WO2023108316A1 - Portable precise visual atomization delivery device based on surface acoustic wave technology - Google Patents

Abstract

A portable precise visual atomization delivery device based on surface acoustic wave technology, comprising a housing (1), an atomization chip (2), and a drug delivery apparatus. An atomization cavity (3) is provided in the housing (1), and the atomization cavity (3) has the upper portion connected to a breathing mask (4), and the lower portion connected to an air inlet pipe (5); the drug delivery apparatus comprises a drug storage portion, the drug storage portion comprising a storage bottle (6), a drug delivery valve (7), and a drug outlet pipe (8); the atomization chip (2) is used for atomizing a liquid medicine released by the drug delivery apparatus, and comprises a piezoelectric single crystal substrate (9), an interdigital transducer (10) provided on the piezoelectric single crystal substrate (9), a PCB (11) and a signal interface (12). A drug can generate quantitative, uniform and stable atomization by means of surface acoustic wave technology, a user can autonomously control an atomization amount and an atomization particle size by means of an external display and a control panel, thereby facilitating the visual observation of dosage and adjusting the dosage to control the apparatus.

Description

Portable, precise and visualized atomization delivery device based on surface acoustic wave technology technical field

The invention relates to a portable, precise and visualized atomization delivery device based on surface acoustic wave technology.

Background technique

Nebulization therapy is an important clinical treatment for various respiratory diseases. Nebulizing inhalation device is the key equipment of respiratory system drug delivery route. Due to the increasingly serious air pollution, the living air quality is getting worse and worse, and there are more and more patients with rhinitis and lung diseases. Some neurological diseases, including the recent inhaled new crown vaccine, generally require nebulization treatment, which is mainly through The compression nebulizer atomizes the liquid drug solution, allowing people to inhale the drug through normal breathing, and enter the respiratory tract, lungs and other diseased parts during the patient's breathing process, and finally achieve the goal of painless, rapid and effective treatment.

The current atomization therapy device cannot achieve accurate quantitative atomization, the liquid atomization effect is poor, and the spray droplets are large and uneven. It is difficult to achieve precise and stable fluid atomization and precise adjustment of mist administration.

Ultrasonic atomization plays an important role in eliminating inflammation, relieving bronchospasm, and improving ventilation. However, the ultrasonic atomization equipment used in clinical medicine is large in size and is not easy to carry or transport; The required power is large, the aerosol particles generated during atomization have a large diameter range and uneven distribution, and the heat generated during atomization is large, which easily causes the liquid to be atomized to evaporate. When the liquid to be atomized is a drug solvent, there will be a problem of drug precipitation.

Contents of the invention

In order to overcome the problems existing in the above-mentioned prior art, the present invention proposes a portable, precise and visualized atomization delivery device based on surface acoustic wave technology. Drugs can produce quantitative, uniform and stable atomization through surface acoustic wave technology. The unique display and control panel can independently realize the control of the atomization amount and atomization particle size, conveniently and intuitively observe the dosage and adjust the dosage to complete the control of the device.

The technical solution of the present invention to solve the above problems is: a portable accurate and visualized atomization delivery device based on surface acoustic wave technology, which is special in that:

Including housing, atomization chip, drug delivery device;

An atomization chamber is provided inside the housing, the upper part of the atomization chamber is connected to the breathing mask, and the lower part is connected to the air intake pipe;

The drug delivery device includes a drug storage part, and the drug storage part includes a storage bottle, a drug delivery valve, and a drug delivery tube;

The atomization chip is used to atomize the drug liquid released by the drug delivery device, including a piezoelectric single crystal substrate, an interdigital transducer, a PCB circuit board and a signal interface arranged on the piezoelectric single crystal substrate ; The piezoelectric single crystal substrate and the signal interface are located on the PCB circuit board, and the signal interface is connected to the interdigital transducer and the radio frequency signal generating device;

The drug delivery tube of the drug delivery device is attached to the upper surface of the piezoelectric single crystal substrate, and the interdigital transducer is driven by a radio frequency signal to generate a surface acoustic wave on the upper surface of the piezoelectric single crystal substrate, so that the piezoelectric The liquid on the upper surface of the single crystal substrate is atomized.

