TW202029975A - Composition for restoring the skin barrier and use thereof - Google Patents

Abstract

A composition for restoring the skin barrier is provided. The composition includes a Ganoderma extract and an ion regulator, wherein the ion regulator comprises calcium ion, magnesium ion, sodium, potassium ion and chloride ion. A use of the composition is also provided. The composition is for the manufacture of a medicament for the treatment of skin disease, or skin discomfort or abnormal symptoms caused by disease.

Description

Composition for repairing skin barrier and its use

The present invention relates to a skin barrier repair composition and its use, and more particularly to a skin barrier repair composition with a Ganoderma lucidum extract and an ion regulator and its use.

The skin is currently the largest organ of the human body. The importance of the skin is to isolate the moisture-rich internal organs from the external dry environment. The skin has a barrier function. The barrier function is provided by the stratum corneum (about 10 to 20 microns in humans) located in the uppermost layer of the skin. The normal skin barrier function can prevent external stimuli from invading the skin and the skin moisture is not easily lost.

The stratum corneum (stratum corneum) is the outermost layer of the skin epidermis, which is mainly composed of 15 to 20 layers of dead cells without nuclei. When these cells fall off, the underlying cells in the basal layer will be pushed up to form a new stratum corneum. The stratum corneum is composed of two components: protein-rich inactive keratinocytes and an intercellular matrix composed of lipids. With keratinocytes and lipids The combination of, forms a specific "brick and mud" structure, making the stratum corneum exhibit a high degree of impermeability.

The ion concentration in the skin plays an important role in the function of the barrier. Calcium ions are an important messenger in the cell's message transmission system. Most cells have special receptors that accept calcium ions. In the skin, calcium ions can provide intracellular or extracellular signals to cells. It has been found that the intracellular calcium ion concentration increases with the increase of the extracellular calcium ion concentration, and the increase of intracellular calcium ion is a signal to stimulate the differentiation of keratinocytes. In keratinocytes, the extracellular content and the intracellular concentration usually maintain a balance. In addition, calcium ions participate in the differentiation of keratinocytes and also help keratinocytes to secrete lipids.

In normal skin, calcium ions are confined to the epidermal granular layer below the stratum corneum at high concentrations, and there is a calcium ion concentration gradient in the epidermal layer. The calcium ion content of the upper epidermis is higher than that of the lower epidermis, that is, it steadily increases from the basal layer area to the stratum corneum, forming an inverted trapezoidal concentration distribution, while other ions do not. However, when the skin is under pathological conditions, the calcium ion concentration distribution in the epidermal layer will change, that is, the calcium ion concentration gradient is no longer in an inverted trapezoidal distribution as in healthy skin.

Ganoderma Extract can promote cell regeneration and help wound healing. Ganoderma lucidum extract recovers wounds through the following four mechanisms: (1) Ganoderma lucidum extract can significantly promote the proliferation of fibroblast cells and keratinocytes, while increasing the ability of fibroblast migration to accelerate wound healing. Efficacy; (2) Ganoderma lucidum extract can effectively reduce the activity of matrix metalloproteinase (Matrix metalloproteinase) MMP-9, reduce the excessive decomposition of the cell matrix of the tissue around the wound, and achieve the effect of helping tissue reconstruction and shortening the inflammation period of the wound; (3) Ganoderma lucidum extract can effectively inhibit the activity of proteases (proteases), causing bacteria to die due to the inability to obtain nutrients; by inhibiting the growth of bacteria on the skin surface, it can achieve the natural anti-inflammatory effect; (4) Ganoderma cell wall extract is mainly composed of 50-60 Consisting of% polysaccharides and 40-50% chitin, these two components are known to have excellent moisturizing activity and can provide a moisturizing environment required for wound healing, thereby accelerating wound healing.

However, if Ganoderma lucidum extract is used alone, although it can promote skin keratinocyte proliferation and restore wound healing, it cannot restore the inverted trapezoidal distribution of calcium ion concentration gradient in healthy skin, resulting in the skin barrier still not functioning normally. If the external stimulus invades skin cells, water is easily lost, and the cells are prone to inflammation after being stimulated.

