TW201902451A - a dispersion containing a pigment or a dispersant for powder - Google Patents

Abstract

To provide: a dispersion liquid containing a pigment or powder, which is able to be prevented from separation and sedimentation of the pigment or the like over time; and a dispersant. A dispersion liquid which contains: a dispersant for pigments or powders, which is formed of a lipid peptide compound that is composed of at least one compound selected from among compounds represented by formula (1), analogous compounds thereof and pharmaceutically acceptable salts of these compounds; a surfactant; water; 1, 2-alkanediol or 1, 3-alkanediol; a fatty acid; and at least one substance selected from the group consisting of pigments and powders. Also disclosed is the above-described dispersant for pigments or powders. (In the formula, R1 represents an aliphatic group having 9 to 23 carbon atoms; R2 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, which may have a branched chain having 1 or 2 carbon atoms; R3 represents a -(CH2)n-X group; n represents a number of 1 to 4; and X represents an amino group, a guanidino group, a -CONH2 group, or a fused heterocyclic ring that is composed of a five-membered ring and/or a six-membered ring, which may have 1 to 3 nitrogen atoms.).

Description

Dispersion liquid containing dispersant for pigment or powder

The present invention relates to a dispersion liquid containing a dispersant for a pigment or a powder. In particular, the present invention relates to a dispersion liquid containing a dispersant for a pigment or a powder made of a lipid peptide compound and the aforementioned pigment or powder. Body Dispersant.

Water-based compositions have a high cooling sensation when used on the skin, etc. Compared to oil-based compositions, they have no stickiness after use and have a refreshing feel. Therefore, there are various products for cosmetics and other applications. proposal. For example, as a solid-shaped water-based composition, a solid-shaped oil-in-water-type make-up cosmetics (water-based fatty acid soap, oil component, and powder) including makeup (Patent Document 1) and an alkyl group have been proposed in the past. And / or strip-shaped aqueous cosmetics of oligoglycosides, oily substances, and nonionic emulsifiers (Patent Document 2) and the like. In addition, a liquid aqueous composition has conventionally been proposed as a water-based cosmetic containing water as a main component and various additives such as a moisturizing agent, or an emulsifying composition including an emulsifier in an oily component and an aqueous component. Thing. [Prior Art Literature] [Patent Literature]

[Patent Document 1] Japanese Patent Application Laid-Open No. 3-279319 [Patent Document 2] Japanese Patent Application No. 2002-516818

[Problems to be Solved by the Invention]

Although the above-mentioned water-based cosmetics are proposed to be used for coloring the skin, for example, many products such as various pigments or powders are prepared. However, when such water-based cosmetics are left standing for a long period of time, the pigments and powders may separate and settle. A hard cake was produced. Therefore, the review has proposed proposals to stabilize the dispersion by blending various additives such as resins, tackifiers, and dispersants, and it is necessary to further suppress the separation and sedimentation of pigments or powders and their aggregation or curing. Technical proposal.

The present invention has been completed based on the above-mentioned circumstances, and a problem to be solved is to provide a dispersion liquid and a dispersant which can prevent separation and sedimentation of pigments and the like over time in a dispersion liquid containing a pigment or powder. [Means to solve the problem]

As a result of careful research by the present inventors in order to solve the above-mentioned problems, it has been found that a dispersion of a low-molecular-weight lipid peptide or a lipid-peptide compound formed from a pharmaceutically acceptable salt thereof can be used as a dispersant for pigments or powders. In the liquid, a dispersion liquid that suppresses separation and settling of a prepared pigment and the like with time is completed to complete the present invention.

In other words, the first aspect relates to a dispersion including at least one of a surfactant, water, a compound represented by the following formula (1) to formula (3), or a pharmaceutically acceptable salt thereof. Pigment or powder dispersant composed of lipid peptide compounds, 1,2-alkanediol or 1,3-alkanediol, at least one fatty acid, and selected from the group consisting of pigments and powders At least one (In the formula, R ¹ represents an aliphatic group having 9 to 23 carbon atoms, R ² represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms which may have a branched chain of 1 or 2 carbon atoms, and R ³ represents -(CH ₂ ) nX group, n represents a number of 1 to 4, X represents an amine group, guanidino, -CONH ₂ group, or a 5-membered ring or a 6-membered ring which may have 1 to 3 nitrogen atoms or (Condensed heterocycle consisting of 5-membered ring and 6-membered ring) (In the formula, R ⁴ represents an aliphatic group having 9 to 23 carbon atoms, and R ⁵ to R ⁷ each independently represent a hydrogen atom and an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms. Or-(CH ₂ ) nX group, and at least one of R ⁵ to R ⁷ represents a-(CH ₂ ) nX group, n represents a number from 1 to 4, and X represents an amine group, a guanidino group, and -CONH ₂ Or a 5-membered ring or 6-membered ring which may have 1 to 3 nitrogen atoms or a condensed heterocyclic ring composed of a 5-membered ring and a 6-membered ring) (In the formula, R ⁸ represents an aliphatic group having 9 to 23 carbon atoms, and R ⁹ to R ¹² each independently represent a hydrogen atom and an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms. Or-(CH ₂ ) nX group, and at least one of R ⁹ to R ¹² represents a-(CH ₂ ) nX group, n represents a number of 1 to 4, X represents an amine group, a guanidino group, and -CONH ₂ Or a 5-membered ring or 6-membered ring having 1 to 3 nitrogen atoms or a condensed heterocyclic ring composed of a 5-membered ring and a 6-membered ring). A second aspect is the dispersion liquid according to the first aspect, wherein the at least one selected from the group consisting of the pigments and powders described above is based on the total mass of the dispersion liquid and contains a ratio of 25% by mass or less. A third aspect is the dispersion liquid according to the first aspect or the second aspect, wherein the pigment or powder dispersing agent contains a ratio of 0.01% by mass to 1% by mass based on the total mass of the dispersion. The fourth aspect is a dispersion liquid according to any one of the first to third aspects, and further contains a polyhydric alcohol. A fifth aspect is the dispersion liquid according to the fourth aspect, wherein the polyol is glycerin. The sixth aspect is the dispersion liquid according to any one of the first to fifth aspects, wherein the surfactant is selected from the group consisting of a glycol alkyl ether, a phospholipid, a polyglycerol fatty acid ester, and a polyoxyethylene polyoxypropylene. One or more compounds of the group consisting of alkyl ethers. The seventh aspect is the dispersion liquid according to any one of the first to sixth aspects, wherein the fatty acid is stearic acid. The eighth aspect relates to the dispersion liquid according to any one of the first to seventh aspects, and is a dispersion liquid for cosmetics. The ninth aspect relates to a dispersant for pigments or powders, which is a lipid peptide type formed from at least one of a compound represented by the following formula (1) to formula (3) or a pharmaceutically acceptable salt thereof. Made of compounds, (In the formula, R ¹ represents an aliphatic group having 9 to 23 carbon atoms, R ² represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms which may have a branched chain of 1 or 2 carbon atoms, and R ³ represents -(CH ₂ ) nX group, n represents a number of 1 to 4, X represents an amine group, a guanidino group, a -CONH ₂ group, or a 5-membered ring or a 6-membered ring or a 5-membered ring which may have 1 to 3 nitrogen atoms (Condensed heterocyclic ring consisting of 6-membered ring) (In the formula, R ⁴ represents an aliphatic group having 9 to 23 carbon atoms, and R ⁵ to R ⁷ each independently represent a hydrogen atom and an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms. Or-(CH ₂ ) nX group, and at least one of R ⁵ to R ⁷ represents a-(CH ₂ ) nX group, n represents a number from 1 to 4, and X represents an amine group, a guanidino group, and -CONH ₂ Or a 5-membered ring or 6-membered ring which may have 1 to 3 nitrogen atoms or a condensed heterocyclic ring composed of a 5-membered ring and a 6-membered ring) (In the formula, R ⁸ represents an aliphatic group having 9 to 23 carbon atoms, and R ⁹ to R ¹² each independently represent a hydrogen atom and an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms. Or-(CH ₂ ) nX group, and at least one of R ⁹ to R ¹² represents a-(CH ₂ ) nX group, n represents a number of 1 to 4, X represents an amine group, a guanidino group, and -CONH ₂ Or a 5-membered ring or 6-membered ring having 1 to 3 nitrogen atoms or a condensed heterocyclic ring composed of a 5-membered ring and a 6-membered ring). [Inventive effect]

According to the present invention, by using a lipid-peptide compound as a dispersant for a pigment or a powder, the pigment or the powder does not separate or settle from the dispersion liquid with time, and it can be a dispersion liquid for stably dispersing these. . In particular, by using the dispersant of the present invention, a stable dispersed dispersion liquid can be prepared even when a pigment is blended at 10% by mass or more, or when a relatively large powder such as gold foil is blended.

In addition, the lipid peptide compound constituting the dispersant of the present invention is an artificial low-molecular compound having very high safety composed of only lipids and peptides. In addition, in the dispersion liquid of the present invention, various components contained as additives are additives commonly used as additives for foods, cosmetics, and pharmaceuticals. That is, the dispersion liquid of the present invention is highly biosafe, and is particularly useful for the above-mentioned applications from the viewpoint of safety required for pharmaceuticals, cosmetics, and the like. In addition, when the dispersion liquid of the present invention is used on human skin or the like, a dispersion liquid with a cool feeling and good spreadability can be expected, and it can be expected to be used as a liquid base material prepared with pigments or powders for pharmaceutical or cosmetic applications. very useful.

[Form of Implementing Invention]

The present invention relates to a dispersion liquid comprising a lipid formed by at least one of a surfactant, water, a compound represented by the following formula (1) to formula (3) or a pharmaceutically acceptable salt thereof Dispersant for pigment or powder composed of peptide compound, 1,2-alkanediol or 1,3-alkanediol, fatty acid, at least one selected from the group consisting of pigment and powder, and desired Other additives. In addition, the present invention is also directed to a pigment or a dispersant for a powder composed of the aforementioned lipid peptide compound. Each component will be described below.

[Dispersant for pigment or powder: lipid peptide compound] As the lipid peptide compound used for the pigment or powder dispersant of the present invention, a compound (lipid) represented by the following formula (1) to formula (3) can be used Peptide) or a pharmaceutically acceptable salt thereof (a low molecular compound having a lipid portion having a hydrophobic portion and a peptide portion having a hydrophilic portion).

In the above formula (1), R ¹ represents an aliphatic group having 9 to 23 carbon atoms, and preferably R ¹ is a straight-chain aliphatic group having 11 to 23 carbon atoms which may have 0 to 2 unsaturated bonds. Specific examples of the lipid moiety (fluorenyl group) composed of a carbonyl group adjacent to R ¹ include laurylfluorenyl, dodecylcarbonyl, myristyl, tetradecylcarbonyl, palmitoyl, and heptadecyl , Oleyl, oleyl, linoleyl, stearyl, octadecenyl, octadecylcarbonyl, arachidonyl, eicosylcarbonyl, behenyl , Twenty-two alkenyl, behenyl carbonyl, xylofluorenyl, neural fluorenyl, etc. Particularly preferred are lauryl, myristyl, palmitoyl, heptadecyl, Stearyl, oleyl, anti-oleyl and behenyl.

In the above formula (1), R ² included in the peptide portion represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms which may have a branch having 1 or 2 carbon atoms. The above-mentioned alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms means an alkyl group having 1 to 4 carbon atoms in the main chain and may have a branched chain having 1 or 2 carbon atoms Specific examples include methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, sec-butyl, and tert-butyl. The aforementioned R ^{2 is} preferably a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, which may have a branched chain of 1 carbon atom, and more preferably a hydrogen atom. The alkyl group having 1 to 3 carbon atoms which may have a branch having 1 carbon atom means an alkyl group having 1 to 3 carbon atoms in the main chain and may have a branched chain having 1 carbon atom, and specific examples thereof, Examples include methyl, ethyl, n-propyl, i-propyl, i-butyl, or sec-butyl, and methyl, i-propyl, i-butyl, or sec-butyl is preferred.

In the formula (1), R ³ represents a-(CH ₂ ) nX group. In the above- (CH ₂ ) nX group, n represents a number of 1 to 4, and X represents an amine group, a guanidino group, a -CONH ₂ group, or a 5-membered cyclic group or 6-membered group which may have 1 to 3 nitrogen atoms. A cyclic group or a condensed heterocyclic group consisting of a 5-membered ring and a 6-membered ring. In the-(CH ₂ ) nX group representing the above R ³ , X is preferably an amine group, a guanidyl group, an aminoformyl group (-CONH ₂ group), a pyrrolyl group, an imidazolyl group, a pyrazolyl group, or an indolyl group, More preferred is imidazolyl. In the above- (CH ₂ ) nX group, n is preferably 1 or 2, and more preferably 1. Therefore, the-(CH ₂ ) n- group preferably represents aminomethyl, 2-aminoethyl, 3-aminopropyl, 4-aminobutyl, aminomethylmethyl, 2-aminomethylamidinoethyl, 3-aminomethylamidinobutyl, 2-guanidinoethyl, 3-guanidinobutyl, pyrrolylmethyl, 4-imidazolylmethyl, pyrazolylmethyl, or 3-Indolemethyl, more preferably 4-aminobutyl, aminomethylmethyl, 2-aminomethylmethylethyl, 3-guanidinobutyl, 4-imidazolylmethyl or 3 -Indolemethyl, and more preferably 4-imidazolylmethyl.

