KR101605107B1 - Method of arthritis antiinflammation product from Eucommia ulmoides and Acanthopanax sessiliflorum Seeman by applying microemusion as extraction solvent - Google Patents

Abstract

The present invention relates to a cosmetic composition comprising 0.1 to 4.5% by weight of a fat-soluble solvent comprising at least one of mango butter, shea butter, coconut oil and a fatty acid of stearic acid and palmitic acid; 95 to 99.5% by weight of a polar solvent containing at least one of purified water, water, and alcohols in the alcohol; (S1) of preparing a microemulsion from 0.1 to 0.5% by weight of an emulsifying agent which is a wax, glycerol monostearate or saponin, and (S2) pulverizing the bugs and oak to a size (particle size) of 50 to 100 탆, (Step S3) of mixing the pulverized product of the above-mentioned bugs and crumbs at a weight ratio of 1: 4: 4 to 1, and adding a microemulsion to the pulverized product at a weight ratio of 1: 6 to 10 to obtain an extract The present invention provides a method for producing a supplementary food using a mushroom and an augar which is constituted so as to contain a mushroom and an apple, Inflammatory action, anti-inflammatory analgesic action, and joint tissue-degrading enzyme action, it can help prevent or treat osteoarthritis. Besides, it is composed of pure herbal medicine as compared with drugs widely used as conventional analgesic agents Therefore, it can be supplied at low price because it is safe for human body and easy to supply and receive raw materials, so that the economic burden of joint patients can be reduced, and it is provided in various forms such as beverage, granule, It can be easily and easily eaten, and it is a very useful invention that can contribute to the income increase of farmers who produce two or three kinds of oak.

Description

Technical Field [0001] The present invention relates to a method for producing a microemulsion by using a microemulsion extraction solvent and a microemulsion as extraction solvent,

More particularly, the present invention relates to a method for producing a supplementary food by using a microemulsion and an augar as a main ingredient, And OGFP are provided, it is possible to prevent side effects of gastric diseases such as heartburn and gastrointestinal bleeding during long-term use, to prevent complications, to help maintain normal blood glucose and normal lipids, to maintain proper blood pressure The present invention relates to a method for producing a supplementary food using a bamboo shoot and an augar which is capable of preventing complications in a subject.

In general, osteoarthritis (OA) is the most common athlete's disease, accounting for 40 to 60% of all osteoarthritic diseases, and the prevalence rate is steadily increasing with the increase in the mean age.

These arthritic joints cause the articular cartilage to be worn out, causing the joint bones to strike and cause severe joint pain, and the resulting limitation of activity is the main cause of the disability. Long-term treatment is necessary due to the chronic nature of the disease, and complications and adverse reactions arise from long-term drug use. Therefore, in the treatment of arthritis, it is necessary to develop a therapeutic agent that can alleviate the pain, maintain and recover the articular cartilage function as well as complications.

In addition, the existing method of treating arthritis is to focus on eliminating the pain by taking simple painkiller when there is only pain in the early stage. However, if the pain continues after more advanced painkillers, .

 These anti-inflammatory analgesics will use anti-inflammatory substances of the Corticosteroid type.

For example, when long-term use of hydrocortisone and betamethasone, a kind of anti-inflammatory analgesic, has side effects such as gastric, liver and kidney function that inhibits the regenerating ability of cartilage cells, In principle, intra-articular injection should be performed, not oral administration. Therefore, many medicines have been developed which have analgesic and antiinflammatory effects and lower the above-mentioned side effects in the most common drug administration methods for treating arthritis. Typical examples thereof include diclofenac, aspirin, and Ibuprofen Of nonsteroidal anti-inflammatory drugs (NSAIDs).

Nonsteroidal anti-inflammatory drugs, however, also have side effects that cause side effects in the digestive system, especially the stomach. They also have the effect of eliminating pain and inflammation without the underlying treatment of arthritis.

Among various herbal ingredients, isoflavones and saponins have been introduced as safe anti-inflammatory substances. Most of the extraction methods are extraction with water or alcohol. At this time, the heating process is required. Isoflavones have an antioxidant capacity that is necessary for anti-inflammatory actions.

In addition, there are lipophilic substances in herbal medicines that do not dissolve in water or alcohol, such as pigments. These pigments have high antioxidant ability and are very useful for inflammation such as arthritis. Since they can not be extracted as polar solvents, Inefficient.