In view of this, how to develop a composition that promotes the proliferation of skin keratinocytes and restores the inverted trapezoidal distribution of the calcium ion concentration gradient in the skin to repair the skin barrier, the existing technology needs to be improved.

The purpose of the present invention is to provide a composition for repairing the skin barrier, in addition to promoting the proliferation of skin keratinocytes, and providing an appropriate ion environment in the skin, so as to restore the inverted trapezoidal distribution of calcium ion concentration gradient in the skin and restore the skin The effectiveness of the barrier.

The present invention provides a composition for repairing the skin barrier, comprising: Ganoderma lucidum extract; and an ion regulator, comprising calcium ions, magnesium ions, and sodium Ions, potassium ions and chloride ions, where the total weight of the composition is 100%, the weight percentage of Ganoderma lucidum extract is 0.00000072% to 0.11%, the weight percentage of calcium ions is 0.0001244% to 0.04998%, and the weight percentage of magnesium ions is 0.0000412% to 0.03157%, the weight percentage of sodium ions is 0.0002133% to 0.09114%, the weight percentage of potassium ions is 0.0000875% to 0.03301%, and the weight percentage of chloride ions is 0.0004754% to 0.16639%.

In some embodiments, the Ganoderma lucidum extract comprises a copolymer of dextran and amino glucose, the dextran comprises α-glucan, β-glucan or a combination thereof, and the amino glucose comprises N-acetylglucosamine ( N- Acetylglucosamine, GlcNAc), N-Acetylmuramic acid (MurNAc) or a combination thereof.

In some embodiments, the Ganoderma lucidum extract comprises micron-grade Ganoderma lucidum extract or nano-grade Ganoderma lucidum extract, wherein the weight percentage of the micron-grade Ganoderma lucidum extract is 0.0000072% to 0.088%, and the weight percentage of the nano-grade Ganoderma lucidum extract The weight percentage is 0.00018% to 0.11%.

In some embodiments, the composition further contains lipids, and the weight percentage of lipids is 0.001% to 40%.

In some embodiments, the composition further contains lipids, and the weight percentage of lipids is 0.001% to 15%.

In some embodiments, the lipid comprises ceramide, glyceride, cholesterol, free fatty acid, or a combination thereof.

In some embodiments, ceramide comprises ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6, ceramide 7, ceramide 8, Ceramide 9, or a combination thereof.

In some embodiments, the composition is used to treat skin diseases or to improve skin discomfort or abnormal symptoms caused by diseases. Skin diseases include atopic dermatitis, seborrhoeic dermatitis, Contact dermatitis, lupus erythematosus, lichen planus, urticaria, keratosis, acne, psoriasis, or fish scales Disease (ichthyosis).

In some embodiments, the composition is in the form of a liquid, essence, lotion, makeup remover product, facial mask, wipe product, lotion, cream, ointment, or gel. Among them, the liquid agent may be, for example, a lotion.

In some embodiments, the composition further includes a cosmetically acceptable carrier.

In some embodiments, the cosmetically acceptable carrier includes solvents, emollients, humectants, emulsifiers, thickeners, antioxidants, preservatives, or combinations thereof.

In some embodiments, the weight percentage of the emollient is 7% to 22%; the weight percentage of the humectant is 4% to 12%; the weight percentage of the emulsifier is 2% to 6.5%; the weight percentage of the thickener is 0.3% to 1%; the weight percentage of antioxidants is 0.2% to 0.8%; and the weight percentage of preservatives is 0.0004% to 0.002%.

In some embodiments, the weight percentage of the emollient is 2% to 30%; the weight percentage of the humectant is 0.1% to 20%; the weight percentage of the emulsifier is 0.1% to 10%; the weight percentage of the thickener is 0.1% to 5%; the weight percentage of antioxidants is 0.01% to 5%; and the weight percentage of preservatives is 0.0004% to 5%.

In some embodiments, the composition further includes a pharmaceutically acceptable carrier.