Among the compounds represented by the above formula (1), as the lipid peptide compound, a particularly preferred lipid peptide is a compound formed of the following lipid portion and peptide portion (amino acid aggregation portion). The abbreviation of amino acid means alanine (Ala), asparagine (Asn), glutamine (Gln), glycine (Gly), and histidine (His). ), Isoleucine (Ile), Leucine (Leu), Lysine (Lys), Tryptophan (Trp), Valine (Val). Laurel-Gly-His, Laurel-Gly-Gln, Laurel-Gly-Asn, Laurel-Gly-Trp, Laurel-Gly-Lys, Laurel-Ala-His, Laurel-Ala-Gln, Laurel醯 -Ala-Asn, Laurel 醯 -Ala-Trp, Laurel A-Ala-Lys; Nutmeg 醯 -Gly-His, Nutmeg 醯 -Gly-Gln, Nutmeg 醯 -Gly-Asn, Nutmeg 醯 -Gly- Trp, Nutmeg-Gly-Lys, Nutmeg-Ala-His, Nutmeg-Ala-Gln, Nutmeg-Ala-Asn, Nutmeg-Ala-Trp, Nutmeg-Ala-Lys; Palm Falcon-Gly-His, Palm Falcon-Gly-Gln, Palm Falcon-Gly-Asn, Palm Falcon-Gly-Trp, Palm Falcon-Gly-Lys, Palm Falcon-Ala-His, Palm Falcon-Ala-Gln, Palm醯 -Ala-Asn, palm 醯 -Ala-Trp, palm 醯 -Ala-Lys; stearyl 醯 -Gly-His, stearyl 醯 -Gly-Gln, stearyl 醯 -Gly-Asn, stearyl 醯 -Gly- Trp, stearylamine-Gly-Lys, stearylamine-Ala-His, stearylamine-Ala-Gln, stearylamine-Ala-Asn, stearylamine-Ala-Trp, stearylamine-Ala-Lys.

The best ones can be listed as Laurel-Gly-His, Laurel-Ala-His-Myristica-Gly-His, Myristica-Ala-His; Palm-Gly-His, Palm-Ala-His; Stearylamine-Gly-His, Stearylamine-Ala-His.

In the formula (2), R ⁴ represents an aliphatic group having 9 to 23 carbon atoms. Preferred specific examples include the same groups as those defined by the aforementioned R ¹ . In the above formula (2), R ⁵ to R ⁷ each independently represent a hydrogen atom, or an alkyl group having 1 to 4 carbon atoms, or a-(CH ₂ ) nX group, which may have a branch of 1 or 2 carbon atoms, In addition, at least one of R ⁵ to R ⁷ represents a-(CH ₂ ) nX group. n represents a number of 1 to 4, and X represents an amine group, a guanidino group, a -CONH ₂ group, or a 5-membered cyclic group or a 6-membered cyclic group which may have 1 to 3 nitrogen atoms, or a 5-membered ring and 6 Condensed heterocyclic group consisting of member rings. Here, preferable specific examples of R ⁵ to R ⁷ include the same bases as those defined by the aforementioned R ² and R ³ .

Among the compounds represented by the formula (2), a preferred lipid peptide is a compound formed from the following lipid portion and peptide portion (amino acid assembly portion). For example, Laurel-Gly-Gly-His, Laurel-Gly-Gly-Gln, Laurel-Gly-Gly-Asn, Laurel-Gly-Gly-Trp, Laurel-Gly-Gly-Lys, Laurel-Gly -Ala-His, Laurel-Gly-Ala-Gln, Laurel-Gly-Ala-Asn, Laurel-Gly-Ala-Trp, Laurel-Gly-Ala-Lys, Laurel-Ala-Gly-His, Laurel-Ala-Gly-Gln, Laurel-Ala-Gly-Asn, Laurel-Ala-Gly-Trp, Laurel-Ala-Gly-Lys, Laurel-Gly-His-Gly, Laurel-His -Gly-Gly, Nutmeg 醯 -Gly-Gly-His, Nutmeg 醯 -Gly-Gly-Gln, Nutmeg 醯 -Gly-Gly-Asn, Nutmeg 醯 -Gly-Gly-Trp, Nutmeg 醯 -Gly -Gly-Lys, Nutmeg 醯 -Gly-Ala-His, Nutmeg --Gly-Ala-Gln, Nutmeg 醯 -Gly-Ala-Asn, Nutmeg 醯 -Gly-Ala-Trp, Nutmeg 醯 -Gly -Ala-Lys, Nutmeg 醯 -Ala-Gly-His, Nutmeg 醯 -Ala-Gly-Gln, Nutmeg 醯 -Ala-Gly-Asn, Nutmeg 醯 -Ala-Gly-Trp, Nutmeg 醯 -Ala -Gly-Lys, Myristyl-Gly-His-Gly, Myristyl-His-Gly-Gly, Palm-Eat-Gly-Gly-His, Palm-Eat-Gly-Gly-Gln, Palm-Eat-Gly-Gly -Asn, Palm Falcon-Gly-Gly-Trp, Palm Falcon-Gly-Gly-Lys, Palm Falcon-Gly-Ala-His, Palm Falcon-Gly-Ala-Gln, Palm Falcon-Gly-Ala-Asn, Palm Falcon-Gly-Ala-Trp, Palm Falcon-Gly-Ala-Lys, Palm Falcon-Ala- Gly-His, Palm Falcon-Ala-Gly-Gln, Palm Falcon-Ala-Gly-Asn, Palm Falcon-Ala-Gly-Trp, Palm Falcon-Ala-Gly-Lys, Palm Falcon-Gly-His-Gly, Palm Hi-His-Gly-Gly, stearin 醯 -Gly-Gly-His, stearin 醯 -Gly-Gly-Gln, stearin 醯 -Gly-Gly-Asn, stearin 醯 -Gly-Gly-Trp, stearin醯 -Gly-Gly-Lys, stearin 醯 -Gly-Ala-His, stearin 醯 -Gly-Ala-Gln, stearin 醯 -Gly-Ala-Asn, stearin 醯 -Gly-Ala-Trp, stearin醯 -Gly-Ala-Lys, stearin 醯 -Ala-Gly-His, stearin 醯 -Ala-Gly-Gln, stearin 醯 -Ala-Gly-Asn, stearin 醯 -Ala-Gly-Trp, stearin -Ala-Gly-Lys, stearyl 醯 -Gly-His-Gly, stearyl 醯 -His-Gly-Gly.

Among these, the best are laurel-Gly-Gly-His, nutmeg-Gly-Gly-His, palm --- Gly-Gly-His, palm --- Gly-His-Gly, palm-- -His-Gly-Gly, stearylamine-Gly-Gly-His.

In the above formula (3), R ⁸ represents an aliphatic group having 9 to 23 carbon atoms. Preferred specific examples include the same groups as those defined by the aforementioned R ¹ . In the above formula (3), each of R ⁹ to R ¹² independently represents a hydrogen atom, or an alkyl group having 1 to 4 carbon atoms, or a-(CH ₂ ) nX group, which may have a branch having 1 or 2 carbon atoms, In addition, at least one of R ⁹ to R ¹² represents a-(CH ₂ ) nX group. n represents a number of 1 to 4, and X represents an amine group, a guanidino group, a -CONH ₂ group, or a 5-membered cyclic group or a 6-membered cyclic group which may have 1 to 3 nitrogen atoms, or a 5-membered ring and 6 Condensed heterocyclic group consisting of member rings. Here, preferable specific examples of R ⁹ to R ¹² include the same bases as those defined by the aforementioned R ² and R ³ .

Therefore, among the compounds represented by the above formula (3), preferred are lipid peptide compounds, and among them, particularly preferred lipid peptides include Laurel-Gly-Gly-Gly-His, Myristium-Gly-Gly-Gly-His, Palm 醯 -Gly-Gly-Gly-His, Palm 醯 -Gly-Gly-His-Gly, Palm 醯 -Gly-His-Gly-Gly, Palm 醯 -His-Gly-Gly-Gly, Stearyl 醯 -Gly- Gly-Gly-His et al.

In the present invention, the blending amount of the lipid peptide compound of the dispersant for pigment or powder is relative to the total mass of the obtained dispersion liquid, for example, 0.01 mass% to 1 mass%, or 0.01 mass% or more and less than 1 mass %, Preferably 0.05% by mass to 0.5% by mass, more preferably 0.05% by mass to 0.3% by mass, such as 0.05% by mass to 0.2% by mass. In addition, the lipid-peptide compound usable in the present invention is composed of at least one of the compound (lipid peptide) represented by the above formula (1) to formula (3) or a pharmaceutically acceptable salt thereof as a pigment Or powder dispersants, these compounds can be used alone or in combination of two or more.

[Surfactant] As the surfactant used in the dispersion of the present invention, a compound having a hydrophilic portion and a hydrophobic portion in the molecule and a betaine structure in the hydrophilic portion (hereinafter also referred to as a betaine-based compound) can be suitably used. ), Glycol alkyl ethers, polyglycerol fatty acid esters, or polyoxyethylene polyoxypropylene alkyl ethers.

As the above-mentioned betaine-based compound, for example, N-alkyl-N, N-dimethylamino acid betaine such as lauryl dimethylaminoacetic acid betaine (lauryl betaine) can be used; coconut oil tincture Fatty acids such as aminopropyl betaine, lauryl aminopropyl betaine, amino alkyl-N, N-dimethylamino betaine; Sodium Cocoamphoacetate, lauryl amphoteric Imidazoline type beets such as sodium acetate; alkyl sulfobetaines such as lauryl hydroxysulfobetaine, alkyl dimethyl taurine; sulfuric acid type beets such as alkyl dimethyl amino ethanol sulfate Bases; phosphate betaines such as alkyl dimethylaminoethanol phosphate; and other amphoteric surfactants are known betaine-based compounds. The betaine-based compounds include, for example, phosphatidylcholine, phosphatidylethanolamine, phospholipid serine, phospholipids inositol, phospholipids glycerol, and diphospholipids glycerol (cardiolipin) , Glycerophospholipids such as phosphatidic acid, lysophospholipid choline (lysolecithin, lysolecithin), lysophospholipid ethanolamine, lysophospholipid serine, lysophospholipid inositol, lysophospholipid glycerol, lysophospholipid, etc. Phospholipids; sphingomyelins such as Sphingomyelin; and hydrides of these. These phospholipids may be those produced by plants such as soybeans, egg yolk, etc., or synthesized by chemical or enzyme methods. Among the above betaine-based compounds, lauryl dimethylaminoacetic acid betaine, amidopropyl betaine laurate, lauryl hydroxysulfobetaine, stearyl betaine, and lysophospholipid choline (hemolytic Lecithin, lysolecithin), lysophospholipid ethanolamine, lysophospholipid serine, phospholipid inositol, lysophospholipid, glycerol, lysophosphatidic acid (LPA), etc., and more preferably lysophospholipid choline (lysocithin) ).

Examples of the ethylene glycol alkyl ether include polyoxyethylene alkyl ether, polyoxyethylene lauryl ether, polyoxyethylene palmitic ether, and polyoxyethylene stearyl ether. Commercial products can also be used as the glycol alkyl ethers. Examples of such products include EMULGEN (registered trademark) series and EMANON (registered trademark) series of Kao Corporation, EMULGEN 102KG, EMULGEN 103, and EMULGEN 104P. EMULGEN 105, EMULGEN 106, EMULGEN 108, EMULGEN 109P, EMULGEN 120, EMULGEN 123P, EMULGEN 130K, EMULGEN 147, EMULGEN 150, EMULGEN 210P, EMULGEN 220, EMULGEN 306P, EMULGEN 320P, EMULGEN 350, EMULGEN 404, EMULGEN 408, EMULGEN 409PV, EMULGEN 420, EMULGEN 430, EMULGEN 705, EMULGEN 707, EMULGEN 709, EMULGEN 1108, EMULGEN 1118S-70, EMULGEN 1135S-70, EMULGEN 1150S-60, EMULGEN 4085, EMULGEN 2020G-HA, EMULGEN 2025G, EMANON 1112, EMANON 3199V, EMANON 3299V, EMANON 3299RV, EMANON 4110. More preferably, EMULGEN 103, EMULGEN 104P, EMULGEN 105, EMULGEN 106, EMULGEN 108, EMULGEN 109P, EMULGEN 210P, EMULGEN 306P, EMULGEN 320P, EMULGEN 404, EMULGEN 408, EMULGEN 409PV, EMULGEN 420, EMULGEN can be listed. 705, EMULGEN 707, EMULGEN 709, EMULGEN 1108, EMULGEN 2020G-HA, EMANON 1112, EMANON 4110. Even more preferred are EMULGEN 104P, EMULGEN 105, EMULGEN 106, EMULGEN 108, EMULGEN 210P, EMULGEN 306P, EMULGEN 408, EMULGEN 409PV, EMULGEN 705, EMULGEN 707, EMULGEN 709, EMULGEN 1108, EMULGEN 2020G- HA, EMANON 1112, EMANON 4110. In addition, it may be appropriately selected from the NIKKOL (registered trademark) series of NIKKO CHEMICALS. Examples include NIKKOL BT-5, NIKKOL BT-7, NIKKOL BT-9, NIKKOL BT-12, NIKKOL BL-2, NIKKOL BL-4.2, NIKKOL BL-9EX, and the like, and most preferably NIKKOL BL-4.2.

Examples of the polyglycerol fatty acid ester include glyceryl stearate, glyceryl isostearate, glycerol palmitate, glyceryl myristate, glyceryl oleate, glycerol coconut fatty acid ester, and glycerol mono-cotton oil fat Esters of glycerol fatty acids, such as glycerol monoerucate, glyceryl sesquioleate, α, α'-glyceryl oleate pyroglutamate, glycerol monostearate malate, etc .; polyglycerin-2 hard Polyglyceryl-2 Stearate, Same as 3, Same as 4, Same with 5, Same with 6, Same with 8, Same with 10, Polyglyceryl-6 distearate, Same with 10, Polyglycerol-2 tristearate , Polyglycerol-10 Decanostearate, Polyglycerol-2 Isostearate, Same 3, Same 4, Same 5, 5, Same 8, Same 10, Polyglycerol-2 Diisostearate ( Diglycerol diisostearate), same as 3, 10 (decaglycerol diisostearate), polyglycerol-2 triisostearate, polyglycerol-2 tetraisostearate, polyglycerin -10 Decaisostearate, Polyglycerol-2 Oleate, Same 3, Same 4, Same 5, Same 6, 8, 8, 10, Polyglycerol-6 Dioleate, Polyglycerol-2 Tri-oil Acid esters, polyglycerol-10 decaoleate, and the like.