Accordingly, the present invention has been made to overcome the above-mentioned problems, and it is an object of the present invention to provide a supplementary food containing chitosan and anthocyanin as main ingredients, thereby preventing side effects of gastric diseases such as heartburn during long- It is effective for prevention and treatment of osteoarthritis because it is effective for decomposition enzyme action, and it is composed of pure herbal medicine as compared with drugs widely used as conventional analgesic agent, so there is no side effect, and it is safe for human body, Since it can be supplied at a low price, it can reduce the economic burden of patients with joints, and the extraction cost can be lowered by using the low temperature microemulsion, and it is provided in various forms such as beverage, granule, It can be easily and easily eaten, contributing to the income increase of farmers producing diapauses and augments It can be used to provide a method of using supplements senticosus Eucommia and so has its purpose.

In order to accomplish the above object, the present invention provides a method for preparing an auxiliary food using a mite extract and an augar, comprising the steps of: mixing and mixing a mango butter, a cedar butter, a coconut oil, and a fatty acid comprising at least one of fatty acids of stearic acid and palmitic acid; 0.1 to 4.5 wt% solvent; 95 to 99.5% by weight of a polar solvent containing at least one of purified water, water, and alcohols in the alcohol; (S1) of preparing a microemulsion from 0.1 to 0.5% by weight of an emulsifying agent which is a wax, glycerol monostearate or saponin, and (S2) pulverizing the bugs and oak to a size (particle size) of 50 to 100 탆, (Step S3) of mixing the pulverized product of the above-mentioned bugs and crumbs at a weight ratio of 1: 4: 4 to 1, and adding a microemulsion to the pulverized product at a weight ratio of 1: 6 to 10 to obtain an extract And the like.

In addition, the method further comprises the step (S4) of mixing the extract with a microemulsion at a weight ratio of 1: 5 to 10 and formulating it into beverage, granule, ring or capsule.

As described above, the present invention provides a microemulsion prepared by mixing a fat or a small amount of alcohol with a fat, and extracting the components useful for anti-arthritis in diabetic rats and ogapi economically and without disturbing the efficacy of the components, As well as components that have high antioxidant potential, such as antioxidants.

The present invention is not limited to bugs and ogapi, and can be applied to a wide range of applications for extraction of all herbal medicine materials.

The above and other objects, features, and advantages of the present invention will become more apparent from the following detailed description of the present invention when taken in conjunction with the accompanying drawings.

A method for preparing supplementary food using a bug and an augar according to the present invention comprises the steps of: 0.1 to 4.5% by weight of a fat-soluble solvent containing at least one of a mixed-preservative component of mango butter, shea butter and palm oil, and fatty acids of stearic acid and palmitic acid; 95 to 99.5% by weight of a polar solvent containing at least one of purified water, water, and alcohols in the alcohol; (S1) of preparing a microemulsion from 0.1 to 0.5% by weight of an emulsifying agent which is a wax, glycerol monostearate or saponin, and (S2) pulverizing the bugs and oak to a size (particle size) of 50 to 100 탆, (Step S3) of mixing the pulverized product of the above-mentioned bugs and crumbs at a weight ratio of 1: 4: 4 to 1, and adding a microemulsion to the pulverized product at a weight ratio of 1: 6 to 10 to obtain an extract .

Also, the method may further comprise the step (S4) of mixing the extract with a microemulsion at a weight ratio of 1: 5 to 10, and formulating it into beverage, granule, ring, or capsule.

Eucommia ulmoides is a bark of the mulberry tree belonging to the mulberry tree, generally called "mulberry", sweet and slightly pungent, warm and non-toxic. Geniposidic acid, iridoids, chlorogenic acid and caffeic acid are known. Among them, Geniposidic acid is known to have a very high anti-inflammatory activity.

Geniposidic acid may also lower blood pressure and produce a nervous stabilization effect.

The pharmacological effects of the above-mentioned phytopathogenic fungi include nonspecific immune enhancement, antioxidant and anti-fatigue action, and major components are ciwujianoside AE, eleutheroside B, eleutherosides AM, friedelin, isofraxidin and acanthoside- The so-called eleutheroside B and recently called Taiwanin C have very good anti-inflammatory properties.

