JPWO2018190383A1 - Dispersion containing pigment or powder dispersant - Google Patents

Abstract

An object of the present invention is to provide a dispersion liquid and a dispersant which can prevent separation and sedimentation of a pigment or the like over time in a dispersion liquid containing a pigment or powder. A pigment or powder dispersant comprising a lipid peptide-type compound comprising at least one of a compound represented by the following formula (1) and its analogous compound or a pharmaceutically usable salt thereof: A dispersion including the surfactant and water, a 1,2-alkanediol or a 1,3-alkanediol, a fatty acid, and at least one selected from the group consisting of a pigment and a powder, and the dispersion and the pigment or the powder. Dispersant. Wherein R 1 represents an aliphatic group having 9 to 23 carbon atoms, and R 2 represents a hydrogen atom or a C 1 to C 4 carbon atom which may have a branched chain having 1 or 2 carbon atoms. Represents an alkyl group, R3 represents a-(CH2) nX group, n represents a number of 1 to 4, and X has 1 to 3 amino groups, guanidino groups, -CONH2 groups, or 1 to 3 nitrogen atoms. Represents the resulting 5- or 6-membered ring or a fused heterocycle composed of a 5- and 6-membered ring.)

Description

  The present invention relates to a dispersion containing a pigment or powder dispersant, and more particularly, to a dispersion containing a pigment or powder dispersant composed of a lipid peptide-type compound and to the pigment or powder dispersant.

Aqueous compositions can be used for cosmetics, etc., because they provide a high refreshing feeling when applied to the skin, etc., and they are less sticky after use than oily compositions and have a dry feel. Products are marketed and proposed.
For example, as a solid aqueous composition, conventionally, a solid oil-in-water makeup cosmetic containing water, a fatty acid soap, an oil component and a powder (Patent Document 1), an alkyl and / or alkenyl oligoglycoside, an oily substance, and a nonionic compound A stick-shaped aqueous cosmetic containing an emulsifier (Patent Document 2) has been proposed.
As the liquid aqueous composition, there have been proposed a large number of aqueous cosmetic compositions in which various additives such as a humectant and the like are mainly composed of water and an emulsion type composition in which an emulsifier is mixed with an oil component and an aqueous component. Have been.

JP-A-3-279319 JP 2002-516818 A

For the aqueous cosmetics described above, for example, many products containing various pigments and powders for coloring the skin have been proposed. However, when such aqueous cosmetics are left standing for a long time, the pigments and powders are separated.・ Settles down and may form a hard cake in some cases.
For this reason, proposals for stabilizing the dispersion by blending additives such as various resins, thickeners, and dispersants have been studied, and the separation and sedimentation of pigments and powders, and their aggregation and solidification have been improved. Technical proposals that can be suppressed are required.

  The present invention has been made based on the above circumstances, and a problem to be solved is a dispersion liquid and a dispersant which can prevent separation and sedimentation of pigments and the like over time in a dispersion liquid containing a pigment or powder. It is to provide.

  The present inventors have conducted intensive studies to solve the above problems, and as a result, a dispersion using a lipid peptide-type compound comprising a low-molecular lipid peptide or a pharmaceutically usable salt thereof as a pigment or a powder dispersant. In the above, it was found that a dispersion liquid in which separation and sedimentation over time of the blended pigment and the like were suppressed was obtained, and the present invention was completed.

That is, the present invention provides, as a first aspect,
A surfactant;
water and,
A pigment or powder dispersant comprising a lipid peptide-type compound comprising at least one of the compounds represented by the following formulas (1) to (3) or a pharmaceutically usable salt thereof;
1,2-alkanediol or 1,3-alkanediol;
At least one fatty acid,
Including at least one selected from the group consisting of pigments and powders,
Related to the dispersion.
(Wherein, R ¹ represents an aliphatic group having 9 to 23 carbon atoms, and R ² represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms. R ³ represents a — (CH ₂ ) n —X group, n represents a number of 1 to 4, and X represents 1 to 3 amino groups, guanidino groups, —CONH ₂ groups, or 1 to 3 nitrogen atoms. Represents a 5-membered or 6-membered ring or a condensed heterocyclic ring composed of a 5-membered ring and a 6-membered ring.)
(Wherein, R ⁴ represents an aliphatic group having 9 to 23 carbon atoms, and R ^{5 to} R ⁷ each independently represent a hydrogen atom, a carbon atom which may have a branched chain having 1 or 2 carbon atoms). 1 to 4 alkyl groups, or represents - _(CH 2) n-X group, and at least one of ^{R 5} to ^{R 7} are - _(CH 2) represents an n-X group, n represents 1 to 4 X represents an amino group, a guanidino group, a -CONH ₂ group, or a 5- or 6-membered ring having 1 to 3 nitrogen atoms, or a fused heterocyclic ring composed of a 5- and 6-membered ring. Represents a ring.)
(Wherein, R ⁸ represents an aliphatic group having 9 to 23 carbon atoms, and R ^{9 to} R ¹² each independently represent a hydrogen atom, a carbon atom which may have a branched chain having 1 or 2 carbon atoms). 1 to 4 alkyl groups, or represents - _(CH 2) n-X group, and at least one of ^{R 9} or ^{R 12} is - _(CH 2) represents an n-X group, n represents 1 to 4 X represents an amino group, a guanidino group, a -CONH ₂ group, or a 5- or 6-membered ring having 1 to 3 nitrogen atoms, or a fused heterocyclic ring composed of a 5- and 6-membered ring. Represents a ring.)
As a second aspect, the dispersion according to the first aspect, wherein at least one selected from the group consisting of the pigment and the powder is contained in a proportion of 25% by mass or less based on the total mass of the dispersion. About.
As a third aspect, the pigment or powder dispersant is contained in a proportion of 0.01% by mass to 1% by mass based on the total mass of the dispersion, and is described in the first or second aspect. Dispersion.
As a fourth aspect, the present invention relates to the dispersion according to any one of the first to third aspects, further including a polyhydric alcohol.
As a fifth aspect, the present invention relates to the dispersion according to the fourth aspect, wherein the polyhydric alcohol is glycerin.
As a sixth aspect, the surfactant is one or more compounds selected from the group consisting of ethylene glycol alkyl ether, phospholipid, polyglycerin fatty acid ester and polyoxyethylene polyoxypropylene alkyl ether. To a dispersion according to any one of the first to fifth aspects.
As a seventh aspect, the present invention relates to the dispersion according to any one of the first to sixth aspects, wherein the fatty acid is stearic acid.
As an eighth aspect, the present invention relates to the dispersion according to any one of the first to seventh aspects, which is a dispersion for cosmetics.
As a ninth aspect, the present invention relates to a pigment or a powder dispersant comprising a lipid peptide-type compound comprising at least one of the compounds represented by the following formulas (1) to (3) or a pharmaceutically usable salt thereof. .
(Wherein, R ¹ represents an aliphatic group having 9 to 23 carbon atoms, and R ² represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms. R ³ represents a — (CH ₂ ) n —X group, n represents a number of 1 to 4, and X represents 1 to 3 amino groups, guanidino groups, —CONH ₂ groups, or 1 to 3 nitrogen atoms. Represents a 5-membered or 6-membered ring or a condensed heterocyclic ring composed of a 5-membered ring and a 6-membered ring.)
(Wherein, R ⁴ represents an aliphatic group having 9 to 23 carbon atoms, and R ^{5 to} R ⁷ each independently represent a hydrogen atom, a carbon atom which may have a branched chain having 1 or 2 carbon atoms). 1 to 4 alkyl groups, or represents - _(CH 2) n-X group, and at least one of ^{R 5} to ^{R 7} are - _(CH 2) represents an n-X group, n represents 1 to 4 X represents an amino group, a guanidino group, a -CONH ₂ group, or a 5- or 6-membered ring having 1 to 3 nitrogen atoms, or a fused heterocyclic ring composed of a 5- and 6-membered ring. Represents a ring.)
(Wherein, R ⁸ represents an aliphatic group having 9 to 23 carbon atoms, and R ^{9 to} R ¹² each independently represent a hydrogen atom, a carbon atom which may have a branched chain having 1 or 2 carbon atoms). 1 to 4 alkyl groups, or represents - _(CH 2) n-X group, and at least one of ^{R 9} or ^{R 12} is - _(CH 2) represents an n-X group, n represents 1 to 4 X represents an amino group, a guanidino group, a -CONH ₂ group, or a 5- or 6-membered ring having 1 to 3 nitrogen atoms, or a fused heterocyclic ring composed of a 5- and 6-membered ring. Represents a ring.)

According to the present invention, by using a lipid peptide-type compound as a dispersant for pigments or powders, the pigments or powders are not separated or settled from the dispersion over time, and these are stably dispersed. It can be a dispersed liquid.
In particular, by using the dispersant of the present invention, a stable dispersion can be prepared even when the pigment is compounded in an amount of 10% by mass or more or a relatively large powder such as a gold foil is compounded.

The lipid peptide compound constituting the dispersant of the present invention is a very safe artificial low-molecular compound composed of only lipid and peptide.
Further, various components contained as additives in the dispersion of the present invention are general-purpose additives as additives for foods, cosmetics, and pharmaceuticals.
That is, the dispersion of the present invention has high biosafety, and is very useful in the above-mentioned applications, particularly from the viewpoint of safety required for pharmaceuticals and cosmetics.
In addition, the dispersion of the present invention is expected to be a dispersion having good refreshing feeling and elongation when applied to human skin and the like, and is a liquid base containing pigments and powders for pharmaceuticals and cosmetics. It can be expected to be used as a material and is very useful.

FIG. 1 shows the foundations of the pigments prepared in Examples 1 to 3 and Comparative Example 1 containing 10% by mass (Example 1, Example 2 and Comparative Example 1) and 15% by mass (Example 3). It is a figure showing appearance. FIG. 2 is a view showing the appearance of the pearl pigment-containing dispersions prepared in Examples 4, 5 and Comparative Example 2. FIG. 3 is a view showing the appearance of the dispersion liquid containing tricalcium phosphate prepared in Example 6 and Comparative Example 3. FIG. 4 is a diagram showing the appearance of the gold foil-containing dispersions prepared in Example 7, Example 8, and Comparative Example 4. FIG. 5 is a diagram showing observation results (photographs) of the O / W liquid foundation prepared in Example 9 and Comparative Example 5 by a polarizing microscope. FIG. 6 is a diagram showing the appearance of the O / W liquid foundation prepared in Example 9 and Comparative Example 5 one month after preparation.

The present invention provides a pigment comprising a surfactant, water, and a lipid peptide-type compound comprising at least one of the compounds represented by the following formulas (1) to (3) or a pharmaceutically usable salt thereof. Or a dispersion comprising a powder dispersant, a 1,2-alkanediol or 1,3-alkanediol, a fatty acid, at least one selected from the group consisting of pigments and powders, and optionally other additives. Liquid. The present invention is also directed to a pigment or powder dispersant comprising the lipid peptide type compound.
Hereinafter, each component will be described.

[Dispersant for pigment or powder: lipid peptide type compound]
As the lipid peptide type compound used as the pigment or powder dispersant of the present invention, a compound (lipid peptide) represented by the following formulas (1) to (3) or a pharmaceutically usable salt thereof (hydrophobic) Low-molecular-weight compound having a lipid portion as a site and a peptide portion as a hydrophilic portion).

In the above formula (1), R ¹ represents an aliphatic group having 9 to 23 carbon atoms, and preferably, R ¹ is a linear group having 11 to 23 carbon atoms which can have 0 to 2 unsaturated bonds. Desirably, it is an aliphatic group.
Specific examples of the lipid portion (acyl group) composed of a carbonyl group adjacent to R ¹ include a lauroyl group, a dodecylcarbonyl group, a myristoyl group, a tetradecylcarbonyl group, a palmitoyl group, a margaroyl group, an oleoyl group, and an elideyl group. A linoleoyl group, stearoyl group, vaccenoyl group, octadecylcarbonyl group, arachidoyl group, eicosylcarbonyl group, behenoyl group, ercanoyl group, docosylcarbonyl group, lignosyl group, nervonoyl group, etc. Lauroyl, myristoyl, palmitoyl, margaroyl, stearoyl, oleoyl, elideyl and behenoyl.

In the above formula (1), R ² contained in the peptide moiety represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms and having a branched chain having 1 or 2 carbon atoms.
The alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms means that the main chain has 1 to 4 carbon atoms and the branched chain having 1 or 2 carbon atoms. It means an alkyl group which may have, and specific examples thereof include a methyl group, an ethyl group, an n-propyl group, an i-propyl group, an n-butyl group, an i-butyl group, a sec-butyl group and a tert-butyl group. And the like.
R ² is preferably a hydrogen atom or an alkyl group having 1 to 3 carbon atoms which may have a branched chain having 1 carbon atom, and more preferably a hydrogen atom.
An alkyl group having 1 to 3 carbon atoms that may have a branched chain having 1 carbon atom refers to an alkyl group having 1 to 3 carbon atoms in the main chain and having a branched chain having 1 carbon atom. And specific examples thereof include a methyl group, an ethyl group, an n-propyl group, an i-propyl group, an i-butyl group or a sec-butyl group, and preferably a methyl group, an i-propyl group, It is an i-butyl group or a sec-butyl group.