Polyoxyethylene polyoxypropylene alkyl ethers include EMULGEN (registered trademark) LS-106, EMULGEN LS-110, EMULGEN LS-114, EMULGEN MS-110, and NIKKOL (registered) of NIKKO CHEMICALS (shares). Trademarks) PBC-31, NIKKOL PBC-33, NIKKOL PBC-34, NIKKOL PBC-41, NIKKOL PBC-44, NIKKOL PBN-4612, NIKKOL PBN-4620, NIKKOL PBN-4630. More preferred examples include EMULGEN LS-106, EMULGEN LS-110, EMULGEN LS-114, and EMULGEN MS-110. More preferred examples include EMULGEN LS-106, EMULGEN LS-110, and EMULGEN MS-110.

The surfactant used in the present invention is preferably one having an HLB (Hydrophile-Lipophile Balance) value of 8 to 20. More preferably, the HLB value is 8 to 14. Examples of such a surfactant include sorbitan isostearate, STEARETH-8, Beheneth-10, LAURETH-4, LAURETH-5, CETETH-7, Oleth-8, and PEG-8 glyceryl isostearic acid. Ester, Choleth-10, PEG-10BG isostearate, PEG-30 glyceryl triisostearate, PEG-30 glyceryl triisostearate, PEG-30 glyceryl trioleate, triisostearate PEG-30 trimethylolpropane, lauric acid PEG-30 hydrogenated castor oil, PCA isostearic acid PEG-30 hydrogenated castor oil, Octyldodeceth-10, lauric acid PEG-12, Sorbeth-40 Tetraoleate, polyglycerol diiso Stearate-10 (decisoglyceryl diisostearate), PEG-20 diisostearate, PEG-8 isostearate, PEG-10 isostearate, triisostearate Acid PEG-60 hydrogenated castor oil, PPG-2-Deceth-7, Oleth-10, Hydrogenated Dimer Dilinoleth-20, coconut fatty acid sorbitan, ISOSTEARETH-10, STEARETH-11, trimyristic acid PEG-30 trihydroxy Methylpropane, PEG-40 isostearic acid hydrogenated castor oil, PEG-40 isostearic acid hydrogenated castor oil, PCA isostearic acid PEG-40 hydrogenated castor oil, LAURETH-7, ISOCETETH-10, Ceteth-10, Isostearic acid P EG-10, PEG-10 stearic acid, PEG-10 oleic acid, PEG-10 glyceryl stearate, Oleth-12, DECYLTETRADECETH-15, Choleth-15, PEG-16 dilaurate, PEG-30 hydrogenated castor Sesame oil, PEG-40 glycerol triisostearate, PEG-40 glycerol trioleate, triisostearate PEG-40 trimethylolpropane, lauric acid PEG-40 hydrogenated castor oil, lauric acid PEG-12 Wait.

In the present invention, the compounding amount of the surfactant is relative to the total mass of the obtained dispersion liquid, for example, 0.01 mass% to 2 mass%, and, for example, 0.01 mass% to 1 mass%, preferably 0.01 mass% It is 0.5 mass%, more preferably 0.01 mass% to 0.3 mass%, for example, 0.02 mass% to 0.2 mass%. In addition, the surfactant that can be used in the present invention is at least one of the above-mentioned surfactant groups, and these surfactants can be used alone or in combination of two or more.

[1,2-alkanediol or 1,3-alkanediol] 的 The 1,2-alkanediol or 1,3-alkanediol used in the dispersion liquid of the present invention is used for promoting the pigment or powder. Solubility of dispersants for lipid-peptide compounds.具体 Specific examples of the 1,2-alkanediol include 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, and 1,2-decanediol. Preferred are 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol. Even more preferred is 1,2-pentanediol or 1,2-hexanediol. Specific examples of the 1,3-alkanediol include 1,3-propanediol, 2-methyl-1,3-propanediol, 1,3-butanediol, and 3-methyl-1,3-butanediol. Alcohol, 1,3-pentanediol, 1,3-hexanediol, 2-ethyl-1,3-hexanediol, 2-ethyl-1,3-octanediol, and 1,3-decane Alcohol and so on. Preferred are 1,3-butanediol, 1,3-pentanediol, 1,3-hexanediol, 2-ethyl-1,3-hexanediol, 2-ethyl-1,3-octane Diol. Even more preferred are 1,3-butanediol, 2-ethyl-1,3-hexanediol, and 2-ethyl-1,3-octanediol.等 These 1,2-alkanediols or 1,3-alkanediols can be used alone or in combination of two or more kinds.

In the present invention, the blending amount of 1,2-alkanediol or 1,3-alkanediol is relative to the total mass of the obtained dispersion liquid, for example, is 0.001% by mass to 15% by mass, and preferably 0.005% by mass. 15 mass%, more preferably 0.01 mass% to 15 mass%, such as 0.01 mass% to 12 mass%.

[Fatty acid] (1) The fatty acid used in the dispersion of the present invention is preferably at least one selected from the group consisting of saturated fatty acids having 10 to 20 carbon atoms, unsaturated fatty acids, and salts of these fatty acids, such as fatty acids Examples include capric acid, undecanoic acid, lauric acid, tridecanoic acid, myristic acid, pentadecanoic acid, palmitic acid, heptadecanoic acid, and stearic acid. Still more preferred are capric acid, lauric acid, myristic acid, palmitic acid, and stearic acid, of which stearic acid is preferred. In the present invention, the blending amount of the fatty acid used is relative to the total mass of the obtained dispersion, for example, 0.001% to 1% by mass, preferably 0.001% to 0.1% by mass, and more preferably 0.005% by mass to 0.05% by mass. In addition, the fatty acid used in the present invention is at least one selected from the aforementioned fatty acid groups, and these fatty acids are used alone or in combination of two or more.

[Pigment or Powder] The pigment or powder to be formulated in the dispersion liquid of the present invention is not particularly limited. Examples of pigments include inorganic white pigments such as titanium dioxide and zinc oxide; inorganic red pigments such as red iron oxide (iron oxide red) and iron titanate; inorganic brown pigments such as γ-iron oxide; inorganic yellow such as iron oxide yellow and loess Pigments; inorganic black pigments such as iron oxide black and low-priced titanium oxide; inorganic violet pigments such as manganese violet and cobalt violet; inorganic green pigments such as chromium oxide, chromium hydroxide, and cobalt titanate; ultramarine and Prussian blue Inorganic blue pigments; pearlescent pigments such as titanium oxide coated mica, titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, fish scale foil; talc, sericite , mica, Constitution pigments of kaolin, calcium carbonate, magnesium carbonate, anhydrous silicic acid, barium sulfate, aluminum hydroxide, etc .; metal powder pigments such as aluminum powder, copper powder, gold, etc .; surface treatment inorganic and metal powder pigments; zirconium, barium or aluminum color Organic pigments such as lakes; surface-treated organic pigments. Among these pigments, hydrophilic pigments are more preferred. Examples of the powder include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, red mica, biotite, vermiculite, magnesium carbonate, calcium carbonate, and silicic acid. Aluminum, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, tricalcium phosphate, etc. Limestone, ceramic powder, bentonite, smectite, clay, mud, metal soap (e.g. zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, iron oxide red, iron oxide yellow, iron oxide black , Ultramarine, Prussian blue, carbon black, titanium oxide, fine particles and ultrafine particles of titanium oxide, zinc oxide, fine particles and ultrafine particles of zinc oxide, aluminum oxide, silicon dioxide, fumes of silicon dioxide (ultrafine anhydrous silicic acid), titanium mica , Fish scale foil, boron nitride, photochromic pigment, synthetic fluorophlogopite, fine particle composite powder, gold, silver, platinum, aluminum and other inorganic powders of various sizes / shapes, and use these powders with hydrosiloxane , Cyclohydrosiloxane, etc. Various surface treatment agents such as alkane or titanium coupling agent are processed to form inorganic powders such as hydrophobized or hydrophilized powders; starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene Powder, styrene and acrylic copolymer resin powder, polyester powder, benzoguanamine resin powder, polyethylene terephthalate / polymethyl methacrylate laminated powder, polyethylene terephthalate / aluminum / Epoxy compound laminated powder, polyurethane powder, siloxane powder, Teflon (registered trademark) powder and other organic powders and surface treatment powders and organic-inorganic composite powders of various sizes and shapes are preferred. By. In the present invention, the total mass of the pigment or powder system relative to the dispersion may be, for example, 25% by mass or less, and preferably 20% by mass or less. The lower limit of the blending amount of the pigment or powder is not particularly limited, but is, for example, about 0.001% by mass. The pigment or powder system that can be used in the present invention is at least one of the above-mentioned pigment group and powder group, and these pigments or powders can be used alone or in combination of two or more kinds.

[Polyol] The dispersion liquid of the present invention may further contain a polyol. The polyhydric alcohol is a polyhydric alcohol different from the 1,2-alkanediol or 1,3-alkanediol listed above, and specific examples thereof include glycerin, propylene glycol, and polyethylene glycol. The polyethylene glycol may be suitably used, for example, an average molecular weight of 1,000 to 4,000. In the present invention, when a polyhydric alcohol is included, the blending amount may be 1 to 60% by mass, and preferably 10 to 30% by mass relative to the total mass of the obtained dispersion.

[Other additives] 分散 In the dispersion of the present invention, additives which can be generally used as additives for cosmetics, additives for external products of the medical department, and additives for pharmaceuticals can be blended when necessary. Examples of the additional ingredients such as physiologically active substances and functional substances formulated for external skin preparations such as cosmetics, quasi-drugs, or pharmaceuticals include oily bases, moisturizers, touch-up agents, and surfactants other than the above. , Polymer, thickening gelling agent, solvent, antioxidant, reducing agent, oxidant, preservative, antibacterial agent, bactericide, chelating agent, pH adjuster, acid, alkali, inorganic salt, ultraviolet absorber, whitening agent Agents, vitamins and their derivatives, hair growth agents, blood circulation promoters, stimulants, hormones, anti-wrinkle agents, anti-aging agents, tightening agents, cold-sensing agents, warming agents, wound healing Accelerators, stimulants, analgesics, cell activators, plant / animal / biological extracts, antipruritic agents, keratin peels / lytic agents, antiperspirants, cooling agents, astringents, enzymes, nucleic acids, perfumes, pigments, Colorants, dyes, anti-inflammatory agents, anti-inflammatory drugs, anti-asthma, anti-chronic obstructive pulmonary disease agents, anti-allergic agents, immunomodulators, anti-infective agents and anti-inflammatory drugs Agents and so on.调 The blending amount of these other additives may vary depending on the type, but may be about 0.001% to 20% by mass, or about 0.01% to 10% by mass, relative to the total mass of the dispersion.

