TW202019508A - Liquid drug delivery apparatus and drug delivery method - Google Patents

Abstract

A liquid drug delivery apparatus and a drug delivery method. The apparatus is provided with an upper housing and a lower housing which are capable of relative rotation, the upper housing being internally embedded with an upper rotary component, the lower housing being internally embedded with a lower rotary component and provided with a spring. Inner walls of the upper rotary component and the lower rotary component are respectively provided with mutually matching slide surfaces, so that the lower rotary component moves away from the upper housing and compresses the spring when rotating relative to the upper rotary component along a first direction. A stopping and limiting structure is also provided, to limit the rotation range when the lower rotary component rotates relative to the upper rotary component along the first direction, in order to prevent the slide surfaces from disengaging. A guide tube moves up and down with the lower rotary component. When the lower rotary component rotates along the first direction, the guide tube moves down. When the lower rotary component rotates relative to the upper rotary component along a second direction, opposite to the first direction, the spring resets and the guide tube moves up. The liquid drug delivery apparatus is gentle during use and simple to operate, and has good user acceptance.

Description

Liquid drug delivery device and drug delivery method

The invention relates to a medical device, in particular to a liquid drug delivery device for quantitative drug delivery, and a drug delivery method adopted by the device.

Nebulization inhalation therapy uses an atomization device to disperse the medicine into tiny droplets or particles, suspend it in the gas, and enter the respiratory tract and lungs to achieve the purpose of clean airway, humidified airway, local treatment and systemic treatment. Common atomizing devices include manual jet atomizers, metered dose inhalers, dry powder inhalers, etc. Among them, the metered dose inhaler is popular because it has the advantages of metering, simple operation, easy to carry, ready to use, no need for regular disinfection, and no cross-infection in the hospital. The metered dose inhaler is usually composed of a sealed medicine storage tank, a suction pipe, a metered valve, and a spray pipe. One method is to use a spring as an energy source to achieve drug delivery and atomization spray.

For example, US Patent Publication No. US2009/0114215A1 discloses an atomizer having a built-in replaceable liquid medicine container, a suction pipe movable relative to the liquid medicine container, a check valve, a pressure chamber, a nozzle; mist The carburetor has an upper housing and a lower housing that can rotate relatively. The upper housing is embedded with an upper rotating component, the lower housing has a lower rotating component with a spring, and the inner walls of the upper rotating component and the lower rotating component are provided with The sliding surfaces cooperate with each other, so that when rotating in one direction, the lower rotating component moves away from the upper rotating component and compresses the spring; a locking member is provided, and when the sliding surface of the lower rotating component is separated from the upper rotating component, the locking component faces the lower rotating component Limit. When in use, the upper and lower parts are relatively rotated, so that the lower rotating component compresses the spring, and at the same time the suction pipe moves downward, the liquid enters the pressure chamber through the one-way valve, and when the sliding surface of the upper and lower rotating components disengage, the locking member Limit the lower rotating part; when spraying, release the lower rotating part by pressing the button. Under the elastic force of the spring, the lower rotating part quickly resets, the suction pipe moves up synchronously, and the kinetic energy released by the spring instantaneously causes the medical liquid to quickly output to form a jet Or aerosol.

The above structure is a typical structure of a liquid drug delivery device with a spring as an energy source. When used in soft nebulizers, needleless syringes, nasal sprays, etc., such structures generally use a press-release button as Trigger device, because those skilled in the art generally believe that such a device requires relatively large energy to disperse the liquid medicine into droplets or aerosol in a very short time to enter the body and be absorbed by the body. The release type makes the spring in a free state instantly. However, when the trigger device is activated, it is often accompanied by obvious vibration or sound, which produces bad psychological cues or physiological stress to the user, resulting in a decrease in the user's acceptance of the medication device, especially the nebulized inhalation that needs to be used in conjunction with breathing In the device, it is required to enter the inhalation state while releasing the medicine, and the physiological stress response will make it difficult for the user to control the breathing loop, resulting in an undesirable stress response. Since this type of drug delivery device is generally used for chronic obstructive pneumonia or diabetes insulin treatment, it has the characteristics of long-term high-frequency medication, and the user's adaptability to the drug delivery device directly affects whether the treatment can be smoothly implemented, and poor stress It has created certain obstacles for users to receive such drug delivery devices many times over a long period of time and to use drugs correctly.

