AU2019319953B2 - Use of inhaled nitric oxide (INO) for the improvement of severe hypoxemia - Google Patents

Use of inhaled nitric oxide (INO) for the improvement of severe hypoxemia Download PDF

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Publication number
AU2019319953B2
AU2019319953B2 AU2019319953A AU2019319953A AU2019319953B2 AU 2019319953 B2 AU2019319953 B2 AU 2019319953B2 AU 2019319953 A AU2019319953 A AU 2019319953A AU 2019319953 A AU2019319953 A AU 2019319953A AU 2019319953 B2 AU2019319953 B2 AU 2019319953B2
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Australia
Prior art keywords
patient
nitric oxide
breath
inhaled nitric
delivered
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Application number
AU2019319953A
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AU2019319953A1 (en
Inventor
Deborah Quinn
Parag Shah
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Mallinckrodt Pharmaceuticals Ireland Ltd
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Mallinckrodt Pharmaceuticals Ireland Ltd
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Publication of AU2019319953A1 publication Critical patent/AU2019319953A1/en
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Assigned to BELLEROPHON THERAPEUTICS, INC. reassignment BELLEROPHON THERAPEUTICS, INC. Amend patent request/document other than specification (104) Assignors: BELLEROPHON THERAPEUTICS
Priority to AU2025203477A priority Critical patent/AU2025203477A1/en
Assigned to MALLINCKRODT PHARMACEUTICALS IRELAND LIMITED reassignment MALLINCKRODT PHARMACEUTICALS IRELAND LIMITED Request for Assignment Assignors: BELLEROPHON THERAPEUTICS, INC.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/021—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes operated by electrical means
    • A61M16/022—Control means therefor
    • A61M16/024—Control means therefor including calculation means, e.g. using a processor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/0816—Measuring devices for examining respiratory frequency
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/08—Inhaling devices inserted into the nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/06—Respiratory or anaesthetic masks
    • A61M16/0666—Nasal cannulas or tubing
    • A61M16/0672—Nasal cannula assemblies for oxygen therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/1005—Preparation of respiratory gases or vapours with O2 features or with parameter measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/12—Preparation of respiratory gases or vapours by mixing different gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
    • A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
    • A61M2016/0021—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with a proportional output signal, e.g. from a thermistor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/02—Gases
    • A61M2202/0208—Oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/02—Gases
    • A61M2202/0266—Nitrogen (N)
    • A61M2202/0275—Nitric oxide [NO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/20—Blood composition characteristics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/20—Blood composition characteristics
    • A61M2230/205—Blood composition characteristics partial oxygen pressure (P-O2)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Emergency Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Otolaryngology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Physics & Mathematics (AREA)
  • Communicable Diseases (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Oncology (AREA)
  • Inorganic Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2019319953A 2018-08-10 2019-08-08 Use of inhaled nitric oxide (INO) for the improvement of severe hypoxemia Active AU2019319953B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2025203477A AU2025203477A1 (en) 2018-08-10 2025-05-14 Use of inhaled nitric oxide (iNO) for the improvement of severe hypoxemia

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862717433P 2018-08-10 2018-08-10
US62/717,433 2018-08-10
PCT/US2019/045806 WO2020033768A1 (en) 2018-08-10 2019-08-08 Use of inhaled nitric oxide (ino) for the improvement of severe hypoxemia

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2025203477A Division AU2025203477A1 (en) 2018-08-10 2025-05-14 Use of inhaled nitric oxide (iNO) for the improvement of severe hypoxemia

Publications (2)

Publication Number Publication Date
AU2019319953A1 AU2019319953A1 (en) 2021-03-11
AU2019319953B2 true AU2019319953B2 (en) 2025-02-27

Family

ID=69415166

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2019319953A Active AU2019319953B2 (en) 2018-08-10 2019-08-08 Use of inhaled nitric oxide (INO) for the improvement of severe hypoxemia
AU2025203477A Pending AU2025203477A1 (en) 2018-08-10 2025-05-14 Use of inhaled nitric oxide (iNO) for the improvement of severe hypoxemia

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2025203477A Pending AU2025203477A1 (en) 2018-08-10 2025-05-14 Use of inhaled nitric oxide (iNO) for the improvement of severe hypoxemia

Country Status (11)