Examples of the oily base include oleyl alcohol, jojoba alcohol, chimyl alcohol, squalol, sharkol, hexyldecanol, isostearyl alcohol, 2-octyl lauryl alcohol, and dimer dimer. Higher (poly) alcohols such as alcohols; aralkyl alcohols and derivatives thereof such as benzyl alcohol; isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, palmitoleic acid, oil Acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexadecanoic acid, anteisocosanoic acid, long chain branched fatty acids, dimer acids (dimer acid), hydrogenated dimer acid, etc .; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α-olefin oligomer, polyisobutylene, hydrogenated polyisobutylene, polybutene, Squalane, squalane derived from olive, squalene, vaseline, solid paraffin and other hydrocarbons; candelilla wax, carnauba wax, rice wax, wood wax, beeswax, montan wax, ceresin, pure ground Wax, paraffin, microcrystalline wax, paraffin oil, FISCHER-TROPSCH wax, polyethylene wax, ethylene / propylene copolymer and other waxes; coconut oil, palm oil, palm kernel oil , Safflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut nut oil, stone chestnut nut oil, rosehip oil, spiraea oil, peach kernel oil , Tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, cocoa butter, shea butter, hydrogenated coconut oil, hydrogenated castor oil, Vegetable oils such as jojoba oil, hydrogenated jojoba oil, grape seed oil, almond oil (apricot oil), pile oil, etc .; animal fats such as tallow, milk fat, horse fat, egg butter, mink oil, sea turtle oil, etc. ; Animal waxes such as whale wax, lanolin, orange roughy oil; liquid lanolin, reduced lanolin, adsorption and purification of lanolin, lanolin acetate, lanolin acetate liquid, hydroxylanolin, polyoxyethylene wool Fats, lanolin fatty acids, hard lanolin fatty acids, lanolin alcohols, lanolin alcohols, lanolin acetates, lanolin acetates (cetyl / lanolin) acetates; cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol , Sterols such as phytosterol, cholic acid; saponin; saponin; cholesterol acetate, cholesterol nonanoate, cholesterol stearate, cholesterol isostearate, cholesterol oleate, N-laurate -L-glutamate di (cholesterol / docosyl / octyldodecyl) ester, N-lauryl-L-glutamate di (cholesterol / octyldodecyl) ester, N -Lauryl-L-glutamate di (phytosterol / docosyl / octyldodecyl) ester, N-lauryl-L-glutamate di (phytosterol / octyldodecyl) Alkyl alkyl esters such as alkyl) esters, N-lauroyl sarcosinate isopropyl, 12-hydroxystearate cholesterol, macadamia oil fatty acid cholesterol esters, macadamia oil fatty acid plant sterols, isopropyl Stearic acid phytosterols, soft lanolin fatty acid cholesterol esters, hard lanolin fatty acid cholesterol esters, long chain branched fatty acid cholesterol esters, long chain α-hydroxy fatty acid cholesterol esters, and other sterol esters; phospholipid / cholesterol complexes, phospholipids / Lipid complexes such as plant sterol complexes; octyldodecyl myristate, hexyl decyl myristate, isostearyl Octyldodecyl, cetyl palmitate, octyldodecyl palmitate, cetyl octanoate, hexyl decyl octoate, isotridecyl isononanoate, isononyl isononanoate, octanoic isononanoate Esters, isodosanyl isononanoate, isodecanyl pivalate, isodedecyl pivalate, isostearyl pivalate, octyldodecyl neodecanoate, oleyl oleate , Octyldodecyl oleate, ricinoleic acid octyldodecyl ester, lanolin fatty acid octyldodecyl ester, dimethylhexyldecanoate octanoate, octyldodecyl erucate, isopropyl Stearic acid hardened castor oil, ethyl oleate, avocado fatty acid ethyl ester, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl stearate, lanolin fatty acid isopropyl ester , Diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyloctyl sebacate, diisobutyl adipate, succinic acid Monooctyl carboxylic acid esters such as dioctyl ester, triethyl citrate; cetyl lactate, diisostearyl malate, hydrogenated castor oil such as monoisostearic acid; trioctanoic acid Oil esters (triethyl 2-ethylhexanoate), glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, triglyceride (caprylic / capric), tris (caprylic / Capric acid / myristic acid / stearic acid) glyceride, hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), behenyl behenate diglyceride, trioctyl tricaprylate Methylolpropane, trimethylolpropane triisostearate, neopentyl glycol dicaprylate, neopentyl glycol didecanoate, 2-butyl-2-ethyl-1,3-propanediol dicaprylate Esters, propylene glycol dioleate, pentaerythritol tetraoctanoate, pentaerythritol ester of hydrogenated rosin, ditrimethylolpropane triethylhexanoate, (isostearic acid / sebacic acid) ditrimethylolpropane, triethyl Pentaerythritol hexanoate, (hydroxystearic acid / stearic acid / rosin acid) dipentaerythritol ester, diglyceryl diisostearate, polyglycerol tetraisostearate, polyglycerol-10 nonisostearate , Polyglycerol-8 deca (erucic acid / isostearic acid / ricinoleic acid) ester, diglycerol (hexyldecanoic acid / sebacic acid) oligoester, glycolic distearate (ethylene glycol distearate) Alcohol ester), 3-pivalic acid Polyol fatty acid esters such as -1,5-pentanediol, 2,4-diethyl-1,5-pentanediol; dimer diisopropyl linoleate, dimer Diisostearyl linoleate, bis (isostearyl / phytosterol) dilinoleate, dimer bis-linoleate (phytosterol / docosalyl), dimer Linolenic acid (phytosterol / isostearyl / cetyl / stearyl / docosalyl) ester, dimer dilinolenic acid dimer linoleyl alcohol ester, diisostearate di Derivatives of dimer linoleyl alcohol, dimer linoleyl alcohol hydrogenated rosin condensate, dimer linolenic acid hardened castor oil, hydroxyalkyl dimer linoleyl alcohol ether or dimer diol ; Coconut oil fatty acid monoethanolamine (cocoamine melamine), coconut oil fatty acid diethanolamine (cocoamine DEA), lauric acid monoethanolamine (lauramine MEA), laurate diethanolamine (Lauramine DEA), lauric acid monoisopropanolamine (lauramine amine MIPA), palmitic acid monoethanolamine (palmitamine MEA), palmitic acid diethanolamine (palmitamine DEA), coconut oil Fatty acid methylethanolamine (Coco-methylamine MEA) and other fatty acid alkanolamines; dimethyl polysiloxane (dimethyl polysiloxane), high polymer dimethyl polysiloxane (high polymer dimethyl polysiloxane) Alkane), cyclic polydimethylsiloxane (cyclic dimethylsiloxane, decamethylcyclopentylsiloxane (also known as cyclopentylsiloxane)), phenylmethyl polytrimethylsiloxane Siloxane, diphenyldimethylpolysiloxane, phenyldimethylsiloxane, stearyloxypropyldimethylamine, (aminoethylaminopropylpolymethylpolysiloxane / Dimethylpolysiloxane) copolymer, polydimethylsiloxane, polydimethylsiloxane polymer, silicone resin, silicone rubber, aminopropyldimethylsiloxane Polyether-modified silicones, polyglycerols, such as amine-modified silicones, cation-modified silicones, dimethylpolysiloxanes, and diols Modified silicone, sugar modified silicone, carboxylic acid modified silicone, phosphoric acid modified silicone, sulfuric acid modified silicone, alkyl modified silicone, fatty acid modified silicone, alkyl ether modified silicone, Amino acid modified silicone, peptide modified silicone, fluorine modified silicone, cation And polyether-modified silicones, amine-modified and polyether-modified silicones, alkyl-modified and polyether-modified silicones, polysiloxane / alkylene oxide copolymers, and other silicones; perfluorinated Fluorine oils such as decane, perfluorooctane, and perfluoropolyether are preferred.

Examples of the humectant / touch improver include glycerin, trimethylolpropane, pentaerythritol, hexanediol, diglycerin, polyglycerin, diethylene glycol, dipropylene glycol, polypropylene glycol, and ethylene glycol. Polyols such as propylene glycol copolymers and their polymers; glycols such as diethylene glycol monoethyl ether (ethoxy diethylene glycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, and diethylene glycol dibutyl ether Alkyl ethers; water-soluble esters such as polyglyceryl-10 (eicosanedioic acid / tetradecanedioic acid) esters, polyglyceryl-10 tetradecanedioic acid esters; sorbitol, xylitol, erythritol Sugar alcohols such as alcohol, mannitol, and maltitol; glucose, fructose, galactose, mannose, sucrose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, cotton Dextrose, gluconic acid, glucuronic acid, cyclodextrin (α-, β-, γ-cyclodextrin and modified cyclodextrin, such as maltosylation, hydroxyalkylation), β-glucan, crustacean , Chitosan, heparin and derivatives, pectin, arabinogalactan, dextrin, dextran, glycogen, ethyl glucoside, glucosyl ethyl methacrylate polymer or copolymer, etc. Carbohydrates and their derivatives; Hyaluronic acid, sodium hyaluronate; Chondroitin sodium sulfate; Mucin sulfate, caronin sulfate, cutin sulfate, sulfuric acid Skin pigment; Tremella fuciformis extract, Tremella polysaccharide; Fucoidan; Tuberose polysaccharide or polysaccharide of natural origin; Organic acids such as citric acid, tartaric acid, lactic acid and their salts; Urea and its derivatives; 2-Pyrrolidone-5-carboxylic acid And its sodium salts; betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, propylamine Acid, phenylalanine, tyrosine, β-alanine, threonine, glutamic acid, glutamine, aspartic acid, aspartic acid, cystine, cystine, methionine Amino acids, leucine, isoleucine, valine, tryptophan, histidine, taurine and other amino acids and their salts; collagen, fish-derived collagen, steatosis collagen, gelatin, Elastin, collagen-decomposing peptide, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin-decomposing peptide, keratin-decomposing peptide, hydrolysing keratin, shell matrix decomposing peptide, hydrolyzing shell matrix, silk proteolytic peptide, Hydrolyzed Silk, Sodium Lauryl Hydrolyzed Silk, Soy Protein Decomposing Peptide, Wheat Protein Peptide peptides, hydrolyzed wheat proteins, casein-degrading peptides, amidine peptides and other protein peptides and their derivatives; palmitoyl oligopeptides, palmitoyl pentapeptides, palmitoyl tetrapeptides and other amidated peptides; Silylated peptides; lactic acid bacteria culture solution, yeast extract, eggshell membrane protein, submandibular mucin, hypotaurine, sesame lignan glycosides, glutathione, amaranth, whey; chlorine Choline, Phosphocholine; Placenta extract, Elastin, Collagen, Aloe extract, Witch hazel water, Loofah water, Chamomile extract, Licorice extract, Daisy extract, Silk extract, Ironwood extract Animal, plant extracts such as sassafras extract, eucalyptus extract, osmanthus sibirica extract, natural suramin (types 1, 2, 3, 4, 5, 6), hydroxysuramin, suspected suramin, Neuraminamines such as sphingomyelin, ceramide, and glycoceramide containing extracts are preferred.

As the surfactant, preferably, an anionic surfactant, a nonionic surfactant, a cationic surfactant, an amphoteric surfactant, a polymer surfactant, and the like can be mentioned. Preferred examples of the surfactant include anionic surfactants, such as fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfates such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate. Salt; polyoxyethylene alkyl sulfates such as sodium lauryl polyether sulfate, triethanolamine lauryl alcohol polyether sulfate; sodium coco-methyl taurate, potassium coco-methyl taurate, lauryl methyl Sodium taurine, sodium myristyl methyl taurine, sodium lauryl methionate, sodium lauryl sarcosinate, lauryl sarcosinate triethanolamine, lauryl glutamate methyl N-methyl N-methyl amino acid salts such as sodium propyl alanine; sodium coco glutamate, coco glutamine triethanolamine, sodium lauryl glutamate, sodium myristyl glutamate , Sodium stearyl glutamate, palmitoyl aspartate ditriethanolamine, coco propyl alanine triethanolamine, and the like; and polyoxyethylene alkyl ether acetates such as sodium lauryl acetate Salt; succinate salts of sodium lauryl monoethanolamine sodium succinate; fatty acid alkanolamine Carboxylic acid salts; fluorenyl lactate; polyoxyethylene fatty amine sulfate; fatty acid alkanol amine sulfate; fatty acid glyceride sulfate of hardened coconut oil fatty acid sodium sulfate; alkylbenzene polyoxyethylene sulfate; α -Olefin sulfonates such as sodium alkene sulfonate; alkyl sulfosuccinates such as sodium lauryl sulfosuccinate, sodium dioctyl sulfosuccinate; sodium lauryl polyether sulfosuccinate 2 Alkyl ether sulfosuccinates, such as fluorenyl monoethanol ammonium polyoxyethylene sodium sulfosuccinate, sodium lauryl polypropylene glycol sodium sulfosuccinate; sodium tetradecylbenzenesulfonate, tetradecylbenzenesulfonic acid Alkylbenzene sulfonates such as triethanolamine; alkylnaphthalene sulfonates; alkane sulfonates; α-sulfo fatty acid methyl ester salts; fluorenyl isethionates; alkyl glycidyl ether sulfonates ; Alkyl sulfoacetate; Sodium lauryl polyether phosphate, sodium dilauryl polyether phosphate, sodium trilauryl polyether phosphate, sodium monooctadecyl polyether phosphate, and other alkyl ether phosphate salts; lauryl Alkyl phosphate salts such as potassium phosphate; sodium caseinate; alkylaryl ether phosphates; fatty acid amido ether phosphates; Lipids such as lipoglycerin, phospholipids, inositol, and phosphatidic acid; silicone-based anionic surfactants such as carboxylic acid-modified silicones, phosphate-modified silicones, and sulfuric acid-modified silicones; etc .; as nonionic interfaces Examples of the active agent include lauryl alcohol polyether (polyoxyethylene lauryl ether), cetyl alcohol polyether (polyoxyethylene cetyl ether), stearyl alcohol polyether (polyoxyethylene stearyl ether), and mandrill. Alcohol polyether (polyoxyethylene behenyl ether), isostearyl alcohol polyether (polyoxyethylene isostearyl ether), octanol lauryl alcohol (polyoxyethylene octyldodecyl ether) Polyoxyethylene alkyl ethers of various polyoxyethylene addition numbers; polyoxyethylene alkyl phenyl ethers; polyoxyethylene hardened castor oil, polyoxyethylene castor oil, polyoxyethylene hardened castor oil monoisostearate, Polyoxyethylene hardened castor oil triisostearate, polyoxyethylene hardened castor oil monopyroglutamic acid monoisostearate diester, polyoxyethylene hardened castor oil maleic acid and other castor oil and hardened castor oil derivatives Products; polyoxyethylene phytosterols; polyoxyethylene cholesterol; polyoxyethylene cholestanol (Cholestanol); polyoxyethylene lanolin Polyoxyethylene reduced lanolin; polyoxyethylene. Polyoxypropylene cetyl ether, polyoxyethylene. Polyoxypropylene 2-decyl tetradecyl ether, polyoxyethylene. Polyoxypropylene monobutyl ether, polyoxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene. Polyoxyethylene glyceryl ether and other polyoxyethylene. Polyoxypropylene alkyl ethers; polyoxyethylene / polyoxypropylene glycol; (poly) glycerol polyoxypropylene glycol such as PPG-9 diglyceride; glyceryl stearate, glyceryl isostearate, glyceryl palmitate , Glyceryl myristate, Glyceryl oleate, Glycerol fatty acid in coconut oil, Glycerol fatty acid in single cottonseed oil, Glyceryl monoerucate, Glyceryl sesquioleate, Glyceryl α, α-oleate pyroglutamate Partial esters of glycerin fatty acids such as glycerol monostearate and malic acid; polyglycerol-2 stearate, polyglycerol-3 stearate, polyglycerol-4 stearate, polyglycerol-5 stearate , Polyglycerol-6 stearate, polyglycerol-8 stearate, polyglycerol-10 stearate, polyglycerol-6 distearate, polyglycerol-10 distearate, polyglycerol -2 tristearate, polyglycerol-10 decastearate, polyglycerol-2 isostearate, polyglycerol-3 isostearate, polyglycerol-4 isostearate, polyglycerol -5 isostearate, polyglycerol-6 isostearate, polyglycerol-8 isostearate, polyglycerol-10 isostearate, polyglycerol-2 diisostearate (two Diglyceryl isostearate), polyglycerol-3 Isostearate, polyglycerol-10 diisostearate, polyglycerol-2 triisostearate, polyglycerol-2 tetraisostearate, polyglycerol-10 deisostearate, Polyglycerol-2 oleate, polyglycerol-3 oleate, polyglycerol-4 oleate, polyglycerol-5 oleate, polyglycerol-6 oleate, polyglycerol-8 oleate, polyglycerol Polyglycerol fatty acid esters such as -10 oleate, polyglycerol-6 dioleate, polyglycerol-2 trioleate, and polyglycerol-10 decaoleate; ethylene glycol such as ethylene glycol monostearate Mono-fatty acid esters; propylene glycol mono-fatty acid esters such as propylene glycol monostearate; pentaerythritol partial fatty acid esters; sorbitol partial fatty acid esters; maltitol partial fatty acid esters; maltitol ethers; sorbitan monooleate, Sorbitan monoisostearate, Sorbitan monolaurate, Sorbitan monopalmitate, Sorbitan monostearate, Sorbitan sesquioleate, Sorbitan trioleate Esters, sorbitan fatty acid esters such as penta-2-ethylhexyl diglyceride sorbitan, tetra-2-ethylhexyl diglyceride sorbitan; sucrose fatty acid ester, methyl glucoside fat Esters, partial esters of sugar derivatives such as undecylenic acid trehalose; alkyl glucosides such as octyl glucoside; alkyl polyglycosides; lanolin alcohol; reduced lanolin; polyoxyethylene distearate, polyethylene glycol Polyoxyethylene fatty acid mono- and diesters such as alcohol diisostearate, polyoxyethylene monooleate, polyoxyethylene dioleate; polyoxyethylene. Propylene glycol fatty acid esters; polyoxyethylene glycerol fats such as polyoxyethylene glycerol monostearate, polyoxyethylene glycerol monoisostearate, polyoxyethylene glycerol triisostearate, etc. Esters; polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan tetraoleate, and other polyoxylates Ethylene sorbitan fatty acid esters; polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol pentaoleate, polyoxyethylene sorbitol monostearate Esters such as polyoxyethylene sorbitol fatty acid esters; polyoxyethylene methyl glucoside fatty acid esters; polyoxyethylene alkyl ether fatty acid esters; polyoxyethylene animal and vegetable oils and fats such as polyoxyethylene sorbitol beeswax; iso Alkyl glyceryl ethers such as stearyl glyceryl ether, saponin, sharkol, and sharkol; polyhydric alcohol alkyl ethers; polyoxyethylene alkylamines; tetrapolyoxyethylene. Tetrapolyoxypropylene-ethylenediamine condensates; natural surfactants such as saponins and sophorolipids; polyoxyethylene fatty acid ammonium; coconut oil fatty acid monoethanolamine (cocoamine AMEA), coconut oil fatty acid diamine Ethanolamine (cocoamine DEA), monoethanolamine laurate (MEA), diethanolamine laurate (DEA), monoisopropanolamine laurate (MIPA ), Fatty acid alkanols such as palmitic acid monoethanolamine (palmitamine MEA), palmitic acid diethanolamine (palmitamine DEA), coconut oil fatty acid methylethanolamine (cocomethylamine MEA), and the like Amines; alkyldimethylamine oxides such as laurylamine oxide, cocoamine oxide, stearylamine oxide, behenylamine oxide; alkylethoxydimethylamine oxide; polyoxygen Ethylene alkyl mercaptan; polyether-modified silicone such as dimethyl polysiloxane and polysiloxane. Silicone-based nonionic surfactants such as alkylene oxide copolymers, polyglycerol-modified silicones, and sugar-modified silicones; as cationic surfactants, behenyltrimethylammonium chloride, hard Alkyltrimethylammonium chloride such as fatty trimethylammonium chloride, CETRIMONIUM CHLORIDE, lauryltrimethylammonium chloride; stearyltrimethyl bromide Alkyl trimethyl ammonium bromide, such as ammonium; distearyl dimethyl ammonium chloride, dicopalyl dimethyl ammonium chloride, and other dialkyl dimethyl ammonium chlorides; stearylamine propyldiamine Fatty acid amines such as methylamine, stearylamine ethyldiethylamine, and their salts; alkyl etheramines such as stearyloxypropyldimethylamine, and their salts or quaternary salts; ethyl sulfate long chain branch Fatty acid (12 ~ 31) aminopropyl ethyl dimethyl ammonium, ethyl sulfate lanolin fatty acid amino propyl ethyl dimethyl ammonium, and other fatty acid ammonium type quaternary ammonium salts; polyoxyethylene alkylamine And its salts or quaternary salts; alkylamine salts; fatty acid amidoguanidine salts; alkyl ether ammonium salts; alkyltrialkylene glycol ammonium salts; benzalkonium chloride (Benzalkonium Chloride); phenethylammonium salts; chlorine Turn into Pyridinium salts such as cetylpyridinium salts; imidazolium salts; alkyl isoquinoline salts; dialkylmorpholine salts; polyamine fatty acid derivatives; aminopropyldimethylsiloxanes and amines Amino-modified silicones such as terminal dimethyl polysiloxane, cationic modified silicones, cationic modified and polyether-modified silicones, amine-modified and polyether-modified silicones, and other cationic silicones Surfactants and the like; Examples of the amphoteric surfactants include N-alkyl-N, N-dimethylamino betaine such as lauryl betaine (lauryl dimethylaminoacetic acid betaine); coconut oil Fatty acids such as amidopropyl betaine, lauryl amidopropyl betaine, amido alkyl-N, N-dimethylamino betaine; imidazoles, such as sodium coco amphoteric amphoteric acid, and sodium lauryl amphoteric amphoteric acetate Porphyrin-type sugar beet; alkyl dimethyl taurate and other alkyl benzyl beets; alkyl dimethyl amino ethanol sulfate and other sulfate-type betaines; alkyl dimethyl amino ethanol phosphate and other phosphate types Betaine; sphingomyelin such as phospholipids choline, phospholipids ethanolamine, phospholipids serine, sphingomyelin, sphingomyelin, lysolecithin, hydrogenated soybeans Lipids, partially hydrogenated soybean phospholipids, hydrogenated egg yolk phospholipids, partially hydrogenated egg yolk phospholipids, lecithin hydroxide, and other phospholipids; silicone-based amphoteric surfactants; etc .; as polymer surfactants, polyvinyl alcohol, sodium alginate, Starch derivatives, tragacanth, acrylic acid. Methacrylic acid alkyl copolymer; silicone-based various surfactants are preferred.