The present invention also provides the use of a composition for preparing a preparation for treating skin diseases or improving skin discomfort or abnormal symptoms caused by diseases, wherein the composition is as described above.

In some embodiments, the skin disease includes atopic dermatitis, seborrheic dermatitis, contact dermatitis, lupus erythematosus, lichen planus, urticaria, keratosis, acne, psoriasis, or ichthyosis.

The present invention also provides the use of a composition for preparing a preparation for treating skin diseases or improving skin discomfort or abnormal symptoms caused by diseases, wherein the composition is as described above, and the administration of the composition is daily At least once.

In some embodiments, the recovery rate of skin disease or skin discomfort or abnormal symptoms caused by the disease is increased by 10% or more compared with the control group when the composition is administered for two days.

As mentioned above, in the composition of the present invention, the Ganoderma lucidum extract in the composition promotes cell regeneration and accelerates the proliferation of skin keratinocytes. Then use the ion combination of a specific ratio in the ion regulator to restore the inverted trapezoidal distribution of the calcium ion concentration gradient in the skin epidermis to provide suitable keratinocyte growth surroundings. Finally, a specific ratio of ion combinations can sustainably maintain the inverted trapezoidal distribution of calcium ion concentration gradient in the skin barrier layer to maintain the function of the new skin barrier. Repairing the skin barrier by the composition of the present invention can prevent external stimuli from invading the skin and loss of skin moisture, and avoid the uncomfortable feeling of swelling and hot spurs caused by inflammation after the skin is exposed to external stimuli. Secondly, the composition of the present invention can also be used on the skin under pathological conditions to treat or improve skin discomfort or abnormal symptoms by repairing the skin barrier, including skin itching symptoms of dialysis patients.

In order to make the above and other objectives, features, advantages and embodiments of the present invention more comprehensible, the description of the accompanying drawings is as follows:

Figure 1 shows a bar graph of the percutaneous water loss of each group on the second day in an embodiment of the present disclosure.

Figure 2 is a histogram of the recovery rate on the second day of each group in an embodiment of the present disclosure.

In order to make the description of the present invention more detailed and complete, the following describes the embodiments and specific examples of the present invention in detail; but this is not the only way to implement or use the specific embodiments of the present invention. The embodiments disclosed below can be combined or substituted with each other under beneficial circumstances, and other embodiments can also be added to an embodiment without further description or description.

The words "include", "include", "have" and similar words used in this text indicate the recorded features, regions, integers, steps, operations, elements and/or components, but do not exclude other features and regions , Integers, steps, operations, elements, components, and/or groups thereof.

The present invention provides a composition for repairing the skin barrier comprising: Ganoderma lucidum extract and an ion regulator; the ion regulator includes calcium ion, magnesium ion, sodium ion, potassium ion and chloride ion.

In some embodiments, the Ganoderma lucidum extract comprises a copolymer of dextran and amino glucose, the dextran comprises α-glucan, β-glucan or a combination thereof, and the amino glucose comprises N-acetylglucosamine , N-acetylmuramic acid or a combination thereof. In some embodiments, the α-glucan comprises α-1,4-glucan, α-1,6-glucan or a combination thereof, and the β-glucan comprises β-1,3-D-glucan. Glycan, β-1,4-D-glucan, β-1,6-D-glucan, or a combination thereof.

In some embodiments, the total weight of the composition is based on 100%, the weight percentage of the Ganoderma lucidum extract is 0.0000072% to 0.11%, the weight percentage of calcium ions is 0.0001244% to 0.04998%, and the weight percentage of magnesium ions is 0.0000412% to 0.0000412%. 0.03157%, the weight percentage of sodium ion is 0.0002133% to 0.09114%, the weight percentage of potassium ion is 0.0000875% to 0.03301%, and the weight percentage of chloride ion is 0.0004754% to 0.16639%.