The main ingredients of the alephea are essential oil, tannin, saponin, palmitic acid, sesamin, savinin, acanthoside, and vitamin A. B1.

Hereinafter, the production process of the present invention will be described in detail.

[Example 1] Microemulsion preparation step (S1)

First, 0.1 to 4.5% by weight of a fat-soluble solvent containing at least one of a mixed-preservative component such as mango butter, shea butter, palm oil, and fatty acids such as stearic acid and palmitic acid; 95 to 99.5% by weight of a polar solvent containing at least one of purified water, water, and alcohols in the alcohol; 0.1 to 0.5% by weight of an emulsifier which refers to the wax, glycerol monostearate, and saponin;

The mixed oil or fat such as mango butter, sea butter, coconut oil, etc. is a raw material of a microemulsion as a natural complex emulsifier, and the oil component also plays a role of extracting two kinds of pigments.

The non-pyrogenic acid such as stearic acid, palmitic acid and the like is a raw material for microemulsion as a natural pure emulsifier.

The amount of the fat soluble solvent is 0.1 to 4.5% by weight and the polar solvent is 95 to 99.5% by weight because the amount of the lipophilic substance in the herbal medicine is 0.1 to 4.5% by weight and the amount of the polar substance is mostly, A solvent is preferably used.

The emulsifier is emulsified with a fat-soluble solvent and a polar solvent and added in a small amount to prepare a stable emulsion.

[Example 2] The pulverization step (S2)

Next, the moss and the moss are crushed to a size (particle size) of 50 to 100 mu m.

The pulverization is carried out using a ball mill or a wheeler mill type pulverizer. The pulverization is usually carried out at 1000-3000 rpm for 1 to 5 minutes in order to obtain 1 kg of pulverized product.

[Example 3] Step (S3) of obtaining an extract [

Next, the pulverized product of the two microbes and the microbes are mixed at a weight ratio of 1: 4: 4 to 1, and then the microemulsion is added to the mixed pulverized product at a weight ratio of 1: 6 to 10 to obtain an extract.

The extraction solvent is a microemulsion prepared by diluting purified water, alcohol or alcohol with distilled water to a concentration of 10 to 80%, and 0.01 to 0.1% by weight of an organic acid such as acetic acid or citric acid is contained in the extraction solvent.

The microemulsion is added to the pulverized product of the mites and acacia at a weight ratio of 6 to 10 times and circulated and extracted at a temperature of 30 to 80 ° C for 10 to 30 minutes.

Of course, it is of course possible to obtain the extract by extracting the pulverized product of the bivalves and the oak through the other hot water extraction method, solvent extraction method and the like.

[Example 4] Formulation of extract (S4)

The microemulsion is mixed with the extract at a weight ratio of 1: 5 to 10, and the mixture is formulated into beverage, granule, ring, or capsule.

Mixing at the weight ratio of 1: 5 to 10 is intended to obtain a sufficient extraction effect, and a method of formulating the same is well known in the art, so that a description thereof will be omitted.

Although the present invention has been described with reference to the exemplary embodiments, it is to be understood that the present invention is not limited to the disclosed exemplary embodiments, and that various changes and modifications will be apparent to those skilled in the art. Various modifications and variations are possible within the scope of the claims.

Claims (2)

0.1 to 4.5% by weight of a fat-soluble solvent containing at least one of a mixed and maintained component of mango butter, shea butter and palm oil, and fatty acids of stearic acid and palmitic acid; 95 to 99.5% by weight of a polar solvent comprising at least one of purified water, water and alcohol; (S1) of preparing a microemulsion with 0.1 to 0.5% by weight of an emulsifier containing at least one of wax, glycerol monostearate, and saponin, and pulverizing the bugs and oak to a size (particle size) of 50 to 100 탆 (2) mixing the microcapsules and the crumbs of the ovalbark at a weight ratio of 1: 4: 4 to 1, and then adding the microemulsion to the mixed pulverized product at a weight ratio of 1: 6 to 10 to obtain an extract S3). ≪ / RTI >< RTI ID = 0.0 > 31. < / RTI >
The method according to claim 1,
(4) mixing the extract with a microemulsion at a weight ratio of 1: 5 to 10 and formulating it into beverage, granule, ring, or capsule (S4). Way.