TWI708622B - Liquid medicine delivery device and medicine delivery method - Google Patents

Abstract

The invention discloses a liquid drug delivery device, which has a relatively rotatable upper shell and a lower shell, the upper shell is embedded with an upper rotating part, the lower shell is embedded with a lower rotating part and is provided with a spring, the upper rotating part and the lower rotating part The inner walls of the components are respectively provided with sliding surfaces that cooperate with each other, so that the lower rotating component moves away from the upper shell and compresses the spring when rotating relative to the upper rotating component in the first direction; it is characterized in that: a stop and limit element structure is provided to rotate downward When the component rotates in the first direction relative to the upper rotating component, the rotation range is limited. When the lower rotating component rotates in the first direction, the catheter moves downward; the lower rotating component rotates relative to the upper rotating component in a second direction opposite to the first direction When, the spring returns and the catheter moves up. The invention has no instant release of the spring, and the use process is relatively gentle.

Description

Liquid medicine delivery device and medicine delivery method

The invention relates to a medical device, in particular to a liquid drug delivery device for quantitative drug delivery, and a drug delivery method adopted by it.

Nebulized inhalation therapy is the use of an atomizing device to disperse the medicine into tiny droplets or particles, which are suspended in the air and enter the respiratory tract and lungs to achieve the purpose of cleaning the airway, humidifying the airway, local treatment and systemic treatment. Common atomization devices include manual spray atomizers, metered dose inhalers, dry powder inhalers and so on. Among them, metered-dose inhalers are popular because they have the advantages of quantitative, simple operation, easy to carry, ready to use, no need for regular disinfection, and no cross-infection problems in the hospital. A metered-dose inhaler is usually composed of a sealed storage tank, an inhalation tube, a metered valve, and a nozzle. One method is to use a spring as an energy source to achieve drug delivery and atomized injection.

For example, US Patent Publication No. US2009/0114215A1 discloses a nebulizer with a built-in replaceable liquid medicine container, an inhalation tube movable relative to the liquid medicine container, a one-way valve, a pressure chamber, and a spray nozzle; The carburetor has a relatively rotatable upper shell and a lower shell, the upper shell is embedded with an upper rotating part, the lower shell is sleeved with a lower rotating part and a spring, and the inner walls of the upper rotating part and the lower rotating part are respectively provided with The sliding surfaces cooperate with each other so that when rotating in one direction, the lower rotating part is away from the upper rotating part and compresses the spring; a locking part is provided, when the lower rotating part is separated from the sliding surface of the upper rotating part, the locking part faces the lower rotating part Limit. When in use, make the upper and lower parts rotate relative to each other so that the lower rotating part compresses the spring while the suction pipe moves downward. The liquid enters the pressure chamber through the one-way valve. When the sliding surfaces of the upper and lower rotating parts are separated, the locking part Limit the lower rotating part; when spraying, press the button to release the lower rotating part. Under the elastic force of the spring, the lower rotating part quickly resets, and the suction pipe moves up synchronously. The kinetic energy released by the spring makes the liquid medicine quickly output and form a jet Or aerosol.

The above-mentioned structure is a typical structure of a liquid drug delivery device with a spring as an energy source. When applied in such as soft atomizers, needle-free syringes, nasal sprayers, etc., this type of structure generally uses a push-type release button as the Trigger devices, because those skilled in the art generally believe that such devices require relatively large energy to disperse the liquid drug into droplets or aerosols in a very short time to enter and be absorbed by the human body, so pressing is required The type release makes the spring instantly in a free state. However, when the trigger device is activated, it is often accompanied by obvious vibration or sound, which produces unhealthy psychological hints or physiological stress to the user, resulting in a decrease in the user’s acceptance of the medication device, especially nebulized inhalation that needs to be used with breathing In the device, it is required to enter the inhalation state at the same time as the drug is released, and the physiological stress response will make it difficult for the user to control the breathing loop, resulting in an adverse stress response. Since this type of drug delivery device is generally used for chronic obstructive pneumonia or diabetes insulin treatment, it has the characteristics of long-term and high-frequency medication. The user's adaptability to the drug delivery device directly affects whether the treatment can be implemented smoothly. It has formed certain obstacles for users to receive such drug delivery devices and use drugs correctly over a long period of time.