In one embodiment, the Ganoderma lucidum extract is a Ganoderma lucidum cell wall extract. Ganoderma includes fungi of the genus Ganoderma, such as Ganoderma lucidum or Ganoderma Tsugae . The Ganoderma lucidum extract can be micron grade Ganoderma lucidum extract or nanometer grade Ganoderma lucidum extract depending on its fiber size. In some embodiments, the total weight of the composition is based on 100%, and the weight percentage of the micron grade Ganoderma lucidum extract may be 0.00000072% to 0.088%. In some embodiments, the total weight of the composition is 100%, and the weight percentage of the nano-grade Ganoderma lucidum extract is 0.00018% to 0.11%.

In one embodiment, the weight percentage of Ganoderma lucidum extract is 0.02%, the weight percentage of calcium ions is 0.0469%, the weight percentage of magnesium ions is 0.02296%, the weight percentage of sodium ions is 0.08225%, and the weight percentage of potassium ions is 0.0315. %, and the weight percentage of chloride ion is 0.16639%.

In some embodiments, the composition for repairing the skin barrier is in the form of a liquid, an essence, a lotion, a makeup remover, a mask, a wipe product, an emulsion, a cream, an ointment, or a gel.

In some embodiments, the composition for repairing the skin barrier further comprises a cosmetically acceptable carrier, and the carrier comprises a solvent, an emollient, a moisturizer, an emulsifier, a thickener, an antioxidant, a preservative, or a combination thereof .

In one embodiment, the solvent includes, but is not limited to water.

In some embodiments, the total weight of the composition is 100%, and the weight percentage of the emollient is 7% to 22%.

In some embodiments, the total weight of the composition is 100%, and the weight percentage of the emollient is 2% to 30%. In one embodiment, the emollient includes, but is not limited to Caprylic Triglyceride, Capric Triglyceride, Isononyl Isononyl Isononanoate), polybutene (Polybutene), Cyclopentasiloxane (Cyclopentasiloxane), Dodecene (Dodecene), or a combination thereof.

In some embodiments, the total weight of the composition is 100%, and the weight percentage of the humectant is 4% to 12%.

In some embodiments, the total weight of the composition is based on 100%, and the weight percentage of the humectant is 0.1% to 20%. In one embodiment, the moisturizer includes, but is not limited to, glycerin (Glycerin), 1,2-hexanediol (1,2-Hexanediol), mannitol (Mannitol), 1,3-propanediol (Propanediol), ethane Ethylhexylglycerin or a combination thereof.

In some embodiments, the total weight of the composition is 100%, and the weight percentage of the emulsifier is 2% to 6.5%.

In some embodiments, the total weight of the composition is based on 100%, and the weight percentage of the emulsifier is 0.1% to 10%. In one embodiment, the emulsifier includes, but is not limited to, lauryl polymethicone (for example, lauryl PEG/PPG-18/18 polymethylsiloxane Lauryl PEG/PPG-18/18 Methicone), Isostearyl Alcohol, Sodium Lauroyl Lactylate, or a combination thereof.

In some embodiments, the total weight of the composition is 100%, and the weight percentage of the thickener is 0.3% to 1%.

In some embodiments, the total weight of the composition is 100%, and the weight percentage of the thickener is 0.1% to 5%. In one embodiment, increasing Thickeners include, but are not limited to, Hydroxyethylcellulose, Dimethicone Crosspolymer, Xanthan Gum, Carbomer, or a combination thereof .

In some embodiments, the total weight of the composition is 100%, and the weight percentage of the antioxidant is 0.2% to 0.8%.

In some embodiments, the total weight of the composition is 100%, and the weight percentage of the antioxidant is 0.01% to 5%. In one embodiment, the antioxidant includes, but is not limited to, Hydroxyacetophenone or Tocopheryl Acetate.

In some embodiments, the total weight of the composition is 100%, and the weight percentage of the preservative is 0.0004% to 0.002%.

In some embodiments, the total weight of the composition is 100%, and the weight percentage of the preservative is 0.0004% to 5%. In one embodiment, the preservative includes, but is not limited to, Phenoxyethanol.

In some embodiments, the composition for repairing the skin barrier further includes a pharmaceutically acceptable carrier.

