TW202043250A - Ｔ細胞受體及其使用方法 - Google Patents

Ｔ細胞受體及其使用方法 Download PDF

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TW202043250A
TW202043250A TW109107115A TW109107115A TW202043250A TW 202043250 A TW202043250 A TW 202043250A TW 109107115 A TW109107115 A TW 109107115A TW 109107115 A TW109107115 A TW 109107115A TW 202043250 A TW202043250 A TW 202043250A
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hla
tcr
chain
amino acid
acid sequence
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TW109107115A
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平野直人
村田健司
佐蘇佳代子
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加拿大商大學健康網絡
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C12N9/6494—Neprilysin (3.4.24.11), i.e. enkephalinase or neutral-endopeptidase 24.11
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    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/57—Skin; melanoma
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TW109107115A 2019-03-04 2020-03-04 Ｔ細胞受體及其使用方法 TW202043250A (zh)

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US201962813645P 2019-03-04 2019-03-04
US62/813,645 2019-03-04

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US (1) US12522644B2 (https=)
EP (1) EP3935176A4 (https=)
JP (1) JP7727546B2 (https=)
KR (1) KR20210149048A (https=)
CN (1) CN113795584B (https=)
AU (1) AU2020231194A1 (https=)
BR (1) BR112021017505A2 (https=)
CA (1) CA3132431A1 (https=)
IL (1) IL286046A (https=)
MX (1) MX2021010541A (https=)
SG (1) SG11202109591QA (https=)
TW (1) TW202043250A (https=)
WO (1) WO2020178741A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
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JP7748284B2 (ja) 2019-03-04 2025-10-02 ユニバーシティー ヘルス ネットワーク Ｔ細胞受容体及びその使用方法
MX2021010541A (es) 2019-03-04 2021-12-15 Univ Health Network Receptores de linfocitos t y metodos de uso de estos.
CN113795586B (zh) 2019-03-25 2026-03-27 大学健康网络 T细胞受体及其使用方法
WO2025096983A1 (en) * 2023-11-02 2025-05-08 Board Of Regents, The University Of Texas System Peptides and engineered t cell receptors targeting tpx2 antigen and methods of use

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1064022A4 (en) 1998-03-13 2004-09-29 Epimmune Inc HLA BINDING PROTEINS AND THEIR USE
ATE395930T1 (de) * 1999-10-22 2008-06-15 Aventis Pasteur Verfahren zur erregung und/oder verstärkung der immunantwort gegen tumorantigene
US6506875B1 (en) 2000-09-26 2003-01-14 Ludwig Institute For Cancer Research Isolated peptides which bind to HLA-C molecules and uses thereof
CN101175853A (zh) 2005-03-16 2008-05-07 Dna吉诺特克股份有限公司 用于保存来自体液的核酸的组合物和方法
AU2008206442B2 (en) 2007-01-12 2012-10-18 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services gp100-specific T cell receptors and related materials and methods of use
JP5292550B2 (ja) 2007-03-23 2013-09-18 静岡県 Ｔ細胞レセプターβ鎖遺伝子及びα鎖遺伝子
CA2682093A1 (en) 2007-03-29 2008-10-09 Technion Research & Development Foundation Ltd. Antibodies, methods and kits for diagnosing and treating melanoma
US9051391B2 (en) * 2007-06-11 2015-06-09 Takara Bio Inc. Method for expression of specific gene
WO2010037395A2 (en) * 2008-10-01 2010-04-08 Dako Denmark A/S Mhc multimers in cancer vaccines and immune monitoring
PT2413956T (pt) 2009-04-02 2016-12-30 Vaxon Biotech Identificação, optimização e utilização de epitopos crípticos hla-a24 para imunoterapia
WO2011140284A2 (en) 2010-05-04 2011-11-10 Fred Hutchinson Cancer Research Center Conditional superagonist ctl ligands for the promotion of tumor-specific ctl responses
ES2635335T3 (es) 2010-09-20 2017-10-03 Biontech Cell & Gene Therapies Gmbh Receptores de células T específicos de antígeno y epítopos de células T
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
WO2014207708A2 (en) 2013-06-28 2014-12-31 Auckland Uniservices Limited Amino acid and peptide conjugates and conjugation process
KR101503341B1 (ko) 2014-03-12 2015-03-18 국립암센터 자가암항원 특이적 cd8+ t 세포의 분리 및 증식방법
EP3155426B1 (en) * 2014-06-13 2023-07-19 Immudex ApS General detection and isolation of specific cells by binding of labeled molecules
AU2015343013B2 (en) 2014-11-05 2020-07-16 Board Of Regents, The University Of Texas System Gene modified immune effector cells and engineered cells for expansion of immune effector cells
NL2014935B1 (en) 2015-06-08 2017-02-03 Applied Immune Tech Ltd T cell receptor like antibodies having fine specificity.
WO2017120428A2 (en) 2016-01-06 2017-07-13 Health Research, Inc. Compositions and libraries comprising recombinant t-cell receptors and methods of using recombinant t-cell receptors
US11396536B2 (en) 2016-04-27 2022-07-26 University Health Network Peptide-HLA complexes and methods of producing same
EP3935171A4 (en) 2019-03-04 2022-12-28 University Health Network T-CELL RECEPTORS AND METHODS OF USE THEREOF
JP7748284B2 (ja) 2019-03-04 2025-10-02 ユニバーシティー ヘルス ネットワーク Ｔ細胞受容体及びその使用方法
CN113795585B (zh) 2019-03-04 2026-03-06 大学健康网络 T细胞受体及其使用方法
WO2020178738A1 (en) 2019-03-04 2020-09-10 University Health Network T cell receptors and methods of use thereof
AU2020231927A1 (en) 2019-03-04 2021-09-30 University Health Network T cell receptors and methods of use thereof
MX2021010541A (es) 2019-03-04 2021-12-15 Univ Health Network Receptores de linfocitos t y metodos de uso de estos.
CN113795586B (zh) 2019-03-25 2026-03-27 大学健康网络 T细胞受体及其使用方法

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CN113795584A (zh) 2021-12-14
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BR112021017505A2 (pt) 2021-11-23
EP3935176A1 (en) 2022-01-12
CN113795584B (zh) 2025-09-30
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