TW202021637A - 吸入性一氧化氮（ｉＮＯ）用於改善嚴重低血氧症之用途 - Google Patents
吸入性一氧化氮（ｉＮＯ）用於改善嚴重低血氧症之用途 Download PDFInfo
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- TW202021637A TW202021637A TW108128093A TW108128093A TW202021637A TW 202021637 A TW202021637 A TW 202021637A TW 108128093 A TW108128093 A TW 108128093A TW 108128093 A TW108128093 A TW 108128093A TW 202021637 A TW202021637 A TW 202021637A
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- oxygen saturation
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- 230000006872 improvement Effects 0.000 title claims description 12
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 title abstract description 164
- 206010021143 Hypoxia Diseases 0.000 title abstract description 12
- 208000018875 hypoxemia Diseases 0.000 title abstract description 11
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 56
- 239000001301 oxygen Substances 0.000 claims abstract description 56
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 56
- 238000000034 method Methods 0.000 claims abstract description 53
- 230000029058 respiratory gaseous exchange Effects 0.000 claims description 47
- 239000008280 blood Substances 0.000 claims description 39
- 210000004369 blood Anatomy 0.000 claims description 39
- 230000003434 inspiratory effect Effects 0.000 claims description 36
- 238000002640 oxygen therapy Methods 0.000 claims description 23
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- 230000035945 sensitivity Effects 0.000 description 29
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- 238000011947 six minute walk test Methods 0.000 description 14
- 238000012360 testing method Methods 0.000 description 11
- 201000010099 disease Diseases 0.000 description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 10
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 7
- 208000002815 pulmonary hypertension Diseases 0.000 description 7
- 230000000875 corresponding effect Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 230000001225 therapeutic effect Effects 0.000 description 6
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
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- 201000003883 Cystic fibrosis Diseases 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
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- MGWGWNFMUOTEHG-UHFFFAOYSA-N 4-(3,5-dimethylphenyl)-1,3-thiazol-2-amine Chemical compound CC1=CC(C)=CC(C=2N=C(N)SC=2)=C1 MGWGWNFMUOTEHG-UHFFFAOYSA-N 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- 206010014561 Emphysema Diseases 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
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- 206010035664 Pneumonia Diseases 0.000 description 1
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- 230000007423 decrease Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
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- 238000002716 delivery method Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 229940126534 drug product Drugs 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
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- 230000000670 limiting effect Effects 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N nitrogen dioxide Inorganic materials O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
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- 229940124549 vasodilator Drugs 0.000 description 1
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Images
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- A61M16/021—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes operated by electrical means
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- A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
- A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
- A61M2016/0021—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with a proportional output signal, e.g. from a thermistor
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- A61M2202/00—Special media to be introduced, removed or treated
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862717433P | 2018-08-10 | 2018-08-10 | |
| US62/717,433 | 2018-08-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW202021637A true TW202021637A (zh) | 2020-06-16 |
Family
ID=69415166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW108128093A TW202021637A (zh) | 2018-08-10 | 2019-08-07 | 吸入性一氧化氮（ｉＮＯ）用於改善嚴重低血氧症之用途 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20230158260A1 (https=) |
| EP (1) | EP3833418A4 (https=) |
| JP (1) | JP2021533866A (https=) |
| CN (1) | CN112969491A (https=) |