Examples of the polymer / thickener / gelling agent include guar gum, locust bean gum, cypress seed, carrageenan, galactan, acacia gum, tara gum, tamarind, red algae gum, Echinacea gum, wood hibiscus, agarwood gum, tragacanth, pectin, pectinic acid and sodium salt, salt such as alginic acid and sodium salt, mannan; starch of rice, corn, potato, wheat, etc. Gum, dextran, succinic dextran, curdlan, hyaluronic acid and its salts, xanthan gum, amylopectin, gellan gum, chitin, chitosan, agar, brown algae extract, chondroitin sulfate , Casein, collagen, gelatin, paeony; methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, carboxymethyl cellulose and its sodium And other salts, methyl hydroxypropyl cellulose, cellulose sodium sulfate, dialkyl dimethyl ammonium sulfate cellulose, crystalline cellulose, cellulose powder and other cellulose and its derivatives; soluble starch, carboxymethyl starch, Starch polymers such as methyl hydroxypropyl starch and methyl starch Starch derivatives such as ammonium chloride starch, octenyl succinic corn starch, aluminum; alginic acid derivatives such as sodium alginate, propylene glycol alginate; polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), vinyl Pyrrolidone. Vinyl alcohol copolymer, polyvinyl methyl ether; polyethylene glycol, polypropylene glycol, polyoxyethylene. Polyoxypropylene copolymer; (methacrylic acid oxyethyl carboxybetaine / alkyl methacrylate) copolymer, (acrylate / stearyl acrylate / ethylamine oxide methacrylate) copolymer, etc. Amphoteric methacrylate copolymer; (dimethyl polysiloxane / vinyl dimethyl polysiloxane) crosslinked polymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / Diacetone acrylamide) copolymer AMP; polyvinyl acetate partially saponified, maleic acid copolymer; vinyl pyrrolidone. Dialkylamino alkyl methacrylate copolymer; acrylic resin alkanolamine; polyester, water-dispersible polyester; polyacrylamide; polyacrylate copolymers such as polyethyl acrylate, and carboxyvinyl polymerization Materials, polyacrylic acid and its sodium salts, acrylic acid. Methacrylate copolymer; acrylic acid. Copolymers of alkyl methacrylate; cationized cellulose such as polyquaternium-10, diallyldimethylammonium chloride such as polyquaternium-7. Acrylic acid copolymer, polyquaternary ammonium salt-22 and other acrylic acid. Acrylic acid such as diallyl dimethyl ammonium chloride copolymer, polyquaternium-39. Diallyl dimethyl ammonium chloride. Acrylamide copolymer, acrylic acid. Cationized methacrylate copolymer, acrylic acid. Cationic ammonium methacrylate copolymer, polyquaternary ammonium salt-47 and other acrylic acid. Methyl acrylate. Methacrylamide propyltrimethylammonium chloride copolymer, choline methacrylate polymer; cationized oligosaccharides, cationized dextran, guar hydroxypropyltrimethylammonium chloride and other cations Polysaccharides; polyethyleneimines; cationic polymers; polymers of 2-methacrylic acid oxyethylphosphonium choline such as polyquaternium-51 and copolymers such as butyl methacrylate copolymer; acrylic acid Resin emulsion, polyethylene acrylate emulsion, polyalkyl acrylate emulsion, polyvinyl acetate resin emulsion, natural rubber latex, synthetic latex and other polymer emulsions; nitrocellulose; polyurethanes and various copolymers; various silicones Various; silicone-based copolymers such as acrylic-silicone graft copolymers; various fluorine-based polymers; 12-hydroxystearic acid and its salts; palmitic dextrin, myristic acid dextrin and other dextrin fatty acids Esters; silicic anhydride, fumed silica (ultrafine particle silicic anhydride), magnesium aluminum silicate, sodium magnesium silicate, metal soaps, metal dialkyl phosphates, bentonite, hectorite, organic modified clay minerals, Sucrose fatty acid ester, fructooligosaccharide Fatty acid esters are preferred. Among the foregoing examples, cellulose and its derivatives, alginic acid and its salts, polyvinyl alcohol, hyaluronic acid and its salts, or collagen are preferred.

Examples of the solvent include lower alcohols such as ethanol, 2-propanol (isopropanol), butanol, and isobutanol; ethylene glycols such as propylene glycol, diethylene glycol, dipropylene glycol, and isopentyl glycol; two Ethylene glycol monoethyl ether (ethoxy diethylene glycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, Glycol ethers such as propylene glycol monoethyl ether and dipropylene glycol monoethyl ether; ethylene glycol monoethyl ether acetate, diethylene glycol monoethyl ether acetate, propylene glycol monoethyl ether acetate and the like; amber Glycol esters such as diethoxyethyl acetate, ethylene glycol disuccinate; benzyl alcohol, benzyloxy ethanol, propylene carbonate, dialkyl carbonate, acetone, ethyl acetate, N-methylpyrrolidone ; Toluene and the like are preferred.

Examples of the antioxidant include tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and / or derivatives thereof Substances; erythorbic acid and its derivatives; sulfites such as sodium sulfite; hydrogen sulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulphite; thiotaurine, Hypotaurine; thioglycerol, thiourea, thioglycolic acid, and cysteine hydrochloride are preferred.

Preferred examples of the reducing agent include thioglycolic acid, cysteine, and cysteamine.

Preferred examples of the oxidizing agent include hydrogen peroxide water, ammonium persulfate, sodium bromate, and percarbonic acid.

Examples of the preservative / antibacterial agent / fungicide include hydroxybenzoic acid such as methyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate, and butyl parahydroxybenzoate, and salts or esters thereof; Salicylic acid; sodium benzoate; phenoxyethanol; methylchloroisothiazolinone, methylisothiazolinone and other isothiazolinone derivatives; imidazolin urea; dehydroacetic acid and its salts; phenols; three Halogenated bisphenols, acid amines, quaternary ammonium salts such as triclosan; triclosan, zinc pyrithione, benzalkonium chloride, benzyl ammonium chloride, sorbic acid, chlorhexidine (Chlorhexidine) ), Chlorhexidine gluconate, halocarban, hexachlorophenol, linalool; phenol, isopropylphenol, cresol, thymol, p-chlorophenol, phenylphenol, sodium phenylphenol and other phenols ; Phenyl alcohol, photosensitizers, antibacterial zeolites, and silver ions are preferred.

Examples of the chelating agent include ethylene glycolate (ethylenediaminetetraacetate) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediamine triacetate such as HEDTA3Na; and pentanoate (diethylenetriamine) Pentaacetate); Phytic acid; Phosphonic acids such as glycolic acid and their sodium salts; Polyamino acids such as polyaspartic acid and polyglutamic acid; Sodium polyphosphate, sodium metaphosphate, phosphoric acid ; Sodium citrate, citric acid, alanine, dihydroxyethylglycine, gluconic acid, ascorbic acid, succinic acid, and tartaric acid are preferred.

Examples of the pH adjusting agent / acid / base include ascorbic acid, citric acid, sodium citrate, lactic acid, sodium lactate, potassium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, and hydrochloric acid. , Sulfuric acid, monoethanolamine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl- 1,3-propanediol, arginine, sodium hydroxide, potassium hydroxide, amine water, guanidine carbonate, and ammonium carbonate are preferred.

Examples of the inorganic salts include sodium chloride-containing salts such as common salt, crude salt (co-salt), rock salt, sea salt, and natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, brine, and chloride Zinc, ammonium chloride; sodium sulfate, aluminum sulfate, aluminum / potassium sulfate (alum), aluminum / ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; 1Na ･ 2Na phosphate Sodium phosphates such as 3Na, potassium phosphates, calcium phosphates, and magnesium phosphates are preferred.

Examples of the ultraviolet absorber include p-aminobenzoic acid, p-aminobenzoic acid monoglyceride, N, N-dipropoxy p-aminobenzoic acid ethyl ester, and N, N-diethoxy p-aminobenzoic acid. Ethyl formate, N, N-dimethyl-p-aminobenzoate, N, N-dimethyl-p-aminobenzoate, N, N-dimethyl-p-aminobenzoate, etc. Benzoic acid-based ultraviolet absorber; N-ethylammonium o-aminobenzoic acid homomenthol ester and other o-aminobenzoic acid-based ultraviolet absorber; salicylic acid and its sodium salt, amyl salicylate, menthol salicylate Salicylic acid-based ultraviolet absorbers such as esters, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenylsalicylate; cinnamon Octanoate, ethyl-4-isopropylcinnamate, methyl-2,5-diisopropylcinnamate, ethyl-2,4-diisopropylcinnamate, methyl-2, 4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, 2- Ethylhexyl-p-methoxycinnamate (octyl p-methoxycinnamate), 2-ethoxyethyl-p-methyl Cinnamate (cinosalate), cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl-α-cyano- β-phenyl cinnamate (Oklin), glyceryl mono-2-ethylhexyl-di-p-methoxycinnamate, ferulic acid and its derivatives, cinnamic acid UV absorber; 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxy Benzophenone, 2,2 ', 4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (hydroxybenzophenone-3), 2-hydroxy-4 -Methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl- 4'-phenyl-benzophenone-2-carboxylic acid ester, 2-hydroxy-4-n-octyloxybenzophenone, 4-hydroxy-3-carboxybenzophenone, and other benzophenones UV absorber; 3- (4'-methylbenzylidene) -d, 1-camphor, 3-benzylidene-d, 1-camphor; 2-phenyl-5-methylbenzoxazole ; 2,2'-hydroxy-5-methylphenylbenzotriazole; 2- (2'-hydroxy-5'-t-octylphenyl) benzotriazole; 2- (2 ' -Hydroxy-5'-methylphenylbenzotriazole; dibenzylazine; dianisole-methane; 5- (3,3-dimethyl-2-norbornylidene) -3-pentane Alkan-2-one; 4-t-butylmethoxydibenzomethane derivatives, such as benzoylmethane derivatives; octyltriazinone; urocanic acid and urocanic acid ethyl ester Acid derivatives; 2- (2'-hydroxy-5'-methylphenyl) benzotriazole, 1- (3,4-dimethoxyphenyl) -4,4-dimethyl-1, Hydantoin derivatives such as 3-pentanedione, dimethoxybenzylidenedioximidazolidinepropionate, 2-ethylhexyl ester, phenylbenzimidazolesulfonic acid, p-xylylenediamine Camphor sulfonic acid, cresol triazole trisiloxane, methyl o-aminobenzoate, rutin and its derivatives, oryzanol and its derivatives are preferred.

