TW201827063A - A use of an extract of Bombax malabaricum DC - Google Patents
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- 239000000284 extract Substances 0.000 title claims abstract description 20
- 244000061474 Bombax ceiba Species 0.000 title 1
- 235000004480 Bombax malabaricum Nutrition 0.000 title 1
- 201000008482 osteoarthritis Diseases 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000003814 drug Substances 0.000 claims abstract description 11
- 244000146553 Ceiba pentandra Species 0.000 claims description 55
- 235000003301 Ceiba pentandra Nutrition 0.000 claims description 55
- 239000006286 aqueous extract Substances 0.000 claims description 21
- 238000000605 extraction Methods 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 7
- 239000002904 solvent Substances 0.000 claims description 5
- 230000037396 body weight Effects 0.000 claims description 4
- 244000293889 Bombax malabaricum Species 0.000 abstract description 3
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 241000700159 Rattus Species 0.000 description 14
- 108090000526 Papain Proteins 0.000 description 9
- 239000004365 Protease Substances 0.000 description 9
- 229940055729 papain Drugs 0.000 description 9
- 235000019834 papain Nutrition 0.000 description 9
- 208000024891 symptom Diseases 0.000 description 8
- 210000003141 lower extremity Anatomy 0.000 description 7
- 239000004480 active ingredient Substances 0.000 description 5
- 239000000843 powder Substances 0.000 description 4
- 241000219071 Malvaceae Species 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 210000000629 knee joint Anatomy 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 208000006820 Arthralgia Diseases 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000012659 Joint disease Diseases 0.000 description 1
- 206010023230 Joint stiffness Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000000287 crude extract Substances 0.000 description 1
- 238000001804 debridement Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 210000001503 joint Anatomy 0.000 description 1
- 208000018937 joint inflammation Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 238000003305 oral gavage Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
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Abstract
Description
本發明係關於一種木棉花水萃物的用途，特別關於一種木棉花水萃物應用於製備治療退化性關節炎的藥物的用途。 The invention relates to the use of an aqueous extract of kapok, in particular to the use of an aqueous extract of kapok to prepare a medicine for treating degenerative arthritis.
退化性關節炎(orteoarthritis，簡稱OA)為由關節軟骨的破壞(breakdown of joint cartilage)所引起的關節疾病(joint disease)，常見的症狀為關節的疼痛與僵硬(stiffness)。 Orthoeoarthritis (OA for short) is a joint disease caused by the breakdown of joint cartilage, and common symptoms are joint pain and stiffness.
臨床上係以被動方式抑制退化性關節炎的惡化或減緩患者的疼痛，例如減輕關節所受到之壓力(decrease joint stress)，及利用NSAID等藥物來減少關節的發炎症狀；或是利用外科手術治療，進行關節鏡清創術(arthroscopic debridement)以修補關節之破裂部位等；惟前述處置仍無法完全根治退化性關節炎。是以，確實有必要發展能夠治療退化性關節炎的藥物。 It is clinically used to passively inhibit the deterioration of degenerative arthritis or reduce the pain of patients, such as reducing joint stress, and using drugs such as NSAID to reduce joint inflammation; or using surgical treatment Arthroscopic debridement was performed to repair the ruptured parts of the joints, etc .; however, the aforementioned treatment still could not completely cure degenerative arthritis. Therefore, it is indeed necessary to develop drugs capable of treating degenerative arthritis.
為解決上述問題，本發明提供一種木棉花水萃物的用途，係將萃取自木棉花之活性成分，應用於製備治療退化性關節炎的藥物者。 In order to solve the above-mentioned problems, the present invention provides the use of a kapok aqueous extract, which uses the active ingredients extracted from kapok to apply to the preparation of a medicine for treating degenerative arthritis.