Further, a breathing detector and a control processor are also included;

The drug delivery valve is connected to the control processor, and the control processor outputs an opening signal or a closing signal to the drug delivery valve, and the drug delivery valve is opened or closed according to the opening signal or the closing signal;

The control processor outputs a decrease signal or an increase signal to the dosing valve, and the dosing valve decreases or increases the dosing amount of a preset proportion according to the decrease signal or the increase signal; The respiration detector is used to detect the respiration value and output it to the control processor; the control processor sends the detected current respiration value to the The dosing valve outputs an increase signal or a decrease signal.

Further, an LED display screen is provided on the housing; the LED display screen is connected to the control processor, and it is used to output setting data to the control processor and display the data output by the control processor; the device Certain data include the amount of medication used.

Further, the housing is provided with a manipulation panel for controlling the equipment.

Further, a charging port is provided on the housing; the charging port is connected to a built-in power supply.

Further, when the supply flow rate of the liquid delivered to the surface of the piezoelectric single crystal substrate by the drug delivery device is consistent with the atomization rate of the liquid on the upper surface of the piezoelectric single crystal substrate, the continuous flow of the liquid on the surface of the piezoelectric single crystal substrate is realized. Atomization.

Further, the adjustment of the interdigital transducer can adjust the atomization rate of the liquid on the upper surface of the piezoelectric single crystal substrate according to the radio frequency signal power of the loaded radio frequency signal generating device.

Further, a flow meter is provided on the medicine outlet pipe for measuring the amount of medicine used.

Further, an air pump is also included, the air inlet of the air pump is connected with the air inlet pipe, and the air outlet of the air pump is connected with the atomization chamber.

Further, the breathing mask is detachably connected to the atomization chamber, and the air pump is controlled by a control processor.

Advantages of the present invention:

The atomization device based on the surface acoustic wave provided by the example of the present invention, compared with ultrasonic atomization:

1. The particle size of the aerosol generated during atomization is smaller and the particles are more uniform. When the droplet size is 2-5 μm, the efficiency of lung drug therapy reaches the maximum, and it is convenient for users to inhale into the lower part of the respiratory tract or lungs, depositing Therefore, these monodisperse micron-sized spray droplets are extremely useful as drug-carrying vehicles for pulmonary drug delivery.

2. When the interdigital transducer generates surface acoustic waves, the excitation frequency is 10kHz to 1MHz, which is higher than the frequency required for ultrasonic atomization. The power is at most the ultrasonic atomizer using the Langevin vibrator and the one-way zirconium titanate 1/10 of the power required by the component piston nebulizer, suitable for medical and clinical applications.

3. Based on the surface acoustic wave atomization method, the heat generated on the surface of the piezoelectric single crystal substrate is less, and the problem of drug precipitation is not easy to occur.

4. The atomization technology does not require nozzles or orifices, the device is simplified, and the cost is lower than other atomization technologies and the reliability is increased.

Description of drawings

Fig. 1 is a schematic diagram of the present invention;

Fig. 2 is a schematic diagram of the internal structure of the present invention;

Fig. 3 is a schematic structural diagram of the atomization chip in Fig. 1 .

Among them: 1. Housing, 2. Atomization chip, 3. Atomization chamber, 4. Respiratory mask, 5. Air intake pipe, 6. Storage bottle, 7. Drug delivery valve, 8. Drug delivery tube, 9. Piezoelectric Single crystal substrate, 10. Interdigital transducer, 11. PCB circuit board, 12. Signal interface, 13. Respiratory detector, 14. Control processor, 15. LED display, 17. Control panel, 18. Charging port , 19, built-in power supply, 20, radio frequency signal generating device, 21, flow meter, 22, air pump.

Detailed ways

In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments It is some embodiments of the present invention, but not all of them. Based on the implementation manners in the present invention, all other implementation manners obtained by persons of ordinary skill in the art without making creative efforts belong to the scope of protection of the present invention. Accordingly, the following detailed description of the embodiments of the invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely represents selected embodiments of the invention.

Surface acoustic wave (SAW) atomization is an emerging microfluid atomization method in recent years. It has non-contact continuous and stable atomization, small aerosol particle size and uniform distribution, low driving power consumption, high atomization efficiency, and low Features such as heat generation, easy integration and miniaturization are a direction for the future development of atomizers.

Referring to Fig. 1 and Fig. 2, the present invention proposes a portable accurate and visualized atomization delivery device based on surface acoustic wave technology, including a housing 1, an atomization chip 2, and a drug delivery device. The casing 1 is provided with an atomizing chamber 3 , the upper part of the atomizing chamber 3 is connected to the breathing mask 4 , and the lower part is connected to the air intake pipe 5 .