| AR (1) | AR117632A1 (https=) |
| AU (2) | AU2019319953B2 (https=) |
| CA (1) | CA3108273A1 (https=) |
| IL (1) | IL280444A (https=) |
| MX (3) | MX2021001430A (https=) |
| TW (1) | TW202021637A (https=) |
| WO (1) | WO2020033768A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112019016708B1 (pt) | 2017-02-27 | 2024-01-30 | Third Pole, Inc | Sistemas de geração de óxido nítrico |
| WO2018157175A1 (en) | 2017-02-27 | 2018-08-30 | Third Pole, Inc. | Systems and methods for ambulatory generation of nitric oxide |
| MX2020010523A (es) | 2017-02-27 | 2021-02-09 | Third Pole Inc | Sistemas y metodos para generar oxido nitrico. |
| CN114269685A (zh) | 2019-05-15 | 2022-04-01 | 第三极股份有限公司 | 用于一氧化氮生成的电极 |
| EP3969416A4 (en) | 2019-05-15 | 2023-11-01 | Third Pole, Inc. | SYSTEMS AND DEVICES FOR GENERATING NITROGEN OXIDE |
| WO2020232414A1 (en) | 2019-05-15 | 2020-11-19 | Third Pole, Inc. | Architectures for production of nitric oxide |
| EP4069069A4 (en) | 2020-01-11 | 2024-07-03 | Third Pole, Inc. | SYSTEMS AND METHODS FOR NITROGEN OXIDE PRODUCTION WITH HUMIDITY CONTROL |
| JP2023527463A (ja) * | 2020-05-29 | 2023-06-28 | ベレロフォン・セラピューティクス | 気体状薬剤のパルス式送達方法 |
| EP4167920A4 (en) | 2020-06-18 | 2024-06-12 | Third Pole, Inc. | Systems and methods for preventing and treating infections with nitric oxide |
| WO2022082072A1 (en) | 2020-10-16 | 2022-04-21 | Third Pole, Inc. | Nitric oxide generation process controls |
| EP4405019A4 (en) | 2021-09-23 | 2025-07-16 | Third Pole Inc | SYSTEMS AND METHODS FOR PROVIDING NITRIC OXIDE |
| WO2023201363A2 (en) | 2022-04-14 | 2023-10-19 | Third Pole, Inc. | Delivery of medicinal gas in a liquid medium |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5890490A (en) * | 1996-11-29 | 1999-04-06 | Aylsworth; Alonzo C. | Therapeutic gas flow monitoring system |
| US20060201504A1 (en) * | 2005-03-08 | 2006-09-14 | Singhal Aneesh B | High-flow oxygen delivery system and methods of use thereof |
| US8020558B2 (en) * | 2007-01-26 | 2011-09-20 | Cs Medical, Inc. | System for providing flow-targeted ventilation synchronized to a patient's breathing cycle |
| CA2781295C (en) * | 2009-11-20 | 2018-02-13 | Geno Llc | Nitric oxide delivery system |
| US20120093948A1 (en) * | 2009-11-20 | 2012-04-19 | Fine David H | Nitric Oxide Treatments |
| WO2014160373A1 (en) * | 2013-03-13 | 2014-10-02 | Ino Therapeutics Llc | Devices and methods for monitoring oxygenation during treatment with delivery of nitric oxide |
| JP2019506259A (ja) * | 2015-12-11 | 2019-03-07 | ベロ バイオテック エルエルシー | 線維症に対処するために一酸化窒素を含むガスを投与するための方法及び装置 |
| US10398820B2 (en) * | 2016-02-12 | 2019-09-03 | Mallinckrodt Hospital Products IP Limited | Use and monitoring of inhaled nitric oxide with left ventricular assist devices |
| CA3087195A1 (en) * | 2017-12-28 | 2019-07-04 | Bellerophon Pulse Technologies Llc | Use of inhaled nitric oxide and oxygen for the treatment of pulmonary hypertension |
-
2019
- 2019-08-07 TW TW108128093A patent/TW202021637A/zh unknown
- 2019-08-08 EP EP19846257.4A patent/EP3833418A4/en active Pending
- 2019-08-08 AU AU2019319953A patent/AU2019319953B2/en active Active
- 2019-08-08 JP JP2021506750A patent/JP2021533866A/ja active Pending
- 2019-08-08 CA CA3108273A patent/CA3108273A1/en active Pending
- 2019-08-08 MX MX2021001430A patent/MX2021001430A/es unknown
- 2019-08-08 CN CN201980066311.9A patent/CN112969491A/zh active Pending
- 2019-08-08 US US17/265,103 patent/US20230158260A1/en not_active Abandoned
- 2019-08-08 WO PCT/US2019/045806 patent/WO2020033768A1/en not_active Ceased
- 2019-08-09 AR ARP190102281A patent/AR117632A1/es not_active Application Discontinuation
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2021
- 2021-01-27 IL IL280444A patent/IL280444A/en unknown
- 2021-02-04 MX MX2025006329A patent/MX2025006329A/es unknown
- 2021-02-04 MX MX2025003262A patent/MX2025003262A/es unknown
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2025
- 2025-05-14 AU AU2025203477A patent/AU2025203477A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3108273A1 (en) | 2020-02-13 |
| US20230158260A1 (en) | 2023-05-25 |
| IL280444A (en) | 2021-03-25 |
| MX2025003262A (es) | 2025-05-02 |
| MX2021001430A (es) | 2021-05-12 |
| AU2019319953A1 (en) | 2021-03-11 |
| CN112969491A (zh) | 2021-06-15 |
| EP3833418A4 (en) | 2022-08-10 |
| AU2019319953B2 (en) | 2025-02-27 |
| MX2025006329A (es) | 2025-07-01 |
| JP2021533866A (ja) | 2021-12-09 |
| EP3833418A1 (en) | 2021-06-16 |
| AU2025203477A1 (en) | 2025-05-29 |
| WO2020033768A1 (en) | 2020-02-13 |
| AR117632A1 (es) | 2021-08-18 |
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