In the above formula (1), ^{R 3} represents - _(CH 2) n-X group. In the above-mentioned — (CH ₂ ) n—X group, n represents a number of 1 to 4, and X represents an amino group, a guanidino group, a —CONH ₂ group, or a 5-membered cyclic group having 1 to 3 nitrogen atoms. Represents a group or a 6-membered cyclic group, or a fused heterocyclic group composed of a 5-membered ring and a 6-membered ring.
Representing the ^{R 3} - In _(CH 2) n-X group, X is preferably an amino group, a guanidino group, a carbamoyl group (-CONH ₂ group), a pyrrole group, an imidazole group, a pyrazole group or indole group, more Preferably it is an imidazole group. In the above-mentioned — (CH ₂ ) nX group, n is preferably 1 or 2, and more preferably 1.
Accordingly, the - _(CH 2) n- group is preferably an aminomethyl group, 2-aminoethyl group, 3-aminopropyl group, 4-aminobutyl group, a carbamoylmethyl group, 2-carbamoyl-ethyl group, 3- carbamoyl Represents a butyl group, a 2-guanidinoethyl group, a 3-guanidinobutyl group, a pyrrolemethyl group, a 4-imidazolemethyl group, a pyrazolemethyl group, or a 3-indolemethyl group, and more preferably a 4-aminobutyl group or a carbamoylmethyl group. , 2-carbamoylethyl, 3-guanidinobutyl, 4-imidazolemethyl or 3-indolemethyl, more preferably 4-imidazolemethyl.

  Among the compounds represented by the above formula (1), a lipid peptide particularly suitable as a lipid peptide-type compound is a compound formed from the following lipid part and peptide part (amino acid assembly part). The abbreviations of amino acids include alanine (Ala), asparagine (Asn), glutamine (Gln), glycine (Gly), histidine (His), isolecin (Ile), leucine (Leu), lysine (Lys), and tryptophan (Trp). ) And valine (Val). : Lauroyl-Gly-His, Lauroyl-Gly-Gln, Lauroyl-Gly-Asn, Lauroyl-Gly-Trp, Lauroyl-Gly-Lys, Lauroyl-Ala-His, Lauroyl-Ala-Gln, Lauroyl-Ala-Asn, Lauroyl -Ala-Trp, Lauroyl-Ala-Lys; Myristoyl-Gly-His, Myristoyl-Gly-Gln, Myristoyl-Gly-Asn, Myristoyl-Gly-Trp, Myristoyl-Gly-Lys, Myristoyl-Ala-His, Myristoyl-Ala -Gln, myristoyl-Ala-Asn, myristoyl-Ala-Trp, myristoyl-Ala-Lys; palmitoyl-Gly-His, palmitoyl-Gly-Gln, palmitoyl-Gly-A n, Palmitoyl-Gly-Trp, Palmitoyl-Gly-Lys, Palmitoyl-Ala-His, Palmitoyl-Ala-Gln, Palmitoyl-Ala-Asn, Palmitoyl-Ala-Trp, Palmitoyl-Ala-Lys; Stearoyl-Gly-His Stearoyl-Gly-Gln, Stearoyl-Gly-Asn, Stearoyl-Gly-Trp, Stearoyl-Gly-Lys, Stearoyl-Ala-His, Stearoyl-Ala-Gln, Stearoyl-Ala-Asn, Stearoyl-Ala-Trp, Stearoyl- Ala-Lys.

  Most preferred are lauroyl-Gly-His, lauroyl-Ala-His-myristoyl-Gly-His, myristoyl-Ala-His; palmitoyl-Gly-His, palmitoyl-Ala-His; stearoyl-Gly-His, stearoyl-Ala. -His.

In the above formula (2), R ⁴ represents an aliphatic group having 9 to 23 carbon atoms, and preferred specific examples include the same groups as those defined for R ¹ above.
In the above formula (2), R ^{5 to} R ⁷ each independently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, which may have a branched chain having 1 or 2 carbon atoms, or-( CH ₂ ) nX, and at least one of R ^{5 to} R ⁷ represents a — (CH ₂ ) nX group. n represents a number of 1 to 4, and X represents an amino group, a guanidino group, a -CONH ₂ group, or a 5- or 6-membered cyclic group having 1 to 3 nitrogen atoms, or a 5-membered ring. And a fused heterocyclic group composed of a 6-membered ring. Here, preferred specific examples of R ^{5 to} R ⁷ include the same groups as defined for R ² and R ³ above.

  In the compound represented by the above formula (2), a preferred lipid peptide is a compound formed from the following lipid part and peptide part (amino acid assembly part). For example, lauroyl-Gly-Gly-His, lauroyl-Gly-Gly-Gln, lauroyl-Gly-Gly-Asn, lauroyl-Gly-Gly-Trp, lauroyl-Gly-Gly-Lys, lauroyl-Gly-Aly-His, Lauroyl-Gly-Ala-Gln, Lauroyl-Gly-Ala-Asn, Lauroyl-Gly-Ala-Trp, Lauroyl-Gly-Ala-Lys, Lauroyl-Ala-Gly-His, Lauroyl-Ala-Gly-Gln, Lauroyl- Ala-Gly-Asn, Lauroyl-Ala-Gly-Trp, Lauroyl-Ala-Gly-Lys, Lauroyl-Gly-His-Gly, Lauroyl-His-Gly-Gly, Myristoyl-Gly-Gly-His, Myristo Le-Gly-Gly-Gln, Myristoyl-Gly-Gly-Asn, Myristoyl-Gly-Gly-Trp, Myristoyl-Gly-Gly-Lys, Myristoyl-Gly-Ala-His, Myristoyl-Gly-Ala-Gln, Myristoyl- Gly-Ala-Asn, Myristoyl-Gly-Ala-Trp, Myristoyl-Gly-Ala-Lys, Myristoyl-Ala-Gly-His, Myristoyl-Ala-Gly-Gln, Myristoyl-Ala-Gly-Asn, Myristoyl-Ala- Gly-Trp, myristoyl-Ala-Gly-Lys, myristoyl-Gly-His-Gly, myristoyl-His-Gly-Gly, palmitoyl-Gly-Gly-His, palmitoyl-Gly-Gly Gln, Palmitoyl-Gly-Gly-Asn, Palmitoyl-Gly-Gly-Trp, Palmitoyl-Gly-Gly-Lys, Palmitoyl-Gly-Ala-His, Palmitoyl-Gly-Ala-Gln, Palmitoyl-Gly-Ala-Aly-Ala Palmitoyl-Gly-Ala-Trp, Palmitoyl-Gly-Ala-Lys, Palmitoyl-Ala-Gly-His, Palmitoyl-Ala-Gly-Gln, Palmitoyl-Ala-Gly-Asn, Palmitoyl-Ala-Gly-Trp, Palmitoyl Ala-Gly-Lys, Palmitoyl-Gly-His-Gly, Palmitoyl-His-Gly-Gly, Stearoyl-Gly-Gly-His, Stearoyl-Gly-Gly-Gln, Stearoyl -Gly-Gly-Asn, stearoyl-Gly-Gly-Trp, stearoyl-Gly-Gly-Lys, stearoyl-Gly-Ala-His, stearoyl-Gly-Ala-Gln, stearoyl-Gly-Ala-Asn, stearoyl-Gly. -Ala-Trp, stearoyl-Gly-Ala-Lys, stearoyl-Ala-Gly-His, stearoyl-Ala-Gly-Gln, stearoyl-Ala-Gly-Asn, stearoyl-Ala-Gly-Trp, stearoyl-Ala-Gly. -Lys, stearoyl-Gly-His-Gly, stearoyl-His-Gly-Gly.

  Among these, lauroyl-Gly-Gly-His, myristoyl-Gly-Gly-His, palmitoyl-Gly-Gly-His, palmitoyl-Gly-His-Gly, palmitoyl-His-Gly-Gly, stearoyl are most preferable. -Gly-Gly-His.

In the above formula (3), R ⁸ represents an aliphatic group having 9 to 23 carbon atoms, and specific preferred examples thereof include the same groups as defined for R ¹ above.
In the above formula (3), R ^{9 to} R ¹² each independently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, which may have a branched chain having 1 or 2 carbon atoms, or-( CH ₂ ) nX, and at least one of R ^{9 to} R ¹² represents a — (CH ₂ ) nX group. n represents a number of 1 to 4, and X represents an amino group, a guanidino group, a -CONH ₂ group, or a 5- or 6-membered cyclic group having 1 to 3 nitrogen atoms, or a 5-membered ring. And a fused heterocyclic group composed of a 6-membered ring. Here, preferred specific examples of R ^{9 to} R ¹² include the same groups as defined for R ² and R ³ above.

  Therefore, in the compound represented by the above formula (3), preferred lipid peptide-type compounds, particularly preferred lipid peptides include lauroyl-Gly-Gly-Gly-His, myristoyl-Gly-Gly-Gly-His, and palmitoyl. -Gly-Gly-Gly-His, palmitoyl-Gly-Gly-His-Gly, palmitoyl-Gly-His-Gly-Gly, palmitoyl-His-Gly-Gly-Gly, stearoyl-Gly-Gly-Gly-Gly-His and the like. No.

In the present invention, the compounding amount of the lipid peptide type compound as a pigment or powder dispersant is, for example, 0.01% by mass to 1% by mass, or 0.01% by mass with respect to the total mass of the obtained dispersion. The content is at least 1% by mass, preferably 0.05% by mass to 0.5% by mass, more preferably 0.05% by mass to 0.3% by mass, for example, 0.05% by mass to 0.2% by mass.
The lipid peptide compound used in the present invention comprises at least one of the compounds (lipid peptides) represented by the above formulas (1) to (3) or pharmaceutically usable salts thereof, These compounds can be used alone or in combination of two or more as a powder dispersant.

[Surfactant]
As the surfactant used in the dispersion of the present invention, a compound having a hydrophilic part and a hydrophobic part in the molecule, and the hydrophilic part having a betaine structure (hereinafter, also referred to as a betaine compound), ethylene glycol alkyl ether, Polyglycerin fatty acid ester or polyoxyethylene polyoxypropylene alkyl ether can be suitably used.

Examples of the above-mentioned betaine compounds include N-alkyl-N, N-dimethylamino acid betaine such as lauryl dimethylaminoacetic acid betaine (lauryl betaine); and fatty acid amide alkyl-N such as cocamidopropyl betaine and lauramide propyl betaine. , N-dimethylamino acid betaine; imidazoline betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkylsulfobetaines such as laurylhydroxysulfobetaine and alkyldimethyltaurine; sulfated betaines such as alkyldimethylaminoethanol sulfate; alkyldimethylaminoethanol A known betaine-based compound as an amphoteric surfactant such as a phosphoric acid type betaine such as a phosphate ester can be used.
Examples of the betaine-based compounds include phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, phosphatidylglycerol, diphosphatidylglycerol (cardiolipin), and glycerophospholipids such as phosphatidic acid; lysophosphatidylcholine (lysolecithinamine) Lysoglycerophospholipids such as serine, lysophosphatidylinositol, lysophosphatidylglycerol, and lysophosphatidic acid; sphingolipids such as sphingomyelin; and hydrogenated products thereof. These phospholipids may be derived from animals and plants such as soybean and egg yolk, and may be synthesized by a chemical or enzymatic method.
Among the above betaine compounds, preferably, lauryl dimethylaminoacetate betaine, lauric amide propyl betaine, lauryl hydroxysulfobetaine, stearyl betaine, lysophosphatidylcholine (lysolecithin), lysophosphatidylethanolamine, lysophosphatidylserine, lysophosphatidylinositol, lysophosphitol Examples thereof include phosphatidylglycerol and lysophosphatidic acid, and more preferably lysophosphatidylcholine (lysolecithin).