The drug delivery device includes a drug storage part, and the drug storage part includes a storage bottle 6 , a drug delivery valve 7 and a drug delivery tube 8 . The atomizing chip 2 is connected with the drug outlet tube 8 for atomizing the drug solution released by the drug delivery device.

Referring to Fig. 3, the atomizing chip 2 includes a piezoelectric single crystal substrate 9, and an interdigital transducer 10, a PCB circuit board 11 and a signal interface 12 arranged on the piezoelectric single crystal substrate 9; Electric single crystal matrix 9 and signal interface 12 are arranged on described PCB circuit board 11, and described signal interface 12 connects interdigital transducer 10 and radio frequency signal generator 20; On the upper surface of the piezoelectric single crystal substrate 9, the interdigital transducer 10 is driven by a radio frequency signal to generate a surface acoustic wave on the upper surface of the piezoelectric single crystal substrate 9, so that the liquid on the upper surface of the piezoelectric single crystal substrate 9 Fogging occurs.

The technical principle of the present invention is: when the SAW excited by the interdigital transducer of the atomization chip is in contact with the microfluid placed on the side of the piezoelectric substrate, the energy carried by the SAW will diffract into it at a specific angle in the form of a surface acoustic wave. The liquid produces an acoustic flow coupling effect and forms capillary waves on the surface of the microfluid. When the inertial force accumulated by the surface capillary wave is sufficient to overcome the surface tension and viscous force of the microfluid itself, atomization begins to occur. Due to the higher frequency of SAW, the spray droplets produced will be smaller and more uniform. Ideal for generating micron-sized droplets without any moving parts or nozzles.

As a preferred embodiment of the present invention, referring to FIG. 2 , the device of the present invention further includes a breathing detector 13 and a control processor 14 . The drug delivery valve 7 is connected to the control processor 14, and the control processor 14 outputs an opening signal or a closing signal to the drug delivery valve 7, and the drug delivery valve 7 is opened or closed according to the opening signal or the closing signal ; The control processor 14 outputs a reduction signal or an increase signal to the drug delivery valve 7, and the drug delivery valve 7 reduces the dosage of the preset ratio or increases the preset ratio according to the reduction signal or the increase signal The amount of medicine administered; the respiration detector 13 is used to detect the respiration value and output it to the control processor 14; the control processor 14 corresponds to the detected The current respiratory volume value outputs an increase signal or a decrease signal to the dosing valve 7 .

As a preferred embodiment of the present invention, referring to Fig. 1, the housing 1 is provided with an LED display screen 15; the LED display screen 15 is connected with the control processor 14, and it is used to output Set the data and display the data output by the control processor 14; the set data includes the usage amount of the medicine.

As a preferred embodiment of the present invention, referring to FIG. 1 , the housing 1 is provided with a control panel 17 for controlling the opening and closing of the device.

As a preferred embodiment of the present invention, the housing 1 is provided with a charging port 18; the charging port 18 is connected to a built-in power supply 19, and the built-in power supply 19 enables the device to be carried outside.

As a preferred embodiment of the present invention, when the delivery rate of the liquid delivered to the surface of the piezoelectric single crystal substrate 9 by the drug delivery device is consistent with the atomization rate of the liquid on the upper surface of the piezoelectric single crystal substrate 9, the piezoelectric The surface of the single crystal substrate 9 realizes continuous atomization of the liquid.

As a preferred embodiment of the present invention, adjusting the interdigital transducer 10 according to the RF signal power of the loaded RF signal generating device 20 can adjust the liquid atomization rate on the upper surface of the piezoelectric single crystal substrate 9 .

As a preferred embodiment of the present invention, the medicine outlet pipe 8 is provided with a flow meter 21 for measuring the amount of medicine used. The value measured by the flow meter 21 is directly displayed on the LED display screen 15 .

As a preferred embodiment of the present invention, an air pump 22 is also included, the air inlet of the air pump 22 is connected to the air inlet pipe 5 , and the air outlet of the air pump 22 is connected to the atomizing chamber 3 . The air pump 22 provides pressure to the incoming air, so that the air enters the atomizing chamber 3 under pressure, and the atomized medicine is sent into the breathing mask 4 .

