TW201804997A - 高劑量拉喹莫德(laquinimod)於治療多發性硬化症之用途 - Google Patents

高劑量拉喹莫德(laquinimod)於治療多發性硬化症之用途 Download PDF

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Publication number
TW201804997A
TW201804997A TW106117959A TW106117959A TW201804997A TW 201804997 A TW201804997 A TW 201804997A TW 106117959 A TW106117959 A TW 106117959A TW 106117959 A TW106117959 A TW 106117959A TW 201804997 A TW201804997 A TW 201804997A
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TW
Taiwan
Prior art keywords
drug
laquinimod
patient
multiple sclerosis
score
Prior art date
Application number
TW106117959A
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English (en)
Chinese (zh)
Inventor
巴茲哈爾丹
Original Assignee
以色列商泰瓦藥品工業有限公司
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Application filed by 以色列商泰瓦藥品工業有限公司 filed Critical 以色列商泰瓦藥品工業有限公司
Publication of TW201804997A publication Critical patent/TW201804997A/zh

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/47042-Quinolinones, e.g. carbostyril
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW106117959A 2012-05-02 2013-04-29 高劑量拉喹莫德(laquinimod)於治療多發性硬化症之用途 TW201804997A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261641389P 2012-05-02 2012-05-02
US61/641,389 2012-05-02

Publications (1)

Publication Number Publication Date
TW201804997A true TW201804997A (zh) 2018-02-16

Family

ID=49514859

Family Applications (2)

Application Number Title Priority Date Filing Date
TW106117959A TW201804997A (zh) 2012-05-02 2013-04-29 高劑量拉喹莫德(laquinimod)於治療多發性硬化症之用途
TW102115308A TW201347762A (zh) 2012-05-02 2013-04-29 高劑量拉喹莫德(laquinimod)於治療多發性硬化症之用途

Family Applications After (1)

Application Number Title Priority Date Filing Date
TW102115308A TW201347762A (zh) 2012-05-02 2013-04-29 高劑量拉喹莫德(laquinimod)於治療多發性硬化症之用途

Country Status (21)