Examples of the whitening agent include hydroquinone glycosides such as arbutin and α-arbutin, and esters thereof; ascorbic acid phosphate salts such as ascorbic acid, sodium ascorbyl phosphate and magnesium ascorbyl phosphate; and tetraisopalmitate ascorbate Ascorbic acid fatty acid esters, ascorbyl ethers such as ascorbyl ether, ascorbyl glucosides such as ascorbic acid-2-glucoside and their fatty acid esters, ascorbyl sulfate, tocopheryl phosphate ascorbate derivatives; ascorbic acid, Ellagic acid, tranexamic acid and its derivatives, ferulic acid and its derivatives, placental extract, glutathione, oryzanol, butylresorcinol, oil-soluble chamomile extract, oil-soluble licorice extract , Plant extracts such as willow extract, saxifraga, etc. are preferred.

Vitamins and their derivatives include retinol, retinol acetate, retinyl palmitate, and other vitamin A; thiamine hydrochloride, thiamine sulfate, riboflavin, and acetic acid Riboflavin, Pyridoxine Hydrochloride, Pyridoxine Dicaprylate, Pyridoxine Dipalmitate, Flavin Adenine Dinucleotide, Cyanocobalamin, Folic Acids, Nicotinamide Pyramine Vitamin B groups such as nicotinic acid and choline such as benzyl alkali; vitamin C such as ascorbic acid and its salts such as sodium; vitamin D; vitamin E such as α, β, γ, and δ-tocopherol Other; vitamins such as pantothenic acid, biotin; ascorbyl phosphate sodium salt and ascorbyl phosphate magnesium salt, ascorbyl phosphate, ascorbyl palmitate, stearic acid ascorbate, palmitate ascorbate, dipalmitate ascorbate Ascorbyl fatty acid esters, ascorbyl ethers such as ascorbyl ether, ascorbyl glucosides such as ascorbyl-2-glucoside and its fatty acid esters, ascorbic acid derivatives such as tocopheryl phosphate ascorbate; tocopheryl nicotinate, Vitamin derivatives acid tocopherol, tocopherol linoleic acid, ferulic acid, tocopherol, tocopheryl phosphate derivatives of tocopherol, the tocotrienols, derivatives of a variety of other vitamins are preferred.

Examples of hair growth agents / blood circulation promoters / stimulants include Japanese amaranth extract, capsicum annuum, ginger palate, ginger extract, cantharidis tincture, and other plant extracts / capsules; capsaicin , Nonyl Vanillylamide, Gingerone, Fishstone, Tannin, Borneol, Cyclomandelate, Cinnarizine, Tolazoline, Acetylcholine, Verapamil, Qianjinteng Vitamins, γ-oryzanol, vitamin E, and nicotinic acid tocopherol. Derivatives such as tocopherol acetate, γ-oryzanol, nicotinic acid and nicotinamide. Benzyl nicotinate. Derivatives such as phyticotinate, nicotinyl alcohol, allantoin, sensitizer 301, sensitizer 401, carprochloride, monoglyceryl pentarate, flavanol derivatives, stigmitol or Stigrolitol, its glycoside and minoxidil are preferred.

Examples of hormones include estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone, and the like. Examples of other medicinal agents such as anti-wrinkle agents, anti-aging agents, firming agents, cold-sensing agents, warm-sensing agents, wound healing accelerators, stimulants, analgesics, and cell-activating agents include retinols, Flavonic acid, retinoic acid tocopheryl ester; lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and its glycosides / esterification derivatives, hydroxydecanoic acid, long-chain α-hydroxy fatty acids, long-chain α- or β-fruit acids and their derivatives such as α-hydroxy fatty acid cholesterol; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; carnosine; creatine; neural crest Amines, sphingosine; caffeine, xanthine and their derivatives; coenzyme Q10, carotene, lycopene, astaxanthin, lutein, alpha-lipoic acid (Thioctic acid), colloidal platinum (Colloidal platinum), fullerenes and other antioxidant / active oxygen scavengers; catechins; quercetin and other flavonoids; isoflavones; gallic acid and ester sugar derivatives; tannin, sesamin, Plant anthocyanins, chlorogenic acids, apple polyphenols and other polyphenols; Rutin and glycoside derivatives; hesperidin and glycosides Other derivatives; quasi-lignin glycosides; Glycyrrhizin, Glycyrrhizin, Glycyrrhizin, Isoglycyrrhizin and other licorice extract-related substances; Lactoferrin; Gingerol, Gingerol; Menthol, Spice substances such as cedar alcohol and their derivatives; capsaicin, vanillin and their derivatives; insect repellents such as diethyltoluidine; and complexes of physiologically active substances and cyclodextrin are preferred.

Examples of plant / animal / microbial extracts include iris extract, ashitaba extract, arborvitae extract, asparagus extract, avocado extract, sweet tea extract, apricot tree extract, hollyhock extract, mountain gold Car Extract, Aloe Vera Extract, Apricot Extract, Apricot Kernel Extract, Ginkgo Extract, Artemisia Argyi Extract, Fennel Extract, Artemisia Argyi Extract, Turmeric Extract, Oolong Tea Extract, Bear Fruit Extract, Rosehip Extract, Echinacea Leaf Extract, Japanese Tea Plant Extract, Scutellaria Baicalensis Extract, Cork Extract, Coptis Extract, Barley Extract, Chinese Ginseng Extract, Little Forsythia Extract, Wild Sesame Extract, Red Miscanthus flower extract, broccoli extract, orange extract, seawater dried extract, seaweed extract, persimmon leaf extract, pyracantha extract, hydrolyzed elastin, hydrolyzed wheat flour, hydrolyzed silk, kudzu root extract, chamomile Extract, oil-soluble chamomile extract, carrot extract, wormwood extract, wild oat extract, kalkade extract, licorice extract, oil Licorice extract, kiwi extract, kioue extract, agaric extract, cinchona extract, cucumber extract, paulownia leaf extract, guanosine, guar extract, matrine extract, gardenia extract, vitamin Bear's bamboo extract, Sophora flavescens extract, walnut extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, black sugar extract, black vinegar, chlorella extract, mulberry Extract, yellow gentian extract, Geranium thunbergii extract, black tea extract, yeast extract, magnolia extract, coffee extract, burdock extract, rice extract, rice fermentation extract, Rice bran fermentation extract, rice germ oil, comfrey extract, collagen, bilberry extract, asarum extract, Bupleurum extract, umbilical cord extract, saffron extract, sage extract, soapgrass extract, Fine bamboo extract, wild hawthorn extract, silkworm sand extract, mountain pepper extract, shiitake mushroom extract, rehmannia glutinosa extract, purple root extract, perilla extract, East China tincture extract, spiraea extract, twin leaf extract Extract, Paeonia lactiflora extract, Ginger extract, Acorus calamus root extract, Birch extract, White fungus extract, Acacia extract, Stevia extract, Stevia fermented extract, Salix extract, Ivy extract , Sharp thorn hawthorn extract, western elderberry extract, yarrow extract, mint extract, sage extract, mallow extract, chuanxiong extract, japanese amaranth extract, mulberry extract , Rhubarb extract, soybean extract, jujube extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, white grass extract, tangerine peel extract, tea tree oil, sweet tea extract , Chili extract, angelica extract, calendula extract, peach kernel extract, wadi fish scale spruce extract, houttuynia cordata extract, tomato extract, natto extract, carrot extract, garlic extract, wild rose extract Extract, hibiscus extract, Ophiopogon extract, lotus extract, parsley extract, birch extract, honey, witch hazel extract, wall grass extract, blue cilantro Extract, bisabolol, Japanese cypress extract, bifidobacteria extract, coriander extract, butterbur extract, butterbur extract, Poria extract, pseudoleaf tree extract, grape extract, grape seed extract Extract, propolis, loofah extract, safflower extract, peppermint extract, linden extract, peony extract, hop extract, rose extract, pine extract, salsa extract, plantain extract, sapinensis extract, Melissa extract, aquatic extract, peach extract, cornflower extract, eucalyptus extract, saxifraga extract, grapefruit extract, lily extract, coix kernel extract, bonsai extract, lavender extract, Green Tea Extract, Eggshell Membrane Extract, Apple Extract, Linear Aspartal Tea Extract, Ganoderma Extract, Lettuce Extract, Lemon Extract, Forsythia Extract, Mirabilis Extract, Rose Extract, Fan Extract Extracts such as rosemary extract, roman chamomile extract, royal jelly extract, and elm extract are preferred.

Examples of the antipruritic agent include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, and substance P inhibitors.

Examples of the keratin peeling / dissolving agent include salicylic acid, sulfur, resorcinol, selenium sulfide, and pyridoxine.

Examples of the antiperspirant include aluminum chloride (Aluminum chloride), aluminum chloride, zinc oxide, and zinc p-phenolsulfonate.

Examples of the cooling agent include menthol and methyl salicylate.

Examples of the astringent include citric acid, tartaric acid, lactic acid, and aluminum sulfate. Potassium, tannic acid, etc.

Examples of the enzymes include superoxide dismutase, catalase, chlorolysozyme, lipase, papain, trypsin preparation, and protease.

As the nucleic acids, preferred are ribonucleic acid and its salts, deoxyribonucleic acid and its salts, and disodium adenosine triphosphate.

Examples of the fragrance include acetocedarene, pentylcinnamaldehyde, allylpentyl glycolate, β-ionone, Iso E Super, isobutylquinoline, iris oil, iris ketone, Indole, ylang ylang oil, undecalaldehyde, undecenal, γ-undecanolactone, artemisinin, eugenol, oakmoss, sweet red myrrh resin, orange oil, eugenol, neroli Vegetarian, galactosamine solid, carvacrol, L-carvone, camphor, canon, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranilon, isobornyl acetate, acetic acid fragrance Leaf esters, dimethyl benzyl acetate, threonyl acetate, cedar acetate, terpine acetate, p-tert-butyl cyclohexyl acetate, vetiver acetate, benzyl acetate, linalyl acetate , Isoamyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamen aldehyde, cyclopentadenolactone, methyl dihydrojasmonate, dihydromyrcenol, Jasmine Propolis, Jasmine lactone, cis-jasmone, citral, citronellol, citronellal, cinnamon oil, 1,8-eucalyptol, cinnamaldehyde, threonine Hexiang extract, cedar oil, cedarene, cedar alcohol, celery seed oil, thyme oil, dihydrodamascenone, damascenone, thymol, tuberose essence, decanal, caprolactone, terpenes Pinol, γ-terpinene, dimethyl-3-cyclohexene-1-carbaldehyde, nerol, nonanal, 2,6-nonadienol, nonyllactone, patchouli alcohol, vanillin , Vanillin, basil oil, patchouli oil, hydroxycitronellal, α-pinene, menthol, phenethyl alcohol, phenylacetaldehyde, bitter orange leaf oil, hexylcinnamaldehyde, cis-3-hexenol, Peru Balsam, vetiver oil, vetiver alcohol, peppermint oil, pepper oil, piperonal, bergamot oil, benzyl benzoate, borneol, myrrh essential oil, muscone, methylnonylacetaldehyde, γ-methylionone, menthol, L-menthol, L-menthol, eucalyptus oil, β-ionone, lime oil, lavender oil, D-1,8-terpene diene, linalool Synthetic and natural fragrances such as Lyral, Lily of the Valley, Lily of the Valley, Lemon Oil, Rose Essential Oil, Rose Ether, Rose Oil, Rosemary Oil, Various Essential Oils, and various blended spices are preferred.

Examples of the pigment / colorant / dye include brown 201, black 401, purple 201, purple 401, blue 1, blue 2, blue 201, blue 202, and blue 203. , Blue 204, blue 205, blue 403, blue 404, green 201, green 202, green 204, green 205, green 3, green 401, green 402, red 102, red 104-1, red 105-1, red 106, red 2, red 201, red 202, red 203, red 204, red 205, red 206, red 207 , Red 208, red 213, red 214, red 215, red 218, red 219, red 220, red 221, red 223, red 225, red 226, red 227, red 228, red 230-1, red 230-2, red 231, red 232, red 3, red 401, red 404, red 405, red 501, red 502, red 503 , Red 504, red 505, red 506, orange 201, orange 203, orange 204, orange 205, orange 206, Color 207, orange 401, orange 402, orange 403, yellow 201, yellow 202-1, yellow 202-2, yellow 203, yellow 204, yellow 205, yellow 4, yellow 401 No., Yellow 402, Yellow 403-1, Yellow 404, Yellow 405, Yellow 406, Yellow 407, Yellow 5 and other legal pigments; Acid Red 14 and other acid dyes; Arianor Sienna Brown, Basic dyes such as Arianor Madder Red, Arianor Steel Blue, Arianor Straw Yellow; HC Yellow 2, HC Yellow 5, HC Red 3, 4-hydoxypropylamino-3-nitrophenol, N, N'-bis (2-hydroxyethyl) -2 Nitro dyes such as -nitro-p-phenylenediamine, HC Blue 2, Basic Blue 26, etc .; disperse dyes; anthraquinones such as astaxanthin, alizarin, anthocyanidin, β-carotene, carrot Catalin, capsanthin, chalcone, safflorin, pentaflavonoids, crocetin, chlorophyll, curcumin, carmine, shikonin and other naphthoquinones, redwood, flavonoids, β-anthocyanins , Henna, hemoglobin, lycopene, riboflavin, Rutin and other natural colors . Dyes; p-phenylenediamine, toluene-2,5-diamine, o-, m-, or p-aminophenol, m-phenylenediamine, 5-amino-2-methylphenol, resorcinol , 1-naphthol, 2,6-diaminopyridine, etc. and their salts, oxidative dye intermediates and couplers; indoline and other auto-oxidative dyes; dihydroxyacetone is preferred.