The present invention also provides a use of a composition for repairing the skin barrier, which is used to prepare a preparation for treating skin diseases or improving skin discomfort or abnormal symptoms caused by diseases.

In some embodiments, the skin disease includes atopic dermatitis, seborrheic dermatitis, contact dermatitis, lupus erythematosus, lichen planus, urticaria, keratosis, acne, psoriasis, or ichthyosis.

The present invention also provides a use of a composition for repairing skin barrier, which is used to prepare a preparation for treating skin diseases or improving skin discomfort or abnormal symptoms caused by diseases, wherein the composition is administered at least once a day. In some embodiments, the composition is administered once, twice, three times, or four times daily.

In some embodiments, the recovery rate of skin disease or skin discomfort or abnormal symptoms caused by the disease is increased by 10% or more compared with the control group when the composition is administered for two days. In one embodiment, the recovery rate is increased by 10-50% compared to the control group, for example, 11%, 12%, 13%, 15%, 20%, 25%, 30%, or 40%.

In a specific embodiment, the composition for repairing the skin barrier is prepared according to the ratio of ingredients listed in Table 1:

In some embodiments, the composition for repairing the skin barrier further comprises lipids. The total weight of the composition is 100%, and the weight percentage of lipids is 0.001% to 40%. In other embodiments, the weight percentage of lipids is 0.001% to 15%. In one embodiment, the lipid comprises ceramide, glyceride, cholesterol, free fatty acid, or a combination thereof. In some embodiments, ceramide comprises ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6, ceramide 6, ceramide 8, ceramide 8, Ceramide 9, or a combination thereof. In one embodiment, ceramide includes ceramide 1, ceramide 3, and ceramide 6II.

Ceramide is the main component of the intercellular matrix of the stratum corneum of human skin. The intercellular matrix of the stratum corneum is mainly composed of lipids, namely the mud in the "brick and mud" structure. Lipids are composed of about 50% ceramide, about 25% cholesterol and about 15% free fatty acids. Cholesterol and free fatty acids together produce an impermeable protective structure to prevent excessive evaporation of water while also preventing the entry of microorganisms and external stimuli.

In another specific embodiment, the composition for repairing the skin barrier is prepared according to the ratio of ingredients listed in Table 2:

The skin barrier repair composition of the present invention can be used to treat skin diseases or improve skin discomfort or abnormal symptoms caused by diseases. The skin disease may be, for example, atopic dermatitis, seborrheic dermatitis, contact dermatitis, lupus erythematosus, lichen planus, urticaria, keratosis, acne, psoriasis, or ichthyosis. The skin discomfort or abnormal symptoms caused by the disease can be, for example, inflammatory reactions such as dry skin, itching, peeling, redness, swelling and tingling caused by skin diseases or other diseases.

Dialysis patients often experience itching all over the body, which is called "uremic pruritus". Symptoms of uremic pruritus are usually systemic, most often on the back (50%), face (30%), upper limbs (10%) and lower limbs (5%). The possible causes of uremic pruritus are: (1) hyperparathyroidism; (2) changes in the metabolism of divalent ions, such as high blood calcium or magnesium, and large amounts of divalent cations may be deposited in the dermis as a source of stimulation; (3) Central neurogenic itching may be derived from the opioid nervous system; (4) Peripheral neuropathy, an increase in nerve fibers observed from epidermal slices of patients with uremia may be related to skin itching; ( 5) Abnormal secretion of sebaceous glands or decreased sweat secretion, resulting in dry skin; (6) Hypervitaminosis A, which makes the skin drier and easier to peel; (7) Mast cells proliferate or are easily stimulated to release histamine. In some embodiments, the composition for repairing the skin barrier of the present invention can be used to improve skin discomfort or abnormal symptoms caused by uremic pruritus.

The following experimental examples will illustrate the effect of the skin barrier repair composition of the present invention in repairing the skin barrier.