  Examples of the ethylene glycol alkyl ether include polyoxyethylene alkyl ether, polyoxyethylene lauryl ether, polyoxyethylene palmitoyl ether, polyoxyethylene stearyl ether, and the like. Commercially available ethylene glycol alkyl ethers can also be used. Examples of such products include, among the Emulgen (registered trademark) series and Emanon (registered trademark) series of Kao Corporation, Emulgen 102KG, Emulgen 103, and Emulgen 104P. , Emulgen 105, Emulgen 106, Emulgen 108, Emulgen 109P, Emulgen 120, Emulgen 123P, Emulgen 130K, Emulgen 147, Emulgen 150, Emulgen 210P, Emulgen 220, Emulgen 306P, Emulgen 320P, Emulgen 350, Emulgen 404, Emulgen 408, Emulgen 409PV, Emulgen 420, Emulgen 430, Emulgen 705, Emulgen 707, Emulgen 709, Emulgen 1108, Emulgen 1118S-70, Emulgen 1135S-70, Emulgen 1150S-60, Emulgen 4085, Emulgen 2020G-HA, Emulgen 2025G, Emanon 1112, Emanor 3199V, Emanon 3299V, Emanon 3299RV, include the Emanon 4110. More preferably, emulgen 103, emulgen 104P, emulgen 105, emulgen 106, emulgen 108, emulgen 109P, emulgen 210P, emulgen 306P, emulgen 320P, emulgen 404, emulgen 408, emulgen 409PV, emulgen 420, emulgen 705 of Kao Corporation , Emulgen 707, Emulgen 709, Emulgen 1108, Emulgen 2020G-HA, Emanon 1112, and Emanone 4110. More preferably, Kao Corporation's Emulgen 104P, Emulgen 105, Emulgen 106, Emulgen 108, Emulgen 210P, Emulgen 306P, Emulgen 408, Emulgen 409PV, Emulgen 705, Emulgen 707, Emulgen 709, Emulgen 1108, Emulgen 2020G-HA, Emanon 1112 and Emanon 4110. In addition, it can be appropriately selected from the NIKKOL (registered trademark) series of Nikko Chemicals Co., Ltd. For example, NIKKOL BT-5, NIKKOL BT-7, NIKKOL BT-9, NIKKOL BT-12, NIKKOL BL-2, NIKKOL BL-4.2, NIKKOL BL-9EX, and most preferably NIKOL are BLKOL. 4.2.

  Examples of the polyglycerin fatty acid ester include glyceryl stearate, glyceryl isostearate, glyceryl palmitate, glyceryl myristate, glyceryl oleate, glyceryl coconut oil, glycerin mono-cottonseed oil, glyceryl monoerucate, glyceryl sesquioleate, α, α Glycerin fatty acid partial esters such as glycerin pyroglutamate oleate and glyceryl monostearate; polyglyceryl-2, 3, 4, 5, 6, 8, and 10 and polyglyceryl distearate; 6, 10; polyglyceryl-2 tristearate, polyglyceryl-10 decasterate, polyglyceryl-2 isostearate, 3, 4, 5, 5, 6, 8, 10, diisostearate Glyceryl-2 (diglyceryl diisostearate), 3, and 10 (decaglyceryl diisostearate), polyglyceryl-2 triisostearate, polyglyceryl-2 tetraisostearate, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate, 3, 4, 5, 6, 8, 10, polyglyceryl-6 dioleate, polyglyceryl-2 trioleate, polyglyceryl-10 decaoleate, and the like.

  Examples of polyoxyethylene polyoxypropylene alkyl ether include Kao Corporation's Emulgen (registered trademark) LS-106, Emulgen LS-110, Emulgen LS-114, Emulgen MS-110, and NIKKOL (Registered by Nikko Chemicals Corporation) (Trademark) PBC-31, NIKKOL PBC-33, NIKKOL PBC-34, NIKKOL PBC-41, NIKKOL PBC-44, NIKKOL PBN-4612, NIKKOL PBN-4620, NIKKOL PBN-4630. More preferred are Emulgen LS-106, Emulgen LS-110, Emulgen LS-114, and Emulgen MS-110. More preferably, Emulgen LS-106, Emulgen LS-110, and Emulgen MS-110 are mentioned.

Further, as the surfactant used in the present invention, those having an HLB (Hydrophil-Lipophile Balance) value of 8 to 20 can be suitably used. More preferably, the HLB value is 8 to 14.
Examples of such a surfactant include sorbitan isostearate, steareth-8, behenes-10, laureth-4, laureth-5, ceteth-7, oleth-8, PEG-8 glyceryl isostearate, choles-10, and isostearin. Acid PEG-10BG, PEG-30 glyceryl triisostearate, PEG-30 glyceryl triisostearate, PEG-30 glyceryl trioleate, PEG-30 triisostearate trimethylolpropane, PEG-30 laurate hydrogenated castor oil, PCA PEG-30 isostearate hydrogenated castor oil, octyldedec-10, PEG-12 dilaurate, sorbeth-40 tetraoleate, polyglyceryl-10 diisostearate (decaglyceryl diisostearate), diisos PEG-20 glyceryl acrylate, PEG-8 isostearate, PEG-10 glyceryl isostearate, PEG-60 triisostearate hydrogenated castor oil, PPG-2-decess-7, oleth-10, hydrogenated dimer linoles- 20, coconut fatty acid sorbitan, isosteares-10, steareth-11, PEG-30 trimyristate trimethylolpropane, PEG-40 isostearate hydrogenated castor oil, PEG-40 isostearate hydrogenated castor oil, PCA isostearate PEG-40 Hydrogenated castor oil, laureth-7, isocetes-10, cetes-10, PEG-10 isostearate, PEG-10 stearate, PEG-10 oleate, PEG-10 stearate glyceryl, oleth-12, decyltetradeceth -15, -15, PEG-16 dilaurate, PEG-30 hydrogenated castor oil, PEG-40 glyceryl triisostearate, PEG-40 trioleate, PEG-40 triisostearate trimethylolpropane, PEG-40 laurate water And castor oil and PEG-12 laurate.

In the present invention, the amount of the surfactant is, for example, 0.01% by mass to 2% by mass, or 0.01% by mass to 1% by mass, preferably 0% by mass, based on the total mass of the obtained dispersion. It is 0.01% to 0.5% by mass, more preferably 0.01% to 0.3% by mass, for example, 0.02% to 0.2% by mass.
The surfactant used in the present invention is at least one of the above surfactant groups, and these surfactants can be used alone or in combination of two or more.

[1,2-alkanediol or 1,3-alkanediol]
The 1,2-alkanediol or 1,3-alkanediol used in the dispersion of the present invention has a function of promoting the solubility of the pigment or the lipid peptide-type compound which is a dispersant for powder.
Specific examples of the 1,2-alkanediol include 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, and 1,2-decanediol. Preferably, 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol are used. More preferably, it is 1,2-pentanediol or 1,2-hexanediol.
Specific examples of the 1,3-alkanediol include 1,3-propanediol, 2-methyl-1,3-propanediol, 1,3-butanediol, 3-methyl-1,3-butanediol, , 3-pentanediol, 1,3-hexanediol, 2-ethyl-1,3-hexanediol, 2-ethyl-1,3-octanediol, 1,3-decanediol and the like. Preferred are 1,3-butanediol, 1,3-pentanediol, 1,3-hexanediol, 2-ethyl-1,3-hexanediol, and 2-ethyl-1,3-octanediol. More preferred are 1,3-butanediol, 2-ethyl-1,3-hexanediol, and 2-ethyl-1,3-octanediol.
These 1,2-alkanediols or 1,3-alkanediols can be used alone or in combination of two or more.

  In the present invention, the blending amount of the 1,2-alkanediol or 1,3-alkanediol is, for example, 0.001% by mass to 15% by mass, preferably 0.1% by mass, based on the total mass of the obtained dispersion. 005 mass% to 15 mass%, more preferably 0.01 mass% to 15 mass%, for example, 0.01 mass% to 12 mass%.

[fatty acid]
The fatty acid used in the dispersion of the present invention is preferably at least one selected from the group consisting of saturated fatty acids and unsaturated fatty acids having 10 to 20 carbon atoms and salts of these fatty acids. , Undecanoic acid, lauric acid, tridecanoic acid, myristic acid, pentadecanoic acid, palmitic acid, margaric acid and stearic acid. More preferred are capric acid, lauric acid, myristic acid, palmitic acid, and stearic acid, with stearic acid being preferred.
In the present invention, the amount of the fatty acid used is, for example, from 0.001% by mass to 1% by mass, preferably from 0.001% by mass to 0.1% by mass, based on the total mass of the obtained dispersion. Preferably it is 0.005% by mass to 0.05% by mass.
The fatty acid used in the present invention is at least one selected from the above fatty acid group, and these fatty acids can be used alone or in combination of two or more.

[Pigment or powder]
The pigment or powder to be blended in the dispersion of the present invention is not particularly limited.
For example, pigments include inorganic white pigments such as titanium dioxide and zinc oxide; inorganic red pigments such as red iron oxide (iron oxide) and iron titanate; inorganic brown pigments such as γ-iron oxide; yellow iron oxide; Inorganic black pigments such as black iron oxide and low titanium oxide; inorganic purple pigments such as mango violet and cobalt violet; inorganic green pigments such as chromium oxide, chromium hydroxide and cobalt titanate; Inorganic blue pigments such as ultramarine blue, navy blue and the like; pearl pigments such as titanium oxide coated mica, titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, fish scale foil; talc, sericite, mica , Kaolin, calcium carbonate, magnesium carbonate, silicic anhydride, barium sulfate, aluminum hydroxide, etc. Fee; aluminum powder, copper powder, metal powder pigments such as gold; surface treated inorganic and metallic powder pigments; zirconium, organic pigments such as barium or aluminum lake; surface treatment organic pigments. Among these pigments, hydrophilic pigments are more preferred.
Examples of powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, biotite, biotite, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, and silica. Barium acid, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate such as tricalcium phosphate, fluorine apatite, hydroxyapatite, ceramic powder, bentonite, Smectite, clay, mud, metal soap (eg, zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide, ultramarine, navy blue, carbon black, Titanium oxide, fine particles and ultrafine titanium oxide, zinc oxide, fine particles and ultrafine zinc oxide, alumina, silica, fumed silica (ultrafine silica), titanium mica, fish scale foil, boron nitride, photochromic pigment, synthetic fluorine Inorganic powders of various sizes and shapes such as phlogopite, fine particle composite powder, gold, silver, platinum, aluminum, etc., and silicone or other silane or titanium cups such as hydrogen silicone and cyclic hydrogen silicone Inorganic powders such as powders that have been hydrophobized or hydrophilized by treatment with various surface treatment agents such as ring agents; starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, styrene and acrylic acid Copolymer resin powder, polyester powder, benzoguanamine resin powder Organic powders and surface-treated powders of various sizes and shapes, such as polyethylene terephthalate / polymethyl methacrylate laminate powder, polyethylene terephthalate / aluminum / epoxy laminate powder, urethane powder, silicone powder, Teflon (registered trademark) powder, etc. And an organic-inorganic composite powder are preferred.
In the present invention, the content of the pigment or powder may be, for example, 25% by mass or less, preferably 20% by mass or less, based on the total mass of the dispersion. The lower limit of the amount of the pigment or powder is not particularly limited, but is, for example, about 0.001% by mass.
The pigment or powder used in the present invention is at least one of the above-described pigment group and powder group, and these pigments or powder can be used alone or in combination of two or more.

[Polyhydric alcohol]
The dispersion of the present invention may further contain a polyhydric alcohol. The polyhydric alcohol is a polyhydric alcohol different from the aforementioned 1,2-alkanediol or 1,3-alkanediol, and specific examples thereof include glycerin, propylene glycol, and polyethylene glycol. As the above-mentioned polyethylene glycol, for example, those having an average molecular weight of 1,000 to 4,000 can be suitably used.
In the present invention, when a polyhydric alcohol is contained, the compounding amount is, for example, 1% by mass to 60% by mass, preferably 10% by mass to 30% by mass based on the total mass of the obtained dispersion. it can.

[Other additives]
The dispersion of the present invention may contain, if necessary, additives for cosmetics, quasi-drugs, and additives that can be used as pharmaceutical additives. Examples of additional components such as physiologically active substances and functional substances to be added to cosmetics, quasi-drugs or skin external preparations such as medicines include, for example, oily bases, humectants, feel improvers, surfactants other than those described above, Polymers, thickeners / gelling agents, solvents, antioxidants, reducing agents, oxidizing agents, preservatives, antibacterial agents, bactericides, chelating agents, pH adjusters, acids, alkalis, inorganic salts, ultraviolet absorbers, whitening Preparations, vitamins and their derivatives, hair growth agents, blood circulation promoters, stimulants, hormones, anti-wrinkle agents, anti-aging agents, tightening agents, cooling sensation agents, warming agents, wound healing promoters, stimulants , Analgesics, cell activators, plant / animal / microbial extracts, antipruritics, exfoliants / dissolving agents, antiperspirants, refreshing agents, astringents, enzymes, nucleic acids, fragrances, pigments, coloring agents, dyes, anti-inflammatory agents, Anti-inflammatory, anti-asthma, anti-chronic obstructive pulmonary disease, anti-allergy, immunomodulator, anti-inflammatory Infectious diseases agents and antifungal agents.
The amount of these other additives may vary depending on the type thereof, but is, for example, about 0.001 to 20% by mass, or about 0.01 to 10% by mass based on the total mass of the dispersion. can do.