Country Link
US (3) US20130303569A1 (enExample)
EP (1) EP2844255A4 (enExample)
JP (2) JP2015515985A (enExample)
KR (1) KR20150013658A (enExample)
CN (2) CN105832733A (enExample)
AR (1) AR090885A1 (enExample)
AU (1) AU2013256352A1 (enExample)
BR (1) BR112014027010A2 (enExample)
CA (1) CA2870684A1 (enExample)
CL (1) CL2014002935A1 (enExample)
EA (1) EA201492010A1 (enExample)
HK (1) HK1206246A1 (enExample)
IL (1) IL235337A0 (enExample)
MX (1) MX2014013039A (enExample)
PE (1) PE20150161A1 (enExample)
PH (1) PH12014502447A1 (enExample)
SG (1) SG11201406594UA (enExample)
TW (2) TW201804997A (enExample)
UY (1) UY34775A (enExample)
WO (1) WO2013166166A1 (enExample)
ZA (1) ZA201408820B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013055907A1 (en) 2011-10-12 2013-04-18 Teva Pharmaceutical Industries Ltd. Treatment of multiple sclerosis with combination of laquinimod and fingolimod
AU2013214909A1 (en) 2012-02-03 2014-09-18 Teva Pharmaceutical Industries Ltd. Use of laquinimod for treating Crohn's disease patients who failed first-line anti-TNFa therapy
AR090073A1 (es) 2012-02-16 2014-10-15 Teva Pharma N-etil-n-fenil-1,2-dihidro-4,5-di-hidroxi-1-metil-2-oxo-3-quinolinacarboxamida, su preparacion y usos
US20130259856A1 (en) * 2012-03-27 2013-10-03 Teva Pharmaceutical Industries, Ltd. Treatment of multiple sclerosis with combination of laquinimod and dimethyl fumarate
TW201400117A (zh) 2012-06-05 2014-01-01 Teva Pharma 使用拉喹莫德治療眼發炎疾病
TW201410244A (zh) 2012-08-13 2014-03-16 Teva Pharma 用於治療gaba媒介之疾病之拉喹莫德(laquinimod)
CA2884272A1 (en) * 2012-10-12 2014-04-17 Giancarlo Comi Laquinimod for reducing thalamic damage in multiple sclerosis
KR20150091077A (ko) 2012-11-07 2015-08-07 테바 파마슈티컬 인더스트리즈 리미티드 라퀴니모드의 아민염
JP2016510343A (ja) * 2013-02-15 2016-04-07 テバ ファーマシューティカル インダストリーズ リミティド ラキニモドを用いる多発性硬化症の治療
EP2970129A2 (en) 2013-03-14 2016-01-20 Teva Pharmaceutical Industries Ltd. Crystals of laquinimod sodium and improved process for the manufacture thereof
AR098924A1 (es) * 2013-12-23 2016-06-22 Teva Pharma Tratamiento de la esclerosis múltiple con una combinación de laquinimod y teriflunomida
SG11201608674UA (en) * 2014-04-29 2016-11-29 Teva Pharma Laquinimod for the treatment of relapsing-remitting multiple sclerosis (rrms) patients with a high disability status
WO2017027512A1 (en) * 2015-08-13 2017-02-16 Teva Pharmaceutical Industries Ltd. Use of laquinimod to treat traumatic brain injury
US20190108912A1 (en) * 2017-10-05 2019-04-11 Iquity, Inc. Methods for predicting or detecting disease
TWI879737B (zh) * 2018-07-20 2025-04-11 德商馬克專利公司 利用經取代胺基-嘧啶化合物治療及預防多發性硬化症之方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6077851A (en) * 1998-04-27 2000-06-20 Active Biotech Ab Quinoline derivatives
HRP20160455T1 (hr) * 2004-09-09 2016-07-15 Yeda Research And Development Co., Ltd. Smjese polipeptida, sastavi koji ih sadrže i postupci za njihovu pripremu, te njihove primjene
US20080118553A1 (en) * 2006-06-12 2008-05-22 Anton Frenkel Tannate salt form of polypeptide mixtures, their preparation and use
BR112012000568A2 (pt) * 2009-06-19 2015-10-06 Teva Pharma tratamento da esclerose múltipla com laquinimod
EP2523668A1 (en) * 2010-01-13 2012-11-21 Ramot at Tel-Aviv University Ltd Treatment of multiple sclerosis
WO2013055907A1 (en) * 2011-10-12 2013-04-18 Teva Pharmaceutical Industries Ltd. Treatment of multiple sclerosis with combination of laquinimod and fingolimod
JP2016510343A (ja) * 2013-02-15 2016-04-07 テバ ファーマシューティカル インダストリーズ リミティド ラキニモドを用いる多発性硬化症の治療

Also Published As

Publication number Publication date
ZA201408820B (en) 2016-06-29
PE20150161A1 (es) 2015-02-22
JP2015515985A (ja) 2015-06-04
AR090885A1 (es) 2014-12-10
KR20150013658A (ko) 2015-02-05
US20150265592A1 (en) 2015-09-24
JP2017222691A (ja) 2017-12-21
EP2844255A4 (en) 2015-10-14
MX2014013039A (es) 2015-02-04
HK1206246A1 (en) 2016-01-08
SG11201406594UA (en) 2014-11-27
CL2014002935A1 (es) 2015-03-06
PH12014502447A1 (en) 2015-01-12
IL235337A0 (en) 2014-12-31
US20130303569A1 (en) 2013-11-14
EA201492010A1 (ru) 2015-06-30
EP2844255A1 (en) 2015-03-11
UY34775A (es) 2013-11-29
TW201347762A (zh) 2013-12-01
AU2013256352A1 (en) 2014-11-27
CA2870684A1 (en) 2013-11-07
BR112014027010A2 (pt) 2017-06-27
US20160000775A1 (en) 2016-01-07
WO2013166166A1 (en) 2013-11-07
CN104284663A (zh) 2015-01-14
CN105832733A (zh) 2016-08-10

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