X), and the moldability of the outermost protective layer (Y) is improved and excellent transparency is imparted. Therefore, when the dental patch of the present invention is attached to teeth, etc., the solubility to saliva is lower than that of the innermost attachment layer (X). The outermost protective layer (Y) can be covered, and the protection will dissolve in saliva first The innermost adhesive layer (X), and through the outermost protective layer (Y), the transmission and diffusion of the medicinal ingredients (xa) in the innermost adhesive layer (X) to the teeth, etc. change with time. In addition, the outermost protective layer (Y) can be easily removed by brushing with a toothbrush after the medicinal ingredient (xa) has worked.

Here, water insolubility refers to components that dissolve less than 0.1 g in 100 g of water at 25°C. Furthermore, in the outermost protective layer (Y), in terms of effectively suppressing the production of fish eyes and imparting excellent transparency, the content of the surfactant is more than 100% by mass in the outermost protective layer (Y). It is preferably less than 0.1% by mass, and more preferably less than 0.01% by mass, and it is particularly preferable that the outermost protective layer (Y) does not contain a surfactant.

Examples of the water-insoluble polymer (ya) include those selected from ethyl cellulose, hydroxypropyl methyl cellulose acetate succinate, cellulose acetate phthalate, and hypromellose phthalate. , Shellac, polyvinyl acetate, polymethyl methacrylate, methacryloyl ethyl betaine/methacrylate copolymer, methacrylic acid copolymer, aminoalkyl methacrylate copolymer and One or more of agar. Among them, from the viewpoint of preventing the appearance of the cloudy part in the outermost protective layer (Y) and imparting excellent transparency, preferably one or two selected from ethyl cellulose and shellac, more preferably Ethyl cellulose.

From the viewpoint of effectively suppressing the production of fish eyes in the outermost protective layer (Y) and imparting excellent transparency, the content of propylene glycol (yb) and glycerin (yc) and the content of water-insoluble polymer (ya) The mass ratio (((yb)＋(yc))/(ya)), that is, the total content of component (yb) and component (yc), and the mass ratio of the content of component (ya) (((yb)+ (yc))/(ya)) is preferably 0.1 or more, more preferably 0.25 or more, still more preferably 0.43 or more, preferably 9 or less, more preferably 4 or less, and still more preferably 2.3 or less. In addition, the total content of the component (yb) and the component (yc), and the mass ratio of the content of the component (ya) (((yb) + (yc))/(ya)) are preferably 0.1-9, more preferably 0.25 to 4, more preferably 0.43 to 2.3. In addition, the mass ratio ((yb)/(ya)) of the content of propylene glycol (yb) to the content of the water-insoluble polymer (ya) is preferably 0.1-9, more preferably 0.25-4, and still more preferably 0.43- 2.3.

The mass ratio of the content of propylene glycol (yb) to the total content of propylene glycol (yb) and glycerin (yc) ((yb)/((yb)+(yc))) is greater than 0.5, preferably greater than 0.7, and more preferably Is greater than 0.9. The upper limit of the mass ratio (yb)/((yb)+(yc)) may be 1 or less.

From the viewpoint of also ensuring good formability of the outermost protective layer (Y) and disintegration caused by brushing, the total content of one or more of ingredients (yb) and (yc) is In 100% by mass of the outermost protective layer (Y), it is preferably 7 mass% or more, more preferably 20 mass% or more, still more preferably 40 mass% or more, and preferably 90 mass% or less, more preferably 80 mass% % Or less, more preferably 70% by mass or less.

In addition to the above-mentioned components, the outermost protective layer (Y) may contain, for example, preservatives, pigments, etc., as components other than the above-mentioned components within a range that does not impair the effects of the present invention.

It effectively prevents the innermost adhesive layer (X) from dissolving saliva from being unnecessarily hindered by saliva or the tongue, and promotes the innermost adhesive layer (X) to dissolve saliva and the medicinal ingredients (xa) to teeth, etc. From the viewpoint of good transfer and diffusion, the thickness of the outermost protective layer (Y) is preferably 0.1 μm or more, more preferably 0.2 μm or more, and still more preferably 0.3 μm or more. In addition, from the viewpoint of ensuring higher transparency to the outermost protective layer (Y), and the viewpoint that it is less likely to cause discomfort even when the mouth is closed during application, the thickness of the outermost protective layer (Y) is preferably 5 μm Hereinafter, it is more preferably 3 μm or less, and still more preferably 2.5 μm or less. In addition, the thickness of the outermost protective layer (Y) is preferably 0.1-5 μm, more preferably 0.2-3 μm, and still more preferably 0.3-2.5 μm.