Therefore, it is necessary to improve the triggering method of this type of liquid drug delivery device to avoid adverse physiological stress on the user and improve the user's acceptance.

The purpose of the present invention is to provide a liquid drug delivery device, which solves the problems of vibration and sound when triggered in existing devices through structural improvements; another purpose of the present invention is to provide a liquid drug delivery method matched with such a delivery device.

In order to achieve the above-mentioned object of the invention, the technical solution adopted by the present invention is: a liquid medicine delivery device having a liquid medicine container and a medicine atomization spray structure, and the medicine atomization spray structure contains a tube matched with the liquid medicine container, It has a relatively rotatable upper shell and a lower shell, the upper shell is embedded with an upper rotating part, the lower shell is embedded with a lower rotating part and is provided with a spring, and the inner walls of the upper rotating part and the lower rotating part are respectively It is provided with a sliding surface that cooperates with each other, so that the lower rotating part moves away from the upper housing and compresses the spring when rotating relative to the upper rotating part in the first direction; a stop-limiting element structure is provided, and the stop-stop The element structure limits the rotation amplitude when the lower rotating part rotates relative to the upper rotating part in the first direction to prevent the sliding surface of the upper rotating part and the lower rotating part from being separated, and the catheter follows the lower rotating part along the up and down direction Movement, when the lower rotating part rotates in a first direction, the catheter moves down; when the lower rotating part rotates relative to the upper rotating part in a second direction opposite to the first direction, the spring is reset and the catheter moves up.

In the above technical solution, by providing the stop and limit element structure, the sliding surface of the upper rotating part and the lower rotating part cannot be separated, so there is no situation in which the spring enters a free state instantaneously, and it will not appear during use. Large vibration or sound. When in use, the upper rotating part and the lower rotating part rotate relative to each other to realize the liquid medicine delivery. By controlling the rotation angle, the compression degree of the spring and the vertical movement distance of the catheter can be controlled, so as to correspondingly control the liquid pumping volume or output volume, and realize the adjustment of the drug output dose.

In the above technical solution, the relative rotation angle of the upper rotation mechanism and the lower rotation mechanism is determined by the setting of the sliding surfaces. When only a pair of sliding surfaces is provided, the maximum relative rotation angle can be set to not exceed 360°; accordingly, When there are two pairs of sliding surfaces, the relative rotation angle of rotation is preferably 160°～180°; and if there are four pairs of sliding surfaces, the rotation angle is generally less than 90°.

In the above technical solution, the stop and limit element structure is that a stop platform is respectively provided at the sliding surface of the upper rotating component and the proximal end of the sliding surface of the lower rotating component, and a stop platform is provided behind the stop platform. A limit boss is formed at the end, and the stop platform on any one rotating part is matched with the limit boss on the other rotating part, so that the two limit bosses conflict with each other after passing the stop platform. .

Alternatively, a lower housing stop is provided on the outer wall of the lower housing, an upper housing stop is correspondingly provided on the inner wall of the upper housing, and a part of the upper housing is sleeved on the lower housing, The lower housing stopper cooperates with the upper housing stopper to form the stop and limit element structure.

In a further technical solution, a reversing drive mechanism is provided. After the upper rotating component and the lower rotating component are relatively rotated in the first direction to the stop position, the reversing drive mechanism drives the two to relatively rotate in the opposite direction.

The reverse drive mechanism is a coil spring drive mechanism. Alternatively, the reverse drive mechanism uses a motor as a power mechanism, and a gear or screw as a transmission mechanism. The motor here can be a permanent magnet linear stepper motor or a planetary gear motor. When a motor is used for driving, the rotation angle can be preset and controlled by the controller. At this time, the stop limit element structure plays a role of safety protection. The reversal driving mechanism can also be activated by means of a data sensor to detect the strength of the breathing air flow, for example, the driving motor is started when the breathing air flow reaches a set threshold.