Repair skin barrier test

Take a few nude mice (Nude mice) about 7 weeks old, weighing 20±2 grams, and eat and drink freely. The experiment is divided into 1 control group and 3 experimental groups, a total of 4 groups. After the nude mouse is anesthetized and centered on the spine, wipe back and forth with two sterile cotton swabs dipped in saline on the left and right thighs. Each cotton swab is wiped back and forth 5 times, and then a dry sterile cotton swab is wiped back and forth 3 times. Waiting dry. Next, draw a 1.5 cm * 1.5 cm square box on both thighs, measure the transepidermal water loss (TEWL), and record it as the basic value. Then, in the four corners of the thighs on both sides, peel off 10-15 times with about 3 cm * 2.5 cm tape, staying for 10 seconds each time. Then measure the loss of transdermal water dispersion. Finally, administer the medicine according to each group. Apply the hydrogel prepared according to the formula in Table 3 back and forth on a fixed area of 4.5 cm * 2.5 cm for 3 minutes until it is dry and can no longer be applied. The process of cleaning, drying, measuring and dosing is repeated every day. Therefore, the transdermal water loss on day 0 (basic value before tearing), day 0 (after tearing), day 1, day 2 and day 3 were recorded.

The formulas of the control group and the experimental groups A-C are shown in Table 3 below, and the content of calcium ion, magnesium ion, sodium ion, potassium ion and chloride ion in the ion regulator is shown in Table 1.

The experimental results See Figure 1, day 2, the average amount of transdermal water loss after deducting the value of each basic control groups were 23.70g / h / m ^2, the experimental group A 21.09g / h / m ² , Experimental group B 18.80g/h/m ² and experimental group C 14.26g/h/m ² . It can be seen that compared with the use of ion modifiers (experimental group A) and Ganoderma lucidum extract alone (experimental group B), experimental group C, which uses both ion modifiers and Ganoderma lucidum extract, has a loss of transdermal water dispersion. The reduction in volume is even more significant. In other words, the repair effect of the skin barrier is better. It is worth noting that, compared with the control group, the reduction in transdermal water loss (9.44) of the skin using the composition of the present invention is greater than the sum of the reduction in transdermal water loss of using Ganoderma lucidum extract and ion modifier alone (2.61+4.90), it can be seen that the Ganoderma lucidum extract and the ion regulator have a synergistic effect.

In addition, calculate the recovery rate of each group on the second day. The recovery rate calculation method is {1-[(TEWL average on day 2-average base value)/(after tearing on day 0 TEWL average-basic value average)]}* 100. As shown in Figure 2, the recovery rate of the control group was 54.3%, the recovery rate of the experimental group A was 50%, the recovery rate of the experimental group B was 55.1%, and the recovery rate of the experimental group C was 66.7%. In other words, the recovery rate of experimental group C increased by 12.4% compared to the control group. This may be due to the fact that the use of Ganoderma lucidum extract alone can promote the proliferation of keratinocytes, but the specific ion combination and ratio in the ion modifier can adjust the calcium ion concentration gradient in the epidermis in an inverted trapezoidal distribution, accelerating the proliferation of skin keratinocytes to achieve The effect of repairing the skin barrier. Secondly, calcium ions can also help keratinocytes differentiate.

In the composition of the present invention, the Ganoderma lucidum extract in the composition promotes cell regeneration and accelerates the proliferation of skin keratinocytes. Then use the ion combination of a specific ratio in the ion regulator to restore the inverted trapezoidal distribution of the calcium ion concentration gradient in the skin epidermis to provide an environment suitable for the growth of keratinocytes. Finally, a specific ratio of ion combinations can sustainably maintain the inverted trapezoidal distribution of calcium ion concentration gradient in the skin barrier layer to maintain the function of the new skin barrier. Repairing the skin barrier by the composition of the present invention can prevent external stimuli from invading the skin and loss of skin moisture, and avoid the uncomfortable feeling of swelling and hot spurs caused by inflammation after the skin is exposed to external stimuli. Secondly, the composition of the present invention can also be used on the skin under pathological conditions to treat or improve skin discomfort or abnormal symptoms by repairing the skin barrier, including skin itching symptoms of dialysis patients.