Examples of the anti-inflammatory agent / anti-inflammatory agent include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, ligulin, guaiac, allantoin, indomethacin, and ketobulol Fen, ibuprofen, diclofenac, loxoprofen, celecoxib, infliximab, etanercept, zinc oxide, hydrocortisone acetate, dehydrocortisone, diphenhydramine hydrochloride , Chlorpheniramine maleate; plant extracts such as peach leaf extract and canopy leaf extract are preferred.

Examples of anti-asthma, anti-chronic obstructive pulmonary disease, antiallergy, and immunomodulators include amino theophylline, theophylline, steroids (fluticasone, beclomethasone, etc.), leukotriene antagonists, Thromboxane inhibitors, sodium cromoglycate, beta2 stimulants (formoterol, salmeterol, salbutamol, tobutrolol, clenbuterol, adrenaline, etc.), tiotropium, ipratropium, Dextromethorphan, dimethylmorphane, bromhexine, tranilast, ketotifen, azelastine, cetirizine, chlorpheniramine, mequitazine, tacrolimus, cyclosporin Peptin, sirolimus, methotrexate, cytokine regulators, interferon, omazumab, and protein / antibody preparations are preferred.

As an anti-infective agent and an antifungal agent, oseltamivir, zanamivir, and itraconazole are preferable. In addition, there are well-known combinations and formulation ratios / dosage ratios that contain cosmetic raw material standards, specifications for the composition of cosmetic types, the Japan Cosmetics Industry Federation ingredient name list, the INCI dictionary (The International Cosmetic Ingredient Dictionary and Handbook), and the Ministry of Medicine. Ingredients and international patent classification IPC belonging to the classification of A61K7 and A61K8 in Japanese and international patent publications and patent publications (including public announcements) , Re-publication table) and other well-known cosmetic ingredients, pharmaceutical ingredients, food ingredients, and the like.

[Manufacturing method of dispersion liquid] 分散 The dispersion liquid of the present invention can be a lipid peptide type formed by using at least one of the compounds represented by the aforementioned formulae (1) to (3) or a pharmaceutically acceptable salt thereof. Dispersant for pigment or powder composed of compound, surfactant, water, 1,2-alkanediol or 1,3-alkanediol, fatty acid, and at least one selected from the group consisting of pigment and powder One kind and other additives such as a desired polyol are produced by mixing and stirring these while heating, and then stirring and cooling to about room temperature.

For example, the dispersion liquid of the present invention is produced by the following steps. a) the step of preparing the pigment or powder dispersant (lipid peptide compound), a surfactant, and water, and heating to prepare a dissolving solution (or dispersing solution); b) adding the dissolving solution (or dispersing solution) to water, The step of heating at a temperature of not less than 100 ° C above room temperature, c) the step of obtaining the dispersion liquid of the present invention while cooling to a temperature lower than the temperature in the aforementioned heating step while stirring. Here, 1,2-alkanediol or 1,3-alkanediol, fatty acids, at least one selected from the group consisting of pigments and powders, and other components can be dissolved in step a). In the preparation step of the liquid (or dispersion), it may also be added in advance to the water to which the dissolving solution (or dispersion) is added in step b). Furthermore, it is preferable that the water is 60% by mass or more and 99.9% by mass or less with respect to the total mass of the dispersion liquid of the present invention (including at least one selected from the group consisting of pigments and powders).

The heating temperature in the foregoing steps a) and b) is preferably 50 ° C to 90 ° C, more preferably 60 ° C to 90 ° C, such as 80 ° C, and it is preferable to perform stirring while heating. At this time, the heating and stirring time in each step depends on the type of pigment and powder dispersant (lipid peptide compound) or surfactant, and the types of other components and their blending amounts. Usually, it can be from 1 minute to Dissolve and disperse in about 50 minutes. (I) Steps (a) and (b) are followed by cooling (step (c)) while stirring until the liquid temperature becomes lower than the temperature in step b). Here, the cooling temperature is, for example, about room temperature to 80 ° C, room temperature to 60 ° C, or room temperature to about 40 ° C.

In addition, after the aqueous composition of the present invention is prepared as a premix, the premix may be produced by suitably adding other components to the premix. For example, the following methods can be used as a method for producing a dispersion after premixing. 1) Step 1-1 of preparing a premix: a surfactant and water and a dispersant for a pigment or a powder (the compound represented by the aforementioned formula (1) to formula (3) or a pharmaceutically acceptable salt thereof) A mixture of at least one of the lipid peptide compounds formed), a heating step of heating to a temperature above room temperature and not more than 100 ° C, 1-2), and then, to the aforementioned mixed system after heating, it is suitable to add Step of 1,2-alkanediol or 1,3-alkanediol, fatty acid and other additives, 1-3) The step of preparing the aqueous solution (premix) by cooling the aforementioned dissolving solution or dispersion, 2 ) Step 2-1 of preparing a dispersion using a premix 2-1) In the water phase heated to a temperature above room temperature and not higher than 100 ° C, add the above-mentioned aqueous composition (preliminarily heated to a temperature above room temperature and less than 100 ° C) (Mixture), mixed or added to the above-mentioned aqueous composition (premix) heated to a temperature above room temperature and not more than 100 ° C, adding an aqueous phase heated to a temperature above room temperature and less than 100 ° C, and mixed The mixing step, 2-2) the obtained mixing step The mixture was cooled by stirring to obtain a cooling step of the dispersion.水 The water phase in the above step 2-1) contains water, and may further contain higher alcohols, pigments, and may also include 1,2-alkanediol or 1,3-alkanediol, fatty acids, and other additives. In addition, in 2-1), a pigment or other additives may be mixed with an aqueous composition (premix), and then it may be combined with water. In addition, in the mixing step, a pharmaceutical-added dispersion liquid (formulation) can also be produced by further adding a pharmaceutical solution.

The heating temperature of the mixing system (and the aqueous composition) in the foregoing steps 1-1) and 1-2) is preferably 50 ° C to 90 ° C, and more preferably 60 ° C to 90 ° C, such as 70 ° C or 80 ° C. . This step is preferably carried out while stirring. The time for heating (stirring) in each step at this time varies depending on the type of pigment or powder dispersant (lipid peptide compound) or surfactant other than the ingredients contained in the aqueous composition, and their blending amounts. , Usually 5 minutes to 50 minutes. With this step, a state in which the aqueous composition is uniformly dissolved is obtained. In addition, the cooling temperature in the foregoing steps 1-3) is, for example, about room temperature to 80 ° C, room temperature to 60 ° C, or room temperature to about 40 ° C. In this step, it is preferable to cool while stirring, and then, after stirring is stopped, it is better to stand still. In addition, it is preferable that the water is 30 mass% or more and less than 80 mass% with respect to the total mass of the aqueous composition (premix) obtained in step 1).

The heating temperature of the aqueous phase and the aqueous composition (premix) in the aforementioned step 2-1) is preferably 50 ° C to 90 ° C, more preferably 60 ° C to 90 ° C, such as 70 ° C, or 80 ° C, or 90 ° C. Since the heating of the water phase contains other components, it is preferable to heat it while stirring, until the contained components are uniformly dissolved and dispersed, and it is usually preferable to perform heating (stirring) for about 1 to 50 minutes. The heating temperature of the water phase may be the same as the heating temperature of the aqueous composition (premix).

Next, in the aforementioned step 2-2), the mixture obtained in the previous step is stirred and cooled to obtain a dispersion liquid. When cooling with stirring, for example, stirring may be performed until the cooling temperature reaches room temperature to 80 ° C and room temperature to 60 ° C, for example, about 60 ° C, and then the stirring may be stopped, left to stand, and cooled.

Even in the dispersion obtained by using the aqueous composition (premix) in this manner, the amount of water to be formulated is preferably 60% by mass or more and 99.9% by mass or less with respect to the total mass of the dispersion. [Example]

The following examples and test examples are taken as examples to describe the present invention in detail, but the present invention is not limited to these examples.

[Synthesis Example 1: Synthesis of Lipid Peptide (N-palmidine-Gly-His)] The lipid peptide-type compound used in this example was synthesized by the method shown below. In a 500 mL four-necked flask, put 14.2 g (91.6 mmol) of histidine, 30.0 g of N-palmidine-Gly-methyl (91.6 mmol), and 300 g of toluene, and then add 35.3 g of a sodium 28% methanol solution in alkali. (183.2 mmol), heated to 60 ° C using an oil bath, and continued stirring for 1 hour. Then, the oil bath was removed, and it was left to cool to 25 ° C. This solution was reprecipitated with 600 g of acetone and filtered to obtain it. This obtained solid was dissolved in a mixed solution of 600 g of water and 750 g of methanol, and 30.5 ml (183.2 mmol) of 6N (predetermined degree) hydrochloric acid was added thereto to neutralize and precipitate a solid, followed by filtration. Next, the obtained solid was dissolved in a mixed solution of 120 g of tetrahydrofuran and 30 g of water, dissolved at 60 ° C, 150 g of ethyl acetate was added, and the temperature was cooled from 60 ° C to 30 ° C. Then, the precipitated solid was filtered. The obtained solid was dissolved in a solvent of 120 g of tetrahydrofuran and 60 g of acetonitrile, heated to 60 ° C., stirred for 1 hour, and then cooled and filtered. The solid obtained here was washed with 120 g of water, filtered and dried under reduced pressure to obtain 26.9 g of white crystals of N-palmidine-Gly-His free form (hereinafter also referred to as Pal-GH) (collected Rate 65%).

[Example 1: Preparation of 10% by mass pigment liquid foundation] According to the following Table 1, a 10% by mass pigment liquid foundation was prepared. In a Laboran standard bottle (No. 7, AS ONE), 5.0 g of pigment and 33.0 g of pure water were stirred at 80 ° C for 2 minutes, and 1,2-hexanediol 1.0 heated to 80 ° C was added here. g, stirring and mixing for 2 minutes. Here, 1.0 g of the composition [1] which has been heated to 80 ° C. is added and stirred for 2 minutes, and then 10.0 g of glycerin which has been heated to 80 ° C. is added and stirred for 3 minutes. In this state, it is stirred and cooled to become a chamber. Warm to get liquid foundation. In addition, the composition [1] has the composition shown in Table 1. Pal-GH, polyoxyethylene lauryl ether, and pure water were mixed, and the mixture was heated to 70 ° C, and 1,2-hexanediol and stearic acid were added thereto. After heating and stirring at 70 ° C, it is obtained by leaving to cool to room temperature. The composition [1] obtained by the same procedure was used in the following examples.搅拌 Stirring in the above manufacturing steps was performed at 400 rpm.

[Example 2: Preparation of foundation liquid with 10% by mass of pigment] Except that the composition [1] is 0.5 g and pure water is 33.5 g, the same procedures as in Example 1 were used to manufacture the formulation as shown in Table 1. Liquid foundation with 10% by mass of pigment.

[Example 3: Preparation of 15% by weight pigment base liquid preparation] Except that the pigment was 7.5g and pure water was 31g, the same procedure as in Example 2 was used to produce a 15% by weight pigment base powder as shown in Table 1. Liquid foundation.

[Comparative Example 1] In the same procedure as in Example 1 except that the composition [1] was not prepared and pure water was 34.0 g, a foundation of a comparative example prepared with a pigment of 10% by mass as shown in Table 1 was produced.

FIG. 1 shows foundations (appearances) of Examples 1 to 3 and Comparative Example 1. FIG. (1) As shown in FIG. 1, in Examples 1 to 3 in which the composition [1] containing Pal-GH was prepared, the pigment was dispersed, and the dispersion stability of the pigment was confirmed. In addition, by adjusting the blending amount of the composition [1] containing Pal-GH, a liquid foundation type with high viscosity (Example 1) and a foundation type with lower viscosity (Example 2) can be prepared. And Example 3). In addition, in Comparative Example 1 in which the composition [1] containing Pal-GH was not prepared, as shown in FIG. 1, the pigment was separated from other components and the pigment was precipitated.

[Example 4: Preparation of 2% by mass of pearlescent pigment dispersion] According to the following Table 2, a 2% by mass of pearlescent pigment dispersion was prepared. In a Laboran standard bottle (No. 7, AS ONE), 1.0 g of pearlescent pigment and 33.5 g of pure water were stirred at 80 ° C for 2 minutes, and 1,3-butanediol heated to 80 ° C was added here. (1,3-butanediol) 5.0 g, and stirred and mixed for 2 minutes. Here, 0.5 g of the composition [1] heated to 80 ° C. is added, and the mixture is stirred and mixed for 2 minutes. Then, 10.0 g of glycerin heated to 80 ° C. is added, and stirred and mixed for 3 minutes. In this state, it is stirred and cooled to become a chamber. Warm to obtain a dispersion.搅拌 Stirring in the above manufacturing steps was performed at 400 rpm.

[Example 5: Preparation of 0.5% by mass of pearlescent pigment dispersion] According to the following Table 2, a 0.5% by mass of pearlescent pigment dispersion was prepared. In a Laboran standard bottle (No.7, AS ONE), stir 0.25g of pearlescent pigment and 49.25g of pure water at 80 ° C for 2 minutes, and then add the composition heated to 80 ° C [1] 0.5 g, After stirring and mixing for 2 minutes, the mixture was stirred and cooled to room temperature in this state to obtain a dispersion.搅拌 Stirring in the above manufacturing steps was performed at 400 rpm.