As a preferred embodiment of the present invention, the breathing mask 4 is detachably connected to the atomization chamber 3 for easy replacement. The air pump 22 is controlled by the control processor 14, and the air pump 22 is turned on after the control processor 14 is turned on. The breathing mask 4 is a disposable mask, which can be disassembled and processed after being used once to avoid cross-infection.

Example

Referring to FIGS. 1-3 , a portable accurate and visualized atomization delivery device based on surface acoustic wave technology includes a housing 1 , a breathing detector 13 and a control processor 14 . Inside the casing 1 is an atomizing chip 2 , a drug delivery device, and an atomizing chamber 3 . The upper part of the atomization chamber 3 is connected to the breathing mask 4, and the lower part is connected to the intake pipe 5 through the air pump 22.

The drug delivery device includes a drug storage part, and the drug storage part includes a storage bottle 6 , a drug delivery valve 7 and a drug delivery tube 8 . The atomizing chip 2 is connected with the drug outlet tube 8 for atomizing the drug solution released by the drug delivery device. The air pump 22 provides pressure to the incoming air, so that the air enters the atomizing chamber 3 under pressure, and the atomized medicine is sent into the breathing mask 4 .

Referring to Fig. 3, the atomizing chip 2 includes a piezoelectric single crystal substrate 9, and an interdigital transducer 10, a PCB circuit board 11 and a signal interface 12 arranged on the piezoelectric single crystal substrate 9; Electric single crystal matrix 9 and signal interface 12 are arranged on described PCB circuit board 11, and described signal interface 12 connects interdigital transducer 10 and radio frequency signal generator 20; On the upper surface of the piezoelectric single crystal substrate 9, the interdigital transducer 10 is driven by a radio frequency signal to generate a surface acoustic wave on the upper surface of the piezoelectric single crystal substrate 9, so that the liquid on the upper surface of the piezoelectric single crystal substrate 9 Fogging occurs.

The drug delivery valve 7 is connected to the control processor 14, and the control processor 14 outputs an opening signal or a closing signal to the drug delivery valve 7, and the drug delivery valve 7 is opened or closed according to the opening signal or the closing signal ; The control processor 14 outputs a reduction signal or an increase signal to the drug delivery valve 7, and the drug delivery valve 7 reduces the dosage of the preset ratio or increases the preset ratio according to the reduction signal or the increase signal The amount of medicine administered; the respiration detector 13 is used to detect the respiration value and output it to the control processor 14; the control processor 14 corresponds to the detected The current respiratory volume value outputs an increase signal or a decrease signal to the dosing valve 7 . When the delivery rate of the liquid delivered to the surface of the piezoelectric single crystal substrate 9 by the drug delivery device is consistent with the atomization rate of the liquid on the upper surface of the piezoelectric single crystal substrate 9, the continuous flow of liquid on the surface of the piezoelectric single crystal substrate 9 is realized. Atomization.

As a preferred embodiment of the present invention, adjusting the interdigital transducer 10 according to the RF signal power of the loaded RF signal generating device 20 can adjust the liquid atomization rate on the upper surface of the piezoelectric single crystal substrate 9 .

The side of the housing 1 is provided with an LED display 15 and a control panel 17 , and a charging port 18 is provided on the lower side. The LED display screen 15 is connected with the control processor 14, and it is used to output setting data to the control processor 14 and display the data output by the control processor 14; the setting data includes the usage amount of the medicine. The control panel 17 is used to control the opening and closing of the equipment. The charging port 18 is connected to a built-in power supply 19, and the built-in power supply 19 enables the device to be carried outside.

A flow meter 21 is provided on the medicine outlet pipe 8 for measuring the amount of medicine used. The value measured by the flow meter 21 is directly displayed on the LED display screen 15 . The breathing mask 4 is detachably connected to the atomization chamber 3, which is convenient for replacement. The air pump 22 is controlled by the control processor 14, and the air pump 22 is turned on after the control processor 14 is turned on. The breathing mask 4 is a disposable mask, which can be disassembled and processed after being used once to avoid cross-infection.

The above description is only an embodiment of the present invention, and is not intended to limit the protection scope of the present invention. Any equivalent structure or equivalent process conversion made by using the description of the present invention and the contents of the accompanying drawings, or directly or indirectly used in other related The system field is equally included in the scope of protection of the present invention.