Although the present invention has been disclosed in the above embodiments, it is not intended to limit the present invention. Anyone familiar with the art can make various changes and modifications without departing from the spirit and scope of the present invention. Therefore, the protection of the present invention The scope shall be subject to those defined in the attached patent scope.

Claims (16)

A composition for repairing the skin barrier, comprising: A Ganoderma lucidum extract; and An ion regulator, including calcium ion, magnesium ion, sodium ion, potassium ion and chloride ion, Wherein the total weight of the composition is based on 100%, the weight percentage of the Ganoderma lucidum extract is 0.0000072% to 0.11%, the weight percentage of the calcium ion is 0.0001244% to 0.04998%, and the weight percentage of the magnesium ion is 0.0000412% to 0.03157 %, the weight percentage of the sodium ion is 0.0002133% to 0.09114%, the weight percentage of the potassium ion is 0.0000875% to 0.03301%, and the weight percentage of the chloride ion is 0.0004754% to 0.16639%. The composition according to claim 1, wherein the Ganoderma lucidum extract comprises a copolymer of dextran and amino glucose, the glucan comprises α-glucan, β-glucan or a combination thereof, and the amino group Glucose includes N-acetylglucosamine, N-acetylmuramic acid, or a combination thereof. The composition according to claim 1, wherein the Ganoderma lucidum extract comprises micron-grade Ganoderma lucidum extract or nano-grade Ganoderma lucidum extract, wherein the weight percentage of the micro-grade Ganoderma lucidum extract is 0.00000072% to 0.088%, nano The weight percentage of the grade Ganoderma extract is 0.00018% to 0.11%. The composition according to claim 1, further comprising a lipid with a weight percentage of 0.001% to 15%. The composition according to claim 4, wherein the lipid comprises ceramide, glyceride, cholesterol, free fatty acid, or a combination thereof. The composition according to claim 5, wherein the ceramide comprises ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6, and ceramide 7 , Ceramide 8, Ceramide 9, or a combination thereof. The composition according to claim 1, wherein the composition is used to treat skin diseases or improve skin discomfort or abnormal symptoms caused by diseases, and the skin diseases include atopic dermatitis, seborrheic dermatitis, contact Dermatitis, lupus erythematosus, lichen planus, urticaria, keratosis, acne, psoriasis, or ichthyosis. The composition according to claim 1, wherein the composition is in the form of a liquid, an essence, a lotion, a makeup remover, a facial mask, a wipe product, a lotion, a cream, an ointment, or a gel. The composition according to any one of claims 1 to 7, further comprising a cosmetically acceptable carrier. The composition according to claim 9, wherein the cosmetically acceptable carrier comprises a solvent, an emollient, a moisturizer, an emulsifier, a thickener, an antioxidant, a preservative, or a combination thereof. The composition according to claim 10, wherein The weight percentage of the emollient is 2% to 30%; The weight percentage of the humectant is 0.1% to 20%; The weight percentage of the emulsifier is 0.1% to 10%; The weight percentage of the thickener is 0.1% to 5%; The weight percentage of the antioxidant is 0.01% to 5%; and The weight percentage of the preservative is 0.0004% to 5%. The composition according to any one of claims 1 to 7, further comprising a pharmaceutically acceptable carrier. A use of the composition according to any one of claims 1 to 6 is for preparing a preparation for treating skin diseases or improving skin discomfort or abnormal symptoms caused by diseases. The use according to claim 13, wherein the skin diseases include atopic dermatitis, seborrheic dermatitis, contact dermatitis, lupus erythematosus, lichen planus, urticaria, keratosis, acne, psoriasis, Or ichthyosis. A use of the composition according to any one of claims 1 to 6, for preparing a preparation for treating skin diseases or improving skin discomfort or abnormal symptoms caused by diseases, wherein the composition is administered daily At least once. The use according to claim 15, wherein the recovery rate of the skin disease or the skin discomfort or abnormal symptoms caused by the disease is increased by 10% or more compared with the control group when the composition is administered for two days.

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