In order to achieve another objective of the present invention, a liquid drug delivery method is provided, which is implemented by using the above-mentioned liquid drug delivery device. First, the lower rotating member is rotated in a first direction relative to the upper rotating member to a stop position, and in the process When the spring is in a compressed state, the catheter moves downward to suck the liquid; then the lower rotating part is rotated in a second direction opposite to the first direction relative to the upper rotating part, and the spring is released while the catheter moves upward to make the medicine from the container The middle output forms a jet or aerosol; the stroke of the catheter is 5-20mm, and the time to rotate in the second direction is less than 5 seconds.

In the prior art, it is generally believed that in order to disperse the liquid medicine into droplets or aerosol form in a very short time, it is necessary to adopt a pressing release to make the spring in a free state instantaneously. The present invention has unexpectedly found that using reverse rotation instead of instantaneous release can also achieve the desired effect.

In the above technical solution, the stroke of the catheter is related to the single dose and the diameter of the catheter. Generally, the diameter is 1 to 5 mm, the stroke is 1 to 30 mm, and the fluid volume is 1 to 500 microliters; preferably, the diameter is 1 to 3 mm, and the stroke is 5 ～20mm, the volume of liquid is 2～150 microliters at a time.

In the above technical solution, the time for the relative rotation in the second direction is determined according to the natural respiratory frequency of the human body, and is preferably 0.5 to 3 seconds, more preferably 1 to 2 seconds.

Due to the application of the above technical solutions, the present invention has the following advantages compared with the prior art:

1. The present invention overcomes the prejudice of the prior art, and realizes liquid drug delivery through reverse rotation without instantaneous release of the spring, and has achieved unexpected technical effects.

2. Since there is no instantaneous release of the spring in the present invention, it will not produce psychological hints or physiological stress to the user, the use process is relatively gentle, the operation is simple, and the user's acceptance is higher.

The present invention will be further described below in conjunction with the drawings and embodiments:

Embodiment 1: As shown in Figs. 1 to 3, a liquid medicine delivery device has a liquid medicine container 1, a medicine atomized spray structure, and the medicine atomized spray structure contains a tube 4 matched with the liquid medicine container. It has a relatively rotatable upper shell 2 and a lower shell 3. The upper shell 2 is embedded with an upper rotating part 5, and the lower shell 3 is embedded with a lower rotating part 6 and is provided with a spring 7. The inner wall of the component 5 and the lower rotating component 6 are respectively provided with sliding surfaces that cooperate with each other, so that the lower rotating component 6 moves away from the upper housing 2 and compresses the spring 7 when rotating relative to the upper rotating component 5 in the first direction.

The liquid drug delivery device is provided with a stop and limit element structure, as shown in FIGS. 4 to 7. In this embodiment, the stop and limit element structure is that the sliding surface 8 and the lower rotation of the upper rotating component 5 The proximal end of the sliding surface 13 of the component 6 is provided with a stop platform 9 and 14 respectively. The end behind the stop platform 9 constitutes a limit boss 10, and the end behind the stop platform 14 constitutes For the other limiting boss 15, the stop platform on any one of the rotating parts is matched with the limiting boss on the other rotating part, so that the two limiting bosses conflict with each other after passing the stop platform.

Referring to Figure 8, when the upper rotating part 5 and the lower rotating part 6 are relatively rotated until the two limit bosses 10 and 15 conflict with each other, the first stable position is reached. At this time, the spring 7 (not shown) is in Compressed state; Figure 9 is the state at the beginning of the rotation; Figure 10 shows the state of turning to the intermediate position; Figure 11 is the state of stopping the rotation.

In the liquid drug delivery device, the relative rotation angle of the upper rotation mechanism 5 and the lower rotation mechanism 6 is determined according to the setting of the sliding surface. When only a pair of sliding surfaces are provided, the maximum relative rotation angle can be set to not exceed 360°; Correspondingly, when two pairs of sliding surfaces are provided, the relative rotation angle of rotation is preferably 160°-180°; and if four pairs of sliding surfaces are provided, the rotation angle is generally less than 90°. In this embodiment, two pairs of sliding surfaces are provided. Therefore, as shown in FIG. 11, the rotation angle is limited to 177°.