From the viewpoint of being effectively covered and protected by the outermost protective layer (Y) during the period when the medicinal ingredient (xa) is well transferred and spreading to teeth, etc., and from the viewpoint of being completely dissolved in saliva in a moderate time, The thickness of the innermost attachment layer (X) is preferably 9.9 to 95 μm, more preferably 19.8 to 87 μm, and still more preferably 29.7 to 77.5 μm or less.

In addition to the above-mentioned innermost adhesive layer (X) and outermost protective layer (Y), the dental patch of the present invention may be further provided between the innermost adhesive layer (X) and the outermost protective layer (Y). The formed middle layer (Z). Thereby, during use, the innermost adhesive layer (X) is dissolved in saliva to release the medicinal ingredient (xa) into the oral cavity, and then the middle layer (Z) is dissolved in the saliva and the medicinal ingredient (xa- 2) Is released into the oral cavity. (xa-2) is a component different from the medicinal component (xa) contained in the innermost adhesive layer (X), which can be selected from phytic acid, pyrophosphate, tripolyphosphate, glycyrrhizic acid, glycyrrhetinic acid and These salts, and one or more of potassium nitrate and fluorine. By providing the intermediate layer (Z), it is easy to give stepwise solubility, that is, the intermediate layer (Z) is dissolved after the innermost adhesive layer (X) is dissolved. As the material of the intermediate layer (Z), one or two selected from pullulan, hydroxyethyl cellulose, guar gum, hydroxypropyl cellulose, hypromellose, gelatin, and agar can be cited the above.

From the viewpoint of ensuring the softness suitable for attachment or the followability to teeth, etc., and the viewpoint of ensuring that the medicinal ingredient (xa) acts on the teeth and the amount required to guide it to a good state, the dental use of the present invention The total thickness of the patch is preferably 100-10 μm, more preferably 90-20 μm, and still more preferably 80-30 μm or less.

In order to manufacture the dental patch of the present invention, a single-layer sheet including the innermost attachment layer (X), a single-layer sheet including the outermost protective layer (Y), and a single-layer sheet including the outermost protective layer (Y) can be formed separately. After the single-layer sheet of the intermediate layer (Z), the sheets are laminated, and the layers can also be laminated on the substrate in sequence. The innermost adhesive layer (X) uses the original solution (X), the outermost protective layer (Y) uses the original solution (Y), and the middle layer (Z) also uses the original solution. Then the original solutions are made into layers, Through the drying step, the dental patch of the present invention can be formed thereby. Furthermore, the stock solution (X) used to form the innermost adhesive layer (X) only needs to contain the medicinal component (xa) in the above-mentioned specific amount, and in addition, it may be prepared by appropriately containing components such as water. The undiluted solution (Y) forming the outermost protective layer (Y) may be prepared by containing the water-insoluble polymer (ya) and propylene glycol (yb) so as to achieve the above-mentioned specific mass ratio, and appropriately containing components such as water. The stock solution used to form the intermediate layer (Z) can also be prepared in the same manner.

Specifically, for example, in the case of forming a single-layer sheet including the innermost adhesive layer (X), after preparing the stock solution (X) containing the medicinal ingredient (xa), the thickness is considered, and the implementation Coating the stock solution (X) on a polyethylene terephthalate (PET) film such as mold release treatment and drying it. Then, by peeling off the PET film, sheets each containing a single layer can be obtained. Among them, the sheet constituting the side surface to be attached to the tooth or the like may be directly carried without peeling the PET film. Then, a PET film is placed on the lowermost layer, and the innermost adhesive layer (X), other intermediate layers (Z), and other intermediate layers (Z), including the innermost adhesive layer (X), other intermediate layers (Z), and the After the single-layer sheet of the outermost protective layer (Y), for example, a pressing device is used for crimping. Furthermore, the pressurizing device here may also perform heating. Thereafter, by peeling off the PET film of the lowermost layer, the dental patch of the present invention can be obtained.

In the case of sequential layering on a substrate, when the innermost adhesive layer (X) constitutes the surface for attaching to the tooth or the like, for example, first use a PET film as the substrate and apply the original solution (X ), it is dried to form the innermost adhesive layer (X). Secondly, after forming an intermediate layer (Z) on the innermost adhesive layer (X) as needed, apply the stock solution (Y) and dry it to form the outermost protective layer (Y), thereby obtaining the present invention Patches for teeth.

The dental patch of the present invention can bring the desired effect derived from the medicinal ingredient (xa) to the teeth of the attached body by being attached to the teeth. When attaching a dental patch to teeth, etc., the time from immediately after attaching to when the innermost attaching layer (X) is completely dissolved in saliva is preferably 3 minutes or more, more preferably 5 minutes or more, and then It is preferably 7 minutes or more, and preferably 60 minutes or less, more preferably 45 minutes or less, and still more preferably 30 minutes or less.