  Examples of the oil base include higher (polyhydric) alcohols such as oleyl alcohol, jojoba alcohol, chimyl alcohol, seraky alcohol, butyl alcohol, hexyldecanol, isostearyl alcohol, 2-octyldodecanol, and dimer diol; benzyl alcohol and the like. Aralkyl alcohols and derivatives thereof: isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, palmitooleic acid, oleic acid, linoleic acid, linoleic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexadecanoic acid, Anteisohenicosanoic acid, long-chain branched fatty acid, dimer acid, hydrogenated dimer acid, etc .; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α-olefin Gomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene, petrolatum, hydrocarbons such as solid paraffin; candelilla wax, carnauba wax, rice wax, wood wax, beeswax, montan wax, ozokerite, ceresin Waxes such as paraffin wax, microcrystalline wax, petrolatum, Fischer-Tropsch wax, polyethylene wax, ethylene-propylene copolymer; coconut oil, palm oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado oil, sesame oil, Tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, kukuinut oil, rosehip oil, meadowfoam oil, persic oil, tea tree oil, peppermint oil , Corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, cocoa butter, shea butter, hydrogenated coconut oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba Vegetable oils such as oil, grape seed oil, apricot oil (almond oil), camellia oil; animal oils such as beef tallow, milk fat, horse fat, egg yolk oil, mink oil, turtle oil; whale wax, lanolin, orange wrap Animal waxes such as fee oil; liquid lanolin, reduced lanolin, adsorbed purified lanolin, lanolin acetate, lanolin acetate liquid, hydroxylanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin alcohol acetate, acetic acid ( Lanolins such as cetyl / lanolyl) ester; cholesterol, dihydrocholesterol, and lanolin Sterols such as terol, dihydrolanosterol, phytosterol, and cholic acid; sapogenins; saponins; cholesteryl acetate, cholesteryl nonanoate, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, di-cholesteryl N-lauroyl-L-glutamate (cholesteryl / Behenyl / octyldodecyl), N-lauroyl-L-glutamate di (cholesteryl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / octyl) Dodecyl), acyl sarcosine alkyl esters such as N-lauroyl sarcosine isopropyl, cholesteryl 12-hydroxystearate, macadamia nut fats and oils Sterol esters such as cholesteryl acid cholesteryl, macadamia nut oil fatty acid phytosteryl, phytosteryl isostearate, soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long-chain branched fatty acid cholesteryl, long-chain α-hydroxy fatty acid cholesteryl; phospholipid-cholesterol complex, phospholipid Lipid complexes such as phytosterol complexes; octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl palmitate, octyldodecyl palmitate, cetyl octanoate, hexyldecyl octanoate, isotridecyl isononanoate, isononyl isononanoate Octyl isononanoate, isotridecyl isononanoate, isodecyl neopentanoate, isotridecyl neopentanoate, Isostearyl oppentanate, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, octyldodecyl lanolin fatty acid, hexyldecyl dimethyloctanoate, octyldodecyl erucate, hydrogenated castor oil isostearate, ethyl oleate, Avocado oil fatty acid ethyl, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, isopropyl lanolin fatty acid, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyl octyl sebacate, diisobutyl adipate, Monoalcohol carboxylic esters such as dioctyl succinate and triethyl citrate; Oxyacid esters such as hydrogenated, diisostearyl malate, hydrogenated castor oil monoisostearate; glyceryl trioctanoate (glyceryl tri-2-ethylhexanoate), glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, Glyceryl (caprylic / capric acid), tri (caprylic / capric / myristic / stearic) glyceryl, hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl eicosan diacid behenate, Trimethylolpropane trioctanoate, trimethylolpropane triisostearate, neopentyl glycol dioctanoate, neopentyl glycol dicaprate, 2-butyl-2-ethyl-1,2 dioctanoate, 3-propanediol, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenated rosin pentaerythrityl, ditrimethylolpropane triethylhexanoate, ditrimethylolpropane (isostearate / sebacate), pentaerythrityl triethylhexanoate, ( (Hydroxystearic acid / stearic acid / rosinic acid) dipentaerythrityl, diglyceryl diisostearate, polyglyceryl tetraisostearate, polyglyceryl-10 nonisostearate, deca (erucic acid / isostearic acid / ricinoleic acid) polyglyceryl-8, (hexyldecanoic acid / sebacic acid) ) Diglyceryl oligoester, glycol distearate (ethylene glycol distearate), dineopentanoic acid 3- Polyhydric alcohol fatty acid esters such as tyl-1,5-pentanediol and 2,4-diethyl-1,5-pentanediol dinepentanoate; diisopropyl dimer dilinoleate, diisostearyl dimer dilinoleate, dimer dilinoleic acid Di (isostearyl / phytosteryl), dimer dilinoleic acid (phytosteryl / behenyl), dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl), dimer dilinoleyl dimer dilinoleate, dimer dilinoleyl diisostearate , Dimer dilinoleyl hydrogenated rosin condensate, dimer dilinoleic acid-hardened castor oil, dimer acid or dimer diol derivatives such as hydroxyalkyl dimer dilinoleyl ether; coconut oil fatty acid monoethano Luamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (Partamide MEA), fatty acid alkanolamides such as palmitic acid diethanolamide (partamide DEA), coconut fatty acid methylethanolamide (cocamidomethyl MEA); dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclo Methicon (cyclic dimethylsiloxane, decamethylcyclopentasiloxane (also simply cyclopentasiloxane)), phenyltrimethicone, diphenyl Dimethicone, phenyldimethicone, stearoxypropyldimethylamine, (aminoethylaminopropylmethicone / dimethicone) copolymer, dimethiconol, dimethiconol crosspolymer, silicone resin, silicone rubber, amino-modified silicone such as aminopropyl dimethicone and amodimethicone, cation-modified silicone, Polyether modified silicone such as dimethicone copolyol, polyglycerin modified silicone, sugar modified silicone, carboxylic acid modified silicone, phosphoric acid modified silicone, sulfuric acid modified silicone, alkyl modified silicone, fatty acid modified silicone, alkyl ether modified silicone, amino acid modified silicone, Peptide-modified silicone, fluorine-modified silicone, cation-modified and polyether-modified silicone, Preferred are silicones such as modified and polyether-modified silicones, alkyl-modified and polyether-modified silicones, polysiloxane / oxyalkylene copolymers; and fluorine-based oils such as perfluorodecane, perfluorooctane, and perfluoropolyether. It is listed as.

  Examples of humectants and feel improvers include glycerin, trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, dipropylene glycol, polypropylene glycol, and polyols such as ethylene glycol / propylene glycol copolymer. The polymer; glycol alkyl ethers such as diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether; (eicosane diacid / tetradecane diacid) polyglyceryl-10, tetradecane di Water-soluble esters such as polyglyceryl-10 acid; sorbitol, xylitol, erythritol, mannitol Sugar, maltitol and the like; glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrin ( α-, β-, γ-cyclodextrin and modified cyclodextrins such as maltosylation and hydroxyalkylation), β-glucan, chitin, chitosan, heparin and derivatives, pectin, arabinogalactan, dextrin, dextran, glycogen, Saccharides such as ethyl glucoside, glucosylethyl methacrylate polymer or copolymer, and derivatives thereof; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin Sulfuric acid, caronine sulfate, keratosulfate, dermatan sulfate; white jellyfish extract, white jellyfish polysaccharide; fucoidan; tuberose polysaccharide or naturally occurring polysaccharide; organic acids such as citric acid, tartaric acid, lactic acid and salts thereof; urea and its derivatives; -Pyrrolidone-5-carboxylic acid and salts thereof such as sodium; betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamic acid, glutamine, asparagine , Aspartic acid, cysteine, cysteine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine and other amino acids and their salts; collagen, collagen derived from fish, atelocollagen, gelatin Elastin, Collagen Degradation Peptide, Hydrolyzed Collagen, Hydroxypropylammonium Chloride Hydrolyzed Collagen, Elastin Degradation Peptide, Keratin Decomposition Peptide, Hydrolyzed Keratin, Conchiolin Degradation Peptide, Hydrolyzed Conchiolin, Silk Proteolysis Peptide, Hydrolyzed Silk, Lauroyl Hydrolysis Protein peptides such as silk sodium, soybean proteolytic peptide, wheat proteolytic peptide, hydrolyzed wheat protein, casein degradable peptide, acylated peptide and derivatives thereof; acylated peptides such as palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide Peptides; silylated peptides; lactic acid bacteria culture, yeast extract, shell membrane protein, bovine submandibular gland mucin, hypotaurine, sesame lignan glycoside, glutathione, Albumin, whey; choline chloride, phosphorylcholine; placental extract, aerastin, collagen, aloe extract, hamamelis water, loofah water, chamomile extract, licorice extract, comfrey extract, silk extract, lyophila extract, yarrow extract, eucalyptus extract , Ceramides such as natural ceramides (types 1, 2, 3, 4, 5, 6), hydroxyceramides, pseudo-ceramides, glycosphingolipids, ceramides and sugar ceramide-containing extracts. Preferred are mentioned.