Wherein, when the lower rotating part 6 rotates in the first direction to be restricted by the stop and limiting element structure, the catheter 4 moves downward accordingly; the lower rotating part 6 faces in a second direction opposite to the first direction When the upper rotating component 5 rotates, the spring 7 is reset and the catheter 4 moves upward, thereby realizing the delivery of a small amount of liquid medicine.

In this embodiment, by setting the stop and limit element structure, the sliding surfaces 8 and 13 of the upper rotating part 5 and the lower rotating part 6 cannot be separated, so there is no situation where the spring 7 enters a free state instantly , There will be no big vibration or sound during use. When in use, the upper rotating part 5 and the lower rotating part 6 are rotated relative to each other in opposite directions to realize the liquid medicine delivery. By controlling the rotation angle, the compression degree of the spring and the vertical movement distance of the catheter can be controlled, so as to correspondingly control the liquid pumping volume or output volume, and realize the adjustment of the drug output dose.

The rotation in the second rotation direction in this embodiment can be manually driven by the user, or can be achieved by providing a reverse driving mechanism. The reversal driving mechanism is provided, and the rotation speed can be adjusted in time to ensure the output effect of the liquid medicine. The reverse drive mechanism can be a coil spring drive mechanism, or a motor as a power mechanism, and a gear or screw as a transmission mechanism. The motor here can be a permanent magnet linear stepper motor or a planetary gear motor. When a motor is used for driving, the rotation angle can be preset and controlled by the controller. At this time, the stop limit element structure plays a role of safety protection.

Embodiment 2: A liquid drug delivery method is implemented by using the liquid drug delivery device of the first embodiment. First, the lower rotating member 6 is rotated in a first direction relative to the upper rotating member 5 to a stop position. During this process, the spring 7 is in a compressed state, the tube 4 moves downward to suck the liquid; then the lower rotating part 6 is rotated in a second direction opposite to the first direction relative to the upper rotating part 5, and the spring 7 is released while the tube 4 moves up The medicine is output from the container to form a jet or aerosol; the stroke of the catheter 4 is 5-20 mm, and the time to rotate in the second direction is less than 5 seconds.

In the prior art, it is generally believed that in order to disperse the liquid medicine into droplets or aerosol form in a very short time, it is necessary to adopt a pressing release to make the spring in a free state instantaneously. The present invention has unexpectedly found that using reverse rotation instead of instantaneous release can also achieve the desired effect.

In this embodiment, the stroke of the catheter 4 is related to the single dose and the diameter of the catheter. Generally, the diameter is 1 to 5 mm, the stroke is 1 to 30 mm, and the fluid volume is 1 to 500 microliters; preferably, the diameter is 1 to 3 mm. 5～20mm, the amount of liquid filling is 2～150 microliters. More preferably, the amount of liquid at one time is 3-100 microliters.

In this embodiment, the relative rotation time in the second direction is determined according to the natural breathing frequency of the human body, and is preferably 0.5 to 3 seconds, and more preferably, 1 to 2 seconds.

The third embodiment: a liquid drug delivery device, the main structure of which is the same as that of the first embodiment, referring to Figures 12 and 13. The difference of this embodiment is that a housing stop 11 is provided on the outer wall of the lower housing 3. An upper housing stop 12 is correspondingly provided on the inner wall of the upper housing 2, a part of the upper housing 2 is sleeved on the lower housing 3, the lower housing stop 11 and the upper housing stop 12 The blocks 12 cooperate to form the stop and limit element structure.