The dental patch of the present invention is formed by covering and protecting the innermost adhesive layer (X) that constitutes the attached surface when it is attached to a tooth or the like by the outermost protective layer (Y) with higher transparency. Therefore, at the part where the sheet is attached, the dissolution status of the layer arranged on the inner side of the outermost protective layer (Y) or the transfer of medicinal ingredients (xa) to the teeth can be visually recognized through the outermost protective layer (Y) , The spreading situation, and the appropriate time for attaching can also be clearly specified. Moreover, by applying a color or pattern to a layer arranged on the inner side of the outermost protective layer (Y), it is also possible to easily recognize changes over time through the outermost protective layer (Y). Furthermore, if the transparency of the innermost adhesive layer (X) is also improved, the dental patch of the present invention can also be visually assimilated to the teeth or the peripheral part of the teeth, thereby reducing the foreign body sensation. [Example]

Hereinafter, the present invention will be specifically described based on examples. In addition, unless otherwise indicated in the table, the content of each component is indicated by mass %.

[Examples 1 to 21, Comparative Examples 1 to 2] In order to obtain the innermost adhesive layer (X) shown in Table 1, purified water was used as a solvent and the components containing phytic acid as a medicinal component (xa) were mixed to prepare a stock solution (X). Similarly, in order to obtain the outermost protective layer (Y) shown in Table 1, ethanol was used as a solvent and a water-insoluble polymer (ya) and propylene glycol (yb) or glycerin (yc) were mixed to prepare a stock solution (Y) . Then, while considering the thickness, the obtained dope (X) is coated on a polyethylene terephthalate (PET) film and dried to obtain the innermost adhesive layer (X). Then, the stock solution (Y) is applied on the innermost adhesive layer (X) and dried to obtain the outermost protective layer (Y) 1～2 μm on the innermost adhesive layer (X) 60～70 μm The total thickness of the dental patch is 61-72 μm. Furthermore, the values shown in Table 1 constitute the values of the innermost attachment layer (X) and the outermost protective layer (Y) of the dental patch after drying.

"Evaluation of the transparency of the outermost protective layer (Y) and the overall transparency of the dental patch" Regarding the transparency of the outermost protective layer (Y), the presence or absence of turbidity in the outermost protective layer (Y) was used as an index for evaluation. Specifically, the obtained tooth patch was placed on black paper, and the presence or absence of white turbidity was judged by visual inspection and the following five-stage evaluation. The results are shown in Table 1. 1: There is no cloudy part at all, so black can be recognized immediately 2: No turbidity area (cannot be recognized as a turbidity area), black can be recognized 3: Although there is a little cloudy part (about 1/4 or less), black can be recognized 4: There is quite a cloudy part (about 1/2), and a part of black cannot be recognized 5: The turbidity part exists throughout the whole (about 3/4 or more), and black cannot be recognized

In addition, regarding the overall transparency of the dental patch, whether characters can be recognized through the sheet is used as an evaluation index. Specifically, the tooth patch is placed at a certain distance from the paper on which the characters are printed, and it is determined whether the characters can be recognized through the sheet by visual observation based on the following judgment criteria. The results are shown in Table 2. 1: Because of the transparency, the text can be recognized immediately 2: Although the transparency is slightly low, but can fully recognize the text 3: Transparency is somewhat low, but it can barely recognize text 4: Transparency is quite lacking, barely able to identify the text itself 5: Transparency is completely lacking and it is difficult to identify the text itself