Preferred examples of the surfactant include an anionic surfactant, a nonionic surfactant, a cationic surfactant, an amphoteric surfactant, and a polymer surfactant. Preferred examples of the surfactant include, as anionic surfactants, fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfate salts such as sodium lauryl sulfate, triethanolamine lauryl sulfate and ammonium lauryl sulfate; Polyoxyethylene alkyl sulfates such as sodium laureth sulfate and triethanolamine laureth sulfate; cocoyl methyl taurine sodium, cocoyl methyl taurine potassium, lauroyl methyl taurine sodium, myristoyl methyl taurine sodium, lauroyl methyl alanine sodium, lauroyl sarcosine sodium, lauroyl sarcosine tri Acyl N-methyl amino acid salts such as ethanolamine and sodium lauroylglutamate methylalanine sodium; cocoyl Acyl amino acid salts such as sodium rutamate, cocoyl glutamate triethanolamine, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, palmitoyl aspartate ditriethanolamine, cocoyl alanine triethanolamine; polyoxyethylene alkyl ethers such as sodium laureth acetate Acetate; succinate such as sodium lauroyl monoethanolamide succinate; fatty acid alkanolamide ether carboxylate; acyl lactate; polyoxyethylene fatty amine sulfate; fatty acid alkanolamide sulfate; hydrogenated coconut oil sodium glycerin sulfate Fatty acid glyceride sulfate; alkylbenzene polyoxyethylene sulfate; α-olefin Olefin sulfonates such as sodium disulfonic acid; alkyl sodium sulfosuccinates such as sodium lauryl sulfosuccinate and dioctyl sodium sulfosuccinate; sodium laureth sulfosuccinate; sodium monolauroyl monoethanolamide polyoxyethylene sulfosuccinate; lauryl polypropylene glycol sulfosuccinate Alkyl ether sulfosuccinates such as sodium; alkylbenzene sulfonates such as sodium tetradecylbenzene sulfonate and triethanolamine tetradecylbenzene sulfonate; alkyl naphthalene sulfonates; alkane sulfonates; α-sulfofatty acid methyl ester salts; Acyl isethionate; alkyl glycidyl ether sulfonate; alkyl sulfoacetate; laureth Alkyl ether phosphate salts such as sodium phosphate, sodium dilaurate phosphate, sodium trilaurate phosphate and sodium monooleate phosphate; alkyl phosphate ester salts such as potassium lauryl phosphate; sodium caseinate; alkyl aryl ether phosphate; fatty acid amide Ether phosphates; phospholipids such as phosphatidylglycerol, phosphatidylinositol, and phosphatidic acid; silicone-based anionic surfactants such as carboxylic acid-modified silicone, phosphoric acid-modified silicone, and sulfuric acid-modified silicone; nonionic surfactants Examples include laureth (polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), steareth (polyoxyethylene stearyl ether), and behenes (polyoxyethylene). Polyoxyethylene alkyl ethers having various polyoxyethylene addition numbers, such as poly (ethylene behenyl ether) s, isosteares (polyoxyethylene isostearyl ether), and octyldodeces (polyoxyethylene octyldodecyl ether); polyoxyethylene alkylphenyl Ether: Polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearate diester , Polyoxyethylene hydrogenated castor oil Castor oil and hydrogenated castor oil derivatives such as maleic acid; polyoxyethylene phytosterol; polyoxyethylene cholesterol Polyoxyethylene cholestanol; polyoxyethylene lanolin; polyoxyethylene reduced lanolin; polyoxyethylene / polyoxypropylene cetyl ether, polyoxyethylene / polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene / polyoxypropylene monobutyl ether (Polyoxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene / polyoxypropylene glycerin ether, etc., polyoxyethylene / polyoxypropylene alkyl ether; polyoxyethylene / polyoxypropylene glycol; PPG-9 diglyceryl, etc.) Poly) glycerin polyoxypropylene glycol; glyceryl stearate, glyceryl isostearate, glyceryl palmitate, millimeter Glycerin fatty acid partial esters such as glyceryl citrate, glyceryl oleate, glyceryl coconut oil, glycerin mono-cottonseed oil, glycerin monoerucate, glycerin sesquioleate, glycerin α, α'-oleate pyroglutamate, glycerin monostearate and malic acid And polyglyceryl-2, 3, 4, 5, 6, 8, 10, distearate polyglyceryl-6, tristearate polyglyceryl-2, decastearate polyglyceryl-10, isostearin Polyglyceryl-2, 3, 4, 5, 6, 8, 10, polyglyceryl-2 diisostearate (diglyceryl diisostearate), 3, 10, triglyceryl-2 triisostearate, tetraisostearin Polyglyceryl-2, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate, same 3,4,5,6,8,10, polyglyceryl-6 dioleate, polyglyceryl-2 trioleate, decaoleic acid Polyglycerin fatty acid ester such as polyglyceryl-10; ethylene glycol monofatty acid ester such as ethylene glycol monostearate; propylene glycol monofatty acid ester such as propylene glycol monostearate; pentaerythritol partial fatty acid ester; sorbitol partial fatty acid ester; Fatty acid ester; maltitol ether; sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan Sorbitan fatty acid esters such as monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate; sucrose fatty acid esters, methyl glucoside fatty acid esters, undecylene Partial esters of sugar derivatives such as trehalose acid; alkyl glucosides such as caprylyl glucoside; alkyl polyglycosides; lanolin alcohol; reduced lanolin; polyoxyethylene distearate, polyethylene glycol diisostearate, polyoxyethylene monooleate, poly Polyoxyethylene fatty acid mono and diesters such as oxyethylene dioleate; polyoxyethylene / propylene glycol fatty acid esters; Polyoxyethylene glycerin fatty acid esters such as polyoxyethylene monooleate such as xylethylene glycerin monostearate, polyoxyethylene glycerin monoisostearate, and polyoxyethylene glycerin triisostearate; polyoxyethylene sorbitan monooleate, poly Polyoxyethylene sorbitan fatty acid esters such as oxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan tetraoleate; polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol Polyoxyethylene sorbitol such as pentaoleate and polyoxyethylene sorbitol monostearate Fatty acid esters; polyoxyethylene methyl glucoside fatty acid esters; polyoxyethylene alkyl ether fatty acid esters; polyoxyethylene animal and vegetable oils such as polyoxyethylene sorbitol beeswax; isostearyl glyceryl ether, chimyl alcohol, seralkyl alcohol, batyl alcohol, etc. Alkyl glyceryl ethers; polyhydric alcohol alkyl ethers; polyoxyethylene alkylamines; tetrapolyoxyethylene / tetrapolyoxypropylene-ethylenediamine condensates; natural surfactants such as saponins and sophorolipids; polyoxyethylene fatty acid amides; Coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (Lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide DEA), coconut oil fatty acid methylethanolamide ( Fatty acid alkanolamides such as cocamidomethyl MEA); alkyl dimethylamine oxides such as lauramine oxide, cocamine oxide, stearamine oxide, and behenamine oxide; alkyl ethoxy dimethyl amine oxides; polyoxyethylene alkyl mercaptans; Polyether-modified silicone, polysiloxane / oxyalkylene copolymer, polyglycerin-modified silicone, sugar-modified silicone, etc. Silicone-based nonionic surfactants; cationic surfactants include alkyltrimethylammonium chlorides such as behentrimonium chloride, stealtrimonium chloride, cetrimonium chloride, lauryltrimonium chloride; stearyltrimonium bromide Alkyltrimethylammonium bromide; dialkyldimethylammonium chlorides such as distearyldimonium chloride and dicocodimonium chloride; fatty acid amidoamines such as stearamidopropyldimethylamine and stearamidoethyldiethylamine and salts thereof; alkyl ethers such as stearoxypropyldimethylamine Amines and their salts or quaternary salts; ethyl sulfate long-chain branched fatty acid (12-31) aminopropylethyldimethylammonium, ethyl Fatty acid amide type quaternary ammonium salts such as lanolin acid fatty acid aminopropylethyldimethylammonium; polyoxyethylene alkylamine and its salts or quaternary salts; alkylamine salt; fatty acid amide guanidinium salt; alkyl ether amine monium salt; Alkylene glycol ammonium salts; benzalkonium salts; benzethonium salts; pyridinium salts such as cetylpyridinium chloride; imidazolinium salts; alkylisoquinolinium salts; dialkylmorphonium salts; Silicone cationic surfactant such as amino-modified silicone, cation-modified silicone, cation-modified and polyether-modified silicone, amino-modified and polyether-modified silicone Examples of the amphoteric surfactant; etc
N-alkyl-N, N-dimethylamino acid betaine such as lauryl betaine (lauryl dimethylaminoacetic acid betaine); fatty acid amide alkyl-N, N-dimethyl amino acid betaine such as cocamidopropyl betaine and lauramide propyl betaine; sodium cocoamphoacetate; Imidazoline-type betaines such as sodium lauroamphoacetate; alkylsulfobetaines such as alkyldimethyltaurine; sulfate-type betaines such as alkyldimethylaminoethanol sulfate; phosphate-type betaines such as alkyldimethylaminoethanol phosphate; phosphatidylcholine, phosphatidylethanolamine; Sphingolipids such as phosphatidylserine and sphingomyelin, lysolecithin, hydrogenated soybean phospholipids, partially hydrogenated soybean phospholipids, hydrogen Phospholipids such as egg yolk phospholipids, partially hydrogenated egg yolk phospholipids, and lecithin hydroxide; silicone-based amphoteric surfactants; polymer surfactants include polyvinyl alcohol, sodium alginate, starch derivatives, tragacanth gum, acrylic acid -Alkyl methacrylate copolymer; various silicone-based surfactants are preferred.

  Guar gum, locust bean gum, Queen seed, carrageenan, galactan, gum arabic, tara gum, tamarind, furceleran, karaya gum, troloi, chara gum, tragacanth gum, pectin, pectic acid and sodium Salts such as salts, salts such as alginic acid and sodium salt, mannan; starches such as rice, corn, potato, wheat, etc .; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salts, xanthan gum, pullulan, gellan gum, chitin , Chitosan, agar, gypsophila extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropyl Cellulose, hydroxypropylmethylcellulose, carboxymethylcellulose and salts thereof such as sodium, methylhydroxypropylcellulose, sodium cellulose sulfate, dialkyldimethylammonium sulfate, crystalline cellulose, cellulose powder and the like, and derivatives thereof; soluble starch, carboxymethyl starch, methyl Starch polymers such as hydroxypropyl starch and methyl starch; starch derivatives such as hydroxypropyltrimonium chloride starch; corn starch succinate aluminum; alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyridone (PVP), polyvinyl alcohol (PVA), vinyl pidridone vinyl al Copolymer, polyvinyl methyl ether; polyethylene glycol, polypropylene glycol, polyoxyethylene / polyoxypropylene copolymer; (methacryloyloxyethyl carboxybetaine / alkyl methacrylate) copolymer, (acrylates / stearyl acrylate / ethylamine methacrylate) Amphoteric methacrylate copolymers such as (oxide) copolymers; (dimethicone / vinyl dimethicone) crosspolymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP; Compound, maleic acid copolymer; vinylpyrrolidone / dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine; Polyesters, water-dispersible polyesters; polyacrylamides; polyacrylic acid ester copolymers such as polyethyl acrylate; carboxyvinyl polymers; polyacrylic acid and salts thereof such as sodium salts; acrylic acid / methacrylic acid ester copolymers; Acrylic acid / alkyl methacrylate copolymer; cationized cellulose such as polyquaternium-10, diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-7, acrylic acid / diallyldimethylammonium chloride copolymer such as polyquaternium-22 , Diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-39, acrylic acid / cationized methacrylate copolymer, acrylic acid / cationized methacrylic acid Acid amide copolymer, acrylic acid / methyl acrylate / methacrylamidopropyltrimethylammonium chloride copolymer such as polyquaternium-47, choline methacrylate chloride polymer; cationized oligosaccharide, cationized dextran, guar hydroxypropyltrimonium Cationic polysaccharides such as chloride; polyethyleneimine; cationic polymers; copolymers of 2-methacryloyloxyethyl phosphorylcholine such as polyquaternium-51 and copolymers with butyl methacrylate copolymer; acrylic resin emulsions, polyethyl acrylate Emulsions, polyacrylalkylester emulsions, polyvinyl acetate resin emulsions, polymer emulsions such as natural rubber latex and synthetic latex; nitrocellulose; And various copolymers; various silicones; various silicone-based copolymers such as acrylic-silicone graft copolymers; various fluorine-containing polymers; 12-hydroxystearic acid and salts thereof; dextrin palmitate and dextrin myristate Dextrin fatty acid esters such as; silicic anhydride, fumed silica (ultrafine silicic anhydride), aluminum magnesium silicate, sodium magnesium silicate, metal soap, metal dialkylphosphate, bentonite, hectorite, organically modified clay mineral, Sucrose fatty acid esters and fructooligosaccharide fatty acid esters are preferred. Among the above examples, cellulose and derivatives thereof, alginic acid and salts thereof, polyvinyl alcohol, hyaluronic acid and salts thereof, and collagen are preferable.

  Examples of the solvent include lower alcohols such as ethanol, 2-propanol (isopropyl alcohol), butanol and isobutyl alcohol; glycols such as propylene glycol, diethylene glycol, dipropylene glycol and isopentyl diol; diethylene glycol monoethyl ether (ethoxydiglycol). Glycol ethers such as ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether; ethylene glycol monoethyl ether Acetate, diethylene glycol mono Glycol ether esters such as tyl ether acetate and propylene glycol monoethyl ether acetate; glycol esters such as diethoxyethyl succinate and ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate, acetone, and acetic acid Preferred examples include ethyl, N-methylpyrrolidone and toluene.

  As antioxidants, tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and / or its derivatives; erythorbic acid and its derivatives; Sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfite; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, and cysteine hydrochloride are preferred It is listed as.

  Preferred examples of the reducing agent include thioglycolic acid, cysteine, and cysteamine.

  Preferred examples of the oxidizing agent include aqueous hydrogen peroxide, ammonium persulfate, sodium bromate, percarbonate and the like.

  Examples of preservatives, antibacterial agents, and bactericides include hydroxybenzoic acid such as methylparaben, ethylparaben, propylparaben, and butylparaben and salts or esters thereof; salicylic acid; sodium benzoate; phenoxyethanol; methylchloroisothiazolinone; Isothiazolinone derivatives such as linone; imidazolinium urea; dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides, quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzalkonium chloride, chloride Benzethonium, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, hinokitiol; phenol, isopropylphenol, cresol, thiocyanate Lumpur, para chlorophenol, phenylphenol, other phenols such as phenylphenol sodium; phenylethyl alcohol, photosensitive Motorui, be mentioned as antibacterial zeolite, silver ion.

  Examples of the chelating agent include edetates (ethylenediaminetetraacetate) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetate such as HEDTA3Na; pentetate (diethylenetriaminepentaacetate); phytic acid; etidronic acid and the like Phosphonic acid and salts such as sodium salts thereof; polyaspartic acid, polyamino acids such as polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine, gluconic acid, Ascorbic acid, succinic acid and tartaric acid are preferred.

  pH adjusters, acids and alkalis include ascorbic acid, citric acid, sodium citrate, lactic acid, sodium lactate, potassium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, Hydrochloric acid, sulfuric acid, monoethanolamine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propane Preferred are diol, arginine, sodium hydroxide, potassium hydroxide, aqueous ammonia, guanidine carbonate and ammonium carbonate.

  As inorganic salts, sodium chloride-containing salts such as common salt, normal salt, rock salt, sea salt, natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, Aluminum potassium potassium sulfate (alum), aluminum ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na / 2Na / 3Na phosphate, phosphoric acid Potassium, calcium phosphate, and magnesium phosphate are preferred.

  Examples of ultraviolet absorbers include para-aminobenzoic acid, para-aminobenzoic acid monoglycerin ester, N, N-dipropoxypara-aminobenzoic acid ethyl ester, N, N-diethoxypara-aminobenzoic acid ethyl ester, N, N-dimethyl-para-aminobenzoic acid ethyl ester Benzoic acid-based ultraviolet absorbers such as esters, N, N-dimethylparaaminobenzoic acid butyl ester, N, N-dimethylparaaminobenzoic acid methyl ester; anthranilic acid-based ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; salicylic acid And salicylic acid purples such as sodium salts thereof, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate, etc. Octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p- Methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, 2-ethylhexyl-p-methoxycinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (cinoxate) , Cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl-α-cyano-β-phenylcinnamate (octocrine), glyceryl mono-2-ethylhexanoyl-diparamethate Cinnamic acid-based ultraviolet absorbers such as xincinnamate, ferulic acid and derivatives thereof; 2,4-dihydroxybenzophenone, 2,2′-dihydroxy-4-methoxybenzophenone, 2,2′-dihydroxy-4,4′-dimethoxybenzophenone; 2,2 ', 4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone -5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4′-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone and the like Benzopheno UV absorbers; 3- (4'-methylbenzylidene) -d, l-camfur; 3-benzylidene-d, l-camfur; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole; 2- (2′-hydroxy-5′-methylphenylbenzotriazole; dibenzarazine; dianisoylmethane; 5- ( 3,3-dimethyl-2-norbornylidene) -3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octyltriazone; urocanic acid derivatives such as urocanic acid and ethyl urocanate 2- (2′-hydroxy-5′-methylphenyl) benzotriazole, Hydantoin derivatives such as-(3,4-dimethoxyphenyl) -4,4-dimethyl-1,3-pentanedione, 2-ethylhexyl dimethoxybenzylidene dioxoimidazolidine propionate, phenylbenzimidazozole sulfonic acid, terephthalyl Preferred are dendicanfursulfonic acid, drometrizole trisiloxane, methyl anthranilate, rutin and its derivatives, and oryzanol and its derivatives.