本發明之木棉花水萃物的用途，係應用於製備治療退化性關節炎的藥物，其中，該木棉花水萃物係水於115~125℃之溫度、0.35~0.5Kg/cm2G之壓力下萃取1.5~3小時所獲得，較佳地，該木棉花水萃物係能夠以口服方式投予一所需個體，且該木棉花水萃物之每天投予該所需個體之劑量為2.5~5毫克/公斤體重；如此藉由萃取自木棉花之活性成分，可以 減緩木瓜蛋白酶所誘發的退化性關節炎症狀，因而可以應用於製備治療退化性關節炎的藥物，為本發明之功效。 The use of the kapok water extract of the present invention is applied to the preparation of a medicine for treating degenerative arthritis, wherein the kapok water extract is water at a temperature of 115-125 ° C and a temperature of 0.35-0.5 Kg / cm 2 G. It is obtained by extracting for 1.5 to 3 hours under pressure. Preferably, the kapok aqueous extract can be administered orally to a desired individual, and the daily dosage of the kapok aqueous extract to the desired individual is 2.5 ~ 5 mg / kg body weight; so the active ingredients extracted from kapok can slow down the symptoms of degenerative arthritis induced by papain, so it can be applied to the preparation of medicine for treating degenerative arthritis, which is the efficacy of the present invention .
第1圖：試驗(A)中第A0~A2組大鼠於跑步機上持續跑步的時間。 Fig. 1: Duration of running of rats in groups A0 ~ A2 on a treadmill in test (A).
第2a圖：試驗(B)中第B0~B2組大鼠於1個月後的右後肢負重百分比。 Figure 2a: Percent weight bearing of the right hind limb of rats in group B0 ~ B2 in test (B) after 1 month.
第2b圖：試驗(B)中第B0~B2組大鼠於3個月後的右後肢負重百分比。 Figure 2b: Percent weight bearing of right hind limbs of rats in group B0 ~ B2 in test (B) after 3 months.
為讓本發明之上述及其他目的、特徵及優點能更明顯易懂，下文特舉本發明之較佳實施例，並配合所附圖式，作詳細說明如下：本發明所述之「木棉(Bombax malabaricum DC.)」，係指木棉科(Bombacaceae)木棉屬(malabaricum)的植物，其花朵(即，木棉花)清熱解毒，常被用於煲湯。 In order to make the above and other objects, features, and advantages of the present invention more comprehensible, the following describes the preferred embodiments of the present invention and the accompanying drawings in detail, as follows: The "kapok ( Bombax malabaricum DC.) "means Bombacaceae (Bombacaceae) bombax (malabaricum) of the plant, its flowers (ie, kapok) detoxification, often used in soup.
本發明之木棉花水萃物，係可以減緩木瓜蛋白酶所誘發的退化性關節炎症狀，因而可以應用於製備治療退化性關節炎的藥物，因而可以應用於製備治療退化性關節炎的藥物，該木棉花水萃物與醫藥學上可以接受之載劑或賦形劑組合形成一醫藥組合物，其中，該木棉花水萃物係可以製備成任何方便食用之型式，如錠劑、膠囊、粉劑、粒劑或液劑等，或者將該木棉花水萃物與其他食品或飲料組合，以適於食用之樣態供生物體以口服方式服用。 The kapok aqueous extract of the present invention can alleviate the symptoms of degenerative arthritis induced by papain, and thus can be applied to the preparation of a medicine for treating degenerative arthritis, and thus can be applied to the preparation of a medicine for treating degenerative arthritis. The kapok aqueous extract is combined with a pharmaceutically acceptable carrier or excipient to form a pharmaceutical composition. The kapok aqueous extract can be prepared into any convenient form, such as tablets, capsules, and powders. , Granules, liquids, etc., or the kapok water extract is combined with other foods or beverages for the organism to take orally in a form suitable for consumption.
又，本發明之木棉花水萃物係可以供投予一所需個體，例如以2.5~5毫克/公斤體重之劑量投予該所需個體，使該木棉花水萃物係所含有之活性成分得以於該所需個體體內作用，而可以減緩木瓜蛋白酶所誘發 的退化性關節炎症狀。 In addition, the kapok aqueous extract of the present invention can be administered to a desired individual, for example, at a dose of 2.5 to 5 mg / kg body weight, the desired individual can be administered to make the kapok aqueous extract active. The ingredients work in the body of the desired individual and can slow down the symptoms of degenerative arthritis induced by papain.
其中，該木棉花水萃物較佳係可以藉由一包含以下步驟之方法所製得：提供一木棉花樣品；以水作為一萃取溶劑萃取該木棉花樣品；及將木棉花粗萃液進行濃縮，以獲得該木棉花水萃物。 Among them, the aqueous extract of kapok is preferably prepared by a method comprising the following steps: providing a kapok sample; extracting the kapok sample with water as an extraction solvent; and performing a crude kapok extract Concentrated to obtain the aqueous extract of kapok.