Country Link
US (1) US20230158260A1 (https=)
EP (1) EP3833418A4 (https=)
JP (1) JP2021533866A (https=)
CN (1) CN112969491A (https=)
AR (1) AR117632A1 (https=)
AU (2) AU2019319953B2 (https=)
CA (1) CA3108273A1 (https=)
IL (1) IL280444A (https=)
MX (3) MX2021001430A (https=)
TW (1) TW202021637A (https=)
WO (1) WO2020033768A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112019016708B1 (pt) 2017-02-27 2024-01-30 Third Pole, Inc Sistemas de geração de óxido nítrico
WO2018157175A1 (en) 2017-02-27 2018-08-30 Third Pole, Inc. Systems and methods for ambulatory generation of nitric oxide
MX2020010523A (es) 2017-02-27 2021-02-09 Third Pole Inc Sistemas y metodos para generar oxido nitrico.
CN114269685A (zh) 2019-05-15 2022-04-01 第三极股份有限公司 用于一氧化氮生成的电极
EP3969416A4 (en) 2019-05-15 2023-11-01 Third Pole, Inc. SYSTEMS AND DEVICES FOR GENERATING NITROGEN OXIDE
WO2020232414A1 (en) 2019-05-15 2020-11-19 Third Pole, Inc. Architectures for production of nitric oxide
EP4069069A4 (en) 2020-01-11 2024-07-03 Third Pole, Inc. SYSTEMS AND METHODS FOR NITROGEN OXIDE PRODUCTION WITH HUMIDITY CONTROL
JP2023527463A (ja) * 2020-05-29 2023-06-28 ベレロフォン・セラピューティクス 気体状薬剤のパルス式送達方法
EP4167920A4 (en) 2020-06-18 2024-06-12 Third Pole, Inc. Systems and methods for preventing and treating infections with nitric oxide
WO2022082072A1 (en) 2020-10-16 2022-04-21 Third Pole, Inc. Nitric oxide generation process controls
EP4405019A4 (en) 2021-09-23 2025-07-16 Third Pole Inc SYSTEMS AND METHODS FOR PROVIDING NITRIC OXIDE
WO2023201363A2 (en) 2022-04-14 2023-10-19 Third Pole, Inc. Delivery of medicinal gas in a liquid medium

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120093948A1 (en) * 2009-11-20 2012-04-19 Fine David H Nitric Oxide Treatments

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5890490A (en) * 1996-11-29 1999-04-06 Aylsworth; Alonzo C. Therapeutic gas flow monitoring system
US20060201504A1 (en) * 2005-03-08 2006-09-14 Singhal Aneesh B High-flow oxygen delivery system and methods of use thereof
US8020558B2 (en) * 2007-01-26 2011-09-20 Cs Medical, Inc. System for providing flow-targeted ventilation synchronized to a patient's breathing cycle
CA2781295C (en) * 2009-11-20 2018-02-13 Geno Llc Nitric oxide delivery system
WO2014160373A1 (en) * 2013-03-13 2014-10-02 Ino Therapeutics Llc Devices and methods for monitoring oxygenation during treatment with delivery of nitric oxide
JP2019506259A (ja) * 2015-12-11 2019-03-07 ベロ バイオテック エルエルシー 線維症に対処するために一酸化窒素を含むガスを投与するための方法及び装置
US10398820B2 (en) * 2016-02-12 2019-09-03 Mallinckrodt Hospital Products IP Limited Use and monitoring of inhaled nitric oxide with left ventricular assist devices
CA3087195A1 (en) * 2017-12-28 2019-07-04 Bellerophon Pulse Technologies Llc Use of inhaled nitric oxide and oxygen for the treatment of pulmonary hypertension

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120093948A1 (en) * 2009-11-20 2012-04-19 Fine David H Nitric Oxide Treatments

Also Published As

Publication number Publication date
CA3108273A1 (en) 2020-02-13
US20230158260A1 (en) 2023-05-25
IL280444A (en) 2021-03-25
MX2025003262A (es) 2025-05-02
MX2021001430A (es) 2021-05-12
AU2019319953A1 (en) 2021-03-11
CN112969491A (zh) 2021-06-15
EP3833418A4 (en) 2022-08-10
MX2025006329A (es) 2025-07-01
JP2021533866A (ja) 2021-12-09
EP3833418A1 (en) 2021-06-16
AU2025203477A1 (en) 2025-05-29
WO2020033768A1 (en) 2020-02-13
AR117632A1 (es) 2021-08-18
TW202021637A (zh) 2020-06-16

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Owner name: BELLEROPHON THERAPEUTICS, INC.

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Owner name: MALLINCKRODT PHARMACEUTICALS IRELAND LIMITED

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