  Examples of whitening agents include hydroquinone glycosides such as arbutin and α-arbutin and esters thereof; ascorbic acid phosphates such as ascorbic acid, sodium ascorbic acid phosphate and magnesium ascorbic acid phosphate; and ascorbic acid. Fatty acid esters of ascorbic acid such as tetraisopalmitate, alkyl ethers of ascorbic acid such as ethyl ether of ascorbic acid, glucosides of ascorbic acid such as ascorbic acid-2-glucoside and their fatty acid esters, ascorbic acid sulfate, and tocopheryl ascorbyl phosphate And other ascorbic acid derivatives; kojic acid, ellagic acid, tranexamic acid and its derivatives, ferulic acid and its derivatives, placenta extract, glutathione, oryzanol, butylresor Nord, oil-soluble Kamomiraekisu, oil-soluble licorice extract, Nishikawa willow extract, be mentioned as saxifrage extract, and the like plant extracts are preferred.

  As vitamins and derivatives thereof, vitamin A such as retinol, retinol acetate, retinol palmitate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, Flavin adenine dinucleotide, cyanocobalamin, folic acids, nicotinic acids such as nicotinamide and benzyl nicotinate, vitamin Bs such as choline; vitamin Cs such as ascorbic acid and salts thereof such as sodium; vitamin D; vitamins E such as β, γ, δ-tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphate salts such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt; Fatty acid esters of ascorbic acid such as tetraisopalmitic ester of ascorbic acid, ascorbyl stearate, ascorbyl palmitate, and ascorbyl dipalmitate; ascorbic acid alkyl ethers such as ascorbic acid ethyl ether; ascorbic acid glucosides such as ascorbic acid-2-glucoside; Ascorbic acid derivatives such as fatty acid esters and tocopheryl ascorbyl phosphate; vitamin derivatives such as tocopherol derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol linoleate, tocopherol ferulate, and tocopherol phosphate; tocotrienol; and other vitamin derivatives Are preferred.

  As hair growth agents, blood circulation promoters, and stimulants, plant extracts and tinctures such as assembly extract, pepper tincture, ginger tincture, ginger extract, cantharis tincture; capsaicin, nonylate wanilamide, gingerone, ictamol, tannic acid , Borneol, cyclanderate, cinnarizine, tolazoline, acetylcholine, verapamil, cepharanthin, γ-oryzanol, vitamin E and derivatives such as tocopherol nicotinate / tocopherol acetate, γ-oryzanol, nicotinic acid and nicotinamide / nicotinic acid benzyl ester Derivatives of inositol hexanicotinate, nicotine alcohol, etc., allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, flavanonol Conductors, stigmasterol or stigmasteranol and glycosides thereof, and minoxidil are preferred.

  Preferred hormones include estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone, and the like. Other medicinal agents such as anti-wrinkle agents, anti-aging agents, tightening agents, cooling agents, warming agents, wound healing promoters, stimulants, analgesics, cell activators, etc. include retinols, retinoic acids, retinoin Acid tocopheryl; lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and derivatives such as glycosides / esterified products thereof, hydroxycapric acid, long-chain α-hydroxy fatty acid, α- such as long-chain α-hydroxy fatty acid cholesteryl and the like. β-hydroxy acids and derivatives thereof; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; carnosine; creatine; ceramides, sphingosines; caffeine, xanthine, and derivatives thereof; coenzyme Q10, carotene, lycopene , Astaxanthin, lutein, α-lipoic acid, platinum nanocolloids, fullerenes, etc. Catechins; flavones such as quercetin; isoflavones; gallic acid and ester sugar derivatives; tannins, sesamin, protoanthocyanidins, chlorogenic acid, polyphenols such as apple polyphenols; rutin and glycosides; Derivatives of hesperidin and glycosides; lignan glycosides; licorice extract-related substances such as glabridine, glabrene, liquiritin, isoliquiritin; lactoferrin; shogaol, gingerol; fragrance substances such as menthol, cedrol and derivatives thereof; capsaicin , Vanillin and the like and derivatives; insect repellents such as diethyltoluamide; and complexes of physiologically active substances and cyclodextrins are preferred.

  Plant / animal / microbial extracts include iris extract, ashitaba extract, asnaro extract, asparagus extract, avocado extract, amateur extract, almond extract, altea extract, arnica extract, aloe extract, apricot extract, apricot nucleus extract, ginkgo extract , Inchiko extract, Fennel extract, Inchinko extract, Turmeric extract, Oolong tea extract, Uwaurushi extract, Age extract, Echinashi leaf extract, Enmeiso extract, Ogon extract, Oubaku extract, Ouren extract, Barley extract, Panax ginseng extract, Hypericum extract , Botanical extract, Ononis extract, Dutch mustard extract, Orange extract, Seawater dried product, Seaweed extract, Oyster leaf extract, Oyster extract, Hydrolyzed elastin, Water content Wheat powder, hydrolyzed silk, cuckoo extract, chamomile extract, oil-soluble chamomile extract, carrot extract, kawagomugi extract, oat wheat extract, calcade extract, licorice extract, oil-soluble licorice extract, kiwi extract, kiowa extract, jellyfish extract, kina extract, cucumber extract , Kiri leaf extract, Guanosine, Guava extract, Kujin extract, Gardenia extract, Kumazasa extract, Clara extract, Walnut extract, Chestnut extract, Grapefruit extract, Clematis extract, Black rice extract, Brown sugar extract, Black vinegar, Chlorella extract, Mulberry extract, Gentian extract , Gennoshoco extract, Black tea extract, Yeast extract, Koboku extract, Coffee extract, Burdock extract, Rice extract, Rice fermented extract, Rice bran fermented extract, Rice germ oil Comfrey extract, collagen, lingonberry extract, Psychic extract, Psychoextract, Saitai extract, Saffron extract, Salvia extract, Sabonsou extract, Sasa extract, Hawthorn extract, Sansha extract, Sansha extract, Shiitake extract, Jiao extract, Shikon extract, Perilla extract, Linden extract, sycamore extract, jatoba extract, peonies extract, ginger extract, shobu root extract, birch extract, white jellyfish extract, horsetail extract, stevia extract, stevia fermented product, nishikawayanagi extract, edible citrus extract, hawthorn extract, and western elderberry extract , Achillea millefolium extract, Acacia mint extract, Sage extract, Xenopus extract, Senkyu extract, Assembly extract, Sahakuhi extract, Rhubarb extract, soybean extract, syrup extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, chiyaya extract, chimpanzee extract, tea tree oil, bean tea extract, capsicum extract, touki extract, calendula extract, tonin extract, spruce extract, dokudami Extract, Tomato extract, Natto extract, Carrot extract, Garlic extract, Novara extract, Hibiscus extract, Bakmondou extract, Lotus extract, Parsley extract, Birch extract, Honey, Hamamelis extract, Parietaria extract, Hikikoshi extract, Bisabolol, Cypress extract, Bifidus Bacterial extract, loquat extract, coltsfoot extract, fukinotou extract, kukuroyou extract, butcher bloom extract, grape extract, grape seed extract, propo , Luffa extract, safflower extract, peppermint extract, bodaiju extract, button extract, hop extract, squid extract, pine extract, marronnier extract, mizubasho extract, mukuroji extract, melissa extract, mozuku extract, peach extract, cornflower extract, eucalyptus extract, yukinoshita Extract, Yuzu extract, Lily extract, Yokuinin extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract, reishi extract, lettuce extract, lemon extract, forsythia extract, astragalus extract, rose extract, rosemary extract And extracts such as Roman chamomile extract, royal jelly extract, and warmoko extract.

  Examples of the antipruritic include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitor and the like.

  Examples of the exfoliating / dissolving agent include salicylic acid, sulfur, resorcin, selenium sulfide, and pyridoxine.

  Examples of antiperspirants include chlorohydroxyaluminum, aluminum chloride, zinc oxide, zinc paraphenolsulfonate, and the like.

  Examples of the cooling agent include menthol, methyl salicylate, and the like.

  Astringents include citric acid, tartaric acid, lactic acid, aluminum / potassium sulfate, tannic acid and the like.

  Examples of the enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease and the like.

  Preferred nucleic acids include ribonucleic acid and its salts, deoxyribonucleic acid and its salts, and disodium adenosine triphosphate.

  As the fragrance, acetyl cedrene, amyl cinnamaldehyde, allyl amyl glycolate, β-ionone, isoe super, isobutyl quinoline, iris oil, iron, indole, ylang ylang oil, undecanaal, undecenal, γ-undecalactone, Estragole, Eugenol, Oak Moss, Opoponax Resinoid, Orange Oil, Eugenol, Orlanthol, Garrack Solid, Carvacrol, L-Carbon, Camphor, Cannon, Carrot Seed Oil, Clove Oil, Methyl Cinnarate, Geraniol, Geranilnitrile , Isobornyl acetate, geranyl acetate, dimethylbenzylcarbinyl acetate, styryl acetate, ceryl acetate, terpinel acetate, pt-butylcyclohexyl acetate, vetiveryl acetate, benzyl acetate, Linalyl acetate, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamenaldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromyrcenol, jasmine absolute, jasmine lactone, cis-jasmon, citral, citronenol, citronellal Cinnamon bark oil, 1,8-cineole, cinnamaldehyde, stylax resinoid, cedarwood oil, cedren, cedrol, celery seed oil, thyme oil, damascon, damacenone, thymol, tuberose absolute, decanal, decalactone, terpineol, γ-terpinene , Tripral, nerol, nonanal, 2,6-nonadienol, nonalactone, patcholi alcohol, vanilla flies Lute, vanillin, basil oil, patchouli oil, hydroxycitronellal, α-pinene, piperiton, phenethyl alcohol, phenylacetaldehyde, petitglen oil, hexylcinnamaldehyde, cis-3-hexenol, Peruvian balsam, vetiver oil, vetiverol, peppermint oil , Pepper oil, heliotropin, bergamot oil, benzyl benzoate, borneol, milresinoid, musk ketone, methyl nonylacetaldehyde, γ-methyl yonone, menthol, L-menthol, L-menthon, eucalyptus oil, β-yonone, lime oil, lavender oil , D-limonene, linalool, linal, liliar, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, synthetic fragrance such as various essential oils and natural fragrance In addition, various compounded fragrances are preferred.

  Pigments / colorants / dyes include Brown No. 201, Black No. 401, Purple No. 201, Purple No. 401, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 202, Blue No. 203, Blue No. 204, Blue No. 205, Blue 403, Blue 404, Green 201, Green 202, Green 204, Green 205, Green 3, Green 401, Green 402, Red 102, Red 104-1, Red 105-1, red 106, red 2, red 201, red 202, red 203, red 204, red 205, red 206, red 207, red 208, red 213, red 214, Red 215, Red 218, Red 219, Red 220, Red 221, Red 223, Red 225, Red 226, Red 227, Red 228, Red 230-1 Red 230-2, Red 231, Red 232, Red 3, Red 401, Red 404, Red 405, Red 501, Red 502, Red 503, Red 504, Red 505, Red 506, Orange 201, Orange 203, Orange 204, Orange 205, Orange 206, Orange 207, Orange 401, Orange 402, Orange 403, Yellow 201, Yellow 202-1, Yellow 202-2, Yellow 203, Yellow 204, Yellow 205, Yellow 4, Yellow 401, Yellow 402, Yellow 403-1, Yellow 404, Yellow 405, Yellow 406, Yellow 407 Legal dyes such as No. 5 and Yellow No. 5; other acidic dyes such as Acid Red 14; Arianor Sienna Brown, Arianor Madder Red, Ariano Basic dyes such as Steel Blue and Arianor Straw Yellow; HC Yellow 2, HC Yellow 5, HC Red 3, 4-hydroxypropylamino-3, -nitrophenol, N, N'-bis (2-hydroxyethyl-en-2-yl-en-ethyl-n-phenyl) Nitro dyes such as HC Blue 2, Basic Blue 26; disperse dyes; anthraquinones such as astaxanthin and alizarin; anthocyanidins, β-carotene, catenal, capsanthin, chalcone, calsamine, quercetin, crocin, chlorophyll, curcumin, cochineal, shikonin and the like. Naphthoquinones, bixins, flavones, betacyanidins, henna, hemoglobin, lycopene, Natural pigments and dyes such as riboflavin and rutin; p-phenylenediamine, toluene-2,5-diamine, o-, m- or p-aminophenol, m-phenylenediamine, 5-amino-2-methylphenol, resorcinol , 1-naphthol, 2,6-diaminopyridine and the like, and oxidation dye intermediates and couplers thereof; autoxidation dyes such as indoline; and dihydroxyacetone.

  Anti-inflammatory and anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, ketoprofen, ibuprofen, diclofenac, loxoprofen, celecoxib, infliximab, etanercorcept, zinc oxide, hydrochloride, hydrochloride Prednisone, diphedramin hydrochloride, chlorpheniramine maleate; plant extracts such as a peach leaf extract and a maize leaf extract are preferred.

