TW202020146A - 含nef之t細胞及其產生方法 - Google Patents

含nef之t細胞及其產生方法 Download PDF

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TW202020146A
TW202020146A TW108126647A TW108126647A TW202020146A TW 202020146 A TW202020146 A TW 202020146A TW 108126647 A TW108126647 A TW 108126647A TW 108126647 A TW108126647 A TW 108126647A TW 202020146 A TW202020146 A TW 202020146A
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nef
tcr
mutant
domain
cell
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TW108126647A
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English (en)
Chinese (zh)
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曉虎 范
趙云程
俞大偉
支武吉南
王趁趁
莊秋傳
王平豔
郭璇璇
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大陸商南京傳奇生物科技有限公司
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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TW108126647A 2018-07-26 2019-07-26 含nef之t細胞及其產生方法 TW202020146A (zh)

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WOPCT/CN2018/097235 2018-07-26
CN2018097235 2018-07-26

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US (1) US20220177524A1 (enExample)
EP (1) EP3827075A4 (enExample)
JP (1) JP2021532742A (enExample)
KR (1) KR20210049806A (enExample)
CN (2) CN112771154B (enExample)
AU (1) AU2019312411A1 (enExample)
CA (1) CA3103337A1 (enExample)
IL (1) IL280240A (enExample)
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US9273283B2 (en) * 2009-10-29 2016-03-01 The Trustees Of Dartmouth College Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
CN115768899B (zh) * 2020-03-09 2026-03-27 詹森生物科技公司 用于定量重组载体核酸整合的组合物和方法
WO2022116086A1 (en) * 2020-12-03 2022-06-09 Janssen Biotech, Inc. Bcma-targeted car-t cell therapy for multiple myeloma
EP4259784A4 (en) * 2020-12-14 2025-01-15 Nanjing Legend Biotech Co., Ltd. METHODS AND COMPOSITIONS FOR DEPOVERY OF NATURAL KILLER CELLS AND USES THEREOF IN CELLULAR THERAPIES
CA3207206A1 (en) * 2021-02-01 2022-08-04 Lingfeng LIU Targeted protein degradation system and use thereof
CN117396498A (zh) * 2021-03-18 2024-01-12 威斯塔解剖学和生物学研究所 靶向IL13Rα2的DNA编码的双特异性抗体以及在癌症治疗中的使用方法
JP2024528077A (ja) * 2021-07-30 2024-07-26 ▲い▼尊生物医薬（浙江）有限公司 汎用型ｔ細胞およびその応用
JP2024540275A (ja) * 2021-11-04 2024-10-31 ヤンセン バイオテック， インク． Ｂｃｍａを標的とする、多発性骨髄腫のためのｃａｒ－ｔ細胞療法関連出願の相互参照
WO2023077343A1 (en) * 2021-11-04 2023-05-11 Janssen Biotech, Inc. Bcma-targeted car-t cell therapy for multiple myeloma
JP2025524921A (ja) * 2022-07-29 2025-08-01 レジェンド バイオテック アイルランド リミテッド 細胞療法の持続性を促進するための方法
WO2024098037A1 (en) * 2022-11-04 2024-05-10 WUGEN, Inc. Generation of cd3 expressing immune cells for use in conjunction with cd3 binding bispecific targeting agents
WO2024153211A1 (en) * 2023-01-19 2024-07-25 Nanjing Legend Biotech Co., Ltd. Fusion polypeptides for targeted protein degradation and mehtods of use thereof

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EP1409694A4 (en) * 2001-07-05 2006-02-08 Chiron Corp POLYNUCLEOTIDES ENCODING ANTIGENIC POLYPEPTIDES OF HIV SUBTYPE B AND / OR SUBTYPE C, POLYPEPTIDES AND USES THEREOF
EP2420248A1 (en) * 2004-08-17 2012-02-22 Institut Gustave Roussy Mutated HIV NEF for modulating immunity
US9273283B2 (en) * 2009-10-29 2016-03-01 The Trustees Of Dartmouth College Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
SG10201806573TA (en) * 2012-05-25 2018-09-27 Cellectis Methods for engineering allogeneic and immunosuppressive resistant t cell for immunotherapy
ES2959480T3 (es) * 2014-02-07 2024-02-26 Univ Mcmaster Acoplador de células T - antígeno trifuncional y métodos y usos del mismo
WO2015164759A2 (en) * 2014-04-25 2015-10-29 Bluebird Bio, Inc. Mnd promoter chimeric antigen receptors
BR112018014585A2 (pt) * 2016-01-21 2018-12-11 Pfizer receptores de antígeno quiméricos que direcionam o receptor do fator de crescimento epidérmico variante iii
AU2017248259A1 (en) * 2016-04-07 2018-10-25 Bluebird Bio, Inc. Chimeric antigen receptor T cell compositions
AU2017326748A1 (en) * 2016-09-14 2019-04-11 Benitec Biopharma Limited Reagents for producing T-cells with non-functional T-cell receptors (TCRs) compositions comprising same and use thereof
EP4759318A2 (en) * 2017-04-14 2026-06-17 The General Hospital Corporation Chimeric antigen receptor t cells targeting the tumor microenvironment
CN110520196A (zh) * 2017-04-19 2019-11-29 艾洛基治疗公司 改进的t细胞组合物和方法

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CN112771154B (zh) 2025-01-03
KR20210049806A (ko) 2021-05-06
WO2020020359A1 (en) 2020-01-30
CN119661659A (zh) 2025-03-21
EP3827075A1 (en) 2021-06-02
MX2021000934A (es) 2021-05-27
CN112771154A (zh) 2021-05-07
IL280240A (en) 2021-03-25
JP2021532742A (ja) 2021-12-02
US20220177524A1 (en) 2022-06-09
EP3827075A4 (en) 2022-08-03
CA3103337A1 (en) 2020-01-30
AU2019312411A1 (en) 2021-01-07

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