Therefore, it is necessary to improve the triggering method of this type of liquid drug delivery device to avoid adverse physiological stress on the user and increase the user's acceptance.

The object of the present invention is to provide a liquid drug delivery device that solves the problems of vibration and sound when triggered in existing devices through structural improvements; another invention object of the present invention is to provide a liquid drug delivery method that cooperates with such a delivery device.

In order to achieve the above-mentioned object of the invention, the technical solution adopted by the present invention is: a liquid medicine delivery device, which has a liquid medicine container and a medicine atomizing spray structure, the medicine atomizing spray structure contains a conduit matched with the liquid medicine container, It has an upper shell and a lower shell which can rotate relatively, the upper shell is embedded with an upper rotating component, the lower shell is embedded with a lower rotating component and is provided with a spring, the inner walls of the upper rotating component and the lower rotating component are respectively There is a sliding surface that cooperates with each other, so that the lower rotating member moves away from the upper housing and compresses the spring when rotating relative to the upper rotating member in the first direction; a stop limit element structure is provided, the stop limit The element structure limits the rotation amplitude when the lower rotating member rotates relative to the upper rotating member in the first direction to prevent the sliding surfaces of the upper rotating member and the lower rotating member from coming off, and the catheter follows the lower rotating member in the up and down direction In motion, when the lower rotating member rotates in the first direction, the catheter moves downward; when the lower rotating member rotates relative to the upper rotating member in the second direction opposite to the first direction, the spring returns and the catheter moves upward.

In the above technical solution, by setting the stopper limit structure, the sliding surfaces of the upper rotating member and the lower rotating member cannot be detached, so there is no situation where the spring enters a free state instantaneously, and does not appear in use Strong vibration or noise. When in use, the relative rotation of the upper rotating member and the lower rotating member realizes the delivery of the drug solution. By controlling the rotation angle, the degree of compression of the spring and the vertical movement distance of the catheter can be controlled, so as to correspondingly control the liquid pumping volume or output volume, and realize the adjustment of the drug output dose.

In the above technical solution, the relative rotation angle of the upper rotating mechanism and the lower rotating mechanism is determined by the setting of the sliding surface. When only a pair of sliding surfaces is provided, the maximum relative rotating angle can be set to not exceed 360°; accordingly, set For two pairs of sliding surfaces, the relative rotation angle is preferably 160°-180°; if four pairs of sliding surfaces are provided, the rotation angle is generally less than 90°.

In the above technical solution, the structure of the stopper is that a stopper platform is provided at the proximal end of the sliding surface of the upper rotating component and the sliding surface of the lower rotating component, respectively. A limit boss is formed at the end, wherein the stop platform on any one of the rotating parts cooperates with the limit boss on the other rotating part, so that the two limit bosses will conflict with each other after passing through the stop platform .

Alternatively, a lower housing stopper is provided on the outer wall of the lower housing, an upper housing stopper is correspondingly provided on the inner wall of the upper housing, and a part of the upper housing is sleeved on the lower housing, The lower housing stopper cooperates with the upper housing stopper to form the stop limit structure.

A further technical solution is provided with a reverse driving mechanism. After the upper rotating member and the lower rotating member are relatively rotated to the stop position in the first direction, the reverse driving mechanism drives the two to relatively rotate in the opposite direction.

The reverse drive mechanism is a coil spring drive mechanism. Or, the reverse drive mechanism uses a motor as a power mechanism and a gear or screw as a transmission mechanism. The motor here can be a permanent magnet linear stepper motor or a planetary gear motor. When the motor is used for driving, the rotation angle can be preset and controlled by the controller. At this time, the stop limit element structure plays a role in safety protection. The start of the reverse drive mechanism can also use the sensor to detect the strength of the respiratory airflow, for example, when the respiratory airflow reaches a set threshold, the drive motor is started.