  Anti-asthma, anti-chronic obstructive pulmonary disease, anti-allergy, immunomodulators include aminophylline, theophylline, steroids (fluticasone, beclomethasone, etc.), leukotriene antagonists, thromboxane inhibitors, intal, β2 agonist (Formoterol, salmeterol, albuterol, tulobuterol, clenbuterol, epinephrine, etc.), tiotropium, ipratropium, dextromethorphan, dimemorphan, bromhexine, tranilast, ketotifen, azelastine, cetirizine, chlorpheniramine, mextrezine closlimetine , Cytokine regulators, interferon, omalizumab, protein / antibody preparations are preferred.

  Oseltamivir, zanamivir and itraconazole are preferred as anti-infectives and antifungals. In addition to these, cosmetic raw material standards, cosmetic varieties compounding component standards, Japanese Cosmetic Industry Federation component label name list, INCI dictionary (The International Cosmetic Ingredient Dictionary and Handbook), quasi-drug raw material standards, Japanese Pharmacopoeia, pharmaceutical additive standards Ingredients listed in the Official Addendum of Food Additives, etc., and listed in Japanese and foreign patent publications and patent publications (including published publications and republication) whose international patent classification IPC belongs to the classification of A61K7 and A61K8 It is possible to include known cosmetic ingredients, pharmaceutical ingredients, food ingredients, and the like, in known combinations, in combination ratios and in amounts.

[Method for producing dispersion]
The dispersion of the present invention is a pigment or powder dispersant comprising a lipid peptide compound comprising at least one of the compounds represented by the formulas (1) to (3) or a pharmaceutically usable salt thereof. And at least one selected from the group consisting of surfactants, water, 1,2-alkanediol or 1,3-alkanediol, fatty acids, and pigments and powders, and other additives such as polyhydric alcohols if desired. These are mixed and stirred while heating, and then stirred and cooled to about room temperature.

For example, the dispersion of the present invention is produced, for example, by the following steps.
a) a step of blending the pigment or powder dispersant (lipid peptide compound), a surfactant, and water, and heating to prepare a solution (or dispersion);
b) a step of adding the above-mentioned solution (or dispersion) to water and heating at a temperature of room temperature or higher and lower than 100 ° C;
c) a step of cooling while stirring until the temperature becomes lower than the temperature in the heating step to obtain a dispersion of the present invention.
Here, at least one selected from the group consisting of 1,2-alkanediol or 1,3-alkanediol, a fatty acid, a pigment and a powder, and the other components are a solution (or a dispersion) in the step a). May be added in the preparation step of the above, or may be added in advance to the water to which the solution (or dispersion) is added in the step b).
In addition, the water content may be 60% by mass or more and 99.9% by mass or less based on the total mass of the thus obtained dispersion (including at least one selected from the group consisting of pigments and powders). preferable.

The heating temperature in the steps a) and b) is preferably 50 ° C. to 90 ° C., more preferably 60 ° C. to 90 ° C., for example, 80 ° C., and the stirring is preferably performed while heating. The heating and stirring time in each step at this time varies depending on the type of the pigment or powder dispersant (lipid peptide compound) used, the surfactant and other components, and the amounts thereof, but is usually from 1 minute to 50 minutes. It can be dissolved and dispersed in about a minute.
After the steps a) and b), cooling is performed while stirring until the liquid temperature becomes lower than the temperature in the step b) (step (c)). Here, the cooling temperature is, for example, about room temperature to 80 ° C., room temperature to 60 ° C., or about room temperature to 40 ° C.

The dispersion of the present invention can also be produced by producing an aqueous composition as a premix, and then appropriately adding other components to the premix.
For example, the following is mentioned as a method for producing a dispersion liquid after passing through a premix.
1) Step of preparing a premix 1-1) Surfactant and water, pigment or powder dispersant (compounds represented by the above formulas (1) to (3) or pharmaceutically usable compounds thereof) A heating step of heating the mixed system comprising at least one of salts, a lipid peptide-type compound comprising
1-2) Subsequently, a step of appropriately adding 1,2-alkanediol or 1,3-alkanediol, a fatty acid and other additives to the heated mixed system,
1-3) a step of cooling the solution or dispersion to obtain an aqueous composition (premix);
2) Step of preparing dispersion using premix 2-1) The aqueous composition (premix) heated to room temperature or higher and lower than 100 ° C in an aqueous phase heated to room temperature or higher and lower than 100 ° C. Is added and mixed, or an aqueous phase heated to a temperature of room temperature or more and less than 100 ° C. is added to the aqueous composition (premix) heated to a temperature of room temperature or more and less than 100 ° C., and mixed. Process,
2-2) A cooling step of stirring and cooling the mixture obtained in the mixing step to obtain a dispersion.
The aqueous phase in the step 2-1) contains water, may further contain a higher alcohol, a pigment, and may contain a 1,2-alkanediol or 1,3-alkanediol, a fatty acid, and other additives. . Further, after mixing the pigment and other additives into the aqueous composition (premix) in 2-1), the mixture may be combined with the aqueous phase.
Further, in the mixing step, a dispersion (formulation) to which the drug is added can be produced by further adding a solution of the drug.

In step 1-1) and step 1-2), the heating temperature of the mixed system (and the aqueous composition) is preferably 50 ° C to 90 ° C, more preferably 60 ° C to 90 ° C, for example, 70 ° C or 80 ° C. It is. This step is preferably performed with stirring. The heating (stirring) time in each step at this time varies depending on the type of the pigment or powder dispersant (lipid peptide compound), surfactant, and other components contained in the aqueous composition, and the blending amount thereof. And usually about 5 to 50 minutes. In this step, the aqueous composition is uniformly dissolved.
The cooling temperature in the step 1-3) is, for example, about room temperature to 80 ° C., room temperature to 60 ° C., or about room temperature to 40 ° C. In this step, it is more preferable that the mixture is cooled while stirring, and then the stirring is stopped and the mixture is left standing.
In addition, it is preferable that water is 30 mass% or more and less than 80 mass% with respect to the total mass of the aqueous composition (premix) obtained by 1) process.

  The heating temperature of the aqueous phase and the aqueous composition (premix) in the step 2-1) is preferably 50 ° C to 90 ° C, more preferably 60 ° C to 90 ° C, for example, 70 ° C, or 80 ° C, or 90 ° C. It is. The heating of the aqueous phase is preferably carried out with stirring because it contains other components, and it is preferable to carry out heating (stirring) usually for about 1 to 50 minutes until the contained components are uniformly dissolved and dispersed. The heating temperature of the aqueous phase may be the same as the heating temperature of the aqueous composition (premix).

  Subsequently, in the step 2-2), the mixture obtained in the preceding step is stirred and cooled to obtain a dispersion. When cooling while stirring, for example, the stirring may be performed until the cooling temperature becomes from room temperature to 80 ° C., from room temperature to 60 ° C., for example, about 60 ° C., and then the stirring may be stopped and the mixture may be left standing to cool.

  In the dispersion thus obtained using the aqueous composition (premix), the amount of water is preferably 60% by mass or more and 99.9% by mass or less based on the total mass of the dispersion.

  Hereinafter, the present invention will be described in detail with reference to examples and test examples, but the present invention is not limited to these examples.

[Synthesis Example 1: Synthesis of lipid peptide (N-palmitoyl-Gly-His)]
The lipid peptide type compound used in this example was synthesized by the following method.
In a 500 mL four-necked flask, 14.2 g (91.6 mmol) of histidine, 30.0 g (91.6 mmol) of N-palmitoyl-Gly-methyl, and 300 g of toluene were added, and a 28% methanol solution of sodium methoxide as a base was added. 35.3 g (183.2 mmol) was added, the mixture was heated to 60 ° C. in an oil bath, and stirring was continued for 1 hour. Thereafter, the oil bath was removed, the solution was allowed to cool to 25 ° C., and the solution was reprecipitated with 600 g of acetone and collected by filtration. The solid obtained here was dissolved in a mixed solution of 600 g of water and 750 g of methanol, and 30.5 ml (183.2 mmol) of 6N hydrochloric acid was added thereto for neutralization, and a solid was deposited, followed by filtration. Next, the obtained solid was dissolved in a mixed solution of 120 g of tetrahydrofuran and 30 g of water at 60 ° C, 150 g of ethyl acetate was added, and the mixture was cooled from 60 ° C to 30 ° C. Thereafter, the precipitated solid was filtered. Further, the obtained solid was dissolved in a solvent of 120 g of tetrahydrofuran and 60 g of acetonitrile, heated to 60 ° C., stirred for 1 hour, cooled, and filtered. The solid obtained here was washed with 120 g of water, dried under reduced pressure after filtration, and 26.9 g of white crystals of N-palmitoyl-Gly-His free body (hereinafter, also simply referred to as Pal-GH) (65% yield). %).

[Example 1: Preparation of a liquid foundation containing 10% by mass of a pigment]
According to Table 1 below, a liquid foundation containing 10% by mass of a pigment was prepared.
5.0 g of pigment and 33.0 g of pure water were stirred at 80 ° C. for 2 minutes in a Laboran screw tube bottle (No. 7, AS ONE Corporation), and heated to 80 ° C. for 1,2-hexane. 1.0 g of diol was added and mixed with stirring for 2 minutes.
After adding 1.0 g of the composition [1] heated to 80 ° C. and stirring and mixing for 2 minutes, 10.0 g of glycerin heated to 80 ° C. is added and stirred and mixed for 3 minutes, and the mixture is brought to room temperature. The mixture was stirred and cooled until a liquid foundation was obtained.
The composition [1] had the composition shown in Table 1, and was prepared by mixing Pal-GH, polyoxyethylene lauryl ether and purified water, heating and stirring at 70 ° C., and adding 1,2-hexanediol and stearic acid thereto. After further heating and stirring at 70 ° C., the mixture was allowed to cool to room temperature. In the following examples, the composition [1] obtained by the same procedure was used.
Agitation in the above manufacturing steps was all performed at 400 rpm.

[Example 2: Preparation of water white powder foundation containing 10% by mass of pigment]
A water white powder foundation containing 10% by mass of the pigment shown in Table 1 was produced in the same procedure as in Example 1 except that the composition [1] was changed to 0.5 g and pure water to 33.5 g.

[Example 3: Production of water white powder foundation containing 15% by mass of pigment]
A water white powder foundation containing 15% by mass of the pigment shown in Table 1 was produced in the same procedure as in Example 2 except that 7.5 g of the pigment and 31 g of pure water were used.

[Comparative Example 1]
A foundation of a comparative example containing 10% by mass of the pigment shown in Table 1 was prepared in the same procedure as in Example 1 except that the composition [1] was not blended and pure water was changed to 34.0 g.

FIG. 1 shows the foundations (appearance) of Examples 1 to 3 and Comparative Example 1.
As shown in FIG. 1, in Examples 1 to 3 in which the composition [1] containing Pal-GH was blended, the pigment was dispersed and the dispersion stability of the pigment was confirmed. Further, by adjusting the blending amount of the composition [1] containing Pal-GH, a liquid foundation type having a high viscosity (Example 1) and a water-white powder foundation type having a lower viscosity than the liquid foundation type (Examples 2 and 3) were used. Example 3) could be prepared.
On the other hand, in Comparative Example 1 in which the composition [1] containing Pal-GH was not blended, as shown in FIG. 1, the pigment and other components were separated, and the pigment was precipitated.

[Example 4: Preparation of dispersion containing 2% by mass of pearl pigment]
According to Table 2 below, a dispersion liquid containing 2% by mass of a pearl pigment was prepared.
1.0 g of pearl pigment and 33.5 g of pure water were stirred at 80 ° C. for 2 minutes in a Labolan screw tube (No. 7, As One Corporation), and heated to 80 ° C. for 1,3-. 5.0 g of butylene glycol (1,3-butanediol) was added, and the mixture was stirred and mixed for 2 minutes.
To this, 0.5 g of the composition [1] heated to 80 ° C. is added, and the mixture is stirred and mixed for 2 minutes. Then, 10.0 g of glycerin heated to 80 ° C. is added, and the mixture is stirred and mixed for 3 minutes. The mixture was stirred and cooled until a dispersion was obtained.
Agitation in the above manufacturing steps was all performed at 400 rpm.

[Example 5: Preparation of dispersion containing 0.5% by mass of pearl pigment]
According to Table 2 below, a dispersion liquid containing 0.5% by mass of a pearl pigment was prepared.
In a Labolan screw tube bottle (No. 7, AS ONE Corporation), 0.25 g of pearl pigment and 49.25 g of pure water were stirred at 80 ° C. for 2 minutes, and the composition [1] heated to 80 ° C. ], And the mixture was stirred and mixed for 2 minutes, and then stirred and cooled to room temperature to obtain a dispersion.
Agitation in the above manufacturing steps was all performed at 400 rpm.

[Comparative Example 2]
A dispersion liquid of a comparative example containing 2% by mass of the pearl pigment shown in Table 2 was prepared in the same procedure as in Example 4, except that the composition [1] was not used and pure water was changed to 34.0 g. did.