詳而言之，係可以預先將該木棉花樣品於110~120℃之溫度下進行乾燥(將100克木棉花樣品乾燥至20克)，得到一木棉花乾燥物；此外，該木棉花樣品亦可以預先碎成粉粒(粒徑約為1~2mm)，以增加該木棉花樣品與該萃取溶劑之接觸表面積，藉此提升後續萃取之萃取效率。 Specifically, the kapok sample can be dried in advance at a temperature of 110 to 120 ° C (a 100 g kapok sample is dried to 20 g) to obtain a dried kapok material; in addition, the kapok sample is also It can be crushed into powder particles (particle size is about 1 ~ 2mm) in advance to increase the contact surface area of the kapok sample and the extraction solvent, thereby improving the extraction efficiency of subsequent extraction.
舉例而言，每4.8公斤之木棉花樣品係能夠混合該萃取溶劑，使二者總體積達80公升，並於115~125℃之溫度、0.35~0.5Kg/cm2G之壓力下進行萃取1.5~3小時，上述萃取亦可以重複數次，使該木棉花樣品所富含之活性成分可以完整溶出於該萃取溶劑，此為本發明所屬技術領域中具有通常知識者所廣泛應用，在此不加以贅述。 For example, every 4.8 kg of kapok sample can be mixed with the extraction solvent so that the total volume of the two reaches 80 liters, and the extraction is performed at a temperature of 115 to 125 ° C and a pressure of 0.35 to 0.5 Kg / cm 2 G. For ~ 3 hours, the above extraction can also be repeated several times, so that the active ingredients contained in the kapok sample can be completely dissolved in the extraction solvent. This is widely used by those with ordinary knowledge in the technical field to which this invention belongs. To repeat it.
前述之木棉花粗萃液可以經過減壓濃縮及冷凍乾燥，以獲得該木棉花水萃物，藉由此一程序，係可以使該木棉花水萃物之活性成分更加濃縮，是以僅需使用少量之該木棉花水萃物即可以發揮最佳療效。 The aforementioned crude extract of kapok can be concentrated under reduced pressure and freeze-dried to obtain the aqueous extract of kapok. By this procedure, the active ingredients of the aqueous extract of kapok can be more concentrated. Use a small amount of this kapok water extract for best results.
為證實本發明之木棉花水萃物係可以減緩木瓜蛋白酶所誘發的退化性關節炎症狀，遂將每4.8公斤之木棉花樣品萃取所得之木棉花粗萃液，經過減壓濃縮及冷凍乾燥獲得共800克之木棉花水萃物粉末，另將5克之木棉花水萃物粉末溶於20毫升之水後，進行以下試驗。 In order to confirm that the aqueous extract of kapok of the present invention can reduce the symptoms of degenerative arthritis induced by papain, a crude kapok extract obtained by extracting every 4.8 kg of kapok sample was obtained by concentration under reduced pressure and freeze-drying. A total of 800 grams of kapok water extract powder was dissolved. After 5 grams of kapok water extract powder was dissolved in 20 ml of water, the following test was performed.
(A)跑步功能試驗 (A) Running function test
本試驗係選用SD大鼠(Sprague Dawley rat)進行試驗，係於右膝關節(knee joint)注射木瓜蛋白酶(papain)，以誘發退化性關節炎的發生。 This test was performed using SD rats (Sprague Dawley rats). The right knee joint was injected with papain to induce the occurrence of degenerative arthritis.
續分別以如第1表所示之木棉花水萃物連續經口灌食各組 大鼠共3個月(每天一次)後，讓各組大鼠於跑步機(treadmill machine)上跑步(跑步機的速度為16m/s)，並記錄各組大鼠持續跑步的時間。 Continue to orally administer the kapok water extract as shown in Table 1 to each group of rats for 3 months (once a day), and then let the rats of each group run on a treadmill machine (run The speed of the machine is 16m / s), and the continuous running time of each group of rats is recorded.
請參照第1圖所示，相較於未經口灌食木棉花水萃物的第A0組大鼠，經口灌食濃度為2.5~5mg/kg的木棉花水萃物的第A1、A2組大鼠均可以於跑步機上持續跑步較長的時間，顯示本發明木棉花水萃物的投予可以有效降低木瓜蛋白酶所誘發的退化性關節炎症狀。 Please refer to Fig. 1. Compared with group A0 rats, which were not orally administrated the water extract of Kapok, the animals were administrated with the water extracts A1 and A2 of Kapok cotton at a concentration of 2.5-5 mg / kg. All rats in the group can continue to run on the treadmill for a longer period of time, showing that the administration of the aqueous extract of kapok of the invention can effectively reduce the symptoms of degenerative arthritis induced by papain.