In order to achieve another object of the present invention, a liquid medicine delivery method is provided, which is realized by using the above-mentioned liquid medicine delivery device, firstly rotating the lower rotating member relative to the upper rotating member in a first direction to a stop position, in the process The spring is in a compressed state, and the catheter moves downward to draw liquid; the lower rotating member is then rotated relative to the upper rotating member in a second direction opposite to the first direction, and the catheter is moved upward to release the medicine from the container while releasing the spring The medium output forms a jet or aerosol; the stroke of the catheter is 5-20 mm, and the time to rotate in the second direction is less than 5 seconds.

In the prior art, it is generally believed that in order to disperse the liquid medicine into droplets or aerosols in a very short time, it is necessary to use a press release to make the spring in a free state instantaneously. The present invention has unexpectedly discovered that using reverse rotation instead of instantaneous release can also achieve the desired effect.

In the above technical solution, the stroke of the catheter is related to the dose of a single medication and the diameter of the catheter. Generally, the diameter is 1 to 5 mm, the stroke is 1 to 30 mm, and the amount of liquid is 1 to 500 microliters at a time; preferably the diameter is 1 to 3 mm and the stroke is 5 ～20mm, 2～150μl of liquid at one time.

In the above technical solution, the time of relative rotation in the second direction is determined according to the natural breathing frequency of the human body, preferably 0.5 to 3 seconds, and more preferably 1 to 2 seconds.

Due to the application of the above technical solutions, the present invention has the following advantages compared with the prior art:

1. The present invention overcomes the prejudice of the prior art, and realizes the delivery of liquid medicine through reverse rotation on the premise of not instantaneously releasing the spring, and achieves unexpected technical effects.

2. Since there is no instantaneous release of the spring in the present invention, there is no psychological suggestion or physiological stress to the user. The use process is gentle, the operation is simple, and the user acceptance is higher.

The present invention is further described below with reference to the drawings and embodiments:

Embodiment 1: As shown in FIGS. 1 to 3, a liquid medicine delivery device has a liquid medicine container 1 and a medicine atomizing spray structure, and the medicine atomizing spray structure includes a conduit 4 cooperating with a liquid medicine container. It has an upper casing 2 and a lower casing 3 which can rotate relatively. The upper casing 2 is embedded with an upper rotating member 5. The lower casing 3 is embedded with a lower rotating member 6 and a spring 7 is provided. The inner walls of the component 5 and the lower rotating component 6 are respectively provided with sliding surfaces that cooperate with each other, so that the lower rotating component 6 moves away from the upper housing 2 and compresses the spring 7 when rotating relative to the upper rotating component 5 in the first direction.

The liquid medicine delivery device is provided with a stop limiter structure, as shown in FIGS. 4 to 7, in this embodiment, the stop limiter structure is that the sliding surface 8 of the upper rotating member 5 and the lower rotation A stop platform 9 and 14 are respectively provided at the proximal end of the sliding surface 13 of the component 6, the end behind the stop platform 9 forms a limit boss 10, and the end behind the stop platform 14 forms In another limiting boss 15, the stop platform on any one of the rotating parts cooperates with the limit boss on the other rotating part, so that the two limit bosses will conflict with each other after passing through the stop platform.

Referring to FIG. 8, when the upper rotating member 5 and the lower rotating member 6 are relatively rotated until the two limit bosses 10 and 15 are in contact with each other, the first stable position is reached, and at this time, the spring 7 (not shown) is in Compressed state; Fig. 9 is the state at the start of turning; Fig. 10 is the state of turning to the intermediate position; Fig. 11 is the turning stop state.

In the liquid drug delivery device, the relative rotation angle of the upper rotation mechanism 5 and the lower rotation mechanism 6 is determined according to the setting of the sliding surface. When only a pair of sliding surfaces is provided, the maximum relative rotation angle can be set to not exceed 360°; Correspondingly, when two pairs of sliding surfaces are provided, the relative rotation angle is preferably 160°-180°; and if four pairs of sliding surfaces are provided, the rotation angle is generally less than 90°. In this embodiment, two pairs of sliding surfaces are provided, and therefore, as shown in FIG. 11, the angle of rotation is limited to 177°.