[Comparative Example 2] A dispersion liquid of a comparative example in which 2% by mass of a pearlescent pigment was prepared as shown in Table 2 was produced in the same procedure as in Example 4 except that the composition [1] was not prepared and pure water was 34.0 g.

FIG. 2 shows the dispersion liquid (appearance) of the pearlescent pigments prepared in Example 4 and Example 5 and Comparative Example 2. FIG. As shown in FIG. 2, in Comparative Example 2 in which the composition [1] containing Pal-GH was not formulated, the pearlescent pigment was separated from other components, and the pearlescent pigment was precipitated. However, in the example in which the composition [1] was formulated, As a result, in 4 and Example 5, the dispersibility of the pearlescent pigment was improved.

[Example 6: Preparation of Tricalcium Phosphate Dispersion Liquid] According to the following Table 3, a 0.5% by mass dispersion of tricalcium phosphate was prepared. In a Laboran standard bottle (No.7, AS ONE), stir 0.25g of tricalcium phosphate and 49.25g of pure water at 80 ° C for 2 minutes, and add the composition heated to 80 ° C [1] 0.5 g, After stirring and mixing for 2 minutes, the mixture was stirred and cooled to room temperature in this state to obtain a dispersion.搅拌 Stirring in the above manufacturing steps was performed at 400 rpm.

[Comparative Example 3] In the same procedure as in Example 5, except that the composition [1] was not prepared, and pure water was 49.75 g, a dispersion liquid of a comparative example prepared with tricalcium phosphate 0.5% by mass as shown in Table 3 was prepared. .

FIG. 3 shows the dispersion liquid (appearance) of the prepared tricalcium phosphate in Example 6 and Comparative Example 3. FIG. As shown in FIG. 3, in Comparative Example 3 in which the composition [1] containing Pal-GH was not formulated, tricalcium phosphate was separated from other components and tricalcium phosphate was precipitated, but when the composition [1] was prepared, As a result of Example 6, the dispersibility of tricalcium phosphate was improved.

[Example 7: Preparation of 0.01% by mass dispersion of gold foil] Prepare a 0.01% by mass dispersion of gold foil (about 2mm square to 10mm square) according to Table 4 below. In a Laboran standard bottle (No. 7, AS ONE), stir 5 mg of gold foil and 49.745 g of pure water at 80 ° C for 2 minutes, and add 0.25 g of the composition [1] which has been heated to 80 ° C, and proceed After stirring and mixing for 2 minutes, the mixture was stirred and cooled to room temperature in this state to obtain a dispersion.搅拌 Stirring in the above manufacturing steps was performed at 400 rpm.

[Example 8: Preparation of a dispersion of 0.05% by mass of gold foil] Except for 25 mg of gold foil, 0.5 g of the composition [1], and 49.475 g of pure water, the same steps as in Example 7 were used to manufacture, as shown in Table 4 As shown, a dispersion of 0.05% by mass of gold foil was prepared.

[Comparative Example 4] A dispersion liquid of Comparative Example prepared with 0.01% by mass of gold foil as shown in Table 4 was prepared in the same procedure as in Example 7 except that the composition [1] was not prepared and pure water was 49.95 g.

FIG. 4 shows the dispersion liquid (appearance) of the prepared gold foil in Example 7 and Example 8 and Comparative Example 4. FIG. As shown in FIG. 4, in Comparative Example 4 in which the composition [1] containing Pal-GH was not prepared, the gold foil was separated from other components, and the gold foil floated or precipitated due to its weight. However, the composition [1] ] In Examples 7 and 8, the dispersibility of tricalcium phosphate was improved. At this time, by adjusting the compounding amount of the composition [1] containing Pal-GH, the compounding amount of gold foil or the transparency of the dispersion liquid can be adjusted as a result.

[Example 9: Production of O / W foundation liquid with 17% by mass of pigment] According to Table 5 below, a foundation with 17% by mass of pigment uniformly dispersed was prepared. In a 200 mL beaker (manufactured by HARIO Co., Ltd.), 34.0 g of fresh color base AQUA, 139.6 g of pure water, and sodium N-stearylmethyltaurine (NIKKOL SMT, NIKKO CHEMICALS (shares)) 0.2 g, lecithin (LPA, NIKKO CHEMICALS (stock)) 0.2 g, EDTA-2Na (pure chemical (stock)) 0.2 g, hydroxypropyl cellulose (NISSO SSL, Japan Soda (stock)) 0.4 g, 0.4 g of xanthan gum (KELTROL-CG-ST, tricrystal (strand)) was heated and stirred at 75 ° C for 10 minutes (phase B). In a 200mL beaker (HARIO Co., Ltd.), add 4.0g of NIKKOL NIKKOMULESE41 (NIKKO CHEMICALS (shares)), 14.0g of NIKKOL NATURAL OILS (NIKKO CHEMICALS (shares)), 1.0g of NIKKOL NIKKOGUARD 88 (NIKKO CHEMICALS (shares)), Heat and stir at 75 ° C for 10 minutes (phase A).相 Add phase A to phase B with slow stirring, and use a homogenizer (QUICK HOMO MIXER LR-1A, manufactured by Mizuho Industrial Co., Ltd.) at 75 ° C. to perform an emulsification treatment at 5,000 rpm for 3 minutes. Then, 2.0 g of the composition [1] heated to 75 ° C. was added, and after heating and stirring at 75 ° C. for 2 minutes, the mixture was cooled to 40 ° C. with stirring at room temperature. After confirming that it was 40 ° C, 4.0 g (C phase) of NIKKOL NET-813-1 (NIKKO CHEMICALS (stock)) was added, and the mixture was cooled to 35 ° C with stirring.搅拌 In the above steps, stirring was performed at 200 rpm.

[Comparative Example 5] 17 A powder foundation having a mass of 17% by mass was prepared in accordance with Table 5 below. In a 200 mL beaker (manufactured by HARIO Co., Ltd.), 34.0 g of fresh color base AQUA, 139.6 g of pure water, and sodium N-stearylmethyltaurine (NIKKOL SMT, NIKKO CHEMICALS (shares)) 0.2 g, lecithin (LPA, NIKKO CHEMICALS (stock)) 0.2 g, EDTA-2Na (pure chemical (stock)) 0.2 g, hydroxypropyl cellulose (NISSO SSL, Japan Soda (stock)) 0.4 g, 0.4 g of xanthan gum (KELTROL-CG-ST, tricrystal (strand)) was heated and stirred at 75 ° C for 10 minutes (phase B). In a 200 mL beaker (HARIO Co., Ltd.), add NIKKOL NIKKOMULESE41 (NIKKO CHEMICALS (stock)) 4.0g, NIKKOL NATURAL OILS (NIKKO CHEMICALS (stock)) 14.0g, NIKKOL NIKKOGUARD 88 (NIKKO CHEMICALS (stock)) 1.0g, Heat and stir at 75 ° C for 10 minutes (phase A).相 Add phase A to phase B with slow stirring, and use a homogenizer (QUICK HOMO MIXER LR-1A, manufactured by Mizuho Industrial Co., Ltd.) at 75 ° C. to perform an emulsification treatment at 5,000 rpm for 3 minutes. Then, it stirred-cooled to 40 degreeC at room temperature, 4.0 g (C phase) of NIKKOL NET-813-1 (NIKKO CHEMICALS (stock)) was added, and it stirred-cooled to 35 degreeC.搅拌 In the above steps, stirring was performed at 200 rpm.

Fig. 5 shows the results of pigment dispersibility evaluation of the O / W foundation liquids of Example 9 and Comparative Example 5 obtained by observing (photographs) a polarizing microscope (manufactured by Olympus). As shown in FIG. 5, in Comparative Example 5 in which the composition [1] containing Pal-GH was not formulated, many pigments were observed to aggregate, and as a result, the dispersion became uneven, but implementation of the composition [1] As a result of Example 9, the dispersibility of the pigment was improved.

FIG. 6 shows the O / W liquid foundation (appearance) of Example 9 and Comparative Example 5 after the liquid foundation was prepared and left to stand for one month. As shown in FIG. 6, in Comparative Example 5 in which the composition [1] containing Pal-GH was not formulated, separation of pigment or oil was observed (in the figure, the state of separation was observed as color unevenness), and the dispersibility was obtained. It became uneven, but in Example 9 in which the composition [1] was formulated, the dispersibility of the pigment was improved as a result.

[Fig. 1] Fig. 1 shows 10% by mass of pigments prepared in Examples 1 to 3 and Comparative Example 1 (Example 1, Example 2 and Comparative Example 1) and 15% by mass of pigments (Example 3) ) Of the foundation (Foundation) of the picture. [Fig. 2] Fig. 2 is a diagram showing the appearance of a dispersion liquid prepared by blending pearlescent pigments prepared in Example 4, Example 5, and Comparative Example 2. [Fig. 3] Fig. 3 is a diagram showing the appearance of the dispersion liquid prepared with tricalcium phosphate prepared in Example 6 and Comparative Example 3. [FIG. 4] FIG. 4 is a diagram showing the appearance of a dispersion of gold foil prepared in Example 7, Example 8, and Comparative Example 4. FIG. [Fig. 5] Fig. 5 shows the observation results (photographs) of a polarizing microscope of the O / W foundation liquid (Liquid Foundation) prepared in Example 9 and Comparative Example 5. [Fig. 6] Fig. 6 is a diagram showing the appearance of the O / W foundation liquid prepared in Example 9 and Comparative Example 5 after one month of preparation.

Claims (9)

A dispersion liquid comprising: a surfactant, water, a lipid-peptide compound formed from at least one of a compound represented by the following formulae (1) to (3) or a pharmaceutically acceptable salt thereof A dispersant for pigment or powder, 1,2-alkanediol or 1,3-alkanediol, at least one fatty acid, and at least one selected from the group consisting of pigment and powder, (In the formula, R ¹ represents an aliphatic group having 9 to 23 carbon atoms, R ² represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms which may have a branched chain of 1 or 2 carbon atoms, and R ³ represents -(CH ₂ ) nX group, n represents a number of 1 to 4, X represents an amine group, a guanidino group, a -CONH ₂ group, or a 5-membered ring or a 6-membered ring or a 5-membered ring which may have 1 to 3 nitrogen atoms (Condensed heterocyclic ring consisting of 6-membered ring) (In the formula, R ⁴ represents an aliphatic group having 9 to 23 carbon atoms, and R ⁵ to R ⁷ each independently represent a hydrogen atom and an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms. Or-(CH ₂ ) nX group, and at least one of R ⁵ to R ⁷ represents a-(CH ₂ ) nX group, n represents a number from 1 to 4, and X represents an amine group, a guanidino group, and -CONH ₂ Or a 5-membered ring or 6-membered ring which may have 1 to 3 nitrogen atoms or a condensed heterocyclic ring composed of a 5-membered ring and a 6-membered ring) (In the formula, R ⁸ represents an aliphatic group having 9 to 23 carbon atoms, and R ⁹ to R ¹² each independently represent a hydrogen atom and an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms. Or-(CH ₂ ) nX group, and at least one of R ⁹ to R ¹² represents a-(CH ₂ ) nX group, n represents a number of 1 to 4, X represents an amine group, a guanidino group, and -CONH ₂ Or a 5-membered ring or 6-membered ring having 1 to 3 nitrogen atoms or a condensed heterocyclic ring composed of a 5-membered ring and a 6-membered ring). For example, the dispersion liquid of claim 1, wherein the at least one selected from the group consisting of pigments and powders is based on the total mass of the dispersion liquid and contains a ratio of 25% by mass or less. For example, the dispersion liquid according to claim 1 or claim 2, wherein the aforementioned dispersant for pigment or powder contains a ratio of 0.01% by mass to 1% by mass based on the total mass of the dispersion. The dispersion according to any one of claims 1 to 3, further comprising a polyhydric alcohol. The dispersion of claim 4, wherein the aforementioned polyol is glycerin. The dispersion according to any one of claim 1 to claim 5, wherein the aforementioned surfactant is selected from the group consisting of glycol alkyl ethers, phospholipids, polyglycerol fatty acid esters, and polyoxyethylene polyoxypropylene alkyl ethers. One or more compounds in the group. The dispersion according to any one of claim 1 to claim 6, wherein the fatty acid is stearic acid. The dispersion liquid according to any one of claim 1 to claim 7, which is a dispersion liquid for cosmetics. A dispersant for pigments or powders, which is a lipopeptide compound formed from at least one of the compounds represented by the following formulae (1) to (3) or a pharmaceutically acceptable salt thereof, (In the formula, R ¹ represents an aliphatic group having 9 to 23 carbon atoms, R ² represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms which may have a branched chain of 1 or 2 carbon atoms, and R ³ represents -(CH ₂ ) nX group, n represents a number of 1 to 4, X represents an amine group, a guanidino group, a -CONH ₂ group, or a 5-membered ring or a 6-membered ring or a 5-membered ring which may have 1 to 3 nitrogen atoms (Condensed heterocyclic ring consisting of 6-membered ring) (In the formula, R ⁴ represents an aliphatic group having 9 to 23 carbon atoms, and R ⁵ to R ⁷ each independently represent a hydrogen atom and an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms. Or-(CH ₂ ) nX group, and at least one of R ⁵ to R ⁷ represents a-(CH ₂ ) nX group, n represents a number from 1 to 4, and X represents an amine group, a guanidino group, and -CONH ₂ Or a 5-membered ring or 6-membered ring which may have 1 to 3 nitrogen atoms or a condensed heterocyclic ring composed of a 5-membered ring and a 6-membered ring) (In the formula, R ⁸ represents an aliphatic group having 9 to 23 carbon atoms, and R ⁹ to R ¹² each independently represent a hydrogen atom and an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms. Or-(CH ₂ ) nX group, and at least one of R ⁹ to R ¹² represents a-(CH ₂ ) nX group, n represents a number of 1 to 4, X represents an amine group, a guanidino group, and -CONH ₂ Or a 5-membered ring or 6-membered ring having 1 to 3 nitrogen atoms or a condensed heterocyclic ring composed of a 5-membered ring and a 6-membered ring).