(B)負重功能試驗 (B) Load-bearing function test
本試驗同樣以木瓜蛋白酶於SD大鼠的右膝關節誘發退化性關節炎的發生，續分別以如第2表所示之木棉花水萃物連續經口餵食各組大鼠共3個月(每天一次)後，分別讓各組大鼠僅以後肢站立，並記錄兩側後肢的負重差值。 In this test, papain induced the occurrence of degenerative arthritis in the right knee joint of SD rats. The rats were continuously fed orally with the kapok water extract as shown in Table 2 for a total of 3 months ( Once a day), the rats in each group were allowed to stand only on the hind limbs, and the weight difference between the hind limbs on both sides was recorded.
請參照第2a、2b圖所示，未經口灌食木棉花水萃物的第B0組大鼠會由於右後肢退化性關節炎的發生而減少右後肢的負重，經口灌食濃度為2.5~5mg/kg的木棉花水萃物的第B1、B2組大鼠，無論在連續餵 食1個月或3個月均能夠以兩側後肢平均負擔其體重，同樣顯示本發明木棉花水萃物的投予可以有效降低木瓜蛋白酶所誘發的退化性關節炎症狀。 Please refer to Figures 2a and 2b. Group B0 rats without oral gavage of Kapok water extract will reduce the weight of the right hind limb due to the occurrence of degenerative arthritis of the right hind limb. The oral concentration is 2.5. Rats in groups B1 and B2 of ~ 5mg / kg of kapok water extract can bear their body weight evenly on both hind limbs regardless of continuous feeding for 1 month or 3 months, which also shows the kapok water extract of the present invention Administration can effectively reduce the symptoms of degenerative arthritis induced by papain.
綜合上述，本發明之木棉花水萃物的用途係藉由萃取自木棉花之活性成分，可以減緩木瓜蛋白酶所誘發的退化性關節炎症狀，因而可以應用於製備治療退化性關節炎的藥物，為本發明之功效。 In summary, the use of the kapok aqueous extract of the present invention is to reduce the symptoms of degenerative arthritis induced by papain by using the active ingredients extracted from kapok, so it can be applied to the preparation of medicines for degenerative arthritis. It is the effect of the present invention.
雖然本發明已利用上述較佳實施例揭示，然其並非用以限定本發明，任何熟習此技藝者在不脫離本發明之精神和範圍之內，相對上述實施例進行各種更動與修改仍屬本發明所保護之技術範疇，因此本發明之保護範圍當視後附之申請專利範圍所界定者為準。 Although the present invention has been disclosed using the above-mentioned preferred embodiments, it is not intended to limit the present invention. Anyone skilled in the art can make various changes and modifications to the above embodiments without departing from the spirit and scope of the present invention. The technical scope protected by the invention, so the scope of protection of the present invention shall be determined by the scope of the appended patent application.
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| Application Number | Priority Date | Filing Date | Title |
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| TW106101440A TWI594760B (en) | 2017-01-16 | 2017-01-16 | A use of an extract of bombax malabaricum dc. |
| CN201780083378.4A CN110290796A (en) | 2017-01-16 | 2017-12-26 | The method for treating degenerative arthritis |
| PCT/US2017/068416 WO2018132256A1 (en) | 2017-01-16 | 2017-12-26 | Method for treating osteoarthritis |
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| TW106101440A TWI594760B (en) | 2017-01-16 | 2017-01-16 | A use of an extract of bombax malabaricum dc. |
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| TW201827063A true TW201827063A (en) | 2018-08-01 |
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2017
- 2017-01-16 TW TW106101440A patent/TWI594760B/en not_active IP Right Cessation
- 2017-12-26 WO PCT/US2017/068416 patent/WO2018132256A1/en active Application Filing
- 2017-12-26 CN CN201780083378.4A patent/CN110290796A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2018132256A1 (en) | 2018-07-19 |
| TWI594760B (en) | 2017-08-11 |
| CN110290796A (en) | 2019-09-27 |
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