Wherein, when the lower rotating member 6 rotates in the first direction until it is limited by the stop limiter structure, the catheter 4 moves downward accordingly; the lower rotating member 6 is opposite to the second direction opposite to the first direction When the upper rotating member 5 rotates, the spring 7 returns and the catheter 4 moves upward, thereby achieving the delivery of a trace amount of liquid medicine.

In this embodiment, by setting the stopper limit structure, the sliding surfaces 8 and 13 of the upper rotating member 5 and the lower rotating member 6 cannot be detached, so there is no situation where the spring 7 enters the free state instantaneously , There will be no large vibration or sound during use. When in use, the relative rotation of the upper rotating member 5 and the lower rotating member 6 realizes the delivery of the chemical solution. By controlling the rotation angle, the degree of compression of the spring and the vertical movement distance of the catheter can be controlled, so as to correspondingly control the liquid pumping volume or output volume, and realize the adjustment of the drug output dose.

The rotation in the second rotation direction in this embodiment may be manually driven by the user, or may be achieved by providing a reverse driving mechanism. The reverse drive mechanism can be set to adjust the rotation speed in time to ensure the output effect of the liquid medicine. The reverse drive mechanism may be a coil spring drive mechanism, or a motor as a power mechanism, and a gear or screw as a transmission mechanism. The motor here can be a permanent magnet linear stepper motor or a planetary gear motor. When the motor is used for driving, the rotation angle can be preset and controlled by the controller. At this time, the stop limit element structure plays a role in safety protection.

Embodiment 2: A liquid medicine delivery method, which is realized by using the liquid medicine delivery device of Embodiment 1, firstly rotating the lower rotating member 6 relative to the upper rotating member 5 in a first direction to a stop position, in the process the spring 7 is in a compressed state, the catheter 4 moves downward to suck liquid; then the lower rotating member 6 rotates relative to the upper rotating member 5 in a second direction opposite to the first direction, releasing the spring 7 while the catheter 4 moves upward The medicine is output from the container to form a jet or aerosol; the stroke of the catheter 4 is 5-20 mm, and the rotation time in the second direction is less than 5 seconds.

In the prior art, it is generally believed that in order to disperse the liquid medicine into droplets or aerosols in a very short time, it is necessary to use a press release to make the spring in a free state instantaneously. The present invention has unexpectedly discovered that using reverse rotation instead of instantaneous release can also achieve the desired effect.

In this embodiment, the stroke of the catheter 4 is related to the dose of a single medication and the diameter of the catheter. Generally, the diameter is 1 to 5 mm, the stroke is 1 to 30 mm, and the amount of liquid is 1 to 500 microliters at a time; preferably the diameter is 1 to 3 mm and the stroke 5～20mm, 2～150μl of liquid at one time. The amount of liquid applied at one time is more preferably 3 to 100 microliters.

In this embodiment, the time of relative rotation in the second direction is determined according to the natural breathing frequency of the human body, preferably 0.5 to 3 seconds, and more preferably 1 to 2 seconds.

Embodiment 3: A liquid drug delivery device, the main structure of which is the same as that of Embodiment 1, with reference to FIGS. 12 and 13, the difference of this embodiment is that a housing stop 11 is provided on the outer wall of the lower housing 3, An upper housing stop 12 is correspondingly arranged on the inner wall of the upper housing 2, a part of the upper housing 2 is sleeved on the lower housing 3, the lower housing stop 11 and the upper housing stop The block 12 cooperates to form the stop limit structure.