FIG. 2 shows pearl pigment-containing dispersions (appearance) of Examples 4 and 5 and Comparative Example 2.
As shown in FIG. 2, in Comparative Example 2 in which the composition [1] containing Pal-GH was not blended, the result was that the pearl pigment was separated from the other components and the pearl pigment was precipitated. In Examples 4 and 5 in which the composition [1] was blended, the result was that the dispersibility of the pearl pigment was improved.

[Example 6: Preparation of tricalcium phosphate dispersion]
According to Table 3 below, a dispersion liquid containing 0.5% by mass of tricalcium phosphate was prepared.
A composition prepared by stirring 0.25 g of tricalcium phosphate and 49.25 g of pure water at 80 ° C. for 2 minutes in a Labolan screw tube bottle (No. 7, AS ONE Corporation) and heating to 80 ° C. [1] After adding 0.5 g and stirring and mixing for 2 minutes, the mixture was stirred and cooled to room temperature to obtain a dispersion.
Agitation in the above manufacturing steps was all performed at 400 rpm.

[Comparative Example 3]
Comparative Example in which 0.5% by mass of tricalcium phosphate shown in Table 3 was blended in the same procedure as in Example 5 except that the composition [1] was not blended and pure water was changed to 49.75 g. A dispersion was prepared.

FIG. 3 shows the dispersions (appearance) of the tricalcium phosphate-containing dispersions of Example 6 and Comparative Example 3.
As shown in FIG. 3, in Comparative Example 3 in which the composition [1] containing Pal-GH was not blended, tricalcium phosphate and other components were separated, resulting in precipitation of tricalcium phosphate. However, in Example 6 in which the composition [1] was blended, the result was that the dispersibility of tricalcium phosphate was improved.

[Example 7: Preparation of gold foil 0.01% by mass mixed dispersion]
According to Table 4 below, a dispersion was prepared in which 0.01% by mass of gold foil (about 2 mm square to 10 mm square) was blended.
In a Labolan screw tube bottle (No. 7, As One Co., Ltd.), 5 mg of gold foil and 49.745 g of pure water were stirred at 80 ° C. for 2 minutes, and heated to 80 ° C. for composition [1] 0. After adding 0.25 g and stirring and mixing for 2 minutes, the mixture was stirred and cooled to room temperature to obtain a dispersion.
Agitation in the above manufacturing steps was all performed at 400 rpm.

[Example 8: Preparation of 0.05% by mass of gold foil dispersion]
In the same procedure as in Example 7 except that the gold foil was 25 mg, the composition [1] was 0.5 g, and the pure water was 49.475 g, a dispersion containing 0.05% by mass of the gold foil shown in Table 4 was prepared. Manufactured.

[Comparative Example 4]
The same procedure as in Example 7 was repeated except that the composition [1] was not used and pure water was used in an amount of 49.95 g. Prepared.

FIG. 4 shows the gold foil-containing dispersions (appearance) of Examples 7 and 8 and Comparative Example 4.
As shown in FIG. 4, in Comparative Example 4 in which the composition [1] containing Pal-GH was not blended, the gold foil and other components were separated, and the gold foil floated or precipitated depending on its weight. However, in Examples 7 and 8 in which the composition [1] was blended, the result was that the dispersibility of tricalcium phosphate was improved.
Also, at this time, by adjusting the amount of the composition [1] containing the Pal-GH, the result was that the amount of the gold foil and the transparency of the dispersion could be adjusted.

[Example 9: Preparation of O / W liquid foundation containing 17% by mass of pigment]
According to Table 5 below, a foundation in which 17% by mass of the pigment was uniformly dispersed was prepared.
In a 200 mL beaker (manufactured by HARIO Corporation), 34.0 g of pigment (Fresh Color Base Aqua), 139.6 g of purified water, 0.2 g of sodium N-stearoylmethyltaurine (NIKKOL SMT, Nikko Chemicals Co., Ltd.), lecithin (LPA) Nikko Chemicals Co., Ltd.) 0.2 g, EDTA-2Na (Junsei Chemical Co., Ltd.) 0.2 g, hydroxypropylcellulose (NISSO SSL, Nippon Soda Co., Ltd.) 0.4 g, xanthan gum (KELTROL-CG-ST, 0.4 g of Sanshin Co., Ltd. were mixed and heated and stirred at 75 ° C. for 10 minutes (phase B).
In a 200 mL beaker (manufactured by HARIO Corporation), 4.0 g of NIKKOL Nikomulus 41 (Nikko Chemicals Co., Ltd.), 14.0 g of NIKKOL NATURAL OILS (Nikko Chemicals Co., Ltd.), 1 NIKKOL Nicoguard 88 (Nikko Chemicals Co., Ltd.) 1 Then, the mixture was heated and stirred at 75 ° C. for 10 minutes (phase A).
Phase A is added to Phase B while stirring slowly, and the resulting mixture is used at 75 ° C. for 3 minutes at 5,000 rpm using a homomixer (QUICK HOMO MIXER LR-1A, manufactured by Mizuho Industry Co., Ltd.). Emulsification was performed. Further, 2.0 g of the composition [1] heated to 75 ° C. was added, and the mixture was heated and stirred at 75 ° C. for 2 minutes, followed by stirring and cooling at room temperature until the temperature reached 40 ° C. After confirming that the temperature reached 40 ° C, 4.0 g (C phase) of NIKKOL NET-813-1 (Nikko Chemicals Co., Ltd.) was added, and the mixture was stirred and cooled to 35 ° C.
In the above steps, all stirring was performed at 200 rpm.

[Comparative Example 5]
According to Table 5 below, a foundation containing 17% by mass of a pigment was prepared.
In a 200 mL beaker (manufactured by HARIO Corporation), 34.0 g of pigment (fresh color base aqua), 141.6 g of purified water, 0.2 g of sodium N-stearoylmethyltaurine (NIKKOL SMT, Nikko Chemicals Co., Ltd.), lecithin (LPA) Nikko Chemicals Co., Ltd.) 0.2 g, EDTA-2Na (Junsei Chemical Co., Ltd.) 0.2 g, hydroxypropylcellulose (NISSO SSL, Nippon Soda Co., Ltd.) 0.4 g, xanthan gum (KELTROL-CG-ST, 0.4 g of Sanshin Co., Ltd. were mixed and heated and stirred at 75 ° C. for 10 minutes (phase B).
In a 200 mL beaker (manufactured by HARIO Corporation), 4.0 g of NIKKOL Nikomulus 41 (Nikko Chemicals Co., Ltd.), 14.0 g of NIKKOL NATURAL OILS (Nikko Chemicals Co., Ltd.), 1 NIKKOL Nicoguard 88 (Nikko Chemicals Co., Ltd.) 1 Then, the mixture was heated and stirred at 75 ° C. for 10 minutes (phase A).
Phase A is added to Phase B while stirring slowly, and the resulting mixture is used at 75 ° C. for 3 minutes at 5,000 rpm using a homomixer (QUICK HOMO MIXER LR-1A, manufactured by Mizuho Industry Co., Ltd.). Emulsification was performed. Thereafter, stirring and cooling were performed at room temperature until the temperature reached 40 ° C, 4.0 g (C phase) of NIKKOL NET-813-1 (Nikko Chemicals Co., Ltd.) was added, and the solution was stirred and cooled to 35 ° C.
In the above steps, all stirring was performed at 200 rpm.

  FIG. 5 shows the results of evaluating the pigment dispersibility of the O / W liquid foundations of Example 9 and Comparative Example 5 by observing (photographing) a polarizing microscope (manufactured by Olympus Corporation). As shown in FIG. 5, in Comparative Example 5 in which the composition [1] containing Pal-GH was not blended, a large amount of pigment aggregation was observed, and the dispersibility was non-uniform. In Example 9 in which the composition [1] was blended, the result was that the dispersibility of the pigment was improved.

FIG. 6 shows the O / W liquid foundations (appearance) of Example 9 and Comparative Example 5 after storage for one month after the preparation of the liquid foundation. As shown in FIG. 6, in Comparative Example 5 in which the composition [1] containing Pal-GH was not blended, separation of pigments and oils was observed (in the figure, the state of separation was color unevenness). (Observed), the dispersibility was non-uniform, but in Example 9 in which the composition [1] was blended, the dispersibility of the pigment was improved.

Claims (9)

A surfactant;
water and,
A pigment or powder dispersant comprising a lipid peptide-type compound comprising at least one of the compounds represented by the following formulas (1) to (3) or a pharmaceutically usable salt thereof;
1,2-alkanediol or 1,3-alkanediol;
At least one fatty acid,
Including at least one selected from the group consisting of pigments and powders,
Dispersion.
(Wherein, R ¹ represents an aliphatic group having 9 to 23 carbon atoms, and R ² represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms. R ³ represents a — (CH ₂ ) n —X group, n represents a number of 1 to 4, and X represents 1 to 3 amino groups, guanidino groups, —CONH ₂ groups, or 1 to 3 nitrogen atoms. Represents a 5-membered or 6-membered ring or a condensed heterocyclic ring composed of a 5-membered ring and a 6-membered ring.)
(Wherein, R ⁴ represents an aliphatic group having 9 to 23 carbon atoms, and R ^{5 to} R ⁷ each independently represent a hydrogen atom, a carbon atom which may have a branched chain having 1 or 2 carbon atoms). 1 to 4 alkyl groups, or represents - _(CH 2) n-X group, and at least one of ^{R 5} to ^{R 7} are - _(CH 2) represents an n-X group, n represents 1 to 4 X represents an amino group, a guanidino group, a -CONH ₂ group, or a 5- or 6-membered ring having 1 to 3 nitrogen atoms, or a fused heterocyclic ring composed of a 5- and 6-membered ring. Represents a ring.)
(Wherein, R ⁸ represents an aliphatic group having 9 to 23 carbon atoms, and R ^{9 to} R ¹² each independently represent a hydrogen atom, a carbon atom which may have a branched chain having 1 or 2 carbon atoms). 1 to 4 alkyl groups, or represents - _(CH 2) n-X group, and at least one of ^{R 9} or ^{R 12} is - _(CH 2) represents an n-X group, n represents 1 to 4 X represents an amino group, a guanidino group, a -CONH ₂ group, or a 5- or 6-membered ring having 1 to 3 nitrogen atoms, or a fused heterocyclic ring composed of a 5- and 6-membered ring. Represents a ring.) The dispersion according to claim 1, wherein at least one selected from the group consisting of the pigment and the powder is contained in a proportion of 25% by mass or less based on the total mass of the dispersion. The dispersion according to claim 1 or 2, wherein the pigment or powder dispersant is contained in a ratio of 0.01% by mass to 1% by mass based on the total mass of the dispersion. The dispersion according to any one of claims 1 to 3, further comprising a polyhydric alcohol. The dispersion according to claim 4, wherein the polyhydric alcohol is glycerin. 6. The surfactant according to claim 1, wherein the surfactant is at least one compound selected from the group consisting of ethylene glycol alkyl ether, phospholipid, polyglycerin fatty acid ester, and polyoxyethylene polyoxypropylene alkyl ether. The dispersion according to any one of the above. The dispersion according to any one of claims 1 to 6, wherein the fatty acid is stearic acid. The dispersion according to any one of claims 1 to 7, which is a dispersion for cosmetics. A pigment or powder dispersant comprising a lipid peptide type compound comprising at least one of the compounds represented by the following formulas (1) to (3) or a pharmaceutically usable salt thereof.
(Wherein, R ¹ represents an aliphatic group having 9 to 23 carbon atoms, and R ² represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms. R ³ represents a — (CH ₂ ) n —X group, n represents a number of 1 to 4, and X represents 1 to 3 amino groups, guanidino groups, —CONH ₂ groups, or 1 to 3 nitrogen atoms. Represents a 5-membered or 6-membered ring or a condensed heterocyclic ring composed of a 5-membered ring and a 6-membered ring.)
(Wherein, R ⁴ represents an aliphatic group having 9 to 23 carbon atoms, and R ^{5 to} R ⁷ each independently represent a hydrogen atom, a carbon atom which may have a branched chain having 1 or 2 carbon atoms). 1 to 4 alkyl groups, or represents - _(CH 2) n-X group, and at least one of ^{R 5} to ^{R 7} are - _(CH 2) represents an n-X group, n represents 1 to 4 X represents an amino group, a guanidino group, a -CONH ₂ group, or a 5- or 6-membered ring having 1 to 3 nitrogen atoms, or a fused heterocyclic ring composed of a 5- and 6-membered ring. Represents a ring.)
(Wherein, R ⁸ represents an aliphatic group having 9 to 23 carbon atoms, and R ^{9 to} R ¹² each independently represent a hydrogen atom, a carbon atom which may have a branched chain having 1 or 2 carbon atoms). 1 to 4 alkyl groups, or represents - _(CH 2) n-X group, and at least one of ^{R 9} or ^{R 12} is - _(CH 2) represents an n-X group, n represents 1 to 4 X represents an amino group, a guanidino group, a -CONH ₂ group, or a 5- or 6-membered ring having 1 to 3 nitrogen atoms, or a fused heterocyclic ring composed of a 5- and 6-membered ring. Represents a ring.)