[Table 1] Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Example 8 Example 9 Example 10 Example 11 Example 12 Example 13 Example 14 Example 15 Example 16 Example 17 Example 18 Example 19 Example 20 Example 21 Comparative example 1 Comparative example 2 (X) Innermost attachment layer (xa) Phytic Acid 13.82 13.82 13.82 13.82 13.82 13.82 13.82 13.82 13.82 10.00 15.00 12.50 12.50 12.50 12.50 12.50 12.50 - - 12.50 12.50 13.82 13.82 Sodium fluoride - - - - - - - - - - - - - - - - - 0.32 0.32 - - - - Potassium nitrate - - - - - - - - - - - - - - - - - 5.00 - - - - - Sodium hydroxide 3.80 3.80 3.80 3.80 3.80 3.80 3.80 3.80 3.80 4.50 6.80 5.70 - 5.70 5.70 5.70 - - 5.70 5.70 3.80 3.80 Potassium hydroxide - - - - - - - - - - - - 5.70 5.70 - - - - - - - - - Propylene Glycol - - - - - - - - - - - - - - - - - 10.23 10.23 - - - - (xd) Amylopectin 50.0 50.0 50.0 50.0 50.0 50.0 50.0 50.0 50.0 53.8 46.5 50.1 50.1 35.1 35.1 50.0 50.0 52.8 57.8 50.1 50.1 50.0 50.0 Hydroxypropylmethylcellulose - - - - - - - - - - - - - 15.1 - - - - - - - - - Agar - - - - - - - - - - - - - - 15.1 - - - - - - - - glycerin 18.3 18.3 18.3 17.5 18.3 15.0 17.5 16.0 15.0 17.3 17.3 17.3 17.3 17.3 17.3 17.3 17.3 17.3 17.3 17.3 17.3 18.3 18.3 (xb-1) Polyoxyethylene hydrogenated castor oil ^{※ 1} 2.5 2.5 2.5 4.0 2.5 5.1 0.0 0.0 0.0 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 (xb-2) Polyglycerol myristic acid ^{* 2} 1.3 1.3 1.3 0.5 1.3 0.0 2.5 1.0 0.0 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 (xc) spices 0.7 0.7 0.7 0.7 0.7 0.7 0.7 0.7 0.7 0.7 0.7 0.7 0.7 0.7 0.7 0.7 0.7 0.7 0.7 0.7 0.7 0.7 0.7 pigment 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 water margin margin margin margin margin margin margin margin margin margin margin margin margin margin margin margin margin margin margin margin margin margin margin total 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 (Y) Outermost protective layer (ya) Ethyl cellulose 50 70 90 50 50 50 50 50 50 50 50 50 50 50 50 - - 50 50 50 70 50 70 shellac - - - - - - - - - - - - - - - 50 70 - - - - (yb) Propylene Glycol 50 30 10 50 - 50 50 50 50 50 50 50 50 50 50 50 30 50 50 36 twenty two - - (yc) glycerin - - - - 50 - - - - - - - - - - - - - - 14 8 - - Polyethylene glycol - - - - - - - - - - - - - - - - - - - - 50 30 total 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 (xb-1)/(xb-2) 2.0 2.0 2.0 8.0 2.0 - - - - - - - - - - 2.0 2.0 - - - - 2.0 2.0 (xb-1)＋(xb-2) 3.8 3.8 3.8 4.5 3.8 5.1 2.5 1.0 0 0 0 0 0 0 0 3.8 3.8 0 0 0 0 3.8 3.8 (yb)/(yb)＋(yc)) 1 1 1 1 - 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0.7 0.7 - - Transparency of the outermost protective layer 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 3 5 5 ※1Polyoxyethylene hydrogenated castor oil (the average number of moles of ethoxylate added is 40) ※2 Polyglycerol myristic acid (average degree of condensation of glycerol 10)

[Table 2] Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Example 15 Comparative example 1 Comparative example 2 Transparency of the whole sheet 1 1 1 1 4 3 4 2 5 5

Claims (8)

A dental patch, which is formed by laminating the innermost adhesive layer (X) and the outermost protective layer (Y), The innermost adhesive layer (X) has adhesion to teeth and solubility in water, and contains medicinal ingredients (xa); The outermost protective layer (Y) is a layer whose adhesion to teeth and water solubility are lower than that of the innermost adhesive layer (X), and contains a water-insoluble polymer (ya), and contains selected from propylene glycol (yb) And one or two of glycerin (yc). Such as the tooth patch of claim 1, wherein the innermost adhesive layer (X) further contains a nonionic surfactant (xb), and The content of the component (xb) in 100% by mass of the innermost adhesive layer (X) is 2% by mass to 6% by mass. Such as the dental patch of claim 2, wherein the component (xb) contains at least polyoxyethylene hydrogenated castor oil (xb-1) and polyglycerin fatty acid ester (xb-2), and The mass ratio ((xb-1)/(xb-2)) of the content of the component (xb-1) in the innermost adhesive layer (X) to the content of the component (xb-2) is 0.1 or more and 10 or less. The dental patch of claim 1 or 2, wherein the component (ya) is selected from ethyl cellulose, hydroxypropyl methyl cellulose acetate succinate, cellulose acetate phthalate, and hypromellose Phthalates, shellac, polyvinyl acetate, polymethyl methacrylate, methacrylic ethyl betaine/methacrylate copolymer, methacrylic acid copolymer, methacrylic amine group One or more of alkyl ester copolymer and agar. For example, the tooth patch of claim 1 or 2, wherein the thickness of the outermost protective layer (Y) is 0.1 μm to 5 μm. For example, the dental patch of claim 1 or 2, wherein the innermost adhesive layer (X) further contains fragrance (xc). For the dental patch of claim 1 or 2, wherein the innermost adhesive layer (X) contains selected from pullulan, hydroxyethyl cellulose, guar gum, hydroxypropyl cellulose, hypromellose, One or more water-soluble polymers of gelatin and agar (xd). Such as the tooth patch of claim 1 or 2, the content of ingredient (yb) and the mass ratio of the total content of ingredient (yb) and ingredient (yc) ((yb)/((yb) + (yc)) ) Is greater than 0.5.