1: Liquid medicine container 2: Upper case 3: Lower case 4: Catheter 5: Upper rotating parts 6: Lower rotating part 7: Spring 8: Sliding surface 9: stop platform 10: limit boss 11: Lower housing stop 12: Upper housing stop 13: Sliding surface 14: stop platform 15: Limit boss

1 is an external view of the device of the first embodiment of the present invention; 2 is a schematic cross-sectional view in a state of FIG. 1; 3 is a schematic cross-sectional view of FIG. 1 in another state; 4 is a perspective view of the upper rotating member of the first embodiment; 5 is a bottom view of the upper rotating component of the first embodiment; 6 is a perspective view of a rotating member according to an embodiment; 7 is a plan view of a rotating member according to an embodiment; 8 to 11 are schematic diagrams of the fitted state of the sliding surfaces in the upper rotating member (removing the outer layer) and the lower rotating member (removing the outer layer); 12 is a structural diagram of a lower case in Embodiment 3; 13 is a structural diagram of an upper case in Embodiment 3.

1: Liquid medicine container

2: Upper case

3: Lower case

4: Catheter

5: Upper rotating parts

6: Lower rotating part

7: Spring

Claims (10)

A liquid medicine delivery device has a liquid medicine container and a medicine atomizing spray structure. The medicine atomizing spray structure contains a conduit matched with the liquid medicine container, and has an upper casing and a lower casing which can rotate relatively. An upper rotating component is embedded in the upper housing, a lower rotating component is embedded in the lower housing and a spring is provided, the upper rotating component and the inner wall of the lower rotating component are respectively provided with a sliding surface cooperating with each other, so that the lower rotating component Away from the upper housing and compress the spring when rotating relative to the upper rotating member in the first direction; It is characterized in that a stop limit element structure is provided, which limits the rotation amplitude when the lower rotating member rotates relative to the upper rotating member in the first direction to avoid the upper rotating member and the The sliding surface of the lower rotating member is disengaged, the duct moves with the lower rotating member in the up and down direction, and when the lower rotating member rotates in the first direction, the duct moves downward; the lower rotating member moves along the opposite side of the first direction When the two directions rotate relative to the upper rotating member, the spring returns and the catheter moves upward. The liquid drug delivery device according to claim 1, wherein at least one set of the sliding surfaces cooperating with each other is provided. The liquid drug delivery device according to claim 1, wherein the stopper is structured such that a stopper platform is provided at the proximal end of the sliding surface of the upper rotating member and the sliding surface of the lower rotating member, respectively A stop boss is formed at the end behind the stop platform, and the stop platform on any one of the rotating parts cooperates with the stop boss on the other rotating part, so that the two stop bosses pass through the stop platform After conflicting with the limit. The liquid drug delivery device according to claim 1, wherein a housing stopper is provided on the outer wall of the lower housing, and an upper housing stopper is correspondingly provided on the inner wall of the upper housing. A part is sleeved on the lower casing, and the lower casing stopper cooperates with the upper casing stopper to form the stop limit element structure. The liquid drug delivery device according to claim 1, wherein a reverse drive mechanism is provided, and after the upper rotating member and the lower rotating member are relatively rotated to the stop position in the first direction, the reverse driving mechanism drives both Relative rotation in the opposite direction. The liquid medicine delivery device according to claim 5, wherein the reverse driving mechanism is a coil spring driving mechanism. The liquid medicine delivery device according to claim 5, wherein the reverse driving mechanism is a motor as a power mechanism, and a gear or a screw as a transmission mechanism. A liquid medicine delivery method, wherein the liquid medicine delivery device according to claim 1 is implemented, firstly, a rotating member is rotated in a first direction relative to an upper rotating member to a stop position, during which a spring is in a compressed state, one The catheter moves downward to suck the liquid; then the lower rotating member rotates relative to the upper rotating member in a second direction opposite to the first direction, releasing the spring while the catheter moves upward causes the medicine to be output from the container to form a jet or aerosol ; The rotation time in the second direction is less than 5 seconds. The liquid medicine delivery method according to claim 8, wherein the amount of liquid to be fed at one time is 1 to 500 microliters, preferably 2 to 150 microliters, and more preferably 3 to 100 microliters. The liquid drug delivery method according to claim 8, wherein the relative rotation time in the second direction is 0.2 to 5 seconds, preferably 0.5 to 3 seconds, and more preferably 1 to 2 seconds.

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