1: Liquid medicine container 2: Upper shell 3: lower shell 4: Catheter 5: Upper rotating part 6: Lower rotating part 7: Spring 8: Sliding surface 9: Stop platform 10: Limiting boss 11: Lower housing stop 12: Upper shell stop 13: Sliding surface 14: stop platform 15: Limiting boss

Fig. 1 is an external view of the device according to the first embodiment of the present invention; Figure 2 is a schematic cross-sectional view of Figure 1 in a state; Figure 3 is a schematic cross-sectional view of Figure 1 in another state; Figure 4 is a perspective view of the upper rotating part of the first embodiment; Figure 5 is a bottom view of the upper rotating part of the first embodiment; Figure 6 is a perspective view of a rotating part of the first embodiment; Figure 7 is a top view of the rotating part of the first embodiment; Figures 8 to 11 are schematic views of the mating state of the sliding surfaces in the upper rotating part (with the outer layer removed) and the lower rotating part (with the outer layer removed); Figure 12 is a structural diagram of the lower housing in the third embodiment; Figure 13 is a structural diagram of the upper housing in the third embodiment.

1: Liquid medicine container

2: Upper shell

3: lower shell

4: Catheter

5: Upper rotating part

6: Lower rotating part

7: Spring

Claims (10)

A liquid medicine delivery device has a liquid medicine container and a medicine atomization spray structure. The medicine atomization spray structure contains a tube matched with the liquid medicine container, and has a relatively rotatable upper shell and a lower shell. The upper shell is embedded with an upper rotating part, the lower shell is embedded with a lower rotating part and is provided with a spring, the upper rotating part and the inner wall of the lower rotating part are respectively provided with a sliding surface that cooperates with each other, so that the lower rotating part When rotating relative to the upper rotating part in the first direction, move away from the upper housing and compress the spring; it is characterized in that a stop and limit element structure is provided, and the stop and limit element structure is arranged along the first When the direction is relative to the upper rotating part, the rotation amplitude is limited to prevent the sliding surface of the upper rotating part and the lower rotating part from being separated. The catheter moves in the up and down direction with the lower rotating part. When rotating in one direction, the catheter moves downward; when the lower rotating part rotates relative to the upper rotating part in a second direction opposite to the first direction, the spring returns and the catheter moves upward. The liquid drug delivery device according to claim 1, wherein at least one set of the sliding surfaces that cooperate with each other is provided. The liquid medicine delivery device according to claim 1, wherein the stop limit element structure is that a stop platform is respectively provided at the proximal end of the sliding surface of the upper rotating component and the sliding surface of the lower rotating component, The end of the stop platform constitutes a limit boss, and the stop platform on any one of the rotating parts is matched with the limit boss on the other rotating part, so that the two limit bosses pass through the stop After the platform conflicts with the limits. The liquid medicine delivery device according to claim 1, wherein a lower housing stop is provided on the outer wall of the lower housing, and an upper housing stop is correspondingly provided on the inner wall of the upper housing, the upper housing A part of is sleeved on the lower shell, and the lower shell stopper cooperates with the upper shell stopper to form the stop and limit element structure. The liquid medicine delivery device according to claim 1, wherein a reverse driving mechanism is provided, and after the upper rotating part and the lower rotating part are relatively rotated in the first direction to the stop position, the reverse driving mechanism drives both Relative rotation in the opposite direction. The liquid medicine delivery device according to claim 5, wherein the reverse driving mechanism is a coil spring driving mechanism. The liquid medicine delivery device according to claim 5, wherein the reverse driving mechanism uses a motor as a power mechanism and a gear or screw as a transmission mechanism. A liquid medicine delivery method, wherein the liquid medicine delivery device as in claim 1 is used. First, the lower rotating part is rotated in a first direction relative to the upper rotating part to a stop position, and a spring is in a compressed state during this process. The catheter moves downward to suck the liquid; and then the lower rotating member is rotated in a second direction opposite to the first direction relative to the upper rotating member, and the spring is released while the catheter moves upward so that the medicine is output from the container to form a jet or aerosol ; The time to rotate in the second direction is less than 5 seconds. The liquid medicine delivery method according to claim 8, wherein the liquid volume is 1 to 500 microliters at a time. The liquid medicine delivery method according to claim 8, wherein the relative rotation time in the second direction is 0.2-5 seconds.

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