Claims (10)

1. A portable accurate and visualized atomization delivery device based on surface acoustic wave technology, characterized in that:

   It includes a casing (1), an atomization chip (2), and a drug delivery device;

   The shell (1) is provided with an atomizing chamber (3), the upper part of the atomizing chamber (3) is connected to the breathing mask (4), and the lower part is connected to the air intake pipe (5);

   The drug delivery device includes a drug storage part, and the drug storage part includes a storage bottle (6), a drug delivery valve (7), and a drug delivery tube (8);

   The atomization chip (2) is used to atomize the drug liquid released by the drug delivery device, and includes a piezoelectric single crystal substrate (9) and an interdigital switch arranged on the piezoelectric single crystal substrate (9). Energy device (10), PCB circuit board (11) and signal interface (12); Described piezoelectric single crystal substrate (9) and signal interface (12) are located on the described PCB circuit board (11), and described signal The interface (12) connects the interdigital transducer (10) and the radio frequency signal generating device (20);

   The drug delivery tube (8) of the drug delivery device is attached to the upper surface of the piezoelectric single crystal substrate (9), and the interdigital transducer (10) is driven by a radio frequency signal on the piezoelectric single crystal substrate ( 9) Surface acoustic waves are generated on the upper surface to atomize the liquid on the upper surface of the piezoelectric single crystal substrate (9).
2. According to claim 1, a portable accurate and visualized atomization delivery device based on surface acoustic wave technology is characterized in that:

   It also includes a breathing detector (13) and a control processor (14);

   The drug delivery valve (7) is connected to the control processor (14), and the control processor (14) outputs an opening signal or a closing signal to the drug delivery valve (7), and the drug delivery valve (7) ) is turned on or off according to the opening signal or the closing signal;

   The control processor (14) outputs a decrease signal or an increase signal to the dosing valve (7), and the dosing valve (7) reduces the dosing amount of a preset ratio or Increase the preset proportion of the drug dose; the breath detector (13) is used to detect the breath value, and output to the control processor (14); the control processor (14) according to the prestored breath value and The drug dose value comparison table outputs an increase signal or a decrease signal to the drug dose valve (7) corresponding to the detected current respiratory value.
3. A portable precise visualization atomization delivery device based on surface acoustic wave technology according to claim 2, characterized in that:

   The housing (1) is provided with an LED display (15);

   The LED display screen (15) is connected with the control processor (14), and it is used to output setting data to the control processor (14) and display the data output by the control processor (14); the setting data including drug use.
4. According to claim 3, a portable precise visualization atomization delivery device based on surface acoustic wave technology, characterized in that:

   The housing (1) is provided with a manipulation panel (17) for controlling the equipment.
5. A portable precise visualization atomization delivery device based on surface acoustic wave technology according to claim 4, characterized in that:

   The housing (1) is provided with a charging port (18); the charging port (18) is connected to a built-in power supply (19).
6. According to claim 5, a portable precise visualization atomization delivery device based on surface acoustic wave technology, characterized in that:

   When the delivery rate of the liquid delivered to the surface of the piezoelectric single crystal substrate (9) by the drug delivery device is consistent with the atomization rate of the liquid on the upper surface of the piezoelectric single crystal substrate (9), the piezoelectric single crystal substrate (9) ) surface to achieve continuous atomization of the liquid.
7. A portable precise visualization atomization delivery device based on surface acoustic wave technology according to claim 6, characterized in that:

   The adjustment of the interdigital transducer (10) can adjust the liquid atomization rate on the upper surface of the piezoelectric single crystal substrate (9) according to the radio frequency signal power of the loaded radio frequency signal generator (20).
8. According to claim 7, a portable precise visualization atomization delivery device based on surface acoustic wave technology, characterized in that:

   A flow meter (21) is provided on the medicine outlet pipe (8) for measuring the amount of medicine used.
9. According to claim 8, a portable precise visualization atomization delivery device based on surface acoustic wave technology, characterized in that:

   An air pump (22) is also included, the air inlet of the air pump (22) is connected to the air inlet pipe (5), and the air outlet of the air pump (22) is connected to the atomization chamber (3).
10. According to claim 9, a portable precise visualization atomization delivery device based on surface acoustic wave technology, characterized in that:

    The breathing mask (4) is detachably connected to the atomization chamber (3), and the air pump (22) is controlled by a control processor (14).

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